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PRJEB1986: zebrafish developmental stages transcriptome

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Results for smad3a+smad3b

Z-value: 0.73

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Transcription factors associated with smad3a+smad3b

Gene Symbol Gene ID Gene Info
smad3b
ENSDARG00000010207 SMAD family member 3b
smad3a
ENSDARG00000036096 SMAD family member 3a
smad3a
ENSDARG00000117146 SMAD family member 3a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
smad3bdr11_v1_chr18_+_19772874_19772874-0.615.1e-03Click!
smad3adr11_v1_chr7_-_34149263_34149263-0.223.7e-01Click!

Activity profile of smad3a+smad3b motif

Sorted Z-values of smad3a+smad3b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_16949391 3.23 ENSDART00000152635
zgc:174153
zgc:174153
chr5_+_24305877 3.14 ENSDART00000144226
ctsll
cathepsin L, like
chr3_-_58644920 1.61 ENSDART00000155953
dhrs7ca
dehydrogenase/reductase (SDR family) member 7Ca
chr21_+_20903244 1.53 ENSDART00000186193
c7b
complement component 7b
chr5_+_22459087 1.49 ENSDART00000134781
BX546499.1

chr2_-_20599315 1.44 ENSDART00000114199
si:ch211-267e7.3
si:ch211-267e7.3
chr12_-_21681509 1.39 ENSDART00000112726
eme1
essential meiotic structure-specific endonuclease 1
chr8_-_13541514 1.38 ENSDART00000063834
zgc:86586
zgc:86586
chr4_+_15944245 1.34 ENSDART00000134594
si:dkey-117n7.3
si:dkey-117n7.3
chr1_+_47178529 1.10 ENSDART00000158432
ENSDART00000074450
ENSDART00000137448
morc3b
MORC family CW-type zinc finger 3b
chr8_-_37043900 1.09 ENSDART00000139567
renbp
renin binding protein
chr25_-_35956344 1.07 ENSDART00000066987
mphosph6
M-phase phosphoprotein 6
chr8_-_13735572 0.98 ENSDART00000139642
si:dkey-258f14.7
si:dkey-258f14.7
chr13_+_10023256 0.96 ENSDART00000110035
srbd1
S1 RNA binding domain 1
chr2_-_59265521 0.95 ENSDART00000146341
ENSDART00000097799
ftr33
finTRIM family, member 33
chr4_-_64141714 0.94 ENSDART00000128628
BX914205.3

chr3_-_9444749 0.94 ENSDART00000182191
FO904885.3

chr19_-_10207103 0.92 ENSDART00000151629
znf865
zinc finger protein 865
chr9_-_41153896 0.92 ENSDART00000059667
wdr75
WD repeat domain 75
chr3_-_28872756 0.92 ENSDART00000138840
eef2kmt
eukaryotic elongation factor 2 lysine methyltransferase
chr4_-_11577253 0.91 ENSDART00000144452
net1
neuroepithelial cell transforming 1
chr22_+_14836291 0.90 ENSDART00000122740
gtpbp1l
GTP binding protein 1, like
chr1_+_21731382 0.90 ENSDART00000054395
pax5
paired box 5
chr25_-_16552135 0.90 ENSDART00000125836
si:ch211-266k8.4
si:ch211-266k8.4
chr11_+_25010491 0.85 ENSDART00000167285
zgc:92107
zgc:92107
chr23_-_21463788 0.82 ENSDART00000079265
her4.4
hairy-related 4, tandem duplicate 4
chr10_+_8875195 0.82 ENSDART00000141045
itga2.3
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor), tandem duplicate 3
chr9_-_7378566 0.82 ENSDART00000144003
slc23a3
solute carrier family 23, member 3
chr2_-_59157790 0.78 ENSDART00000192303
ENSDART00000159362
ftr32
finTRIM family, member 32
chr24_+_9744012 0.78 ENSDART00000129656
tmem108
transmembrane protein 108
chr13_-_21650404 0.77 ENSDART00000078352
tspan14
tetraspanin 14
chr14_-_25095808 0.77 ENSDART00000184244
matr3l1.1
matrin 3-like 1.1
chr3_+_13603272 0.76 ENSDART00000185084
hspbp1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr4_-_30440116 0.73 ENSDART00000159935
si:dkey-199m13.5
si:dkey-199m13.5
chr12_-_17479078 0.70 ENSDART00000079115
papss2b
3'-phosphoadenosine 5'-phosphosulfate synthase 2b
chr3_-_10779777 0.69 ENSDART00000153911
znf1004
zinc finger protein 1004
chr1_-_52494122 0.68 ENSDART00000131407
acy3.2
aspartoacylase (aminocyclase) 3, tandem duplicate 2
chr19_-_8962884 0.68 ENSDART00000172582
ENSDART00000104657
mrps21
mitochondrial ribosomal protein S21
chr16_+_26706519 0.68 ENSDART00000142706
virma
vir like m6A methyltransferase associated
chr20_+_35282682 0.67 ENSDART00000187199
fam49a
family with sequence similarity 49, member A
chr21_-_26071773 0.66 ENSDART00000141382
rab34b
RAB34, member RAS oncogene family b
chr20_-_2619316 0.66 ENSDART00000185777
bub1
BUB1 mitotic checkpoint serine/threonine kinase
chr13_+_21677767 0.66 ENSDART00000165166
mtg1
mitochondrial ribosome-associated GTPase 1
chr19_-_15281996 0.66 ENSDART00000103784
edn2
endothelin 2
chr19_-_42503143 0.65 ENSDART00000007642
zgc:110239
zgc:110239
chr17_-_45386546 0.65 ENSDART00000182647
tmem206
transmembrane protein 206
chr23_+_21455152 0.65 ENSDART00000158511
ENSDART00000161321
ENSDART00000160731
ENSDART00000137573
her4.2
hairy-related 4, tandem duplicate 2
chr25_-_2081371 0.63 ENSDART00000104915
ENSDART00000156925
wnt7bb
wingless-type MMTV integration site family, member 7Bb
chr4_-_25812329 0.63 ENSDART00000146658
tmcc3
transmembrane and coiled-coil domain family 3
chr1_-_57172294 0.63 ENSDART00000063774
rac1l
Rac family small GTPase 1, like
chr2_-_59376399 0.62 ENSDART00000137134
ftr38
finTRIM family, member 38
chr5_-_31857593 0.61 ENSDART00000191650
ENSDART00000183731
pkn3
protein kinase N3
chr1_-_59130383 0.61 ENSDART00000171552
FP015850.1

chr22_+_36582963 0.60 ENSDART00000132181
armc9
armadillo repeat containing 9
chr19_+_627899 0.59 ENSDART00000148508
tert
telomerase reverse transcriptase
chr16_-_32204470 0.59 ENSDART00000143928
rwdd1
RWD domain containing 1
chr6_-_43283122 0.58 ENSDART00000186022
frmd4ba
FERM domain containing 4Ba
chr16_-_32006737 0.57 ENSDART00000184813
ENSDART00000179827
gstk4
glutathione S-transferase kappa 4
chr5_+_62723233 0.57 ENSDART00000183718
nanos2
nanos homolog 2
chr20_+_25711718 0.56 ENSDART00000033436
cep135
centrosomal protein 135
chr16_+_15114645 0.56 ENSDART00000158483
mtbp
MDM2 binding protein
chr17_-_27273296 0.55 ENSDART00000077087
id3
inhibitor of DNA binding 3
chr6_+_37623693 0.55 ENSDART00000144812
ENSDART00000182709
tubgcp5
tubulin, gamma complex associated protein 5
chr5_+_4806851 0.55 ENSDART00000067599
angptl2a
angiopoietin-like 2a
chr6_-_8498676 0.54 ENSDART00000148627
pglyrp2
peptidoglycan recognition protein 2
chr13_+_33298338 0.54 ENSDART00000131892
ENSDART00000143895
iqcc
IQ motif containing C
chr7_-_58244220 0.52 ENSDART00000180450
unm_hu7910
un-named hu7910
chr5_-_15283509 0.51 ENSDART00000052712
gnb1l
guanine nucleotide binding protein (G protein), beta polypeptide 1-like
chr5_+_13394543 0.51 ENSDART00000051669
ENSDART00000135921
tctn2
tectonic family member 2
chr22_-_17499513 0.51 ENSDART00000105460
si:ch211-197g15.6
si:ch211-197g15.6
chr12_+_27061720 0.50 ENSDART00000153426
srcap
Snf2-related CREBBP activator protein
chr14_+_38786298 0.49 ENSDART00000164440
si:ch211-195b11.3
si:ch211-195b11.3
chr11_+_30306606 0.49 ENSDART00000128276
ENSDART00000190222
ugt1b4
UDP glucuronosyltransferase 1 family, polypeptide B4
chr23_+_13928346 0.49 ENSDART00000155326
si:dkey-90a13.10
si:dkey-90a13.10
chr16_+_14249546 0.49 ENSDART00000059967
polr3c
polymerase (RNA) III (DNA directed) polypeptide C
chr25_-_29415369 0.48 ENSDART00000110774
ENSDART00000019183
ugt5a2
ugt5a1
UDP glucuronosyltransferase 5 family, polypeptide A2
UDP glucuronosyltransferase 5 family, polypeptide A1
chr11_+_45448212 0.45 ENSDART00000173341
sos1
son of sevenless homolog 1 (Drosophila)
chr3_+_34120191 0.45 ENSDART00000020017
ENSDART00000151700
aldh3b1
aldehyde dehydrogenase 3 family, member B1
chr3_-_4501026 0.45 ENSDART00000163052
zgc:162198
zgc:162198
chr7_+_21180747 0.45 ENSDART00000185543
serpinh2
serine (or cysteine) peptidase inhibitor, clade H, member 2
chr5_-_24124118 0.45 ENSDART00000051550
capga
capping protein (actin filament), gelsolin-like a
chr10_+_36441124 0.44 ENSDART00000185626
uspl1
ubiquitin specific peptidase like 1
chr11_-_23332592 0.43 ENSDART00000125024
golt1a
golgi transport 1A
chr21_-_27362938 0.43 ENSDART00000131297
rin1a
Ras and Rab interactor 1a
chr5_+_33488860 0.43 ENSDART00000135571
si:dkey-238j22.1
si:dkey-238j22.1
chr18_+_50961953 0.42 ENSDART00000158768
ppfia1
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
chr19_-_438337 0.42 ENSDART00000127985
MTERF1
mitochondrial transcription termination factor 1
chr17_+_10578823 0.42 ENSDART00000134610
mgaa
MGA, MAX dimerization protein a
chr11_+_15890984 0.42 ENSDART00000158433
pank4
pantothenate kinase 4
chr12_-_3978306 0.42 ENSDART00000149473
ENSDART00000114857
ppp4cb
protein phosphatase 4, catalytic subunit b
chr17_-_45386823 0.41 ENSDART00000156002
tmem206
transmembrane protein 206
chr8_+_25893071 0.41 ENSDART00000078161
tmem115
transmembrane protein 115
chr12_-_18560500 0.41 ENSDART00000078172
bricd5
BRICHOS domain containing 5
chr16_-_9449712 0.41 ENSDART00000136522
prpf3
PRP3 pre-mRNA processing factor 3 homolog (yeast)
chr8_+_50150834 0.40 ENSDART00000056074
entpd4
ectonucleoside triphosphate diphosphohydrolase 4
chr24_+_29912509 0.40 ENSDART00000168422
frrs1b
ferric-chelate reductase 1b
chr12_-_33805366 0.40 ENSDART00000030566
galk1
galactokinase 1
chr23_-_26880623 0.40 ENSDART00000038491
adcy6b
adenylate cyclase 6b
chr20_-_4883673 0.40 ENSDART00000145540
ENSDART00000053877
zdhhc14
zinc finger, DHHC-type containing 14
chr21_+_33249478 0.40 ENSDART00000169972
si:ch211-151g22.1
si:ch211-151g22.1
chr14_-_30983011 0.39 ENSDART00000014095
rap2c
RAP2C, member of RAS oncogene family
chr25_+_36315127 0.39 ENSDART00000191984
zgc:165555
zgc:165555
chr4_-_11737939 0.39 ENSDART00000150299
podxl
podocalyxin-like
chr22_-_28373698 0.38 ENSDART00000157592
si:ch211-213c4.5
si:ch211-213c4.5
chr4_-_76488581 0.36 ENSDART00000174291
ftr51
finTRIM family, member 51
chr22_-_10591876 0.36 ENSDART00000105846
si:dkey-42i9.8
si:dkey-42i9.8
chr6_-_8498908 0.36 ENSDART00000149222
pglyrp2
peptidoglycan recognition protein 2
chr11_+_30310170 0.36 ENSDART00000127797
ugt1b3
UDP glucuronosyltransferase 1 family, polypeptide B3
chr23_-_21453614 0.35 ENSDART00000079274
her4.1
hairy-related 4, tandem duplicate 1
chr15_-_18218227 0.35 ENSDART00000156332
btr21
bloodthirsty-related gene family, member 21
chr13_+_2830574 0.35 ENSDART00000138143
si:ch211-233m11.1
si:ch211-233m11.1
chr11_-_8208464 0.35 ENSDART00000161283
pimr203
Pim proto-oncogene, serine/threonine kinase, related 203
chr22_+_1526040 0.34 ENSDART00000164089
ENSDART00000159126
si:ch211-255f4.6
si:ch211-255f4.6
chr2_-_59285407 0.34 ENSDART00000181616
ftr34
finTRIM family, member 34
chr3_-_4591643 0.33 ENSDART00000138144
ftr50
finTRIM family, member 50
chr23_-_27442544 0.33 ENSDART00000019521
dip2ba
disco-interacting protein 2 homolog Ba
chr16_-_17699111 0.33 ENSDART00000108581
si:dkey-17m8.1
si:dkey-17m8.1
chr24_-_6628359 0.32 ENSDART00000169731
arhgap21a
Rho GTPase activating protein 21a
chr20_+_17581881 0.32 ENSDART00000182832
cdh2
cadherin 2, type 1, N-cadherin (neuronal)
chr7_+_29890292 0.30 ENSDART00000170403
ENSDART00000168600
tln2a
talin 2a
chr10_+_25982212 0.30 ENSDART00000128292
ENSDART00000108808
frem2a
Fras1 related extracellular matrix protein 2a
chr5_-_31716713 0.30 ENSDART00000131443
dpm2
dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
chr25_-_35126024 0.30 ENSDART00000185109
HIST1H4I
zgc:165555
chr1_-_29761086 0.30 ENSDART00000136760
alg11
asparagine-linked glycosylation 11 (alpha-1,2-mannosyltransferase)
chr14_+_2487672 0.29 ENSDART00000170629
ENSDART00000123063
fgf18a
fibroblast growth factor 18a
chr20_-_1454131 0.29 ENSDART00000138059
ptprk
protein tyrosine phosphatase, receptor type, K
chr7_-_5608678 0.29 ENSDART00000138572
si:ch211-165f21.2
si:ch211-165f21.2
chr8_-_23194408 0.28 ENSDART00000141090
si:ch211-196c10.15
si:ch211-196c10.15
chr9_+_29616854 0.28 ENSDART00000033902
ENSDART00000143493
phf11
PHD finger protein 11
chr9_-_41818760 0.28 ENSDART00000140601
si:dkeyp-30e7.2
si:dkeyp-30e7.2
chr23_-_18567088 0.27 ENSDART00000192371
sephs2
selenophosphate synthetase 2
chr23_+_36052944 0.27 ENSDART00000103149
hoxc13a
homeobox C13a
chr2_+_47927026 0.27 ENSDART00000143023
ftr25
finTRIM family, member 25
chr10_+_5268054 0.26 ENSDART00000114491
ror2
receptor tyrosine kinase-like orphan receptor 2
chr3_+_24190207 0.26 ENSDART00000034762
prr15la
proline rich 15-like a
chr5_+_17780475 0.26 ENSDART00000110783
ENSDART00000115227
chfr
checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
chr2_-_7605121 0.25 ENSDART00000182099
CABZ01021599.1

chr6_-_39649504 0.25 ENSDART00000179960
ENSDART00000190951
larp4ab
La ribonucleoprotein domain family, member 4Ab
chr4_-_73227710 0.25 ENSDART00000193165
LO018260.3

chr18_-_7454422 0.25 ENSDART00000124709
pdp2
putative pyruvate dehydrogenase phosphatase isoenzyme 2
chr12_+_46386983 0.25 ENSDART00000183982
BX005305.3
Danio rerio legumain (LOC100005356), mRNA.
chr9_-_21369765 0.25 ENSDART00000132032
ift88
intraflagellar transport 88 homolog
chr9_-_16218097 0.24 ENSDART00000190503
myo1b
myosin IB
chr5_+_50371509 0.24 ENSDART00000167163
slf1
SMC5-SMC6 complex localization factor 1
chr3_-_48980319 0.24 ENSDART00000165319
ftr42
finTRIM family, member 42
chr22_+_661711 0.23 ENSDART00000113795
elf3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr8_+_23194212 0.23 ENSDART00000028946
ENSDART00000186842
ENSDART00000137815
ENSDART00000136914
ENSDART00000144855
ENSDART00000182689
tpd52l2a
tumor protein D52-like 2a
chr24_-_17400472 0.23 ENSDART00000024691
cul1b
cullin 1b
chr1_+_23784905 0.23 ENSDART00000171951
ENSDART00000188521
ENSDART00000183029
ENSDART00000187183
slit2
slit homolog 2 (Drosophila)
chr1_-_59139599 0.23 ENSDART00000152233
si:ch1073-110a20.3
si:ch1073-110a20.3
chr5_+_63390315 0.22 ENSDART00000124616
rab14
RAB14, member RAS oncogene family
chr14_-_40797117 0.22 ENSDART00000122369
elf1
E74-like ETS transcription factor 1
chr22_+_8489400 0.21 ENSDART00000129119
CABZ01046407.1

chr9_-_16853462 0.21 ENSDART00000160273
CT573248.2

chr15_+_38007237 0.21 ENSDART00000182271
CR944667.2

chr15_-_25556227 0.21 ENSDART00000156445
mmp20a
matrix metallopeptidase 20a (enamelysin)
chr15_-_41450823 0.20 ENSDART00000183327
nlrc9
NLR family CARD domain containing 9
chr7_-_6100716 0.20 ENSDART00000173003
si:cabz01036006.1
si:cabz01036006.1
chr21_+_25533908 0.19 ENSDART00000185225
nlrc3l1
NLR family, CARD domain containing 3-like 1
chr5_+_13385837 0.18 ENSDART00000191190
ccl19a.1
chemokine (C-C motif) ligand 19a, tandem duplicate 1
chr4_+_16787488 0.18 ENSDART00000143006
golt1ba
golgi transport 1Ba
chr2_+_25560556 0.18 ENSDART00000133623
pld1a
phospholipase D1a
chr3_-_2091029 0.18 ENSDART00000141464
si:dkey-88j15.4
si:dkey-88j15.4
chr1_-_43920576 0.18 ENSDART00000191914
scpp7
secretory calcium-binding phosphoprotein 7
chr7_+_24523017 0.18 ENSDART00000077047
btr09
bloodthirsty-related gene family, member 9
chr15_-_5203371 0.17 ENSDART00000141582
or128-8
odorant receptor, family E, subfamily 128, member 8
chr15_+_2500510 0.17 ENSDART00000180329
wdr53
WD repeat domain 53
chr5_+_38685089 0.17 ENSDART00000139743
si:dkey-58f10.10
si:dkey-58f10.10
chr2_-_47904043 0.16 ENSDART00000185328
ENSDART00000126740
ftr22
finTRIM family, member 22
chr5_+_71999996 0.16 ENSDART00000179933
ENSDART00000187070
PLPP7 (1 of many)
phospholipid phosphatase 7 (inactive)
chr24_-_37698796 0.16 ENSDART00000172178
si:ch211-231f6.6
si:ch211-231f6.6
chr21_-_17603182 0.15 ENSDART00000020048
ENSDART00000177270
gsna
gelsolin a
chr23_-_35694461 0.15 ENSDART00000185884
tuba1c
tubulin, alpha 1c
chr22_+_19478140 0.15 ENSDART00000135291
ENSDART00000136576
si:dkey-78l4.8
si:dkey-78l4.8
chr13_-_46899329 0.14 ENSDART00000181699
slc29a1a
solute carrier family 29 (equilibrative nucleoside transporter), member 1a
chr18_-_26715655 0.14 ENSDART00000181497
malt3
MALT paracaspase 3
chr20_-_29683754 0.14 ENSDART00000130599
ENSDART00000015928
ENSDART00000131219
si:ch211-195d17.2
si:ch211-195d17.2
chr1_-_45889820 0.14 ENSDART00000144735
pnpla6
patatin-like phospholipase domain containing 6
chr21_+_25533531 0.13 ENSDART00000134052
nlrc3l1
NLR family, CARD domain containing 3-like 1
chr19_-_24218942 0.13 ENSDART00000189198
BX547993.2

chr14_-_28052474 0.13 ENSDART00000172948
ENSDART00000135337
TSC22D3 (1 of many)
zgc:64189
si:ch211-220e11.3
zgc:64189
chr8_-_52594111 0.13 ENSDART00000167667
si:ch73-199g24.2
si:ch73-199g24.2
chr8_-_38201415 0.13 ENSDART00000155189
pdlim2
PDZ and LIM domain 2 (mystique)
chr1_-_57129179 0.13 ENSDART00000157226
ENSDART00000152469
si:ch73-94k4.2
si:ch73-94k4.2
chr23_-_2099350 0.13 ENSDART00000091532
ndnf
neuron-derived neurotrophic factor
chr18_-_33093705 0.12 ENSDART00000059500
olfcd3
olfactory receptor C family, d3
chr13_+_17694845 0.12 ENSDART00000079778
ifit8
interferon-induced protein with tetratricopeptide repeats 8
chr1_-_59104145 0.12 ENSDART00000132495
ENSDART00000152457
MFAP4 (1 of many)
si:zfos-2330d3.7
si:zfos-2330d3.1
si:zfos-2330d3.7
chr22_+_661505 0.12 ENSDART00000149460
elf3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr16_+_30961822 0.11 ENSDART00000059187
gstk2
glutathione S-transferase kappa 2
chr10_+_17088261 0.11 ENSDART00000132103
si:dkey-106l3.7
si:dkey-106l3.7
chr6_+_49926115 0.11 ENSDART00000018523
ahcy
adenosylhomocysteinase
chr19_+_38168006 0.11 ENSDART00000087662
ENSDART00000177759
phf14
PHD finger protein 14
chr15_-_37834433 0.09 ENSDART00000189748
si:dkey-238d18.3
si:dkey-238d18.3
chr4_+_33654247 0.09 ENSDART00000192537
si:dkey-84h14.1
si:dkey-84h14.1
chr4_+_35576329 0.09 ENSDART00000171191
ENSDART00000161611
si:dkeyp-4c4.2
si:dkeyp-4c4.2
chr22_+_14836040 0.09 ENSDART00000180951
gtpbp1l
GTP binding protein 1, like
chr2_+_42318012 0.09 ENSDART00000138137
ftr08
finTRIM family, member 8
chr10_-_40490647 0.09 ENSDART00000143660
taar20x
trace amine associated receptor 20x
chr7_-_1504382 0.09 ENSDART00000172770
si:zfos-405g10.4
si:zfos-405g10.4

Network of associatons between targets according to the STRING database.

First level regulatory network of smad3a+smad3b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0098543 detection of biotic stimulus(GO:0009595) detection of bacterium(GO:0016045) detection of other organism(GO:0098543) detection of external biotic stimulus(GO:0098581)
0.2 0.7 GO:0050427 sulfate assimilation(GO:0000103) purine ribonucleoside bisphosphate metabolic process(GO:0034035) purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428)
0.2 0.6 GO:0007571 age-dependent general metabolic decline(GO:0007571)
0.2 1.1 GO:0019262 N-acetylneuraminate catabolic process(GO:0019262)
0.1 0.6 GO:0032534 regulation of microvillus organization(GO:0032530) regulation of microvillus assembly(GO:0032534)
0.1 0.4 GO:0009193 ribonucleoside diphosphate catabolic process(GO:0009191) pyrimidine ribonucleoside diphosphate metabolic process(GO:0009193) UDP metabolic process(GO:0046048)
0.1 0.7 GO:0060584 regulation of systemic arterial blood pressure by endothelin(GO:0003100) vein smooth muscle contraction(GO:0014826) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.1 1.4 GO:0031573 intra-S DNA damage checkpoint(GO:0031573)
0.1 0.3 GO:0021577 hindbrain structural organization(GO:0021577) dorsal fin morphogenesis(GO:0035142) cell motility involved in somitogenic axis elongation(GO:0090247) cell migration involved in somitogenic axis elongation(GO:0090248)
0.1 0.5 GO:0018197 peptidyl-aspartic acid modification(GO:0018197) peptidyl-aspartic acid hydroxylation(GO:0042264)
0.1 0.9 GO:0060005 reflex(GO:0060004) vestibular reflex(GO:0060005) vestibular receptor cell differentiation(GO:0060114) vestibular receptor cell development(GO:0060118)
0.1 0.8 GO:0097106 postsynaptic density organization(GO:0097106)
0.1 0.6 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.1 0.7 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.1 0.4 GO:0030575 nuclear body organization(GO:0030575) Cajal body organization(GO:0030576) protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) protein localization to nucleoplasm(GO:1990173)
0.1 0.7 GO:0090385 phagosome-lysosome fusion(GO:0090385)
0.1 0.2 GO:0060785 regulation of apoptosis involved in tissue homeostasis(GO:0060785)
0.1 1.8 GO:0048936 peripheral nervous system neuron axonogenesis(GO:0048936)
0.1 0.2 GO:0007414 axonal defasciculation(GO:0007414)
0.1 0.2 GO:1904184 regulation of pyruvate dehydrogenase activity(GO:1904182) positive regulation of pyruvate dehydrogenase activity(GO:1904184)
0.1 0.3 GO:0019348 dolichol metabolic process(GO:0019348)
0.1 0.4 GO:0006012 galactose metabolic process(GO:0006012)
0.1 0.6 GO:0071459 protein localization to kinetochore(GO:0034501) protein localization to chromosome, centromeric region(GO:0071459)
0.1 0.2 GO:0090386 phagosome maturation involved in apoptotic cell clearance(GO:0090386) phagolysosome assembly involved in apoptotic cell clearance(GO:0090387)
0.1 0.6 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.1 1.5 GO:0019835 cytolysis(GO:0019835)
0.1 0.9 GO:1900107 regulation of nodal signaling pathway(GO:1900107)
0.0 0.5 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.0 0.4 GO:0032486 Rap protein signal transduction(GO:0032486)
0.0 0.3 GO:2000758 positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0 0.7 GO:0045580 regulation of T cell differentiation(GO:0045580)
0.0 0.1 GO:0021795 pallium development(GO:0021543) cerebral cortex cell migration(GO:0021795) cerebral cortex tangential migration(GO:0021800) cerebral cortex tangential migration using cell-axon interactions(GO:0021824) substrate-dependent cerebral cortex tangential migration(GO:0021825) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) cerebral cortex development(GO:0021987)
0.0 1.1 GO:0000460 maturation of 5.8S rRNA(GO:0000460)
0.0 0.4 GO:0033866 nucleoside bisphosphate biosynthetic process(GO:0033866) ribonucleoside bisphosphate biosynthetic process(GO:0034030) purine nucleoside bisphosphate biosynthetic process(GO:0034033)
0.0 0.8 GO:0048264 determination of ventral identity(GO:0048264)
0.0 0.6 GO:0007020 microtubule nucleation(GO:0007020)
0.0 0.1 GO:0015864 uridine transport(GO:0015862) pyrimidine nucleoside transport(GO:0015864)
0.0 0.6 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.0 0.3 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.0 1.0 GO:0046330 positive regulation of JNK cascade(GO:0046330)
0.0 0.5 GO:0043486 histone exchange(GO:0043486)
0.0 0.6 GO:0051014 actin filament severing(GO:0051014)
0.0 0.1 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.0 0.4 GO:0022011 myelination in peripheral nervous system(GO:0022011)
0.0 0.7 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.2 GO:0038061 NIK/NF-kappaB signaling(GO:0038061)
0.0 0.3 GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling(GO:0014068)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.2 0.6 GO:0000333 telomerase catalytic core complex(GO:0000333)
0.1 0.6 GO:0000931 gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.1 0.3 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.1 1.5 GO:0005579 membrane attack complex(GO:0005579)
0.1 0.5 GO:0000812 Swr1 complex(GO:0000812)
0.0 0.4 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.5 GO:0036038 MKS complex(GO:0036038)
0.0 0.7 GO:0000780 condensed nuclear chromosome kinetochore(GO:0000778) condensed nuclear chromosome, centromeric region(GO:0000780)
0.0 0.3 GO:0014704 intercalated disc(GO:0014704)
0.0 0.4 GO:0015030 Cajal body(GO:0015030)
0.0 6.8 GO:0005764 lysosome(GO:0005764)
0.0 0.5 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.6 GO:0005844 polysome(GO:0005844)
0.0 0.4 GO:0071141 SMAD protein complex(GO:0071141)
0.0 1.4 GO:0005814 centriole(GO:0005814)
0.0 0.4 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.0 0.6 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.2 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 0.2 GO:0005903 brush border(GO:0005903)
0.0 0.4 GO:0055038 recycling endosome membrane(GO:0055038)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0016019 peptidoglycan receptor activity(GO:0016019)
0.2 0.7 GO:0004020 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.2 0.6 GO:0003721 telomerase RNA reverse transcriptase activity(GO:0003721)
0.1 0.7 GO:0031708 endothelin B receptor binding(GO:0031708)
0.1 0.5 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.1 0.3 GO:0004377 GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity(GO:0004377)
0.1 0.4 GO:0032183 SUMO binding(GO:0032183)
0.1 0.8 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 0.4 GO:0004594 pantothenate kinase activity(GO:0004594)
0.1 0.3 GO:0008432 JUN kinase binding(GO:0008432)
0.1 0.5 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 0.2 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.1 0.7 GO:0004046 aminoacylase activity(GO:0004046)
0.1 1.1 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 7.2 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.5 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0 0.1 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.3 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 0.6 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.7 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.2 GO:0004630 phospholipase D activity(GO:0004630)
0.0 1.3 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.6 GO:0004698 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.0 0.5 GO:0034062 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.0 0.9 GO:0019209 kinase activator activity(GO:0019209) protein kinase activator activity(GO:0030295)
0.0 0.6 GO:0005109 frizzled binding(GO:0005109)
0.0 0.4 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 0.2 GO:0019894 kinesin binding(GO:0019894)
0.0 0.2 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.2 GO:0004382 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.0 0.6 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.1 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.0 GO:0001607 neuromedin U receptor activity(GO:0001607)
0.0 0.4 GO:0019003 GDP binding(GO:0019003)
0.0 0.4 GO:0019200 carbohydrate kinase activity(GO:0019200)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 0.9 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.7 PID AURORA B PATHWAY Aurora B signaling
0.0 0.2 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.7 PID ENDOTHELIN PATHWAY Endothelins
0.0 0.3 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 0.9 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.3 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.3 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.3 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.7 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.4 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.5 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.9 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.2 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.3 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.3 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.6 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.0 0.3 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.6 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.1 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway