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PRJEB1986: zebrafish developmental stages transcriptome

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Results for klf3+klf8

Z-value: 0.92

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Transcription factors associated with klf3+klf8

Gene Symbol Gene ID Gene Info
klf3
ENSDARG00000015495 Kruppel-like factor 3 (basic)
klf8
ENSDARG00000060661 Kruppel-like factor 8
klf3
ENSDARG00000114143 Kruppel-like factor 3 (basic)

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
klf8dr11_v1_chr21_+_38089036_380890360.483.9e-02Click!
klf3dr11_v1_chr1_-_18615063_186150630.048.6e-01Click!

Activity profile of klf3+klf8 motif

Sorted Z-values of klf3+klf8 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_41181869 4.18 ENSDART00000002046
opn1mw1
opsin 1 (cone pigments), medium-wave-sensitive, 1
chr20_-_52902693 4.01 ENSDART00000166115
ENSDART00000161050
ctsbb
cathepsin Bb
chr19_-_677713 2.74 ENSDART00000025146
slc6a19a.1
solute carrier family 6 (neutral amino acid transporter), member 19a, tandem duplicate 1
chr6_+_41186320 2.55 ENSDART00000025241
opn1mw2
opsin 1 (cone pigments), medium-wave-sensitive, 2
chr13_-_992458 2.44 ENSDART00000114655
BFSP1
beaded filament structural protein 1
chr6_-_52757276 2.40 ENSDART00000159154
AL954861.2

chr12_-_48943467 2.29 ENSDART00000191829
CABZ01092907.1

chr13_+_681628 2.19 ENSDART00000016604
abcc2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr21_-_280769 1.96 ENSDART00000157753
plgrkt
plasminogen receptor, C-terminal lysine transmembrane protein
chr6_-_39344259 1.90 ENSDART00000104074
zgc:158846
zgc:158846
chr6_-_13022166 1.87 ENSDART00000157139
tmbim1a
transmembrane BAX inhibitor motif containing 1a
chr23_+_44665230 1.84 ENSDART00000144958
camta2
calmodulin binding transcription activator 2
chr21_+_44857293 1.71 ENSDART00000134365
ENSDART00000168217
ENSDART00000065083
fstl4
follistatin-like 4
chr5_-_24174956 1.46 ENSDART00000137631
si:ch211-137i24.10
si:ch211-137i24.10
chr25_-_207214 1.39 ENSDART00000193448
FP236318.3

chr2_-_2096055 1.38 ENSDART00000126566
slc22a23
solute carrier family 22, member 23
chr16_-_20492799 1.38 ENSDART00000014769
chn2
chimerin 2
chr23_-_45049044 1.30 ENSDART00000067630
SH3GL2 (1 of many)
SH3 domain containing GRB2 like 2, endophilin A1
chr21_+_11244068 1.21 ENSDART00000163432
arid6
AT-rich interaction domain 6
chr4_-_74109792 1.18 ENSDART00000174320
RAB21
zgc:154045
chr8_+_28065803 1.12 ENSDART00000178481
kcnd3
potassium voltage-gated channel, Shal-related subfamily, member 3
chr23_-_45439903 1.09 ENSDART00000170729
NPNT (1 of many)
nephronectin
chr15_+_47418565 1.08 ENSDART00000155709
clpb
ClpB homolog, mitochondrial AAA ATPase chaperonin
chr18_+_7309150 1.05 ENSDART00000052792
cers3b
ceramide synthase 3b
chr9_+_56194410 1.03 ENSDART00000168530
LO018176.1

chr3_-_1190132 1.01 ENSDART00000149709
smdt1a
single-pass membrane protein with aspartate-rich tail 1a
chr23_-_44233408 1.00 ENSDART00000149318
ENSDART00000085528
zgc:158659
zgc:158659
chr20_-_52928541 0.98 ENSDART00000162812
fdft1
farnesyl-diphosphate farnesyltransferase 1
chr8_-_44868020 0.97 ENSDART00000142712
cacna1fa
calcium channel, voltage-dependent, L type, alpha 1F subunit a
chr25_-_36370292 0.95 ENSDART00000152766
CR354435.1
Histone H2B 1/2
chr19_+_233143 0.95 ENSDART00000175273
syngap1a
synaptic Ras GTPase activating protein 1a
chr10_+_4875262 0.92 ENSDART00000165942
palm2
paralemmin 2
chr2_-_54639964 0.90 ENSDART00000100103
acss2l
acyl-CoA synthetase short chain family member 2 like
chr10_+_4874542 0.90 ENSDART00000101431
palm2
paralemmin 2
chr10_-_20637098 0.87 ENSDART00000080391
sprn2
shadow of prion protein 2
chr4_+_54618332 0.85 ENSDART00000171824
si:ch211-227e10.2
si:ch211-227e10.2
chr10_+_466926 0.84 ENSDART00000145220
arvcfa
ARVCF, delta catenin family member a
chr7_-_32599669 0.81 ENSDART00000173752
kcna4
potassium voltage-gated channel, shaker-related subfamily, member 4
chr1_-_49434798 0.80 ENSDART00000150842
ENSDART00000150789
ATP5MD
si:dkeyp-80c12.10
chr3_+_9332984 0.79 ENSDART00000185184
ENSDART00000183535
LO018550.2

chr24_-_38644937 0.78 ENSDART00000170194
slc6a16b
solute carrier family 6, member 16b
chr16_+_44768361 0.72 ENSDART00000036302
upk1a
uroplakin 1a
chr19_+_164013 0.72 ENSDART00000167379
carmil1
capping protein regulator and myosin 1 linker 1
chr16_-_35329803 0.71 ENSDART00000161729
ENSDART00000157700
ENSDART00000184584
ENSDART00000174713
ENSDART00000162518
ptprub
protein tyrosine phosphatase, receptor type, U, b
chr24_-_14212521 0.69 ENSDART00000130825
xkr9
XK, Kell blood group complex subunit-related family, member 9
chr16_-_23471387 0.67 ENSDART00000180899
CR533578.1

chr1_-_53407087 0.65 ENSDART00000157910
elmod2
ELMO/CED-12 domain containing 2
chr7_+_13039426 0.64 ENSDART00000171777
syt7b
synaptotagmin VIIb
chr7_-_6351021 0.61 ENSDART00000159542
zgc:112234
zgc:112234
chr7_+_35229645 0.56 ENSDART00000144327
tppp3
tubulin polymerization-promoting protein family member 3
chr5_-_69041102 0.55 ENSDART00000161561
ank1a
ankyrin 1, erythrocytic a
chr10_-_18492617 0.55 ENSDART00000179936
ENSDART00000193799
ENSDART00000193198
si:dkey-28o19.1
si:dkey-28o19.1
chr12_+_48851381 0.48 ENSDART00000187241
ENSDART00000187796
dlg5b.1
discs, large homolog 5b (Drosophila), tandem duplicate 1
chr5_-_35953472 0.47 ENSDART00000143448
rxfp2l
relaxin/insulin-like family peptide receptor 2, like
chr6_-_57655030 0.45 ENSDART00000155438
cbfa2t2
core-binding factor, runt domain, alpha subunit 2; translocated to, 2
chr5_-_29587351 0.45 ENSDART00000136446
ENSDART00000051434
entpd2a.1
ectonucleoside triphosphate diphosphohydrolase 2a, tandem duplicate 1
chr12_+_48511605 0.42 ENSDART00000168389
arhgap44
Rho GTPase activating protein 44
chr11_+_45461419 0.40 ENSDART00000173424
sos1
son of sevenless homolog 1 (Drosophila)
chr25_+_37348730 0.39 ENSDART00000156639
pamr1
peptidase domain containing associated with muscle regeneration 1
chr17_+_15559046 0.38 ENSDART00000187126
bach2a
BTB and CNC homology 1, basic leucine zipper transcription factor 2a
chr25_+_23489979 0.38 ENSDART00000158200
CU024870.1

chr25_+_16731802 0.37 ENSDART00000188715
BX004976.1

chr6_-_19665114 0.37 ENSDART00000168985
usp43a
ubiquitin specific peptidase 43a
chr4_+_37992753 0.37 ENSDART00000193890
CR759843.2

chr18_+_5549672 0.37 ENSDART00000184970
nnt2
nicotinamide nucleotide transhydrogenase 2
chr7_+_35229805 0.36 ENSDART00000173911
tppp3
tubulin polymerization-promoting protein family member 3
chr14_-_48260744 0.35 ENSDART00000183955
rxfp1
relaxin/insulin-like family peptide receptor 1
chr2_-_58900077 0.35 ENSDART00000183362
ENSDART00000190274
mau2
MAU2 sister chromatid cohesion factor
chr2_+_42872661 0.35 ENSDART00000036979
efr3a
EFR3 homolog A (S. cerevisiae)
chr23_+_9057999 0.34 ENSDART00000091899
ccm2l
cerebral cavernous malformation 2-like
chr22_+_23359369 0.34 ENSDART00000170886
dennd1b
DENN/MADD domain containing 1B
chr25_+_37435720 0.33 ENSDART00000164390
chmp1a
charged multivesicular body protein 1A
chr3_+_1179601 0.32 ENSDART00000173378
triobpb
TRIO and F-actin binding protein b
chr8_-_34762163 0.31 ENSDART00000114080
setd1bb
SET domain containing 1B, b
chr23_-_1017605 0.30 ENSDART00000138290
cdh26.1
cadherin 26, tandem duplicate 1
chr24_-_40668208 0.30 ENSDART00000171543
smyhc1
slow myosin heavy chain 1
chr4_+_50401133 0.27 ENSDART00000150644
si:dkey-156k2.7
si:dkey-156k2.7
chr6_-_19664848 0.26 ENSDART00000159749
usp43a
ubiquitin specific peptidase 43a
chr22_-_16412496 0.23 ENSDART00000137497
cts12
cathepsin 12
chr21_+_17542473 0.21 ENSDART00000005750
ENSDART00000141326
stom
stomatin
chr13_-_40238813 0.20 ENSDART00000044963
loxl4
lysyl oxidase-like 4
chr6_-_13709591 0.18 ENSDART00000151771
chpfb
chondroitin polymerizing factor b
chr3_-_32927516 0.16 ENSDART00000140117
aoc2
amine oxidase, copper containing 2
chr23_-_1017428 0.15 ENSDART00000110588
ENSDART00000183158
cdh26.1
cadherin 26, tandem duplicate 1
chr11_+_37278457 0.15 ENSDART00000188946
creld1a
cysteine-rich with EGF-like domains 1a
chr21_+_21811867 0.14 ENSDART00000185752
neu3.4
sialidase 3 (membrane sialidase), tandem duplicate 4
chr23_-_4930229 0.11 ENSDART00000189456
ngfa
nerve growth factor a (beta polypeptide)
chr22_-_3275888 0.11 ENSDART00000164743
si:zfos-943e10.1
si:zfos-943e10.1
chr22_-_8594846 0.10 ENSDART00000081690
ENSDART00000192241
si:ch73-27e22.1
si:ch73-27e22.1
chr22_+_1006573 0.10 ENSDART00000123458
pparda
peroxisome proliferator-activated receptor delta a
chr5_-_12560569 0.10 ENSDART00000133587
wsb2
WD repeat and SOCS box containing 2
chr24_-_40667800 0.08 ENSDART00000169315
smyhc1
slow myosin heavy chain 1
chr5_-_64213253 0.07 ENSDART00000171711
gpsm1a
G protein signaling modulator 1a
chr9_-_12760323 0.07 ENSDART00000146265
myo10l3
myosin X-like 3
chr19_-_24218942 0.07 ENSDART00000189198
BX547993.2

chr21_+_27448856 0.04 ENSDART00000100784
cfbl
complement factor b-like
chr2_-_17392799 0.03 ENSDART00000136470
ENSDART00000141188
st3gal3b
ST3 beta-galactoside alpha-2,3-sialyltransferase 3b
chr6_+_120181 0.03 ENSDART00000151209
ENSDART00000185930
cdkn2d
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr7_-_6356875 0.03 ENSDART00000173426
zgc:112234
zgc:112234
chr14_-_21218891 0.02 ENSDART00000158294
ppp2r2cb
protein phosphatase 2, regulatory subunit B, gamma b

Network of associatons between targets according to the STRING database.

First level regulatory network of klf3+klf8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.0 GO:0010755 regulation of plasminogen activation(GO:0010755)
0.4 1.1 GO:0097623 potassium ion export(GO:0071435) potassium ion export across plasma membrane(GO:0097623)
0.2 0.7 GO:2000812 regulation of barbed-end actin filament capping(GO:2000812)
0.2 0.9 GO:0006083 acetate metabolic process(GO:0006083) acetyl-CoA biosynthetic process from acetate(GO:0019427)
0.1 6.7 GO:0018298 protein-chromophore linkage(GO:0018298)
0.1 1.0 GO:0045338 farnesyl diphosphate metabolic process(GO:0045338)
0.1 0.3 GO:0034088 maintenance of sister chromatid cohesion(GO:0034086) maintenance of mitotic sister chromatid cohesion(GO:0034088)
0.1 1.1 GO:0034605 cellular response to heat(GO:0034605)
0.1 0.4 GO:0006740 NADPH regeneration(GO:0006740)
0.1 0.8 GO:0045762 activation of adenylate cyclase activity(GO:0007190) positive regulation of cAMP metabolic process(GO:0030816) positive regulation of cAMP biosynthetic process(GO:0030819) positive regulation of adenylate cyclase activity(GO:0045762)
0.1 0.7 GO:0070782 phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.1 1.0 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.1 0.4 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.1 1.0 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0 0.3 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 0.4 GO:0045471 response to ethanol(GO:0045471)
0.0 0.3 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.0 0.9 GO:0046785 microtubule polymerization(GO:0046785)
0.0 0.7 GO:0001757 somite specification(GO:0001757)
0.0 0.8 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 3.5 GO:0035725 sodium ion transmembrane transport(GO:0035725)
0.0 1.1 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 0.6 GO:0014059 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.0 1.7 GO:0051260 protein homooligomerization(GO:0051260)
0.0 0.3 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 0.1 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.0 0.2 GO:0018057 peptidyl-lysine oxidation(GO:0018057)
0.0 0.2 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 0.1 GO:0010887 negative regulation of cholesterol storage(GO:0010887)
0.0 1.0 GO:0070509 calcium ion import(GO:0070509)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.9 GO:0045095 keratin filament(GO:0045095)
0.1 6.7 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 1.0 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.1 1.0 GO:1990246 uniplex complex(GO:1990246)
0.0 1.9 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 0.3 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.3 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 2.2 GO:0016324 apical plasma membrane(GO:0016324)
0.0 3.9 GO:0005764 lysosome(GO:0005764)
0.0 1.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.2 1.1 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.2 0.9 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.1 6.7 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.1 0.4 GO:0008746 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.1 1.0 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
0.1 0.8 GO:0031420 potassium ion binding(GO:0030955) alkali metal ion binding(GO:0031420)
0.1 1.1 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.2 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 1.0 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 4.2 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.2 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0 3.5 GO:0015293 symporter activity(GO:0015293)
0.0 0.3 GO:0004382 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.0 2.2 GO:0042626 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626) ATPase activity, coupled to movement of substances(GO:0043492)
0.0 0.6 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 1.3 GO:0045296 cadherin binding(GO:0045296)
0.0 0.1 GO:0052796 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.0 0.2 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.8 PID RAC1 REG PATHWAY Regulation of RAC1 activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.6 REACTOME OPSINS Genes involved in Opsins
0.1 2.2 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.1 1.9 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.0 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.4 REACTOME SOS MEDIATED SIGNALLING Genes involved in SOS-mediated signalling
0.0 1.7 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases