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PRJEB1986: zebrafish developmental stages transcriptome

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Results for hoxb8a+hoxb8b

Z-value: 0.63

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Transcription factors associated with hoxb8a+hoxb8b

Gene Symbol Gene ID Gene Info
hoxb8b
ENSDARG00000054025 homeobox B8b
hoxb8a
ENSDARG00000056027 homeobox B8a
hoxb8b
ENSDARG00000111056 homeobox B8b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hoxb8bdr11_v1_chr12_+_27117609_27117609-0.446.2e-02Click!
hoxb8adr11_v1_chr3_+_23687909_23687909-0.381.0e-01Click!

Activity profile of hoxb8a+hoxb8b motif

Sorted Z-values of hoxb8a+hoxb8b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_17676745 2.24 ENSDART00000030665
slc25a4
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
chr4_-_4387012 1.95 ENSDART00000191836
CU468826.3
Danio rerio U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1-like (LOC100331497), mRNA.
chr9_+_42066030 1.83 ENSDART00000185311
ENSDART00000015267
pcbp3
poly(rC) binding protein 3
chr18_-_38088099 1.70 ENSDART00000146120
luzp2
leucine zipper protein 2
chr22_+_18389271 1.68 ENSDART00000088270
yjefn3
YjeF N-terminal domain containing 3
chr12_+_39685485 1.67 ENSDART00000163403
LO017650.1

chr19_-_3123963 1.55 ENSDART00000122816
si:ch211-80h18.1
si:ch211-80h18.1
chr20_-_29420713 1.54 ENSDART00000147464
ryr3
ryanodine receptor 3
chr18_+_783936 1.54 ENSDART00000193357
rpp25b
ribonuclease P and MRP subunit p25, b
chr18_+_13792490 1.47 ENSDART00000136754
cdh13
cadherin 13, H-cadherin (heart)
chr2_+_2223837 1.43 ENSDART00000101038
ENSDART00000129354
tmie
transmembrane inner ear
chr3_+_26813058 1.26 ENSDART00000055537
socs1a
suppressor of cytokine signaling 1a
chr8_-_34051548 1.22 ENSDART00000105204
pbx3b
pre-B-cell leukemia homeobox 3b
chr24_-_40009446 1.21 ENSDART00000087422
aoc1
amine oxidase, copper containing 1
chr8_-_34052019 1.21 ENSDART00000040126
ENSDART00000159208
ENSDART00000048994
ENSDART00000098822
pbx3b
pre-B-cell leukemia homeobox 3b
chr12_-_26406323 1.21 ENSDART00000131896
myoz1b
myozenin 1b
chr2_-_9646857 1.21 ENSDART00000056901
zgc:153615
zgc:153615
chr18_+_21408794 1.19 ENSDART00000140161
necab2
N-terminal EF-hand calcium binding protein 2
chr6_-_43449013 1.19 ENSDART00000122423
eevs
2-epi-5-epi-valiolone synthase
chr8_-_52413032 1.17 ENSDART00000183039
CABZ01070469.1

chr12_-_11457625 1.17 ENSDART00000012318
htra1b
HtrA serine peptidase 1b
chr17_+_39242437 1.11 ENSDART00000156138
ENSDART00000128863
zgc:174356
zgc:174356
chr10_-_39011514 1.08 ENSDART00000075123
pcp4a
Purkinje cell protein 4a
chr2_+_7818368 1.06 ENSDART00000007068
kcnmb2
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr16_+_10776688 1.06 ENSDART00000161969
ENSDART00000172657
atp1a3b
ATPase Na+/K+ transporting subunit alpha 3b
chr9_-_23217196 1.06 ENSDART00000083567
kif5c
kinesin family member 5C
chr2_+_31665836 1.06 ENSDART00000135411
ENSDART00000143914
si:ch211-106h4.12
si:ch211-106h4.12
chr11_-_44030962 1.05 ENSDART00000171910
FP016005.1

chr16_+_17389116 1.03 ENSDART00000103750
ENSDART00000173448
fam131bb
family with sequence similarity 131, member Bb
chr15_+_4632782 1.03 ENSDART00000156012
si:dkey-35i13.1
si:dkey-35i13.1
chr11_+_24002503 1.01 ENSDART00000164702
chia.2
chitinase, acidic.2
chr1_-_19215336 0.98 ENSDART00000162949
ENSDART00000170680
ptprdb
protein tyrosine phosphatase, receptor type, D, b
chr13_-_30027730 0.92 ENSDART00000044009
scdb
stearoyl-CoA desaturase b
chr11_+_36243774 0.88 ENSDART00000023323
zgc:172270
zgc:172270
chr19_+_37925616 0.87 ENSDART00000148348
nxph1
neurexophilin 1
chr3_-_34337969 0.86 ENSDART00000151634
tnrc6c1
trinucleotide repeat containing 6C1
chr7_+_31879986 0.81 ENSDART00000138491
mybpc3
myosin binding protein C, cardiac
chr24_+_25259154 0.81 ENSDART00000171125
gabrr3b
gamma-aminobutyric acid (GABA) A receptor, rho 3b
chr12_-_3756405 0.80 ENSDART00000150839
fam57bb
family with sequence similarity 57, member Bb
chr20_+_20672163 0.80 ENSDART00000027758
rtn1b
reticulon 1b
chr7_+_13382852 0.80 ENSDART00000166318
dagla
diacylglycerol lipase, alpha
chr18_+_10840071 0.79 ENSDART00000014496
mical3a
microtubule associated monooxygenase, calponin and LIM domain containing 3a
chr4_+_12292274 0.78 ENSDART00000061070
ENSDART00000150786
mkrn1
makorin, ring finger protein, 1
chr6_-_28980756 0.78 ENSDART00000014661
glmnb
glomulin, FKBP associated protein b
chr21_+_40092301 0.75 ENSDART00000145150
serpinf2a
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2a
chr11_-_3959889 0.70 ENSDART00000159683
pbrm1
polybromo 1
chr24_-_6898302 0.69 ENSDART00000158646
dpp6a
dipeptidyl-peptidase 6a
chr5_+_9382301 0.68 ENSDART00000124017
ugt2a7
UDP glucuronosyltransferase 2 family, polypeptide A7
chr18_+_27218737 0.68 ENSDART00000111450
plekha7a
pleckstrin homology domain containing, family A member 7a
chr1_-_21901589 0.67 ENSDART00000140553
frmpd1a
FERM and PDZ domain containing 1a
chr10_+_26571174 0.66 ENSDART00000148617
ENSDART00000112956
slc9a6b
solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6b
chr7_+_31879649 0.66 ENSDART00000099789
mybpc3
myosin binding protein C, cardiac
chr4_+_7391110 0.65 ENSDART00000160708
ENSDART00000187823
tnni4a
troponin I4a
chr7_-_35126374 0.64 ENSDART00000141211
hsd11b2
hydroxysteroid (11-beta) dehydrogenase 2
chr1_-_23157583 0.64 ENSDART00000144208
adgrl3.1
adhesion G protein-coupled receptor L3.1
chr2_+_33368414 0.64 ENSDART00000077462
slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr17_-_30666037 0.64 ENSDART00000156509
alkal2b
ALK and LTK ligand 2b
chr20_-_8443425 0.63 ENSDART00000083908
dab1a
Dab, reelin signal transducer, homolog 1a (Drosophila)
chr20_-_40754794 0.61 ENSDART00000187251
cx32.3
connexin 32.3
chr13_-_8776474 0.60 ENSDART00000122371
STPG4
si:ch211-93n23.7
chr24_+_24461341 0.58 ENSDART00000147658
bhlhe22
basic helix-loop-helix family, member e22
chr20_+_1088658 0.57 ENSDART00000162991
BX537249.1

chr2_-_54039293 0.56 ENSDART00000166013
abhd8a
abhydrolase domain containing 8a
chr24_+_5840258 0.56 ENSDART00000087034
trpc1
transient receptor potential cation channel, subfamily C, member 1
chr5_+_9377005 0.55 ENSDART00000124924
ugt2a7
UDP glucuronosyltransferase 2 family, polypeptide A7
chr14_+_35237613 0.55 ENSDART00000163465
ebf3a
early B cell factor 3a
chr23_-_11870962 0.54 ENSDART00000143481
si:dkey-178k16.1
si:dkey-178k16.1
chr11_-_3959477 0.53 ENSDART00000045971
pbrm1
polybromo 1
chr24_+_24461558 0.52 ENSDART00000182424
bhlhe22
basic helix-loop-helix family, member e22
chr20_-_19590378 0.51 ENSDART00000152588
baalcb
brain and acute leukemia, cytoplasmic b
chr17_-_26507289 0.49 ENSDART00000155616
ccser2a
coiled-coil serine-rich protein 2a
chr11_+_6819050 0.48 ENSDART00000104289
rab3ab
RAB3A, member RAS oncogene family, b
chr5_+_9405283 0.47 ENSDART00000127306
ugt2a7
UDP glucuronosyltransferase 2 family, polypeptide A7
chr14_+_25465346 0.46 ENSDART00000173436
si:dkey-280e21.3
si:dkey-280e21.3
chr5_-_34185115 0.46 ENSDART00000192771
fibcd1
fibrinogen C domain containing 1
chr9_-_39547907 0.45 ENSDART00000163635
erbb4b
erb-b2 receptor tyrosine kinase 4b
chr23_+_28322986 0.45 ENSDART00000134710
birc5b
baculoviral IAP repeat containing 5b
chr6_+_37894914 0.45 ENSDART00000148817
oca2
oculocutaneous albinism II
chr14_+_36231126 0.44 ENSDART00000141766
elovl6
ELOVL fatty acid elongase 6
chr19_+_12444943 0.44 ENSDART00000135706
ldlrad4a
low density lipoprotein receptor class A domain containing 4a
chr12_+_18458502 0.44 ENSDART00000108745
rnf151
ring finger protein 151
chr4_+_13810811 0.44 ENSDART00000067168
pdzrn4
PDZ domain containing ring finger 4
chr2_+_35240764 0.42 ENSDART00000015827
tnr
tenascin R (restrictin, janusin)
chr23_-_30960506 0.41 ENSDART00000142661
osbpl2a
oxysterol binding protein-like 2a
chr8_-_14484599 0.40 ENSDART00000057644
lhx4
LIM homeobox 4
chr19_+_5480327 0.39 ENSDART00000148794
jupb
junction plakoglobin b
chr6_+_23931236 0.37 ENSDART00000166079
gadd45ab
growth arrest and DNA-damage-inducible, alpha, b
chr21_-_22812417 0.37 ENSDART00000079151
ENSDART00000112175
trpc6a
transient receptor potential cation channel, subfamily C, member 6a
chr15_-_5467477 0.36 ENSDART00000123839
arrb1
arrestin, beta 1
chr2_+_38608290 0.36 ENSDART00000159066
cdh24b
cadherin 24, type 2b
chr3_-_16227683 0.34 ENSDART00000111707
cacnb1
calcium channel, voltage-dependent, beta 1 subunit
chr2_-_24603325 0.34 ENSDART00000113356
crtc1a
CREB regulated transcription coactivator 1a
chr10_-_7785930 0.34 ENSDART00000043961
ENSDART00000111058
mpx
myeloid-specific peroxidase
chr21_-_22547496 0.33 ENSDART00000166835
ENSDART00000089030
myo5b
myosin VB
chr2_+_37480669 0.33 ENSDART00000029801
sppl2
signal peptide peptidase-like 2
chr20_-_2949028 0.32 ENSDART00000104667
ENSDART00000193151
ENSDART00000131946
cdk19
cyclin-dependent kinase 19
chr13_+_36622100 0.32 ENSDART00000133198
si:ch211-67f24.7
si:ch211-67f24.7
chr20_+_32152355 0.32 ENSDART00000152904
ENSDART00000139507
sesn1
sestrin 1
chr25_-_31702970 0.31 ENSDART00000153586
lamb4
laminin, beta 4
chr17_+_19626479 0.31 ENSDART00000044993
ENSDART00000131863
rgs7a
regulator of G protein signaling 7a
chr13_+_23282549 0.31 ENSDART00000101134
khdrbs2
KH domain containing, RNA binding, signal transduction associated 2
chr5_-_825920 0.31 ENSDART00000126982
zgc:158463
zgc:158463
chr21_-_27338639 0.28 ENSDART00000130632
hif1al2
hypoxia-inducible factor 1, alpha subunit, like 2
chr18_+_34225520 0.28 ENSDART00000126115
v2rl1
vomeronasal 2 receptor, l1
chr3_-_34717882 0.27 ENSDART00000151127
thraa
thyroid hormone receptor alpha a
chr17_-_38778826 0.27 ENSDART00000168182
ENSDART00000124041
ENSDART00000136921
dglucy
D-glutamate cyclase
chr6_+_45347219 0.26 ENSDART00000188240
LO017951.1

chr3_-_16227490 0.26 ENSDART00000057159
ENSDART00000130611
ENSDART00000012835
cacnb1
calcium channel, voltage-dependent, beta 1 subunit
chr18_+_50890749 0.26 ENSDART00000174109
si:ch1073-450f2.1
si:ch1073-450f2.1
chr7_-_31938938 0.26 ENSDART00000132353
bdnf
brain-derived neurotrophic factor
chr3_+_52753416 0.26 ENSDART00000171185
gmip
GEM interacting protein
chr23_+_5490854 0.26 ENSDART00000175403
tulp1a
tubby like protein 1a
chr2_-_10188598 0.25 ENSDART00000189122
dmbx1a
diencephalon/mesencephalon homeobox 1a
chr14_-_6666854 0.25 ENSDART00000133031
si:dkeyp-44a8.4
si:dkeyp-44a8.4
chr12_+_22404108 0.25 ENSDART00000153055
hdlbpb
high density lipoprotein binding protein b
chr21_-_26918901 0.25 ENSDART00000100685
lrfn4a
leucine rich repeat and fibronectin type III domain containing 4a
chr11_-_2838699 0.24 ENSDART00000066189
lhfpl5a
LHFPL tetraspan subfamily member 5a
chr3_-_33574576 0.24 ENSDART00000184881
CR847537.1

chr19_+_43341424 0.23 ENSDART00000134815
sesn2
sestrin 2
chr25_-_12809361 0.23 ENSDART00000162750
ca5a
carbonic anhydrase Va
chr6_+_52804267 0.23 ENSDART00000065681
matn4
matrilin 4
chr1_-_43862638 0.23 ENSDART00000145044
tacr3a
tachykinin receptor 3a
chr5_-_32813933 0.22 ENSDART00000050041
ENSDART00000135864
ptpa
protein phosphatase 2 phosphatase activator
chr6_-_43677125 0.22 ENSDART00000150128
foxp1b
forkhead box P1b
chr10_-_33156789 0.21 ENSDART00000192268
ENSDART00000182065
ENSDART00000081170
cux1a
cut-like homeobox 1a
chr5_+_19094153 0.21 ENSDART00000186525
ENSDART00000064752
unc13ba
unc-13 homolog Ba (C. elegans)
chr16_-_31451720 0.20 ENSDART00000146886
csnk2a1
casein kinase 2, alpha 1 polypeptide
chr15_+_28202170 0.20 ENSDART00000077736
vtna
vitronectin a
chr4_-_9891874 0.20 ENSDART00000067193
adm2a
adrenomedullin 2a
chr21_+_43669943 0.20 ENSDART00000136025
tmlhe
trimethyllysine hydroxylase, epsilon
chr10_-_27741793 0.20 ENSDART00000129369
ENSDART00000192440
ENSDART00000189808
ENSDART00000138149
auts2a
si:dkey-33o22.1
autism susceptibility candidate 2a
si:dkey-33o22.1
chr2_+_3809226 0.20 ENSDART00000147261
egfra
epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
chr1_-_46984142 0.19 ENSDART00000125032
pknox1.2
pbx/knotted 1 homeobox 1.2
chr7_-_46777876 0.19 ENSDART00000193954
tshz3b
teashirt zinc finger homeobox 3b
chr4_+_54618332 0.18 ENSDART00000171824
si:ch211-227e10.2
si:ch211-227e10.2
chr12_+_38770654 0.18 ENSDART00000155367
kif19
kinesin family member 19
chr1_-_681116 0.18 ENSDART00000165894
adamts1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr4_+_20954929 0.16 ENSDART00000143674
nav3
neuron navigator 3
chr10_+_43039947 0.15 ENSDART00000193434
atg10
ATG10 autophagy related 10 homolog (S. cerevisiae)
chr14_+_35024521 0.15 ENSDART00000158634
ENSDART00000170631
ebf3a
early B cell factor 3a
chr7_+_27976448 0.15 ENSDART00000181026
tub
tubby bipartite transcription factor
chr1_-_9277986 0.15 ENSDART00000146065
ENSDART00000114876
ENSDART00000132812
ubn1
ubinuclein 1
chr4_+_30363474 0.15 ENSDART00000168421
si:dkey-199m13.7
si:dkey-199m13.7
chr5_+_19094462 0.14 ENSDART00000190596
unc13ba
unc-13 homolog Ba (C. elegans)
chr7_-_40959867 0.14 ENSDART00000174009
rbm33a
RNA binding motif protein 33a
chr6_-_53144336 0.14 ENSDART00000154429
gnai2b
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b
chr1_+_19515228 0.14 ENSDART00000103091
clrn2
clarin 2
chr10_+_36026576 0.13 ENSDART00000193786
hmgb1a
high mobility group box 1a
chr13_+_8604710 0.12 ENSDART00000091097
socs5b
suppressor of cytokine signaling 5b
chr5_-_201600 0.12 ENSDART00000158495
CABZ01088906.1

chr24_+_13735616 0.11 ENSDART00000184267
msc
musculin (activated B-cell factor-1)
chr24_-_26328721 0.11 ENSDART00000125468
apodb
apolipoprotein Db
chr9_-_9415000 0.11 ENSDART00000146210
si:ch211-214p13.9
si:ch211-214p13.9
chr8_-_49495584 0.11 ENSDART00000141691
opn7d
opsin 7, group member d
chr4_-_5366566 0.10 ENSDART00000150788
si:dkey-14d8.1
si:dkey-14d8.1
chr1_-_47431453 0.10 ENSDART00000101104
gja5b
gap junction protein, alpha 5b
chr6_-_53143667 0.09 ENSDART00000079694
gnai2b
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b
chr1_+_57151926 0.09 ENSDART00000152628
si:ch73-94k4.5
si:ch73-94k4.5
chr9_+_28103735 0.08 ENSDART00000007789
idh1
isocitrate dehydrogenase 1 (NADP+), soluble
chr23_-_11128601 0.08 ENSDART00000131232
cntn3a.2
contactin 3a, tandem duplicate 2
chr7_-_69983948 0.08 ENSDART00000185827
KCNIP4
potassium voltage-gated channel interacting protein 4
chr18_-_7677208 0.07 ENSDART00000092456
shank3a
SH3 and multiple ankyrin repeat domains 3a
chr17_+_20589553 0.07 ENSDART00000154447
si:ch73-288o11.4
si:ch73-288o11.4
chr1_+_56873359 0.07 ENSDART00000152713
si:ch211-152f2.2
si:ch211-152f2.2
chr18_-_14836862 0.07 ENSDART00000124843
mtss1la
metastasis suppressor 1-like a
chr3_+_59784632 0.06 ENSDART00000084729
pecam1
platelet/endothelial cell adhesion molecule 1
chr24_+_41915878 0.06 ENSDART00000171523
TMEM200C
transmembrane protein 200C
chr7_-_33248773 0.06 ENSDART00000052389
itga11a
integrin, alpha 11a
chr2_+_47623202 0.04 ENSDART00000154465
si:ch211-165b10.3
si:ch211-165b10.3
chr12_-_46145909 0.04 ENSDART00000139094
zgc:153932
zgc:153932
chr3_-_29508959 0.03 ENSDART00000055408
cyth4a
cytohesin 4a
chr1_+_56900580 0.03 ENSDART00000152568
si:ch211-152f2.3
si:ch211-152f2.3
chr1_+_55104376 0.03 ENSDART00000150492
aftpha
aftiphilin a
chr17_+_10501647 0.03 ENSDART00000140391
tyro3
TYRO3 protein tyrosine kinase
chr24_-_28893251 0.02 ENSDART00000042065
ENSDART00000003503
col11a1a
collagen, type XI, alpha 1a
chr16_-_31451282 0.02 ENSDART00000192354
csnk2a1
casein kinase 2, alpha 1 polypeptide
chr20_-_32188897 0.01 ENSDART00000133887
si:ch211-51a19.5
si:ch211-51a19.5
chr9_+_38075851 0.01 ENSDART00000135314
cacnb4a
calcium channel, voltage-dependent, beta 4a subunit
chr18_+_6155258 0.00 ENSDART00000092804
otogl
otogelin-like

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxb8a+hoxb8b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.2 GO:0015867 intracellular nucleoside transport(GO:0015859) purine nucleoside transmembrane transport(GO:0015860) purine nucleotide transport(GO:0015865) ATP transport(GO:0015867) purine ribonucleotide transport(GO:0015868) adenine nucleotide transport(GO:0051503) mitochondrial ATP transmembrane transport(GO:1990544)
0.4 1.7 GO:0010874 regulation of cholesterol efflux(GO:0010874)
0.3 1.5 GO:0003210 cardiac atrium formation(GO:0003210)
0.2 1.2 GO:0046677 response to antibiotic(GO:0046677)
0.2 0.9 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.2 0.7 GO:0045218 zonula adherens maintenance(GO:0045218)
0.2 1.3 GO:0060334 regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.2 1.2 GO:0035332 positive regulation of hippo signaling(GO:0035332)
0.2 0.8 GO:0098921 endocannabinoid signaling pathway(GO:0071926) retrograde trans-synaptic signaling by lipid(GO:0098920) retrograde trans-synaptic signaling by endocannabinoid(GO:0098921)
0.2 1.5 GO:1902262 apoptotic process involved in patterning of blood vessels(GO:1902262)
0.2 1.1 GO:0005513 detection of calcium ion(GO:0005513)
0.2 1.5 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.2 1.2 GO:0042984 amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.2 0.5 GO:0031630 regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630)
0.2 0.6 GO:0060092 regulation of synaptic transmission, glycinergic(GO:0060092)
0.2 1.1 GO:0098937 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937) anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971)
0.2 0.5 GO:0000212 meiotic spindle organization(GO:0000212)
0.1 0.6 GO:0070376 ERK5 cascade(GO:0070375) regulation of ERK5 cascade(GO:0070376) positive regulation of ERK5 cascade(GO:0070378)
0.1 0.6 GO:0034650 cortisol metabolic process(GO:0034650)
0.1 1.0 GO:0006032 chitin catabolic process(GO:0006032)
0.1 0.4 GO:0060300 microglial cell activation(GO:0001774) regulation of cytokine activity(GO:0060300) regulation of receptor binding(GO:1900120) regulation of chemokine activity(GO:1900136)
0.1 0.9 GO:0044857 membrane raft assembly(GO:0001765) membrane raft organization(GO:0031579) plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) caveola assembly(GO:0070836)
0.1 0.3 GO:0003242 growth involved in heart morphogenesis(GO:0003241) cardiac chamber ballooning(GO:0003242) cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
0.1 0.6 GO:0097477 spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477)
0.1 0.6 GO:0043201 response to leucine(GO:0043201) cellular response to leucine(GO:0071233) regulation of response to reactive oxygen species(GO:1901031)
0.1 1.4 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.1 0.3 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.1 0.3 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.1 0.4 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.1 0.7 GO:1990118 sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.1 0.4 GO:0099525 synaptic vesicle docking(GO:0016081) presynaptic dense core granule exocytosis(GO:0099525)
0.1 1.1 GO:0030007 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.1 0.9 GO:0040033 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0 0.4 GO:0042438 melanin biosynthetic process(GO:0042438)
0.0 0.3 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.0 1.5 GO:0051209 release of sequestered calcium ion into cytosol(GO:0051209)
0.0 0.4 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.4 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.0 0.9 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.2 GO:1902093 positive regulation of sperm motility(GO:1902093)
0.0 0.2 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.0 0.1 GO:0006097 glyoxylate cycle(GO:0006097)
0.0 0.3 GO:0002154 thyroid hormone mediated signaling pathway(GO:0002154)
0.0 0.3 GO:2000377 regulation of reactive oxygen species metabolic process(GO:2000377)
0.0 0.7 GO:1901379 regulation of potassium ion transmembrane transport(GO:1901379)
0.0 0.3 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 0.4 GO:0034625 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.2 GO:0035587 adenosine receptor signaling pathway(GO:0001973) purinergic receptor signaling pathway(GO:0035587) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0 1.2 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
0.0 0.6 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 0.6 GO:0003009 skeletal muscle contraction(GO:0003009)
0.0 0.2 GO:0060122 inner ear receptor stereocilium organization(GO:0060122)
0.0 0.3 GO:0061074 regulation of neural retina development(GO:0061074)
0.0 0.3 GO:0071456 cellular response to hypoxia(GO:0071456)
0.0 0.6 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.0 0.3 GO:0006536 glutamate metabolic process(GO:0006536)
0.0 0.3 GO:0070831 basement membrane assembly(GO:0070831)
0.0 0.2 GO:0072576 liver morphogenesis(GO:0072576)
0.0 0.4 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.1 GO:0097107 postsynaptic density assembly(GO:0097107) modulation of excitatory postsynaptic potential(GO:0098815) positive regulation of excitatory postsynaptic potential(GO:2000463)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.2 1.5 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.2 1.2 GO:0016586 RSC complex(GO:0016586)
0.1 0.7 GO:0005915 cell-cell adherens junction(GO:0005913) zonula adherens(GO:0005915)
0.1 0.3 GO:0098553 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.1 0.6 GO:0061700 GATOR2 complex(GO:0061700)
0.0 1.8 GO:0016342 catenin complex(GO:0016342)
0.0 0.7 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.1 GO:0019815 B cell receptor complex(GO:0019815)
0.0 0.2 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.8 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 1.4 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 1.8 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 0.9 GO:0044853 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.0 0.2 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.0 0.6 GO:0005861 troponin complex(GO:0005861)
0.0 1.2 GO:0005871 kinesin complex(GO:0005871)
0.0 0.3 GO:0043256 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.0 0.4 GO:0043195 terminal bouton(GO:0043195)
0.0 1.2 GO:0030018 Z disc(GO:0030018)
0.0 1.4 GO:0034703 cation channel complex(GO:0034703)
0.0 0.9 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 1.4 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.2 GO:0005471 ATP:ADP antiporter activity(GO:0005471)
0.3 1.5 GO:0048763 ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763)
0.2 1.2 GO:0008131 primary amine oxidase activity(GO:0008131)
0.2 0.9 GO:0004768 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215) palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.2 0.7 GO:0070097 delta-catenin binding(GO:0070097)
0.1 1.5 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 1.2 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.1 1.2 GO:0031433 telethonin binding(GO:0031433) FATZ binding(GO:0051373)
0.1 1.1 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.1 0.6 GO:0030298 receptor signaling protein tyrosine kinase activator activity(GO:0030298)
0.1 1.0 GO:0004568 chitinase activity(GO:0004568)
0.1 0.4 GO:0070412 R-SMAD binding(GO:0070412)
0.1 0.6 GO:0070728 leucine binding(GO:0070728)
0.1 1.7 GO:0016854 racemase and epimerase activity(GO:0016854)
0.1 0.8 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.1 0.2 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.1 1.1 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.1 0.7 GO:0015385 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.1 0.4 GO:0019992 diacylglycerol binding(GO:0019992)
0.1 0.2 GO:0019777 Atg12 transferase activity(GO:0019777)
0.0 0.3 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.6 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 0.5 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)
0.0 0.4 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 1.4 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.3 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 1.2 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.9 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.7 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 1.2 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.2 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 0.6 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0033764)
0.0 1.7 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.1 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.0 0.8 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 0.3 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.4 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.6 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.1 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.0 0.3 GO:0005165 nerve growth factor receptor binding(GO:0005163) neurotrophin receptor binding(GO:0005165)
0.0 0.5 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 1.4 GO:0045296 cadherin binding(GO:0045296)
0.0 0.4 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.3 GO:0008143 poly(A) binding(GO:0008143)
0.0 0.8 GO:0071949 FAD binding(GO:0071949)
0.0 0.2 GO:0019211 phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542)
0.0 0.1 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.4 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.2 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 1.5 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 0.4 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 2.2 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.0 0.6 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.8 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.2 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.0 0.2 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.6 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.4 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0 0.3 REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins