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PRJEB1986: zebrafish developmental stages transcriptome

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Results for rest

Z-value: 5.40

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Transcription factors associated with rest

Gene Symbol Gene ID Gene Info
rest
ENSDARG00000103046 Danio rerio RE1-silencing transcription factor (rest), mRNA.

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
restdr11_v1_chr14_-_52433292_52433292-0.681.5e-03Click!

Activity profile of rest motif

Sorted Z-values of rest motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_17676745 44.40 ENSDART00000030665
slc25a4
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
chr5_-_29643930 31.00 ENSDART00000161250
grin1b
glutamate receptor, ionotropic, N-methyl D-aspartate 1b
chr5_-_29643381 28.62 ENSDART00000034849
grin1b
glutamate receptor, ionotropic, N-methyl D-aspartate 1b
chr17_-_12385308 24.39 ENSDART00000080927
snap25b
synaptosomal-associated protein, 25b
chr21_+_11468642 23.83 ENSDART00000041869
grin1a
glutamate receptor, ionotropic, N-methyl D-aspartate 1a
chr15_+_36156986 23.70 ENSDART00000059791
sst1.1
somatostatin 1, tandem duplicate 1
chr21_-_42100471 23.06 ENSDART00000166148
gabra1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr25_-_22639133 21.22 ENSDART00000073583
islr2
immunoglobulin superfamily containing leucine-rich repeat 2
chr16_+_46148990 20.59 ENSDART00000083919
sv2a
synaptic vesicle glycoprotein 2A
chr25_+_35250976 20.08 ENSDART00000003494
slc17a6a
solute carrier family 17 (vesicular glutamate transporter), member 6a
chr23_-_17657348 19.64 ENSDART00000054736
bhlhe23
basic helix-loop-helix family, member e23
chr9_-_34915351 19.53 ENSDART00000100728
ENSDART00000139608
upf3a
UPF3A, regulator of nonsense mediated mRNA decay
chr3_+_33340939 19.09 ENSDART00000128786
pyya
peptide YYa
chr9_-_31915423 18.73 ENSDART00000060051
fgf14
fibroblast growth factor 14
chr6_+_21740672 18.66 ENSDART00000193734
lhfpl4a
lipoma HMGIC fusion partner-like 4a
chr21_+_11468934 17.83 ENSDART00000126045
ENSDART00000129744
ENSDART00000102368
grin1a
glutamate receptor, ionotropic, N-methyl D-aspartate 1a
chr18_+_50089000 17.18 ENSDART00000058936
scamp5b
secretory carrier membrane protein 5b
chr5_-_32092856 16.85 ENSDART00000086181
ENSDART00000181677
cabp7b
calcium binding protein 7b
chr7_+_17229282 16.31 ENSDART00000097982
slc6a5
solute carrier family 6 (neurotransmitter transporter), member 5
chr18_+_660578 16.30 ENSDART00000161203
CELF6
si:dkey-205h23.2
chr23_+_45579497 16.29 ENSDART00000110381
egr4
early growth response 4
chr25_-_19443421 16.05 ENSDART00000067362
cart2
cocaine- and amphetamine-regulated transcript 2
chr14_-_2193248 16.01 ENSDART00000128659
pcdh2ab10
protocadherin 2 alpha b 10
chr5_-_26093945 15.94 ENSDART00000010199
ENSDART00000145096
fam219ab
family with sequence similarity 219, member Ab
chr7_+_23907692 15.94 ENSDART00000045479
syt4
synaptotagmin IV
chr23_+_40452157 15.88 ENSDART00000113106
ENSDART00000140136
soga3b
SOGA family member 3b
chr21_+_6751405 15.39 ENSDART00000037265
ENSDART00000146371
olfm1b
olfactomedin 1b
chr6_+_41255485 15.38 ENSDART00000042683
ENSDART00000186013
cadpsb
Ca2+-dependent activator protein for secretion b
chr18_+_26337869 15.17 ENSDART00000109257
RASGRF1
si:ch211-234p18.3
chr22_-_25033105 15.10 ENSDART00000124220
nptxrb
neuronal pentraxin receptor b
chr1_-_38538284 14.69 ENSDART00000009777
glra3
glycine receptor, alpha 3
chr19_-_19339285 14.36 ENSDART00000158413
ENSDART00000170479
cspg5b
chondroitin sulfate proteoglycan 5b
chr7_-_30087048 14.28 ENSDART00000112743
nmbb
neuromedin Bb
chr6_-_30210378 14.16 ENSDART00000157359
ENSDART00000113924
lrrc7
leucine rich repeat containing 7
chr7_+_26224211 14.13 ENSDART00000173999
vgf
VGF nerve growth factor inducible
chr10_+_21588002 14.01 ENSDART00000100596
pcdh1a6
protocadherin 1 alpha 6
chr4_-_5302866 13.70 ENSDART00000138590
SNAP91 (1 of many)
si:ch211-214j24.9
chr10_-_36927594 13.67 ENSDART00000162046
sez6a
seizure related 6 homolog a
chr7_+_17229980 13.50 ENSDART00000184910
slc6a5
solute carrier family 6 (neurotransmitter transporter), member 5
chr12_+_24342303 13.42 ENSDART00000111239
nrxn1a
neurexin 1a
chr23_-_30785382 13.22 ENSDART00000136156
ENSDART00000131285
myt1a
myelin transcription factor 1a
chr25_-_31863374 13.08 ENSDART00000028338
scamp5a
secretory carrier membrane protein 5a
chr23_+_45910033 12.98 ENSDART00000165025
abcg2a
ATP-binding cassette, sub-family G (WHITE), member 2a
chr7_-_52876683 12.94 ENSDART00000172910
map1aa
microtubule-associated protein 1Aa
chr15_-_22147860 12.92 ENSDART00000149784
scn3b
sodium channel, voltage-gated, type III, beta
chr18_+_28988373 12.86 ENSDART00000018685
syt9a
synaptotagmin IXa
chr4_-_5302162 12.23 ENSDART00000177099
SNAP91 (1 of many)
si:ch211-214j24.9
chr14_-_2267515 12.19 ENSDART00000180988
ENSDART00000130712
pcdh2aa15
protocadherin 2 alpha a 15
chr7_-_32833153 12.04 ENSDART00000099871
ENSDART00000099872
slc17a6b
solute carrier family 17 (vesicular glutamate transporter), member 6b
chr21_+_6751760 11.98 ENSDART00000135914
olfm1b
olfactomedin 1b
chr3_+_33341640 11.97 ENSDART00000186352
pyya
peptide YYa
chr3_-_44753325 11.88 ENSDART00000074543
hs3st4
heparan sulfate (glucosamine) 3-O-sulfotransferase 4
chr20_+_27020201 10.88 ENSDART00000126919
ENSDART00000016014
chga
chromogranin A
chr9_-_27649406 10.80 ENSDART00000181270
ENSDART00000187112
stxbp5l
syntaxin binding protein 5-like
chr10_+_23022263 10.63 ENSDART00000138955
si:dkey-175g6.2
si:dkey-175g6.2
chr20_+_19212962 10.52 ENSDART00000063706
fndc4a
fibronectin type III domain containing 4a
chr17_-_10249095 10.50 ENSDART00000159963
sstr1a
somatostatin receptor 1a
chr3_-_37476475 10.24 ENSDART00000148107
si:ch211-278a6.1
si:ch211-278a6.1
chr15_+_24212847 10.12 ENSDART00000155502
sez6b
seizure related 6 homolog b
chr3_-_13921173 10.09 ENSDART00000159177
ENSDART00000165174
si:dkey-61n16.5
si:dkey-61n16.5
chr20_+_34913069 10.02 ENSDART00000007584
snap25a
synaptosomal-associated protein, 25a
chr23_+_28693278 9.73 ENSDART00000078148
smc1a
structural maintenance of chromosomes 1A
chr23_+_35759843 9.66 ENSDART00000047082
gdap1l1
ganglioside induced differentiation associated protein 1-like 1
chr11_+_77526 9.49 ENSDART00000193521
CABZ01072242.1

chr13_+_25846528 9.25 ENSDART00000087426
bcl11aa
B cell CLL/lymphoma 11Aa
chr7_-_69521481 8.93 ENSDART00000148465
slc1a1
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
chr18_+_36806545 8.85 ENSDART00000098958
ttc9b
tetratricopeptide repeat domain 9B
chr2_-_5776030 8.70 ENSDART00000133851
nyap2b
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2b
chr12_+_24561832 8.50 ENSDART00000088159
nrxn1a
neurexin 1a
chr1_-_201004 8.44 ENSDART00000188956
FO681286.1

chr3_-_59297532 8.32 ENSDART00000187991
CABZ01053748.1

chr6_+_43903209 8.11 ENSDART00000006435
gpr27
G protein-coupled receptor 27
chr19_-_43552252 8.05 ENSDART00000138308
gpr186
G protein-coupled receptor 186
chr11_+_19780717 7.76 ENSDART00000157394
cadpsa
Ca2+-dependent activator protein for secretion a
chr10_+_25219728 7.62 ENSDART00000193829
grm5a
glutamate receptor, metabotropic 5a
chr20_+_45741566 7.33 ENSDART00000113454
chgb
chromogranin B
chr7_+_31879986 7.06 ENSDART00000138491
mybpc3
myosin binding protein C, cardiac
chr11_+_19781053 7.01 ENSDART00000029680
ENSDART00000182743
cadpsa
Ca2+-dependent activator protein for secretion a
chr5_+_71802014 6.43 ENSDART00000124939
ENSDART00000097164
LHX3
LIM homeobox 3
chr13_-_45811137 5.91 ENSDART00000190512
fndc5a
fibronectin type III domain containing 5a
chr6_-_31336317 5.67 ENSDART00000193927
dnajc6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr20_+_41640687 5.64 ENSDART00000138686
fam184a
family with sequence similarity 184, member A
chr23_+_41800052 5.64 ENSDART00000141484
pdyn
prodynorphin
chr19_-_42244358 5.59 ENSDART00000102697
cart4
cocaine- and amphetamine-regulated transcript 4
chr15_-_47841259 5.58 ENSDART00000155384
kbtbd3
kelch repeat and BTB (POZ) domain containing 3
chr14_-_2264494 5.52 ENSDART00000191149
pcdh2ab9
protocadherin 2 alpha b 9
chr17_-_21617618 5.50 ENSDART00000109031
gpr26
G protein-coupled receptor 26
chr15_+_35709223 5.20 ENSDART00000155840
nyap2a
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2a
chr1_+_10720294 5.12 ENSDART00000139387
atp1b1b
ATPase Na+/K+ transporting subunit beta 1b
chr11_+_33426510 5.04 ENSDART00000163106
cntnap5l
contactin associated protein-like 5 like
chr19_-_9648542 4.64 ENSDART00000172628
clcn1a
chloride channel, voltage-sensitive 1a
chr17_+_19630068 4.51 ENSDART00000182619
rgs7a
regulator of G protein signaling 7a
chr17_+_19630272 4.45 ENSDART00000104895
rgs7a
regulator of G protein signaling 7a
chr25_+_5035343 4.03 ENSDART00000011751
parvb
parvin, beta
chr19_+_26718074 4.03 ENSDART00000134455
zgc:100906
zgc:100906
chr16_-_40727455 4.01 ENSDART00000162331
si:dkey-22o22.2
si:dkey-22o22.2
chr12_+_19305390 3.80 ENSDART00000183987
ENSDART00000066391
csnk1e
casein kinase 1, epsilon
chr24_+_854877 3.78 ENSDART00000188408
piezo2a.2
piezo-type mechanosensitive ion channel component 2a, tandem duplicate 2
chr11_+_33426254 3.74 ENSDART00000111193
cntnap5l
contactin associated protein-like 5 like
chr1_+_54911458 3.71 ENSDART00000089603
golga7ba
golgin A7 family, member Ba
chr12_-_19862912 3.59 ENSDART00000145788
shisa9a
shisa family member 9a
chr20_-_35052464 3.58 ENSDART00000037195
kif26bb
kinesin family member 26Bb
chr23_+_30859086 3.57 ENSDART00000053661
zgc:198371
zgc:198371
chr12_-_1951233 3.50 ENSDART00000005676
ENSDART00000127937
sox9a
SRY (sex determining region Y)-box 9a
chr7_-_31940590 3.49 ENSDART00000131009
bdnf
brain-derived neurotrophic factor
chr18_-_44611252 3.42 ENSDART00000173095
spred3
sprouty-related, EVH1 domain containing 3
chr10_-_26793448 3.39 ENSDART00000141955
mcf2b
MCF.2 cell line derived transforming sequence b
chr13_+_23282549 3.14 ENSDART00000101134
khdrbs2
KH domain containing, RNA binding, signal transduction associated 2
chr14_-_1987121 3.07 ENSDART00000135733
pcdh2g5
protocadherin 2 gamma 5
chr16_+_5539189 2.99 ENSDART00000178106
CR848788.2

chr12_-_16524727 2.83 ENSDART00000166645
FO704724.1

chr2_-_4642407 2.71 ENSDART00000162044
CABZ01063651.1

chr21_-_17482465 2.57 ENSDART00000004548
barhl1b
BarH-like homeobox 1b
chr23_+_38957738 2.42 ENSDART00000193480
ATP9A
ATPase phospholipid transporting 9A (putative)
chr1_+_19515228 2.31 ENSDART00000103091
clrn2
clarin 2
chr1_+_12348213 2.00 ENSDART00000144920
ENSDART00000138759
ENSDART00000067082
clta
clathrin, light chain A
chr14_-_1998501 1.68 ENSDART00000189052
pcdh2g5
protocadherin 2 gamma 5
chr23_+_38957472 1.51 ENSDART00000193836
ATP9A
ATPase phospholipid transporting 9A (putative)
chr7_+_59739164 1.36 ENSDART00000110412
gpr78b
G protein-coupled receptor 78b
chr11_-_25538341 1.08 ENSDART00000171560
si:dkey-245f22.3
si:dkey-245f22.3
chr14_-_2032753 1.05 ENSDART00000111335
pcdh2g5
protocadherin 2 gamma 5
chr14_-_1963369 0.97 ENSDART00000125521
pcdh2g5
protocadherin 2 gamma 5
chr24_+_26742226 0.85 ENSDART00000079721
ghsrb
growth hormone secretagogue receptor b
chr17_-_33552363 0.62 ENSDART00000154400
tmem121aa
transmembrane protein 121Aa
chr22_+_1751640 0.52 ENSDART00000162093
znf1169
zinc finger protein 1169
chr5_-_29750377 0.39 ENSDART00000051474
barhl1a
BarH-like homeobox 1a
chr7_+_40228422 0.24 ENSDART00000052222
ptprn2
protein tyrosine phosphatase, receptor type, N polypeptide 2
chr4_-_17391091 0.23 ENSDART00000056002
th2
tyrosine hydroxylase 2
chr24_+_6353394 0.22 ENSDART00000165118
CR352329.1

Network of associatons between targets according to the STRING database.

First level regulatory network of rest

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
11.1 44.4 GO:1990544 intracellular nucleoside transport(GO:0015859) purine nucleoside transmembrane transport(GO:0015860) purine nucleotide transport(GO:0015865) ATP transport(GO:0015867) purine ribonucleotide transport(GO:0015868) adenine nucleotide transport(GO:0051503) mitochondrial ATP transmembrane transport(GO:1990544)
5.6 101.3 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
4.7 18.7 GO:0097112 gamma-aminobutyric acid receptor clustering(GO:0097112)
4.6 23.1 GO:0070208 protein heterotrimerization(GO:0070208)
4.0 32.1 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
3.7 29.8 GO:0043092 amino acid import(GO:0043090) L-amino acid import(GO:0043092)
3.6 10.9 GO:0090278 negative regulation of peptide secretion(GO:0002792) negative regulation of peptide hormone secretion(GO:0090278)
3.2 12.9 GO:0086005 ventricular cardiac muscle cell action potential(GO:0086005)
2.5 7.6 GO:0099552 trans-synaptic signaling by lipid, modulating synaptic transmission(GO:0099552) trans-synaptic signaling by endocannabinoid, modulating synaptic transmission(GO:0099553)
2.3 30.2 GO:1990504 dense core granule exocytosis(GO:1990504)
2.3 9.3 GO:2000171 negative regulation of dendrite development(GO:2000171)
2.1 14.4 GO:0099550 trans-synaptic signalling, modulating synaptic transmission(GO:0099550)
2.0 16.0 GO:0008343 adult feeding behavior(GO:0008343)
1.7 24.4 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
1.4 7.1 GO:0003210 cardiac atrium formation(GO:0003210)
1.4 31.1 GO:0007631 feeding behavior(GO:0007631)
1.3 18.7 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
1.1 5.7 GO:0016191 synaptic vesicle uncoating(GO:0016191)
1.1 14.7 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
1.1 10.5 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
1.0 14.2 GO:0032088 negative regulation of NF-kappaB transcription factor activity(GO:0032088)
0.9 14.3 GO:0046887 positive regulation of hormone secretion(GO:0046887)
0.7 10.2 GO:0061001 regulation of dendritic spine morphogenesis(GO:0061001)
0.7 19.5 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.6 28.8 GO:0050432 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059) catecholamine secretion(GO:0050432) regulation of catecholamine secretion(GO:0050433)
0.6 3.4 GO:0010799 regulation of peptidyl-threonine phosphorylation(GO:0010799) negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
0.5 13.1 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.5 12.9 GO:0031114 regulation of microtubule depolymerization(GO:0031114)
0.5 10.0 GO:0016082 synaptic vesicle priming(GO:0016082)
0.4 3.8 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.4 3.6 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.4 9.7 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.4 10.8 GO:0050708 regulation of protein secretion(GO:0050708)
0.3 3.5 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.3 5.1 GO:0071436 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.3 8.1 GO:0033500 carbohydrate homeostasis(GO:0033500) glucose homeostasis(GO:0042593)
0.2 13.9 GO:0014065 phosphatidylinositol 3-kinase signaling(GO:0014065)
0.2 3.5 GO:0032332 positive regulation of chondrocyte differentiation(GO:0032332)
0.2 20.6 GO:0006836 neurotransmitter transport(GO:0006836)
0.2 51.4 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.2 4.0 GO:0030032 lamellipodium assembly(GO:0030032)
0.1 15.9 GO:0010506 regulation of autophagy(GO:0010506)
0.1 21.9 GO:0002040 sprouting angiogenesis(GO:0002040)
0.1 3.7 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 23.7 GO:0030334 regulation of cell migration(GO:0030334)
0.1 0.2 GO:0006585 dopamine biosynthetic process from tyrosine(GO:0006585) dopamine biosynthetic process(GO:0042416)
0.1 3.8 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)
0.1 5.6 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.1 2.0 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 13.2 GO:1904888 cranial skeletal system development(GO:1904888)
0.0 4.6 GO:0006821 chloride transport(GO:0006821)
0.0 3.1 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 5.9 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.0 17.2 GO:0015031 protein transport(GO:0015031)
0.0 3.6 GO:0007018 microtubule-based movement(GO:0007018)
0.0 9.5 GO:0007186 G-protein coupled receptor signaling pathway(GO:0007186)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
6.8 101.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
6.2 18.7 GO:0060077 inhibitory synapse(GO:0060077)
5.7 34.4 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
4.3 13.0 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
2.1 32.1 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
1.8 12.9 GO:0031045 dense core granule(GO:0031045)
1.5 30.3 GO:0032588 trans-Golgi network membrane(GO:0032588)
1.1 10.9 GO:0042583 chromaffin granule(GO:0042583)
0.8 9.7 GO:0030893 meiotic cohesin complex(GO:0030893)
0.7 30.2 GO:0098978 glutamatergic synapse(GO:0098978)
0.7 23.1 GO:1902711 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.5 12.9 GO:0001518 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.5 5.1 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.4 14.7 GO:0034707 chloride channel complex(GO:0034707)
0.4 22.6 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.2 3.7 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.2 3.6 GO:0032591 dendritic spine membrane(GO:0032591)
0.2 7.6 GO:0099634 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.2 5.6 GO:0043679 axon terminus(GO:0043679) neuron projection terminus(GO:0044306)
0.1 19.4 GO:0070382 exocytic vesicle(GO:0070382)
0.1 14.2 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 10.8 GO:0031201 SNARE complex(GO:0031201)
0.1 44.4 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 13.2 GO:0043025 neuronal cell body(GO:0043025)
0.1 15.9 GO:0014069 postsynaptic density(GO:0014069)
0.1 36.9 GO:0045202 synapse(GO:0045202)
0.1 133.6 GO:0005576 extracellular region(GO:0005576)
0.1 83.0 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 4.0 GO:0030027 lamellipodium(GO:0030027)
0.0 14.8 GO:0005730 nucleolus(GO:0005730)
0.0 3.6 GO:0005871 kinesin complex(GO:0005871)
0.0 4.0 GO:0005911 cell-cell junction(GO:0005911)
0.0 95.4 GO:0016021 integral component of membrane(GO:0016021)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
11.1 44.4 GO:0005471 ATP:ADP antiporter activity(GO:0005471)
6.2 31.1 GO:0031843 neuropeptide Y receptor binding(GO:0031841) type 2 neuropeptide Y receptor binding(GO:0031843)
5.1 101.3 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
3.2 13.0 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
2.5 32.1 GO:0005326 neurotransmitter transporter activity(GO:0005326)
2.1 29.8 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
2.0 14.3 GO:0031705 bombesin receptor binding(GO:0031705)
1.6 23.1 GO:0022851 benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)
1.6 14.7 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
1.6 12.9 GO:0019871 sodium channel inhibitor activity(GO:0019871)
1.3 11.9 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
1.3 10.5 GO:0004994 somatostatin receptor activity(GO:0004994)
1.2 40.8 GO:0005184 neuropeptide hormone activity(GO:0005184)
1.1 7.6 GO:0099530 G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
1.0 18.7 GO:0017080 sodium channel regulator activity(GO:0017080)
0.9 18.7 GO:0050811 GABA receptor binding(GO:0050811)
0.9 34.4 GO:0017075 syntaxin-1 binding(GO:0017075)
0.8 10.8 GO:0045159 myosin II binding(GO:0045159)
0.6 7.1 GO:0032036 myosin heavy chain binding(GO:0032036)
0.6 28.8 GO:0001786 phosphatidylserine binding(GO:0001786)
0.6 19.5 GO:0042162 telomeric DNA binding(GO:0042162)
0.4 5.6 GO:0031628 opioid receptor binding(GO:0031628)
0.3 3.5 GO:0005165 nerve growth factor receptor binding(GO:0005163) neurotrophin receptor binding(GO:0005165)
0.3 4.6 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.3 5.1 GO:0001671 ATPase activator activity(GO:0001671)
0.2 23.5 GO:0005179 hormone activity(GO:0005179)
0.1 3.1 GO:0008143 poly(A) binding(GO:0008143)
0.1 2.0 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 3.8 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.1 5.7 GO:0030276 clathrin binding(GO:0030276)
0.1 3.7 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 68.3 GO:0005509 calcium ion binding(GO:0005509)
0.0 8.9 GO:0015293 symporter activity(GO:0015293)
0.0 0.2 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.0 16.5 GO:0008017 microtubule binding(GO:0008017)
0.0 13.2 GO:0003682 chromatin binding(GO:0003682)
0.0 19.6 GO:0046983 protein dimerization activity(GO:0046983)
0.0 14.5 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.0 14.2 GO:0005102 receptor binding(GO:0005102)
0.0 83.8 GO:0046872 metal ion binding(GO:0046872)
0.0 3.4 GO:0019901 protein kinase binding(GO:0019901)
0.0 3.2 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 16.3 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.6 15.2 PID RAS PATHWAY Regulation of Ras family activation
0.3 9.7 PID ATM PATHWAY ATM pathway
0.2 3.8 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.1 20.3 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.1 12.9 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 2.0 PID ARF 3PATHWAY Arf1 pathway
0.1 4.0 PID ILK PATHWAY Integrin-linked kinase signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.8 15.2 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
2.0 29.8 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
1.5 23.1 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
1.3 8.9 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
1.2 11.6 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
1.1 44.4 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.8 12.9 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.8 11.9 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.3 2.0 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.3 9.7 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.3 4.0 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.2 5.6 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.2 5.7 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.2 19.5 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.1 3.8 REACTOME CIRCADIAN CLOCK Genes involved in Circadian Clock
0.1 3.9 REACTOME ION CHANNEL TRANSPORT Genes involved in Ion channel transport