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PRJEB1986: zebrafish developmental stages transcriptome

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Results for mbd2

Z-value: 0.99

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Transcription factors associated with mbd2

Gene Symbol Gene ID Gene Info
mbd2
ENSDARG00000075952 methyl-CpG binding domain protein 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
mbd2dr11_v1_chr5_-_1047222_10472220.831.2e-05Click!

Activity profile of mbd2 motif

Sorted Z-values of mbd2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_68562464 3.46 ENSDART00000192954
BX548011.4

chr4_-_77557279 2.96 ENSDART00000180113
AL935186.10

chr2_-_56635744 2.64 ENSDART00000167790
ENSDART00000168160
pip5k1cb
phosphatidylinositol-4-phosphate 5-kinase, type I, gamma b
chr22_-_12862415 2.00 ENSDART00000145156
ENSDART00000137280
glsa
glutaminase a
chr21_+_1143141 1.89 ENSDART00000178294
CABZ01086139.1

chr7_+_2467057 1.79 ENSDART00000154517
si:dkey-125e8.3
si:dkey-125e8.3
chr14_+_14992909 1.62 ENSDART00000182203
BX119314.1

chr9_-_21936841 1.58 ENSDART00000144843
lmo7a
LIM domain 7a
chr18_+_3579829 1.51 ENSDART00000158763
ENSDART00000182850
ENSDART00000162754
ENSDART00000178789
ENSDART00000172656
lrch3
leucine-rich repeats and calponin homology (CH) domain containing 3
chr25_+_34407529 1.48 ENSDART00000156751
OTUD7A
si:dkey-37f18.2
chr19_+_5480327 1.48 ENSDART00000148794
jupb
junction plakoglobin b
chr19_-_42045372 1.45 ENSDART00000144275
trioa
trio Rho guanine nucleotide exchange factor a
chr23_-_3681026 1.44 ENSDART00000192128
ENSDART00000040086
pacsin1a
protein kinase C and casein kinase substrate in neurons 1a
chr24_-_35699595 1.40 ENSDART00000167990
mapre2
microtubule-associated protein, RP/EB family, member 2
chr18_-_46763170 1.39 ENSDART00000171880
dner
delta/notch-like EGF repeat containing
chr15_+_11693624 1.11 ENSDART00000193630
ENSDART00000161930
strn4
striatin, calmodulin binding protein 4
chr18_-_46464501 1.11 ENSDART00000040669
sphkap
SPHK1 interactor, AKAP domain containing
chr15_+_30158652 1.11 ENSDART00000190682
nlk2
nemo-like kinase, type 2
chr19_-_27966780 1.08 ENSDART00000110016
ube2ql1
ubiquitin-conjugating enzyme E2Q family-like 1
chr12_-_287633 1.02 ENSDART00000113335
map2k4b
mitogen-activated protein kinase kinase 4b
chr8_+_8643901 1.01 ENSDART00000142076
ENSDART00000075624
usp11
ubiquitin specific peptidase 11
chr3_-_5228137 0.90 ENSDART00000137105
myh9b
myosin, heavy chain 9b, non-muscle
chr6_+_48862 0.89 ENSDART00000082954
mbd5
methyl-CpG binding domain protein 5
chr12_-_3756405 0.88 ENSDART00000150839
fam57bb
family with sequence similarity 57, member Bb
chr22_+_2680895 0.86 ENSDART00000082245
zgc:194221
zgc:194221
chr4_+_11439511 0.85 ENSDART00000150485
pcloa
piccolo presynaptic cytomatrix protein a
chr2_+_56139941 0.85 ENSDART00000164741
pgpep1
pyroglutamyl-peptidase I
chr14_+_44860335 0.85 ENSDART00000091620
ENSDART00000173043
ENSDART00000091625
atp8a1
ATPase phospholipid transporting 8A1
chr19_-_45534392 0.84 ENSDART00000163920
trps1
trichorhinophalangeal syndrome I
chr19_+_42142381 0.83 ENSDART00000129915
kcnq4
potassium voltage-gated channel, KQT-like subfamily, member 4
chr2_-_32738535 0.83 ENSDART00000135293
nrbp2a
nuclear receptor binding protein 2a
chr22_-_3564563 0.82 ENSDART00000145114
ptprsa
protein tyrosine phosphatase, receptor type, s, a
chr11_-_270210 0.81 ENSDART00000005217
ENSDART00000172779
alas1
aminolevulinate, delta-, synthase 1
chr6_+_39222598 0.80 ENSDART00000154991
b4galnt1b
beta-1,4-N-acetyl-galactosaminyl transferase 1b
chr20_+_18943406 0.80 ENSDART00000193590
mtmr9
myotubularin related protein 9
chr6_-_1874664 0.79 ENSDART00000007972
dlgap4b
discs, large (Drosophila) homolog-associated protein 4b
chr18_-_51015718 0.79 ENSDART00000190698
LO018598.1

chr8_+_54013199 0.77 ENSDART00000158497
CABZ01079663.1

chr12_+_763051 0.76 ENSDART00000152579
abcc3
ATP-binding cassette, sub-family C (CFTR/MRP), member 3
chr7_+_30867008 0.72 ENSDART00000193106
apba2b
amyloid beta (A4) precursor protein-binding, family A, member 2b
chr16_+_5678071 0.69 ENSDART00000011166
ENSDART00000134198
ENSDART00000131575
zgc:158689
zgc:158689
chr22_+_35275468 0.68 ENSDART00000189516
ENSDART00000181572
ENSDART00000165353
ENSDART00000185352
rubcn
RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein
chr19_-_27966526 0.68 ENSDART00000141896
ube2ql1
ubiquitin-conjugating enzyme E2Q family-like 1
chr22_+_35275206 0.64 ENSDART00000112234
rubcn
RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein
chr6_+_49771626 0.63 ENSDART00000134207
ctsz
cathepsin Z
chr25_+_34407740 0.61 ENSDART00000012677
OTUD7A
si:dkey-37f18.2
chr7_-_9556354 0.58 ENSDART00000127974
lrrk1
leucine-rich repeat kinase 1
chr17_-_26604549 0.57 ENSDART00000174773
fam149b1
family with sequence similarity 149, member B1
chr19_+_14352332 0.54 ENSDART00000164386
arid1ab
AT rich interactive domain 1Ab (SWI-like)
chr16_-_42238120 0.54 ENSDART00000084730
zgc:162160
zgc:162160
chr17_+_53250802 0.53 ENSDART00000143819
VASH1
vasohibin 1
chr13_-_51922290 0.52 ENSDART00000168648
srfb
serum response factor b
chr24_-_35699444 0.52 ENSDART00000166567
mapre2
microtubule-associated protein, RP/EB family, member 2
chr2_+_35854242 0.52 ENSDART00000134918
dhx9
DEAH (Asp-Glu-Ala-His) box helicase 9
chr14_-_451555 0.52 ENSDART00000190906
FAT4
FAT atypical cadherin 4
chr3_+_26081343 0.51 ENSDART00000134647
atp2a1
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
chr4_+_27018663 0.51 ENSDART00000180778
CR749777.1

chr23_+_45584223 0.49 ENSDART00000149367
si:ch73-290k24.5
si:ch73-290k24.5
chr2_+_50062165 0.48 ENSDART00000097939
ENSDART00000138214
zcchc2
zinc finger, CCHC domain containing 2
chr11_-_575786 0.48 ENSDART00000019997
mkrn2
makorin, ring finger protein, 2
chr14_+_94603 0.48 ENSDART00000162480
mcm7
minichromosome maintenance complex component 7
chr11_-_27738489 0.47 ENSDART00000181612
fam120a
family with sequence similarity 120A
chr13_-_40120252 0.46 ENSDART00000157852
crtac1b
cartilage acidic protein 1b
chr3_-_25813426 0.46 ENSDART00000039482
ntn1b
netrin 1b
chr15_-_3940671 0.45 ENSDART00000189741
mindy4b
MINDY family member 4B
chr9_+_1365747 0.45 ENSDART00000140917
ENSDART00000036605
prkra
protein kinase, interferon-inducible double stranded RNA dependent activator
chr6_-_31336317 0.44 ENSDART00000193927
dnajc6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr5_+_32009956 0.44 ENSDART00000188482
scai
suppressor of cancer cell invasion
chr1_-_65017 0.44 ENSDART00000168609
si:zfos-1011f11.2
si:zfos-1011f11.2
chr10_+_16225553 0.44 ENSDART00000129844
slc12a2
solute carrier family 12 (sodium/potassium/chloride transporter), member 2
chr14_+_743346 0.42 ENSDART00000110511
klb
klotho beta
chr22_-_5099824 0.41 ENSDART00000122341
ENSDART00000161345
zfr2
zinc finger RNA binding protein 2
chr14_+_52440161 0.41 ENSDART00000168437
b4galt1l
DP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1, like
chr8_-_41519234 0.40 ENSDART00000167283
ENSDART00000180666
golga1
golgin A1
chr21_-_12272543 0.40 ENSDART00000081510
ENSDART00000151297
celf4
CUGBP, Elav-like family member 4
chr13_-_27620815 0.39 ENSDART00000139904
kcnq5a
potassium voltage-gated channel, KQT-like subfamily, member 5a
chr14_-_41272034 0.35 ENSDART00000191709
ENSDART00000074438
cenpi
centromere protein I
chr9_+_24159725 0.35 ENSDART00000137756
hecw2a
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2a
chr17_+_6382275 0.33 ENSDART00000056324
CR628323.2

chr8_-_20230559 0.32 ENSDART00000193677
mllt1a
MLLT1, super elongation complex subunit a
chr22_+_110158 0.31 ENSDART00000143698
prkar2ab
protein kinase, cAMP-dependent, regulatory, type II, alpha, B
chr10_-_28193642 0.30 ENSDART00000019050
rps6kb1a
ribosomal protein S6 kinase b, polypeptide 1a
chr14_-_3032016 0.30 ENSDART00000183461
ENSDART00000183035
ndst1a
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1a
chr3_-_17716322 0.29 ENSDART00000192664
CABZ01018956.1

chr7_+_65272470 0.29 ENSDART00000162471
bco1
beta-carotene oxygenase 1
chr13_+_4888351 0.29 ENSDART00000145940
micu1
mitochondrial calcium uptake 1
chr16_-_27161410 0.29 ENSDART00000177503
LO017771.1

chr24_-_21404367 0.29 ENSDART00000152093
atp8a2
ATPase phospholipid transporting 8A2
chr6_+_58725653 0.29 ENSDART00000190584
igsf8
immunoglobulin superfamily, member 8
chr11_-_762721 0.29 ENSDART00000166465
syn2b
synapsin IIb
chr14_-_45967712 0.29 ENSDART00000043751
ENSDART00000141357
macrod1
MACRO domain containing 1
chr9_+_44034990 0.28 ENSDART00000162406
itga4
integrin alpha 4
chr17_-_6382392 0.28 ENSDART00000188051
ENSDART00000192560
ENSDART00000137389
ENSDART00000115389
txlnbb
taxilin beta b
chr6_-_19665114 0.27 ENSDART00000168985
usp43a
ubiquitin specific peptidase 43a
chr13_-_44782462 0.27 ENSDART00000141298
ENSDART00000099990
btbd9
BTB (POZ) domain containing 9
chr15_-_3078600 0.27 ENSDART00000172842
fndc3a
fibronectin type III domain containing 3A
chr8_+_2878756 0.26 ENSDART00000168107
crb2b
crumbs family member 2b
chr12_-_11457625 0.25 ENSDART00000012318
htra1b
HtrA serine peptidase 1b
chr1_-_64829 0.25 ENSDART00000180269
si:zfos-1011f11.2
si:zfos-1011f11.2
chr14_-_3031810 0.23 ENSDART00000090213
ndst1a
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1a
chr22_+_2111120 0.23 ENSDART00000165525
znf1144
zinc finger protein 1144
chr20_+_54738210 0.23 ENSDART00000151399
pak7
p21 protein (Cdc42/Rac)-activated kinase 7
chr11_+_575665 0.22 ENSDART00000122133
mkrn2os.1
MKRN2 opposite strand, tandem duplicate 1
chr2_-_5399437 0.22 ENSDART00000132411
si:ch1073-184j22.2
si:ch1073-184j22.2
chr17_-_50010121 0.21 ENSDART00000122747
tmem30aa
transmembrane protein 30Aa
chr6_-_19664848 0.19 ENSDART00000159749
usp43a
ubiquitin specific peptidase 43a
chr20_-_44055095 0.15 ENSDART00000125898
ENSDART00000082265
runx2b
runt-related transcription factor 2b
chr12_-_3773869 0.15 ENSDART00000092983
si:ch211-166g5.4
si:ch211-166g5.4
chr7_+_53755054 0.14 ENSDART00000181629
neo1a
neogenin 1a
chr4_+_77933084 0.14 ENSDART00000148728
pacsin2
protein kinase C and casein kinase substrate in neurons 2
chr21_+_11885404 0.14 ENSDART00000092015
dcaf12
DDB1 and CUL4 associated factor 12
chr9_+_44034790 0.14 ENSDART00000166110
ENSDART00000176954
itga4
integrin alpha 4
chr25_+_20272145 0.13 ENSDART00000109605
si:dkey-219c3.2
si:dkey-219c3.2
chr22_+_9060699 0.12 ENSDART00000133993
BX248395.1

chr1_-_22803147 0.12 ENSDART00000086867
tapt1b
transmembrane anterior posterior transformation 1b
chr13_-_1349922 0.12 ENSDART00000140970
si:ch73-52p7.1
si:ch73-52p7.1
chr14_-_1098607 0.11 ENSDART00000169090
ENSDART00000158905
FQ311908.1

chr19_+_770300 0.11 ENSDART00000062518
gstr
glutathione S-transferase rho
chr6_+_49771372 0.10 ENSDART00000063251
ctsz
cathepsin Z
chr13_-_1408775 0.10 ENSDART00000049684
bag2
BCL2 associated athanogene 2
chr5_+_457729 0.08 ENSDART00000025183
ift74
intraflagellar transport 74
chr19_-_47276297 0.08 ENSDART00000141437
sdc2
syndecan 2
chr19_+_46095210 0.07 ENSDART00000159753
stmnd1
stathmin domain containing 1
chr1_-_21204114 0.07 ENSDART00000141077
si:dkey-253i9.4
si:dkey-253i9.4
chr21_+_28728030 0.05 ENSDART00000097307
puraa
purine-rich element binding protein Aa
chr7_-_35314347 0.04 ENSDART00000005053
slc12a4
solute carrier family 12 (potassium/chloride transporter), member 4
chr4_-_24019711 0.04 ENSDART00000077926
celf2
cugbp, Elav-like family member 2
chr21_+_7332963 0.03 ENSDART00000169834
AP3B1
adaptor related protein complex 3 beta 1 subunit
chr5_-_23485161 0.02 ENSDART00000170293
ENSDART00000134069
si:dkeyp-20g2.1
si:dkeyp-20g2.3
si:dkeyp-20g2.1
si:dkeyp-20g2.3
chr5_+_393738 0.02 ENSDART00000161456
june
JunE proto-oncogene, AP-1 transcription factor subunit
chr21_-_45685063 0.02 ENSDART00000162422
sar1b
secretion associated, Ras related GTPase 1B
chr4_+_58576146 0.01 ENSDART00000164911
si:ch211-212k5.4
si:ch211-212k5.4
chr20_-_45062514 0.00 ENSDART00000183529
ENSDART00000182955
klhl29
kelch-like family member 29

Network of associatons between targets according to the STRING database.

First level regulatory network of mbd2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0014014 negative regulation of gliogenesis(GO:0014014)
0.4 1.3 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) negative regulation of lipid kinase activity(GO:0090219)
0.3 1.5 GO:0002159 desmosome assembly(GO:0002159)
0.3 2.0 GO:0006543 glutamate biosynthetic process(GO:0006537) glutamine catabolic process(GO:0006543)
0.2 0.5 GO:0021960 anterior commissure morphogenesis(GO:0021960)
0.1 0.9 GO:0070650 actin filament bundle distribution(GO:0070650)
0.1 1.2 GO:0035372 protein localization to microtubule(GO:0035372) protein localization to microtubule plus-end(GO:1904825)
0.1 0.5 GO:0031448 regulation of twitch skeletal muscle contraction(GO:0014724) regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448) negative regulation of striated muscle contraction(GO:0045988) relaxation of skeletal muscle(GO:0090076)
0.1 0.3 GO:0008344 adult locomotory behavior(GO:0008344)
0.1 0.4 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.1 0.9 GO:1904071 presynaptic active zone assembly(GO:1904071)
0.1 0.7 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.1 1.6 GO:0097320 membrane tubulation(GO:0097320)
0.1 0.8 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.1 0.8 GO:0099560 synaptic membrane adhesion(GO:0099560)
0.1 0.3 GO:0072103 renal system vasculature morphogenesis(GO:0061438) kidney vasculature morphogenesis(GO:0061439) glomerulus vasculature morphogenesis(GO:0072103) glomerular capillary formation(GO:0072104)
0.1 0.8 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.0 0.3 GO:0051561 positive regulation of mitochondrial calcium ion concentration(GO:0051561)
0.0 0.5 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 1.0 GO:0043507 activation of JUN kinase activity(GO:0007257) positive regulation of JUN kinase activity(GO:0043507)
0.0 0.8 GO:0098962 regulation of postsynaptic neurotransmitter receptor activity(GO:0098962)
0.0 0.3 GO:2000650 negative regulation of sodium ion transmembrane transporter activity(GO:2000650)
0.0 0.5 GO:1902299 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.0 0.1 GO:0045724 positive regulation of cilium assembly(GO:0045724)
0.0 1.3 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.8 GO:0010507 negative regulation of autophagy(GO:0010507)
0.0 0.3 GO:0016119 carotene metabolic process(GO:0016119) carotene catabolic process(GO:0016121) terpene metabolic process(GO:0042214) terpene catabolic process(GO:0046247)
0.0 0.1 GO:0097435 fibril organization(GO:0097435)
0.0 0.4 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.3 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.0 1.1 GO:0030901 midbrain development(GO:0030901)
0.0 0.5 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.4 GO:0034508 centromere complex assembly(GO:0034508)
0.0 2.6 GO:0046488 phosphatidylinositol metabolic process(GO:0046488)
0.0 1.7 GO:0042157 lipoprotein metabolic process(GO:0042157)
0.0 0.1 GO:0035776 intraciliary transport involved in cilium morphogenesis(GO:0035735) pronephric proximal tubule development(GO:0035776)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0010369 chromocenter(GO:0010369)
0.1 0.5 GO:0031673 H zone(GO:0031673)
0.1 0.9 GO:0098982 GABA-ergic synapse(GO:0098982)
0.1 0.5 GO:0035060 brahma complex(GO:0035060)
0.1 1.0 GO:0030057 desmosome(GO:0030057)
0.0 1.2 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.5 GO:0042555 MCM complex(GO:0042555)
0.0 0.8 GO:0098978 glutamatergic synapse(GO:0098978)
0.0 0.3 GO:1990246 uniplex complex(GO:1990246)
0.0 0.9 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0016920 pyroglutamyl-peptidase activity(GO:0016920)
0.3 0.8 GO:0016748 succinyltransferase activity(GO:0016748)
0.2 2.0 GO:0004359 glutaminase activity(GO:0004359)
0.2 1.0 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.2 1.1 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.2 1.5 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 0.4 GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.1 0.5 GO:0043140 ATP-dependent 3'-5' DNA helicase activity(GO:0043140) single-stranded DNA-dependent ATP-dependent 3'-5' DNA helicase activity(GO:1990518)
0.1 0.5 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.1 2.6 GO:0016307 phosphatidylinositol phosphate kinase activity(GO:0016307)
0.1 0.5 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.9 GO:0098882 structural constituent of presynaptic active zone(GO:0098882)
0.0 0.3 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.4 GO:0008422 beta-glucosidase activity(GO:0008422)
0.0 1.8 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 1.2 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 1.1 GO:0051018 protein kinase A binding(GO:0051018)
0.0 0.3 GO:0003834 beta-carotene 15,15'-monooxygenase activity(GO:0003834) carotenoid dioxygenase activity(GO:0010436)
0.0 1.1 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.2 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 0.5 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.7 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.5 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.0 0.7 GO:0004438 phosphatidylinositol-3-phosphatase activity(GO:0004438)
0.0 0.3 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.1 GO:0043295 glutathione binding(GO:0043295)
0.0 0.9 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.1 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 0.8 GO:0008376 acetylgalactosaminyltransferase activity(GO:0008376)
0.0 0.5 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 1.5 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 0.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.0 1.3 GO:1901981 phosphatidylinositol phosphate binding(GO:1901981)
0.0 0.1 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.3 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.4 PID RHOA PATHWAY RhoA signaling pathway
0.0 0.3 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.4 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.0 0.2 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.5 PID ATR PATHWAY ATR signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.1 0.8 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 1.4 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 1.2 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.5 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 1.6 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.0 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.4 REACTOME FGFR LIGAND BINDING AND ACTIVATION Genes involved in FGFR ligand binding and activation
0.0 0.5 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.2 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac