Project

PRJEB1986: zebrafish developmental stages transcriptome

Navigation
Downloads

Results for pitx2

Z-value: 1.07

Motif logo

logo of

Transcription factors associated with pitx2

Gene Symbol Gene ID Gene Info
pitx2
ENSDARG00000036194 paired-like homeodomain 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
pitx2dr11_v1_chr14_+_36218072_362180720.598.2e-03Click!

Activity profile of pitx2 motif

Sorted Z-values of pitx2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_35949936 3.90 ENSDART00000192583
AL954682.1

chr2_-_31767827 3.40 ENSDART00000114928
and2
actinodin2
chr20_+_9128829 3.36 ENSDART00000064144
ENSDART00000137450
bpnt1
bisphosphate nucleotidase 1
chr4_+_6643421 3.27 ENSDART00000099462
gpr85
G protein-coupled receptor 85
chr6_-_54126463 2.82 ENSDART00000161059
tusc2a
tumor suppressor candidate 2a
chr19_-_3193912 2.24 ENSDART00000133159
si:ch211-133n4.6
si:ch211-133n4.6
chr19_-_5345930 2.20 ENSDART00000066620
ENSDART00000151398
krtt1c19e
keratin type 1 c19e
chr15_-_12319065 1.99 ENSDART00000162973
ENSDART00000170543
fxyd6
FXYD domain containing ion transport regulator 6
chr19_+_10339538 1.88 ENSDART00000151808
ENSDART00000151235
rcvrn3
recoverin 3
chr23_+_3616224 1.87 ENSDART00000190917
si:dkey-9l20.3
si:dkey-9l20.3
chr23_+_3602779 1.86 ENSDART00000013629
si:dkey-9l20.3
si:dkey-9l20.3
chr23_+_3618454 1.81 ENSDART00000189393
si:dkey-9l20.3
si:dkey-9l20.3
chr8_-_18239494 1.75 ENSDART00000079989
ENSDART00000022959
guk1b
guanylate kinase 1b
chr23_+_3620618 1.71 ENSDART00000190126
si:dkey-9l20.3
si:dkey-9l20.3
chr23_+_3607305 1.71 ENSDART00000186190
si:dkey-9l20.3
si:dkey-9l20.3
chr10_+_21511495 1.67 ENSDART00000178395
BX957322.3

chr23_+_3627379 1.64 ENSDART00000187279
si:dkey-9l20.3
si:dkey-9l20.3
chr23_+_3596401 1.63 ENSDART00000185908
si:dkey-9l20.3
si:dkey-9l20.3
chr23_+_3611765 1.61 ENSDART00000181481
si:dkey-9l20.3
si:dkey-9l20.3
chr23_+_3591690 1.61 ENSDART00000180822
si:dkey-9l20.3
si:dkey-9l20.3
chr23_+_3613994 1.60 ENSDART00000183763
si:dkey-9l20.3
si:dkey-9l20.3
chr23_+_3609535 1.58 ENSDART00000191440
si:dkey-9l20.3
si:dkey-9l20.3
chr23_+_3622920 1.57 ENSDART00000183091
si:dkey-9l20.3
si:dkey-9l20.3
chr23_+_3625083 1.56 ENSDART00000184958
si:dkey-9l20.3
si:dkey-9l20.3
chr25_+_6306885 1.53 ENSDART00000142705
ENSDART00000067510
crabp1a
cellular retinoic acid binding protein 1a
chr5_+_26075230 1.48 ENSDART00000098473
klf9
Kruppel-like factor 9
chr2_+_49522178 1.46 ENSDART00000056254
stap2a
signal transducing adaptor family member 2a
chr23_+_3594171 1.46 ENSDART00000159609
si:dkey-9l20.3
si:dkey-9l20.3
chr19_-_9829965 1.44 ENSDART00000136842
ENSDART00000142766
cacng8a
calcium channel, voltage-dependent, gamma subunit 8a
chr16_-_28836523 1.43 ENSDART00000108596
ENSDART00000142920
plin6
perilipin 6
chr23_+_3598320 1.43 ENSDART00000189608
si:dkey-9l20.3
si:dkey-9l20.3
chr23_+_3587230 1.42 ENSDART00000055103
si:dkey-9l20.3
si:dkey-9l20.3
chr23_+_3605325 1.42 ENSDART00000182713
si:dkey-9l20.3
si:dkey-9l20.3
chr23_+_3589711 1.39 ENSDART00000187435
si:dkey-9l20.3
si:dkey-9l20.3
chr23_+_3600866 1.39 ENSDART00000184376
si:dkey-9l20.3
si:dkey-9l20.3
chr23_+_3585251 1.37 ENSDART00000187356
si:dkey-9l20.3
si:dkey-9l20.3
chr6_+_21740672 1.34 ENSDART00000193734
lhfpl4a
lipoma HMGIC fusion partner-like 4a
chr25_-_28384954 1.32 ENSDART00000073500
ptprz1a
protein tyrosine phosphatase, receptor-type, Z polypeptide 1a
chr16_-_43971258 1.32 ENSDART00000141941
zfpm2a
zinc finger protein, FOG family member 2a
chr21_+_22630627 1.32 ENSDART00000193092
si:dkeyp-69c1.7
si:dkeyp-69c1.7
chr10_+_29963518 1.29 ENSDART00000011317
ENSDART00000099964
ENSDART00000182990
ENSDART00000113912
ntm
neurotrimin
chr1_+_7546259 1.25 ENSDART00000015732
mylz3
myosin, light polypeptide 3, skeletal muscle
chr1_+_31942961 1.23 ENSDART00000007522
anos1a
anosmin 1a
chr12_-_4841018 1.20 ENSDART00000166500
zgc:163073
zgc:163073
chr9_-_9980704 1.15 ENSDART00000130243
ENSDART00000193475
ugt1ab
UDP glucuronosyltransferase 1 family a, b
chr6_-_39344259 1.14 ENSDART00000104074
zgc:158846
zgc:158846
chr17_-_50331351 1.14 ENSDART00000149294
otofb
otoferlin b
chr6_-_58149165 1.13 ENSDART00000170752
tox2
TOX high mobility group box family member 2
chr24_-_27400630 1.12 ENSDART00000165760
ccl34b.1
chemokine (C-C motif) ligand 34b, duplicate 1
chr14_-_2270973 1.12 ENSDART00000180729
pcdh2ab9
protocadherin 2 alpha b 9
chr8_+_19356072 1.10 ENSDART00000063272
mpeg1.2
macrophage expressed 1, tandem duplicate 2
chr23_-_24856025 1.09 ENSDART00000142171
syt6a
synaptotagmin VIa
chr20_+_9128256 1.07 ENSDART00000163883
ENSDART00000183072
ENSDART00000187276
bpnt1
bisphosphate nucleotidase 1
chr21_+_41743493 1.07 ENSDART00000192669
ppp2r2bb
protein phosphatase 2, regulatory subunit B, beta b
chr8_+_41533268 1.06 ENSDART00000142377
si:ch211-158d24.2
si:ch211-158d24.2
chr22_-_18491813 1.06 ENSDART00000105419
si:ch211-212d10.2
si:ch211-212d10.2
chr24_+_34085940 1.06 ENSDART00000171189
asb10
ankyrin repeat and SOCS box containing 10
chr25_-_7999756 1.01 ENSDART00000159908
camk1db
calcium/calmodulin-dependent protein kinase 1Db
chr21_+_22630297 1.01 ENSDART00000147175
si:dkeyp-69c1.7
si:dkeyp-69c1.7
chr5_-_72125551 1.00 ENSDART00000149412
smyd1a
SET and MYND domain containing 1a
chr5_-_67145505 0.99 ENSDART00000011295
rom1a
retinal outer segment membrane protein 1a
chr3_-_28828569 0.97 ENSDART00000167679
si:ch211-76l23.4
si:ch211-76l23.4
chr20_+_36233873 0.93 ENSDART00000131867
cnih3
cornichon family AMPA receptor auxiliary protein 3
chr25_+_25124684 0.92 ENSDART00000167542
ldha
lactate dehydrogenase A4
chr23_-_40250886 0.91 ENSDART00000041912
tgm1l3
transglutaminase 1 like 3
chr25_+_10458990 0.91 ENSDART00000130354
ENSDART00000044738
ric8a
RIC8 guanine nucleotide exchange factor A
chr13_-_30028103 0.91 ENSDART00000183889
scdb
stearoyl-CoA desaturase b
chr22_+_17509422 0.90 ENSDART00000088419
march2
membrane-associated ring finger (C3HC4) 2
chr20_+_18225329 0.90 ENSDART00000144172
kctd1
potassium channel tetramerization domain containing 1
chr9_-_9998087 0.89 ENSDART00000124423
ugt1ab
UDP glucuronosyltransferase 1 family a, b
chr24_+_24461341 0.87 ENSDART00000147658
bhlhe22
basic helix-loop-helix family, member e22
chr7_-_29021757 0.87 ENSDART00000086905
nrn1lb
neuritin 1-like b
chr6_+_2093206 0.84 ENSDART00000114314
tgm2b
transglutaminase 2b
chr5_-_65158203 0.81 ENSDART00000171656
sh2d3cb
SH2 domain containing 3Cb
chr23_-_45682136 0.81 ENSDART00000164646
fam160a1b
family with sequence similarity 160, member A1b
chr1_+_55755304 0.80 ENSDART00000144983
tecrb
trans-2,3-enoyl-CoA reductase b
chr23_+_28731379 0.80 ENSDART00000047378
cort
cortistatin
chr5_+_24287927 0.79 ENSDART00000143563
zdhhc23a
zinc finger, DHHC-type containing 23a
chr7_-_66864756 0.79 ENSDART00000184462
ENSDART00000189424
ampd3a
adenosine monophosphate deaminase 3a
chr1_+_11881559 0.79 ENSDART00000166981
snx8b
sorting nexin 8b
chr7_-_48173440 0.79 ENSDART00000124075
mtss1lb
metastasis suppressor 1-like b
chr9_+_34127005 0.76 ENSDART00000167384
ENSDART00000078065
f5
coagulation factor V
chr1_+_44826593 0.76 ENSDART00000162200
STX3
zgc:165520
chr8_+_694218 0.76 ENSDART00000147753
rnf165b
ring finger protein 165b
chr1_-_26293203 0.75 ENSDART00000180140
cxxc4
CXXC finger 4
chr24_+_36636208 0.75 ENSDART00000139211
si:ch73-334d15.4
si:ch73-334d15.4
chr13_-_16222388 0.73 ENSDART00000182861
zgc:110045
zgc:110045
chr1_-_26292897 0.73 ENSDART00000112899
ENSDART00000185410
cxxc4
CXXC finger 4
chr23_+_9867483 0.72 ENSDART00000023099
slc16a7
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
chr5_-_29488245 0.72 ENSDART00000047719
ENSDART00000141154
ENSDART00000171165
cacna1ba
calcium channel, voltage-dependent, N type, alpha 1B subunit, a
chr17_+_5915875 0.72 ENSDART00000184179
fndc4b
fibronectin type III domain containing 4b
chr8_+_554531 0.71 ENSDART00000193623
FO704758.2

chr18_-_17001056 0.71 ENSDART00000112627
tph2
tryptophan hydroxylase 2 (tryptophan 5-monooxygenase)
chr25_-_19090479 0.70 ENSDART00000027465
ENSDART00000177670
cacna2d4b
calcium channel, voltage-dependent, alpha 2/delta subunit 4b
chr18_-_21806613 0.70 ENSDART00000145721
nrn1la
neuritin 1-like a
chr21_+_6290566 0.70 ENSDART00000161647
fnbp1b
formin binding protein 1b
chr11_-_26832685 0.70 ENSDART00000153519
iqsec1b
IQ motif and Sec7 domain 1b
chr3_+_16762483 0.69 ENSDART00000132732
tmem86b
transmembrane protein 86B
chr13_+_16522608 0.68 ENSDART00000182838
ENSDART00000143200
kcnma1a
potassium large conductance calcium-activated channel, subfamily M, alpha member 1a
chr23_-_35547613 0.67 ENSDART00000122387
alkal2a
ALK and LTK ligand 2a
chr5_-_23277939 0.66 ENSDART00000003514
plp1b
proteolipid protein 1b
chr23_+_43849190 0.66 ENSDART00000017375
cnga1
cyclic nucleotide gated channel alpha 1
chr20_-_14875308 0.65 ENSDART00000141290
dnm3a
dynamin 3a
chr17_-_5583345 0.64 ENSDART00000035944
clic5a
chloride intracellular channel 5a
chr23_-_27505825 0.63 ENSDART00000137229
ENSDART00000013797
asb8
ankyrin repeat and SOCS box containing 8
chr6_+_37894914 0.62 ENSDART00000148817
oca2
oculocutaneous albinism II
chr7_+_19738665 0.62 ENSDART00000089333
tkfc
triokinase/FMN cyclase
chr14_+_44545092 0.61 ENSDART00000175454
lingo2a
leucine rich repeat and Ig domain containing 2a
chr20_+_41640687 0.60 ENSDART00000138686
fam184a
family with sequence similarity 184, member A
chr13_-_29505604 0.60 ENSDART00000110005
cdhr1a
cadherin-related family member 1a
chr18_-_17000842 0.60 ENSDART00000079832
tph2
tryptophan hydroxylase 2 (tryptophan 5-monooxygenase)
chr6_-_30859656 0.58 ENSDART00000156235
pde4ba
phosphodiesterase 4B, cAMP-specific a
chr5_-_38094130 0.58 ENSDART00000131831
si:ch211-284e13.4
si:ch211-284e13.4
chr10_+_29137482 0.58 ENSDART00000178280
picalma
phosphatidylinositol binding clathrin assembly protein a
chr7_+_42208859 0.57 ENSDART00000148643
phkb
phosphorylase kinase, beta
chr19_-_25271155 0.55 ENSDART00000104027
rims3
regulating synaptic membrane exocytosis 3
chr7_-_8408014 0.55 ENSDART00000112492
zgc:194686
zgc:194686
chr10_-_43392267 0.55 ENSDART00000142872
edil3b
EGF-like repeats and discoidin I-like domains 3b
chr20_-_20533865 0.54 ENSDART00000125039
six6b
SIX homeobox 6b
chr21_+_13366353 0.54 ENSDART00000151630
si:ch73-62l21.1
si:ch73-62l21.1
chr14_-_2206476 0.54 ENSDART00000081870
pcdh2ab6
protocadherin 2 alpha b 6
chr14_+_41518257 0.54 ENSDART00000050037
chrnb3b
cholinergic receptor, nicotinic, beta 3b (neuronal)
chr6_+_39506043 0.54 ENSDART00000086260
CR388364.1

chr20_-_30369598 0.53 ENSDART00000144549
allc
allantoicase
chr3_+_15296824 0.53 ENSDART00000043801
cabp5b
calcium binding protein 5b
chr23_-_15330168 0.53 ENSDART00000035865
ENSDART00000143635
sulf2b
sulfatase 2b
chr11_-_44409856 0.53 ENSDART00000162886
il1rapl1b
interleukin 1 receptor accessory protein-like 1b
chr8_-_54304381 0.52 ENSDART00000184177
RHO (1 of many)
rhodopsin
chr20_-_18731268 0.52 ENSDART00000183893
enpp5
ectonucleotide pyrophosphatase/phosphodiesterase 5
chr13_+_24280380 0.52 ENSDART00000184115
acta1b
actin, alpha 1b, skeletal muscle
chr10_+_26926654 0.51 ENSDART00000078980
ENSDART00000100289
rab1bb
RAB1B, member RAS oncogene family b
chr5_+_63749368 0.51 ENSDART00000135097
si:ch73-274k23.1
si:ch73-274k23.1
chr10_+_15777064 0.50 ENSDART00000114483
apba1b
amyloid beta (A4) precursor protein-binding, family A, member 1b
chr13_-_30027730 0.50 ENSDART00000044009
scdb
stearoyl-CoA desaturase b
chr7_-_16204885 0.50 ENSDART00000171008
btr05
bloodthirsty-related gene family, member 5
chr3_+_42923275 0.49 ENSDART00000168228
tmem184a
transmembrane protein 184a
chr11_-_28148033 0.49 ENSDART00000177182
lactbl1b
lactamase, beta-like 1b
chr23_+_8989168 0.49 ENSDART00000034380
xkr7
XK, Kell blood group complex subunit-related family, member 7
chr4_-_20232974 0.49 ENSDART00000193353
stk38l
serine/threonine kinase 38 like
chr8_+_50983551 0.49 ENSDART00000142061
si:dkey-32e23.4
si:dkey-32e23.4
chr20_-_54564018 0.48 ENSDART00000099832
zgc:153012
zgc:153012
chr3_-_21061931 0.48 ENSDART00000036741
fam57ba
family with sequence similarity 57, member Ba
chr7_-_57933736 0.48 ENSDART00000142580
ank2b
ankyrin 2b, neuronal
chr23_+_21638258 0.46 ENSDART00000104188
igsf21b
immunoglobin superfamily, member 21b
chr13_+_15816573 0.46 ENSDART00000137061
klc1a
kinesin light chain 1a
chr2_-_2020044 0.46 ENSDART00000024135
tubb2
tubulin, beta 2A class IIa
chr18_-_27628784 0.46 ENSDART00000180885
BX005470.1

chr22_-_23625351 0.46 ENSDART00000192588
ENSDART00000163423
cfhl4
complement factor H like 4
chr6_+_45347219 0.46 ENSDART00000188240
LO017951.1

chr11_-_27057572 0.46 ENSDART00000043091
iqsec1b
IQ motif and Sec7 domain 1b
chr25_-_13839743 0.46 ENSDART00000158780
mapk8ip1a
mitogen-activated protein kinase 8 interacting protein 1a
chr7_-_22132265 0.45 ENSDART00000125284
ENSDART00000112978
nlgn2a
neuroligin 2a
chr18_+_36806545 0.45 ENSDART00000098958
ttc9b
tetratricopeptide repeat domain 9B
chr1_+_26012668 0.44 ENSDART00000182428
BX323448.1

chr2_+_31475772 0.44 ENSDART00000130722
cacnb2b
calcium channel, voltage-dependent, beta 2b
chr23_-_27506161 0.43 ENSDART00000145007
asb8
ankyrin repeat and SOCS box containing 8
chr14_-_2264494 0.43 ENSDART00000191149
pcdh2ab9
protocadherin 2 alpha b 9
chr19_+_12762887 0.42 ENSDART00000139909
mc5ra
melanocortin 5a receptor
chr3_-_58585854 0.42 ENSDART00000123546
CABZ01038521.1

chr4_+_8168514 0.41 ENSDART00000150830
ninj2
ninjurin 2
chr2_-_11258547 0.41 ENSDART00000165803
ENSDART00000193817
slc44a5a
solute carrier family 44, member 5a
chr11_+_25101220 0.41 ENSDART00000183700
ndrg3a
ndrg family member 3a
chr12_+_17106117 0.41 ENSDART00000149990
acta2
actin, alpha 2, smooth muscle, aorta
chr19_+_37701450 0.41 ENSDART00000087694
thsd7aa
thrombospondin, type I, domain containing 7Aa
chr13_-_49666615 0.41 ENSDART00000148083
tomm20a
translocase of outer mitochondrial membrane 20
chr8_+_4337312 0.41 ENSDART00000182228
myl2b
myosin, light chain 2b, regulatory, cardiac, slow
chr11_-_16093018 0.40 ENSDART00000139309
ENSDART00000139819
SPATA1
si:dkey-205k8.5
chr19_-_28283844 0.40 ENSDART00000151756
ENSDART00000079104
ndufs6
NADH dehydrogenase (ubiquinone) Fe-S protein 6
chr8_+_27807974 0.39 ENSDART00000078509
capza1b
capping protein (actin filament) muscle Z-line, alpha 1b
chr11_+_8152872 0.39 ENSDART00000091638
ENSDART00000138057
ENSDART00000166379
samd13
sterile alpha motif domain containing 13
chr22_-_18164835 0.38 ENSDART00000143189
rfxank
regulatory factor X-associated ankyrin-containing protein
chr14_+_46020282 0.38 ENSDART00000190087
c1qtnf2
C1q and TNF related 2
chr11_+_5926850 0.38 ENSDART00000104364
rps15
ribosomal protein S15
chr3_+_52806347 0.38 ENSDART00000168151
ENSDART00000098826
lmx1al
LIM homeobox transcription factor 1, alpha-like
chr23_-_24825863 0.37 ENSDART00000112493
syt6a
synaptotagmin VIa
chr5_+_24282570 0.37 ENSDART00000041905
zdhhc23a
zinc finger, DHHC-type containing 23a
chr16_-_13004166 0.36 ENSDART00000133735
cacng7b
calcium channel, voltage-dependent, gamma subunit 7b
chr12_+_316238 0.35 ENSDART00000187492
rcvrnb
recoverin b
chr20_-_25436389 0.35 ENSDART00000153266
itsn2a
intersectin 2a
chr16_-_17188294 0.35 ENSDART00000165883
opn9
opsin 9
chr9_+_307863 0.35 ENSDART00000163474
stac3
SH3 and cysteine rich domain 3
chr7_+_38588866 0.35 ENSDART00000015682
ndufs3
NADH dehydrogenase (ubiquinone) Fe-S protein 3, (NADH-coenzyme Q reductase)
chr1_-_1894722 0.34 ENSDART00000165669
si:ch211-132g1.3
si:ch211-132g1.3
chr12_+_28995942 0.34 ENSDART00000076334
valopb
vertebrate ancient long opsin b
chr17_+_43889371 0.34 ENSDART00000156871
ENSDART00000154702
msh4
mutS homolog 4
chr25_+_3788074 0.33 ENSDART00000154008
chid1
chitinase domain containing 1
chr10_+_36150911 0.33 ENSDART00000076804
waif2
Wnt-activated inhibitory factor 2
chr11_-_270210 0.32 ENSDART00000005217
ENSDART00000172779
alas1
aminolevulinate, delta-, synthase 1
chr17_+_25289431 0.32 ENSDART00000161002
kbtbd11
kelch repeat and BTB (POZ) domain containing 11
chr5_+_61467618 0.32 ENSDART00000074073
ENSDART00000182094
alkbh4
alkB homolog 4, lysine demthylase
chr18_-_39702327 0.32 ENSDART00000149158
dmxl2
Dmx-like 2
chr13_+_50151407 0.31 ENSDART00000031858
gpr137ba
G protein-coupled receptor 137Ba
chr25_-_13703826 0.31 ENSDART00000163398
pla2g15
phospholipase A2, group XV
chr15_-_24883956 0.31 ENSDART00000113199
aipl1
aryl hydrocarbon receptor interacting protein-like 1
chr14_+_9009600 0.31 ENSDART00000133904
si:ch211-274f20.2
si:ch211-274f20.2
chr14_+_40874608 0.31 ENSDART00000168448
si:ch211-106m9.1
si:ch211-106m9.1
chr9_+_54695981 0.31 ENSDART00000183605
rab9a
RAB9A, member RAS oncogene family
chr17_-_47142249 0.30 ENSDART00000184705
CU915775.1

chr6_-_46162585 0.30 ENSDART00000017309
ca16b
carbonic anhydrase XVI b
chr6_-_36182115 0.30 ENSDART00000154639
brinp3a.2
bone morphogenetic protein/retinoic acid inducible neural-specific 3a, tandem duplicate 2

Network of associatons between targets according to the STRING database.

First level regulatory network of pitx2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.8 GO:0051881 regulation of mitochondrial membrane potential(GO:0051881)
0.4 1.5 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.3 1.3 GO:0097112 gamma-aminobutyric acid receptor clustering(GO:0097112)
0.3 1.5 GO:0034653 diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
0.3 1.4 GO:0043476 pigment accumulation(GO:0043476)
0.2 31.6 GO:0007160 cell-matrix adhesion(GO:0007160)
0.2 1.3 GO:1901162 serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.2 4.6 GO:0071545 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855) inositol phosphate catabolic process(GO:0071545)
0.2 0.5 GO:0000256 allantoin catabolic process(GO:0000256)
0.2 1.9 GO:0036368 cone photoresponse recovery(GO:0036368)
0.1 1.8 GO:0010996 response to auditory stimulus(GO:0010996)
0.1 0.4 GO:0090131 mesenchyme migration(GO:0090131)
0.1 0.7 GO:0070378 ERK5 cascade(GO:0070375) regulation of ERK5 cascade(GO:0070376) positive regulation of ERK5 cascade(GO:0070378)
0.1 1.1 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.1 1.1 GO:0071941 nitrogen cycle metabolic process(GO:0071941)
0.1 1.8 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.1 0.3 GO:1901546 regulation of cellular pH reduction(GO:0032847) synaptic vesicle lumen acidification(GO:0097401) regulation of synaptic vesicle lumen acidification(GO:1901546)
0.1 0.5 GO:0016322 neuron remodeling(GO:0016322)
0.1 0.3 GO:0045671 negative regulation of osteoclast differentiation(GO:0045671)
0.1 0.6 GO:0019563 glycerol catabolic process(GO:0019563)
0.1 0.5 GO:1903146 regulation of mitophagy(GO:1903146)
0.1 0.5 GO:0036371 protein localization to T-tubule(GO:0036371)
0.1 1.2 GO:0021988 olfactory bulb development(GO:0021772) olfactory lobe development(GO:0021988)
0.1 1.0 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.1 0.6 GO:0021627 olfactory nerve development(GO:0021553) olfactory nerve morphogenesis(GO:0021627) olfactory nerve formation(GO:0021628)
0.1 0.3 GO:0061010 gall bladder development(GO:0061010)
0.1 1.6 GO:0018149 peptide cross-linking(GO:0018149)
0.1 0.3 GO:1901387 positive regulation of voltage-gated calcium channel activity(GO:1901387)
0.1 0.6 GO:0042438 melanin biosynthetic process(GO:0042438)
0.1 0.2 GO:0042754 negative regulation of circadian rhythm(GO:0042754)
0.1 0.2 GO:0015860 intracellular nucleoside transport(GO:0015859) purine nucleoside transmembrane transport(GO:0015860) purine nucleotide transport(GO:0015865) ATP transport(GO:0015867) purine ribonucleotide transport(GO:0015868) adenine nucleotide transport(GO:0051503) mitochondrial ATP transmembrane transport(GO:1990544)
0.1 0.8 GO:0032264 IMP salvage(GO:0032264)
0.0 0.7 GO:0046549 retinal cone cell development(GO:0046549)
0.0 0.3 GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447)
0.0 0.3 GO:0051898 negative regulation of protein kinase B signaling(GO:0051898)
0.0 0.2 GO:0007618 mating(GO:0007618)
0.0 0.5 GO:0070782 phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.0 1.2 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185) synaptic vesicle budding(GO:0070142)
0.0 0.4 GO:0097105 presynaptic membrane organization(GO:0097090) postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105)
0.0 0.6 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.8 GO:0097178 ruffle assembly(GO:0097178)
0.0 1.1 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.5 GO:0035860 esophagus smooth muscle contraction(GO:0014846) glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.0 0.8 GO:0033135 regulation of peptidyl-serine phosphorylation(GO:0033135) positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.0 0.4 GO:0035094 response to nicotine(GO:0035094)
0.0 1.7 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.0 0.1 GO:0060907 macrophage cytokine production(GO:0010934) regulation of macrophage cytokine production(GO:0010935) positive regulation of macrophage cytokine production(GO:0060907)
0.0 0.7 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.0 0.7 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0 1.5 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.0 0.3 GO:0000710 meiotic mismatch repair(GO:0000710)
0.0 0.6 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.3 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.6 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.2 GO:0071908 determination of intestine left/right asymmetry(GO:0071908)
0.0 0.5 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.2 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.2 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 0.2 GO:1990108 protein linear deubiquitination(GO:1990108)
0.0 1.1 GO:0002548 monocyte chemotaxis(GO:0002548)
0.0 0.8 GO:0042761 very long-chain fatty acid biosynthetic process(GO:0042761)
0.0 1.1 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.5 GO:0018023 peptidyl-lysine trimethylation(GO:0018023)
0.0 0.2 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.0 3.4 GO:0033333 fin development(GO:0033333)
0.0 0.2 GO:0031034 myosin filament assembly(GO:0031034) striated muscle myosin thick filament assembly(GO:0071688)
0.0 1.3 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 0.3 GO:0098508 endothelial to hematopoietic transition(GO:0098508)
0.0 0.4 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 0.8 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.3 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.0 0.3 GO:0070989 oxidative demethylation(GO:0070989)
0.0 0.2 GO:0046085 adenosine metabolic process(GO:0046085)
0.0 0.1 GO:1904019 epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035)
0.0 0.1 GO:0044211 CTP salvage(GO:0044211)
0.0 0.5 GO:0008286 insulin receptor signaling pathway(GO:0008286)
0.0 1.9 GO:0051260 protein homooligomerization(GO:0051260)
0.0 0.1 GO:0006783 heme biosynthetic process(GO:0006783)
0.0 0.4 GO:0072015 glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.0 0.5 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.5 GO:0032482 Rab protein signal transduction(GO:0032482)
0.0 0.2 GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902041) negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042)
0.0 0.1 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.0 0.1 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.0 0.2 GO:0016199 axon midline choice point recognition(GO:0016199)
0.0 0.7 GO:0007602 phototransduction(GO:0007602)
0.0 0.6 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.0 GO:0048169 regulation of long-term neuronal synaptic plasticity(GO:0048169)
0.0 0.1 GO:2001286 caveolin-mediated endocytosis(GO:0072584) negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286) negative regulation of caveolin-mediated endocytosis(GO:2001287)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0060077 inhibitory synapse(GO:0060077)
0.1 1.1 GO:0045095 keratin filament(GO:0045095)
0.1 0.3 GO:0043291 RAVE complex(GO:0043291)
0.1 0.4 GO:0008290 F-actin capping protein complex(GO:0008290)
0.1 0.6 GO:0098835 presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) extrinsic component of presynaptic membrane(GO:0098888) extrinsic component of presynaptic endocytic zone(GO:0098894)
0.1 0.8 GO:0030315 T-tubule(GO:0030315)
0.0 0.3 GO:0033557 Slx1-Slx4 complex(GO:0033557)
0.0 1.1 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 0.6 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 0.7 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 1.8 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.3 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 0.4 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.3 GO:0070938 contractile ring(GO:0070938)
0.0 0.7 GO:0031430 M band(GO:0031430)
0.0 0.7 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.0 1.4 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.5 GO:0005869 dynactin complex(GO:0005869)
0.0 1.1 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 1.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.3 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.2 GO:0038039 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor heterodimeric complex(GO:0038039) G-protein coupled receptor complex(GO:0097648)
0.0 0.1 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 2.2 GO:0005882 intermediate filament(GO:0005882)
0.0 0.4 GO:0043209 myelin sheath(GO:0043209)
0.0 0.8 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.1 GO:0016589 NURF complex(GO:0016589)
0.0 0.2 GO:0071797 LUBAC complex(GO:0071797)
0.0 0.5 GO:0043679 axon terminus(GO:0043679)
0.0 0.2 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.3 GO:0000795 synaptonemal complex(GO:0000795)
0.0 1.3 GO:0005604 basement membrane(GO:0005604)
0.0 0.9 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.6 GO:0005811 lipid particle(GO:0005811)
0.0 1.5 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.5 GO:0016215 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215) palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.4 1.8 GO:0004385 guanylate kinase activity(GO:0004385)
0.3 1.3 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.2 4.7 GO:0008252 nucleotidase activity(GO:0008252)
0.2 0.5 GO:0050135 NAD(P)+ nucleosidase activity(GO:0050135)
0.2 1.1 GO:0098809 nitrite reductase activity(GO:0098809)
0.1 0.9 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 0.7 GO:0030298 receptor signaling protein tyrosine kinase activator activity(GO:0030298)
0.1 0.3 GO:0016748 succinyltransferase activity(GO:0016748)
0.1 1.5 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 1.1 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.1 0.7 GO:0016803 ether hydrolase activity(GO:0016803)
0.1 1.6 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 1.0 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 0.8 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1 1.4 GO:0050811 GABA receptor binding(GO:0050811)
0.1 1.7 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 0.5 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.1 1.5 GO:0035591 signaling adaptor activity(GO:0035591)
0.1 0.2 GO:0005471 ATP:ADP antiporter activity(GO:0005471)
0.1 0.4 GO:0004977 melanocortin receptor activity(GO:0004977)
0.1 0.2 GO:0097643 amylin receptor activity(GO:0097643)
0.1 3.0 GO:0005178 integrin binding(GO:0005178)
0.0 0.6 GO:0005158 insulin receptor binding(GO:0005158)
0.0 0.6 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.1 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.0 3.7 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 1.0 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.7 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.2 GO:0004945 angiotensin type I receptor activity(GO:0001596) angiotensin type II receptor activity(GO:0004945)
0.0 2.0 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.8 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.5 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.2 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.4 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 1.1 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 0.6 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.6 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.5 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.3 GO:0008061 chitin binding(GO:0008061)
0.0 0.2 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.3 GO:0005222 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.0 0.4 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.9 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.3 GO:0030983 mismatched DNA binding(GO:0030983)
0.0 0.2 GO:0004096 catalase activity(GO:0004096)
0.0 0.1 GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
0.0 0.1 GO:0004849 uridine kinase activity(GO:0004849)
0.0 1.1 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.8 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.7 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.3 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.3 GO:0002039 p53 binding(GO:0002039)
0.0 0.7 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.3 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.6 GO:0044325 ion channel binding(GO:0044325)
0.0 0.8 GO:0005507 copper ion binding(GO:0005507)
0.0 0.7 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.8 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors(GO:0016627)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.4 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.3 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.7 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 0.7 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.7 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.7 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.4 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 1.3 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 0.2 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.1 0.8 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.4 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.7 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.0 0.7 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.6 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.1 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.3 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.4 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.4 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.8 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.2 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.2 REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS Genes involved in Post NMDA receptor activation events
0.0 0.1 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins