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PRJEB1986: zebrafish developmental stages transcriptome

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Results for pax8

Z-value: 0.50

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Transcription factors associated with pax8

Gene Symbol Gene ID Gene Info
pax8
ENSDARG00000015879 paired box 8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
pax8dr11_v1_chr5_-_72415578_724155780.399.6e-02Click!

Activity profile of pax8 motif

Sorted Z-values of pax8 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_25630555 1.58 ENSDART00000133425
acot15
acyl-CoA thioesterase 15
chr20_-_9436521 0.99 ENSDART00000133000
zgc:101840
zgc:101840
chr16_+_23487051 0.92 ENSDART00000145496
icn2
ictacalcin 2
chr7_+_10610791 0.65 ENSDART00000166064
fah
fumarylacetoacetate hydrolase (fumarylacetoacetase)
chr25_-_7520937 0.64 ENSDART00000170050
cdkn1cb
cyclin-dependent kinase inhibitor 1Cb
chr16_+_49601838 0.57 ENSDART00000168570
ENSDART00000159236
si:dkey-82o10.4
si:dkey-82o10.4
chr10_+_36037977 0.48 ENSDART00000164678
katnal1
katanin p60 subunit A-like 1
chr22_-_25033105 0.47 ENSDART00000124220
nptxrb
neuronal pentraxin receptor b
chr2_-_985417 0.47 ENSDART00000140540
si:ch211-241e1.3
si:ch211-241e1.3
chr24_-_25442342 0.47 ENSDART00000177140
ENSDART00000138215
phex
phosphate regulating endopeptidase homolog, X-linked
chr16_+_43347966 0.45 ENSDART00000171308
zmp:0000000930
zmp:0000000930
chr20_+_10498986 0.42 ENSDART00000064114
zgc:100997
zgc:100997
chr20_-_14680897 0.41 ENSDART00000063857
ENSDART00000161314
scrn2
secernin 2
chr9_+_17348745 0.39 ENSDART00000147488
slain1a
SLAIN motif family, member 1a
chr22_-_16412496 0.39 ENSDART00000137497
cts12
cathepsin 12
chr9_+_39027123 0.37 ENSDART00000004742
cps1
carbamoyl-phosphate synthase 1, mitochondrial
chr9_+_39027312 0.36 ENSDART00000192258
ENSDART00000164407
cps1
carbamoyl-phosphate synthase 1, mitochondrial
chr15_+_16387088 0.36 ENSDART00000101789
flot2b
flotillin 2b
chr15_+_638457 0.34 ENSDART00000157162
znf1013
zinc finger protein 1013
chr20_+_10498704 0.33 ENSDART00000192985
zgc:100997
zgc:100997
chr25_+_18475032 0.33 ENSDART00000073564
tes
testis derived transcript (3 LIM domains)
chr22_+_18929412 0.33 ENSDART00000161598
ENSDART00000166650
ENSDART00000015951
ENSDART00000105392
ENSDART00000131131
bsg
basigin
chr3_+_46444625 0.31 ENSDART00000108686
si:ch211-66e2.3
si:ch211-66e2.3
chr9_-_25425381 0.31 ENSDART00000129522
acvr2aa
activin A receptor type 2Aa
chr9_+_43797902 0.30 ENSDART00000020550
ube2e3
ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)
chr7_+_20019125 0.30 ENSDART00000186391
bcl6b
B-cell CLL/lymphoma 6, member B
chr3_+_46444999 0.27 ENSDART00000186530
si:ch211-66e2.3
si:ch211-66e2.3
chr7_-_8981507 0.26 ENSDART00000161422
si:ch211-183d5.2
si:ch211-183d5.2
chr10_-_40352250 0.25 ENSDART00000150821
taar20f
trace amine associated receptor 20f
chr15_-_33734105 0.25 ENSDART00000172729
ENSDART00000172045
trmt9b
tRNA methyltransferase 9B
chr3_-_16110351 0.24 ENSDART00000064838
lasp1
LIM and SH3 protein 1
chr24_+_31334209 0.22 ENSDART00000168837
ENSDART00000172473
fam168b
family with sequence similarity 168, member B
chr18_-_19004247 0.22 ENSDART00000135800
ints14
integrator complex subunit 14
chr1_+_51721851 0.22 ENSDART00000040397
prdx2
peroxiredoxin 2
chr23_+_26733232 0.22 ENSDART00000035080
zgc:158263
zgc:158263
chr9_-_21825913 0.21 ENSDART00000101986
mrpl30
mitochondrial ribosomal protein L30
chr23_+_43255328 0.20 ENSDART00000102712
tgm2a
transglutaminase 2, C polypeptide A
chr20_+_15164482 0.20 ENSDART00000181842
ENSDART00000063877
prdx6
peroxiredoxin 6
chr23_-_24699400 0.20 ENSDART00000104031
sdf4
stromal cell derived factor 4
chr23_+_32039386 0.19 ENSDART00000133801
mylk2
myosin light chain kinase 2
chr3_-_16110100 0.19 ENSDART00000051807
lasp1
LIM and SH3 protein 1
chr7_-_73843720 0.19 ENSDART00000111622
caap1
caspase activity and apoptosis inhibitor 1
chr16_-_34195002 0.17 ENSDART00000054026
rcc1
regulator of chromosome condensation 1
chr9_+_35014728 0.17 ENSDART00000100700
gabpa
GA binding protein transcription factor, alpha subunit
chr24_-_21973163 0.17 ENSDART00000131406
acot9.1
acyl-CoA thioesterase 9, tandem duplicate 1
chr6_+_25215944 0.17 ENSDART00000165456
si:ch73-97h19.2
si:ch73-97h19.2
chr5_+_68826514 0.16 ENSDART00000061406
usp39
ubiquitin specific peptidase 39
chr4_-_17803784 0.16 ENSDART00000187195
spi2
Spi-2 proto-oncogene
chr20_+_35445462 0.16 ENSDART00000124497
tdrd6
tudor domain containing 6
chr22_-_16154771 0.15 ENSDART00000009464
slc30a7
solute carrier family 30 (zinc transporter), member 7
chr7_-_29356084 0.15 ENSDART00000075757
gtf2a2
general transcription factor IIA, 2
chr11_-_165288 0.15 ENSDART00000108703
ENSDART00000173151
tegt
testis enhanced gene transcript (BAX inhibitor 1)
chr16_+_41135018 0.14 ENSDART00000139435
si:ch211-53m15.2
si:ch211-53m15.2
chr10_+_24660225 0.14 ENSDART00000190695
vps36
vacuolar protein sorting 36 homolog (S. cerevisiae)
chr5_-_35888499 0.14 ENSDART00000193932
rxfp2l
relaxin/insulin-like family peptide receptor 2, like
chr5_+_4298636 0.14 ENSDART00000100061
prdx4
peroxiredoxin 4
chr1_+_55239710 0.14 ENSDART00000174846
si:ch211-286b5.2
si:ch211-286b5.2
chr6_-_436658 0.13 ENSDART00000191515
grap2b
GRB2-related adaptor protein 2b
chr24_-_36727922 0.12 ENSDART00000135142
si:ch73-334d15.1
si:ch73-334d15.1
chr24_-_21973365 0.12 ENSDART00000081204
ENSDART00000030592
acot9.1
acyl-CoA thioesterase 9, tandem duplicate 1
chr10_+_40598791 0.11 ENSDART00000131895
taar17a
trace amine associated receptor 17a
chr22_-_31752937 0.11 ENSDART00000169611
CABZ01028298.1

chr10_+_24660017 0.10 ENSDART00000079597
vps36
vacuolar protein sorting 36 homolog (S. cerevisiae)
chr20_+_32224405 0.10 ENSDART00000062993
ENSDART00000147448
sesn1
sestrin 1
chr25_+_10834903 0.10 ENSDART00000155247
si:ch211-147g22.5
si:ch211-147g22.5
chr7_+_19374683 0.10 ENSDART00000162700
snrpf
small nuclear ribonucleoprotein polypeptide F
chr7_+_3444473 0.09 ENSDART00000122334
si:ch211-285c6.2
si:ch211-285c6.2
chr23_+_44049509 0.09 ENSDART00000102003
txk
TXK tyrosine kinase
chr10_+_29770120 0.09 ENSDART00000100032
ENSDART00000193205
hyou1
hypoxia up-regulated 1
chr22_+_4447387 0.09 ENSDART00000189742
ENSDART00000166768
timm44
translocase of inner mitochondrial membrane 44 homolog (yeast)
chr6_-_10927766 0.09 ENSDART00000134327
ccr7
chemokine (C-C motif) receptor 7
chr1_+_9966384 0.08 ENSDART00000132607
si:dkeyp-75b4.8
si:dkeyp-75b4.8
chr16_-_11986321 0.08 ENSDART00000148666
ENSDART00000029121
usp5
ubiquitin specific peptidase 5 (isopeptidase T)
chr6_-_130849 0.07 ENSDART00000108710
LRRC8E
si:zfos-323e3.4
chr5_+_23630384 0.07 ENSDART00000013745
cx39.9
connexin 39.9
chr14_+_48062180 0.07 ENSDART00000056713
ppid
peptidylprolyl isomerase D
chr15_-_34892664 0.07 ENSDART00000153787
ENSDART00000099721
rnf183
ring finger protein 183
chr17_-_33405301 0.06 ENSDART00000157089
BX323819.1

chr16_-_43011470 0.06 ENSDART00000131898
ENSDART00000142003
ENSDART00000017966
nudt17
nudix (nucleoside diphosphate linked moiety X)-type motif 17
chr5_-_37341044 0.06 ENSDART00000084675
wdr44
WD repeat domain 44
chr20_+_36234335 0.06 ENSDART00000193484
ENSDART00000181664
cnih3
cornichon family AMPA receptor auxiliary protein 3
chr22_+_2598998 0.05 ENSDART00000176665
CU570894.1

chr4_-_30528239 0.05 ENSDART00000169290
znf1052
zinc finger protein 1052
chr5_-_27438812 0.03 ENSDART00000078755
drd7
dopamine receptor D7
chr4_-_39265279 0.02 ENSDART00000164912
si:ch73-236c18.2
si:ch73-236c18.2
chr14_-_32491127 0.02 ENSDART00000186724
mcf2a
MCF.2 cell line derived transforming sequence a
chr19_+_46372115 0.02 ENSDART00000163935
med30
mediator complex subunit 30
chr4_+_36489448 0.01 ENSDART00000143181
znf1149
zinc finger protein 1149

Network of associatons between targets according to the STRING database.

First level regulatory network of pax8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0097272 ammonia homeostasis(GO:0097272)
0.1 0.6 GO:0032979 protein insertion into membrane from inner side(GO:0032978) protein insertion into mitochondrial membrane from inner side(GO:0032979) protein insertion into mitochondrial membrane(GO:0051204)
0.1 0.4 GO:0035994 response to muscle stretch(GO:0035994)
0.1 0.7 GO:0006572 tyrosine catabolic process(GO:0006572)
0.1 0.6 GO:1904030 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.1 0.5 GO:0051013 microtubule severing(GO:0051013)
0.0 0.2 GO:0048855 adenohypophysis morphogenesis(GO:0048855)
0.0 0.3 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.2 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.0 0.2 GO:1901673 regulation of mitotic spindle assembly(GO:1901673)
0.0 0.2 GO:0000305 response to superoxide(GO:0000303) response to oxygen radical(GO:0000305) removal of superoxide radicals(GO:0019430) cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451) cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
0.0 0.1 GO:0019364 pyridine nucleotide catabolic process(GO:0019364) NAD catabolic process(GO:0019677) pyridine-containing compound catabolic process(GO:0072526)
0.0 0.4 GO:0045661 regulation of myoblast differentiation(GO:0045661)
0.0 1.9 GO:0006637 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.0 0.1 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 0.1 GO:1901031 response to leucine(GO:0043201) cellular response to leucine(GO:0071233) regulation of response to reactive oxygen species(GO:1901031)
0.0 0.3 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 0.2 GO:0030719 P granule organization(GO:0030719)
0.0 0.2 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.0 0.2 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 0.3 GO:0070593 dendrite self-avoidance(GO:0070593)
0.0 0.2 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.0 0.1 GO:0007190 activation of adenylate cyclase activity(GO:0007190) positive regulation of cAMP metabolic process(GO:0030816) positive regulation of cAMP biosynthetic process(GO:0030819) positive regulation of adenylate cyclase activity(GO:0045762)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0016600 flotillin complex(GO:0016600)
0.1 0.2 GO:0033391 chromatoid body(GO:0033391)
0.0 0.2 GO:0000814 ESCRT II complex(GO:0000814)
0.0 0.2 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 0.1 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.3 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.1 GO:0061700 GATOR2 complex(GO:0061700)
0.0 0.2 GO:0032039 integrator complex(GO:0032039)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0004087 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087)
0.1 0.7 GO:0016823 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.1 0.4 GO:0070004 cysteine-type exopeptidase activity(GO:0070004)
0.1 0.6 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 0.2 GO:0001729 ceramide kinase activity(GO:0001729)
0.1 0.6 GO:0051920 peroxiredoxin activity(GO:0051920)
0.0 0.5 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 1.9 GO:0016790 thiolester hydrolase activity(GO:0016790)
0.0 0.9 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.3 GO:0017002 activin-activated receptor activity(GO:0017002)
0.0 0.4 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.2 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.1 GO:0070728 leucine binding(GO:0070728)
0.0 0.1 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.0 0.6 GO:0043022 ribosome binding(GO:0043022)
0.0 0.0 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.0 0.2 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.3 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.0 0.2 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters