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PRJEB1986: zebrafish developmental stages transcriptome
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Results for nr5a1a+nr5a2+nr5a5
Z-value: 2.70
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Transcription factors associated with nr5a1a+nr5a2+nr5a5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| nr5a5 | dr11_v1_chr3_-_53465223_53465249 | 0.71 | 6.0e-04 | Click! |
| nr5a2 | dr11_v1_chr22_-_22719440_22719440 | 0.50 | 3.0e-02 | Click! |
| nr5a1a | dr11_v1_chr8_-_52871056_52871056 | 0.46 | 4.8e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of nr5a1a+nr5a2+nr5a5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 25.5 | GO:0007601 | visual perception(GO:0007601) |
| 4.5 | 18.0 | GO:2000392 | lamellipodium morphogenesis(GO:0072673) regulation of lamellipodium morphogenesis(GO:2000392) |
| 2.8 | 16.5 | GO:0006699 | bile acid biosynthetic process(GO:0006699) bile acid metabolic process(GO:0008206) |
| 0.1 | 12.5 | GO:0070588 | calcium ion transmembrane transport(GO:0070588) |
| 1.1 | 11.3 | GO:0032024 | positive regulation of insulin secretion(GO:0032024) |
| 0.2 | 11.3 | GO:0018298 | protein-chromophore linkage(GO:0018298) |
| 0.1 | 8.8 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.6 | 8.5 | GO:0045162 | clustering of voltage-gated sodium channels(GO:0045162) |
| 0.6 | 8.4 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.7 | 7.2 | GO:0000305 | response to superoxide(GO:0000303) response to oxygen radical(GO:0000305) removal of superoxide radicals(GO:0019430) cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451) cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 47.7 | GO:0005576 | extracellular region(GO:0005576) |
| 0.0 | 25.8 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 3.6 | 18.0 | GO:0032433 | filopodium tip(GO:0032433) |
| 0.0 | 17.0 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.1 | 13.4 | GO:0000786 | nucleosome(GO:0000786) |
| 0.2 | 11.3 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.8 | 9.1 | GO:0045095 | keratin filament(GO:0045095) |
| 0.1 | 9.0 | GO:0005746 | mitochondrial respiratory chain(GO:0005746) |
| 0.5 | 8.8 | GO:0043209 | myelin sheath(GO:0043209) |
| 1.4 | 8.5 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 18.0 | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) |
| 0.3 | 17.5 | GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) |
| 0.1 | 16.6 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 2.6 | 15.3 | GO:0032052 | bile acid binding(GO:0032052) |
| 0.5 | 13.4 | GO:0016676 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.2 | 12.9 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 1.9 | 11.3 | GO:0005536 | glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) glucose binding(GO:0005536) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158) |
| 0.2 | 11.3 | GO:0008020 | G-protein coupled photoreceptor activity(GO:0008020) |
| 1.6 | 11.1 | GO:0004459 | L-lactate dehydrogenase activity(GO:0004459) |
| 0.6 | 8.8 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 13.6 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.4 | 6.6 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.2 | 4.9 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.2 | 3.1 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.1 | 3.0 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.2 | 2.6 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.1 | 2.5 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.1 | 2.3 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 1.6 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 16.5 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| 1.9 | 13.4 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 11.2 | REACTOME POTASSIUM CHANNELS | Genes involved in Potassium Channels |
| 0.5 | 10.3 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.0 | 3.9 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.1 | 3.8 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 3.4 | REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 0.3 | 3.1 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.2 | 2.9 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.1 | 2.7 | REACTOME TRIGLYCERIDE BIOSYNTHESIS | Genes involved in Triglyceride Biosynthesis |