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PRJEB1986: zebrafish developmental stages transcriptome

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Results for rfx1a+rfx1b

Z-value: 0.92

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Transcription factors associated with rfx1a+rfx1b

Gene Symbol Gene ID Gene Info
rfx1a
ENSDARG00000005883 regulatory factor X, 1a (influences HLA class II expression)
rfx1b
ENSDARG00000075904 regulatory factor X, 1b (influences HLA class II expression)

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
rfx1adr11_v1_chr3_-_19200571_192006510.662.1e-03Click!
rfx1bdr11_v1_chr1_-_54107321_541073210.571.1e-02Click!

Activity profile of rfx1a+rfx1b motif

Sorted Z-values of rfx1a+rfx1b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr20_-_52902693 3.03 ENSDART00000166115
ENSDART00000161050
ctsbb
cathepsin Bb
chr13_-_51952020 2.23 ENSDART00000181079
LT631676.1

chr8_-_53488832 1.88 ENSDART00000191801
chdh
choline dehydrogenase
chr8_-_5220125 1.56 ENSDART00000035676
bnip3la
BCL2 interacting protein 3 like a
chr21_-_1625976 1.38 ENSDART00000066621
vmo1b
vitelline membrane outer layer 1 homolog b
chr23_+_10469955 1.34 ENSDART00000140557
tns2a
tensin 2a
chr23_+_44665230 1.26 ENSDART00000144958
camta2
calmodulin binding transcription activator 2
chr24_-_39772045 1.19 ENSDART00000087441
GFOD1
si:ch211-276f18.2
chr16_-_9869056 1.11 ENSDART00000149312
ncalda
neurocalcin delta a
chr25_+_34407740 1.09 ENSDART00000012677
OTUD7A
si:dkey-37f18.2
chr3_-_6719232 1.06 ENSDART00000154294
atg4db
autophagy related 4D, cysteine peptidase b
chr20_+_49787584 1.02 ENSDART00000193458
ENSDART00000181511
ENSDART00000185850
ENSDART00000185613
ENSDART00000191671
CABZ01078261.1

chr11_+_43661735 0.95 ENSDART00000017912
gli2b
GLI family zinc finger 2b
chr5_-_38384289 0.94 ENSDART00000135260
mink1
misshapen-like kinase 1
chr3_+_17456428 0.93 ENSDART00000090676
ENSDART00000182082
si:ch211-210g13.5
si:ch211-210g13.5
chr19_+_43123331 0.90 ENSDART00000187836
CABZ01101996.1

chr3_+_49521106 0.90 ENSDART00000162799
crb3a
crumbs homolog 3a
chr1_+_50538839 0.90 ENSDART00000020412
pkd2
polycystic kidney disease 2
chr13_-_24717365 0.90 ENSDART00000137934
ENSDART00000003922
erlin1
ER lipid raft associated 1
chr13_-_18691041 0.90 ENSDART00000057867
sfxn3
sideroflexin 3
chr9_-_41401564 0.89 ENSDART00000059628
nab1b
NGFI-A binding protein 1b (EGR1 binding protein 1)
chr18_+_29950233 0.88 ENSDART00000146431
atmin
ATM interactor
chr17_+_34186632 0.87 ENSDART00000014306
mpp5a
membrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5)
chr23_+_21380079 0.85 ENSDART00000089379
iffo2a
intermediate filament family orphan 2a
chr22_+_438714 0.85 ENSDART00000136491
celsr2
cadherin, EGF LAG seven-pass G-type receptor 2
chr10_+_6907715 0.85 ENSDART00000041068
slc38a9
solute carrier family 38, member 9
chr23_-_12158685 0.84 ENSDART00000135035
fam217b
family with sequence similarity 217, member B
chr18_-_2727764 0.84 ENSDART00000160841
ARHGEF17
si:ch211-248g20.5
chr14_-_33481428 0.84 ENSDART00000147059
ENSDART00000140001
ENSDART00000124242
ENSDART00000164836
ENSDART00000190104
ENSDART00000186833
ENSDART00000180873
lamp2
lysosomal-associated membrane protein 2
chr13_+_48482256 0.83 ENSDART00000053332
FOXN2 (1 of many)
forkhead box N2
chr17_-_22067451 0.82 ENSDART00000156872
ttbk1b
tau tubulin kinase 1b
chr1_+_604127 0.82 ENSDART00000133165
jam2a
junctional adhesion molecule 2a
chr13_-_47556447 0.81 ENSDART00000131239
acoxl
acyl-CoA oxidase-like
chr6_+_18418651 0.81 ENSDART00000171097
ENSDART00000167798
rab11fip4b
RAB11 family interacting protein 4 (class II) b
chr21_+_43669943 0.77 ENSDART00000136025
tmlhe
trimethyllysine hydroxylase, epsilon
chr3_-_46410387 0.77 ENSDART00000156822
cdip1
cell death-inducing p53 target 1
chr15_-_43768776 0.73 ENSDART00000170398
grm5b
glutamate receptor, metabotropic 5b
chr8_-_22838364 0.73 ENSDART00000187954
ENSDART00000185368
ENSDART00000188210
magixa
MAGI family member, X-linked a
chr20_+_36682051 0.73 ENSDART00000130513
ncoa1
nuclear receptor coactivator 1
chr10_-_44482911 0.72 ENSDART00000085556
hip1ra
huntingtin interacting protein 1 related a
chr24_-_205275 0.72 ENSDART00000108762
vopp1
VOPP1, WBP1/VOPP1 family member
chr25_+_35942867 0.71 ENSDART00000066985
hsd17b2
hydroxysteroid (17-beta) dehydrogenase 2
chr20_-_7583486 0.71 ENSDART00000144729
usp24
ubiquitin specific peptidase 24
chr4_-_73520581 0.71 ENSDART00000171513
si:ch73-266f23.1
si:ch73-266f23.1
chr22_+_980290 0.70 ENSDART00000065377
def6b
differentially expressed in FDCP 6b homolog (mouse)
chr17_+_1496107 0.70 ENSDART00000187804
LO018430.1

chr20_-_35706379 0.70 ENSDART00000152847
si:dkey-30j22.1
si:dkey-30j22.1
chr13_+_13805385 0.69 ENSDART00000166859
slc4a11
solute carrier family 4, sodium borate transporter, member 11
chr3_+_49021079 0.69 ENSDART00000162012
zgc:163083
zgc:163083
chr20_-_2361226 0.69 ENSDART00000172130
EPB41L2
si:ch73-18b11.1
chr17_+_12075805 0.68 ENSDART00000155329
cnsta
consortin, connexin sorting protein a
chr18_+_50890749 0.68 ENSDART00000174109
si:ch1073-450f2.1
si:ch1073-450f2.1
chr19_+_551963 0.68 ENSDART00000110495
akap9
A kinase (PRKA) anchor protein 9
chr9_+_48415043 0.67 ENSDART00000159930
lrp2a
low density lipoprotein receptor-related protein 2a
chr18_+_50880096 0.67 ENSDART00000169782
si:ch1073-450f2.1
si:ch1073-450f2.1
chr4_+_15819728 0.66 ENSDART00000101613
lrguk
leucine-rich repeats and guanylate kinase domain containing
chr17_+_44756247 0.65 ENSDART00000153773
cipca
CLOCK-interacting pacemaker a
chr15_-_1022436 0.65 ENSDART00000156003
znf1010
zinc finger protein 1010
chr22_-_10891213 0.64 ENSDART00000145229
arhgef18b
rho/rac guanine nucleotide exchange factor (GEF) 18b
chr3_-_12026741 0.63 ENSDART00000132238
cfap70
cilia and flagella associated protein 70
chr2_-_1569250 0.61 ENSDART00000167202
dab1b
Dab, reelin signal transducer, homolog 1b (Drosophila)
chr2_+_55914699 0.61 ENSDART00000157905
atcayb
ataxia, cerebellar, Cayman type b
chr4_-_9557186 0.60 ENSDART00000150569
shank3b
SH3 and multiple ankyrin repeat domains 3b
chr8_-_36370552 0.58 ENSDART00000097932
ENSDART00000148323
si:busm1-104n07.3
si:busm1-104n07.3
chr13_+_669177 0.58 ENSDART00000190085
CU462915.1

chr21_+_3244146 0.57 ENSDART00000127740
ctif
CBP80/20-dependent translation initiation factor
chr1_+_11711503 0.56 ENSDART00000138355
si:dkey-26i13.8
si:dkey-26i13.8
chr8_-_49345388 0.56 ENSDART00000053203
plp2
proteolipid protein 2
chr6_+_13933464 0.56 ENSDART00000109144
ptprnb
protein tyrosine phosphatase, receptor type, Nb
chr18_-_50579629 0.55 ENSDART00000188252
zgc:158464
zgc:158464
chr17_+_21964472 0.55 ENSDART00000063704
ENSDART00000188904
crip3
cysteine-rich protein 3
chr6_+_612330 0.54 ENSDART00000166872
ENSDART00000191758
kynu
kynureninase
chr1_+_54683655 0.53 ENSDART00000132785
knop1
lysine-rich nucleolar protein 1
chr2_+_7192966 0.53 ENSDART00000142735
si:ch211-13f8.1
si:ch211-13f8.1
chr18_-_43884044 0.52 ENSDART00000087382
ddx6
DEAD (Asp-Glu-Ala-Asp) box helicase 6
chr15_-_47892583 0.51 ENSDART00000192584
DMWD
zmp:0000000529
chr6_-_40842768 0.51 ENSDART00000076160
mustn1a
musculoskeletal, embryonic nuclear protein 1a
chr15_-_47193564 0.51 ENSDART00000172453
LSAMP
limbic system-associated membrane protein
chr25_+_18436301 0.50 ENSDART00000056180
cep41
centrosomal protein 41
chr4_-_9579299 0.49 ENSDART00000183079
ENSDART00000192968
ENSDART00000091809
shank3b
SH3 and multiple ankyrin repeat domains 3b
chr1_+_19943803 0.47 ENSDART00000164661
apbb2b
amyloid beta (A4) precursor protein-binding, family B, member 2b
chr2_-_42960353 0.46 ENSDART00000098303
oc90
otoconin 90
chr17_-_49412313 0.46 ENSDART00000152100
mthfd1b
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b
chr22_-_36690742 0.45 ENSDART00000017188
ENSDART00000124698
ncl
nucleolin
chr21_-_32781612 0.45 ENSDART00000031028
cnot6a
CCR4-NOT transcription complex, subunit 6a
chr17_+_33296852 0.45 ENSDART00000154580
dnajc27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr6_-_37403444 0.45 ENSDART00000136314
cthl
cystathionase (cystathionine gamma-lyase), like
chr4_+_34343524 0.44 ENSDART00000171694
si:ch211-246b8.5
si:ch211-246b8.5
chr23_+_6272638 0.44 ENSDART00000190366
syt2a
synaptotagmin IIa
chr24_-_1657276 0.43 ENSDART00000168131
si:ch73-378g22.1
si:ch73-378g22.1
chr24_+_38155830 0.43 ENSDART00000152019
si:ch211-234p6.5
si:ch211-234p6.5
chr8_+_7144066 0.43 ENSDART00000146306
slc6a6a
solute carrier family 6 (neurotransmitter transporter), member 6a
chr2_-_16449504 0.43 ENSDART00000144801
atr
ATR serine/threonine kinase
chr12_+_4971515 0.43 ENSDART00000161076
arhgap27
Rho GTPase activating protein 27
chr20_-_27857676 0.43 ENSDART00000192934
syndig1l
synapse differentiation inducing 1-like
chr19_-_43639331 0.43 ENSDART00000138009
ENSDART00000086138
fam83hb
family with sequence similarity 83, member Hb
chr18_+_49411417 0.43 ENSDART00000028944
LRFN3
zmp:0000001073
chr16_+_41717313 0.42 ENSDART00000015170
ENSDART00000075937
mtdhb
metadherin b
chr5_-_38384755 0.42 ENSDART00000188573
ENSDART00000051233
mink1
misshapen-like kinase 1
chr8_-_46045172 0.41 ENSDART00000135138
si:ch211-119d14.3
si:ch211-119d14.3
chr2_+_7075220 0.41 ENSDART00000022963
cdc14aa
cell division cycle 14Aa
chr8_+_36288261 0.41 ENSDART00000191281
CU929676.1

chr9_+_48219111 0.41 ENSDART00000111225
ENSDART00000145972
ccdc173
coiled-coil domain containing 173
chr3_+_60034194 0.40 ENSDART00000189858
ENSDART00000153642
CR352258.1

chr10_-_74408 0.40 ENSDART00000100073
ENSDART00000141723
dyrk1aa
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A, a
chr13_+_31205439 0.39 ENSDART00000132326
ptpn20
protein tyrosine phosphatase, non-receptor type 20
chr4_+_20177526 0.39 ENSDART00000017947
ENSDART00000135451
ccdc146
coiled-coil domain containing 146
chr23_+_2760573 0.39 ENSDART00000129719
top1
DNA topoisomerase I
chr11_-_30352333 0.39 ENSDART00000030794
tmem169a
transmembrane protein 169a
chr13_+_36958086 0.39 ENSDART00000024386
frmd6
FERM domain containing 6
chr2_-_58183499 0.38 ENSDART00000172281
ENSDART00000186262
si:ch1073-185p12.2
si:ch1073-185p12.2
chr10_+_2807136 0.38 ENSDART00000126440
ENSDART00000131435
aebp1
AE binding protein 1
chr9_-_40873934 0.37 ENSDART00000066424
pofut2
protein O-fucosyltransferase 2
chr8_-_9570511 0.37 ENSDART00000044000
plxna3
plexin A3
chr20_-_7582936 0.37 ENSDART00000083890
usp24
ubiquitin specific peptidase 24
chr18_+_16192083 0.37 ENSDART00000133042
lrriq1
leucine-rich repeats and IQ motif containing 1
chr6_-_23931442 0.37 ENSDART00000160547
sec16b
SEC16 homolog B, endoplasmic reticulum export factor
chr20_+_30797329 0.36 ENSDART00000145066
nhsl1b
NHS-like 1b
chr11_-_44194132 0.35 ENSDART00000182954
ENSDART00000111271
CABZ01080074.1

chr4_+_77971104 0.35 ENSDART00000188609
zgc:113921
zgc:113921
chr3_-_60175470 0.35 ENSDART00000156597
si:ch73-364h19.1
si:ch73-364h19.1
chr5_+_25317061 0.35 ENSDART00000170097
trpm6
transient receptor potential cation channel, subfamily M, member 6
chr10_-_44560165 0.35 ENSDART00000181217
ENSDART00000076084
npm2b
nucleophosmin/nucleoplasmin, 2b
chr16_-_31791165 0.34 ENSDART00000148389
chd4b
chromodomain helicase DNA binding protein 4b
chr7_+_23515966 0.34 ENSDART00000186893
ENSDART00000186189
zgc:109889
zgc:109889
chr2_+_41526904 0.34 ENSDART00000127520
acvr1l
activin A receptor, type 1 like
chr8_+_25267903 0.34 ENSDART00000093090
ampd2b
adenosine monophosphate deaminase 2b
chr4_-_1801519 0.33 ENSDART00000188604
ENSDART00000135749
nudt4b
nudix (nucleoside diphosphate linked moiety X)-type motif 4b
chr2_+_33796207 0.33 ENSDART00000124647
kiss1ra
KISS1 receptor a
chr1_+_53279861 0.32 ENSDART00000035713
rnf150a
ring finger protein 150a
chr15_+_22267847 0.32 ENSDART00000110665
spa17
sperm autoantigenic protein 17
chr14_+_10596628 0.32 ENSDART00000115177
gpr174
G protein-coupled receptor 174
chr20_+_27003713 0.31 ENSDART00000153232
si:dkey-177p2.18
si:dkey-177p2.18
chr5_+_61919217 0.31 ENSDART00000097340
rsph4a
radial spoke head 4 homolog A
chr5_-_72390259 0.31 ENSDART00000172302
wbp1
WW domain binding protein 1
chr12_+_33361948 0.30 ENSDART00000124982
fasn
fatty acid synthase
chr14_+_7892021 0.30 ENSDART00000161307
ube2d2
ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)
chr13_-_14926318 0.30 ENSDART00000142785
cdc25b
cell division cycle 25B
chr22_-_16270462 0.30 ENSDART00000105681
cdc14ab
cell division cycle 14Ab
chr4_-_2545310 0.30 ENSDART00000150619
ENSDART00000140760
e2f7
E2F transcription factor 7
chr7_-_21905851 0.30 ENSDART00000111066
ENSDART00000020288
epoa
erythropoietin a
chr6_-_58901552 0.29 ENSDART00000122003
mbd6
methyl-CpG binding domain protein 6
chr25_-_21894706 0.29 ENSDART00000189158
fbxo31
F-box protein 31
chr16_-_11779508 0.29 ENSDART00000136329
ENSDART00000060145
ENSDART00000141101
pafah1b3
platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit
chr18_-_47103131 0.29 ENSDART00000188553
CABZ01039304.1

chr22_-_16270071 0.29 ENSDART00000171823
cdc14ab
cell division cycle 14Ab
chr8_-_36412936 0.28 ENSDART00000159276
si:zfos-2070c2.3
si:zfos-2070c2.3
chr19_+_2275019 0.28 ENSDART00000136138
itgb8
integrin, beta 8
chr19_-_12324514 0.28 ENSDART00000122192
ncaldb
neurocalcin delta b
chr15_+_31735931 0.27 ENSDART00000185681
ENSDART00000149137
rxfp2b
relaxin/insulin-like family peptide receptor 2b
chr2_+_13462305 0.26 ENSDART00000149309
ENSDART00000080900
cfap57
cilia and flagella associated protein 57
chr12_-_36521767 0.26 ENSDART00000110290
unc13d
unc-13 homolog D (C. elegans)
chr6_+_515181 0.25 ENSDART00000171374
CACNA1I (1 of many)
si:ch73-379f7.5
chr20_-_28642061 0.25 ENSDART00000135513
rgs6
regulator of G protein signaling 6
chr7_+_29163762 0.25 ENSDART00000173762
slc38a8b
solute carrier family 38, member 8b
chr4_+_51160367 0.24 ENSDART00000189984
znf1141
zinc finger protein 1141
chr6_-_46560207 0.24 ENSDART00000187607
kcnb1
potassium voltage-gated channel, Shab-related subfamily, member 1
chr7_-_29533127 0.24 ENSDART00000057289
anxa2b
annexin A2b
chr18_-_46763170 0.23 ENSDART00000171880
dner
delta/notch-like EGF repeat containing
chr16_+_13898399 0.23 ENSDART00000140946
si:ch211-149k23.9
si:ch211-149k23.9
chr21_+_9576176 0.23 ENSDART00000161289
ENSDART00000159899
ENSDART00000162834
mapk10
mitogen-activated protein kinase 10
chr20_-_38617766 0.23 ENSDART00000050474
slc30a2
solute carrier family 30 (zinc transporter), member 2
chr21_-_435466 0.23 ENSDART00000110297
klf4
Kruppel-like factor 4
chr2_+_59527149 0.22 ENSDART00000168568
CU861477.1

chr24_+_39186940 0.22 ENSDART00000155817
spsb3b
splA/ryanodine receptor domain and SOCS box containing 3b
chr6_+_18251140 0.22 ENSDART00000169752
ccdc40
coiled-coil domain containing 40
chr13_-_48756036 0.22 ENSDART00000035018
ENSDART00000132895
ntpcr
nucleoside-triphosphatase, cancer-related
chr13_+_12606821 0.22 ENSDART00000140096
ENSDART00000145136
metap1
methionyl aminopeptidase 1
chr7_-_50395059 0.21 ENSDART00000191150
vps33b
vacuolar protein sorting 33B
chr19_-_27588842 0.21 ENSDART00000121643
si:dkeyp-46h3.2
si:dkeyp-46h3.2
chr2_-_7696287 0.20 ENSDART00000190769
CABZ01055306.1

chr13_-_48764180 0.20 ENSDART00000167157
si:ch1073-266p11.2
si:ch1073-266p11.2
chr12_+_13405445 0.20 ENSDART00000089042
kcnh4b
potassium voltage-gated channel, subfamily H (eag-related), member 4b
chr3_+_60044780 0.20 ENSDART00000080437
zgc:113030
zgc:113030
chr5_-_69940868 0.19 ENSDART00000185924
ENSDART00000097357
ugt2a4
UDP glucuronosyltransferase 2 family, polypeptide A4
chr18_+_38191346 0.19 ENSDART00000052703
nucb2b
nucleobindin 2b
chr21_-_43606502 0.19 ENSDART00000151030
si:ch73-362m14.4
si:ch73-362m14.4
chr17_-_8173380 0.18 ENSDART00000148520
syne1b
spectrin repeat containing, nuclear envelope 1b
chr20_+_27003558 0.18 ENSDART00000125688
si:dkey-177p2.18
si:dkey-177p2.18
chr10_+_8101729 0.18 ENSDART00000138875
ENSDART00000123447
ENSDART00000185333
pstpip2
proline-serine-threonine phosphatase interacting protein 2
chr2_-_10631767 0.18 ENSDART00000190033
mtf2
metal response element binding transcription factor 2
chr4_-_12795436 0.18 ENSDART00000131026
ENSDART00000075127
b2m
beta-2-microglobulin
chr17_+_53186347 0.18 ENSDART00000155981
dph6
diphthamine biosynthesis 6
chr7_-_19999152 0.18 ENSDART00000173881
ENSDART00000100798
trip6
thyroid hormone receptor interactor 6
chr24_-_37003577 0.18 ENSDART00000137777
dnaaf3
dynein, axonemal, assembly factor 3
chr19_-_12315693 0.17 ENSDART00000151158
ncaldb
neurocalcin delta b
chr20_+_4060839 0.17 ENSDART00000178565
TRIM67
tripartite motif containing 67
chr25_-_6557854 0.17 ENSDART00000181740
cspg4
chondroitin sulfate proteoglycan 4
chr24_-_2843107 0.17 ENSDART00000165290
cyb5a
cytochrome b5 type A (microsomal)
chr7_+_38445938 0.17 ENSDART00000173467
cep89
centrosomal protein 89
chr11_+_77526 0.16 ENSDART00000193521
CABZ01072242.1

chr22_-_37565348 0.16 ENSDART00000149482
ENSDART00000104478
fxr1
fragile X mental retardation, autosomal homolog 1
chr7_+_27059330 0.16 ENSDART00000173919
plekha7b
pleckstrin homology domain containing, family A member 7b
chr19_+_2279051 0.16 ENSDART00000182103
itgb8
integrin, beta 8
chr16_-_17525322 0.16 ENSDART00000189720
clcn1b
chloride channel, voltage-sensitive 1b
chr6_+_27361978 0.16 ENSDART00000065238
crocc2
ciliary rootlet coiled-coil, rootletin family member 2
chr1_-_49498116 0.16 ENSDART00000137357
zgc:175214
zgc:175214
chr13_+_9368621 0.15 ENSDART00000109126
alms1
Alstrom syndrome protein 1
chr17_-_51651631 0.15 ENSDART00000154699
ccr6b
chemokine (C-C motif) receptor 6b
chr13_-_7767548 0.15 ENSDART00000158720
ENSDART00000121952
h2afy2
H2A histone family, member Y2

Network of associatons between targets according to the STRING database.

First level regulatory network of rfx1a+rfx1b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0019695 choline metabolic process(GO:0019695)
0.3 0.9 GO:0071498 cellular response to fluid shear stress(GO:0071498)
0.2 0.7 GO:0099552 trans-synaptic signaling by lipid, modulating synaptic transmission(GO:0099552) trans-synaptic signaling by endocannabinoid, modulating synaptic transmission(GO:0099553)
0.2 0.7 GO:0090004 positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.2 0.9 GO:0016332 establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
0.2 0.8 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.2 1.0 GO:0048855 adenohypophysis morphogenesis(GO:0048855)
0.2 0.5 GO:0097053 L-kynurenine metabolic process(GO:0097052) L-kynurenine catabolic process(GO:0097053)
0.2 1.6 GO:0097345 mitochondrial outer membrane permeabilization(GO:0097345)
0.2 0.7 GO:0042754 negative regulation of circadian rhythm(GO:0042754)
0.2 1.1 GO:0098815 postsynaptic density assembly(GO:0097107) modulation of excitatory postsynaptic potential(GO:0098815) positive regulation of excitatory postsynaptic potential(GO:2000463)
0.1 0.8 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.1 0.5 GO:0035988 chondrocyte proliferation(GO:0035988)
0.1 1.0 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.1 0.4 GO:1901207 regulation of heart looping(GO:1901207)
0.1 0.3 GO:0035124 embryonic caudal fin morphogenesis(GO:0035124)
0.1 0.2 GO:0014014 negative regulation of gliogenesis(GO:0014014)
0.1 0.6 GO:0097477 spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477)
0.1 0.8 GO:0006622 protein targeting to lysosome(GO:0006622)
0.1 0.4 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863) protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1 0.6 GO:0070293 renal absorption(GO:0070293)
0.1 0.9 GO:0071501 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.1 0.9 GO:0021754 facial nucleus development(GO:0021754)
0.1 0.3 GO:1901909 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.1 0.5 GO:0034063 stress granule assembly(GO:0034063)
0.1 0.4 GO:0009092 homoserine metabolic process(GO:0009092) cysteine biosynthetic process via cystathionine(GO:0019343) cysteine biosynthetic process(GO:0019344) transsulfuration(GO:0019346)
0.1 0.4 GO:0006004 fucose metabolic process(GO:0006004)
0.1 0.4 GO:0048755 branching morphogenesis of a nerve(GO:0048755)
0.1 0.3 GO:0045448 regulation of mitotic cell cycle, embryonic(GO:0009794) mitotic cell cycle, embryonic(GO:0045448)
0.1 0.2 GO:0030299 intestinal cholesterol absorption(GO:0030299)
0.1 0.3 GO:0032875 regulation of DNA endoreduplication(GO:0032875) positive regulation of DNA endoreduplication(GO:0032877) DNA endoreduplication(GO:0042023)
0.1 0.6 GO:0006797 polyphosphate metabolic process(GO:0006797) polyphosphate catabolic process(GO:0006798)
0.1 0.2 GO:0070084 protein initiator methionine removal(GO:0070084)
0.1 1.1 GO:0021551 central nervous system morphogenesis(GO:0021551)
0.0 0.9 GO:1902017 regulation of cilium assembly(GO:1902017)
0.0 0.2 GO:0061088 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.0 0.3 GO:0048823 nucleate erythrocyte development(GO:0048823)
0.0 0.6 GO:2000601 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 0.4 GO:0097475 motor neuron migration(GO:0097475)
0.0 0.5 GO:0009303 rRNA transcription(GO:0009303)
0.0 0.3 GO:0045740 positive regulation of DNA replication(GO:0045740)
0.0 0.9 GO:0007520 myoblast fusion(GO:0007520)
0.0 0.5 GO:0050482 icosanoid secretion(GO:0032309) arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.0 0.9 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.0 0.5 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.0 0.2 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.0 0.2 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 0.1 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)
0.0 0.5 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 1.0 GO:0032465 regulation of cytokinesis(GO:0032465)
0.0 0.3 GO:0060294 cilium movement involved in cell motility(GO:0060294)
0.0 0.3 GO:0032264 IMP salvage(GO:0032264)
0.0 0.4 GO:0006265 DNA topological change(GO:0006265)
0.0 0.1 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 0.7 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.2 GO:1901224 positive regulation of NIK/NF-kappaB signaling(GO:1901224)
0.0 0.1 GO:0060623 regulation of chromosome condensation(GO:0060623)
0.0 0.3 GO:0030819 activation of adenylate cyclase activity(GO:0007190) positive regulation of cAMP metabolic process(GO:0030816) positive regulation of cAMP biosynthetic process(GO:0030819) positive regulation of adenylate cyclase activity(GO:0045762)
0.0 0.6 GO:0006446 regulation of translational initiation(GO:0006446)
0.0 0.4 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.2 GO:0044458 motile cilium assembly(GO:0044458)
0.0 0.1 GO:0043393 regulation of protein binding(GO:0043393)
0.0 0.1 GO:0090177 establishment of planar polarity of embryonic epithelium(GO:0042249) establishment of planar polarity involved in neural tube closure(GO:0090177) regulation of establishment of planar polarity involved in neural tube closure(GO:0090178) planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.0 1.7 GO:0031098 stress-activated protein kinase signaling cascade(GO:0031098)
0.0 0.2 GO:0045824 negative regulation of innate immune response(GO:0045824)
0.0 0.4 GO:0033627 cell adhesion mediated by integrin(GO:0033627)
0.0 0.2 GO:0032094 response to food(GO:0032094)
0.0 0.1 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.1 GO:0072091 regulation of stem cell proliferation(GO:0072091)
0.0 0.4 GO:0072348 sulfur compound transport(GO:0072348)
0.0 0.9 GO:1990542 mitochondrial transmembrane transport(GO:1990542)
0.0 0.4 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.1 GO:0035721 intraciliary retrograde transport(GO:0035721)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0031310 integral component of vacuolar membrane(GO:0031166) intrinsic component of vacuolar membrane(GO:0031310)
0.2 1.0 GO:1902636 kinociliary basal body(GO:1902636)
0.1 0.3 GO:0001534 radial spoke(GO:0001534)
0.1 0.3 GO:0010369 chromocenter(GO:0010369)
0.1 0.4 GO:0042584 chromaffin granule membrane(GO:0042584)
0.1 1.1 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 0.3 GO:0070724 BMP receptor complex(GO:0070724)
0.1 0.5 GO:0031526 brush border membrane(GO:0031526)
0.1 0.6 GO:0099634 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.0 0.2 GO:0033263 CORVET complex(GO:0033263)
0.0 0.2 GO:1902737 dendritic spine neck(GO:0044326) dendritic filopodium(GO:1902737)
0.0 0.9 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.4 GO:0045095 keratin filament(GO:0045095)
0.0 0.5 GO:0031209 SCAR complex(GO:0031209)
0.0 0.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 1.3 GO:0098636 protein complex involved in cell adhesion(GO:0098636)
0.0 0.2 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.8 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.4 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.4 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.2 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.9 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.1 GO:0031332 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0 0.1 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 0.4 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 1.6 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 1.6 GO:0016324 apical plasma membrane(GO:0016324)
0.0 0.2 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 3.3 GO:0005764 lysosome(GO:0005764)
0.0 1.1 GO:0008328 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0 0.2 GO:0005640 nuclear outer membrane(GO:0005640)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.2 0.7 GO:0071253 connexin binding(GO:0071253)
0.2 0.5 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.2 0.8 GO:0003997 acyl-CoA oxidase activity(GO:0003997)
0.2 1.1 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.1 0.9 GO:0022889 serine transmembrane transporter activity(GO:0022889)
0.1 0.7 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 0.5 GO:0016823 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.1 0.9 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.1 0.7 GO:0099530 G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.1 0.3 GO:0005128 erythropoietin receptor binding(GO:0005128)
0.1 0.7 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.1 0.3 GO:0000298 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.1 0.7 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1 0.5 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.1 0.6 GO:0008494 translation activator activity(GO:0008494)
0.1 0.9 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.1 0.5 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 0.6 GO:0004309 exopolyphosphatase activity(GO:0004309)
0.0 0.3 GO:0001130 bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding(GO:0001130) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217)
0.0 0.5 GO:0070739 protein-glutamic acid ligase activity(GO:0070739) tubulin-glutamic acid ligase activity(GO:0070740)
0.0 0.8 GO:0031267 small GTPase binding(GO:0031267)
0.0 0.7 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.0 0.3 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.4 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0 0.4 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.0 0.5 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.3 GO:0030332 cyclin binding(GO:0030332)
0.0 0.3 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.4 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.9 GO:0004629 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.0 3.9 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.4 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.0 0.2 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.1 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.0 0.5 GO:0004623 phospholipase A2 activity(GO:0004623)
0.0 0.5 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.1 GO:0042609 CD4 receptor binding(GO:0042609)
0.0 0.2 GO:0004859 phospholipase inhibitor activity(GO:0004859) lipase inhibitor activity(GO:0055102)
0.0 0.9 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.1 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.0 1.9 GO:0050660 flavin adenine dinucleotide binding(GO:0050660)
0.0 0.1 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.1 GO:0035198 miRNA binding(GO:0035198)
0.0 0.4 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.4 GO:1901682 sulfur compound transmembrane transporter activity(GO:1901682)
0.0 0.8 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.0 0.2 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 1.0 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.3 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.7 GO:0042562 hormone binding(GO:0042562)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.4 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.4 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.3 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.8 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.8 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.4 PID AURORA B PATHWAY Aurora B signaling
0.0 0.2 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 0.4 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.5 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.4 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.7 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.2 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.5 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.3 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.2 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.3 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.2 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.8 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.3 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.2 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.2 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.8 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.2 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.5 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes