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PRJEB1986: zebrafish developmental stages transcriptome

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Results for nkx1.2la

Z-value: 0.39

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Transcription factors associated with nkx1.2la

Gene Symbol Gene ID Gene Info
nkx1.2la
ENSDARG00000006350 NK1 transcription factor related 2-like,a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nkx1.2ladr11_v1_chr13_+_40770628_40770628-0.734.0e-04Click!

Activity profile of nkx1.2la motif

Sorted Z-values of nkx1.2la motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr25_+_29160102 1.31 ENSDART00000162854
pkmb
pyruvate kinase M1/2b
chr2_+_50608099 0.97 ENSDART00000185805
ENSDART00000111135
neurod6b
neuronal differentiation 6b
chr15_+_45640906 0.78 ENSDART00000149361
ENSDART00000149079
sagb
S-antigen; retina and pineal gland (arrestin) b
chr4_+_21129752 0.76 ENSDART00000169764
syt1a
synaptotagmin Ia
chr8_+_16025554 0.73 ENSDART00000110171
elavl4
ELAV like neuron-specific RNA binding protein 4
chr22_+_7738966 0.66 ENSDART00000147073
si:ch73-44m9.5
si:ch73-44m9.5
chr22_-_20011476 0.66 ENSDART00000093312
ENSDART00000093310
celf5a
cugbp, Elav-like family member 5a
chr2_-_38000276 0.63 ENSDART00000034790
pcp4l1
Purkinje cell protein 4 like 1
chr18_+_21408794 0.57 ENSDART00000140161
necab2
N-terminal EF-hand calcium binding protein 2
chr17_-_12385308 0.56 ENSDART00000080927
snap25b
synaptosomal-associated protein, 25b
chr14_-_14659023 0.55 ENSDART00000170355
ENSDART00000159888
ENSDART00000172241
nsdhl
NAD(P) dependent steroid dehydrogenase-like
chr5_-_51619742 0.55 ENSDART00000188537
otpb
orthopedia homeobox b
chr1_-_50859053 0.53 ENSDART00000132779
ENSDART00000137648
si:dkeyp-123h10.2
si:dkeyp-123h10.2
chr10_-_5847655 0.49 ENSDART00000192773
ankrd55
ankyrin repeat domain 55
chr23_-_20051369 0.48 ENSDART00000049836
bgnb
biglycan b
chr10_+_37137464 0.47 ENSDART00000114909
cuedc1a
CUE domain containing 1a
chr21_+_6751405 0.45 ENSDART00000037265
ENSDART00000146371
olfm1b
olfactomedin 1b
chr21_+_6751760 0.43 ENSDART00000135914
olfm1b
olfactomedin 1b
chr23_+_28582865 0.42 ENSDART00000020296
l1cama
L1 cell adhesion molecule, paralog a
chr5_+_37903790 0.41 ENSDART00000162470
tmprss4b
transmembrane protease, serine 4b
chr11_+_30057762 0.41 ENSDART00000164139
nhsb
Nance-Horan syndrome b (congenital cataracts and dental anomalies)
chr21_-_43015383 0.41 ENSDART00000065097
dpysl3
dihydropyrimidinase-like 3
chr19_-_13286722 0.40 ENSDART00000168296
ENSDART00000158330
zfpm2b
zinc finger protein, FOG family member 2b
chr23_-_15216654 0.39 ENSDART00000131649
sulf2b
sulfatase 2b
chr17_+_43032529 0.39 ENSDART00000055611
ENSDART00000154863
isca2
iron-sulfur cluster assembly 2
chr20_-_29864390 0.38 ENSDART00000161834
ENSDART00000132278
rnf144ab
ring finger protein 144ab
chr4_+_9400012 0.37 ENSDART00000191960
tmtc1
transmembrane and tetratricopeptide repeat containing 1
chr16_-_20312146 0.34 ENSDART00000134980
si:dkeyp-86h10.3
si:dkeyp-86h10.3
chr22_+_23359369 0.34 ENSDART00000170886
dennd1b
DENN/MADD domain containing 1B
chr4_+_9669717 0.33 ENSDART00000004604
si:dkey-153k10.9
si:dkey-153k10.9
chr4_-_9891874 0.33 ENSDART00000067193
adm2a
adrenomedullin 2a
chr21_-_33995710 0.32 ENSDART00000100508
ENSDART00000179622
ebf1b
early B cell factor 1b
chr12_-_41684729 0.31 ENSDART00000184461
jakmip3
Janus kinase and microtubule interacting protein 3
chr7_+_34620418 0.30 ENSDART00000081338
slc9a5
solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
chr8_+_28695914 0.28 ENSDART00000033386
ocstamp
osteoclast stimulatory transmembrane protein
chr17_-_49978986 0.26 ENSDART00000154728
col12a1a
collagen, type XII, alpha 1a
chr12_-_33357655 0.26 ENSDART00000066233
ENSDART00000148165
slc16a3
solute carrier family 16 (monocarboxylate transporter), member 3
chr15_-_5815006 0.26 ENSDART00000102459
rbp2a
retinol binding protein 2a, cellular
chr16_+_32051572 0.25 ENSDART00000039109
leng1
leukocyte receptor cluster (LRC) member 1
chr7_-_66868543 0.25 ENSDART00000149680
ampd3a
adenosine monophosphate deaminase 3a
chr8_-_20243389 0.25 ENSDART00000184904
acer1
alkaline ceramidase 1
chr20_+_28861629 0.24 ENSDART00000187274
ENSDART00000047826
slc10a1
solute carrier family 10 (sodium/bile acid cotransporter), member 1
chr10_-_5581487 0.23 ENSDART00000141943
syk
spleen tyrosine kinase
chr1_+_44127292 0.23 ENSDART00000160542
cabp2a
calcium binding protein 2a
chr16_-_11798994 0.22 ENSDART00000135408
cnfn
cornifelin
chr22_-_26865181 0.22 ENSDART00000138311
hmox2a
heme oxygenase 2a
chr2_+_8779164 0.22 ENSDART00000134308
zzz3
zinc finger, ZZ-type containing 3
chr10_+_35358675 0.22 ENSDART00000193263
si:dkey-259j3.5
si:dkey-259j3.5
chr5_+_36611128 0.22 ENSDART00000097684
nova1
neuro-oncological ventral antigen 1
chr6_+_28051978 0.22 ENSDART00000143218
si:ch73-194h10.2
si:ch73-194h10.2
chr14_-_413273 0.22 ENSDART00000163976
ENSDART00000179907
FAT4
FAT atypical cadherin 4
chr13_+_12761707 0.21 ENSDART00000015127
zgc:100846
zgc:100846
chr7_+_6652967 0.20 ENSDART00000102681
pnp5a
purine nucleoside phosphorylase 5a
chr1_+_51721851 0.19 ENSDART00000040397
prdx2
peroxiredoxin 2
chr14_-_4556896 0.19 ENSDART00000044678
ENSDART00000192863
GABRA2
gamma-aminobutyric acid type A receptor alpha2 subunit
chr8_+_52637507 0.19 ENSDART00000163830
si:dkey-90l8.3
si:dkey-90l8.3
chr16_+_7985886 0.18 ENSDART00000126041
ano10a
anoctamin 10a
chr20_+_28861435 0.18 ENSDART00000142678
slc10a1
solute carrier family 10 (sodium/bile acid cotransporter), member 1
chr14_+_36521005 0.17 ENSDART00000192286
TENM3
si:dkey-237h12.3
chr8_-_53044089 0.17 ENSDART00000135982
nr6a1a
nuclear receptor subfamily 6, group A, member 1a
chr11_-_2838699 0.16 ENSDART00000066189
lhfpl5a
LHFPL tetraspan subfamily member 5a
chr24_-_31425799 0.16 ENSDART00000157998
cngb3.1
cyclic nucleotide gated channel beta 3, tandem duplicate 1
chr22_-_35330532 0.16 ENSDART00000172654
FO818743.1

chr24_-_36680261 0.16 ENSDART00000059507
ccr10
chemokine (C-C motif) receptor 10
chr3_-_36701870 0.16 ENSDART00000183457
myh11b
myosin, heavy chain 11b, smooth muscle
chr16_+_35916371 0.15 ENSDART00000167208
sh3d21
SH3 domain containing 21
chr1_-_19215336 0.15 ENSDART00000162949
ENSDART00000170680
ptprdb
protein tyrosine phosphatase, receptor type, D, b
chr7_+_59020972 0.15 ENSDART00000157873
hacd1
3-hydroxyacyl-CoA dehydratase 1
chr2_+_53204750 0.15 ENSDART00000163644
zgc:165603
zgc:165603
chr20_-_37813863 0.14 ENSDART00000147529
batf3
basic leucine zipper transcription factor, ATF-like 3
chr17_+_20589553 0.14 ENSDART00000154447
si:ch73-288o11.4
si:ch73-288o11.4
chr16_+_14033121 0.13 ENSDART00000135844
rusc1
RUN and SH3 domain containing 1
chr14_+_5385855 0.13 ENSDART00000031508
lbx2
ladybird homeobox 2
chr1_-_33351780 0.13 ENSDART00000178996
gyg2
glycogenin 2
chr15_-_30505607 0.12 ENSDART00000155212
msi2b
musashi RNA-binding protein 2b
chr15_-_47115787 0.12 ENSDART00000192601
CABZ01079081.1

chr5_+_69747417 0.12 ENSDART00000153717
si:ch211-275j6.5
si:ch211-275j6.5
chr7_+_34453185 0.12 ENSDART00000173875
ENSDART00000173921
ENSDART00000173995
si:cabz01009626.1
si:cabz01009626.1
chr20_+_19512727 0.12 ENSDART00000063696
atraid
all-trans retinoic acid-induced differentiation factor
chr5_+_36870737 0.11 ENSDART00000145182
slc8a2a
solute carrier family 8 (sodium/calcium exchanger), member 2a
chr3_+_54744069 0.11 ENSDART00000134958
ENSDART00000114443
si:ch211-74m13.3
si:ch211-74m13.3
chr16_-_54971277 0.11 ENSDART00000113358
wdtc1
WD and tetratricopeptide repeats 1
chr9_-_9415000 0.10 ENSDART00000146210
si:ch211-214p13.9
si:ch211-214p13.9
chr15_-_2596125 0.10 ENSDART00000114923
dnajc30b
DnaJ (Hsp40) homolog, subfamily C, member 30b
chr4_+_16885854 0.10 ENSDART00000017726
etnk1
ethanolamine kinase 1
chr4_+_5255041 0.10 ENSDART00000137966
ccdc167
coiled-coil domain containing 167
chr6_+_52877147 0.10 ENSDART00000174370
or137-8
odorant receptor, family H, subfamily 137, member 8
chr15_+_9327252 0.10 ENSDART00000144381
sgcg
sarcoglycan, gamma
chr19_+_5480327 0.10 ENSDART00000148794
jupb
junction plakoglobin b
chr23_-_19225709 0.10 ENSDART00000080099
oard1
O-acyl-ADP-ribose deacylase 1
chr7_+_54642005 0.09 ENSDART00000171864
fgf19
fibroblast growth factor 19
chr4_-_2975461 0.09 ENSDART00000150794
plekha5
pleckstrin homology domain containing, family A member 5
chr4_+_11458078 0.08 ENSDART00000037600
ankrd16
ankyrin repeat domain 16
chr23_+_16815353 0.08 ENSDART00000142789
ENSDART00000143424
zgc:100832
zgc:100832
chr8_-_13184989 0.08 ENSDART00000135738
zgc:194990
zgc:194990
chr18_+_49969568 0.08 ENSDART00000126916
mob2b
MOB kinase activator 2b
chr13_-_37229245 0.07 ENSDART00000140923
si:dkeyp-77c8.5
si:dkeyp-77c8.5
chr23_-_37575030 0.07 ENSDART00000031875
tor1l3
torsin family 1 like 3
chr20_-_9095105 0.07 ENSDART00000140792
oma1
OMA1 zinc metallopeptidase
chr15_+_15856178 0.07 ENSDART00000080338
dusp14
dual specificity phosphatase 14
chr5_-_68074592 0.06 ENSDART00000165052
ENSDART00000018792
spag7
sperm associated antigen 7
chr1_+_35985813 0.06 ENSDART00000179634
ENSDART00000139636
ENSDART00000175902
zgc:152968
zgc:152968
chr6_+_57541776 0.06 ENSDART00000157330
necab3
N-terminal EF-hand calcium binding protein 3
chr14_+_30795559 0.05 ENSDART00000006132
cfl1
cofilin 1
chr16_+_23984179 0.05 ENSDART00000175879
apoc2
apolipoprotein C-II
chr16_-_31351419 0.05 ENSDART00000178298
ENSDART00000018091
mroh1
maestro heat-like repeat family member 1
chr15_+_34592215 0.05 ENSDART00000099776
tspan13a
tetraspanin 13a
chr4_+_20566371 0.04 ENSDART00000127576
BX248410.1

chr18_+_17827149 0.04 ENSDART00000190237
ENSDART00000189345
ZNF423
si:ch211-216l23.1
chr18_+_24919614 0.04 ENSDART00000008638
rgma
repulsive guidance molecule family member a
chr24_+_38301080 0.04 ENSDART00000105672
mybpc2b
myosin binding protein C, fast type b
chr20_-_42102416 0.04 ENSDART00000186378
ENSDART00000188253
ENSDART00000186458
slc35f1
solute carrier family 35, member F1
chr4_-_3353595 0.04 ENSDART00000009076
pik3cg
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
chr7_+_6941583 0.03 ENSDART00000160709
ENSDART00000157634
rbm14b
RNA binding motif protein 14b
chr20_+_43925266 0.03 ENSDART00000037379
clic5b
chloride intracellular channel 5b
chr10_-_40968095 0.02 ENSDART00000184104
npffr1l1
neuropeptide FF receptor 1 like 1
chr23_-_45897900 0.02 ENSDART00000149263
ftr92
finTRIM family, member 92
chr16_-_32837806 0.02 ENSDART00000003997
MCHR2
si:dkey-165n16.5
chr11_+_2506516 0.02 ENSDART00000130886
ENSDART00000189767
NABP2
si:ch73-190f16.2
chr21_-_21570134 0.02 ENSDART00000174388
or133-4
odorant receptor, family H, subfamily 133, member 4
chr22_+_737211 0.02 ENSDART00000017305
znf76
zinc finger protein 76
chr15_-_14552101 0.02 ENSDART00000171169
numbl
numb homolog (Drosophila)-like
chr22_-_10055744 0.02 ENSDART00000143686
si:ch211-222k6.2
si:ch211-222k6.2
chr25_-_1323623 0.02 ENSDART00000156532
ENSDART00000157163
ENSDART00000156062
ENSDART00000082447
ENSDART00000189175
calml4b
calmodulin-like 4b
chr24_-_21689146 0.02 ENSDART00000105917
urad
ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase
chr23_+_43255328 0.02 ENSDART00000102712
tgm2a
transglutaminase 2, C polypeptide A
chr22_-_26865361 0.02 ENSDART00000182504
hmox2a
heme oxygenase 2a
chr21_+_21195487 0.02 ENSDART00000181746
ENSDART00000184832
rictorb
RPTOR independent companion of MTOR, complex 2b
chr7_-_31922432 0.02 ENSDART00000188398
lin7c
lin-7 homolog C (C. elegans)
chr3_-_39180048 0.02 ENSDART00000049720
cdk21
cyclin-dependent kinase 21
chr4_-_61691066 0.02 ENSDART00000159114
znf1129
zinc finger protein 1129
chr1_-_17715493 0.01 ENSDART00000133027
si:dkey-256e7.8
si:dkey-256e7.8
chr6_-_52566574 0.01 ENSDART00000098421
uqcc1
ubiquinol-cytochrome c reductase complex assembly factor 1
chr15_-_35134918 0.01 ENSDART00000157196
si:ch211-272b8.7
si:ch211-272b8.7
chr6_+_36839509 0.01 ENSDART00000190605
ENSDART00000104160
zgc:110788
zgc:110788
chr21_-_45363871 0.01 ENSDART00000075443
ENSDART00000182078
ENSDART00000151106
PPP2CA
zgc:56064
chr10_+_27021164 0.01 ENSDART00000183538
BX248510.12

chr15_-_33925851 0.00 ENSDART00000187807
ENSDART00000187780
mag
myelin associated glycoprotein

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx1.2la

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0021767 mammillary body development(GO:0021767)
0.1 0.6 GO:0042984 amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.1 0.2 GO:0045579 positive regulation of B cell differentiation(GO:0045579)
0.1 0.8 GO:0002031 G-protein coupled receptor internalization(GO:0002031)
0.1 0.4 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.2 GO:0006788 heme oxidation(GO:0006788)
0.0 0.6 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.8 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.4 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.0 0.2 GO:0036268 swimming(GO:0036268)
0.0 0.1 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.0 0.4 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 0.3 GO:0098719 sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.1 GO:0045922 negative regulation of fatty acid metabolic process(GO:0045922)
0.0 0.1 GO:1904105 positive regulation of convergent extension involved in gastrulation(GO:1904105)
0.0 0.2 GO:0034312 diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.0 1.3 GO:0006096 glycolytic process(GO:0006096)
0.0 0.2 GO:1990748 response to superoxide(GO:0000303) response to oxygen radical(GO:0000305) removal of superoxide radicals(GO:0019430) cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451) cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
0.0 0.1 GO:0002159 desmosome assembly(GO:0002159)
0.0 0.4 GO:0045773 positive regulation of axon extension(GO:0045773)
0.0 0.5 GO:0003323 type B pancreatic cell development(GO:0003323)
0.0 0.3 GO:0032264 IMP salvage(GO:0032264)
0.0 0.1 GO:0030043 actin filament fragmentation(GO:0030043)
0.0 0.3 GO:0048679 regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)
0.0 0.5 GO:0001878 response to yeast(GO:0001878)
0.0 0.1 GO:0071763 nuclear membrane organization(GO:0071763)
0.0 0.2 GO:0035860 esophagus smooth muscle contraction(GO:0014846) glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.0 0.5 GO:0006376 mRNA splice site selection(GO:0006376)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0042584 chromaffin granule membrane(GO:0042584)
0.1 0.6 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.0 0.8 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.4 GO:0044295 axonal growth cone(GO:0044295)
0.0 1.2 GO:0030426 growth cone(GO:0030426)
0.0 0.1 GO:0019815 B cell receptor complex(GO:0019815)
0.0 0.1 GO:0016012 sarcoglycan complex(GO:0016012)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:0004743 pyruvate kinase activity(GO:0004743)
0.1 0.4 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 0.4 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.1 0.5 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0 0.2 GO:0017040 ceramidase activity(GO:0017040)
0.0 0.2 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.0 0.1 GO:0018812 3-hydroxyacyl-CoA dehydratase activity(GO:0018812) 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.0 0.4 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.2 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.3 GO:0015386 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0 0.4 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 0.3 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.2 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.0 0.3 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.8 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.2 GO:0005221 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.0 0.1 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 0.2 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.1 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.1 GO:0045294 alpha-catenin binding(GO:0045294)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.4 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.2 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.5 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.3 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.2 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.2 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.1 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 0.1 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 0.1 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)