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PRJEB1986: zebrafish developmental stages transcriptome

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Results for nkx2.3+nkx2.7

Z-value: 1.10

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Transcription factors associated with nkx2.3+nkx2.7

Gene Symbol Gene ID Gene Info
nkx2.7
ENSDARG00000021232 NK2 transcription factor related 7
nkx2.3
ENSDARG00000039095 NK2 homeobox 3
nkx2.3
ENSDARG00000113490 NK2 homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nkx2.7dr11_v1_chr8_-_50287949_50287949-0.624.2e-03Click!
nkx2.3dr11_v1_chr13_-_40411908_404119170.136.0e-01Click!

Activity profile of nkx2.3+nkx2.7 motif

Sorted Z-values of nkx2.3+nkx2.7 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_30244356 3.32 ENSDART00000036050
ENSDART00000150080
rs1a
retinoschisin 1a
chr1_+_44439661 3.04 ENSDART00000100309
crybb1l2
crystallin, beta B1, like 2
chr12_+_15008582 2.65 ENSDART00000003847
mylpfb
myosin light chain, phosphorylatable, fast skeletal muscle b
chr10_-_7756865 2.64 ENSDART00000114373
ENSDART00000125407
ENSDART00000016317
loxa
lysyl oxidase a
chr10_+_26800213 2.52 ENSDART00000078996
arr3a
arrestin 3a, retinal (X-arrestin)
chr6_+_41181869 2.43 ENSDART00000002046
opn1mw1
opsin 1 (cone pigments), medium-wave-sensitive, 1
chr6_+_3828560 2.19 ENSDART00000185273
ENSDART00000179091
gad1b
glutamate decarboxylase 1b
chr25_+_31277415 2.16 ENSDART00000036275
tnni2a.4
troponin I type 2a (skeletal, fast), tandem duplicate 4
chr13_-_40401870 2.16 ENSDART00000128951
nkx3.3
NK3 homeobox 3
chr21_+_7582036 2.08 ENSDART00000135485
ENSDART00000027268
otpa
orthopedia homeobox a
chr16_-_383664 2.06 ENSDART00000051693
irx4a
iroquois homeobox 4a
chr11_+_7324704 1.98 ENSDART00000031937
diras1a
DIRAS family, GTP-binding RAS-like 1a
chr4_-_4387012 1.92 ENSDART00000191836
CU468826.3
Danio rerio U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1-like (LOC100331497), mRNA.
chr14_+_29609245 1.90 ENSDART00000043058
TENM2
si:dkey-34l15.2
chr19_-_5135345 1.89 ENSDART00000151787
gnb3b
guanine nucleotide binding protein (G protein), beta polypeptide 3b
chr19_-_3193912 1.85 ENSDART00000133159
si:ch211-133n4.6
si:ch211-133n4.6
chr25_-_9805269 1.84 ENSDART00000192048
lrrc4c
leucine rich repeat containing 4C
chr9_+_51265283 1.84 ENSDART00000137426
gcgb
glucagon b
chr2_+_11205795 1.82 ENSDART00000019078
lhx8a
LIM homeobox 8a
chr14_-_3381303 1.78 ENSDART00000171601
im:7150988
im:7150988
chr25_-_10503043 1.77 ENSDART00000155404
cox8b
cytochrome c oxidase subunit 8b
chr13_+_38430466 1.74 ENSDART00000132691
adgrb3
adhesion G protein-coupled receptor B3
chr17_-_21066075 1.73 ENSDART00000078763
ENSDART00000104327
vsx1
visual system homeobox 1 homolog, chx10-like
chr3_+_25154078 1.71 ENSDART00000156973
si:ch211-256m1.8
si:ch211-256m1.8
chr12_+_16440708 1.69 ENSDART00000113810
ankrd1b
ankyrin repeat domain 1b (cardiac muscle)
chr17_-_12389259 1.69 ENSDART00000185724
snap25b
synaptosomal-associated protein, 25b
chr20_+_18551657 1.67 ENSDART00000147001
si:dkeyp-72h1.1
si:dkeyp-72h1.1
chr15_-_6247775 1.65 ENSDART00000148350
dscamb
Down syndrome cell adhesion molecule b
chr7_-_38658411 1.63 ENSDART00000109463
ENSDART00000017155
npsn
nephrosin
chr7_-_28148310 1.62 ENSDART00000044208
lmo1
LIM domain only 1
chr22_+_18389271 1.61 ENSDART00000088270
yjefn3
YjeF N-terminal domain containing 3
chr9_-_22057658 1.60 ENSDART00000101944
crygmxl1
crystallin, gamma MX, like 1
chr24_-_6158933 1.60 ENSDART00000021609
gad2
glutamate decarboxylase 2
chr10_-_11385155 1.57 ENSDART00000064214
plac8.1
placenta-specific 8, tandem duplicate 1
chr20_-_39271844 1.56 ENSDART00000192708
clu
clusterin
chr15_-_12319065 1.55 ENSDART00000162973
ENSDART00000170543
fxyd6
FXYD domain containing ion transport regulator 6
chr5_+_32206378 1.55 ENSDART00000126873
ENSDART00000051361
myhz2
myosin, heavy polypeptide 2, fast muscle specific
chr13_+_23988442 1.53 ENSDART00000010918
agt
angiotensinogen
chr13_+_25449681 1.52 ENSDART00000101328
atoh7
atonal bHLH transcription factor 7
chr6_-_41229787 1.50 ENSDART00000065013
synpr
synaptoporin
chr20_-_47732703 1.50 ENSDART00000193975
tfap2d
transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
chr12_+_24342303 1.45 ENSDART00000111239
nrxn1a
neurexin 1a
chr10_+_9372702 1.43 ENSDART00000021100
lhx6
LIM homeobox 6
chr19_-_42391383 1.42 ENSDART00000110075
ENSDART00000087002
plekho1a
pleckstrin homology domain containing, family O member 1a
chr20_+_28861629 1.37 ENSDART00000187274
ENSDART00000047826
slc10a1
solute carrier family 10 (sodium/bile acid cotransporter), member 1
chr4_+_21129752 1.37 ENSDART00000169764
syt1a
synaptotagmin Ia
chr1_-_59287410 1.36 ENSDART00000158011
ENSDART00000170580
col5a3b
collagen, type V, alpha 3b
chr3_+_29714775 1.34 ENSDART00000041388
cacng2a
calcium channel, voltage-dependent, gamma subunit 2a
chr18_+_27318589 1.34 ENSDART00000037813
cd81b
CD81 molecule b
chr15_-_15357178 1.34 ENSDART00000106120
ywhag2
3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 2
chr5_-_10946232 1.32 ENSDART00000163139
ENSDART00000031265
rtn4r
reticulon 4 receptor
chr24_+_22759451 1.32 ENSDART00000135392
si:dkey-7n6.2
si:dkey-7n6.2
chr2_+_31665836 1.31 ENSDART00000135411
ENSDART00000143914
si:ch211-106h4.12
si:ch211-106h4.12
chr7_+_66565930 1.30 ENSDART00000154597
tmem176l.3b
transmembrane protein 176l.3b
chr12_-_25916530 1.29 ENSDART00000186386
sncgb
synuclein, gamma b (breast cancer-specific protein 1)
chr20_-_40755614 1.28 ENSDART00000061247
cx32.3
connexin 32.3
chr14_-_33894915 1.27 ENSDART00000143290
urp1
urotensin-related peptide 1
chr7_-_28147838 1.24 ENSDART00000158921
lmo1
LIM domain only 1
chr20_+_37295006 1.24 ENSDART00000153137
cx23
connexin 23
chr6_+_40661703 1.23 ENSDART00000142492
eno1b
enolase 1b, (alpha)
chr3_-_28250722 1.22 ENSDART00000165936
rbfox1
RNA binding fox-1 homolog 1
chr19_+_1184878 1.22 ENSDART00000163539
scrt1a
scratch family zinc finger 1a
chr7_-_24699985 1.22 ENSDART00000052802
calb2b
calbindin 2b
chr25_+_20089986 1.22 ENSDART00000143441
ENSDART00000184073
tnni4b.2
troponin I4b, tandem duplicate 2
chr7_+_73397283 1.21 ENSDART00000174390
CABZ01081780.1

chr12_+_39685485 1.18 ENSDART00000163403
LO017650.1

chr10_-_8060573 1.18 ENSDART00000147104
ENSDART00000099030
si:ch211-251f6.6
si:ch211-251f6.6
chr7_+_28612671 1.17 ENSDART00000019991
slc7a6os
solute carrier family 7, member 6 opposite strand
chr1_-_50859053 1.17 ENSDART00000132779
ENSDART00000137648
si:dkeyp-123h10.2
si:dkeyp-123h10.2
chr2_+_11206317 1.15 ENSDART00000144982
lhx8a
LIM homeobox 8a
chr14_-_11507211 1.14 ENSDART00000186873
ENSDART00000109181
ENSDART00000186166
ENSDART00000186986
zgc:174917
zgc:174917
chr9_-_31915423 1.13 ENSDART00000060051
fgf14
fibroblast growth factor 14
chr8_-_33114202 1.13 ENSDART00000098840
ralgps1
Ral GEF with PH domain and SH3 binding motif 1
chr20_-_34090740 1.13 ENSDART00000062539
ENSDART00000008140
pdcb
phosducin b
chr21_+_40092301 1.11 ENSDART00000145150
serpinf2a
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2a
chr19_+_13099541 1.11 ENSDART00000171607
ENSDART00000165448
ENSDART00000170365
rims2b
regulating synaptic membrane exocytosis 2b
chr19_+_37848830 1.10 ENSDART00000042276
ENSDART00000180872
nxph1
neurexophilin 1
chr18_+_924949 1.09 ENSDART00000170888
ENSDART00000193163
pkma
pyruvate kinase M1/2a
chr3_-_36612877 1.09 ENSDART00000167164
si:dkeyp-72e1.7
si:dkeyp-72e1.7
chr10_+_29698467 1.09 ENSDART00000163402
dlg2
discs, large homolog 2 (Drosophila)
chr5_-_42272517 1.08 ENSDART00000137692
ENSDART00000164363
si:ch211-207c6.2
si:ch211-207c6.2
chr8_+_24861264 1.07 ENSDART00000099607
slc6a17
solute carrier family 6 (neutral amino acid transporter), member 17
chr25_-_7683316 1.07 ENSDART00000128820
si:ch211-286c4.6
si:ch211-286c4.6
chr10_+_25726694 1.07 ENSDART00000140308
ugt5d1
UDP glucuronosyltransferase 5 family, polypeptide D1
chr16_+_9540033 1.05 ENSDART00000149574
ca14
carbonic anhydrase XIV
chr22_+_27090136 1.05 ENSDART00000136770
si:dkey-246e1.3
si:dkey-246e1.3
chr22_-_33679277 1.05 ENSDART00000169948
FO904977.1

chr5_+_37854685 1.03 ENSDART00000051222
ENSDART00000185283
ins
preproinsulin
chr16_+_20161805 1.01 ENSDART00000192146
c16h2orf66
chromosome 16 C2orf66 homolog
chr20_+_28861435 1.00 ENSDART00000142678
slc10a1
solute carrier family 10 (sodium/bile acid cotransporter), member 1
chr11_-_6188413 0.99 ENSDART00000109972
ccl44
chemokine (C-C motif) ligand 44
chr16_+_32059785 0.99 ENSDART00000134459
si:dkey-40m6.8
si:dkey-40m6.8
chr21_+_18353703 0.97 ENSDART00000181396
ENSDART00000166359
si:ch73-287m6.1
si:ch73-287m6.1
chr21_+_28958471 0.96 ENSDART00000144331
ENSDART00000005929
ppp3ca
protein phosphatase 3, catalytic subunit, alpha isozyme
chr1_+_40023640 0.96 ENSDART00000101623
lgi2b
leucine-rich repeat LGI family, member 2b
chr23_+_19590006 0.95 ENSDART00000021231
slmapb
sarcolemma associated protein b
chr14_+_49135264 0.95 ENSDART00000084119
si:ch1073-44g3.1
si:ch1073-44g3.1
chr10_+_37137464 0.95 ENSDART00000114909
cuedc1a
CUE domain containing 1a
chr1_-_22512063 0.94 ENSDART00000031546
ENSDART00000190987
chrna6
cholinergic receptor, nicotinic, alpha 6
chr13_+_22479988 0.93 ENSDART00000188182
ENSDART00000192972
ENSDART00000178372
ldb3a
LIM domain binding 3a
chr22_-_13851297 0.93 ENSDART00000080306
s100b
S100 calcium binding protein, beta (neural)
chr24_+_2519761 0.92 ENSDART00000106619
nrn1a
neuritin 1a
chr3_-_30061985 0.91 ENSDART00000189583
ppfia3
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr4_+_12612723 0.89 ENSDART00000133767
lmo3
LIM domain only 3
chr1_-_23308225 0.88 ENSDART00000137567
ENSDART00000008201
smim14
small integral membrane protein 14
chr16_+_26766423 0.87 ENSDART00000048036
gem
GTP binding protein overexpressed in skeletal muscle
chr22_-_10470663 0.87 ENSDART00000143352
omd
osteomodulin
chr1_-_45341760 0.86 ENSDART00000149183
ENSDART00000148289
ENSDART00000110390
zgc:101679
zgc:101679
chr23_+_28322986 0.86 ENSDART00000134710
birc5b
baculoviral IAP repeat containing 5b
chr8_+_31821396 0.84 ENSDART00000077053
plcxd3
phosphatidylinositol-specific phospholipase C, X domain containing 3
chr21_-_43015383 0.83 ENSDART00000065097
dpysl3
dihydropyrimidinase-like 3
chr19_+_43297546 0.83 ENSDART00000168002
laptm5
lysosomal protein transmembrane 5
chr6_-_10988741 0.82 ENSDART00000090709
coq7
coenzyme Q7 homolog, ubiquinone (yeast)
chr19_-_28789404 0.82 ENSDART00000191453
ENSDART00000026992
sox4a
SRY (sex determining region Y)-box 4a
chr4_-_6459863 0.82 ENSDART00000138367
foxp2
forkhead box P2
chr16_+_46459680 0.81 ENSDART00000101698
rpz3
rapunzel 3
chr13_+_22480496 0.80 ENSDART00000136863
ENSDART00000131870
ENSDART00000078720
ENSDART00000078740
ENSDART00000139218
ldb3a
LIM domain binding 3a
chr1_+_44582369 0.80 ENSDART00000003022
ENSDART00000137980
med19b
mediator complex subunit 19b
chr24_+_34606966 0.79 ENSDART00000105477
lrrtm2
leucine rich repeat transmembrane neuronal 2
chr9_-_51323545 0.79 ENSDART00000139316
slc4a10b
solute carrier family 4, sodium bicarbonate transporter, member 10b
chr2_+_20332044 0.78 ENSDART00000112131
plppr4a
phospholipid phosphatase related 4a
chr19_-_7358184 0.78 ENSDART00000092379
oxr1b
oxidation resistance 1b
chr6_-_15641686 0.78 ENSDART00000135583
mlpha
melanophilin a
chr23_+_17387325 0.78 ENSDART00000083947
ptk6b
PTK6 protein tyrosine kinase 6b
chr17_-_29902187 0.77 ENSDART00000009104
esrrb
estrogen-related receptor beta
chr12_+_5081759 0.77 ENSDART00000164178
prrt2
proline-rich transmembrane protein 2
chr10_+_22381802 0.77 ENSDART00000112484
nlgn2b
neuroligin 2b
chr1_+_45085194 0.76 ENSDART00000193863
si:ch211-151p13.8
si:ch211-151p13.8
chr6_+_13024448 0.74 ENSDART00000104768
pnkd
paroxysmal nonkinesigenic dyskinesia
chr11_+_30057762 0.73 ENSDART00000164139
nhsb
Nance-Horan syndrome b (congenital cataracts and dental anomalies)
chr8_+_37465380 0.73 ENSDART00000003954
mapkapk2b
mitogen-activated protein kinase-activated protein kinase 2b
chr20_-_28800999 0.73 ENSDART00000049462
rab15
RAB15, member RAS oncogene family
chr21_-_42100471 0.73 ENSDART00000166148
gabra1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr18_+_10884996 0.72 ENSDART00000147613
mical3a
microtubule associated monooxygenase, calponin and LIM domain containing 3a
chr10_+_25355308 0.72 ENSDART00000100415
map3k7cl
map3k7 C-terminal like
chr25_-_18953322 0.72 ENSDART00000155927
si:ch211-68a17.7
si:ch211-68a17.7
chr8_-_46894362 0.71 ENSDART00000111124
acot7
acyl-CoA thioesterase 7
chr20_+_33875256 0.71 ENSDART00000002554
rxrgb
retinoid X receptor, gamma b
chr11_-_33960318 0.70 ENSDART00000087597
col6a2
collagen, type VI, alpha 2
chr11_+_25276748 0.70 ENSDART00000126211
cyldb
cylindromatosis (turban tumor syndrome), b
chr6_-_11780070 0.70 ENSDART00000151195
march7
membrane-associated ring finger (C3HC4) 7
chr8_+_22582146 0.69 ENSDART00000157655
ENSDART00000189892
CT583651.2

chr7_+_66822229 0.69 ENSDART00000112109
lyve1a
lymphatic vessel endothelial hyaluronic receptor 1a
chr19_+_9786722 0.68 ENSDART00000138310
cacng6a
calcium channel, voltage-dependent, gamma subunit 6a
chr9_-_18735256 0.68 ENSDART00000143165
tsc22d1
TSC22 domain family, member 1
chr5_+_23622177 0.68 ENSDART00000121504
cx27.5
connexin 27.5
chr18_+_27300700 0.68 ENSDART00000140444
plekha7a
pleckstrin homology domain containing, family A member 7a
chr13_+_28417297 0.68 ENSDART00000043658
slc2a15a
solute carrier family 2 (facilitated glucose transporter), member 15a
chr9_+_40939336 0.67 ENSDART00000100386
mstnb
myostatin b
chr7_-_35515931 0.67 ENSDART00000193324
irx6a
iroquois homeobox 6a
chr20_+_38031439 0.66 ENSDART00000153208
galnt14
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chr25_-_4482449 0.66 ENSDART00000056278
ENSDART00000149425
slc25a22a
solute carrier family 25 member 22a
chr17_-_24680965 0.66 ENSDART00000154880
arhgef33
Rho guanine nucleotide exchange factor (GEF) 33
chr5_-_71995108 0.65 ENSDART00000124587
fam78ab
family with sequence similarity 78, member Ab
chr24_+_25069609 0.65 ENSDART00000115165
amer2
APC membrane recruitment protein 2
chr1_+_33969015 0.65 ENSDART00000042984
ENSDART00000146530
epha6
eph receptor A6
chr5_-_67145505 0.65 ENSDART00000011295
rom1a
retinal outer segment membrane protein 1a
chr16_+_13818500 0.65 ENSDART00000135245
flcn
folliculin
chr19_-_13808630 0.65 ENSDART00000166895
ENSDART00000187670
ctgfb
connective tissue growth factor b
chr19_+_26718074 0.64 ENSDART00000134455
zgc:100906
zgc:100906
chr25_+_14165447 0.64 ENSDART00000145387
shank2
SH3 and multiple ankyrin repeat domains 2
chr1_+_52929185 0.64 ENSDART00000147683
inpp4b
inositol polyphosphate-4-phosphatase type II B
chr5_+_26156079 0.63 ENSDART00000088141
ankrd34bb
ankyrin repeat domain 34Bb
chr6_+_40714811 0.62 ENSDART00000153868
ccdc36
coiled-coil domain containing 36
chr20_+_34717403 0.61 ENSDART00000034252
pnocb
prepronociceptin b
chr10_+_33744098 0.60 ENSDART00000147775
rxfp2a
relaxin/insulin-like family peptide receptor 2a
chr17_+_29276544 0.59 ENSDART00000049399
ankrd9
ankyrin repeat domain 9
chr14_+_40685469 0.59 ENSDART00000172839
tnmd
tenomodulin
chr18_-_17485419 0.58 ENSDART00000018764
foxl1
forkhead box L1
chr6_-_25163722 0.58 ENSDART00000192225
znf326
zinc finger protein 326
chr7_+_42208859 0.57 ENSDART00000148643
phkb
phosphorylase kinase, beta
chr16_-_47483142 0.57 ENSDART00000147072
cthrc1b
collagen triple helix repeat containing 1b
chr1_+_42224769 0.57 ENSDART00000177496
ENSDART00000184778
ENSDART00000110860
ctnna2
catenin (cadherin-associated protein), alpha 2
chr6_+_52350443 0.57 ENSDART00000151612
ENSDART00000151349
si:ch211-239j9.1
si:ch211-239j9.1
chr14_+_25465346 0.56 ENSDART00000173436
si:dkey-280e21.3
si:dkey-280e21.3
chr1_-_36151377 0.56 ENSDART00000037516
znf827
zinc finger protein 827
chr13_+_25396896 0.56 ENSDART00000041257
gsto2
glutathione S-transferase omega 2
chr21_+_22404662 0.56 ENSDART00000183455
lmbrd2b
LMBR1 domain containing 2b
chr19_-_44089509 0.56 ENSDART00000189136
rad21b
RAD21 cohesin complex component b
chr17_-_44247707 0.56 ENSDART00000126097
otx2b
orthodenticle homeobox 2b
chr19_-_48391415 0.55 ENSDART00000170726
ENSDART00000169577
si:ch73-359m17.2
si:ch73-359m17.2
chr15_-_28094256 0.55 ENSDART00000142041
ENSDART00000132153
ENSDART00000146657
ENSDART00000048720
cryba1a
crystallin, beta A1a
chr17_+_13664442 0.55 ENSDART00000171689
lrfn5a
leucine rich repeat and fibronectin type III domain containing 5a
chr4_+_18494857 0.55 ENSDART00000066986
si:dkey-202b22.6
si:dkey-202b22.6
chr21_+_9628854 0.55 ENSDART00000161753
ENSDART00000160711
mapk10
mitogen-activated protein kinase 10
chr19_-_5865766 0.53 ENSDART00000191007
LO018585.1

chr25_+_8407892 0.53 ENSDART00000153536
muc5.2
mucin 5.2
chr18_+_39649660 0.53 ENSDART00000149859
gldn
gliomedin
chr12_+_33038757 0.53 ENSDART00000153146
rbfox3a
RNA binding fox-1 homolog 3a
chr23_-_1348933 0.52 ENSDART00000168981
CABZ01078120.1

chr4_-_14915268 0.52 ENSDART00000067040
si:dkey-180p18.9
si:dkey-180p18.9
chr23_+_44741500 0.52 ENSDART00000166421
atp1b2a
ATPase Na+/K+ transporting subunit beta 2a
chr13_+_15182149 0.52 ENSDART00000193644
ENSDART00000134421
ENSDART00000086281
mavs
mitochondrial antiviral signaling protein
chr6_+_45494227 0.51 ENSDART00000159863
cntn4
contactin 4
chr23_-_36823932 0.51 ENSDART00000142305
hipk1a
homeodomain interacting protein kinase 1a
chr7_+_32722227 0.51 ENSDART00000126565
si:ch211-150g13.3
si:ch211-150g13.3
chr8_-_50147948 0.50 ENSDART00000149010
hp
haptoglobin
chr13_+_25397098 0.50 ENSDART00000132953
gsto2
glutathione S-transferase omega 2
chr15_-_1822548 0.50 ENSDART00000082026
ENSDART00000180230
mmp28
matrix metallopeptidase 28
chr6_+_23887314 0.50 ENSDART00000163188
znf648
zinc finger protein 648

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx2.3+nkx2.7

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.8 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.6 1.7 GO:0048341 paraxial mesoderm morphogenesis(GO:0048340) paraxial mesoderm formation(GO:0048341)
0.4 1.6 GO:0010874 regulation of cholesterol efflux(GO:0010874)
0.4 2.0 GO:0061551 trigeminal ganglion development(GO:0061551)
0.4 1.1 GO:0015824 proline transport(GO:0015824)
0.3 1.7 GO:0016322 neuron remodeling(GO:0016322)
0.3 2.1 GO:0035176 mammillary body development(GO:0021767) social behavior(GO:0035176) intraspecies interaction between organisms(GO:0051703)
0.3 1.2 GO:1900271 regulation of presynaptic cytosolic calcium ion concentration(GO:0099509) regulation of long-term synaptic potentiation(GO:1900271)
0.3 0.9 GO:0000212 meiotic spindle organization(GO:0000212)
0.3 0.3 GO:0014808 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0010880) release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0014808) sarcoplasmic reticulum calcium ion transport(GO:0070296) calcium ion transport from endoplasmic reticulum to cytosol(GO:1903514)
0.3 1.0 GO:0030858 positive regulation of epithelial cell differentiation(GO:0030858) negative regulation of behavior(GO:0048521) negative regulation of feeding behavior(GO:2000252)
0.2 0.7 GO:0006089 lactate metabolic process(GO:0006089)
0.2 0.7 GO:0045218 zonula adherens maintenance(GO:0045218)
0.2 1.3 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.2 2.5 GO:0002031 G-protein coupled receptor internalization(GO:0002031)
0.2 0.8 GO:0010259 multicellular organism aging(GO:0010259)
0.2 0.7 GO:0051876 pigment granule dispersal(GO:0051876)
0.2 0.9 GO:1901842 regulation of high voltage-gated calcium channel activity(GO:1901841) negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.2 0.7 GO:0045843 negative regulation of striated muscle tissue development(GO:0045843) negative regulation of muscle tissue development(GO:1901862)
0.2 2.3 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.2 1.1 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.2 2.2 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.1 0.9 GO:0048069 eye pigmentation(GO:0048069)
0.1 0.7 GO:0070208 protein heterotrimerization(GO:0070208)
0.1 0.6 GO:0051823 regulation of synapse structural plasticity(GO:0051823)
0.1 0.7 GO:1902514 calcium ion transmembrane transport via high voltage-gated calcium channel(GO:0061577) regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1902514)
0.1 2.3 GO:0018057 peptidyl-lysine oxidation(GO:0018057)
0.1 3.0 GO:0021884 forebrain neuron development(GO:0021884)
0.1 1.7 GO:0016540 protein autoprocessing(GO:0016540)
0.1 2.1 GO:0048923 posterior lateral line neuromast hair cell differentiation(GO:0048923)
0.1 0.7 GO:0017062 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.1 0.6 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.1 0.3 GO:0036378 calcitriol biosynthetic process from calciol(GO:0036378) vitamin D biosynthetic process(GO:0042368) cellular alcohol metabolic process(GO:0044107) cellular alcohol biosynthetic process(GO:0044108)
0.1 2.4 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1 0.7 GO:1903846 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.1 1.2 GO:0097104 presynaptic membrane organization(GO:0097090) postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105)
0.1 1.5 GO:0032088 negative regulation of NF-kappaB transcription factor activity(GO:0032088)
0.1 0.5 GO:0039528 cytoplasmic pattern recognition receptor signaling pathway in response to virus(GO:0039528) cellular response to virus(GO:0098586)
0.1 0.2 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
0.1 0.3 GO:1903673 mitotic cytokinetic process(GO:1902410) mitotic cleavage furrow formation(GO:1903673)
0.1 2.2 GO:0048936 peripheral nervous system neuron axonogenesis(GO:0048936)
0.1 0.5 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.1 0.5 GO:0060827 regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060827)
0.1 1.4 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.1 1.1 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.1 0.2 GO:0043416 regulation of skeletal muscle tissue regeneration(GO:0043416)
0.1 0.6 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.1 0.4 GO:0097250 mitochondrial respiratory chain supercomplex assembly(GO:0097250)
0.1 0.7 GO:1904071 presynaptic active zone assembly(GO:1904071)
0.1 3.6 GO:0003009 skeletal muscle contraction(GO:0003009)
0.1 0.3 GO:2001293 malonyl-CoA metabolic process(GO:2001293)
0.1 0.7 GO:0015813 acidic amino acid transport(GO:0015800) aspartate transport(GO:0015810) L-glutamate transport(GO:0015813) malate-aspartate shuttle(GO:0043490)
0.1 1.0 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.1 0.2 GO:0003156 regulation of organ formation(GO:0003156)
0.1 0.4 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.1 1.3 GO:0008345 larval locomotory behavior(GO:0008345) larval behavior(GO:0030537)
0.1 0.2 GO:0051660 establishment of centrosome localization(GO:0051660)
0.1 0.8 GO:0051481 negative regulation of cytosolic calcium ion concentration(GO:0051481) negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.1 0.3 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.1 1.6 GO:0070593 dendrite self-avoidance(GO:0070593)
0.1 0.6 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.1 0.7 GO:0051452 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.1 0.3 GO:0021877 forebrain neuron fate commitment(GO:0021877)
0.0 1.1 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.2 GO:0048313 organelle inheritance(GO:0048308) Golgi inheritance(GO:0048313)
0.0 0.3 GO:0097476 spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477)
0.0 0.6 GO:0045762 activation of adenylate cyclase activity(GO:0007190) positive regulation of cAMP metabolic process(GO:0030816) positive regulation of cAMP biosynthetic process(GO:0030819) positive regulation of adenylate cyclase activity(GO:0045762)
0.0 0.4 GO:0000050 urea cycle(GO:0000050) urea metabolic process(GO:0019627)
0.0 1.0 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 0.3 GO:0031179 peptide modification(GO:0031179)
0.0 2.1 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.7 GO:0001990 regulation of systemic arterial blood pressure by hormone(GO:0001990)
0.0 0.6 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.0 5.2 GO:0002088 lens development in camera-type eye(GO:0002088)
0.0 0.6 GO:0045471 response to ethanol(GO:0045471)
0.0 1.8 GO:0036269 swimming behavior(GO:0036269)
0.0 0.4 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 0.1 GO:0090219 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) negative regulation of lipid kinase activity(GO:0090219)
0.0 2.2 GO:0006119 oxidative phosphorylation(GO:0006119)
0.0 0.3 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889)
0.0 0.3 GO:0021634 optic nerve formation(GO:0021634)
0.0 0.7 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.0 0.3 GO:0070206 protein trimerization(GO:0070206) protein homotrimerization(GO:0070207)
0.0 0.1 GO:0070640 vitamin D3 metabolic process(GO:0070640)
0.0 0.8 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.4 GO:0033198 response to ATP(GO:0033198)
0.0 0.2 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.0 0.4 GO:0021654 rhombomere boundary formation(GO:0021654)
0.0 0.9 GO:0030500 regulation of bone mineralization(GO:0030500) regulation of biomineral tissue development(GO:0070167)
0.0 0.6 GO:0014823 response to activity(GO:0014823)
0.0 1.1 GO:0021854 hypothalamus development(GO:0021854)
0.0 0.1 GO:0071632 optomotor response(GO:0071632)
0.0 0.2 GO:0045625 neutrophil apoptotic process(GO:0001781) regulation of T-helper 1 type immune response(GO:0002825) positive regulation of T-helper 1 type immune response(GO:0002827) negative regulation of type 2 immune response(GO:0002829) inflammatory cell apoptotic process(GO:0006925) regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of phospholipase A2 activity(GO:0032429) interleukin-2 production(GO:0032623) regulation of interleukin-2 production(GO:0032663) positive regulation of interleukin-2 production(GO:0032743) myeloid cell apoptotic process(GO:0033028) regulation of neutrophil apoptotic process(GO:0033029) positive regulation of neutrophil apoptotic process(GO:0033031) regulation of myeloid cell apoptotic process(GO:0033032) positive regulation of myeloid cell apoptotic process(GO:0033034) T-helper 1 type immune response(GO:0042088) negative regulation of CD4-positive, alpha-beta T cell differentiation(GO:0043371) positive regulation of CD4-positive, alpha-beta T cell differentiation(GO:0043372) T-helper 1 cell differentiation(GO:0045063) negative regulation of T cell differentiation(GO:0045581) regulation of T-helper cell differentiation(GO:0045622) negative regulation of T-helper cell differentiation(GO:0045623) positive regulation of T-helper cell differentiation(GO:0045624) regulation of T-helper 1 cell differentiation(GO:0045625) positive regulation of T-helper 1 cell differentiation(GO:0045627) regulation of T-helper 2 cell differentiation(GO:0045628) negative regulation of T-helper 2 cell differentiation(GO:0045629) positive regulation of fatty acid biosynthetic process(GO:0045723) positive regulation of alpha-beta T cell differentiation(GO:0046638) negative regulation of alpha-beta T cell differentiation(GO:0046639) neutrophil clearance(GO:0097350) negative regulation of phospholipase A2 activity(GO:1900138) positive regulation of CD4-positive, alpha-beta T cell activation(GO:2000516) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.0 0.4 GO:0007398 ectoderm development(GO:0007398)
0.0 0.7 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.0 0.2 GO:0045852 pH elevation(GO:0045852) intracellular pH elevation(GO:0051454)
0.0 0.5 GO:0030007 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.0 0.5 GO:0051932 synaptic transmission, GABAergic(GO:0051932)
0.0 0.1 GO:0003322 pancreatic A cell development(GO:0003322)
0.0 0.1 GO:0007624 ultradian rhythm(GO:0007624)
0.0 0.2 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.0 2.0 GO:0032869 cellular response to insulin stimulus(GO:0032869)
0.0 0.2 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.0 0.9 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.0 0.3 GO:0006032 chitin catabolic process(GO:0006032)
0.0 0.2 GO:0060005 reflex(GO:0060004) vestibular reflex(GO:0060005)
0.0 0.1 GO:0034138 toll-like receptor 2 signaling pathway(GO:0034134) toll-like receptor 3 signaling pathway(GO:0034138)
0.0 0.1 GO:0030859 polarized epithelial cell differentiation(GO:0030859) determination of intestine left/right asymmetry(GO:0071908)
0.0 0.2 GO:0060118 vestibular receptor cell differentiation(GO:0060114) vestibular receptor cell development(GO:0060118)
0.0 0.5 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0 0.1 GO:0046104 deoxyribonucleoside metabolic process(GO:0009120) thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
0.0 0.7 GO:0032526 response to retinoic acid(GO:0032526)
0.0 1.3 GO:0008217 regulation of blood pressure(GO:0008217)
0.0 0.5 GO:0035924 cellular response to vascular endothelial growth factor stimulus(GO:0035924)
0.0 1.1 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 1.1 GO:1901214 regulation of neuron death(GO:1901214)
0.0 0.5 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.2 GO:0070933 histone H4 deacetylation(GO:0070933)
0.0 1.1 GO:0001946 lymphangiogenesis(GO:0001946)
0.0 0.2 GO:0014034 neural crest cell fate commitment(GO:0014034) neural crest cell fate specification(GO:0014036)
0.0 1.9 GO:0042594 response to starvation(GO:0042594)
0.0 0.1 GO:0060074 synapse maturation(GO:0060074)
0.0 0.4 GO:0051289 protein homotetramerization(GO:0051289)
0.0 0.2 GO:0022900 electron transport chain(GO:0022900)
0.0 0.1 GO:0001958 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 0.0 GO:0032602 chemokine production(GO:0032602)
0.0 0.4 GO:0071875 adrenergic receptor signaling pathway(GO:0071875)
0.0 0.2 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.1 GO:0070166 enamel mineralization(GO:0070166)
0.0 0.4 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.0 0.3 GO:0015671 oxygen transport(GO:0015671)
0.0 0.4 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.0 0.6 GO:0035138 pectoral fin morphogenesis(GO:0035138)
0.0 0.5 GO:0044243 collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243)
0.0 0.4 GO:0090148 membrane fission(GO:0090148)
0.0 0.2 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.0 0.6 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.0 0.2 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 1.1 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.0 0.8 GO:0030042 actin filament depolymerization(GO:0030042)
0.0 0.7 GO:0007254 JNK cascade(GO:0007254)
0.0 0.2 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.0 0.3 GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage(GO:0008630)
0.0 0.2 GO:0051131 proteasome assembly(GO:0043248) chaperone-mediated protein complex assembly(GO:0051131)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.9 GO:0042583 chromaffin granule(GO:0042583)
0.3 1.7 GO:0043083 synaptic cleft(GO:0043083)
0.3 1.7 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.3 0.8 GO:0060077 inhibitory synapse(GO:0060077)
0.2 1.0 GO:0005955 calcineurin complex(GO:0005955)
0.1 0.6 GO:0044609 DBIRD complex(GO:0044609)
0.1 0.9 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.1 0.7 GO:0005915 cell-cell adherens junction(GO:0005913) zonula adherens(GO:0005915)
0.1 0.7 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 1.8 GO:0045277 respiratory chain complex IV(GO:0045277)
0.1 0.8 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.1 0.9 GO:0032593 insulin-responsive compartment(GO:0032593)
0.1 3.1 GO:0043679 axon terminus(GO:0043679)
0.1 0.6 GO:0030892 nuclear cohesin complex(GO:0000798) mitotic cohesin complex(GO:0030892) nuclear mitotic cohesin complex(GO:0034990) nuclear meiotic cohesin complex(GO:0034991)
0.1 3.3 GO:0005861 troponin complex(GO:0005861)
0.1 0.7 GO:0098982 GABA-ergic synapse(GO:0098982)
0.1 0.4 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 0.7 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.1 0.3 GO:0031673 H zone(GO:0031673)
0.1 1.1 GO:0048788 cytoskeleton of presynaptic active zone(GO:0048788) presynaptic active zone cytoplasmic component(GO:0098831)
0.1 0.3 GO:0005749 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.1 0.5 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.0 0.6 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 0.2 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.0 2.5 GO:0099634 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.0 1.9 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.2 GO:0030893 meiotic cohesin complex(GO:0030893)
0.0 0.3 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.0 2.4 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.3 GO:0035060 brahma complex(GO:0035060)
0.0 1.7 GO:0031941 filamentous actin(GO:0031941)
0.0 1.2 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 1.3 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.2 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.4 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.3 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.2 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.0 0.4 GO:0000815 ESCRT III complex(GO:0000815)
0.0 1.4 GO:0005746 mitochondrial respiratory chain(GO:0005746)
0.0 0.5 GO:0005639 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0 0.3 GO:0048179 activin receptor complex(GO:0048179)
0.0 1.5 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 0.9 GO:0048786 presynaptic active zone(GO:0048786)
0.0 1.3 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.9 GO:0005876 spindle microtubule(GO:0005876)
0.0 0.3 GO:0035267 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 0.4 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.2 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.8 GO:0030426 growth cone(GO:0030426)
0.0 0.6 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 0.5 GO:0016605 PML body(GO:0016605)
0.0 1.1 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.1 GO:0045171 intercellular bridge(GO:0045171)
0.0 1.1 GO:0005581 collagen trimer(GO:0005581)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.8 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.4 1.3 GO:1903136 cuprous ion binding(GO:1903136)
0.4 1.7 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.4 2.4 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.4 1.8 GO:0031769 glucagon receptor binding(GO:0031769)
0.4 1.1 GO:0045174 glutathione dehydrogenase (ascorbate) activity(GO:0045174)
0.3 1.7 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.2 0.9 GO:0044548 S100 protein binding(GO:0044548)
0.2 0.7 GO:0070097 delta-catenin binding(GO:0070097)
0.2 1.3 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.2 1.1 GO:0004743 pyruvate kinase activity(GO:0004743)
0.2 1.0 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 2.3 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 0.4 GO:0004771 sterol esterase activity(GO:0004771)
0.1 1.9 GO:0031682 G-protein gamma-subunit binding(GO:0031682)
0.1 0.3 GO:0030343 vitamin D3 25-hydroxylase activity(GO:0030343) cholesterol 26-hydroxylase activity(GO:0031073)
0.1 0.4 GO:0051059 NF-kappaB binding(GO:0051059)
0.1 0.7 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.1 2.7 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 1.6 GO:0048495 Roundabout binding(GO:0048495)
0.1 0.3 GO:0000104 succinate dehydrogenase activity(GO:0000104)
0.1 0.6 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316)
0.1 1.2 GO:0008503 benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)
0.1 1.7 GO:0051393 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.1 0.5 GO:0030548 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.1 2.2 GO:0016675 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.7 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 2.8 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 1.6 GO:0016854 racemase and epimerase activity(GO:0016854)
0.1 0.8 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.1 0.9 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)
0.1 0.3 GO:0008131 primary amine oxidase activity(GO:0008131)
0.1 5.2 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 0.4 GO:0016880 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.1 0.8 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.1 1.6 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 1.6 GO:0005246 calcium channel regulator activity(GO:0005246)
0.1 0.8 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 0.7 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.1 0.4 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.1 0.5 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1 1.3 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 2.0 GO:0019003 GDP binding(GO:0019003)
0.1 0.2 GO:0017064 fatty acid amide hydrolase activity(GO:0017064)
0.1 0.3 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.1 1.4 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 1.6 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.0 0.6 GO:0031628 opioid receptor binding(GO:0031628)
0.0 1.2 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.4 GO:0005522 profilin binding(GO:0005522)
0.0 0.7 GO:0098882 structural constituent of presynaptic active zone(GO:0098882)
0.0 0.4 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 1.9 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.3 GO:0036374 peptidyltransferase activity(GO:0000048) glutathione hydrolase activity(GO:0036374)
0.0 0.4 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.2 GO:0009881 photoreceptor activity(GO:0009881)
0.0 0.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.3 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.7 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 0.2 GO:0032052 bile acid binding(GO:0032052)
0.0 0.4 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 0.8 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 1.4 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.2 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
0.0 0.8 GO:0042577 lipid phosphatase activity(GO:0042577)
0.0 0.2 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.0 0.9 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.4 GO:0016783 sulfurtransferase activity(GO:0016783)
0.0 0.3 GO:0031720 haptoglobin binding(GO:0031720)
0.0 0.5 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.3 GO:0004568 chitinase activity(GO:0004568)
0.0 0.6 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.2 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.0 0.4 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 0.2 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062) collagen receptor activity(GO:0038064)
0.0 0.4 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.0 0.4 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.3 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.7 GO:0016790 thiolester hydrolase activity(GO:0016790)
0.0 0.8 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 2.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.3 GO:0017002 activin-activated receptor activity(GO:0017002)
0.0 0.2 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0 1.1 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.1 GO:0043295 glutathione binding(GO:0043295)
0.0 1.4 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.1 GO:0070698 type I activin receptor binding(GO:0070698)
0.0 0.8 GO:0017022 myosin binding(GO:0017022)
0.0 0.8 GO:0044325 ion channel binding(GO:0044325)
0.0 0.3 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 0.2 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.1 GO:0017113 uracil binding(GO:0002058) pyrimidine nucleobase binding(GO:0002061) dihydropyrimidine dehydrogenase (NADP+) activity(GO:0017113)
0.0 0.7 GO:0071949 FAD binding(GO:0071949)
0.0 0.3 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.7 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.4 GO:0005548 phospholipid transporter activity(GO:0005548)
0.0 0.2 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.4 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.2 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 1.5 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 1.0 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 0.3 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.9 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 0.9 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.4 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.3 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.7 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 1.0 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.1 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.4 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.2 1.9 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.1 1.6 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 0.9 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 0.9 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.1 1.1 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 1.2 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.1 0.9 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 1.1 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 0.5 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 0.3 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 1.0 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 0.4 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.1 0.5 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.6 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.5 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 0.3 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.5 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.3 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.2 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.7 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 0.1 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 1.3 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 1.5 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.7 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.8 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.7 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 1.1 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.3 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.3 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.2 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.3 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 0.2 REACTOME TRAF6 MEDIATED NFKB ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.0 0.2 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease