ISMARA results: nr3c1

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PRJEB1986: zebrafish developmental stages transcriptome

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Results for nr3c1_ar

Z-value: 2.35

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Transcription factors associated with nr3c1_ar

Gene Symbol	Gene ID	Gene Info
nr3c1 NCBI UniProt	ENSDARG00000025032	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
nr3c1 NCBI UniProt	ENSDARG00000112480	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
nr3c1 NCBI UniProt	ENSDARG00000116957	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
ar NCBI UniProt	ENSDARG00000067976	androgen receptor
ar NCBI UniProt	ENSDARG00000114287	androgen receptor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
nr3c1	dr11_v1_chr14_-_23801389_23801389	-0.85	4.0e-06	Click!
ar	dr11_v1_chr5_+_35561607_35561607	0.51	2.4e-02	Click!

Activity profile of nr3c1_ar motif

Sorted Z-values of nr3c1_ar motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr6_+_41096058 Show fit	17.94	ENSDART00000028373	fkbp5 NCBI UniProt Show fit	FK506 binding protein 5
chr6_+_41099787 Show fit	12.86	ENSDART00000186884	fkbp5 NCBI UniProt Show fit	FK506 binding protein 5
chr12_+_13256415 Show fit	12.41	ENSDART00000144542	atp2a1l NCBI UniProt Show fit	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, like
chr3_-_31079186 Show fit	10.83	ENSDART00000145636 ENSDART00000140569	ELOB (1 of many) NCBI UniProt Show fit elob NCBI UniProt Show fit	elongin B elongin B
chr17_-_37395460 Show fit	10.20	ENSDART00000148160 ENSDART00000075975	crip1 NCBI UniProt Show fit	cysteine-rich protein 1
chr16_+_50089417 Show fit	7.98	ENSDART00000153675	nr1d2a NCBI UniProt Show fit	nuclear receptor subfamily 1, group D, member 2a
chr24_-_38097305 Show fit	7.78	ENSDART00000124321	crp2 NCBI UniProt Show fit	C-reactive protein 2
chr6_-_46875310 Show fit	7.66	ENSDART00000154442	igfn1.3 NCBI UniProt Show fit	immunoglobulin-like and fibronectin type III domain containing 1, tandem duplicate 3
chr5_-_24238733 Show fit	5.94	ENSDART00000138170	plscr3a NCBI UniProt Show fit	phospholipid scramblase 3a
chr15_-_9031996 Show fit	5.91	ENSDART00000124998	rtn2a NCBI UniProt Show fit	reticulon 2a

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of nr3c1_ar

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	30.8	GO:0000413	protein peptidyl-prolyl isomerization(GO:0000413)
0.1	22.3	GO:0070588	calcium ion transmembrane transport(GO:0070588)
0.6	12.3	GO:0030007	cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.2	11.0	GO:0032922	circadian regulation of gene expression(GO:0032922)
0.2	10.3	GO:0006368	transcription elongation from RNA polymerase II promoter(GO:0006368)
3.4	10.2	GO:0071236	cellular response to antibiotic(GO:0071236) cellular response to toxic substance(GO:0097237)
0.0	9.6	GO:0007601	visual perception(GO:0007601)
0.4	8.5	GO:0006825	copper ion transport(GO:0006825)
0.0	8.1	GO:0009617	response to bacterium(GO:0009617)
1.3	8.0	GO:0006545	glycine biosynthetic process(GO:0006545)

Showing 1 to 10 of 131 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	13.8	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
1.8	10.8	GO:0030891	VCB complex(GO:0030891)
0.1	10.6	GO:0005777	peroxisome(GO:0005777) microbody(GO:0042579)
0.2	8.9	GO:0031970	mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.1	8.4	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.0	7.3	GO:0031012	extracellular matrix(GO:0031012)
0.2	6.7	GO:0031594	neuromuscular junction(GO:0031594)
0.6	4.8	GO:0033165	interphotoreceptor matrix(GO:0033165)
0.1	4.7	GO:0016342	catenin complex(GO:0016342)
0.0	4.7	GO:0043025	neuronal cell body(GO:0043025)

Showing 1 to 10 of 58 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
7.7	30.8	GO:0005528	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.3	16.7	GO:0015020	glucuronosyltransferase activity(GO:0015020)
0.7	12.4	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
1.1	10.9	GO:0005391	sodium:potassium-exchanging ATPase activity(GO:0005391)
0.2	10.0	GO:0015485	cholesterol binding(GO:0015485)
0.1	9.4	GO:0008201	heparin binding(GO:0008201)
1.7	8.5	GO:0016531	copper chaperone activity(GO:0016531)
0.3	8.4	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
0.3	8.2	GO:0008483	transaminase activity(GO:0008483)
0.0	8.2	GO:0042277	peptide binding(GO:0042277)

Showing 1 to 10 of 116 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	31.6	PID REG GR PATHWAY	Glucocorticoid receptor regulatory network
0.5	3.9	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.1	3.3	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.3	3.0	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	2.9	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.1	2.5	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.2	2.3	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.0	1.5	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.1	1.2	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.0	0.7	SIG CD40PATHWAYMAP	Genes related to CD40 signaling

Showing 1 to 10 of 15 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	3.5	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.1	3.0	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.1	2.8	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.0	2.7	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
0.1	2.6	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.2	2.5	REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE	Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.2	2.0	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators
0.1	2.0	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.1	1.6	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	1.6	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides

Showing 1 to 10 of 21 entries

Results for nr3c1_ar

Z-value: 2.35

Motif logo

Transcription factors associated with nr3c1_ar

Activity-expression correlation:

Activity profile of nr3c1_ar motif

Sorted Z-values of nr3c1_ar motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of nr3c1_ar

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: