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PRJEB1986: zebrafish developmental stages transcriptome

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Results for nkx3.3-1

Z-value: 1.10

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Transcription factors associated with nkx3.3-1

Gene Symbol Gene ID Gene Info
nkx3.3-1
ENSDARG00000110589 NK3 homeobox 3

Activity profile of nkx3.3-1 motif

Sorted Z-values of nkx3.3-1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr22_+_724639 2.92 ENSDART00000105323
zgc:162255
zgc:162255
chr19_-_35155722 2.10 ENSDART00000151924
macf1a
microtubule-actin crosslinking factor 1a
chr2_+_55916911 1.62 ENSDART00000189483
ENSDART00000183647
ENSDART00000083470
atcayb
ataxia, cerebellar, Cayman type b
chr24_-_33308045 1.57 ENSDART00000149711
slc4a2b
solute carrier family 4 (anion exchanger), member 2b
chr16_-_13612650 1.55 ENSDART00000080372
dbpb
D site albumin promoter binding protein b
chr23_+_36601984 1.50 ENSDART00000128598
igfbp6b
insulin-like growth factor binding protein 6b
chr25_+_28282274 1.49 ENSDART00000164502
aass
aminoadipate-semialdehyde synthase
chr2_+_39618951 1.48 ENSDART00000077108
zgc:136870
zgc:136870
chr7_-_23777445 1.48 ENSDART00000173527
si:ch211-200p22.4
si:ch211-200p22.4
chr22_+_7480465 1.45 ENSDART00000034545
CELA1 (1 of many)
zgc:92745
chr21_+_5589923 1.41 ENSDART00000160885
stbd1
starch binding domain 1
chr9_-_43073960 1.38 ENSDART00000059460
ttn.2
titin, tandem duplicate 2
chr20_-_53078607 1.33 ENSDART00000163494
ENSDART00000191730
CABZ01066813.1

chr5_+_2815021 1.31 ENSDART00000020472
hpda
4-hydroxyphenylpyruvate dioxygenase a
chr22_+_19188809 1.20 ENSDART00000134791
ENSDART00000133682
si:dkey-21e2.8
si:dkey-21e2.8
chr10_-_33343244 1.16 ENSDART00000164191
c2cd2
C2 calcium-dependent domain containing 2
chr1_-_54706039 1.15 ENSDART00000083633
exosc1
exosome component 1
chr19_+_43256986 1.12 ENSDART00000182336
DGKD
diacylglycerol kinase delta
chr19_+_8612839 1.11 ENSDART00000144925
snx27a
sorting nexin family member 27a
chr20_-_3911546 1.05 ENSDART00000169787
cnksr3
cnksr family member 3
chr10_+_25726694 1.02 ENSDART00000140308
ugt5d1
UDP glucuronosyltransferase 5 family, polypeptide D1
chr11_-_7050825 1.01 ENSDART00000179749
si:ch211-253b8.5
si:ch211-253b8.5
chr9_-_49531762 1.00 ENSDART00000121875
xirp2b
xin actin binding repeat containing 2b
chr7_-_5487593 0.99 ENSDART00000136594
arhgef11
Rho guanine nucleotide exchange factor (GEF) 11
chr16_-_22585289 0.99 ENSDART00000134239
ENSDART00000193959
ENSDART00000077998
si:dkey-238m4.3
cgna
si:dkey-238m4.3
cingulin a
chr9_-_7390388 0.99 ENSDART00000132392
slc23a3
solute carrier family 23, member 3
chr5_-_5243079 0.99 ENSDART00000130576
ENSDART00000164377
mvb12ba
multivesicular body subunit 12Ba
chr6_+_3280939 0.98 ENSDART00000151359
kdm4aa
lysine (K)-specific demethylase 4A, genome duplicate a
chr10_+_37268854 0.97 ENSDART00000131897
nf1b
neurofibromin 1b
chr7_-_32833153 0.96 ENSDART00000099871
ENSDART00000099872
slc17a6b
solute carrier family 17 (vesicular glutamate transporter), member 6b
chr16_+_38240027 0.95 ENSDART00000111081
prune
prune exopolyphosphatase
chr20_+_46741074 0.95 ENSDART00000145294
si:ch211-57i17.1
si:ch211-57i17.1
chr1_-_11075403 0.93 ENSDART00000102903
ENSDART00000170290
dmd
dystrophin
chr24_+_15670013 0.92 ENSDART00000185826
CU929414.1

chr8_-_51507144 0.92 ENSDART00000024882
ENSDART00000135166
fgfr1a
fibroblast growth factor receptor 1a
chr16_+_4658250 0.92 ENSDART00000006212
LIN28A
si:ch1073-284b18.2
chr21_-_28523548 0.92 ENSDART00000077910
epdl2
ependymin-like 2
chr8_+_8712446 0.91 ENSDART00000158674
elk1
ELK1, member of ETS oncogene family
chr19_-_6840506 0.89 ENSDART00000081568
tcf19l
transcription factor 19 (SC1), like
chr16_+_3982590 0.87 ENSDART00000149295
zc3h12a
zinc finger CCCH-type containing 12A
chr2_+_45593783 0.85 ENSDART00000148037
fndc7rs2
fibronectin type III domain containing 7, related sequence 2
chr12_-_9617770 0.84 ENSDART00000106267
arg1
arginase 1
chr5_-_57820873 0.83 ENSDART00000089961
sik2a
salt-inducible kinase 2a
chr5_-_57204352 0.82 ENSDART00000171252
ENSDART00000180727
man2a1
mannosidase, alpha, class 2A, member 1
chr18_+_26829362 0.82 ENSDART00000132728
slc28a1
solute carrier family 28 (concentrative nucleoside transporter), member 1
chr17_-_200316 0.81 ENSDART00000190561
CABZ01083778.1

chr4_-_12862087 0.80 ENSDART00000080536
hmga2
high mobility group AT-hook 2
chr17_-_16069905 0.80 ENSDART00000110383
map7a
microtubule-associated protein 7a
chr4_+_61995745 0.79 ENSDART00000171539
CT990567.1

chr22_-_20376488 0.79 ENSDART00000140187
zbtb7a
zinc finger and BTB domain containing 7a
chr1_-_50791280 0.78 ENSDART00000181224
CABZ01031870.1

chr21_+_26612777 0.78 ENSDART00000142667
esrra
estrogen-related receptor alpha
chr15_+_45595385 0.78 ENSDART00000161937
ENSDART00000170214
ENSDART00000157450
atg16l1
ATG16 autophagy related 16-like 1 (S. cerevisiae)
chr13_-_37109987 0.77 ENSDART00000136750
syne2b
spectrin repeat containing, nuclear envelope 2b
chr1_+_7988052 0.77 ENSDART00000167552
CR855320.2

chr8_+_25254435 0.76 ENSDART00000143554
ampd2b
adenosine monophosphate deaminase 2b
chr6_-_1820606 0.75 ENSDART00000183228
FO834857.1

chr19_+_7810028 0.73 ENSDART00000081592
ENSDART00000140719
aqp10b
aquaporin 10b
chr21_+_10021823 0.73 ENSDART00000163995
herc7
hect domain and RLD 7
chr10_+_5159475 0.71 ENSDART00000142507
cdc42se2
CDC42 small effector 2
chr4_-_8030583 0.70 ENSDART00000113628
si:ch211-240l19.8
si:ch211-240l19.8
chr21_-_2162850 0.69 ENSDART00000159731
gb:ai877918
expressed sequence AI877918
chr22_-_26236188 0.69 ENSDART00000162640
ENSDART00000167169
ENSDART00000138595
c3b.1
complement component c3b, tandem duplicate 1
chr4_-_71708567 0.68 ENSDART00000182645
si:dkeyp-4f2.1
si:dkeyp-4f2.1
chr2_+_42177113 0.68 ENSDART00000056441
tmeff1a
transmembrane protein with EGF-like and two follistatin-like domains 1a
chr9_-_27442339 0.67 ENSDART00000138602
stxbp5l
syntaxin binding protein 5-like
chr15_-_2973368 0.67 ENSDART00000163131
zgc:153184
zgc:153184
chr12_+_17754859 0.66 ENSDART00000112119
bhlha15
basic helix-loop-helix family, member a15
chr17_+_48164536 0.66 ENSDART00000161750
ENSDART00000156923
plekhd1
pleckstrin homology domain containing, family D (with coiled-coil domains) member 1
chr9_+_38074082 0.65 ENSDART00000017833
cacnb4a
calcium channel, voltage-dependent, beta 4a subunit
chr5_-_57655092 0.65 ENSDART00000074290
mia
melanoma inhibitory activity
chr16_-_26132122 0.65 ENSDART00000157787
lipeb
lipase, hormone-sensitive b
chr19_+_40248697 0.65 ENSDART00000151269
cdk6
cyclin-dependent kinase 6
chr8_-_51753604 0.64 ENSDART00000007090
tbx16
T-box 16
chr8_+_53051701 0.62 ENSDART00000131514
nadka
NAD kinase a
chr19_-_31402429 0.62 ENSDART00000137292
tmem106bb
transmembrane protein 106Bb
chr8_+_10869183 0.62 ENSDART00000188111
brpf3b
bromodomain and PHD finger containing, 3b
chr19_+_32321797 0.61 ENSDART00000167664
atxn1a
ataxin 1a
chr12_-_45304971 0.61 ENSDART00000186537
ENSDART00000126405
fdxr
ferredoxin reductase
chr22_+_35516440 0.61 ENSDART00000184191
hykk.2
hydroxylysine kinase, tandem duplicate 2
chr23_+_25172976 0.60 ENSDART00000140789
si:dkey-151g10.3
si:dkey-151g10.3
chr15_-_43873005 0.58 ENSDART00000190326
NOX4
NADPH oxidase 4
chr5_-_12063381 0.57 ENSDART00000026749
nipsnap1
nipsnap homolog 1 (C. elegans)
chr2_-_55903520 0.57 ENSDART00000128828
cplx4c
complexin 4c
chr6_-_35446110 0.57 ENSDART00000058773
rgs16
regulator of G protein signaling 16
chr12_+_18458502 0.57 ENSDART00000108745
rnf151
ring finger protein 151
chr20_-_33675676 0.56 ENSDART00000147168
rock2b
rho-associated, coiled-coil containing protein kinase 2b
chr14_+_26759332 0.56 ENSDART00000088484
ahnak
AHNAK nucleoprotein
chr10_+_34321492 0.55 ENSDART00000190523
stard13a
StAR-related lipid transfer (START) domain containing 13a
chr9_-_55586151 0.54 ENSDART00000181886
arsh
arylsulfatase H
chr21_+_5993188 0.54 ENSDART00000048399
slc4a4b
solute carrier family 4 (sodium bicarbonate cotransporter), member 4b
chr6_-_46398584 0.52 ENSDART00000193098
camk1a
calcium/calmodulin-dependent protein kinase Ia
chr15_+_2475894 0.51 ENSDART00000035939
panx1a
pannexin 1a
chr17_-_51262430 0.50 ENSDART00000163222
trappc12
trafficking protein particle complex 12
chr5_-_24124118 0.50 ENSDART00000051550
capga
capping protein (actin filament), gelsolin-like a
chr2_-_1569250 0.50 ENSDART00000167202
dab1b
Dab, reelin signal transducer, homolog 1b (Drosophila)
chr3_-_45298487 0.49 ENSDART00000102245
pdpk1a
3-phosphoinositide dependent protein kinase 1a
chr4_+_54973580 0.49 ENSDART00000162800
si:dkey-56m15.5
si:dkey-56m15.5
chr20_-_28698172 0.49 ENSDART00000190635
sipa1l1
signal-induced proliferation-associated 1 like 1
chr4_+_54583639 0.49 ENSDART00000190527
si:ch211-227e10.1
si:ch211-227e10.1
chr5_-_66702479 0.49 ENSDART00000129197
mn1b
meningioma 1b
chr25_+_10416583 0.48 ENSDART00000073907
ehf
ets homologous factor
chr3_-_34753605 0.46 ENSDART00000000160
thraa
thyroid hormone receptor alpha a
chr25_-_11016675 0.45 ENSDART00000099572
mespab
mesoderm posterior ab
chr18_-_33080454 0.45 ENSDART00000191907
v2ra18
vomeronasal 2 receptor, a18
chr5_+_30624183 0.45 ENSDART00000141444
abcg4a
ATP-binding cassette, sub-family G (WHITE), member 4a
chr2_+_28453338 0.44 ENSDART00000020456
mmp15b
matrix metallopeptidase 15b
chr15_+_46606090 0.44 ENSDART00000020921
CABZ01044048.1

chr19_+_9186175 0.44 ENSDART00000039325
hcn3
hyperpolarization activated cyclic nucleotide-gated potassium channel 3
chr15_+_5973909 0.42 ENSDART00000126886
ENSDART00000189618
igsf5b
immunoglobulin superfamily, member 5b
chr24_+_19863246 0.42 ENSDART00000165242
CU638714.1

chr4_-_30349370 0.42 ENSDART00000161790
znf1047
zinc finger protein 1047
chr5_+_26765275 0.41 ENSDART00000144169
si:ch211-102c2.8
si:ch211-102c2.8
chr22_-_34551568 0.41 ENSDART00000148147
rnf123
ring finger protein 123
chr9_-_53666031 0.41 ENSDART00000126314
pcdh8
protocadherin 8
chr25_+_33033633 0.41 ENSDART00000192336
tln2b
talin 2b
chr11_-_8782871 0.41 ENSDART00000158546
si:ch211-51h4.2
si:ch211-51h4.2
chr5_-_29122834 0.39 ENSDART00000087197
whrnb
whirlin b
chr4_-_14642379 0.39 ENSDART00000114977
si:ch211-127b11.1
si:ch211-127b11.1
chr14_+_21722235 0.38 ENSDART00000183667
stx3a
syntaxin 3A
chr22_-_16755885 0.38 ENSDART00000036467
patj
PATJ, crumbs cell polarity complex component
chr9_-_1604601 0.37 ENSDART00000143130
agps
alkylglycerone phosphate synthase
chr19_+_30990129 0.37 ENSDART00000052169
ENSDART00000193376
sync
syncoilin, intermediate filament protein
chr25_+_2361721 0.37 ENSDART00000172905
zmp:0000000932
zmp:0000000932
chr1_-_11519934 0.37 ENSDART00000162060
sdk1b
sidekick cell adhesion molecule 1b
chr8_-_8446430 0.36 ENSDART00000137382
cdk16
cyclin-dependent kinase 16
chr22_-_36750589 0.36 ENSDART00000010824
acy1
aminoacylase 1
chr7_-_37812176 0.36 ENSDART00000164485
adcy7
adenylate cyclase 7
chr19_+_42469058 0.36 ENSDART00000076915
si:dkey-166k12.1
si:dkey-166k12.1
chr1_-_35113974 0.35 ENSDART00000192811
ENSDART00000167461
BX897691.1

chr4_-_20521441 0.35 ENSDART00000066895
rassf8b
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8b
chr10_-_39052264 0.35 ENSDART00000144036
igsf5a
immunoglobulin superfamily, member 5a
chr17_-_7440397 0.35 ENSDART00000162597
grm1b
glutamate receptor, metabotropic 1b
chr23_-_26227805 0.32 ENSDART00000158082
BX927204.1

chr6_+_515181 0.31 ENSDART00000171374
CACNA1I (1 of many)
si:ch73-379f7.5
chr3_+_11926030 0.31 ENSDART00000081367
dnaja3a
DnaJ (Hsp40) homolog, subfamily A, member 3A
chr22_+_3914318 0.30 ENSDART00000188774
ENSDART00000082034
FO904903.1
Danio rerio major histocompatibility complex class I ULA (mhc1ula), mRNA.
chr4_+_11375894 0.30 ENSDART00000190471
ENSDART00000143963
pcloa
piccolo presynaptic cytomatrix protein a
chr23_-_46040618 0.30 ENSDART00000161415
CABZ01080918.1

chr21_+_34814444 0.29 ENSDART00000161816
wdr55
WD repeat domain 55
chr1_+_55643198 0.28 ENSDART00000060693
adgre7
adhesion G protein-coupled receptor E7
chr7_-_8022741 0.28 ENSDART00000172841
si:ch211-163c2.1
si:ch211-163c2.1
chr15_-_40041455 0.28 ENSDART00000099359
lpar5b
lysophosphatidic acid receptor 5b
chr1_-_46875493 0.28 ENSDART00000115081
agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr21_+_39948300 0.27 ENSDART00000137740
slc47a1
solute carrier family 47 (multidrug and toxin extrusion), member 1
chr19_+_791538 0.27 ENSDART00000146554
ENSDART00000138406
tmem79a
transmembrane protein 79a
chr21_-_14966718 0.27 ENSDART00000151200
mmp17a
matrix metallopeptidase 17a
chr15_+_47492838 0.26 ENSDART00000122372
sik3
SIK family kinase 3
chr6_-_59381391 0.26 ENSDART00000157066
ppp1r16b
protein phosphatase 1, regulatory subunit 16B
chr11_+_42556395 0.26 ENSDART00000039206
rps23
ribosomal protein S23
chr3_-_60886984 0.26 ENSDART00000170974
PITPNC1
phosphatidylinositol transfer protein, cytoplasmic 1
chr23_-_37432459 0.25 ENSDART00000188916
zmp:0000001088
zmp:0000001088
chr7_+_36467796 0.25 ENSDART00000146202
aktip
akt interacting protein
chr10_-_38456382 0.24 ENSDART00000182129
gdpd5a
glycerophosphodiester phosphodiesterase domain containing 5a
chr15_-_42736433 0.24 ENSDART00000154379
si:ch211-181d7.1
si:ch211-181d7.1
chr24_-_21404367 0.24 ENSDART00000152093
atp8a2
ATPase phospholipid transporting 8A2
chr7_-_52842605 0.24 ENSDART00000083002
map1aa
microtubule-associated protein 1Aa
chr16_+_46725087 0.24 ENSDART00000008920
rab11al
RAB11a, member RAS oncogene family, like
chr22_+_38159823 0.23 ENSDART00000104527
tm4sf18
transmembrane 4 L six family member 18
chr5_-_29122615 0.23 ENSDART00000144802
whrnb
whirlin b
chr20_+_23498255 0.23 ENSDART00000149922
palld
palladin, cytoskeletal associated protein
chr2_+_30463825 0.23 ENSDART00000092356
neto1
neuropilin (NRP) and tolloid (TLL)-like 1
chr22_-_36770649 0.23 ENSDART00000169442
acy1
aminoacylase 1
chr12_+_2381213 0.23 ENSDART00000188007
LO018238.1

chr23_-_21946603 0.23 ENSDART00000148120
ENSDART00000184524
ephb2a
eph receptor B2a
chr4_-_75982054 0.23 ENSDART00000168369
si:ch211-232d10.1
si:ch211-232d10.1
chr15_-_12319065 0.23 ENSDART00000162973
ENSDART00000170543
fxyd6
FXYD domain containing ion transport regulator 6
chr19_-_9867001 0.22 ENSDART00000091695
cacng7a
calcium channel, voltage-dependent, gamma subunit 7a
chr25_-_19666107 0.22 ENSDART00000149889
atp2b1b
ATPase plasma membrane Ca2+ transporting 1b
chr23_-_39959784 0.22 ENSDART00000115046
xcr1a.1
chemokine (C motif) receptor 1a, duplicate 1
chr12_-_44016898 0.22 ENSDART00000175304
si:dkey-201i2.4
si:dkey-201i2.4
chr23_-_29812667 0.22 ENSDART00000006120
pik3cd
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
chr8_-_18229169 0.22 ENSDART00000131764
ENSDART00000143036
ENSDART00000145986
si:ch211-241d21.5
si:ch211-241d21.5
chr14_-_31814149 0.21 ENSDART00000173393
arhgef6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr2_-_57918314 0.21 ENSDART00000138265
si:dkeyp-68b7.7
si:dkeyp-68b7.7
chr19_-_29302249 0.21 ENSDART00000188751
srfbp1
serum response factor binding protein 1
chr5_+_57726425 0.21 ENSDART00000134684
fdxacb1
ferredoxin-fold anticodon binding domain containing 1
chr24_-_11057305 0.21 ENSDART00000186494
asap1b
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1b
chr17_-_22324727 0.21 ENSDART00000160341
CU104709.1

chr6_+_13606410 0.20 ENSDART00000104716
asic4b
acid-sensing (proton-gated) ion channel family member 4b
chr1_+_56779495 0.20 ENSDART00000192871
FO680692.1

chr16_+_27444098 0.20 ENSDART00000157690
invs
inversin
chr7_-_35083585 0.20 ENSDART00000192732
agrp
agouti related neuropeptide
chr14_-_36763302 0.19 ENSDART00000074786
ctso
cathepsin O
chr22_+_16022211 0.19 ENSDART00000062618
serpinc1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr5_-_23855447 0.19 ENSDART00000051541
gbgt1l3
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, like 3
chr3_-_32603191 0.19 ENSDART00000150997
si:ch73-248e21.7
si:ch73-248e21.7
chr9_+_51655636 0.19 ENSDART00000169908
RBMS1 (1 of many)
RNA binding motif single stranded interacting protein 1
chr8_-_54223316 0.18 ENSDART00000018054
trh
thyrotropin-releasing hormone
chr11_+_24620742 0.18 ENSDART00000182471
ENSDART00000048365
syt6b
synaptotagmin VIb
chr5_-_38248347 0.18 ENSDART00000084917
ENSDART00000139479
slc12a9
solute carrier family 12, member 9
chr19_+_42470396 0.18 ENSDART00000191679
si:dkey-166k12.1
si:dkey-166k12.1
chr16_-_14332561 0.18 ENSDART00000186784
ENSDART00000011224
itga10
integrin, alpha 10
chr23_-_17003533 0.18 ENSDART00000080545
dnmt3bb.2
DNA (cytosine-5-)-methyltransferase 3 beta, duplicate b.2
chr16_+_20934353 0.18 ENSDART00000052660
skap2
src kinase associated phosphoprotein 2
chr18_+_13182528 0.16 ENSDART00000166298
zgc:56622
zgc:56622
chr5_+_5689476 0.16 ENSDART00000022729
unm_sa808
un-named sa808
chr21_+_18877130 0.16 ENSDART00000136893
si:dkey-65l23.2
si:dkey-65l23.2
chr14_+_25817628 0.16 ENSDART00000047680
glra1
glycine receptor, alpha 1
chr18_+_2593756 0.16 ENSDART00000158022
p2ry2.3
purinergic receptor P2Y2, tandem duplicate 3

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx3.3-1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0033512 lysine biosynthetic process(GO:0009085) lysine biosynthetic process via aminoadipic acid(GO:0019878) L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512)
0.4 2.9 GO:0031063 regulation of histone deacetylation(GO:0031063)
0.3 2.1 GO:0060832 oocyte animal/vegetal axis specification(GO:0060832)
0.3 0.9 GO:1900274 positive regulation of phospholipase C activity(GO:0010863) regulation of phospholipase C activity(GO:1900274)
0.2 1.0 GO:0019068 virion assembly(GO:0019068) virus maturation(GO:0019075) multi-organism membrane organization(GO:0044803) viral budding(GO:0046755) multi-organism organelle organization(GO:1902590) multi-organism membrane budding(GO:1902592)
0.2 2.6 GO:0006798 polyphosphate metabolic process(GO:0006797) polyphosphate catabolic process(GO:0006798)
0.2 1.3 GO:0006572 tyrosine catabolic process(GO:0006572)
0.2 0.9 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.2 0.6 GO:0048389 paraxial mesoderm morphogenesis(GO:0048340) paraxial mesoderm formation(GO:0048341) intermediate mesoderm development(GO:0048389)
0.2 1.0 GO:0060251 regulation of glial cell proliferation(GO:0060251)
0.2 0.8 GO:0039689 viral genome replication(GO:0019079) negative stranded viral RNA replication(GO:0039689) viral RNA genome replication(GO:0039694) RNA replication(GO:0039703) multi-organism biosynthetic process(GO:0044034)
0.1 0.8 GO:0006013 mannose metabolic process(GO:0006013)
0.1 1.5 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.1 0.4 GO:0046504 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) cellular lipid biosynthetic process(GO:0097384) ether biosynthetic process(GO:1901503)
0.1 1.0 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.1 0.8 GO:0000050 urea cycle(GO:0000050) urea metabolic process(GO:0019627)
0.1 2.1 GO:0015701 bicarbonate transport(GO:0015701)
0.1 0.7 GO:0006833 water transport(GO:0006833)
0.1 0.6 GO:0006741 NADP biosynthetic process(GO:0006741)
0.1 1.4 GO:0048769 sarcomerogenesis(GO:0048769)
0.1 0.8 GO:0007525 somatic muscle development(GO:0007525)
0.1 0.4 GO:0098881 exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
0.1 0.5 GO:0032732 positive regulation of interleukin-1 production(GO:0032732)
0.1 0.6 GO:0043696 dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697)
0.1 0.2 GO:2000257 regulation of protein activation cascade(GO:2000257)
0.1 0.5 GO:0097476 spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477)
0.1 0.2 GO:1903792 histamine metabolic process(GO:0001692) negative regulation of anion transport(GO:1903792)
0.1 0.8 GO:1901642 nucleoside transport(GO:0015858) nucleoside transmembrane transport(GO:1901642)
0.1 0.8 GO:0032264 IMP salvage(GO:0032264)
0.1 0.2 GO:0071361 cellular response to ethanol(GO:0071361)
0.1 0.2 GO:0072003 kidney rudiment formation(GO:0072003) pronephros formation(GO:0072116)
0.0 1.5 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.0 0.5 GO:0002154 thyroid hormone mediated signaling pathway(GO:0002154)
0.0 1.1 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.0 0.6 GO:0044154 histone H3-K14 acetylation(GO:0044154)
0.0 0.4 GO:0034334 adherens junction maintenance(GO:0034334)
0.0 0.3 GO:0060465 pharynx development(GO:0060465)
0.0 0.4 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.2 GO:0070257 regulation of mucus secretion(GO:0070255) positive regulation of mucus secretion(GO:0070257)
0.0 0.4 GO:0031295 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0 0.6 GO:0019433 triglyceride catabolic process(GO:0019433)
0.0 0.6 GO:2000651 positive regulation of sodium ion transport(GO:0010765) positive regulation of sodium ion transmembrane transport(GO:1902307) regulation of potassium ion import(GO:1903286) positive regulation of potassium ion import(GO:1903288) positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.0 1.6 GO:0003351 epithelial cilium movement(GO:0003351)
0.0 0.6 GO:0032418 lysosome localization(GO:0032418)
0.0 0.3 GO:0035188 hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.0 0.2 GO:0032776 DNA methylation on cytosine(GO:0032776)
0.0 0.1 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171) Schwann cell migration(GO:0036135) cardiac neuron differentiation(GO:0060945) cardiac neuron development(GO:0060959)
0.0 0.6 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.0 0.6 GO:1901663 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 0.3 GO:1904071 presynaptic active zone assembly(GO:1904071)
0.0 0.5 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
0.0 0.2 GO:2000253 adult feeding behavior(GO:0008343) positive regulation of feeding behavior(GO:2000253)
0.0 0.8 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.2 GO:0031048 chromatin silencing by small RNA(GO:0031048)
0.0 0.2 GO:0070475 rRNA base methylation(GO:0070475)
0.0 0.8 GO:0061035 regulation of cartilage development(GO:0061035)
0.0 0.2 GO:0098927 early endosome to late endosome transport(GO:0045022) vesicle-mediated transport between endosomal compartments(GO:0098927)
0.0 0.7 GO:0050708 regulation of protein secretion(GO:0050708)
0.0 0.1 GO:0032096 negative regulation of response to food(GO:0032096) negative regulation of appetite(GO:0032099)
0.0 0.7 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 0.5 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
0.0 0.2 GO:0048669 collateral sprouting in absence of injury(GO:0048669) regulation of collateral sprouting in absence of injury(GO:0048696)
0.0 0.2 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.0 0.1 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
0.0 0.3 GO:0009408 response to heat(GO:0009408)
0.0 1.0 GO:0006469 negative regulation of protein kinase activity(GO:0006469)
0.0 1.2 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 0.2 GO:0030259 lipid glycosylation(GO:0030259)
0.0 0.7 GO:0031017 exocrine pancreas development(GO:0031017) exocrine system development(GO:0035272)
0.0 0.7 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 0.2 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 0.3 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.1 GO:0032019 mitochondrial cloud(GO:0032019)
0.1 1.5 GO:0098894 presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) extrinsic component of presynaptic membrane(GO:0098888) extrinsic component of presynaptic endocytic zone(GO:0098894)
0.1 0.6 GO:0043034 costamere(GO:0043034)
0.1 1.1 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.1 0.6 GO:0032426 stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142) stereocilium tip(GO:0032426)
0.1 1.0 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.2 GO:0070695 FHF complex(GO:0070695)
0.0 2.1 GO:0030496 midbody(GO:0030496)
0.0 0.8 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.6 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.5 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.3 GO:0098982 GABA-ergic synapse(GO:0098982)
0.0 0.8 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.6 GO:0043195 terminal bouton(GO:0043195)
0.0 1.6 GO:0031902 late endosome membrane(GO:0031902)
0.0 0.5 GO:0005921 gap junction(GO:0005921)
0.0 2.1 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.4 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 1.4 GO:0005814 centriole(GO:0005814)
0.0 0.1 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.3 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.6 GO:0044853 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.0 0.6 GO:0099634 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.0 0.7 GO:0031201 SNARE complex(GO:0031201)
0.0 0.2 GO:0002178 palmitoyltransferase complex(GO:0002178)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0003868 4-hydroxyphenylpyruvate dioxygenase activity(GO:0003868)
0.3 1.4 GO:2001070 starch binding(GO:2001070)
0.2 2.6 GO:0004309 exopolyphosphatase activity(GO:0004309)
0.1 1.5 GO:0031994 insulin-like growth factor I binding(GO:0031994) insulin-like growth factor II binding(GO:0031995)
0.1 1.5 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 0.6 GO:0019202 amino acid kinase activity(GO:0019202)
0.1 0.5 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.1 2.1 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.1 0.8 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.1 0.7 GO:0015168 glycerol transmembrane transporter activity(GO:0015168)
0.1 1.0 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 1.0 GO:0005326 neurotransmitter transporter activity(GO:0005326)
0.1 0.9 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.1 0.6 GO:0072518 Rho-dependent protein serine/threonine kinase activity(GO:0072518)
0.1 0.2 GO:0016436 rRNA (uridine) methyltransferase activity(GO:0016436)
0.1 1.0 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1 0.8 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1 0.3 GO:0017020 myosin phosphatase regulator activity(GO:0017020)
0.1 0.6 GO:0004046 aminoacylase activity(GO:0004046)
0.1 1.5 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.1 0.8 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.1 0.2 GO:0031781 type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.0 0.3 GO:0099530 G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.0 1.4 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.6 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.6 GO:0010484 H3 histone acetyltransferase activity(GO:0010484) histone acetyltransferase activity (H3-K23 specific)(GO:0043994)
0.0 0.7 GO:0045159 myosin II binding(GO:0045159)
0.0 0.6 GO:0019870 chloride channel inhibitor activity(GO:0019869) potassium channel inhibitor activity(GO:0019870)
0.0 1.1 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.2 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 0.2 GO:0035197 siRNA binding(GO:0035197)
0.0 0.1 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.0 0.1 GO:0030626 U12 snRNA binding(GO:0030626)
0.0 0.5 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.7 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.3 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.3 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.2 GO:0052812 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
0.0 0.3 GO:0042910 xenobiotic transporter activity(GO:0042910)
0.0 1.0 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.2 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.6 GO:0003951 NAD+ kinase activity(GO:0003951)
0.0 0.2 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.3 GO:0098882 structural constituent of presynaptic active zone(GO:0098882)
0.0 0.2 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.2 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.4 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 0.4 GO:0005272 sodium channel activity(GO:0005272)
0.0 0.5 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.6 GO:0015370 solute:sodium symporter activity(GO:0015370)
0.0 0.3 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.2 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.2 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.1 0.2 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 1.1 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.0 0.8 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 1.0 ST GA13 PATHWAY G alpha 13 Pathway
0.0 0.4 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.6 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.3 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 0.2 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.6 PID PTP1B PATHWAY Signaling events mediated by PTP1B

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.1 1.0 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.5 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 1.1 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.9 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 0.4 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.8 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 0.2 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.8 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.3 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.4 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.6 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.2 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.2 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.1 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 2.3 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.3 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.2 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.3 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction