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PRJEB1986: zebrafish developmental stages transcriptome
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Results for klf15+si:ch211-117k10.3
Z-value: 0.76
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Transcription factors associated with klf15+si:ch211-117k10.3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| si:ch211-117k10.3 | dr11_v1_chr11_-_38513978_38513978 | -0.87 | 1.1e-06 | Click! |
| klf15 | dr11_v1_chr23_-_35195908_35195908 | -0.86 | 1.8e-06 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_16289826 Show fit | 2.64 |
ENSDART00000131972
|
branched chain keto acid dehydrogenase E1, beta polypeptide, like |
|
| chr5_+_22067570 Show fit | 2.37 |
ENSDART00000045574
|
shisa family member 2a |
|
| chr23_+_31245395 Show fit | 2.31 |
ENSDART00000053588
|
interleukin-1 receptor-associated kinase 1 binding protein 1 |
|
| chr14_-_9522364 Show fit | 2.24 |
ENSDART00000054689
|
atonal bHLH transcription factor 8 |
|
| chr11_-_30138299 Show fit | 1.92 |
ENSDART00000172106
|
Scm polycomb group protein like 2 |
|
| chr5_+_27525477 Show fit | 1.88 |
ENSDART00000051491
|
secreted frizzled-related protein 1a |
|
| chr21_-_43117327 Show fit | 1.81 |
ENSDART00000122352
|
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide 2 |
|
| chr7_+_19552381 Show fit | 1.72 |
ENSDART00000169060
|
si:ch211-212k18.5 |
|
| chr14_+_34495216 Show fit | 1.60 |
ENSDART00000147756
|
wingless-type MMTV integration site family, member 8a |
|
| chr7_+_1449999 Show fit | 1.59 |
ENSDART00000173864
|
si:cabz01101003.1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of klf15+si:ch211-117k10.3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.3 | GO:0007249 | I-kappaB kinase/NF-kappaB signaling(GO:0007249) |
| 0.7 | 2.2 | GO:2001014 | regulation of skeletal muscle cell differentiation(GO:2001014) |
| 0.1 | 1.9 | GO:0030513 | positive regulation of BMP signaling pathway(GO:0030513) |
| 0.1 | 1.8 | GO:0019471 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) |
| 0.5 | 1.6 | GO:0021512 | spinal cord anterior/posterior patterning(GO:0021512) cell proliferation involved in pronephros development(GO:0039015) cell proliferation involved in kidney development(GO:0072111) |
| 0.5 | 1.5 | GO:0060898 | spinal cord radial glial cell differentiation(GO:0021531) eye field cell fate commitment involved in camera-type eye formation(GO:0060898) |
| 0.2 | 1.5 | GO:0072488 | ammonium transmembrane transport(GO:0072488) |
| 0.2 | 1.5 | GO:1902624 | positive regulation of neutrophil migration(GO:1902624) |
| 0.1 | 1.5 | GO:0045580 | regulation of T cell differentiation(GO:0045580) |
| 0.0 | 1.5 | GO:0000187 | activation of MAPK activity(GO:0000187) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.2 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 1.8 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 1.7 | GO:0016342 | catenin complex(GO:0016342) |
| 0.5 | 1.6 | GO:0097189 | apoptotic body(GO:0097189) |
| 0.0 | 1.5 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.2 | 1.1 | GO:0031428 | box C/D snoRNP complex(GO:0031428) |
| 0.1 | 1.1 | GO:0035060 | brahma complex(GO:0035060) |
| 0.0 | 0.6 | GO:0031941 | filamentous actin(GO:0031941) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.4 | GO:0017147 | Wnt-protein binding(GO:0017147) |
| 0.2 | 2.6 | GO:0033691 | sialic acid binding(GO:0033691) |
| 0.2 | 1.8 | GO:0004656 | procollagen-proline 4-dioxygenase activity(GO:0004656) |
| 0.0 | 1.8 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.0 | 1.6 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.1 | 1.5 | GO:0031682 | G-protein gamma-subunit binding(GO:0031682) |
| 0.1 | 1.5 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.4 | 1.2 | GO:1902945 | metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902945) |
| 0.0 | 1.2 | GO:0001594 | trace-amine receptor activity(GO:0001594) |
| 0.2 | 0.8 | GO:0000033 | alpha-1,3-mannosyltransferase activity(GO:0000033) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 1.3 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.1 | 0.9 | ST STAT3 PATHWAY | STAT3 Pathway |
| 0.1 | 0.9 | PID S1P S1P2 PATHWAY | S1P2 pathway |
| 0.0 | 0.9 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.1 | 0.7 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 0.5 | PID PDGFRA PATHWAY | PDGFR-alpha signaling pathway |
| 0.0 | 0.2 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.9 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.0 | 0.9 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.1 | 0.8 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.0 | 0.8 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.0 | 0.8 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 0.5 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.0 | 0.4 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |