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PRJEB1986: zebrafish developmental stages transcriptome

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Results for hoxb13a

Z-value: 0.62

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Transcription factors associated with hoxb13a

Gene Symbol Gene ID Gene Info
hoxb13a
ENSDARG00000056015 homeobox B13a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hoxb13adr11_v1_chr3_+_23654233_236542330.502.7e-02Click!

Activity profile of hoxb13a motif

Sorted Z-values of hoxb13a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_15382704 2.19 ENSDART00000005313
zgc:85722
zgc:85722
chr12_+_41697664 1.92 ENSDART00000162302
bnip3
BCL2 interacting protein 3
chr4_-_4387012 1.39 ENSDART00000191836
CU468826.3
Danio rerio U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1-like (LOC100331497), mRNA.
chr10_-_14929392 1.32 ENSDART00000137430
smad2
SMAD family member 2
chr9_-_14683574 1.31 ENSDART00000144022
pard3bb
par-3 family cell polarity regulator beta b
chr20_-_27733683 1.31 ENSDART00000103317
ENSDART00000138139
zgc:153157
zgc:153157
chr20_-_25709247 1.29 ENSDART00000146711
si:dkeyp-117h8.2
si:dkeyp-117h8.2
chr1_+_52481332 1.25 ENSDART00000074231
cldnd1b
claudin domain containing 1b
chr2_+_45548890 1.22 ENSDART00000113994
fndc7a
fibronectin type III domain containing 7a
chr8_+_25351863 1.17 ENSDART00000034092
dnase1l1l
deoxyribonuclease I-like 1-like
chr5_-_46980651 1.13 ENSDART00000181022
ENSDART00000168038
edil3a
EGF-like repeats and discoidin I-like domains 3a
chr12_-_31457301 1.11 ENSDART00000043887
ENSDART00000148603
acsl5
acyl-CoA synthetase long chain family member 5
chr24_-_23675446 1.09 ENSDART00000066644
hnf4g
hepatocyte nuclear factor 4, gamma
chr10_-_22249444 1.06 ENSDART00000148831
fgf11b
fibroblast growth factor 11b
chr19_-_5380770 1.06 ENSDART00000000221
krt91
keratin 91
chr1_-_9249943 1.05 ENSDART00000055011
zgc:136472
zgc:136472
chr25_-_35599887 1.04 ENSDART00000153827
clpxb
caseinolytic mitochondrial matrix peptidase chaperone subunit b
chr10_+_39164638 1.00 ENSDART00000188997
CU633908.1

chr12_+_27704015 0.99 ENSDART00000153256
cacna1g
calcium channel, voltage-dependent, T type, alpha 1G subunit
chr15_+_45586471 0.98 ENSDART00000165699
cldn15lb
claudin 15-like b
chr19_-_6193448 0.97 ENSDART00000151405
erf
Ets2 repressor factor
chr25_-_31739309 0.93 ENSDART00000098896
acot19
acyl-CoA thioesterase 19
chr16_+_21738194 0.82 ENSDART00000163688
FP085428.1
Danio rerio si:ch211-154o6.4 (si:ch211-154o6.4), mRNA.
chr20_+_40150612 0.81 ENSDART00000143680
ENSDART00000109681
ENSDART00000101041
ENSDART00000121818
trdn
triadin
chr24_-_20808283 0.80 ENSDART00000143759
vipr1b
vasoactive intestinal peptide receptor 1b
chr25_+_19106574 0.77 ENSDART00000067332
rlbp1b
retinaldehyde binding protein 1b
chr19_-_40776267 0.75 ENSDART00000189038
calcr
calcitonin receptor
chr23_+_35759843 0.69 ENSDART00000047082
gdap1l1
ganglioside induced differentiation associated protein 1-like 1
chr18_+_39327010 0.67 ENSDART00000012164
tmod2
tropomodulin 2
chr15_-_28596507 0.67 ENSDART00000156800
si:ch211-225b7.5
si:ch211-225b7.5
chr20_-_52338782 0.66 ENSDART00000109735
ENSDART00000132941
si:ch1073-287p18.1
si:ch1073-287p18.1
chr17_-_7371564 0.66 ENSDART00000060336
rab32b
RAB32b, member RAS oncogene family
chr11_+_45110865 0.65 ENSDART00000158188
mgea5l
meningioma expressed antigen 5 (hyaluronidase) like
chr18_-_9046805 0.65 ENSDART00000134224
grm3
glutamate receptor, metabotropic 3
chr1_-_1627487 0.63 ENSDART00000166094
clic6
chloride intracellular channel 6
chr25_-_31898552 0.63 ENSDART00000156128
si:ch73-330k17.3
si:ch73-330k17.3
chr13_+_1182257 0.63 ENSDART00000033528
ENSDART00000183702
ENSDART00000147959
tnfaip3
tumor necrosis factor, alpha-induced protein 3
chr5_-_26181863 0.62 ENSDART00000098500
ccdc125
coiled-coil domain containing 125
chr2_-_31661609 0.61 ENSDART00000144383
si:ch211-106h4.9
si:ch211-106h4.9
chr17_-_52587598 0.59 ENSDART00000061497
si:ch211-173a9.6
si:ch211-173a9.6
chr18_+_1154189 0.59 ENSDART00000135090
si:ch1073-75f15.2
si:ch1073-75f15.2
chr8_-_25120231 0.58 ENSDART00000147308
amigo1
adhesion molecule with Ig-like domain 1
chr6_+_49723289 0.54 ENSDART00000190452
stx16
syntaxin 16
chr20_+_29743904 0.53 ENSDART00000146366
ENSDART00000153154
kidins220b
kinase D-interacting substrate 220b
chr3_+_46271911 0.49 ENSDART00000186557
ENSDART00000113531
mkl2b
MKL/myocardin-like 2b
chr11_-_29623380 0.48 ENSDART00000162587
ENSDART00000193935
ENSDART00000191646
chd5
chromodomain helicase DNA binding protein 5
chr6_+_45300746 0.48 ENSDART00000159176
BX942846.1

chr12_-_3705862 0.48 ENSDART00000193864
ENSDART00000185857
CABZ01069040.1

chr8_+_10339869 0.47 ENSDART00000132253
tbc1d22b
TBC1 domain family, member 22B
chr22_-_13466246 0.45 ENSDART00000134035
cntnap5b
contactin associated protein-like 5b
chr23_+_13124085 0.44 ENSDART00000139475
samd10b
sterile alpha motif domain containing 10b
chr23_-_7799184 0.43 ENSDART00000190946
ENSDART00000165427
myt1b
myelin transcription factor 1b
chr24_-_36238054 0.41 ENSDART00000155725
tmem241
transmembrane protein 241
chr7_-_31781339 0.40 ENSDART00000142666
nap1l4b
nucleosome assembly protein 1-like 4b
chr20_+_34717403 0.39 ENSDART00000034252
pnocb
prepronociceptin b
chr2_+_11029138 0.38 ENSDART00000138737
ENSDART00000081058
ENSDART00000153662
acot11a
acyl-CoA thioesterase 11a
chr5_-_67750907 0.37 ENSDART00000172097
b4galt4
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4
chr5_+_22510639 0.36 ENSDART00000080919
rpl36a
ribosomal protein L36A
chr16_-_27628994 0.36 ENSDART00000157407
nacad
NAC alpha domain containing
chr2_+_16597011 0.35 ENSDART00000160641
ENSDART00000125413
xrn1
5'-3' exoribonuclease 1
chr1_+_2321384 0.34 ENSDART00000157662
farp1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr25_+_4750972 0.32 ENSDART00000168903
si:zfos-2372e4.1
si:zfos-2372e4.1
chr1_-_44940830 0.31 ENSDART00000097500
ENSDART00000134464
ENSDART00000137216
tmem176
transmembrane protein 176
chr12_-_34758474 0.30 ENSDART00000153418
bahcc1b
BAH domain and coiled-coil containing 1b
chr22_+_2390544 0.30 ENSDART00000147345
ENSDART00000133611
zgc:171435
zgc:171435
chr8_+_30709685 0.30 ENSDART00000133989
upb1
ureidopropionase, beta
chr2_-_4070850 0.29 ENSDART00000159990
yme1l1b
YME1-like 1b
chr2_-_31735142 0.29 ENSDART00000130903
ralyl
RALY RNA binding protein like
chr21_-_37733287 0.29 ENSDART00000157826
mpp1
membrane protein, palmitoylated 1
chr1_-_58562129 0.28 ENSDART00000159070
slc27a1b
solute carrier family 27 (fatty acid transporter), member 1b
chr7_-_8324927 0.27 ENSDART00000102535
f13a1b
coagulation factor XIII, A1 polypeptide b
chr23_+_30048849 0.26 ENSDART00000126027
uts2a
urotensin 2, alpha
chr10_+_32066355 0.26 ENSDART00000062311
si:dkey-250d21.1
si:dkey-250d21.1
chr16_+_39485608 0.25 ENSDART00000188085
CR855318.1

chr10_+_32066537 0.21 ENSDART00000124166
si:dkey-250d21.1
si:dkey-250d21.1
chr7_+_27251376 0.18 ENSDART00000173521
ENSDART00000173962
sox6
SRY (sex determining region Y)-box 6
chr11_-_30611814 0.16 ENSDART00000089803
slc8a1a
solute carrier family 8 (sodium/calcium exchanger), member 1a
chr24_+_1042594 0.16 ENSDART00000109117
si:dkey-192l18.9
si:dkey-192l18.9
chr15_+_11381532 0.16 ENSDART00000124172
si:ch73-321d9.2
si:ch73-321d9.2
chr8_+_25352268 0.13 ENSDART00000187829
dnase1l1l
deoxyribonuclease I-like 1-like
chr17_+_31820401 0.11 ENSDART00000192607
ENSDART00000157490
eef1akmt2
EEF1A lysine methyltransferase 2
chr1_-_58561963 0.11 ENSDART00000165040
slc27a1b
solute carrier family 27 (fatty acid transporter), member 1b
chr13_+_17694845 0.11 ENSDART00000079778
ifit8
interferon-induced protein with tetratricopeptide repeats 8
chr6_-_28222592 0.11 ENSDART00000131126
bcl6a
B-cell CLL/lymphoma 6a (zinc finger protein 51)
chr4_-_49987980 0.10 ENSDART00000150428
si:dkey-156k2.4
si:dkey-156k2.4
chr9_+_24125445 0.07 ENSDART00000090346
pgap1
post-GPI attachment to proteins 1
chr22_+_11857356 0.07 ENSDART00000179540
mras
muscle RAS oncogene homolog
chr1_+_47486104 0.06 ENSDART00000114746
lrrc58a
leucine rich repeat containing 58a
chr11_+_18873619 0.06 ENSDART00000176141
magi1b
membrane associated guanylate kinase, WW and PDZ domain containing 1b
chr1_+_44941031 0.05 ENSDART00000141145
si:dkey-9i23.16
si:dkey-9i23.16
chr22_+_18187857 0.03 ENSDART00000166300
mef2b
myocyte enhancer factor 2b
chr19_-_17526735 0.03 ENSDART00000189391
thrb
thyroid hormone receptor beta
chr7_-_26497947 0.02 ENSDART00000058910
sox19b
SRY (sex determining region Y)-box 19b
chr12_-_16524727 0.01 ENSDART00000166645
FO704724.1

chr10_-_14929630 0.01 ENSDART00000121892
ENSDART00000044756
ENSDART00000128579
ENSDART00000147653
smad2
SMAD family member 2

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxb13a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:1902001 regulation of plasma membrane long-chain fatty acid transport(GO:0010746) positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747) plasma membrane long-chain fatty acid transport(GO:0015911) fatty acid transmembrane transport(GO:1902001) positive regulation of anion transmembrane transport(GO:1903961) regulation of fatty acid transport(GO:2000191) positive regulation of fatty acid transport(GO:2000193)
0.3 1.3 GO:0051660 establishment of centrosome localization(GO:0051660)
0.2 1.3 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.2 1.9 GO:0097345 mitochondrial outer membrane permeabilization(GO:0097345)
0.1 0.6 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.1 0.4 GO:0003322 pancreatic A cell development(GO:0003322)
0.1 0.4 GO:0031650 heat generation(GO:0031649) regulation of heat generation(GO:0031650) positive regulation of heat generation(GO:0031652) regulation of phospholipid biosynthetic process(GO:0071071) negative regulation of phospholipid biosynthetic process(GO:0071072)
0.1 1.3 GO:0000737 DNA catabolic process, endonucleolytic(GO:0000737)
0.1 1.1 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.1 0.7 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.1 0.3 GO:0019482 beta-alanine metabolic process(GO:0019482) beta-alanine biosynthetic process(GO:0019483)
0.1 1.0 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.0 0.6 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.0 1.0 GO:0035622 intrahepatic bile duct development(GO:0035622)
0.0 0.7 GO:0032438 melanosome organization(GO:0032438)
0.0 0.8 GO:0007634 optokinetic behavior(GO:0007634)
0.0 0.6 GO:0007413 axonal fasciculation(GO:0007413)
0.0 0.4 GO:0016075 rRNA catabolic process(GO:0016075)
0.0 0.6 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0 0.2 GO:0060612 adipose tissue development(GO:0060612)
0.0 0.3 GO:0072378 blood coagulation, fibrin clot formation(GO:0072378)
0.0 0.1 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.0 1.3 GO:0006637 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.0 0.3 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 0.4 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.0 1.0 GO:0001518 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.8 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.7 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 2.3 GO:0043296 apical junction complex(GO:0043296)
0.0 0.6 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 1.6 GO:0005741 mitochondrial outer membrane(GO:0005741)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0097643 amylin receptor activity(GO:0097643)
0.1 1.0 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.1 0.8 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.1 1.3 GO:0004530 deoxyribonuclease I activity(GO:0004530)
0.1 1.0 GO:0001217 bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding(GO:0001130) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217)
0.1 1.1 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.1 0.6 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
0.1 0.4 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.1 1.3 GO:0070411 I-SMAD binding(GO:0070411)
0.1 0.4 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 1.3 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.0 1.2 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.6 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 1.1 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.3 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.0 0.7 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.4 GO:0031628 opioid receptor binding(GO:0031628)
0.0 1.1 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 0.6 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 1.1 GO:0005178 integrin binding(GO:0005178)
0.0 0.5 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.4 GO:0008378 galactosyltransferase activity(GO:0008378)
0.0 0.3 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.6 GO:0017022 myosin binding(GO:0017022)
0.0 0.2 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 1.1 GO:0051082 unfolded protein binding(GO:0051082)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.9 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.6 PID CD40 PATHWAY CD40/CD40L signaling
0.0 1.0 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 1.3 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.1 0.6 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 1.1 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.3 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.5 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.4 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0 1.0 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.6 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.4 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation