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PRJEB1986: zebrafish developmental stages transcriptome
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Results for si:dkey-149i17.7_zic1
Z-value: 1.24
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Transcription factors associated with si:dkey-149i17.7_zic1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| zic1 | dr11_v1_chr24_-_4973765_4973765 | -0.33 | 1.7e-01 | Click! |
| si:dkey-149i17.7 | dr11_v1_chr2_+_24885987_24885987 | 0.12 | 6.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr25_+_37285737 Show fit | 4.13 |
ENSDART00000126879
|
transmembrane p24 trafficking protein 6 |
|
| chr20_+_35473288 Show fit | 4.00 |
ENSDART00000047195
|
meprin A, alpha (PABA peptide hydrolase), tandem duplicate 1 |
|
| chr10_-_2526526 Show fit | 3.92 |
ENSDART00000191726
ENSDART00000192767 |
|
|
| chr8_-_20838342 Show fit | 3.84 |
ENSDART00000141345
|
si:ch211-133l5.7 |
|
| chr18_+_49411417 Show fit | 3.65 |
ENSDART00000028944
|
zmp:0000001073 |
|
| chr4_-_1324141 Show fit | 3.59 |
ENSDART00000180720
|
pleiotrophin |
|
| chr20_-_43775495 Show fit | 3.49 |
ENSDART00000100610
ENSDART00000149001 ENSDART00000148809 ENSDART00000100608 |
matrilin 3a |
|
| chr9_-_22158784 Show fit | 3.19 |
ENSDART00000167850
|
crystallin, gamma M2d14 |
|
| chr12_+_48634927 Show fit | 2.90 |
ENSDART00000168441
|
zgc:165653 |
|
| chr14_-_51855047 Show fit | 2.85 |
ENSDART00000088912
|
complexin 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of si:dkey-149i17.7_zic1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.2 | GO:0046839 | phospholipid dephosphorylation(GO:0046839) |
| 0.2 | 5.0 | GO:0007274 | neuromuscular synaptic transmission(GO:0007274) |
| 0.1 | 4.8 | GO:0007030 | Golgi organization(GO:0007030) |
| 0.3 | 4.6 | GO:0070328 | acylglycerol homeostasis(GO:0055090) triglyceride homeostasis(GO:0070328) |
| 0.0 | 3.7 | GO:0002088 | lens development in camera-type eye(GO:0002088) |
| 0.1 | 3.3 | GO:0051781 | positive regulation of cell division(GO:0051781) |
| 0.0 | 2.4 | GO:0051260 | protein homooligomerization(GO:0051260) |
| 0.8 | 2.3 | GO:0015695 | organic cation transport(GO:0015695) |
| 0.6 | 2.3 | GO:0018171 | peptidyl-cysteine oxidation(GO:0018171) |
| 0.1 | 2.1 | GO:0043652 | engulfment of apoptotic cell(GO:0043652) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.1 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.2 | 2.5 | GO:0000815 | ESCRT III complex(GO:0000815) |
| 0.1 | 2.1 | GO:0048788 | cytoskeleton of presynaptic active zone(GO:0048788) |
| 0.0 | 2.1 | GO:0016459 | myosin complex(GO:0016459) |
| 0.1 | 1.8 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.0 | 1.8 | GO:0005901 | caveola(GO:0005901) plasma membrane raft(GO:0044853) |
| 0.1 | 1.6 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.1 | 1.6 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.2 | 1.5 | GO:0005854 | nascent polypeptide-associated complex(GO:0005854) |
| 0.1 | 1.5 | GO:0044298 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.2 | GO:0042577 | lipid phosphatase activity(GO:0042577) |
| 0.1 | 4.9 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.9 | 4.6 | GO:0070644 | vitamin D response element binding(GO:0070644) |
| 0.0 | 4.0 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.3 | 3.3 | GO:0015101 | organic cation transmembrane transporter activity(GO:0015101) |
| 0.0 | 3.2 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.3 | 2.3 | GO:0016972 | thiol oxidase activity(GO:0016972) |
| 0.0 | 2.3 | GO:0008201 | heparin binding(GO:0008201) |
| 0.0 | 2.2 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.3 | 2.1 | GO:0004743 | pyruvate kinase activity(GO:0004743) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.6 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.2 | 3.6 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.4 | 2.2 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.1 | 1.9 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 1.8 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 1.3 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 1.1 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.0 | 1.0 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 1.0 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 1.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.6 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 4.2 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 3.5 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.2 | 2.8 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.3 | 2.7 | REACTOME REGULATION OF IFNA SIGNALING | Genes involved in Regulation of IFNA signaling |
| 0.1 | 2.4 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.8 | 2.3 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.1 | 2.0 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.1 | 1.6 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.1 | 1.0 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |