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PRJEB1986: zebrafish developmental stages transcriptome

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Results for jun

Z-value: 1.00

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Transcription factors associated with jun

Gene Symbol Gene ID Gene Info
jun
ENSDARG00000043531 Jun proto-oncogene, AP-1 transcription factor subunit

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
jundr11_v1_chr20_+_15552657_155526570.923.8e-08Click!

Activity profile of jun motif

Sorted Z-values of jun motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_48359259 3.33 ENSDART00000167353
sgo1
shugoshin 1
chr5_-_20195350 2.49 ENSDART00000139675
dao.1
D-amino-acid oxidase, tandem duplicate 1
chr20_-_26531850 2.40 ENSDART00000183317
ENSDART00000131994
mthfd1l
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like
chr20_-_26532167 2.39 ENSDART00000061914
mthfd1l
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like
chr20_+_28364742 2.37 ENSDART00000103355
rhov
ras homolog family member V
chr16_+_27543893 2.27 ENSDART00000182421
si:ch211-197h24.6
si:ch211-197h24.6
chr20_-_25626198 2.24 ENSDART00000126716
paics
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr23_-_21471022 1.90 ENSDART00000104206
her4.2
hairy-related 4, tandem duplicate 2
chr11_-_24681292 1.82 ENSDART00000089601
olfml3b
olfactomedin-like 3b
chr23_+_35714574 1.50 ENSDART00000164616
tuba1c
tubulin, alpha 1c
chr12_+_25945560 1.49 ENSDART00000109799
mmrn2b
multimerin 2b
chr10_+_22771176 1.45 ENSDART00000192046
tmem88a
transmembrane protein 88 a
chr24_-_31090948 1.40 ENSDART00000176799
hccsb
holocytochrome c synthase b
chr10_+_38593645 1.38 ENSDART00000011573
mmp13a
matrix metallopeptidase 13a
chr14_-_17588345 1.35 ENSDART00000143486
selenot2
selenoprotein T, 2
chr5_-_30615901 1.34 ENSDART00000147769
si:ch211-117m20.5
si:ch211-117m20.5
chr22_+_16497670 1.32 ENSDART00000014330
ier5
immediate early response 5
chr16_-_21785261 1.30 ENSDART00000078858
si:ch73-86n18.1
si:ch73-86n18.1
chr11_+_24251141 1.30 ENSDART00000182684
pnp4a
purine nucleoside phosphorylase 4a
chr9_-_48370645 1.25 ENSDART00000140185
col28a2a
collagen, type XXVIII, alpha 2a
chr22_+_24220937 1.23 ENSDART00000165380
uchl5
ubiquitin carboxyl-terminal hydrolase L5
chr8_-_2616326 1.19 ENSDART00000027214
slc25a25a
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25a
chr16_+_23403602 1.17 ENSDART00000159848
s100w
S100 calcium binding protein W
chr3_-_26017592 1.16 ENSDART00000030890
hmox1a
heme oxygenase 1a
chr3_-_26017831 1.15 ENSDART00000179982
hmox1a
heme oxygenase 1a
chr6_-_21534301 1.11 ENSDART00000126186
psmd12
proteasome 26S subunit, non-ATPase 12
chr24_+_31361407 1.10 ENSDART00000162668
cremb
cAMP responsive element modulator b
chr19_+_37120491 1.08 ENSDART00000032341
pef1
penta-EF-hand domain containing 1
chr25_-_13408760 1.07 ENSDART00000154445
gins3
GINS complex subunit 3
chr9_+_41024973 1.05 ENSDART00000014660
ENSDART00000144467
ormdl1
ORMDL sphingolipid biosynthesis regulator 1
chr1_-_55116453 1.04 ENSDART00000142348
sertad2a
SERTA domain containing 2a
chr10_+_32050906 1.04 ENSDART00000137373
si:ch211-266i6.3
si:ch211-266i6.3
chr19_-_42573219 1.04 ENSDART00000126021
ENSDART00000133695
ENSDART00000131558
zgc:103438
zgc:103438
chr19_+_15441022 1.04 ENSDART00000098970
ENSDART00000140276
lin28a
lin-28 homolog A (C. elegans)
chr4_-_13902188 1.04 ENSDART00000032805
gxylt1b
glucoside xylosyltransferase 1b
chr6_+_44197348 1.02 ENSDART00000075486
ppp4r2b
protein phosphatase 4, regulatory subunit 2b
chr6_+_44197099 1.02 ENSDART00000124168
ppp4r2b
protein phosphatase 4, regulatory subunit 2b
chr2_-_37837472 1.02 ENSDART00000165347
mettl17
methyltransferase like 17
chr23_+_24124684 1.01 ENSDART00000144478
si:dkey-21o19.2
si:dkey-21o19.2
chr13_-_9213207 1.00 ENSDART00000139861
ENSDART00000140524
HTRA2 (1 of many)
si:dkey-33c12.11
chr5_+_44804791 1.00 ENSDART00000122288
ctsla
cathepsin La
chr4_+_16715267 1.00 ENSDART00000143849
pkp2
plakophilin 2
chr7_+_50395856 0.99 ENSDART00000032324
hddc3
HD domain containing 3
chr25_-_12824939 0.99 ENSDART00000169126
uba2
ubiquitin-like modifier activating enzyme 2
chr19_+_15443063 0.97 ENSDART00000151732
lin28a
lin-28 homolog A (C. elegans)
chr2_+_30379650 0.96 ENSDART00000129542
crispld1b
cysteine-rich secretory protein LCCL domain containing 1b
chr14_+_46216703 0.96 ENSDART00000136045
ENSDART00000142317
mgst2
microsomal glutathione S-transferase 2
chr8_+_50534948 0.96 ENSDART00000174435
PEBP4
phosphatidylethanolamine binding protein 4
chr2_+_35612621 0.95 ENSDART00000143082
si:dkey-4i23.5
si:dkey-4i23.5
chr19_-_7420867 0.94 ENSDART00000081741
rab25a
RAB25, member RAS oncogene family a
chr5_+_24089334 0.94 ENSDART00000183748
tp53
tumor protein p53
chr4_-_6809323 0.94 ENSDART00000099467
ifrd1
interferon-related developmental regulator 1
chr11_+_11267829 0.93 ENSDART00000026814
ENSDART00000173346
ENSDART00000151926
ptp4a1
protein tyrosine phosphatase type IVA, member 1
chr19_+_24488403 0.93 ENSDART00000052421
txnipa
thioredoxin interacting protein a
chr5_+_34549845 0.92 ENSDART00000139317
aif1l
allograft inflammatory factor 1-like
chr13_+_24280380 0.91 ENSDART00000184115
acta1b
actin, alpha 1b, skeletal muscle
chr5_+_44805269 0.91 ENSDART00000136965
ctsla
cathepsin La
chr7_-_28696556 0.91 ENSDART00000148822
adgrg1
adhesion G protein-coupled receptor G1
chr8_+_28695914 0.89 ENSDART00000033386
ocstamp
osteoclast stimulatory transmembrane protein
chr3_-_39648021 0.88 ENSDART00000055171
grapa
GRB2-related adaptor protein a
chr10_+_38610741 0.87 ENSDART00000126444
mmp13a
matrix metallopeptidase 13a
chr1_+_46598764 0.87 ENSDART00000053240
cab39l
calcium binding protein 39-like
chr8_-_22288004 0.87 ENSDART00000100042
si:ch211-147a11.3
si:ch211-147a11.3
chr3_-_30488063 0.85 ENSDART00000055393
ENSDART00000151367
med25
mediator complex subunit 25
chr3_-_21062706 0.85 ENSDART00000155605
ENSDART00000153686
ENSDART00000157168
ENSDART00000156614
ENSDART00000155743
ENSDART00000156275
fam57ba
family with sequence similarity 57, member Ba
chr4_+_77948970 0.84 ENSDART00000149636
pacsin2
protein kinase C and casein kinase substrate in neurons 2
chr3_+_27027781 0.84 ENSDART00000065495
emp2
epithelial membrane protein 2
chr2_-_39675829 0.83 ENSDART00000147821
spsb4a
splA/ryanodine receptor domain and SOCS box containing 4a
chr14_+_30774032 0.83 ENSDART00000139552
atl3
atlastin 3
chr14_+_30774515 0.82 ENSDART00000191666
atl3
atlastin 3
chr3_+_32118670 0.81 ENSDART00000055287
ENSDART00000111688
zgc:109934
zgc:109934
chr10_+_31222656 0.81 ENSDART00000140988
ENSDART00000143387
tmem218
transmembrane protein 218
chr7_-_22941472 0.81 ENSDART00000190334
tnfsf10l
TNF superfamily member 10, like
chr20_+_25625872 0.81 ENSDART00000078385
ppat
phosphoribosyl pyrophosphate amidotransferase
chr1_+_59088205 0.81 ENSDART00000150649
ENSDART00000100197
zgc:173915
zgc:173915
chr21_+_20901505 0.81 ENSDART00000132741
c7b
complement component 7b
chr23_+_36130883 0.80 ENSDART00000103132
hoxc4a
homeobox C4a
chr23_-_36446307 0.80 ENSDART00000136623
zgc:174906
zgc:174906
chr25_+_30196039 0.79 ENSDART00000005299
hsd17b12a
hydroxysteroid (17-beta) dehydrogenase 12a
chr19_-_27564458 0.79 ENSDART00000123155
si:dkeyp-46h3.6
si:dkeyp-46h3.6
chr21_+_8341774 0.78 ENSDART00000129749
ENSDART00000055325
ENSDART00000133804
psmb7
proteasome subunit beta 7
chr18_+_7543347 0.78 ENSDART00000103467
arf5
ADP-ribosylation factor 5
chr25_-_12824656 0.78 ENSDART00000171801
uba2
ubiquitin-like modifier activating enzyme 2
chr25_+_32474031 0.78 ENSDART00000152124
sqor
sulfide quinone oxidoreductase
chr6_-_35439406 0.77 ENSDART00000073784
rgs5a
regulator of G protein signaling 5a
chr4_+_5317483 0.76 ENSDART00000150366
si:ch211-214j24.10
si:ch211-214j24.10
chr25_+_2282265 0.76 ENSDART00000076417
cdkn1bb
cyclin-dependent kinase inhibitor 1Bb
chr9_-_2594410 0.74 ENSDART00000188306
ENSDART00000164276
sp9
sp9 transcription factor
chr10_-_210703 0.74 ENSDART00000059476
psmg1
proteasome (prosome, macropain) assembly chaperone 1
chr2_+_48288461 0.73 ENSDART00000141495
hes6
hes family bHLH transcription factor 6
chr8_-_30204650 0.72 ENSDART00000133209
zgc:162939
zgc:162939
chr21_-_21178410 0.72 ENSDART00000185277
ENSDART00000141341
ENSDART00000145872
ENSDART00000079678
ftsj1
FtsJ RNA methyltransferase homolog 1
chr5_+_44805028 0.72 ENSDART00000141198
ctsla
cathepsin La
chr19_+_48019070 0.71 ENSDART00000158269
UBE2M
si:ch1073-205c8.3
chr6_-_43449013 0.71 ENSDART00000122423
eevs
2-epi-5-epi-valiolone synthase
chr7_+_69019851 0.70 ENSDART00000162891
CABZ01057488.1

chr10_+_16225117 0.69 ENSDART00000169885
slc12a2
solute carrier family 12 (sodium/potassium/chloride transporter), member 2
chr2_+_17524278 0.69 ENSDART00000165633
pimr196
Pim proto-oncogene, serine/threonine kinase, related 196
chr19_+_48018802 0.68 ENSDART00000161339
ENSDART00000166978
UBE2M
si:ch1073-205c8.3
chr25_+_14697247 0.68 ENSDART00000180747
mpped2
metallophosphoesterase domain containing 2b
chr12_-_27212596 0.68 ENSDART00000153101
psme3
proteasome activator subunit 3
chr1_-_58913813 0.67 ENSDART00000056494
zgc:171687
zgc:171687
chr1_+_57041549 0.67 ENSDART00000152198
si:ch211-1f22.16
si:ch211-1f22.16
chr25_+_29474583 0.67 ENSDART00000191189
il17rel
interleukin 17 receptor E-like
chr8_-_25338709 0.67 ENSDART00000131616
atp5pb
ATP synthase peripheral stalk-membrane subunit b
chr8_+_4434422 0.66 ENSDART00000145184
srrd
SRR1 domain containing
chr7_-_35432901 0.66 ENSDART00000026712
mmp2
matrix metallopeptidase 2
chr9_+_33216945 0.66 ENSDART00000134029
si:ch211-125e6.12
si:ch211-125e6.12
chr19_-_31035155 0.66 ENSDART00000161882
bzw2
basic leucine zipper and W2 domains 2
chr7_-_44704910 0.66 ENSDART00000037850
dync1li2
dynein, cytoplasmic 1, light intermediate chain 2
chr8_-_20243389 0.66 ENSDART00000184904
acer1
alkaline ceramidase 1
chr1_+_59090972 0.65 ENSDART00000171497
mfap4
microfibril associated protein 4
chr5_+_37087583 0.65 ENSDART00000049900
tagln2
transgelin 2
chr4_-_16412084 0.65 ENSDART00000188460
dcn
decorin
chr11_+_13630107 0.65 ENSDART00000172220
si:ch211-1a19.3
si:ch211-1a19.3
chr10_+_37145007 0.65 ENSDART00000131777
cuedc1a
CUE domain containing 1a
chr1_+_14253118 0.65 ENSDART00000161996
cxcl8a
chemokine (C-X-C motif) ligand 8a
chr19_-_27570333 0.64 ENSDART00000146562
ENSDART00000179060
si:dkeyp-46h3.5
si:dkeyp-46h3.8
si:dkeyp-46h3.5
si:dkeyp-46h3.8
chr2_+_15100742 0.63 ENSDART00000027171
f3b
coagulation factor IIIb
chr7_+_22688781 0.63 ENSDART00000173509
ugt5g1
UDP glucuronosyltransferase 5 family, polypeptide G1
chr8_+_39634114 0.63 ENSDART00000144293
msi1
musashi RNA-binding protein 1
chr14_-_26436951 0.63 ENSDART00000140173
si:dkeyp-110e4.6
si:dkeyp-110e4.6
chr7_-_26262978 0.62 ENSDART00000137769
ap1s1
adaptor-related protein complex 1, sigma 1 subunit
chr1_+_41849152 0.62 ENSDART00000053685
smox
spermine oxidase
chr16_+_46410520 0.62 ENSDART00000131072
rpz2
rapunzel 2
chr3_-_30248277 0.61 ENSDART00000133516
ENSDART00000077029
emc10
ER membrane protein complex subunit 10
chr3_-_34034498 0.61 ENSDART00000151145
ighv11-2
immunoglobulin heavy variable 11-2
chr1_+_59090743 0.61 ENSDART00000100199
mfap4
microfibril associated protein 4
chr15_-_28223757 0.61 ENSDART00000110969
ENSDART00000138401
scarf1
scavenger receptor class F, member 1
chr18_-_13360106 0.61 ENSDART00000091512
cmip
c-Maf inducing protein
chr7_+_41147732 0.60 ENSDART00000185388
puf60b
poly-U binding splicing factor b
chr2_+_25378457 0.60 ENSDART00000089108
fndc3ba
fibronectin type III domain containing 3Ba
chr14_+_33882973 0.60 ENSDART00000019396
clic2
chloride intracellular channel 2
chr19_-_38539670 0.60 ENSDART00000136775
col16a1
collagen, type XVI, alpha 1
chr11_+_29790626 0.60 ENSDART00000067822
dynlt3
dynein, light chain, Tctex-type 3
chr6_-_33924883 0.60 ENSDART00000132762
ENSDART00000148142
ENSDART00000142213
akr1a1b
aldo-keto reductase family 1, member A1b (aldehyde reductase)
chr14_+_15768942 0.60 ENSDART00000158998
ergic1
endoplasmic reticulum-golgi intermediate compartment 1
chr14_-_6936731 0.59 ENSDART00000162196
clk4a
CDC-like kinase 4a
chr24_-_24797455 0.59 ENSDART00000138741
pde7a
phosphodiesterase 7A
chr20_-_42972599 0.59 ENSDART00000100751
pomcb
proopiomelanocortin b
chr1_+_59073436 0.59 ENSDART00000161642
MFAP4 (1 of many)
si:zfos-2330d3.3
chr5_-_25582721 0.58 ENSDART00000123986
anxa1a
annexin A1a
chr7_+_38680034 0.58 ENSDART00000171691
ENSDART00000007913
psmc3
proteasome 26S subunit, ATPase 3
chr21_-_21020708 0.57 ENSDART00000064032
eif4ebp1
eukaryotic translation initiation factor 4E binding protein 1
chr2_-_38080075 0.57 ENSDART00000056544
tox4a
TOX high mobility group box family member 4 a
chr20_+_35445462 0.57 ENSDART00000124497
tdrd6
tudor domain containing 6
chr23_+_28377360 0.57 ENSDART00000014983
ENSDART00000128831
ENSDART00000135178
ENSDART00000138621
zgc:153867
zgc:153867
chr16_-_45225520 0.57 ENSDART00000158855
fxyd1
FXYD domain containing ion transport regulator 1 (phospholemman)
chr25_+_10485103 0.56 ENSDART00000104576
psmd13
proteasome 26S subunit, non-ATPase 13
chr13_-_17729474 0.56 ENSDART00000013011
vdac2
voltage-dependent anion channel 2
chr3_+_46762703 0.56 ENSDART00000133283
prkcsh
protein kinase C substrate 80K-H
chr23_+_28128453 0.55 ENSDART00000182618
c1galt1a
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1a
chr25_-_11378623 0.55 ENSDART00000166586
enc2
ectodermal-neural cortex 2
chr1_+_12766351 0.55 ENSDART00000165785
pcdh10a
protocadherin 10a
chr23_+_42336084 0.55 ENSDART00000158959
ENSDART00000161812
cyp2aa7
cyp2aa8
cytochrome P450, family 2, subfamily AA, polypeptide 7
cytochrome P450, family 2, subfamily AA, polypeptide 8
chr2_-_39759059 0.55 ENSDART00000007333
slc25a36a
solute carrier family 25 (pyrimidine nucleotide carrier ), member 36a
chr16_+_42829735 0.55 ENSDART00000014956
polr3glb
polymerase (RNA) III (DNA directed) polypeptide G like b
chr11_-_22371105 0.55 ENSDART00000146873
tmem183a
transmembrane protein 183A
chr19_-_43757568 0.54 ENSDART00000058491
ppt1
palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile)
chr11_-_13126969 0.54 ENSDART00000169052
ENSDART00000190120
elovl1b
ELOVL fatty acid elongase 1b
chr20_-_43723860 0.54 ENSDART00000122051
mixl1
Mix paired-like homeobox
chr8_+_50531709 0.53 ENSDART00000193352
PEBP4
phosphatidylethanolamine binding protein 4
chr10_+_187760 0.53 ENSDART00000161007
ENSDART00000160651
ets2
v-ets avian erythroblastosis virus E26 oncogene homolog 2
chr1_-_22726233 0.53 ENSDART00000140920
prom1b
prominin 1 b
chr7_-_44963154 0.53 ENSDART00000073735
rrad
Ras-related associated with diabetes
chr5_+_42064144 0.53 ENSDART00000035235
si:ch211-202a12.4
si:ch211-202a12.4
chr8_-_18667693 0.52 ENSDART00000100516
stap2b
signal transducing adaptor family member 2b
chr4_-_28958601 0.52 ENSDART00000111294
zgc:174315
zgc:174315
chr17_+_12942021 0.52 ENSDART00000192514
nfkbiab
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b
chr1_-_5746030 0.52 ENSDART00000150863
nrp2a
neuropilin 2a
chr5_-_55623443 0.52 ENSDART00000005671
ENSDART00000176341
hnrpkl
heterogeneous nuclear ribonucleoprotein K, like
chr16_+_37876779 0.51 ENSDART00000140148
si:ch211-198c19.1
si:ch211-198c19.1
chr11_+_11267493 0.51 ENSDART00000148425
ptp4a1
protein tyrosine phosphatase type IVA, member 1
chr13_-_17723417 0.51 ENSDART00000183834
vdac2
voltage-dependent anion channel 2
chr4_-_4535189 0.50 ENSDART00000057519
zgc:194209
zgc:194209
chr2_-_37862380 0.50 ENSDART00000186005
si:ch211-284o19.8
si:ch211-284o19.8
chr6_-_18976168 0.50 ENSDART00000170039
sept9b
septin 9b
chr11_+_2416064 0.50 ENSDART00000067117
ube2v1
ubiquitin-conjugating enzyme E2 variant 1
chr19_-_32641725 0.50 ENSDART00000165006
ENSDART00000188185
hpca
hippocalcin
chr19_-_31035325 0.49 ENSDART00000147504
bzw2
basic leucine zipper and W2 domains 2
chr8_+_32406885 0.49 ENSDART00000167600
epgn
epithelial mitogen homolog (mouse)
chr25_+_7423770 0.49 ENSDART00000155458
ubap1la
ubiquitin associated protein 1-like a
chr1_+_44340124 0.49 ENSDART00000160696
CT033803.2

chr11_+_14057605 0.49 ENSDART00000166262
grin3bb
glutamate receptor, ionotropic, N-methyl-D-aspartate 3Bb
chr20_-_21672970 0.49 ENSDART00000133286
si:ch211-207i1.2
si:ch211-207i1.2
chr25_+_18583877 0.49 ENSDART00000148741
met
MET proto-oncogene, receptor tyrosine kinase
chr13_+_15800742 0.49 ENSDART00000146234
apopt1
apoptogenic 1, mitochondrial
chr9_+_33217243 0.48 ENSDART00000053061
si:ch211-125e6.12
si:ch211-125e6.12
chr1_+_58677434 0.48 ENSDART00000158488
LO017784.1

chr7_-_52963493 0.48 ENSDART00000052029
cart3
cocaine- and amphetamine-regulated transcript 3
chr1_-_22861348 0.48 ENSDART00000139412
SMIM18
si:dkey-92j12.6
chr23_+_29570386 0.48 ENSDART00000193192
lzic
leucine zipper and CTNNBIP1 domain containing
chr25_-_11026907 0.48 ENSDART00000156846
mespbb
mesoderm posterior bb
chr12_+_20587179 0.48 ENSDART00000170127
arsg
arylsulfatase G
chr9_+_29323163 0.48 ENSDART00000184908
oxgr1b
oxoglutarate (alpha-ketoglutarate) receptor 1b
chr23_-_5783421 0.48 ENSDART00000131521
ENSDART00000019455
csrp1a
cysteine and glycine-rich protein 1a
chr1_-_30762264 0.47 ENSDART00000085454
dis3
DIS3 exosome endoribonuclease and 3'-5' exoribonuclease
chr17_+_33496067 0.47 ENSDART00000184724
pth2
parathyroid hormone 2
chr8_-_22288258 0.47 ENSDART00000140978
ENSDART00000100046
si:ch211-147a11.3
si:ch211-147a11.3
chr1_+_44249616 0.47 ENSDART00000164173
si:ch211-165a10.10
si:ch211-165a10.10

Network of associatons between targets according to the STRING database.

First level regulatory network of jun

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.3 GO:0071962 mitotic sister chromatid cohesion, centromeric(GO:0071962)
0.8 2.4 GO:0071896 protein localization to adherens junction(GO:0071896)
0.8 2.3 GO:0043576 respiratory gaseous exchange(GO:0007585) regulation of respiratory gaseous exchange(GO:0043576)
0.6 2.5 GO:0055130 alanine metabolic process(GO:0006522) alanine catabolic process(GO:0006524) pyruvate family amino acid metabolic process(GO:0009078) pyruvate family amino acid catabolic process(GO:0009080) D-alanine family amino acid metabolic process(GO:0046144) D-alanine metabolic process(GO:0046436) D-alanine catabolic process(GO:0055130)
0.5 1.5 GO:0061317 negative regulation of striated muscle cell differentiation(GO:0051154) negative regulation of cardiac muscle tissue development(GO:0055026) cardiac muscle cell fate commitment(GO:0060923) canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:0061317) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901296) negative regulation of cardiocyte differentiation(GO:1905208) negative regulation of cardiac muscle cell differentiation(GO:2000726)
0.3 4.8 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.3 0.9 GO:0043525 regulation of transposition, RNA-mediated(GO:0010525) negative regulation of transposition, RNA-mediated(GO:0010526) transposition, RNA-mediated(GO:0032197) positive regulation of neuron apoptotic process(GO:0043525) positive regulation of neuron death(GO:1901216)
0.3 3.0 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.3 0.8 GO:0001977 renal system process involved in regulation of blood volume(GO:0001977) renal system process involved in regulation of systemic arterial blood pressure(GO:0003071) regulation of glomerular filtration(GO:0003093)
0.3 1.4 GO:0017003 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.3 1.1 GO:0090155 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) negative regulation of ceramide biosynthetic process(GO:1900060) regulation of membrane lipid metabolic process(GO:1905038) regulation of ceramide biosynthetic process(GO:2000303)
0.3 0.8 GO:0070221 sulfide oxidation(GO:0019418) sulfide oxidation, using sulfide:quinone oxidoreductase(GO:0070221)
0.2 1.6 GO:0016266 O-glycan processing(GO:0016266)
0.2 0.6 GO:0002631 granuloma formation(GO:0002432) chronic inflammatory response(GO:0002544) regulation of granuloma formation(GO:0002631) regulation of chronic inflammatory response(GO:0002676)
0.2 1.0 GO:0019370 leukotriene metabolic process(GO:0006691) leukotriene biosynthetic process(GO:0019370)
0.2 0.6 GO:1990519 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
0.2 2.7 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.2 1.1 GO:1902315 cell cycle DNA replication initiation(GO:1902292) nuclear cell cycle DNA replication initiation(GO:1902315) mitotic DNA replication initiation(GO:1902975)
0.2 0.9 GO:0070445 regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.1 0.7 GO:0030326 embryonic limb morphogenesis(GO:0030326)
0.1 1.0 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.1 0.7 GO:0045448 regulation of mitotic cell cycle, embryonic(GO:0009794) mitotic cell cycle, embryonic(GO:0045448)
0.1 1.1 GO:0048208 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.1 0.8 GO:1904030 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.1 0.5 GO:1901842 regulation of high voltage-gated calcium channel activity(GO:1901841) negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.1 0.7 GO:0045905 positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905)
0.1 0.8 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.1 0.6 GO:0045628 neutrophil apoptotic process(GO:0001781) regulation of T-helper 1 type immune response(GO:0002825) positive regulation of T-helper 1 type immune response(GO:0002827) negative regulation of type 2 immune response(GO:0002829) inflammatory cell apoptotic process(GO:0006925) regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of phospholipase A2 activity(GO:0032429) interleukin-2 production(GO:0032623) regulation of interleukin-2 production(GO:0032663) positive regulation of interleukin-2 production(GO:0032743) myeloid cell apoptotic process(GO:0033028) regulation of neutrophil apoptotic process(GO:0033029) positive regulation of neutrophil apoptotic process(GO:0033031) regulation of myeloid cell apoptotic process(GO:0033032) positive regulation of myeloid cell apoptotic process(GO:0033034) T-helper 1 type immune response(GO:0042088) positive regulation of CD4-positive, alpha-beta T cell differentiation(GO:0043372) T-helper 1 cell differentiation(GO:0045063) positive regulation of T-helper cell differentiation(GO:0045624) regulation of T-helper 1 cell differentiation(GO:0045625) positive regulation of T-helper 1 cell differentiation(GO:0045627) regulation of T-helper 2 cell differentiation(GO:0045628) negative regulation of T-helper 2 cell differentiation(GO:0045629) positive regulation of fatty acid biosynthetic process(GO:0045723) positive regulation of alpha-beta T cell differentiation(GO:0046638) neutrophil clearance(GO:0097350) negative regulation of phospholipase A2 activity(GO:1900138) positive regulation of CD4-positive, alpha-beta T cell activation(GO:2000516) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.1 0.6 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898) positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.1 1.4 GO:0043248 proteasome assembly(GO:0043248)
0.1 2.5 GO:0048246 macrophage chemotaxis(GO:0048246)
0.1 0.4 GO:0060547 negative regulation of necroptotic process(GO:0060546) negative regulation of necrotic cell death(GO:0060547)
0.1 0.6 GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence(GO:0045050)
0.1 1.9 GO:0048936 peripheral nervous system neuron axonogenesis(GO:0048936)
0.1 0.4 GO:0071939 vitamin A transport(GO:0071938) vitamin A import(GO:0071939)
0.1 0.8 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway(GO:2001238)
0.1 0.5 GO:0097101 blood vessel endothelial cell fate specification(GO:0097101)
0.1 0.8 GO:0044857 membrane raft assembly(GO:0001765) plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) caveola assembly(GO:0070836)
0.1 0.5 GO:0003232 bulbus arteriosus development(GO:0003232)
0.1 0.4 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.1 0.2 GO:0032816 regulation of natural killer cell activation(GO:0032814) positive regulation of natural killer cell activation(GO:0032816) TRIF-dependent toll-like receptor signaling pathway(GO:0035666)
0.1 0.5 GO:0006741 NADP biosynthetic process(GO:0006741)
0.1 0.3 GO:0033688 regulation of osteoblast proliferation(GO:0033688)
0.1 0.2 GO:1901232 regulation of convergent extension involved in axis elongation(GO:1901232) positive regulation of epiboly involved in gastrulation with mouth forming second(GO:1904088)
0.1 1.8 GO:0016925 protein sumoylation(GO:0016925)
0.1 0.5 GO:0008343 adult feeding behavior(GO:0008343)
0.1 0.2 GO:0043084 copulation(GO:0007620) regulation of epinephrine secretion(GO:0014060) positive regulation of epinephrine secretion(GO:0032812) positive regulation of catecholamine secretion(GO:0033605) penile erection(GO:0043084) epinephrine transport(GO:0048241) epinephrine secretion(GO:0048242) regulation of penile erection(GO:0060405) positive regulation of penile erection(GO:0060406) prolactin secretion(GO:0070459)
0.1 0.7 GO:0034312 diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.1 0.9 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.1 1.1 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.1 0.6 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.1 0.5 GO:2000273 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) positive regulation of receptor activity(GO:2000273)
0.1 1.8 GO:0006958 humoral immune response mediated by circulating immunoglobulin(GO:0002455) complement activation, classical pathway(GO:0006958)
0.1 2.4 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.1 0.4 GO:1902093 positive regulation of sperm motility(GO:1902093)
0.1 0.6 GO:0030719 P granule organization(GO:0030719)
0.1 0.3 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 0.6 GO:0048796 swim bladder maturation(GO:0048796) swim bladder inflation(GO:0048798)
0.0 1.3 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 0.9 GO:0097178 ruffle assembly(GO:0097178)
0.0 0.9 GO:0006446 regulation of translational initiation(GO:0006446)
0.0 0.5 GO:0021707 cerebellar granular layer development(GO:0021681) cerebellar granular layer morphogenesis(GO:0021683) cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0 0.8 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0 0.3 GO:0044783 G1 DNA damage checkpoint(GO:0044783)
0.0 0.7 GO:0035701 hematopoietic stem cell migration(GO:0035701)
0.0 0.5 GO:0002084 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.0 0.4 GO:0034205 beta-amyloid formation(GO:0034205) amyloid precursor protein catabolic process(GO:0042987)
0.0 0.2 GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447)
0.0 0.6 GO:0097324 melanocyte migration(GO:0097324)
0.0 0.2 GO:0090386 phagosome maturation involved in apoptotic cell clearance(GO:0090386) phagolysosome assembly involved in apoptotic cell clearance(GO:0090387)
0.0 0.8 GO:0060021 palate development(GO:0060021)
0.0 0.3 GO:1990511 piRNA biosynthetic process(GO:1990511)
0.0 0.5 GO:0072378 blood coagulation, fibrin clot formation(GO:0072378)
0.0 0.4 GO:0070309 lens fiber cell development(GO:0070307) lens fiber cell morphogenesis(GO:0070309)
0.0 0.3 GO:0097345 mitochondrial outer membrane permeabilization(GO:0097345)
0.0 0.4 GO:0051122 lipoxygenase pathway(GO:0019372) linoleic acid metabolic process(GO:0043651) hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.0 0.7 GO:0040023 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.0 0.3 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.0 0.5 GO:0016075 rRNA catabolic process(GO:0016075)
0.0 0.8 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.0 0.4 GO:0060416 growth hormone receptor signaling pathway(GO:0060396) response to growth hormone(GO:0060416) cellular response to growth hormone stimulus(GO:0071378)
0.0 0.5 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 0.7 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.5 GO:0019367 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.4 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.4 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.3 GO:0046887 positive regulation of hormone secretion(GO:0046887)
0.0 0.8 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.6 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.7 GO:0010508 positive regulation of autophagy(GO:0010508)
0.0 0.7 GO:2000045 regulation of G1/S transition of mitotic cell cycle(GO:2000045)
0.0 0.5 GO:0006301 postreplication repair(GO:0006301)
0.0 0.4 GO:0044872 lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
0.0 0.4 GO:0008637 apoptotic mitochondrial changes(GO:0008637)
0.0 0.6 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.0 0.5 GO:0071910 determination of liver left/right asymmetry(GO:0071910)
0.0 0.2 GO:0035284 central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.0 0.7 GO:0072310 glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.0 0.5 GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030947)
0.0 0.7 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.5 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.0 0.4 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.0 0.2 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.0 0.1 GO:0036135 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171) Schwann cell migration(GO:0036135) cardiac neuron differentiation(GO:0060945) cardiac neuron development(GO:0060959)
0.0 0.3 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.0 0.6 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.6 GO:1902036 regulation of hematopoietic stem cell differentiation(GO:1902036)
0.0 0.3 GO:0035723 interleukin-15-mediated signaling pathway(GO:0035723) response to interleukin-15(GO:0070672) cellular response to interleukin-15(GO:0071350)
0.0 1.0 GO:0007596 blood coagulation(GO:0007596)
0.0 0.1 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 0.3 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.0 0.2 GO:1903707 negative regulation of hemopoiesis(GO:1903707)
0.0 0.2 GO:0036368 cone photoresponse recovery(GO:0036368)
0.0 0.1 GO:0061588 calcium activated phospholipid scrambling(GO:0061588)
0.0 0.6 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.1 GO:0060080 inhibitory postsynaptic potential(GO:0060080)
0.0 1.6 GO:0016579 protein deubiquitination(GO:0016579)
0.0 3.5 GO:0006470 protein dephosphorylation(GO:0006470)
0.0 0.1 GO:0006868 glutamine transport(GO:0006868)
0.0 0.3 GO:0006298 mismatch repair(GO:0006298)
0.0 0.5 GO:0001706 endoderm formation(GO:0001706)
0.0 0.3 GO:0038034 signal transduction in absence of ligand(GO:0038034) extrinsic apoptotic signaling pathway in absence of ligand(GO:0097192)
0.0 0.3 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.0 0.6 GO:0002224 toll-like receptor signaling pathway(GO:0002224)
0.0 0.6 GO:0042738 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.0 0.4 GO:0030278 regulation of ossification(GO:0030278)
0.0 0.3 GO:0032355 response to estradiol(GO:0032355)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0030289 protein phosphatase 4 complex(GO:0030289)
0.4 1.8 GO:0031510 SUMO activating enzyme complex(GO:0031510)
0.3 1.1 GO:0035339 SPOTS complex(GO:0035339)
0.2 1.1 GO:0000811 GINS complex(GO:0000811)
0.2 0.6 GO:0033391 chromatoid body(GO:0033391)
0.2 0.7 GO:0008537 proteasome activator complex(GO:0008537)
0.2 1.8 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.2 0.5 GO:0005577 fibrinogen complex(GO:0005577)
0.1 0.6 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.1 0.6 GO:0017177 glucosidase II complex(GO:0017177)
0.1 2.3 GO:0046930 pore complex(GO:0046930)
0.1 0.4 GO:0070195 growth hormone receptor complex(GO:0070195)
0.1 1.1 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.1 1.2 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.1 0.4 GO:0008290 F-actin capping protein complex(GO:0008290)
0.1 1.0 GO:0014704 intercalated disc(GO:0014704)
0.1 0.8 GO:0042788 polysomal ribosome(GO:0042788)
0.1 0.5 GO:0031371 ubiquitin conjugating enzyme complex(GO:0031371)
0.1 0.5 GO:0038039 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor heterodimeric complex(GO:0038039) G-protein coupled receptor complex(GO:0097648)
0.1 0.5 GO:0071914 prominosome(GO:0071914)
0.1 0.2 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.1 0.9 GO:0005869 dynactin complex(GO:0005869)
0.1 0.6 GO:0072546 ER membrane protein complex(GO:0072546)
0.1 0.2 GO:0031511 Mis6-Sim4 complex(GO:0031511)
0.1 1.1 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.7 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.4 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.5 GO:0000177 nuclear exosome (RNase complex)(GO:0000176) cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.7 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.6 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.6 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 1.0 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 1.7 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.8 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 3.3 GO:0000776 kinetochore(GO:0000776)
0.0 0.6 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 1.1 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.5 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.9 GO:0032156 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 0.8 GO:0005839 proteasome core complex(GO:0005839)
0.0 0.3 GO:0032300 mismatch repair complex(GO:0032300)
0.0 0.3 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.2 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.4 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.3 GO:1902562 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 2.2 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.3 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.2 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 1.5 GO:0005581 collagen trimer(GO:0005581)
0.0 0.8 GO:0016592 mediator complex(GO:0016592)
0.0 4.4 GO:0005764 lysosome(GO:0005764)
0.0 0.3 GO:0097546 ciliary base(GO:0097546)
0.0 0.7 GO:0005643 nuclear pore(GO:0005643)
0.0 1.4 GO:0016324 apical plasma membrane(GO:0016324)
0.0 0.4 GO:0030139 endocytic vesicle(GO:0030139)
0.0 0.9 GO:0030117 membrane coat(GO:0030117) coated membrane(GO:0048475)
0.0 0.9 GO:0055037 recycling endosome(GO:0055037)
0.0 0.1 GO:0071782 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.0 0.2 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 1.3 GO:0005635 nuclear envelope(GO:0005635)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 4.8 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.6 2.5 GO:0003884 D-amino-acid oxidase activity(GO:0003884)
0.6 2.2 GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity(GO:0004639)
0.4 1.8 GO:0019948 SUMO activating enzyme activity(GO:0019948)
0.4 2.3 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.3 1.4 GO:0004408 holocytochrome-c synthase activity(GO:0004408)
0.3 0.8 GO:0070224 sulfide:quinone oxidoreductase activity(GO:0070224)
0.2 1.0 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.2 1.1 GO:1990756 protein binding, bridging involved in substrate recognition for ubiquitination(GO:1990756)
0.2 1.1 GO:0015288 porin activity(GO:0015288)
0.2 1.0 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.2 0.6 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
0.2 0.7 GO:0016504 peptidase activator activity(GO:0016504) endopeptidase activator activity(GO:0061133)
0.2 1.0 GO:0019215 intermediate filament binding(GO:0019215)
0.2 0.6 GO:0005153 interleukin-8 receptor binding(GO:0005153)
0.1 1.3 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.1 1.0 GO:0035252 UDP-xylosyltransferase activity(GO:0035252)
0.1 0.4 GO:0004174 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.1 2.0 GO:0070628 proteasome binding(GO:0070628)
0.1 0.6 GO:0016263 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity(GO:0016263) beta-1,3-galactosyltransferase activity(GO:0048531)
0.1 0.6 GO:0046592 polyamine oxidase activity(GO:0046592)
0.1 0.7 GO:0017040 ceramidase activity(GO:0017040)
0.1 0.4 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 0.3 GO:0003913 DNA photolyase activity(GO:0003913)
0.1 0.8 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.1 0.6 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.1 3.3 GO:0003823 antigen binding(GO:0003823)
0.1 0.4 GO:0004903 growth hormone receptor activity(GO:0004903)
0.1 0.6 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.1 0.2 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.1 0.7 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.1 0.7 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.1 0.9 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.1 0.4 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 0.2 GO:0032574 5'-3' RNA helicase activity(GO:0032574)
0.1 0.6 GO:0032977 membrane insertase activity(GO:0032977)
0.1 0.5 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 0.5 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.1 0.4 GO:0004051 arachidonate 5-lipoxygenase activity(GO:0004051)
0.1 0.2 GO:0001605 adrenomedullin receptor activity(GO:0001605) calcitonin gene-related peptide receptor activity(GO:0001635)
0.1 1.8 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 0.4 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 0.4 GO:0034632 retinol transporter activity(GO:0034632)
0.1 0.2 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1 0.4 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 0.5 GO:0016840 carbon-nitrogen lyase activity(GO:0016840)
0.0 0.3 GO:0045735 nutrient reservoir activity(GO:0045735)
0.0 0.5 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.3 GO:0031705 bombesin receptor binding(GO:0031705)
0.0 1.2 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.8 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.4 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.0 0.8 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.6 GO:0048018 receptor activator activity(GO:0030546) receptor agonist activity(GO:0048018)
0.0 0.2 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.7 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.5 GO:0031386 protein tag(GO:0031386)
0.0 0.8 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.3 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0 1.9 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.7 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.4 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.4 GO:0043028 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)
0.0 4.1 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 1.0 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.8 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.5 GO:0102336 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.6 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.8 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.5 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.6 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.4 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 1.3 GO:0044389 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.0 0.5 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.4 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 1.7 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.5 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.1 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.0 0.5 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 2.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.7 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.0 0.2 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.0 0.4 GO:0051378 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 6.9 GO:0003924 GTPase activity(GO:0003924)
0.0 1.8 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.1 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.0 0.3 GO:0030983 mismatched DNA binding(GO:0030983)
0.0 0.0 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.0 0.4 GO:0035591 signaling adaptor activity(GO:0035591)
0.0 0.5 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 0.1 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0 0.4 GO:0008483 transaminase activity(GO:0008483)
0.0 0.3 GO:0042805 actinin binding(GO:0042805)
0.0 0.8 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.0 0.6 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.6 GO:0005347 ATP transmembrane transporter activity(GO:0005347)
0.0 0.7 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.3 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.0 GO:0034416 bisphosphoglycerate phosphatase activity(GO:0034416)
0.0 0.5 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.2 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 0.9 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1 0.7 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 1.2 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.5 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 0.5 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 1.1 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 0.4 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 0.6 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.3 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.2 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.7 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.8 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 0.4 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.6 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.5 PID IL1 PATHWAY IL1-mediated signaling events
0.0 0.3 PID RAS PATHWAY Regulation of Ras family activation
0.0 0.3 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 0.5 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.5 PID CMYB PATHWAY C-MYB transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.0 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 0.7 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 0.9 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.1 1.5 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 1.0 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.1 0.8 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.1 3.0 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1 0.6 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.1 0.9 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 0.5 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.1 0.6 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.1 0.6 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 1.0 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.1 0.5 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.5 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.6 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.7 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0 0.4 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.4 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.4 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.3 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.4 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.3 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 3.8 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.2 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.7 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.2 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.1 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.2 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.4 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.2 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.3 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.8 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.3 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.7 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation