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PRJEB1986: zebrafish developmental stages transcriptome

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Results for hic1

Z-value: 0.89

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Transcription factors associated with hic1

Gene Symbol Gene ID Gene Info
hic1
ENSDARG00000055493 hypermethylated in cancer 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hic1dr11_v1_chr15_+_25681044_256810440.709.0e-04Click!

Activity profile of hic1 motif

Sorted Z-values of hic1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_77557279 3.11 ENSDART00000180113
AL935186.10

chr4_-_77561679 2.90 ENSDART00000180809
AL935186.9

chr4_+_55778679 2.40 ENSDART00000183009
CT583728.19

chr4_+_55794876 2.40 ENSDART00000189043
CT583728.17

chr4_+_55810436 2.40 ENSDART00000182875
CT583728.16

chr4_-_68568233 2.40 ENSDART00000184284
BX548011.1

chr4_-_55728559 2.34 ENSDART00000186201
CT583728.14

chr1_+_9004719 1.52 ENSDART00000006211
ENSDART00000137211
prkcba
protein kinase C, beta a
chr19_-_22488952 1.30 ENSDART00000179856
ENSDART00000141503
pleca
plectin a
chr16_+_41067586 1.21 ENSDART00000181876
scap
SREBF chaperone
chr23_+_45611649 1.20 ENSDART00000169521
dclk2b
doublecortin-like kinase 2b
chr1_+_45839927 1.17 ENSDART00000148086
ENSDART00000180413
ENSDART00000048191
ENSDART00000179047
map2k7
mitogen-activated protein kinase kinase 7
chr10_-_2682198 1.16 ENSDART00000183727
pdxp
pyridoxal (pyridoxine, vitamin B6) phosphatase
chr15_-_18138607 1.09 ENSDART00000176690
CR385077.1

chr23_+_14590767 0.94 ENSDART00000143675
si:rp71-79p20.2
si:rp71-79p20.2
chr8_+_35172594 0.82 ENSDART00000177146
BX897670.1

chr4_+_90048 0.81 ENSDART00000166440
lrp6
low density lipoprotein receptor-related protein 6
chr4_-_68831753 0.77 ENSDART00000189170
si:dkey-264f17.1
si:dkey-264f17.1
chr13_-_37519774 0.76 ENSDART00000141420
ENSDART00000185478
sgpp1
sphingosine-1-phosphate phosphatase 1
chr19_-_3574060 0.71 ENSDART00000105120
tmem170b
transmembrane protein 170B
chr22_-_18116635 0.69 ENSDART00000005724
ncanb
neurocan b
chr4_-_797831 0.67 ENSDART00000158970
ENSDART00000170012
mapre3b
microtubule-associated protein, RP/EB family, member 3b
chr9_-_14992730 0.67 ENSDART00000137117
pard3bb
par-3 family cell polarity regulator beta b
chr14_-_48588422 0.66 ENSDART00000161147
si:ch211-154c21.1
si:ch211-154c21.1
chr9_-_849069 0.54 ENSDART00000136091
c1ql2
complement component 1, q subcomponent-like 2
chr15_-_9421481 0.53 ENSDART00000189045
ENSDART00000177158
sacs
sacsin molecular chaperone
chr19_-_12967986 0.51 ENSDART00000151064
slc25a32a
solute carrier family 25 (mitochondrial folate carrier), member 32a
chr6_-_1874664 0.48 ENSDART00000007972
dlgap4b
discs, large (Drosophila) homolog-associated protein 4b
chr11_-_6420917 0.46 ENSDART00000193717
FO681393.2

chr20_-_18915376 0.46 ENSDART00000063725
xkr6b
XK, Kell blood group complex subunit-related family, member 6b
chr17_-_8976307 0.42 ENSDART00000092113
zranb1b
zinc finger, RAN-binding domain containing 1b
chr19_-_19505167 0.39 ENSDART00000160582
creb5a
cAMP responsive element binding protein 5a
chr1_+_135903 0.37 ENSDART00000124837
f10
coagulation factor X
chr23_+_45611980 0.34 ENSDART00000181582
dclk2b
doublecortin-like kinase 2b
chr12_-_979789 0.33 ENSDART00000128188
daglb
diacylglycerol lipase, beta
chr3_-_56896702 0.32 ENSDART00000023265
ush1ga
Usher syndrome 1Ga (autosomal recessive)
chr17_-_49412313 0.29 ENSDART00000152100
mthfd1b
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b
chr1_-_8928841 0.27 ENSDART00000103652
grin2ab
glutamate receptor, ionotropic, N-methyl D-aspartate 2A, b
chr8_+_652840 0.25 ENSDART00000187470
LO018102.1

chr3_+_17653784 0.21 ENSDART00000159984
ENSDART00000157682
ENSDART00000187937
kat2a
K(lysine) acetyltransferase 2A
chr5_+_393738 0.21 ENSDART00000161456
june
JunE proto-oncogene, AP-1 transcription factor subunit
chr16_+_2565433 0.18 ENSDART00000188014
ENSDART00000171378
preb
prolactin regulatory element binding
chr8_-_13678415 0.16 ENSDART00000134153
ENSDART00000143331
si:dkey-258f14.3
si:dkey-258f14.3
chr19_-_38830582 0.16 ENSDART00000189966
ENSDART00000183055
adgrb2
adhesion G protein-coupled receptor B2
chr8_+_54137350 0.15 ENSDART00000164153
brpf1
bromodomain and PHD finger containing, 1
chr3_+_37083765 0.13 ENSDART00000125611
retreg3
reticulophagy regulator family member 3
chr2_+_21063660 0.11 ENSDART00000022765
riok1
RIO kinase 1 (yeast)
chr25_-_1687481 0.09 ENSDART00000163553
ENSDART00000179460
mon2
MON2 homolog, regulator of endosome-to-Golgi trafficking
chr3_-_61592417 0.05 ENSDART00000155082
nptx2a
neuronal pentraxin 2a
chr18_-_10298162 0.02 ENSDART00000007520
lrrc4.2
leucine rich repeat containing 4.2
chr19_+_17642356 0.01 ENSDART00000176431
CR382334.1

Network of associatons between targets according to the STRING database.

First level regulatory network of hic1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.2 GO:0006114 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
0.2 0.7 GO:0051660 establishment of centrosome localization(GO:0051660)
0.1 1.2 GO:0006991 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.1 0.4 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.1 0.3 GO:0098920 endocannabinoid signaling pathway(GO:0071926) retrograde trans-synaptic signaling by lipid(GO:0098920) retrograde trans-synaptic signaling by endocannabinoid(GO:0098921)
0.1 0.7 GO:0035372 protein localization to microtubule(GO:0035372) protein localization to microtubule plus-end(GO:1904825)
0.1 1.3 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 0.8 GO:0006670 sphingosine metabolic process(GO:0006670)
0.1 1.2 GO:0007257 activation of JUN kinase activity(GO:0007257) positive regulation of JUN kinase activity(GO:0043507)
0.0 0.2 GO:0090113 regulation of COPII vesicle coating(GO:0003400) regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis(GO:0090113)
0.0 0.5 GO:0070782 phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.0 0.3 GO:0050957 equilibrioception(GO:0050957)
0.0 0.8 GO:0044332 Wnt signaling pathway involved in dorsal/ventral axis specification(GO:0044332)
0.0 0.5 GO:0098962 regulation of postsynaptic neurotransmitter receptor activity(GO:0098962)
0.0 0.3 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.0 0.2 GO:1903010 regulation of bone development(GO:1903010)
0.0 0.3 GO:0060079 excitatory postsynaptic potential(GO:0060079)
0.0 0.1 GO:0061709 reticulophagy(GO:0061709)
0.0 0.1 GO:0044154 histone H3-K14 acetylation(GO:0044154)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 GO:0030056 hemidesmosome(GO:0030056)
0.0 1.2 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.7 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.2 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.5 GO:0098978 glutamatergic synapse(GO:0098978)
0.0 0.1 GO:0030688 preribosome, small subunit precursor(GO:0030688)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.2 0.8 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.2 0.5 GO:0008517 folic acid transporter activity(GO:0008517)
0.1 1.3 GO:0030506 ankyrin binding(GO:0030506)
0.1 1.5 GO:0004697 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.1 0.8 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.3 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.0 0.5 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 0.4 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.4 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.7 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 1.2 GO:0032934 sterol binding(GO:0032934)
0.0 0.3 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.1 GO:0043994 H3 histone acetyltransferase activity(GO:0010484) histone acetyltransferase activity (H3-K23 specific)(GO:0043994)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.1 1.2 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 0.8 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 0.8 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 0.4 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 0.3 PID NCADHERIN PATHWAY N-cadherin signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 0.4 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.8 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.2 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.3 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis