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PRJEB1986: zebrafish developmental stages transcriptome

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Results for sox8a+sox8b

Z-value: 0.62

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Transcription factors associated with sox8a+sox8b

Gene Symbol Gene ID Gene Info
sox8b
ENSDARG00000037782 SRY-box transcription factor 8b
sox8a
ENSDARG00000105301 SRY-box transcription factor 8a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
sox8adr11_v1_chr12_-_1085227_1085227-0.691.1e-03Click!
sox8bdr11_v1_chr3_-_62403550_62403550-0.204.0e-01Click!

Activity profile of sox8a+sox8b motif

Sorted Z-values of sox8a+sox8b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_11949996 1.94 ENSDART00000163478
ENSDART00000167299
cpsf1
cleavage and polyadenylation specific factor 1
chr19_-_11950434 1.90 ENSDART00000024861
cpsf1
cleavage and polyadenylation specific factor 1
chr23_-_27235403 1.82 ENSDART00000134418
si:dkey-157g16.6
si:dkey-157g16.6
chr19_+_27448625 1.44 ENSDART00000052352
ppp1r11
protein phosphatase 1, regulatory (inhibitor) subunit 11
chr9_+_34952203 1.44 ENSDART00000121828
ENSDART00000142347
tfdp1a
transcription factor Dp-1, a
chr3_-_27647845 1.35 ENSDART00000151625
si:ch211-157c3.4
si:ch211-157c3.4
chr11_-_30138299 1.33 ENSDART00000172106
scml2
Scm polycomb group protein like 2
chr17_+_24687338 1.26 ENSDART00000135794
selenon
selenoprotein N
chr19_-_17208728 1.17 ENSDART00000151228
stmn1a
stathmin 1a
chr14_+_38786298 1.13 ENSDART00000164440
si:ch211-195b11.3
si:ch211-195b11.3
chr9_-_8979468 1.10 ENSDART00000134646
ing1
inhibitor of growth family, member 1
chr21_+_34088110 1.08 ENSDART00000145123
ENSDART00000029599
ENSDART00000147519
mtmr1b
myotubularin related protein 1b
chr12_+_30705769 1.07 ENSDART00000186448
ENSDART00000066259
kcnk1a
potassium channel, subfamily K, member 1a
chr24_-_21923930 1.05 ENSDART00000131944
tagln3b
transgelin 3b
chr22_+_9522971 1.05 ENSDART00000110048
strip1
striatin interacting protein 1
chr11_-_18015534 1.02 ENSDART00000181953
qrich1
glutamine-rich 1
chr4_+_22297839 0.99 ENSDART00000077707
llph
LLP homolog, long-term synaptic facilitation (Aplysia)
chr2_+_24770435 0.95 ENSDART00000078854
mpv17l2
MPV17 mitochondrial membrane protein-like 2
chr5_+_45008418 0.92 ENSDART00000189882
dmrt2a
doublesex and mab-3 related transcription factor 2a
chr8_+_41238064 0.89 ENSDART00000111321
zgc:152830
zgc:152830
chr2_-_24554416 0.89 ENSDART00000052061
cnn2
calponin 2
chr13_-_44423 0.86 ENSDART00000093247
gtf2a1l
general transcription factor IIA, 1-like
chr2_+_15048410 0.84 ENSDART00000058484
cnn3b
calponin 3, acidic b
chr7_+_25003851 0.83 ENSDART00000144526
naa40
N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae)
chr1_+_38362412 0.82 ENSDART00000075086
cep44
centrosomal protein 44
chr9_-_23147026 0.78 ENSDART00000167266
lypd6b
LY6/PLAUR domain containing 6B
chr9_-_8979154 0.77 ENSDART00000145266
ing1
inhibitor of growth family, member 1
chr21_+_42717424 0.74 ENSDART00000166936
ENSDART00000172135
sh3pxd2b
SH3 and PX domains 2B
chr1_-_26063188 0.72 ENSDART00000168640
pdcd4a
programmed cell death 4a
chr10_-_14545658 0.72 ENSDART00000057865
ier3ip1
immediate early response 3 interacting protein 1
chr3_+_62327332 0.71 ENSDART00000158414
BX470259.1

chr20_-_39391833 0.71 ENSDART00000135149
si:dkey-217m5.8
si:dkey-217m5.8
chr22_-_14262115 0.70 ENSDART00000168264
si:ch211-246m6.5
si:ch211-246m6.5
chr12_+_30706158 0.69 ENSDART00000133869
kcnk1a
potassium channel, subfamily K, member 1a
chr21_+_43328685 0.66 ENSDART00000109620
ENSDART00000139668
sept8a
septin 8a
chr2_-_22492289 0.65 ENSDART00000168022
gtf2b
general transcription factor IIB
chr7_+_52753067 0.65 ENSDART00000053814
mtfmt
mitochondrial methionyl-tRNA formyltransferase
chr21_+_34088377 0.64 ENSDART00000170070
mtmr1b
myotubularin related protein 1b
chr14_+_48862987 0.63 ENSDART00000167810
zgc:154054
zgc:154054
chr21_+_39673157 0.61 ENSDART00000100240
mrm3b
mitochondrial rRNA methyltransferase 3b
chr19_-_27448606 0.61 ENSDART00000079251
vars2
valyl-tRNA synthetase 2, mitochondrial (putative)
chr6_-_48347724 0.60 ENSDART00000046973
capza1a
capping protein (actin filament) muscle Z-line, alpha 1a
chr23_-_36418708 0.59 ENSDART00000132273
znf740b
zinc finger protein 740b
chr17_+_24604373 0.57 ENSDART00000082193
zmpste24
zinc metallopeptidase, STE24 homolog
chr10_+_11398111 0.56 ENSDART00000064210
cwc27
CWC27 spliceosome-associated protein homolog (S. cerevisiae)
chr12_+_34258139 0.55 ENSDART00000153127
socs3b
suppressor of cytokine signaling 3b
chr19_+_11432330 0.54 ENSDART00000188065
PQLC1
PQ loop repeat containing 1
chr20_-_39391492 0.54 ENSDART00000184886
si:dkey-217m5.8
si:dkey-217m5.8
chr10_+_7709724 0.52 ENSDART00000097670
ggcx
gamma-glutamyl carboxylase
chr13_+_8892784 0.51 ENSDART00000075054
ENSDART00000143705
thada
thyroid adenoma associated
chr1_-_16688965 0.50 ENSDART00000079001
ENSDART00000178599
frg1
FSHD region gene 1
chr17_-_33707589 0.49 ENSDART00000124788
si:dkey-84k17.2
si:dkey-84k17.2
chr7_-_18547420 0.49 ENSDART00000173969
rgs12a
regulator of G protein signaling 12a
chr17_+_14784275 0.49 ENSDART00000005355
rtraf
RNA transcription, translation and transport factor
chr15_-_43327911 0.48 ENSDART00000077386
prss16
protease, serine, 16 (thymus)
chr14_+_11457500 0.45 ENSDART00000169202
si:ch211-153b23.5
si:ch211-153b23.5
chr3_+_39579393 0.45 ENSDART00000055170
cln3
ceroid-lipofuscinosis, neuronal 3
chr6_+_13506841 0.44 ENSDART00000032331
gmppab
GDP-mannose pyrophosphorylase Ab
chr19_+_3653976 0.43 ENSDART00000125673
nedd9
neural precursor cell expressed, developmentally down-regulated 9
chr7_+_65121743 0.37 ENSDART00000108471
ipo7
importin 7
chr25_-_37248795 0.37 ENSDART00000087247
ENSDART00000154045
glg1a
golgi glycoprotein 1a
chr21_-_43328056 0.36 ENSDART00000114955
sowahaa
sosondowah ankyrin repeat domain family member Aa
chr10_+_5268054 0.36 ENSDART00000114491
ror2
receptor tyrosine kinase-like orphan receptor 2
chr16_-_25607266 0.35 ENSDART00000192602
zgc:110410
zgc:110410
chr5_+_41146786 0.34 ENSDART00000175766
sub1b
SUB1 homolog, transcriptional regulator b
chr20_+_30578967 0.33 ENSDART00000010494
fgfr1op
FGFR1 oncogene partner
chr23_+_4890693 0.32 ENSDART00000023537
tnnc1a
troponin C type 1a (slow)
chr16_-_25606889 0.32 ENSDART00000077447
ENSDART00000131528
zgc:110410
zgc:110410
chr16_-_21047872 0.31 ENSDART00000131582
cbx3b
chromobox homolog 3b
chr8_-_7603516 0.31 ENSDART00000179826
ENSDART00000190153
irak1
interleukin-1 receptor-associated kinase 1
chr16_+_46410520 0.31 ENSDART00000131072
rpz2
rapunzel 2
chr6_-_37743724 0.31 ENSDART00000149068
nipa2
non imprinted in Prader-Willi/Angelman syndrome 2 (human)
chr3_+_32663865 0.31 ENSDART00000190240
si:dkey-16l2.16
si:dkey-16l2.16
chr7_-_50410524 0.30 ENSDART00000083346
hypk
huntingtin interacting protein K
chr22_-_817479 0.30 ENSDART00000123487
zgc:153675
zgc:153675
chr8_-_7603700 0.30 ENSDART00000137975
irak1
interleukin-1 receptor-associated kinase 1
chr8_-_46386024 0.29 ENSDART00000136602
ENSDART00000060919
ENSDART00000137472
qars
glutaminyl-tRNA synthetase
chr10_+_40629616 0.29 ENSDART00000147476
CR396590.9

chr15_+_28368823 0.29 ENSDART00000142298
slc43a2a
solute carrier family 43 (amino acid system L transporter), member 2a
chr12_+_18544159 0.28 ENSDART00000162900
mlst8
MTOR associated protein, LST8 homolog (S. cerevisiae)
chr8_+_42718135 0.27 ENSDART00000158900
zgc:194007
zgc:194007
chr14_-_25452503 0.26 ENSDART00000148652
slc26a2
solute carrier family 26 (anion exchanger), member 2
chr11_+_13176568 0.26 ENSDART00000125371
ENSDART00000123257
mknk1
MAP kinase interacting serine/threonine kinase 1
chr13_+_30225262 0.24 ENSDART00000141945
rps24
ribosomal protein S24
chr9_-_3934963 0.23 ENSDART00000062336
ubr3
ubiquitin protein ligase E3 component n-recognin 3
chr20_-_3276339 0.23 ENSDART00000166831
rps6kc1
ribosomal protein S6 kinase polypeptide 1
chr11_-_45138857 0.22 ENSDART00000166501
cant1b
calcium activated nucleotidase 1b
chr1_+_6646529 0.22 ENSDART00000144641
ENSDART00000103701
ENSDART00000138919
ube2f
ubiquitin-conjugating enzyme E2F (putative)
chr14_+_6546516 0.21 ENSDART00000097214
adam19b
ADAM metallopeptidase domain 19b
chr19_-_24163845 0.21 ENSDART00000133277
prf1.2
perforin 1.2
chr6_+_49926115 0.20 ENSDART00000018523
ahcy
adenosylhomocysteinase
chr3_-_3413669 0.17 ENSDART00000113517
ENSDART00000179861
ENSDART00000115331
zgc:171446
zgc:171446
chr19_-_24198139 0.16 ENSDART00000138864
ENSDART00000125350
prf1.7
perforin 1.7
chr19_-_19664743 0.13 ENSDART00000187419
BX601646.1

chr18_+_45666489 0.13 ENSDART00000180147
ENSDART00000151351
prrg4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr10_+_9595575 0.08 ENSDART00000091780
ENSDART00000184287
rc3h2
ring finger and CCCH-type domains 2
chr5_+_31214341 0.07 ENSDART00000133432
atp2a3
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
chr16_+_25095483 0.07 ENSDART00000155032
si:ch211-261d7.3
si:ch211-261d7.3
chr18_+_5917625 0.06 ENSDART00000169100
glg1b
golgi glycoprotein 1b
chr9_+_23714406 0.04 ENSDART00000189445
gypc
glycophorin C (Gerbich blood group)
chr4_+_39766931 0.03 ENSDART00000138663
si:dkeyp-85d8.1
si:dkeyp-85d8.1
chr23_-_35694171 0.02 ENSDART00000077539
tuba1c
tubulin, alpha 1c
chr9_+_50001746 0.02 ENSDART00000058892
slc38a11
solute carrier family 38, member 11
chr3_+_3573696 0.01 ENSDART00000169680
CR589947.2

chr16_+_40508882 0.01 ENSDART00000126129
nagpa
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
chr4_+_6833583 0.01 ENSDART00000165179
ENSDART00000186134
ENSDART00000174507
dock4b
dedicator of cytokinesis 4b
chr22_+_24673168 0.00 ENSDART00000135257
si:rp71-23d18.8
si:rp71-23d18.8
chr15_+_28368644 0.00 ENSDART00000168453
slc43a2a
solute carrier family 43 (amino acid system L transporter), member 2a

Network of associatons between targets according to the STRING database.

First level regulatory network of sox8a+sox8b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0061668 mitochondrial ribosome assembly(GO:0061668)
0.2 0.6 GO:0080120 CAAX-box protein processing(GO:0071586) CAAX-box protein maturation(GO:0080120)
0.2 1.4 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.2 1.3 GO:0050848 regulation of calcium-mediated signaling(GO:0050848)
0.1 3.8 GO:0043631 mRNA polyadenylation(GO:0006378) RNA polyadenylation(GO:0043631)
0.1 0.7 GO:0071800 podosome assembly(GO:0071800)
0.1 0.5 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.1 0.4 GO:0090527 actin filament reorganization(GO:0090527)
0.1 0.3 GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.1 0.4 GO:0009298 GDP-mannose biosynthetic process(GO:0009298)
0.1 1.8 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 0.6 GO:0070498 interleukin-1-mediated signaling pathway(GO:0070498)
0.1 0.5 GO:0015809 arginine transport(GO:0015809)
0.1 1.0 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.1 0.8 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.1 0.7 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 0.2 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0 0.2 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.0 0.9 GO:0043535 regulation of blood vessel endothelial cell migration(GO:0043535)
0.0 1.7 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.9 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 0.2 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0 0.6 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.0 0.9 GO:0007548 sex differentiation(GO:0007548)
0.0 0.5 GO:1990798 pancreas regeneration(GO:1990798)
0.0 0.3 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.6 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.3 GO:0014823 response to activity(GO:0014823)
0.0 1.0 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 1.9 GO:0008285 negative regulation of cell proliferation(GO:0008285)
0.0 0.2 GO:0045116 protein neddylation(GO:0045116)
0.0 0.4 GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling(GO:0014068)
0.0 0.6 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.0 0.4 GO:0019835 cytolysis(GO:0019835)
0.0 1.3 GO:0010466 negative regulation of peptidase activity(GO:0010466)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.8 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.2 0.9 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.1 0.6 GO:0008290 F-actin capping protein complex(GO:0008290)
0.1 0.7 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 0.5 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.1 0.6 GO:0071005 U2-type precatalytic spliceosome(GO:0071005)
0.1 0.7 GO:0002102 podosome(GO:0002102)
0.0 1.8 GO:0043204 perikaryon(GO:0043204)
0.0 0.3 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.5 GO:0015030 Cajal body(GO:0015030)
0.0 0.4 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.8 GO:0030496 midbody(GO:0030496)
0.0 0.6 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 0.7 GO:0031105 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 1.8 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 0.7 GO:0030134 ER to Golgi transport vesicle(GO:0030134)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0043998 H2A histone acetyltransferase activity(GO:0043998)
0.2 1.7 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.2 1.4 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1 0.5 GO:0008488 gamma-glutamyl carboxylase activity(GO:0008488)
0.1 0.8 GO:0030548 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.1 1.8 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.1 0.4 GO:0004475 mannose-1-phosphate guanylyltransferase activity(GO:0004475) mannose-phosphate guanylyltransferase activity(GO:0008905)
0.1 0.7 GO:0001047 core promoter sequence-specific DNA binding(GO:0001046) core promoter binding(GO:0001047)
0.1 0.7 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175) superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1 0.6 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.1 0.2 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 0.6 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.1 1.9 GO:0035064 methylated histone binding(GO:0035064)
0.0 1.5 GO:0001098 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0 0.5 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.9 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.4 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 0.5 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.3 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.3 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.1 GO:0035613 RNA stem-loop binding(GO:0035613)
0.0 0.3 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 1.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.6 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 0.4 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 2.0 GO:0005516 calmodulin binding(GO:0005516)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.4 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.3 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.8 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.1 0.6 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.1 0.5 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.9 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.3 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.3 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.7 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.3 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants