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PRJEB1986: zebrafish developmental stages transcriptome
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Results for si:dkey-43p13.5+uncx
Z-value: 1.19
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Transcription factors associated with si:dkey-43p13.5+uncx
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| si:dkey-43p13.5 | dr11_v1_chr3_+_43086548_43086548 | 0.77 | 1.0e-04 | Click! |
| uncx | dr11_v1_chr3_-_43356082_43356082 | 0.18 | 4.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_55248496 Show fit | 4.10 |
ENSDART00000098615
|
nanos homolog 3 |
|
| chr25_+_14507567 Show fit | 4.03 |
ENSDART00000015681
|
developing brain homeobox 1b |
|
| chr16_+_29509133 Show fit | 3.95 |
ENSDART00000112116
|
cathepsin S, ortholog2, tandem duplicate 1 |
|
| chr19_+_15440841 Show fit | 3.47 |
ENSDART00000182329
|
lin-28 homolog A (C. elegans) |
|
| chr11_-_35171768 Show fit | 3.24 |
ENSDART00000192896
|
TRAF-interacting protein |
|
| chr24_+_38301080 Show fit | 3.22 |
ENSDART00000105672
|
myosin binding protein C, fast type b |
|
| chr16_+_54209504 Show fit | 3.07 |
ENSDART00000020033
|
X-ray repair complementing defective repair in Chinese hamster cells 1 |
|
| chr17_-_16422654 Show fit | 3.05 |
ENSDART00000150149
|
tyrosyl-DNA phosphodiesterase 1 |
|
| chr19_+_15441022 Show fit | 2.99 |
ENSDART00000098970
ENSDART00000140276 |
lin-28 homolog A (C. elegans) |
|
| chr8_+_30452945 Show fit | 2.91 |
ENSDART00000062303
|
forkhead box D5 |
Network of associatons between targets according to the STRING database.
First level regulatory network of si:dkey-43p13.5+uncx
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.4 | GO:0008380 | RNA splicing(GO:0008380) |
| 1.2 | 6.1 | GO:0000012 | single strand break repair(GO:0000012) |
| 0.0 | 5.7 | GO:0043066 | negative regulation of apoptotic process(GO:0043066) |
| 0.2 | 5.6 | GO:0000266 | mitochondrial fission(GO:0000266) |
| 0.2 | 4.7 | GO:0020027 | hemoglobin metabolic process(GO:0020027) |
| 1.0 | 4.1 | GO:0030718 | germ-line stem cell population maintenance(GO:0030718) |
| 0.2 | 4.1 | GO:0006306 | DNA alkylation(GO:0006305) DNA methylation(GO:0006306) |
| 0.2 | 3.8 | GO:0032525 | somite rostral/caudal axis specification(GO:0032525) |
| 0.1 | 3.7 | GO:0006515 | misfolded or incompletely synthesized protein catabolic process(GO:0006515) |
| 0.0 | 3.6 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 65.1 | GO:0005634 | nucleus(GO:0005634) |
| 0.2 | 5.7 | GO:0043186 | P granule(GO:0043186) |
| 0.1 | 5.1 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 0.0 | 4.7 | GO:0005730 | nucleolus(GO:0005730) |
| 0.0 | 4.6 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 4.1 | GO:0005694 | chromosome(GO:0005694) |
| 0.1 | 3.6 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 3.6 | GO:0031966 | mitochondrial membrane(GO:0031966) |
| 0.0 | 3.5 | GO:0070160 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 0.1 | 3.0 | GO:0090568 | nuclear transcriptional repressor complex(GO:0090568) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 35.6 | GO:0001071 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.1 | 6.5 | GO:0003724 | RNA helicase activity(GO:0003724) |
| 0.4 | 5.8 | GO:0003886 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) |
| 0.1 | 5.2 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 0.2 | 4.1 | GO:0009982 | pseudouridine synthase activity(GO:0009982) |
| 0.0 | 3.4 | GO:0042802 | identical protein binding(GO:0042802) |
| 0.1 | 3.3 | GO:0042826 | histone deacetylase binding(GO:0042826) |
| 0.4 | 3.2 | GO:0043515 | kinetochore binding(GO:0043515) |
| 1.0 | 3.1 | GO:0070259 | tyrosyl-DNA phosphodiesterase activity(GO:0070259) |
| 0.6 | 3.1 | GO:0009374 | biotin binding(GO:0009374) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.2 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 5.5 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 5.1 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.0 | 3.4 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 2.9 | ST GA13 PATHWAY | G alpha 13 Pathway |
| 0.0 | 2.1 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 2.0 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
| 0.0 | 2.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 1.8 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 1.7 | PID P73PATHWAY | p73 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.0 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.2 | 5.7 | REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX | Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex |
| 0.1 | 5.3 | REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | Genes involved in Vif-mediated degradation of APOBEC3G |
| 0.1 | 4.1 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.1 | 3.4 | REACTOME DOUBLE STRAND BREAK REPAIR | Genes involved in Double-Strand Break Repair |
| 0.0 | 3.2 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.2 | 3.1 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.2 | 3.1 | REACTOME RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway |
| 0.1 | 3.0 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 2.4 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |