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PRJEB1986: zebrafish developmental stages transcriptome

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Results for isl2a+isl2b

Z-value: 0.49

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Transcription factors associated with isl2a+isl2b

Gene Symbol Gene ID Gene Info
isl2a
ENSDARG00000003971 ISL LIM homeobox 2a
isl2b
ENSDARG00000053499 ISL LIM homeobox 2b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
isl2adr11_v1_chr25_-_32751982_32751982-0.652.7e-03Click!
isl2bdr11_v1_chr7_+_29992889_29992889-0.253.0e-01Click!

Activity profile of isl2a+isl2b motif

Sorted Z-values of isl2a+isl2b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_24002503 1.95 ENSDART00000164702
chia.2
chitinase, acidic.2
chr11_+_24001993 1.75 ENSDART00000168215
chia.2
chitinase, acidic.2
chr19_-_5125663 1.74 ENSDART00000005547
ENSDART00000132642
gnb3b
guanine nucleotide binding protein (G protein), beta polypeptide 3b
chr6_-_12588044 1.54 ENSDART00000047896
slc15a1b
solute carrier family 15 (oligopeptide transporter), member 1b
chr9_+_2574122 1.53 ENSDART00000166326
ENSDART00000191822
CIR1
si:ch73-167c12.2
chr2_-_293793 1.41 ENSDART00000082091
si:ch73-40a17.3
si:ch73-40a17.3
chr2_-_293036 1.29 ENSDART00000171629
si:ch73-40a17.3
si:ch73-40a17.3
chr16_-_28658341 1.08 ENSDART00000148456
abcb4
ATP-binding cassette, sub-family B (MDR/TAP), member 4
chr6_+_54538948 1.07 ENSDART00000149270
tulp1b
tubby like protein 1b
chr21_+_11385031 1.01 ENSDART00000040598
cel.2
carboxyl ester lipase, tandem duplicate 2
chr10_-_7756865 0.99 ENSDART00000114373
ENSDART00000125407
ENSDART00000016317
loxa
lysyl oxidase a
chr12_-_4781801 0.92 ENSDART00000167490
ENSDART00000121718
mapta
microtubule-associated protein tau a
chr23_-_3511630 0.92 ENSDART00000019667
rnf114
ring finger protein 114
chr6_+_39905021 0.85 ENSDART00000064904
endou
endonuclease, polyU-specific
chr17_-_200316 0.84 ENSDART00000190561
CABZ01083778.1

chr1_-_9641845 0.82 ENSDART00000121490
ENSDART00000159411
ugt5b2
ugt5b3
UDP glucuronosyltransferase 5 family, polypeptide B2
UDP glucuronosyltransferase 5 family, polypeptide B3
chr6_+_9175886 0.82 ENSDART00000165333
si:ch211-207l14.1
si:ch211-207l14.1
chr5_-_41494831 0.78 ENSDART00000051081
eef2l2
eukaryotic translation elongation factor 2, like 2
chr12_+_16168342 0.77 ENSDART00000079326
ENSDART00000170024
lrp2b
low density lipoprotein receptor-related protein 2b
chr3_-_59297532 0.70 ENSDART00000187991
CABZ01053748.1

chr14_-_4682114 0.69 ENSDART00000014454
gabra4
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4
chr17_+_16564921 0.67 ENSDART00000151904
foxn3
forkhead box N3
chr13_-_49666615 0.66 ENSDART00000148083
tomm20a
translocase of outer mitochondrial membrane 20
chr7_+_24573721 0.63 ENSDART00000173938
ENSDART00000173681
si:dkeyp-75h12.7
si:dkeyp-75h12.7
chr25_+_3994823 0.60 ENSDART00000154020
eps8l2
EPS8 like 2
chr5_+_69747417 0.58 ENSDART00000153717
si:ch211-275j6.5
si:ch211-275j6.5
chr9_-_36924388 0.56 ENSDART00000059756
ralba
v-ral simian leukemia viral oncogene homolog Ba (ras related)
chr7_+_60079302 0.55 ENSDART00000051524
etnppl
ethanolamine-phosphate phospho-lyase
chr1_-_50859053 0.55 ENSDART00000132779
ENSDART00000137648
si:dkeyp-123h10.2
si:dkeyp-123h10.2
chr21_-_20939488 0.54 ENSDART00000039043
rgs7bpb
regulator of G protein signaling 7 binding protein b
chr8_+_52637507 0.54 ENSDART00000163830
si:dkey-90l8.3
si:dkey-90l8.3
chr11_-_1400507 0.54 ENSDART00000173029
ENSDART00000172953
ENSDART00000111140
rpl29
ribosomal protein L29
chr25_-_27621268 0.53 ENSDART00000146205
ENSDART00000073511
hyal6
hyaluronoglucosaminidase 6
chr8_+_1651821 0.53 ENSDART00000060865
ENSDART00000186304
rasal1b
RAS protein activator like 1b (GAP1 like)
chr18_+_3579829 0.52 ENSDART00000158763
ENSDART00000182850
ENSDART00000162754
ENSDART00000178789
ENSDART00000172656
lrch3
leucine-rich repeats and calponin homology (CH) domain containing 3
chr18_+_924949 0.52 ENSDART00000170888
ENSDART00000193163
pkma
pyruvate kinase M1/2a
chr12_+_24342303 0.51 ENSDART00000111239
nrxn1a
neurexin 1a
chr14_-_2206476 0.50 ENSDART00000081870
pcdh2ab6
protocadherin 2 alpha b 6
chr7_+_22657566 0.49 ENSDART00000141048
ponzr5
plac8 onzin related protein 5
chr23_-_18024543 0.49 ENSDART00000139695
pm20d1.1
peptidase M20 domain containing 1, tandem duplicate 1
chr21_-_35325466 0.48 ENSDART00000134780
ENSDART00000145930
ENSDART00000076715
ENSDART00000065341
ENSDART00000162189
ublcp1
ubiquitin-like domain containing CTD phosphatase 1
chr21_+_45841731 0.47 ENSDART00000038657
faxdc2
fatty acid hydroxylase domain containing 2
chr20_-_5291012 0.47 ENSDART00000122892
cyp46a1.3
cytochrome P450, family 46, subfamily A, polypeptide 1, tandem duplicate 3
chr22_-_10470663 0.43 ENSDART00000143352
omd
osteomodulin
chr21_-_44081540 0.43 ENSDART00000130833
FO704810.1

chr3_-_25268751 0.42 ENSDART00000139423
mgat3a
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase a
chr2_+_47249179 0.42 ENSDART00000144438
si:ch211-284d12.3
si:ch211-284d12.3
chr2_-_22927958 0.41 ENSDART00000141621
myo7bb
myosin VIIBb
chr25_+_35212919 0.41 ENSDART00000180127
ano5a
anoctamin 5a
chr5_+_22791686 0.40 ENSDART00000014806
npas2
neuronal PAS domain protein 2
chr3_-_13068189 0.40 ENSDART00000167180
prkar1b
protein kinase, cAMP-dependent, regulatory, type I, beta
chr7_-_71829649 0.40 ENSDART00000160449
cacnb2a
calcium channel, voltage-dependent, beta 2a
chr12_+_35203091 0.40 ENSDART00000153022
ndst2b
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2b
chr4_-_2219705 0.39 ENSDART00000131046
si:ch73-278m9.1
si:ch73-278m9.1
chr4_-_1801519 0.39 ENSDART00000188604
ENSDART00000135749
nudt4b
nudix (nucleoside diphosphate linked moiety X)-type motif 4b
chr12_-_6880694 0.38 ENSDART00000171846
pcdh15b
protocadherin-related 15b
chr11_+_30663300 0.37 ENSDART00000161662
ttbk1a
tau tubulin kinase 1a
chr20_+_32552912 0.36 ENSDART00000009691
scml4
Scm polycomb group protein like 4
chr22_-_7168571 0.35 ENSDART00000165549
asic1b
acid-sensing (proton-gated) ion channel 1b
chr5_-_19861766 0.35 ENSDART00000088904
gltpa
glycolipid transfer protein a
chr24_-_6897884 0.34 ENSDART00000080766
dpp6a
dipeptidyl-peptidase 6a
chr10_-_2524297 0.34 ENSDART00000192475
CU856539.1

chr25_-_9805269 0.34 ENSDART00000192048
lrrc4c
leucine rich repeat containing 4C
chr22_-_17844117 0.34 ENSDART00000159363
BX908731.1

chr3_+_7808459 0.33 ENSDART00000162374
hook2
hook microtubule-tethering protein 2
chr22_-_14739491 0.32 ENSDART00000133385
lrp1ba
low density lipoprotein receptor-related protein 1Ba
chr17_-_2834764 0.32 ENSDART00000024027
bdkrb1
bradykinin receptor B1
chr20_-_47188966 0.31 ENSDART00000152965
si:dkeyp-104f11.9
si:dkeyp-104f11.9
chr23_-_36724575 0.31 ENSDART00000159560
agap2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr7_-_2047639 0.30 ENSDART00000173892
si:cabz01007794.1
si:cabz01007794.1
chr12_+_10062953 0.30 ENSDART00000148689
slc4a1b
solute carrier family 4 (anion exchanger), member 1b (Diego blood group)
chr7_-_66868543 0.30 ENSDART00000149680
ampd3a
adenosine monophosphate deaminase 3a
chr10_-_43404027 0.30 ENSDART00000086227
edil3b
EGF-like repeats and discoidin I-like domains 3b
chr24_-_6898302 0.29 ENSDART00000158646
dpp6a
dipeptidyl-peptidase 6a
chr12_+_18681477 0.29 ENSDART00000127981
ENSDART00000143979
rgs9b
regulator of G protein signaling 9b
chr2_+_49232559 0.29 ENSDART00000154285
ENSDART00000175147
sema6ba
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Ba
chr20_+_36234335 0.29 ENSDART00000193484
ENSDART00000181664
cnih3
cornichon family AMPA receptor auxiliary protein 3
chr7_-_7692992 0.28 ENSDART00000192619
aadat
aminoadipate aminotransferase
chr9_+_54039006 0.28 ENSDART00000112441
tlr7
toll-like receptor 7
chr25_+_13406069 0.28 ENSDART00000010495
znrf1
zinc and ring finger 1
chr15_+_46356879 0.28 ENSDART00000154388
wu:fb18f06
wu:fb18f06
chr12_-_4532066 0.28 ENSDART00000092687
trpm4b.2
transient receptor potential cation channel, subfamily M, member 4b, transient receptor potential cation channel, subfamily M, member 4b, tandem duplicate 2
chr19_-_47323267 0.28 ENSDART00000190077
CU138512.1

chr19_+_9186175 0.27 ENSDART00000039325
hcn3
hyperpolarization activated cyclic nucleotide-gated potassium channel 3
chr20_+_66857 0.27 ENSDART00000114999
lrfn2b
leucine rich repeat and fibronectin type III domain containing 2b
chr9_+_32069989 0.26 ENSDART00000139540
si:dkey-83m22.7
si:dkey-83m22.7
chr14_+_21722235 0.26 ENSDART00000183667
stx3a
syntaxin 3A
chr15_-_46779934 0.25 ENSDART00000085136
clcn2c
chloride channel 2c
chr1_-_17803614 0.25 ENSDART00000138475
sorbs2a
sorbin and SH3 domain containing 2a
chr6_-_52788213 0.25 ENSDART00000179880
rbpjl
recombination signal binding protein for immunoglobulin kappa J region-like
chr18_-_8398972 0.24 ENSDART00000136512
BEND7
si:ch211-220f12.4
chr19_-_5769728 0.24 ENSDART00000133106
si:ch211-264f5.6
si:ch211-264f5.6
chr15_+_9327252 0.23 ENSDART00000144381
sgcg
sarcoglycan, gamma
chr19_+_31904836 0.23 ENSDART00000162297
ENSDART00000088340
ENSDART00000151280
ENSDART00000151218
tpd52
tumor protein D52
chr11_-_45138857 0.23 ENSDART00000166501
cant1b
calcium activated nucleotidase 1b
chr1_+_55279124 0.23 ENSDART00000152660
si:ch211-286b5.6
si:ch211-286b5.6
chr14_+_36521005 0.23 ENSDART00000192286
TENM3
si:dkey-237h12.3
chr7_-_50410524 0.23 ENSDART00000083346
hypk
huntingtin interacting protein K
chr9_+_51147380 0.22 ENSDART00000003913
ifih1
interferon induced with helicase C domain 1
chr11_-_26832685 0.22 ENSDART00000153519
iqsec1b
IQ motif and Sec7 domain 1b
chr22_-_17482282 0.21 ENSDART00000105453
si:ch211-197g15.7
si:ch211-197g15.7
chr16_+_11660839 0.21 ENSDART00000193911
ENSDART00000143683
si:dkey-250k15.10
si:dkey-250k15.10
chr6_-_49510553 0.21 ENSDART00000166238
rplp2
ribosomal protein, large P2
chr17_-_40956035 0.21 ENSDART00000124715
si:dkey-16j16.4
si:dkey-16j16.4
chr13_-_2010191 0.21 ENSDART00000161021
ENSDART00000124134
gfral
GDNF family receptor alpha like
chr22_-_17482810 0.20 ENSDART00000171293
si:ch211-197g15.7
si:ch211-197g15.7
chr11_-_29737088 0.20 ENSDART00000159828
si:ch211-218g23.6
si:ch211-218g23.6
chr11_+_29856032 0.20 ENSDART00000079150
grpr
gastrin-releasing peptide receptor
chr9_-_394088 0.20 ENSDART00000169014
si:dkey-11f4.7
si:dkey-11f4.7
chr12_+_1139690 0.19 ENSDART00000160442
CABZ01072885.1

chr15_-_14552101 0.19 ENSDART00000171169
numbl
numb homolog (Drosophila)-like
chr18_+_35128685 0.19 ENSDART00000151579
si:ch211-195m9.3
si:ch211-195m9.3
chr15_+_25438714 0.18 ENSDART00000154164
aifm4
apoptosis-inducing factor, mitochondrion-associated, 4
chr16_-_17072440 0.18 ENSDART00000002493
ENSDART00000178443
tnfrsf1a
tumor necrosis factor receptor superfamily, member 1a
chr8_+_31716872 0.18 ENSDART00000161121
oxct1a
3-oxoacid CoA transferase 1a
chr13_+_38430466 0.18 ENSDART00000132691
adgrb3
adhesion G protein-coupled receptor B3
chr25_+_7671640 0.18 ENSDART00000145367
kcnj11l
potassium inwardly-rectifying channel, subfamily J, member 11, like
chr23_-_18707418 0.18 ENSDART00000144668
ENSDART00000141205
ENSDART00000016765
zgc:103759
zgc:103759
chr19_+_24872159 0.18 ENSDART00000158490
si:ch211-195b13.1
si:ch211-195b13.1
chr7_-_7692723 0.18 ENSDART00000183352
aadat
aminoadipate aminotransferase
chr1_+_51721851 0.17 ENSDART00000040397
prdx2
peroxiredoxin 2
chr17_+_15433518 0.17 ENSDART00000026180
fabp7a
fatty acid binding protein 7, brain, a
chr1_-_25966068 0.17 ENSDART00000137869
ENSDART00000134192
synpo2b
synaptopodin 2b
chr18_+_13275735 0.17 ENSDART00000148127
plcg2
phospholipase C, gamma 2
chr21_-_35534401 0.16 ENSDART00000112308
si:dkeyp-23e4.3
si:dkeyp-23e4.3
chr8_+_25913787 0.16 ENSDART00000190257
ENSDART00000062515
sema3h
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3H
chr11_+_30057762 0.16 ENSDART00000164139
nhsb
Nance-Horan syndrome b (congenital cataracts and dental anomalies)
chr3_-_22216771 0.16 ENSDART00000130546
maptb
microtubule-associated protein tau b
chr6_+_52350443 0.15 ENSDART00000151612
ENSDART00000151349
si:ch211-239j9.1
si:ch211-239j9.1
chr18_-_3473081 0.15 ENSDART00000174975
myo7aa
myosin VIIAa
chr10_-_17083180 0.14 ENSDART00000170083
fam166b
family with sequence similarity 166, member B
chr14_-_24391424 0.14 ENSDART00000113376
ENSDART00000126894
fam13b
family with sequence similarity 13, member B
chr4_-_5019113 0.14 ENSDART00000189321
ENSDART00000081990
strip2
striatin interacting protein 2
chr1_+_39482588 0.14 ENSDART00000181790
tenm3
teneurin transmembrane protein 3
chr21_-_10886709 0.14 ENSDART00000134408
si:dkey-277m11.2
si:dkey-277m11.2
chr22_-_10165446 0.12 ENSDART00000142012
rbck1
RanBP-type and C3HC4-type zinc finger containing 1
chr4_-_49582758 0.12 ENSDART00000180834
ENSDART00000187608
si:dkey-159n16.2
si:dkey-159n16.2
chr18_+_34225520 0.11 ENSDART00000126115
v2rl1
vomeronasal 2 receptor, l1
chr21_-_35419486 0.11 ENSDART00000138529
si:dkeyp-23e4.3
si:dkeyp-23e4.3
chr22_+_19552987 0.10 ENSDART00000105315
hsd11b1la
hydroxysteroid (11-beta) dehydrogenase 1-like a
chr3_+_3681116 0.10 ENSDART00000109618
art4
ADP-ribosyltransferase 4 (Dombrock blood group)
chr22_+_30137374 0.10 ENSDART00000187808
add3a
adducin 3 (gamma) a
chr12_-_9516981 0.09 ENSDART00000106285
si:ch211-207i20.3
si:ch211-207i20.3
chr13_+_646700 0.09 ENSDART00000006892
tp53bp2a
tumor protein p53 binding protein, 2a
chr10_-_2524917 0.09 ENSDART00000188642
CU856539.1

chr7_+_66822229 0.09 ENSDART00000112109
lyve1a
lymphatic vessel endothelial hyaluronic receptor 1a
chr4_-_46915962 0.09 ENSDART00000169555
si:ch211-134c10.1
si:ch211-134c10.1
chr18_+_43891051 0.09 ENSDART00000024213
cxcr5
chemokine (C-X-C motif) receptor 5
chr7_-_12821277 0.09 ENSDART00000091584
zgc:158785
zgc:158785
chr3_+_14388010 0.09 ENSDART00000171726
ENSDART00000165452
tmem56b
transmembrane protein 56b
chr21_-_2814709 0.08 ENSDART00000097664
SEMA4D
semaphorin 4D
chr16_-_45094599 0.08 ENSDART00000155479
si:rp71-77l1.1
si:rp71-77l1.1
chr2_-_1622641 0.08 ENSDART00000082143
prkacbb
protein kinase, cAMP-dependent, catalytic, beta b
chr20_+_41021054 0.08 ENSDART00000146052
man1a1
mannosidase, alpha, class 1A, member 1
chr16_+_10972733 0.08 ENSDART00000049323
pou2f2a
POU class 2 homeobox 2a
chr5_+_55225497 0.08 ENSDART00000144087
tmc2a
transmembrane channel-like 2a
chr15_+_46357080 0.08 ENSDART00000155571
ENSDART00000156541
wu:fb18f06
wu:fb18f06
chr20_+_44082532 0.08 ENSDART00000188481
BX510352.1

chr16_+_28932038 0.07 ENSDART00000149480
npr1b
natriuretic peptide receptor 1b
chr11_-_40165683 0.07 ENSDART00000186510
si:dkey-264d12.4
si:dkey-264d12.4
chr2_+_20605925 0.07 ENSDART00000191510
olfml2bb
olfactomedin-like 2Bb
chr11_+_45436703 0.07 ENSDART00000168295
ENSDART00000173293
sos1
son of sevenless homolog 1 (Drosophila)
chr22_-_34995333 0.06 ENSDART00000110900
kcnip2
Kv channel interacting protein 2
chr3_-_54846444 0.06 ENSDART00000074010
ubald1b
UBA-like domain containing 1b
chr13_-_42560662 0.06 ENSDART00000124898
CR792417.1

chr6_+_9204099 0.05 ENSDART00000150167
ENSDART00000115394
tbx19
T-box 19
chr10_+_31248036 0.05 ENSDART00000193574
robo4
roundabout, axon guidance receptor, homolog 4 (Drosophila)
chr22_-_23545307 0.05 ENSDART00000166915
crb1
crumbs family member 1, photoreceptor morphogenesis associated
chr2_+_56657804 0.05 ENSDART00000113964
POLR2E (1 of many)
RNA polymerase II subunit E
chr24_-_26310854 0.05 ENSDART00000080113
apodb
apolipoprotein Db
chr21_-_25522510 0.05 ENSDART00000162711
cnksr2b
connector enhancer of kinase suppressor of Ras 2b
chr21_-_19314618 0.04 ENSDART00000188744
gpat3
glycerol-3-phosphate acyltransferase 3
chr22_-_23545828 0.04 ENSDART00000161253
crb1
crumbs family member 1, photoreceptor morphogenesis associated
chr10_-_45210184 0.03 ENSDART00000167128
pargl
poly (ADP-ribose) glycohydrolase, like
chr3_-_19200571 0.03 ENSDART00000131503
ENSDART00000012335
rfx1a
regulatory factor X, 1a (influences HLA class II expression)
chr9_+_12896340 0.02 ENSDART00000136417
si:ch211-167j6.5
si:ch211-167j6.5
chr6_-_54486410 0.02 ENSDART00000064679
CR847944.1

chr10_-_34916208 0.02 ENSDART00000187371
ccna1
cyclin A1
chr24_+_33622769 0.02 ENSDART00000079342
dnah5l
dynein, axonemal, heavy chain 5 like
chr1_-_52210950 0.02 ENSDART00000083946
pld6
phospholipase D family, member 6
chr8_-_52229462 0.02 ENSDART00000185949
ENSDART00000051825
tcf7l1b
transcription factor 7 like 1b
chr11_-_44979281 0.02 ENSDART00000190972
ldb1b
LIM-domain binding 1b
chr18_-_48547564 0.01 ENSDART00000138607
kcnj1a.1
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 1
chr9_+_24065855 0.01 ENSDART00000161468
ENSDART00000171577
ENSDART00000172743
ENSDART00000159324
ENSDART00000079689
ENSDART00000023196
ENSDART00000101577
lrrfip1a
leucine rich repeat (in FLII) interacting protein 1a
chr24_+_12989727 0.01 ENSDART00000126842
ENSDART00000129309
flj11011l
hypothetical protein FLJ11011-like (H. sapiens)
chr9_+_1039215 0.01 ENSDART00000192186
DOCK9 (1 of many)
dedicator of cytokinesis 9
chr25_+_21833287 0.01 ENSDART00000187606
ckmt1
creatine kinase, mitochondrial 1
chr8_+_24747865 0.01 ENSDART00000078656
slc16a4
solute carrier family 16, member 4
chr1_+_55758257 0.01 ENSDART00000139312
tecrb
trans-2,3-enoyl-CoA reductase b
chr14_-_7137808 0.01 ENSDART00000054803
trpt1
tRNA phosphotransferase 1
chr20_+_22799857 0.00 ENSDART00000058527
scfd2
sec1 family domain containing 2
chr14_-_4145594 0.00 ENSDART00000077348
casp3b
caspase 3, apoptosis-related cysteine peptidase b
chr23_+_32426954 0.00 ENSDART00000192529
ENSDART00000172313
si:ch211-66i15.5
si:ch211-66i15.5

Network of associatons between targets according to the STRING database.

First level regulatory network of isl2a+isl2b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.6 GO:0006032 chitin catabolic process(GO:0006032)
0.2 1.5 GO:0006857 oligopeptide transport(GO:0006857)
0.1 0.5 GO:2000275 regulation of oxidative phosphorylation uncoupler activity(GO:2000275)
0.1 0.6 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.1 0.3 GO:0034154 toll-like receptor 7 signaling pathway(GO:0034154)
0.1 0.3 GO:0002369 T cell cytokine production(GO:0002369)
0.1 1.0 GO:0097105 presynaptic membrane organization(GO:0097090) postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105)
0.1 0.4 GO:1901909 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.1 0.2 GO:0002432 granuloma formation(GO:0002432) chronic inflammatory response(GO:0002544) regulation of granuloma formation(GO:0002631) regulation of chronic inflammatory response(GO:0002676)
0.1 1.0 GO:0018057 peptidyl-lysine oxidation(GO:0018057)
0.1 0.3 GO:0098881 exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
0.1 0.4 GO:0070207 protein homotrimerization(GO:0070207)
0.0 0.5 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.0 0.5 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.0 1.3 GO:0009636 response to toxic substance(GO:0009636)
0.0 0.2 GO:0032608 interferon-beta production(GO:0032608) regulation of interferon-beta production(GO:0032648) positive regulation of interferon-beta production(GO:0032728)
0.0 0.4 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 0.4 GO:0034394 protein localization to cell surface(GO:0034394)
0.0 0.2 GO:0016322 neuron remodeling(GO:0016322)
0.0 0.1 GO:1903385 dendrite guidance(GO:0070983) regulation of homophilic cell adhesion(GO:1903385)
0.0 0.4 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 0.7 GO:0051932 synaptic transmission, GABAergic(GO:0051932)
0.0 0.6 GO:0006415 translational termination(GO:0006415)
0.0 0.4 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.0 0.1 GO:0046952 ketone body catabolic process(GO:0046952)
0.0 0.4 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.0 0.1 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.0 1.2 GO:0061512 protein localization to cilium(GO:0061512)
0.0 0.2 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.0 0.3 GO:0032264 IMP salvage(GO:0032264)
0.0 0.6 GO:1901379 regulation of potassium ion transmembrane transport(GO:1901379)
0.0 0.5 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)
0.0 0.1 GO:0001954 positive regulation of cell-matrix adhesion(GO:0001954)
0.0 0.2 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.0 0.9 GO:0006414 translational elongation(GO:0006414)
0.0 0.4 GO:0070167 regulation of bone mineralization(GO:0030500) regulation of biomineral tissue development(GO:0070167)
0.0 0.2 GO:0016074 snoRNA metabolic process(GO:0016074)
0.0 0.3 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.4 GO:0009648 photoperiodism(GO:0009648)
0.0 0.5 GO:0016126 sterol biosynthetic process(GO:0016126)
0.0 0.1 GO:0055117 regulation of cardiac muscle contraction(GO:0055117)
0.0 0.2 GO:0030183 B cell differentiation(GO:0030183)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:1990513 CLOCK-BMAL transcription complex(GO:1990513)
0.1 0.7 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.4 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.2 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.2 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.7 GO:1902711 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 1.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.4 GO:0032420 stereocilium(GO:0032420)
0.0 0.1 GO:0071797 LUBAC complex(GO:0071797)
0.0 0.6 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.6 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.3 GO:0048787 presynaptic active zone membrane(GO:0048787)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0015462 protein-transmembrane transporting ATPase activity(GO:0015462) efflux transmembrane transporter activity(GO:0015562)
0.3 1.0 GO:0004771 sterol esterase activity(GO:0004771)
0.3 3.6 GO:0004568 chitinase activity(GO:0004568)
0.2 1.5 GO:0042936 dipeptide transporter activity(GO:0042936) dipeptide transmembrane transporter activity(GO:0071916)
0.1 0.4 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.1 1.7 GO:0031682 G-protein gamma-subunit binding(GO:0031682)
0.1 0.5 GO:0004743 pyruvate kinase activity(GO:0004743)
0.1 0.5 GO:0033781 cholesterol 24-hydroxylase activity(GO:0033781)
0.1 0.4 GO:0000298 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.1 0.4 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.1 0.5 GO:0000254 C-4 methylsterol oxidase activity(GO:0000254)
0.1 0.5 GO:0036137 kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.1 0.6 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.1 0.2 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072) phosphodiesterase decapping endonuclease activity(GO:1990174)
0.1 1.0 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 0.6 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.1 0.4 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.4 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.7 GO:0022851 benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)
0.0 0.5 GO:0004046 aminoacylase activity(GO:0004046)
0.0 0.5 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.0 0.2 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.0 0.6 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.3 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.1 GO:0008260 3-oxoacid CoA-transferase activity(GO:0008260)
0.0 0.2 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.8 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 2.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.6 GO:0019003 GDP binding(GO:0019003)
0.0 0.3 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.8 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.2 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.3 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.0 0.4 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.8 GO:0042562 hormone binding(GO:0042562)
0.0 0.7 GO:0004521 endoribonuclease activity(GO:0004521)
0.0 0.2 GO:0038191 neuropilin binding(GO:0038191)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.4 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.4 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.4 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.1 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.3 PID NETRIN PATHWAY Netrin-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.4 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.5 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.4 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.3 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.2 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.4 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.1 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.2 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 1.1 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression