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PRJEB1986: zebrafish developmental stages transcriptome

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Results for irf1b+irf2+irf2a

Z-value: 1.67

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Transcription factors associated with irf1b+irf2+irf2a

Gene Symbol Gene ID Gene Info
irf2a
ENSDARG00000007387 interferon regulatory factor 2a
irf2
ENSDARG00000040465 interferon regulatory factor 2
irf1b
ENSDARG00000043249 interferon regulatory factor 1b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
irf2adr11_v1_chr1_+_39865748_398657530.571.1e-02Click!
irf1bdr11_v1_chr21_+_45626136_456261360.541.6e-02Click!
irf2dr11_v1_chr14_-_4120636_41206360.213.9e-01Click!

Activity profile of irf1b+irf2+irf2a motif

Sorted Z-values of irf1b+irf2+irf2a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr9_+_30387930 3.32 ENSDART00000112827
si:dkey-18p12.4
si:dkey-18p12.4
chr8_-_40555340 2.72 ENSDART00000163348
NPC1L1
NPC1 like intracellular cholesterol transporter 1
chr18_-_38270430 2.16 ENSDART00000139519
caprin1b
cell cycle associated protein 1b
chr1_+_53377432 1.98 ENSDART00000177581
ucp1
uncoupling protein 1
chr24_+_12945803 1.97 ENSDART00000005105
psme1
proteasome activator subunit 1
chr11_+_43043171 1.91 ENSDART00000180344
CABZ01092982.1

chr9_+_1138323 1.87 ENSDART00000190352
ENSDART00000190387
slc15a1a
solute carrier family 15 (oligopeptide transporter), member 1a
chr11_-_472547 1.78 ENSDART00000005923
zgc:77375
zgc:77375
chr1_-_47089818 1.78 ENSDART00000132378
itsn1
intersectin 1 (SH3 domain protein)
chr11_-_23332592 1.78 ENSDART00000125024
golt1a
golgi transport 1A
chr21_-_40557281 1.77 ENSDART00000172327
taok1b
TAO kinase 1b
chr18_+_26422124 1.66 ENSDART00000060245
ctsh
cathepsin H
chr19_-_7115229 1.62 ENSDART00000001930
psmb13a
proteasome subunit beta 13a
chr22_+_5687615 1.59 ENSDART00000133241
ENSDART00000019854
ENSDART00000138102
dnase1l4.2
deoxyribonuclease 1 like 4, tandem duplicate 2
chr11_-_20096018 1.58 ENSDART00000030420
ogfrl2
opioid growth factor receptor-like 2
chr17_-_15149192 1.58 ENSDART00000180511
ENSDART00000103405
gch1
GTP cyclohydrolase 1
chr10_+_17776981 1.57 ENSDART00000141693
ccl19b
chemokine (C-C motif) ligand 19b
chr9_-_44939104 1.57 ENSDART00000192903
vil1
villin 1
chr19_+_7115223 1.54 ENSDART00000001359
psmb12
proteasome subunit beta 12
chr21_-_22648007 1.51 ENSDART00000121788
gig2l
grass carp reovirus (GCRV)-induced gene 2l
chr17_-_29192987 1.50 ENSDART00000164302
sptbn5
spectrin, beta, non-erythrocytic 5
chr22_+_29990448 1.48 ENSDART00000165313
si:dkey-286j15.3
si:dkey-286j15.3
chr13_-_3351708 1.46 ENSDART00000042875
si:ch73-193i2.2
si:ch73-193i2.2
chr12_+_35650321 1.44 ENSDART00000190446
BX255898.1

chr22_+_19290199 1.44 ENSDART00000148173
si:dkey-21e2.15
si:dkey-21e2.15
chr9_-_43001898 1.38 ENSDART00000138515
ttn.2
titin, tandem duplicate 2
chr5_+_4338874 1.36 ENSDART00000141866
sat1a.1
spermidine/spermine N1-acetyltransferase 1a, duplicate 1
chr13_-_37631092 1.33 ENSDART00000108855
si:dkey-188i13.7
si:dkey-188i13.7
chr22_+_19289970 1.30 ENSDART00000137976
ENSDART00000132386
si:dkey-21e2.15
si:dkey-21e2.15
chr10_-_22095505 1.29 ENSDART00000140210
ponzr10
plac8 onzin related protein 10
chr24_+_15277216 1.28 ENSDART00000081449
socs6a
suppressor of cytokine signaling 6a
chr13_+_13681681 1.28 ENSDART00000057825
cfd
complement factor D (adipsin)
chr15_-_17868870 1.27 ENSDART00000170950
atf5b
activating transcription factor 5b
chr20_+_49787584 1.26 ENSDART00000193458
ENSDART00000181511
ENSDART00000185850
ENSDART00000185613
ENSDART00000191671
CABZ01078261.1

chr9_-_18215644 1.26 ENSDART00000145876
epsti1
epithelial stromal interaction 1
chr4_-_240737 1.25 ENSDART00000166186
RERG
si:cabz01085950.1
chr11_-_45385803 1.23 ENSDART00000173329
trappc10
trafficking protein particle complex 10
chr11_-_2250767 1.22 ENSDART00000018131
hnrnpa1a
heterogeneous nuclear ribonucleoprotein A1a
chr17_-_23609210 1.22 ENSDART00000064003
ifit15
interferon-induced protein with tetratricopeptide repeats 15
chr4_+_70782916 1.20 ENSDART00000187960
si:dkey-16p6.1
si:dkey-16p6.1
chr5_+_36614196 1.19 ENSDART00000150574
nova1
neuro-oncological ventral antigen 1
chr1_-_30510839 1.19 ENSDART00000168189
ENSDART00000174868
igf2bp2b
insulin-like growth factor 2 mRNA binding protein 2b
chr21_+_5494561 1.17 ENSDART00000169728
ly6m3
lymphocyte antigen 6 family member M3
chr1_-_7930679 1.17 ENSDART00000146090
si:dkey-79f11.10
si:dkey-79f11.10
chr5_-_12701603 1.08 ENSDART00000091124
aifm3
apoptosis-inducing factor, mitochondrion-associated, 3
chr16_-_46587938 1.07 ENSDART00000181433
BX323793.1

chr20_+_32481348 1.07 ENSDART00000185018
ostm1
osteopetrosis associated transmembrane protein 1
chr15_-_15227541 1.06 ENSDART00000184787
rrp8
ribosomal RNA processing 8, methyltransferase, homolog (yeast)
chr14_-_2933185 1.05 ENSDART00000161677
ENSDART00000162446
ENSDART00000109378
si:dkey-201i24.6
si:dkey-201i24.6
chr20_+_34605044 1.05 ENSDART00000153376
si:ch211-242b18.1
si:ch211-242b18.1
chr15_-_44077937 1.05 ENSDART00000110112
lamtor1
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
chr1_-_8141135 1.05 ENSDART00000152295
FAM83G
si:dkeyp-9d4.4
chr20_-_4793450 1.05 ENSDART00000053870
galca
galactosylceramidase a
chr9_-_27442339 1.04 ENSDART00000138602
stxbp5l
syntaxin binding protein 5-like
chr21_+_20901505 1.03 ENSDART00000132741
c7b
complement component 7b
chr25_-_12804450 1.03 ENSDART00000169717
ca5a
carbonic anhydrase Va
chr23_+_45229198 1.02 ENSDART00000172445
ttc39b
tetratricopeptide repeat domain 39B
chr25_+_35189555 1.02 ENSDART00000044453
ano5a
anoctamin 5a
chr2_-_42035250 1.02 ENSDART00000056460
ENSDART00000140788
gbp1
guanylate binding protein 1
chr1_-_56948694 1.01 ENSDART00000152597
si:ch211-1f22.1
si:ch211-1f22.1
chr20_+_44582318 1.00 ENSDART00000149000
ENSDART00000149775
ENSDART00000085416
atad2b
ATPase family, AAA domain containing 2B
chr6_-_57539141 0.99 ENSDART00000156967
itcha
itchy E3 ubiquitin protein ligase a
chr8_+_50983551 0.97 ENSDART00000142061
si:dkey-32e23.4
si:dkey-32e23.4
chr23_-_21763598 0.97 ENSDART00000145408
vps13d
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr6_+_59029485 0.97 ENSDART00000050140
CABZ01088367.1

chr3_-_53508580 0.97 ENSDART00000073978
zgc:171711
zgc:171711
chr1_-_52201266 0.97 ENSDART00000143805
ENSDART00000023757
rab3da
RAB3D, member RAS oncogene family, a
chr7_-_40656148 0.96 ENSDART00000142315
nom1
nucleolar protein with MIF4G domain 1
chr1_+_38858399 0.96 ENSDART00000165454
CU915762.1

chr1_-_47161996 0.96 ENSDART00000053153
mhc1zba
major histocompatibility complex class I ZBA
chr6_-_45869127 0.96 ENSDART00000062459
ENSDART00000180563
rbm19
RNA binding motif protein 19
chr25_-_12803723 0.95 ENSDART00000158787
ca5a
carbonic anhydrase Va
chr17_-_23416897 0.95 ENSDART00000163391
si:ch211-149k12.3
si:ch211-149k12.3
chr23_-_37575030 0.95 ENSDART00000031875
tor1l3
torsin family 1 like 3
chr15_-_14083028 0.94 ENSDART00000147796
ENSDART00000043492
ENSDART00000133080
trappc6bl
trafficking protein particle complex 6b-like
chr11_+_1584747 0.93 ENSDART00000154583
si:dkey-40c23.2
si:dkey-40c23.2
chr9_+_42269059 0.93 ENSDART00000113435
si:dkey-10c21.1
si:dkey-10c21.1
chr22_-_5518117 0.92 ENSDART00000164613
CABZ01064972.1

chr16_-_2650341 0.92 ENSDART00000128169
ENSDART00000155432
ENSDART00000103722
lyplal1
lysophospholipase-like 1
chr15_-_43995028 0.92 ENSDART00000172485
ENSDART00000186320
nlrc3l
NLR family, CARD domain containing 3-like
chr12_+_17436904 0.91 ENSDART00000079130
atad1b
ATPase family, AAA domain containing 1b
chr8_-_27687095 0.90 ENSDART00000086946
mov10b.1
Moloney leukemia virus 10b, tandem duplicate 1
chr25_-_10503043 0.90 ENSDART00000155404
cox8b
cytochrome c oxidase subunit 8b
chr6_+_38427357 0.89 ENSDART00000148678
gabrb3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr3_+_832788 0.89 ENSDART00000193025
FP102888.2

chr9_-_14273652 0.89 ENSDART00000135458
abcb6b
ATP-binding cassette, sub-family B (MDR/TAP), member 6b
chr9_-_19762801 0.89 ENSDART00000146841
si:ch211-141e20.2
si:ch211-141e20.2
chr4_-_31993240 0.89 ENSDART00000167842
si:dkey-72l17.5
si:dkey-72l17.5
chr1_-_47071979 0.89 ENSDART00000160817
itsn1
intersectin 1 (SH3 domain protein)
chr17_-_35076730 0.88 ENSDART00000146590
mboat2a
membrane bound O-acyltransferase domain containing 2a
chr16_+_29555801 0.88 ENSDART00000169425
ensab
endosulfine alpha b
chr19_+_1414604 0.87 ENSDART00000159024
btr29
bloodthirsty-related gene family, member 29
chr16_-_25829779 0.87 ENSDART00000086301
irge4
immunity-related GTPase family, e4
chr23_+_26142613 0.87 ENSDART00000165046
ptpn22
protein tyrosine phosphatase, non-receptor type 22
chr12_+_20641102 0.86 ENSDART00000152964
calcoco2
calcium binding and coiled-coil domain 2
chr15_-_1003553 0.86 ENSDART00000154195
si:dkey-77f5.6
si:dkey-77f5.6
chr13_+_7578111 0.85 ENSDART00000175431
gbf1
golgi brefeldin A resistant guanine nucleotide exchange factor 1
chr15_-_29162193 0.85 ENSDART00000138449
ENSDART00000099885
xaf1
XIAP associated factor 1
chr1_-_51266394 0.85 ENSDART00000164016
kif16ba
kinesin family member 16Ba
chr13_-_37620091 0.85 ENSDART00000135875
ENSDART00000193270
ENSDART00000018064
zgc:152791
zgc:152791
chr12_-_4598237 0.83 ENSDART00000152489
irf3
interferon regulatory factor 3
chr5_-_57723929 0.83 ENSDART00000144237
gig2p
grass carp reovirus (GCRV)-induced gene 2p
chr2_+_21090317 0.83 ENSDART00000109568
ENSDART00000139633
pip4k2ab
phosphatidylinositol-5-phosphate 4-kinase, type II, alpha b
chr1_+_58424507 0.83 ENSDART00000114197
si:ch73-236c18.3
si:ch73-236c18.3
chr4_+_34417403 0.83 ENSDART00000186032
ENSDART00000167909
si:ch211-246b8.2
si:ch211-246b8.2
chr10_-_45229877 0.83 ENSDART00000169281
pargl
poly (ADP-ribose) glycohydrolase, like
chr4_-_26095755 0.82 ENSDART00000100611
ENSDART00000191266
si:ch211-244b2.3
si:ch211-244b2.3
chr15_+_17100697 0.82 ENSDART00000183565
ENSDART00000123197
relb
v-rel avian reticuloendotheliosis viral oncogene homolog B
chr7_-_72067475 0.82 ENSDART00000017763
LO018380.1

chr13_+_17694845 0.81 ENSDART00000079778
ifit8
interferon-induced protein with tetratricopeptide repeats 8
chr5_+_8256574 0.81 ENSDART00000171343
FP102192.1

chr15_+_2421729 0.80 ENSDART00000082294
ENSDART00000156428
hephl1a
hephaestin-like 1a
chr2_-_59376735 0.80 ENSDART00000193624
ftr38
finTRIM family, member 38
chr1_-_12397258 0.80 ENSDART00000144596
sclt1
sodium channel and clathrin linker 1
chr15_-_20180475 0.79 ENSDART00000048183
exoc3l2b
exocyst complex component 3-like 2b
chr3_+_19446997 0.78 ENSDART00000079352
zgc:123297
zgc:123297
chr21_+_34992550 0.78 ENSDART00000109041
ENSDART00000135400
tmprss15
transmembrane protease, serine 15
chr5_+_52625975 0.78 ENSDART00000170341
ENSDART00000168317
apba1a
amyloid beta (A4) precursor protein-binding, family A, member 1a
chr2_-_59157790 0.77 ENSDART00000192303
ENSDART00000159362
ftr32
finTRIM family, member 32
chr2_-_32688905 0.76 ENSDART00000041146
nrbp2a
nuclear receptor binding protein 2a
chr11_+_42478184 0.76 ENSDART00000089963
zgc:110286
zgc:110286
chr15_-_47929455 0.76 ENSDART00000064462
psma6l
proteasome subunit alpha 6, like
chr2_-_30734098 0.76 ENSDART00000133769
rp1
retinitis pigmentosa 1 (autosomal dominant)
chr1_-_25177086 0.75 ENSDART00000144711
ENSDART00000177225
tmem154
transmembrane protein 154
chr23_-_37835794 0.75 ENSDART00000137358
cd40
CD40 molecule, TNF receptor superfamily member 5
chr23_-_12735434 0.75 ENSDART00000139166
si:dkey-96f10.1
si:dkey-96f10.1
chr16_+_41570653 0.75 ENSDART00000102665
aste1a
asteroid homolog 1a
chr4_-_12795030 0.75 ENSDART00000150427
b2m
beta-2-microglobulin
chr22_+_1615691 0.75 ENSDART00000171555
si:ch211-255f4.13
si:ch211-255f4.13
chr12_-_26153101 0.74 ENSDART00000076051
opn4b
opsin 4b
chr11_+_2596667 0.74 ENSDART00000175330
dnajc14
DnaJ (Hsp40) homolog, subfamily C, member 14
chr1_-_2457546 0.74 ENSDART00000103795
ggact.1
gamma-glutamylamine cyclotransferase, tandem duplicate 1
chr12_+_27285994 0.73 ENSDART00000087204
dusp3a
dual specificity phosphatase 3a
chr8_-_38616712 0.73 ENSDART00000141827
si:ch211-198d23.1
si:ch211-198d23.1
chr17_-_23631400 0.73 ENSDART00000079563
fas
Fas cell surface death receptor
chr9_-_19699728 0.73 ENSDART00000166780
si:ch211-141e20.2
si:ch211-141e20.2
chr8_-_36469117 0.73 ENSDART00000111240
mhc2dab
major histocompatibility complex class II DAB gene
chr22_-_6054749 0.72 ENSDART00000191603
CU468041.2

chr18_-_38270077 0.71 ENSDART00000185546
caprin1b
cell cycle associated protein 1b
chr1_+_7956030 0.70 ENSDART00000159655
CR855320.1

chr18_+_13248956 0.70 ENSDART00000080709
plcg2
phospholipase C, gamma 2
chr10_-_7913591 0.69 ENSDART00000139661
slc35e4
solute carrier family 35, member E4
chr22_-_5958066 0.69 ENSDART00000145821
si:rp71-36a1.3
si:rp71-36a1.3
chr2_+_42005475 0.69 ENSDART00000056461
gbp2
guanylate binding protein 2
chr7_+_8324506 0.69 ENSDART00000168110
si:dkey-185m8.2
si:dkey-185m8.2
chr1_-_36771712 0.69 ENSDART00000148386
prmt9
protein arginine methyltransferase 9
chr16_+_53710416 0.69 ENSDART00000155929
nod1
nucleotide-binding oligomerization domain containing 1
chr22_-_29242347 0.68 ENSDART00000040761
pvalb7
parvalbumin 7
chr7_-_6444011 0.68 ENSDART00000173010
zgc:112234
zgc:112234
chr22_+_31023205 0.68 ENSDART00000111561
zmp:0000000735
zmp:0000000735
chr23_-_12906228 0.68 ENSDART00000138807
ndnl2
necdin-like 2
chr17_+_35362851 0.67 ENSDART00000137659
cmpk2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr4_-_76079075 0.67 ENSDART00000158469
si:ch211-232d10.3
si:ch211-232d10.3
chr16_+_26439939 0.67 ENSDART00000143073
trim35-28
tripartite motif containing 35-28
chr1_+_40148193 0.67 ENSDART00000138072
zgc:194443
zgc:194443
chr12_-_11560794 0.66 ENSDART00000149098
ENSDART00000169975
plekha1b
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1b
chr17_-_35361322 0.66 ENSDART00000019617
rsad2
radical S-adenosyl methionine domain containing 2
chr20_+_4793516 0.66 ENSDART00000053875
lgals8a
galectin 8a
chr16_+_48678655 0.66 ENSDART00000150156
tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr5_-_38179220 0.66 ENSDART00000147701
si:ch211-284e13.11
si:ch211-284e13.11
chr13_+_7387822 0.66 ENSDART00000148240
exoc3l4
exocyst complex component 3-like 4
chr5_+_38662125 0.65 ENSDART00000136949
si:dkey-58f10.13
si:dkey-58f10.13
chr2_+_9757453 0.64 ENSDART00000168972
pcyt1aa
phosphate cytidylyltransferase 1, choline, alpha a
chr15_-_37867995 0.64 ENSDART00000192698
si:dkey-238d18.4
si:dkey-238d18.4
chr4_-_26108053 0.64 ENSDART00000066951
si:ch211-244b2.4
si:ch211-244b2.4
chr23_+_46183410 0.64 ENSDART00000167596
ENSDART00000151149
ENSDART00000150896
btr31
bloodthirsty-related gene family, member 31
chr14_-_45967981 0.64 ENSDART00000188062
macrod1
MACRO domain containing 1
chr4_+_53268458 0.64 ENSDART00000165335
si:dkey-250k10.1
si:dkey-250k10.1
chr3_-_24093144 0.63 ENSDART00000103982
nfe2l1a
nuclear factor, erythroid 2-like 1a
chr3_-_4455951 0.63 ENSDART00000193908
ENSDART00000074077
trim35-3
tripartite motif containing 35-3
chr23_+_21566828 0.63 ENSDART00000134741
ENSDART00000111966
arhgef10lb
Rho guanine nucleotide exchange factor (GEF) 10-like b
chr20_+_715739 0.63 ENSDART00000136768
myo6a
myosin VIa
chr2_+_26656283 0.63 ENSDART00000133202
ENSDART00000099208
asph
aspartate beta-hydroxylase
chr15_-_36369743 0.63 ENSDART00000155942
si:dkey-23k10.3
si:dkey-23k10.3
chr5_-_4923473 0.62 ENSDART00000134585
zbtb43
zinc finger and BTB domain containing 43
chr16_-_51271962 0.62 ENSDART00000164021
ENSDART00000046420
serpinb1l1
serpin peptidase inhibitor, clade B (ovalbumin), member 1, like 1
chr25_+_245018 0.62 ENSDART00000155344
zgc:92481
zgc:92481
chr15_-_36357889 0.61 ENSDART00000156377
si:dkey-23k10.5
si:dkey-23k10.5
chr18_-_38270596 0.61 ENSDART00000098889
caprin1b
cell cycle associated protein 1b
chr9_+_12948511 0.60 ENSDART00000135797
si:dkey-230p4.1
si:dkey-230p4.1
chr2_-_47870649 0.59 ENSDART00000142854
ftr05
finTRIM family, member 5
chr5_+_38619813 0.59 ENSDART00000133314
si:ch211-271e10.3
si:ch211-271e10.3
chr19_+_23296616 0.58 ENSDART00000134567
irgf1
immunity-related GTPase family, f1
chr3_-_43821381 0.58 ENSDART00000166021
snn
stannin
chr4_-_17669881 0.58 ENSDART00000066997
dram1
DNA-damage regulated autophagy modulator 1
chr5_-_21030934 0.58 ENSDART00000133461
ENSDART00000098667
camk2b1
calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1
chr4_+_68476490 0.57 ENSDART00000168543
si:dkey-237g15.2
si:dkey-237g15.2
chr22_-_6941098 0.57 ENSDART00000105864
zgc:171500
zgc:171500
chr17_+_50524573 0.57 ENSDART00000187974
CR382385.1

chr12_+_31608905 0.57 ENSDART00000152874
ENSDART00000152996
CR352342.1
cpn1

carboxypeptidase N, polypeptide 1
chr3_-_336299 0.57 ENSDART00000105021
mhc1zfa
major histocompatibility complex class I ZFA
chr9_+_51147764 0.57 ENSDART00000188480
ifih1
interferon induced with helicase C domain 1
chr4_+_70967639 0.56 ENSDART00000159230
si:dkeyp-80d11.12
si:dkeyp-80d11.12
chr8_-_51404806 0.56 ENSDART00000060625
lgi3
leucine-rich repeat LGI family, member 3
chr13_-_42066299 0.56 ENSDART00000111536
rmdn2
regulator of microtubule dynamics 2
chr4_-_50933168 0.56 ENSDART00000150296
si:ch211-208f21.3
si:ch211-208f21.3
chr8_+_1187928 0.56 ENSDART00000127252
slc35d2
solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2
chr1_+_11881559 0.55 ENSDART00000166981
snx8b
sorting nexin 8b
chr3_-_40136743 0.55 ENSDART00000149546
myo15aa
myosin XVAa
chr3_-_32472155 0.55 ENSDART00000156280
si:ch211-195b15.7
si:ch211-195b15.7

Network of associatons between targets according to the STRING database.

First level regulatory network of irf1b+irf2+irf2a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.4 1.6 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.4 1.6 GO:0072673 lamellipodium morphogenesis(GO:0072673) regulation of lamellipodium morphogenesis(GO:2000392)
0.3 1.4 GO:0009447 polyamine catabolic process(GO:0006598) putrescine catabolic process(GO:0009447)
0.2 0.7 GO:0045191 response to protozoan(GO:0001562) TRIF-dependent toll-like receptor signaling pathway(GO:0035666) defense response to protozoan(GO:0042832) regulation of isotype switching(GO:0045191) positive regulation of isotype switching(GO:0045830)
0.2 1.5 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.2 2.0 GO:1990845 adaptive thermogenesis(GO:1990845)
0.2 0.9 GO:0032728 interferon-beta production(GO:0032608) regulation of interferon-beta production(GO:0032648) positive regulation of interferon-beta production(GO:0032728)
0.2 0.7 GO:0009211 pyrimidine deoxyribonucleoside triphosphate metabolic process(GO:0009211)
0.2 1.9 GO:0006857 oligopeptide transport(GO:0006857)
0.2 1.4 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.2 0.9 GO:0071763 nuclear membrane organization(GO:0071763)
0.2 0.9 GO:0014005 microglia development(GO:0014005)
0.2 0.7 GO:0070227 lymphocyte apoptotic process(GO:0070227)
0.2 0.9 GO:0035279 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.2 1.1 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.2 0.5 GO:0061400 positive regulation of transcription from RNA polymerase II promoter in response to calcium ion(GO:0061400)
0.2 1.1 GO:0001919 regulation of receptor recycling(GO:0001919)
0.2 0.7 GO:0002478 antigen processing and presentation of exogenous peptide antigen(GO:0002478) antigen processing and presentation of exogenous antigen(GO:0019884) antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
0.2 1.0 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.1 1.5 GO:0051601 exocyst localization(GO:0051601)
0.1 0.8 GO:0044819 mitotic G1/S transition checkpoint(GO:0044819)
0.1 1.0 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.1 0.4 GO:0019062 virion attachment to host cell(GO:0019062) adhesion of symbiont to host(GO:0044406) adhesion of symbiont to host cell(GO:0044650)
0.1 0.6 GO:0018197 peptidyl-aspartic acid modification(GO:0018197) peptidyl-aspartic acid hydroxylation(GO:0042264)
0.1 0.9 GO:0031179 peptide modification(GO:0031179)
0.1 0.4 GO:2000660 regulation of interleukin-1-mediated signaling pathway(GO:2000659) negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.1 1.6 GO:0000737 DNA catabolic process, endonucleolytic(GO:0000737)
0.1 0.3 GO:0070589 cell wall biogenesis(GO:0042546) cell wall macromolecule biosynthetic process(GO:0044038) cellular component macromolecule biosynthetic process(GO:0070589)
0.1 0.3 GO:0060623 regulation of chromosome condensation(GO:0060623)
0.1 0.4 GO:0015677 copper ion import(GO:0015677)
0.1 1.4 GO:0048769 sarcomerogenesis(GO:0048769)
0.1 0.3 GO:1902042 regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902041) negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042)
0.1 0.3 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.1 0.8 GO:1901678 heme transport(GO:0015886) iron coordination entity transport(GO:1901678)
0.1 0.2 GO:1902571 regulation of serine-type peptidase activity(GO:1902571)
0.1 1.3 GO:0006825 copper ion transport(GO:0006825)
0.1 0.7 GO:0035188 hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.1 0.4 GO:0036371 protein localization to T-tubule(GO:0036371)
0.1 0.4 GO:0043420 anthranilate metabolic process(GO:0043420)
0.1 1.5 GO:1990035 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.1 0.9 GO:0098734 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.1 0.3 GO:0070587 regulation of cell-cell adhesion involved in gastrulation(GO:0070587)
0.1 0.9 GO:0071501 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.1 0.4 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.1 0.7 GO:0034122 negative regulation of toll-like receptor signaling pathway(GO:0034122)
0.1 2.2 GO:2000045 regulation of G1/S transition of mitotic cell cycle(GO:2000045)
0.1 0.4 GO:1990108 protein linear deubiquitination(GO:1990108)
0.1 0.4 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.1 1.0 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.1 0.4 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.1 0.6 GO:0035479 angioblast cell migration from lateral mesoderm to midline(GO:0035479)
0.1 0.8 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.1 1.3 GO:0097194 execution phase of apoptosis(GO:0097194)
0.1 0.3 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504)
0.1 0.5 GO:0001958 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.1 0.5 GO:0070475 rRNA base methylation(GO:0070475)
0.1 1.6 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.2 GO:0090161 Golgi ribbon formation(GO:0090161)
0.0 0.1 GO:1901533 negative regulation of hematopoietic progenitor cell differentiation(GO:1901533)
0.0 0.3 GO:0051793 medium-chain fatty acid metabolic process(GO:0051791) medium-chain fatty acid catabolic process(GO:0051793)
0.0 0.7 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 2.9 GO:0051607 defense response to virus(GO:0051607)
0.0 0.4 GO:0044528 regulation of mitochondrial mRNA stability(GO:0044528)
0.0 0.3 GO:0097107 postsynaptic density assembly(GO:0097107) modulation of excitatory postsynaptic potential(GO:0098815) positive regulation of excitatory postsynaptic potential(GO:2000463)
0.0 0.2 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.0 0.4 GO:0043363 nucleate erythrocyte differentiation(GO:0043363)
0.0 0.1 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.0 1.7 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.0 0.2 GO:0089700 protein kinase D signaling(GO:0089700)
0.0 1.0 GO:0019835 cytolysis(GO:0019835)
0.0 0.4 GO:0046512 diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.0 2.0 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 3.6 GO:0017148 negative regulation of translation(GO:0017148)
0.0 0.9 GO:0038061 NIK/NF-kappaB signaling(GO:0038061)
0.0 0.7 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.0 0.2 GO:0045337 farnesyl diphosphate biosynthetic process(GO:0045337)
0.0 0.5 GO:0032098 regulation of appetite(GO:0032098)
0.0 0.1 GO:0071514 genetic imprinting(GO:0071514)
0.0 0.5 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.0 0.2 GO:0070571 negative regulation of axon regeneration(GO:0048681) negative regulation of neuron projection regeneration(GO:0070571)
0.0 0.1 GO:0043550 regulation of lipid kinase activity(GO:0043550) regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.0 1.0 GO:0070534 protein K63-linked ubiquitination(GO:0070534)
0.0 0.3 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055)
0.0 0.8 GO:0035308 negative regulation of dephosphorylation(GO:0035305) negative regulation of protein dephosphorylation(GO:0035308)
0.0 0.4 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 1.5 GO:0051693 actin filament capping(GO:0051693)
0.0 0.2 GO:0097340 inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341)
0.0 0.1 GO:0071918 urea transmembrane transport(GO:0071918)
0.0 0.8 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 1.0 GO:0072114 pronephros morphogenesis(GO:0072114)
0.0 1.0 GO:0050708 regulation of protein secretion(GO:0050708)
0.0 1.0 GO:0048546 digestive tract morphogenesis(GO:0048546)
0.0 0.4 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
0.0 0.9 GO:0009225 nucleotide-sugar metabolic process(GO:0009225)
0.0 0.2 GO:0007220 Notch receptor processing(GO:0007220)
0.0 0.2 GO:0031048 chromatin silencing by small RNA(GO:0031048)
0.0 0.2 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.0 1.0 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 1.7 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 0.9 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 1.1 GO:1901800 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)
0.0 0.3 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 0.4 GO:0019882 antigen processing and presentation(GO:0019882)
0.0 0.7 GO:0019432 triglyceride biosynthetic process(GO:0019432)
0.0 0.9 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.3 GO:0044154 histone H3-K14 acetylation(GO:0044154)
0.0 0.4 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.2 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.0 0.1 GO:0036149 phosphatidylinositol acyl-chain remodeling(GO:0036149)
0.0 0.5 GO:0010507 negative regulation of autophagy(GO:0010507)
0.0 0.1 GO:0048660 regulation of smooth muscle cell proliferation(GO:0048660) negative regulation of smooth muscle cell proliferation(GO:0048662)
0.0 0.1 GO:0034627 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.0 0.3 GO:0051127 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 0.5 GO:0070593 dendrite self-avoidance(GO:0070593)
0.0 0.5 GO:0043488 regulation of mRNA stability(GO:0043488)
0.0 0.1 GO:0072088 renal tubule morphogenesis(GO:0061333) nephron tubule morphogenesis(GO:0072078) nephron epithelium morphogenesis(GO:0072088)
0.0 1.2 GO:0046474 glycerophospholipid biosynthetic process(GO:0046474)
0.0 0.0 GO:0055057 neuroblast division(GO:0055057)
0.0 1.8 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 0.8 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.0 0.9 GO:1902668 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.0 1.1 GO:0046834 lipid phosphorylation(GO:0046834) phosphatidylinositol phosphorylation(GO:0046854)
0.0 1.2 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.3 GO:0097178 ruffle assembly(GO:0097178)
0.0 0.5 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.2 GO:0070828 heterochromatin organization(GO:0070828)
0.0 0.2 GO:0038180 nerve growth factor signaling pathway(GO:0038180)
0.0 0.6 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.0 1.0 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
0.0 0.3 GO:0030042 actin filament depolymerization(GO:0030042)
0.0 0.5 GO:1902036 regulation of hematopoietic stem cell differentiation(GO:1902036)
0.0 0.6 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.7 GO:0035082 axoneme assembly(GO:0035082)
0.0 0.4 GO:0046890 regulation of lipid biosynthetic process(GO:0046890)
0.0 0.8 GO:0046488 phosphatidylinositol metabolic process(GO:0046488)
0.0 1.1 GO:0036503 ERAD pathway(GO:0036503)
0.0 1.5 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.5 GO:0030050 vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.0 0.4 GO:0035336 long-chain fatty-acyl-CoA metabolic process(GO:0035336)
0.0 0.2 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.0 GO:0008537 proteasome activator complex(GO:0008537)
0.3 1.6 GO:0032433 filopodium tip(GO:0032433)
0.3 1.5 GO:1990071 TRAPPII protein complex(GO:1990071)
0.2 1.1 GO:0033553 rDNA heterochromatin(GO:0033553)
0.2 1.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.2 0.7 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.2 1.1 GO:0071986 Ragulator complex(GO:0071986)
0.2 0.8 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.1 1.0 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 0.4 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.1 0.9 GO:0030008 TRAPP complex(GO:0030008)
0.1 1.0 GO:0005579 membrane attack complex(GO:0005579)
0.1 3.2 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 0.4 GO:0038039 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor heterodimeric complex(GO:0038039) G-protein coupled receptor complex(GO:0097648)
0.0 0.9 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 0.6 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.4 GO:0071797 LUBAC complex(GO:0071797)
0.0 0.4 GO:0031211 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.1 GO:0005775 vacuolar lumen(GO:0005775) lysosomal lumen(GO:0043202)
0.0 0.2 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0 0.1 GO:0044326 dendritic spine neck(GO:0044326) dendritic filopodium(GO:1902737)
0.0 0.3 GO:0016586 RSC complex(GO:0016586)
0.0 0.3 GO:0030130 trans-Golgi network transport vesicle membrane(GO:0012510) clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 0.8 GO:0005839 proteasome core complex(GO:0005839)
0.0 0.9 GO:0043186 P granule(GO:0043186)
0.0 0.9 GO:1902711 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 1.4 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.2 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 0.5 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.4 GO:0030315 T-tubule(GO:0030315)
0.0 1.1 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.2 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024) nuclear cyclin-dependent protein kinase holoenzyme complex(GO:0019908)
0.0 4.1 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.1 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 0.3 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.1 GO:0005880 nuclear microtubule(GO:0005880)
0.0 0.5 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.1 GO:0000306 extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.0 0.6 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 1.4 GO:0000786 nucleosome(GO:0000786)
0.0 1.9 GO:0008021 synaptic vesicle(GO:0008021)
0.0 0.0 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.0 0.2 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.1 GO:0043194 axon initial segment(GO:0043194)
0.0 0.2 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 1.0 GO:0031201 SNARE complex(GO:0031201)
0.0 0.6 GO:0031902 late endosome membrane(GO:0031902)
0.0 0.9 GO:0005871 kinesin complex(GO:0005871)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.0 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.3 2.0 GO:0061133 endopeptidase activator activity(GO:0061133)
0.3 0.9 GO:0032574 5'-3' RNA helicase activity(GO:0032574)
0.3 1.9 GO:0071916 dipeptide transporter activity(GO:0042936) dipeptide transmembrane transporter activity(GO:0071916)
0.2 0.7 GO:0009041 uridylate kinase activity(GO:0009041)
0.2 1.1 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.2 0.8 GO:0004649 poly(ADP-ribose) glycohydrolase activity(GO:0004649)
0.2 1.4 GO:0019809 spermidine binding(GO:0019809)
0.2 1.6 GO:0004530 deoxyribonuclease I activity(GO:0004530)
0.2 0.8 GO:0046977 peptide antigen-transporting ATPase activity(GO:0015433) peptide-transporting ATPase activity(GO:0015440) TAP binding(GO:0046977)
0.2 0.6 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.2 0.8 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.1 0.6 GO:0005463 UDP-glucuronic acid transmembrane transporter activity(GO:0005461) UDP-N-acetylgalactosamine transmembrane transporter activity(GO:0005463)
0.1 2.6 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 0.9 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.1 1.6 GO:0019238 cyclohydrolase activity(GO:0019238)
0.1 0.6 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.1 0.4 GO:0016436 rRNA (uridine) methyltransferase activity(GO:0016436)
0.1 0.4 GO:0005132 type I interferon receptor binding(GO:0005132)
0.1 0.7 GO:1900750 oligopeptide binding(GO:1900750)
0.1 0.9 GO:0000048 peptidyltransferase activity(GO:0000048) glutathione hydrolase activity(GO:0036374)
0.1 0.8 GO:0015232 heme transporter activity(GO:0015232)
0.1 0.4 GO:0008488 gamma-glutamyl carboxylase activity(GO:0008488)
0.1 0.5 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.1 0.4 GO:0052851 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.1 0.5 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.1 1.3 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 0.7 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.1 2.0 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 0.5 GO:0035613 RNA stem-loop binding(GO:0035613)
0.1 0.2 GO:0004161 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.1 0.4 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.1 0.1 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.1 1.0 GO:0045159 myosin II binding(GO:0045159)
0.1 0.6 GO:0030332 cyclin binding(GO:0030332)
0.1 0.4 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.1 0.3 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.1 0.7 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.1 2.7 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.4 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.3 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.0 0.9 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.9 GO:0019894 kinesin binding(GO:0019894)
0.0 0.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.4 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
0.0 1.7 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 0.1 GO:0033897 ribonuclease T2 activity(GO:0033897)
0.0 0.1 GO:0047760 medium-chain fatty acid-CoA ligase activity(GO:0031956) butyrate-CoA ligase activity(GO:0047760)
0.0 0.4 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor(GO:0050664)
0.0 1.1 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 1.0 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 1.1 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.9 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.2 GO:0035197 siRNA binding(GO:0035197)
0.0 0.2 GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980)
0.0 1.6 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 1.1 GO:0035064 methylated histone binding(GO:0035064)
0.0 1.1 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.7 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.4 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.9 GO:0016917 GABA-A receptor activity(GO:0004890) GABA receptor activity(GO:0016917)
0.0 0.2 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.0 0.3 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.9 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 2.6 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.1 GO:0004061 arylformamidase activity(GO:0004061)
0.0 0.2 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.3 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.1 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763)
0.0 0.8 GO:0016307 phosphatidylinositol phosphate kinase activity(GO:0016307)
0.0 1.2 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.7 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.7 GO:0003823 antigen binding(GO:0003823)
0.0 0.9 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 1.0 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 0.1 GO:0035014 phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.0 0.6 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.5 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.3 GO:0010484 H3 histone acetyltransferase activity(GO:0010484) histone acetyltransferase activity (H3-K23 specific)(GO:0043994)
0.0 0.4 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.3 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.0 0.4 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.2 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.0 4.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 2.8 GO:0060090 binding, bridging(GO:0060090)
0.0 0.1 GO:0003983 UTP:glucose-1-phosphate uridylyltransferase activity(GO:0003983) UTP-monosaccharide-1-phosphate uridylyltransferase activity(GO:0051748)
0.0 0.5 GO:0004438 phosphatidylinositol-3-phosphatase activity(GO:0004438)
0.0 1.0 GO:0005254 chloride channel activity(GO:0005254)
0.0 0.2 GO:0005165 nerve growth factor receptor binding(GO:0005163) neurotrophin receptor binding(GO:0005165)
0.0 0.5 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.0 0.2 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.2 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.2 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.6 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.0 GO:0004478 methionine adenosyltransferase activity(GO:0004478)
0.0 0.6 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.3 GO:0004697 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698) calcium-dependent protein serine/threonine kinase activity(GO:0009931) calcium-dependent protein kinase activity(GO:0010857)
0.0 0.5 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 4.3 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 0.2 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 1.8 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.3 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.0 0.5 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.6 GO:0030215 semaphorin receptor binding(GO:0030215)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.7 PID EPHB FWD PATHWAY EPHB forward signaling
0.1 0.4 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 2.0 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 0.3 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.9 PID ARF 3PATHWAY Arf1 pathway
0.0 1.4 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 0.7 PID CD40 PATHWAY CD40/CD40L signaling
0.0 0.4 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.4 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.5 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 0.9 PID P75 NTR PATHWAY p75(NTR)-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.2 2.0 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 0.7 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 1.9 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.1 1.4 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.1 1.5 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 2.3 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 0.9 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.1 0.5 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.1 2.9 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.1 0.7 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 0.9 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.1 0.4 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.4 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.7 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.3 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.4 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.4 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.4 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
0.0 2.0 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.0 0.7 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.0 0.2 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.5 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.0 0.6 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.4 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.3 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.4 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.3 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.5 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.0 0.2 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.5 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 1.1 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.2 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.2 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 0.2 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS Genes involved in CREB phosphorylation through the activation of Ras