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PRJEB1986: zebrafish developmental stages transcriptome

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Results for hmx1+hmx3b

Z-value: 0.57

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Transcription factors associated with hmx1+hmx3b

Gene Symbol Gene ID Gene Info
hmx1
ENSDARG00000095651 H6 family homeobox 1
hmx3b
ENSDARG00000096716 H6 family homeobox 3b
hmx1
ENSDARG00000109725 H6 family homeobox 1
hmx1
ENSDARG00000111765 H6 family homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hmx3bdr11_v1_chr12_-_49154934_491549340.561.2e-02Click!
hmx1dr11_v1_chr1_-_40914752_40914752-0.311.9e-01Click!

Activity profile of hmx1+hmx3b motif

Sorted Z-values of hmx1+hmx3b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_30244356 2.85 ENSDART00000036050
ENSDART00000150080
rs1a
retinoschisin 1a
chr25_-_10503043 1.48 ENSDART00000155404
cox8b
cytochrome c oxidase subunit 8b
chr4_-_72609735 1.22 ENSDART00000174299
ENSDART00000159227
si:cabz01054394.6
si:cabz01054394.6
chr14_-_33454595 1.20 ENSDART00000109615
ENSDART00000173267
ENSDART00000185737
ENSDART00000190989
tmem255a
transmembrane protein 255A
chr7_+_66565930 1.19 ENSDART00000154597
tmem176l.3b
transmembrane protein 176l.3b
chr8_+_24861264 1.17 ENSDART00000099607
slc6a17
solute carrier family 6 (neutral amino acid transporter), member 17
chr1_-_22512063 1.15 ENSDART00000031546
ENSDART00000190987
chrna6
cholinergic receptor, nicotinic, alpha 6
chr21_+_21906671 1.15 ENSDART00000016916
gria4b
glutamate receptor, ionotropic, AMPA 4b
chr3_+_22327738 1.10 ENSDART00000055675
gh1
growth hormone 1
chr6_-_40697585 1.10 ENSDART00000113196
si:ch211-157b11.14
si:ch211-157b11.14
chr5_-_42272517 1.03 ENSDART00000137692
ENSDART00000164363
si:ch211-207c6.2
si:ch211-207c6.2
chr25_+_3326885 1.00 ENSDART00000104866
ldhbb
lactate dehydrogenase Bb
chr11_+_29770966 0.97 ENSDART00000088624
ENSDART00000124471
rpgrb
retinitis pigmentosa GTPase regulator b
chr12_+_24342303 0.97 ENSDART00000111239
nrxn1a
neurexin 1a
chr12_+_2446837 0.96 ENSDART00000112032
ARHGAP22
si:dkey-191m6.4
chr24_-_27400017 0.95 ENSDART00000145829
ccl34b.1
chemokine (C-C motif) ligand 34b, duplicate 1
chr2_-_16380283 0.81 ENSDART00000149992
si:dkey-231j24.3
si:dkey-231j24.3
chr9_-_36924388 0.81 ENSDART00000059756
ralba
v-ral simian leukemia viral oncogene homolog Ba (ras related)
chr20_-_34750045 0.76 ENSDART00000186130
znf395b
zinc finger protein 395b
chr7_+_32722227 0.73 ENSDART00000126565
si:ch211-150g13.3
si:ch211-150g13.3
chr21_-_14803366 0.73 ENSDART00000190872
si:dkey-11o18.5
si:dkey-11o18.5
chr11_-_37691449 0.71 ENSDART00000185340
zgc:158258
zgc:158258
chr8_-_19649617 0.64 ENSDART00000189033
fam78bb
family with sequence similarity 78, member B b
chr20_-_7128612 0.63 ENSDART00000146755
ENSDART00000036871
si:ch211-121a2.4
si:ch211-121a2.4
chr25_+_3327071 0.62 ENSDART00000136131
ENSDART00000133243
ldhbb
lactate dehydrogenase Bb
chr20_+_37295006 0.62 ENSDART00000153137
cx23
connexin 23
chr23_-_36857964 0.61 ENSDART00000188822
ENSDART00000134061
ENSDART00000093061
hipk1a
homeodomain interacting protein kinase 1a
chr10_-_33297864 0.59 ENSDART00000163360
PRDM15
PR/SET domain 15
chr10_-_39153959 0.58 ENSDART00000150193
ENSDART00000111362
slc37a4b
solute carrier family 37 (glucose-6-phosphate transporter), member 4b
chr20_+_28861629 0.58 ENSDART00000187274
ENSDART00000047826
slc10a1
solute carrier family 10 (sodium/bile acid cotransporter), member 1
chr19_+_9295244 0.57 ENSDART00000132255
ENSDART00000144299
si:ch73-15n24.1
si:ch73-15n24.1
chr22_+_724639 0.53 ENSDART00000105323
zgc:162255
zgc:162255
chr22_-_7129631 0.52 ENSDART00000171359
asic1b
acid-sensing (proton-gated) ion channel 1b
chr15_+_1134870 0.52 ENSDART00000155392
p2ry13
purinergic receptor P2Y13
chr1_+_34696503 0.49 ENSDART00000186106
CR339054.2

chr19_-_6239248 0.47 ENSDART00000014127
pou2f2a
POU class 2 homeobox 2a
chr4_-_837768 0.46 ENSDART00000185280
ENSDART00000135618
sobpb
sine oculis binding protein homolog (Drosophila) b
chr2_+_54798689 0.46 ENSDART00000183426
twsg1a
twisted gastrulation BMP signaling modulator 1a
chr21_-_14966718 0.44 ENSDART00000151200
mmp17a
matrix metallopeptidase 17a
chr10_-_39154594 0.44 ENSDART00000148825
slc37a4b
solute carrier family 37 (glucose-6-phosphate transporter), member 4b
chr1_+_52929185 0.44 ENSDART00000147683
inpp4b
inositol polyphosphate-4-phosphatase type II B
chr18_+_11970987 0.43 ENSDART00000144111
si:dkeyp-2c8.3
si:dkeyp-2c8.3
chr13_-_36911118 0.42 ENSDART00000048739
trim9
tripartite motif containing 9
chr8_-_46486009 0.39 ENSDART00000140431
sult1st9
sulfotransferase family 1, cytosolic sulfotransferase 9
chr13_+_23176330 0.39 ENSDART00000168351
sorbs1
sorbin and SH3 domain containing 1
chr5_+_24287927 0.36 ENSDART00000143563
zdhhc23a
zinc finger, DHHC-type containing 23a
chr22_-_6988102 0.35 ENSDART00000185618
fgfr1bl
fibroblast growth factor receptor 1b, like
chr4_-_4751981 0.33 ENSDART00000147436
ENSDART00000092984
ENSDART00000158466
creb3l2
cAMP responsive element binding protein 3-like 2
chr23_+_38953545 0.33 ENSDART00000184621
ATP9A
ATPase phospholipid transporting 9A (putative)
chr8_+_22472584 0.32 ENSDART00000138303
si:dkey-23c22.9
si:dkey-23c22.9
chr3_+_56366395 0.32 ENSDART00000154367
cacng5b
calcium channel, voltage-dependent, gamma subunit 5b
chr5_-_69620722 0.32 ENSDART00000097248
aldh2.2
aldehyde dehydrogenase 2 family (mitochondrial), tandem duplicate 2
chr20_-_5052786 0.32 ENSDART00000138818
ENSDART00000181655
ENSDART00000164274
arid1b
AT rich interactive domain 1B (SWI1-like)
chr18_-_5595546 0.31 ENSDART00000191825
cyp1a
cytochrome P450, family 1, subfamily A
chr13_-_4018888 0.31 ENSDART00000058238
tjap1
tight junction associated protein 1 (peripheral)
chr11_-_7261717 0.29 ENSDART00000128959
zgc:113223
zgc:113223
chr1_-_23596391 0.29 ENSDART00000155184
lcorl
ligand dependent nuclear receptor corepressor-like
chr20_+_28861435 0.27 ENSDART00000142678
slc10a1
solute carrier family 10 (sodium/bile acid cotransporter), member 1
chr5_+_19165949 0.25 ENSDART00000140710
unc13ba
unc-13 homolog Ba (C. elegans)
chr9_-_25425381 0.25 ENSDART00000129522
acvr2aa
activin A receptor type 2Aa
chr18_-_33080454 0.24 ENSDART00000191907
v2ra18
vomeronasal 2 receptor, a18
chr10_+_43039947 0.19 ENSDART00000193434
atg10
ATG10 autophagy related 10 homolog (S. cerevisiae)
chr6_+_4528631 0.19 ENSDART00000122042
RNF219
ring finger protein 219
chr21_+_21702623 0.19 ENSDART00000136840
or125-2
odorant receptor, family E, subfamily 125, member 2
chr5_+_11290851 0.18 ENSDART00000180408
CABZ01077124.1

chr8_+_7097740 0.18 ENSDART00000159670
abtb1
ankyrin repeat and BTB (POZ) domain containing 1
chr15_-_1822548 0.17 ENSDART00000082026
ENSDART00000180230
mmp28
matrix metallopeptidase 28
chr5_-_25645593 0.17 ENSDART00000044471
tmc2b
transmembrane channel-like 2b
chrM_+_8130 0.16 ENSDART00000093609
mt-co2
cytochrome c oxidase II, mitochondrial
chr19_+_11217279 0.16 ENSDART00000181859
si:ch73-109i22.2
si:ch73-109i22.2
chr24_+_26134209 0.13 ENSDART00000038824
tmtopsb
teleost multiple tissue opsin b
chr22_+_14117078 0.13 ENSDART00000013575
bzw1a
basic leucine zipper and W2 domains 1a
chr5_+_37032038 0.13 ENSDART00000045036
nfkbib
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr6_+_11681011 0.13 ENSDART00000151447
ENSDART00000151618
calcrlb
calcitonin receptor-like b
chr19_+_43604256 0.11 ENSDART00000151080
ENSDART00000110305
si:ch211-199g17.9
si:ch211-199g17.9
chr17_+_50076501 0.10 ENSDART00000156303
vps39
vacuolar protein sorting 39 homolog (S. cerevisiae)
chr22_-_4649238 0.10 ENSDART00000125302
fbn2b
fibrillin 2b
chr16_-_15988320 0.08 ENSDART00000160883
CABZ01060453.1

chr5_+_32009542 0.07 ENSDART00000182025
ENSDART00000179879
scai
suppressor of cancer cell invasion
chr22_-_20695237 0.07 ENSDART00000112722
org
oogenesis-related gene
chr16_-_35427060 0.07 ENSDART00000172294
ctps1b
CTP synthase 1b
chr13_+_30169681 0.07 ENSDART00000138326
pald1b
phosphatase domain containing, paladin 1b
chr7_-_56766973 0.06 ENSDART00000020967
csnk2a2a
casein kinase 2, alpha prime polypeptide a
chr13_-_37109987 0.05 ENSDART00000136750
syne2b
spectrin repeat containing, nuclear envelope 2b
chrM_+_4993 0.04 ENSDART00000093600
mt-nd2
NADH dehydrogenase 2, mitochondrial
chr17_+_6563307 0.04 ENSDART00000156454
adgrf3a
adhesion G protein-coupled receptor F3a
chr14_-_9128919 0.04 ENSDART00000108641
sh2d1ab
SH2 domain containing 1A duplicate b
chr6_+_40951227 0.03 ENSDART00000156660
patz1
POZ (BTB) and AT hook containing zinc finger 1

Network of associatons between targets according to the STRING database.

First level regulatory network of hmx1+hmx3b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0015824 proline transport(GO:0015824)
0.2 1.1 GO:0050996 positive regulation of lipid catabolic process(GO:0050996)
0.1 0.3 GO:0070278 extracellular matrix constituent secretion(GO:0070278)
0.1 1.0 GO:0046548 retinal rod cell development(GO:0046548)
0.1 0.5 GO:0070207 protein homotrimerization(GO:0070207)
0.1 0.5 GO:0031063 regulation of histone deacetylation(GO:0031063)
0.1 0.8 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.1 1.1 GO:0014823 response to activity(GO:0014823)
0.0 0.2 GO:0099525 synaptic vesicle docking(GO:0016081) presynaptic dense core granule exocytosis(GO:0099525)
0.0 0.1 GO:0060958 cell proliferation involved in heart valve morphogenesis(GO:0003249) regulation of cell proliferation involved in heart valve morphogenesis(GO:0003250) endocardial cell development(GO:0060958) cell proliferation involved in heart valve development(GO:2000793)
0.0 0.6 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0 1.7 GO:0006119 oxidative phosphorylation(GO:0006119)
0.0 0.9 GO:0002548 monocyte chemotaxis(GO:0002548)
0.0 0.6 GO:0044243 collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243)
0.0 0.3 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.0 0.2 GO:0060004 reflex(GO:0060004) vestibular reflex(GO:0060005)
0.0 0.1 GO:0044210 'de novo' CTP biosynthetic process(GO:0044210)
0.0 0.4 GO:0051923 sulfation(GO:0051923)
0.0 0.1 GO:0034058 endosomal vesicle fusion(GO:0034058)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 0.3 GO:0035060 brahma complex(GO:0035060)
0.0 1.5 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.2 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.1 GO:0097268 cytoophidium(GO:0097268)
0.0 0.6 GO:0016605 PML body(GO:0016605)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0070186 growth hormone receptor binding(GO:0005131) growth hormone activity(GO:0070186)
0.2 1.6 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 0.8 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.1 0.5 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.1 1.1 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 0.2 GO:0019777 Atg12 transferase activity(GO:0019777)
0.1 0.4 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316)
0.1 1.6 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.3 GO:0070330 aromatase activity(GO:0070330)
0.0 1.1 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.4 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.0 0.1 GO:0001635 adrenomedullin receptor activity(GO:0001605) calcitonin gene-related peptide receptor activity(GO:0001635)
0.0 0.2 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.5 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.3 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.0 0.3 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.1 GO:0003883 CTP synthase activity(GO:0003883)
0.0 0.2 GO:0017002 activin-activated receptor activity(GO:0017002)
0.0 0.5 GO:0019003 GDP binding(GO:0019003)
0.0 2.2 GO:0015293 symporter activity(GO:0015293)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID HNF3A PATHWAY FOXA1 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.1 1.1 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 1.1 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.5 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.4 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.4 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane