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PRJEB1986: zebrafish developmental stages transcriptome

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Results for nfic

Z-value: 0.64

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Transcription factors associated with nfic

Gene Symbol Gene ID Gene Info
ENSDARG00000043210 nuclear factor I/C

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nficdr11_v1_chr8_+_20624510_206245100.581.0e-02Click!

Activity profile of nfic motif

Sorted Z-values of nfic motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_49568335 2.94 ENSDART00000142957
collagen, type XVII, alpha 1a
chr10_+_44042033 2.05 ENSDART00000190006
ENSDART00000046172
crystallin, beta A4
chr4_+_74131530 1.78 ENSDART00000174125

chr23_-_45504991 1.56 ENSDART00000148761
collagen type XXIV alpha 1
chr1_+_7546259 1.52 ENSDART00000015732
myosin, light polypeptide 3, skeletal muscle
chr22_-_10487490 1.40 ENSDART00000064798
asporin (LRR class 1)
chr22_-_33679277 1.30 ENSDART00000169948

chr1_-_44434707 1.27 ENSDART00000110148
crystallin, beta A1, like 2
chr5_-_37935607 1.20 ENSDART00000141233
ENSDART00000084868
ENSDART00000125857
sodium channel, voltage-gated, type IV, beta b
chr8_-_6877390 1.19 ENSDART00000170883
ENSDART00000005321
neurofilament, light polypeptide b
chr12_+_22607761 1.17 ENSDART00000153112
si:dkey-219e21.2
chr16_+_50100420 1.15 ENSDART00000128167
nuclear receptor subfamily 1, group D, member 2a
chr3_+_31039923 1.13 ENSDART00000147706
cytochrome c oxidase subunit VIa polypeptide 2
chr5_-_68826177 1.06 ENSDART00000136605
si:ch211-283h6.4
chr25_-_4146947 1.06 ENSDART00000129268
fatty acid desaturase 2
chr8_-_14375890 1.04 ENSDART00000090306
xenotropic and polytropic retrovirus receptor 1a
chr17_-_125091 1.01 ENSDART00000158825
actin, alpha, cardiac muscle 1b
chr4_+_22365061 1.00 ENSDART00000039277
LHFPL tetraspan subfamily member 3
chr2_+_31665836 0.98 ENSDART00000135411
ENSDART00000143914
si:ch211-106h4.12
chr4_+_12292274 0.96 ENSDART00000061070
ENSDART00000150786
makorin, ring finger protein, 1
chr16_-_43025885 0.91 ENSDART00000193146
ENSDART00000157302
si:dkey-7j14.5
chr22_+_32120156 0.84 ENSDART00000149666
dedicator of cytokinesis 3
chr9_-_46382637 0.84 ENSDART00000085738
lactase
chr2_+_7818368 0.81 ENSDART00000007068
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr2_+_55982940 0.77 ENSDART00000097753
ENSDART00000097751
nicotinamide riboside kinase 2
chr3_+_57038033 0.70 ENSDART00000162930
BAH domain and coiled-coil containing 1a
chr11_+_14937904 0.70 ENSDART00000185103

chr20_-_47704973 0.70 ENSDART00000174808
transcription factor AP-2 beta
chr5_-_67629263 0.69 ENSDART00000133753
zinc finger and BTB domain containing 20
chr10_-_9115383 0.69 ENSDART00000139324
si:dkeyp-41f9.3
chr11_-_270210 0.66 ENSDART00000005217
ENSDART00000172779
aminolevulinate, delta-, synthase 1
chr7_-_29341233 0.66 ENSDART00000140938
ENSDART00000147251
transient receptor potential cation channel, subfamily M, member 1a
chr22_-_16400484 0.65 ENSDART00000135987
laminin, alpha 3
chr8_+_44623540 0.65 ENSDART00000141513
G protein-coupled receptor kinase 5 like
chr13_+_18371208 0.60 ENSDART00000138172
cell division cycle and apoptosis regulator 1
chr19_+_40379771 0.59 ENSDART00000017917
ENSDART00000110699
VPS50 EARP/GARPII complex subunit
VPS50 EARP/GARPII complex subunit
chr6_+_41186320 0.58 ENSDART00000025241
opsin 1 (cone pigments), medium-wave-sensitive, 2
chr7_+_52135791 0.56 ENSDART00000098705
cytochrome P450, family 2, subfamily X, polypeptide 12
chr18_-_85294 0.54 ENSDART00000044387
GA binding protein transcription factor, beta subunit 1
chr23_+_18944388 0.53 ENSDART00000104487
cytochrome c oxidase subunit IV isoform 2
chr10_-_40939706 0.52 ENSDART00000059795
ENSDART00000190510
bone morphogenetic protein 1b
chr14_+_20893065 0.52 ENSDART00000079452
lysozyme g-like 1
chr22_+_2143107 0.52 ENSDART00000172339
ENSDART00000161280
ENSDART00000163671
ENSDART00000172090
ENSDART00000163573
zinc finger protein 1164
chr17_+_52822422 0.51 ENSDART00000158273
ENSDART00000161414
Meis homeobox 2a
chr11_+_14284866 0.49 ENSDART00000163729
si:ch211-262i1.3
chr4_+_1283068 0.45 ENSDART00000167233
cholinergic receptor, muscarinic 2a
chr23_-_6765653 0.45 ENSDART00000192310

chr23_+_11669109 0.45 ENSDART00000091416
contactin 3a, tandem duplicate 1
chr3_-_34279109 0.43 ENSDART00000183255
trinucleotide repeat containing 6C1
chr14_+_23811808 0.42 ENSDART00000014411
potassium channel tetramerization domain containing 16a
chr1_-_28629471 0.41 ENSDART00000121758
endothelin receptor Ba
chr25_-_17395315 0.41 ENSDART00000064596
cytochrome P450, family 2, subfamily X, polypeptide 8
chr21_+_43253538 0.40 ENSDART00000179940
ENSDART00000164806
ENSDART00000147026
shroom family member 1
chr17_-_43466317 0.40 ENSDART00000155313
heat shock protein 4 like
chr24_-_31942656 0.40 ENSDART00000180308
ENSDART00000016879
complement component 1, q subcomponent-like 3a
chr3_+_57997980 0.39 ENSDART00000168477
ENSDART00000193840
pyrroline-5-carboxylate reductase 1a
chr23_+_21278948 0.38 ENSDART00000156701
ENSDART00000033970
ubiquitin protein ligase E3 component n-recognin 4
chr25_-_27564590 0.38 ENSDART00000073508
hyaluronoglucosaminidase 4
chr24_-_35707552 0.38 ENSDART00000165199
microtubule-associated protein, RP/EB family, member 2
chr23_+_11669337 0.38 ENSDART00000131355
contactin 3a, tandem duplicate 1
chr20_+_51464670 0.37 ENSDART00000150110
thrombomodulin
chr22_+_39058269 0.36 ENSDART00000113362
inositol hexakisphosphate kinase 1
chr13_-_22774491 0.36 ENSDART00000189320
si:ch211-150i13.1
chr9_-_48937240 0.35 ENSDART00000075627
ceramide synthase 6
chr17_+_5846202 0.34 ENSDART00000189713
fibronectin type III domain containing 4b
chr12_+_48511605 0.34 ENSDART00000168389
Rho GTPase activating protein 44
chr6_-_35032792 0.33 ENSDART00000168256
discoidin domain receptor tyrosine kinase 2a
chr3_-_38777553 0.33 ENSDART00000193045
zinc finger protein 281a
chr17_-_50233493 0.32 ENSDART00000172266
v-fos FBJ murine osteosarcoma viral oncogene homolog Aa
chr9_-_41323746 0.32 ENSDART00000140564
glutaminase b
chr9_-_32142311 0.32 ENSDART00000142768
ankyrin repeat domain 44
chr7_+_27898091 0.31 ENSDART00000186451
ENSDART00000173510
tubby bipartite transcription factor
chr11_-_43948885 0.30 ENSDART00000164522

chr15_+_31806303 0.30 ENSDART00000155902
furry homolog a (Drosophila)
chr9_-_48937089 0.29 ENSDART00000193442
ceramide synthase 6
chr11_-_42980535 0.28 ENSDART00000181160
ENSDART00000192064

chr20_+_25568694 0.28 ENSDART00000063107
ENSDART00000063128
cytochrome P450, family 2, subfamily P, polypeptide 7
chr3_-_37681824 0.27 ENSDART00000185858
G patch domain containing 8
chr5_+_37517800 0.27 ENSDART00000048107
Danio rerio latent transforming growth factor beta binding protein 3 (ltbp3), mRNA.
chr19_-_9786914 0.27 ENSDART00000181669
si:dkey-14o18.2
chr19_+_9786722 0.26 ENSDART00000138310
calcium channel, voltage-dependent, gamma subunit 6a
chr18_-_43880020 0.26 ENSDART00000185638
DEAD (Asp-Glu-Ala-Asp) box helicase 6
chr10_-_40939303 0.26 ENSDART00000134295
bone morphogenetic protein 1b
chr21_+_39361040 0.25 ENSDART00000085453
clustered mitochondria (cluA/CLU1) homolog b
chr4_-_17629444 0.25 ENSDART00000108814
nuclear receptor interacting protein 2
chr25_-_36248053 0.24 ENSDART00000134928
nuclear factor of activated T cells 3b
chr22_-_7129631 0.24 ENSDART00000171359
acid-sensing (proton-gated) ion channel 1b
chr8_+_9699111 0.23 ENSDART00000111853
GRIP1 associated protein 1
chr18_-_42313798 0.22 ENSDART00000098639
contactin 5
chr20_-_42100932 0.22 ENSDART00000191930
solute carrier family 35, member F1
chr18_+_19990412 0.21 ENSDART00000155054
ENSDART00000090310
protein inhibitor of activated STAT, 1b
chr12_+_30168342 0.21 ENSDART00000142756
actin binding LIM protein 1b
chr6_-_35401282 0.20 ENSDART00000127612
regulator of G protein signaling 5a
chr7_-_55675617 0.20 ENSDART00000021009
ENSDART00000188631
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr21_+_11865972 0.20 ENSDART00000081676
ubiquitin associated protein 1
chr12_+_13405445 0.19 ENSDART00000089042
potassium voltage-gated channel, subfamily H (eag-related), member 4b
chr15_-_14469704 0.18 ENSDART00000185077
numb homolog (Drosophila)-like
chr12_+_35654749 0.17 ENSDART00000169889
ENSDART00000167873
BAI1-associated protein 2b
chr8_+_25616946 0.17 ENSDART00000133983
solute carrier family 38, member 5a
chr20_+_54333774 0.16 ENSDART00000144633
CLOCK-interacting pacemaker b
chr5_+_22791686 0.16 ENSDART00000014806
neuronal PAS domain protein 2
chr22_-_15693085 0.15 ENSDART00000141861
si:ch1073-396h14.1
chr10_-_27566481 0.15 ENSDART00000078920
autism susceptibility candidate 2a
chr25_+_35058088 0.14 ENSDART00000156838
zgc:112234
chr21_+_38634296 0.14 ENSDART00000114467

chr2_-_8017579 0.13 ENSDART00000040209
eph receptor B3a
chr8_+_44722140 0.13 ENSDART00000163381
ELMO/CED-12 domain containing 3
chr7_+_36898622 0.12 ENSDART00000190773
TOX high mobility group box family member 3
chr7_+_38962459 0.12 ENSDART00000173851
diacylglycerol kinase, zeta a
chr7_+_31051603 0.12 ENSDART00000108721
tight junction protein 1a
chr1_+_4101741 0.12 ENSDART00000163793
SLIT and NTRK-like family, member 6
chr3_+_22905341 0.12 ENSDART00000111435
histone deacetylase 5
chr5_+_55225497 0.11 ENSDART00000144087
transmembrane channel-like 2a
chr16_+_33143503 0.11 ENSDART00000058471
ENSDART00000179385
rhomboid, veinlet-like 2 (Drosophila)
chr19_-_33996277 0.11 ENSDART00000159384
engulfment and cell motility 1 (ced-12 homolog, C. elegans)
chr21_+_10866421 0.09 ENSDART00000137858
alpha-kinase 2
chr15_-_31508221 0.09 ENSDART00000121464
si:dkey-1m11.5
chr5_+_23211938 0.09 ENSDART00000090102
two pore segment channel 1
chr7_+_73447724 0.08 ENSDART00000040786
cerebellin 6
chr11_-_24538852 0.08 ENSDART00000171004
ENSDART00000181039
pleckstrin homology domain containing, family G (with RhoGef domain) member 5a
chr12_+_30653047 0.08 ENSDART00000148562
thrombospondin 2b
chr2_+_6303639 0.07 ENSDART00000132859
otolin 1a
chr24_-_22756508 0.07 ENSDART00000035409
ENSDART00000146247
zinc finger, C2HC-type containing 1A
chr5_-_54772982 0.06 ENSDART00000122829
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr17_-_35352690 0.06 ENSDART00000016053
ring finger protein 144aa
chr5_-_32338866 0.06 ENSDART00000017956
ENSDART00000047670
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
chr16_+_21426524 0.05 ENSDART00000182869
gasdermin Eb
chr12_-_35386910 0.05 ENSDART00000153453
calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1
chr14_+_30774894 0.04 ENSDART00000023054
atlastin 3
chr25_-_17368231 0.04 ENSDART00000189291
cytochrome P450, family 2, subfamily X, polypeptide 6
chr8_-_16515127 0.04 ENSDART00000146469
ENSDART00000132681
tetratricopeptide repeat domain 39A
chr14_+_8174828 0.03 ENSDART00000167228
pleckstrin and Sec7 domain containing 2
chr21_-_22678195 0.02 ENSDART00000171231
grass carp reovirus (GCRV)-induced gene 2g
chr7_+_36898850 0.02 ENSDART00000113342
TOX high mobility group box family member 3
chr23_-_20363261 0.01 ENSDART00000054651
si:rp71-17i16.5

Network of associatons between targets according to the STRING database.

First level regulatory network of nfic

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.6 GO:0038065 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) collagen-activated signaling pathway(GO:0038065)
0.2 0.5 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.1 0.8 GO:0005513 detection of calcium ion(GO:0005513)
0.1 1.7 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 0.5 GO:0010459 cardiac conduction system development(GO:0003161) negative regulation of heart rate(GO:0010459)
0.1 0.2 GO:0099563 modification of synaptic structure(GO:0099563)
0.1 0.3 GO:1902514 calcium ion transmembrane transport via high voltage-gated calcium channel(GO:0061577) regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1902514)
0.0 0.4 GO:0006561 proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
0.0 0.2 GO:1902024 L-histidine transmembrane transport(GO:0089709) L-histidine transport(GO:1902024)
0.0 0.4 GO:1904825 protein localization to microtubule(GO:0035372) protein localization to microtubule plus-end(GO:1904825)
0.0 0.7 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.0 0.2 GO:0042754 negative regulation of circadian rhythm(GO:0042754)
0.0 0.3 GO:0006537 glutamate biosynthetic process(GO:0006537) glutamine catabolic process(GO:0006543)
0.0 1.0 GO:0006817 phosphate ion transport(GO:0006817)
0.0 0.2 GO:0070207 protein homotrimerization(GO:0070207)
0.0 0.3 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.6 GO:1902017 regulation of cilium assembly(GO:1902017)
0.0 0.4 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.0 0.8 GO:0070593 dendrite self-avoidance(GO:0070593)
0.0 1.3 GO:0032922 circadian regulation of gene expression(GO:0032922)
0.0 0.4 GO:0045974 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0 1.2 GO:0043524 negative regulation of neuron apoptotic process(GO:0043524)
0.0 3.3 GO:0002088 lens development in camera-type eye(GO:0002088)
0.0 0.2 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.7 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0 1.1 GO:0006636 unsaturated fatty acid biosynthetic process(GO:0006636)
0.0 1.1 GO:0007605 sensory perception of sound(GO:0007605)
0.0 0.2 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 0.4 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.0 0.4 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.4 GO:0050935 iridophore differentiation(GO:0050935)
0.0 2.5 GO:0008544 epidermis development(GO:0008544)
0.0 0.2 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.0 0.1 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.6 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.6 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.1 GO:0036060 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.0 0.2 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0005592 collagen type XI trimer(GO:0005592)
0.2 1.2 GO:0005883 neurofilament(GO:0005883)
0.2 0.6 GO:1990745 EARP complex(GO:1990745)
0.1 1.7 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 1.0 GO:0005869 dynactin complex(GO:0005869)
0.0 0.2 GO:0098837 postsynaptic recycling endosome(GO:0098837)
0.0 0.3 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.2 GO:1990513 CLOCK-BMAL transcription complex(GO:1990513)
0.0 0.1 GO:0098642 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.0 0.4 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.6 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.1 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.2 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.8 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.2 0.7 GO:0016748 succinyltransferase activity(GO:0016748)
0.1 0.5 GO:0003796 lysozyme activity(GO:0003796)
0.1 0.8 GO:0050262 ribosylnicotinamide kinase activity(GO:0050262)
0.1 0.4 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.1 0.8 GO:0008422 beta-glucosidase activity(GO:0008422)
0.1 1.7 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.4 GO:0004962 endothelin receptor activity(GO:0004962)
0.0 0.8 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.2 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.0 1.7 GO:0005518 collagen binding(GO:0005518)
0.0 0.6 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.5 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.6 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.0 3.3 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.3 GO:0004359 glutaminase activity(GO:0004359)
0.0 4.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.4 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.0 0.8 GO:0098632 protein binding involved in cell adhesion(GO:0098631) protein binding involved in cell-cell adhesion(GO:0098632)
0.0 0.4 GO:0000828 inositol hexakisphosphate kinase activity(GO:0000828)
0.0 0.6 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.2 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.2 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.0 0.2 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.6 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.4 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.1 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 1.4 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.6 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.4 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 1.1 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.1 0.6 REACTOME OPSINS Genes involved in Opsins
0.1 0.8 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.7 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 1.6 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.4 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.6 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.3 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.6 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization