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PRJEB1986: zebrafish developmental stages transcriptome

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Results for srebf2

Z-value: 0.30

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Transcription factors associated with srebf2

Gene Symbol Gene ID Gene Info
srebf2
ENSDARG00000063438 sterol regulatory element binding transcription factor 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
srebf2dr11_v1_chr3_+_1107102_11071020.598.5e-03Click!

Activity profile of srebf2 motif

Sorted Z-values of srebf2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr13_-_992458 1.07 ENSDART00000114655
BFSP1
beaded filament structural protein 1
chr7_+_22616212 0.67 ENSDART00000052844
cldn7a
claudin 7a
chr19_-_10196370 0.65 ENSDART00000091707
dbpa
D site albumin promoter binding protein a
chr2_+_24203229 0.49 ENSDART00000138088
map4l
microtubule associated protein 4 like
chr10_-_5053589 0.49 ENSDART00000193579
tmem150c
transmembrane protein 150C
chr9_+_54417141 0.47 ENSDART00000056810
drd1b
dopamine receptor D1b
chr21_-_19006631 0.46 ENSDART00000080269
ENSDART00000191682
pgam2
phosphoglycerate mutase 2 (muscle)
chr22_+_17286841 0.44 ENSDART00000133176
FAM163A
si:dkey-171o17.8
chr10_-_31782616 0.42 ENSDART00000128839
fez1
fasciculation and elongation protein zeta 1 (zygin I)
chr15_+_30157602 0.42 ENSDART00000047248
ENSDART00000123937
nlk2
nemo-like kinase, type 2
chr4_+_19535946 0.41 ENSDART00000192342
ENSDART00000183740
ENSDART00000180812
ENSDART00000180017
lrrc4.1
leucine rich repeat containing 4.1
chr3_+_19299309 0.41 ENSDART00000046297
ENSDART00000146955
ldlra
low density lipoprotein receptor a
chr6_-_15101477 0.37 ENSDART00000187713
ENSDART00000124132
fhl2b
four and a half LIM domains 2b
chr16_+_41874001 0.37 ENSDART00000161278
scn1ba
sodium channel, voltage-gated, type I, beta a
chr16_+_41873708 0.34 ENSDART00000084631
ENSDART00000084639
ENSDART00000058611
scn1ba
sodium channel, voltage-gated, type I, beta a
chr7_-_30082931 0.32 ENSDART00000075600
tspan3b
tetraspanin 3b
chr22_-_13466246 0.31 ENSDART00000134035
cntnap5b
contactin associated protein-like 5b
chr10_-_35220285 0.30 ENSDART00000180439
ypel2a
yippee-like 2a
chr11_+_14280598 0.30 ENSDART00000163033
si:ch211-262i1.3
si:ch211-262i1.3
chr21_+_28445052 0.30 ENSDART00000077871
pygma
phosphorylase, glycogen, muscle A
chr13_+_33703784 0.30 ENSDART00000173361
macrod2
MACRO domain containing 2
chr21_-_43550120 0.30 ENSDART00000151627
si:ch73-362m14.2
si:ch73-362m14.2
chr12_+_33395748 0.29 ENSDART00000129458
fasn
fatty acid synthase
chr7_-_71486162 0.28 ENSDART00000045253
aco1
aconitase 1, soluble
chr17_-_48915427 0.28 ENSDART00000054781
lgals8b
galectin 8b
chr9_-_4075620 0.28 ENSDART00000046903
mylka
myosin, light chain kinase a
chr18_+_14342326 0.27 ENSDART00000181013
ENSDART00000138372
si:dkey-246g23.2
si:dkey-246g23.2
chr14_-_33894915 0.27 ENSDART00000143290
urp1
urotensin-related peptide 1
chr20_-_7176809 0.27 ENSDART00000012247
ENSDART00000125019
dhcr24
24-dehydrocholesterol reductase
chr1_-_9940494 0.26 ENSDART00000138726
tmem8a
transmembrane protein 8A
chr20_-_27311675 0.26 ENSDART00000026088
ENSDART00000148361
asb2a.1
ankyrin repeat and SOCS box containing 2a, tandem duplicate 1
chr18_-_21271373 0.25 ENSDART00000060001
pnp6
purine nucleoside phosphorylase 6
chr12_-_23009312 0.23 ENSDART00000111801
mkxa
mohawk homeobox a
chr3_-_61099004 0.23 ENSDART00000112043
cacng4b
calcium channel, voltage-dependent, gamma subunit 4b
chr8_+_22916536 0.22 ENSDART00000136403
cacna1fb
calcium channel, voltage-dependent, L type, alpha 1F subunit
chr18_-_39188664 0.22 ENSDART00000162983
mapk6
mitogen-activated protein kinase 6
chr5_-_12524996 0.20 ENSDART00000142258
si:ch73-263f13.1
si:ch73-263f13.1
chr23_-_27694960 0.20 ENSDART00000135129
IKZF4
si:dkey-166n8.9
chr3_+_47245764 0.19 ENSDART00000193581
tnfsf14
TNF superfamily member 14
chr6_+_10094061 0.19 ENSDART00000150998
ENSDART00000162236
atp7b
ATPase copper transporting beta
chr5_-_69948099 0.18 ENSDART00000034639
ENSDART00000191111
ugt2a4
UDP glucuronosyltransferase 2 family, polypeptide A4
chr22_-_13165186 0.18 ENSDART00000105762
ahr2
aryl hydrocarbon receptor 2
chr12_+_2660733 0.18 ENSDART00000152235
irbpl
interphotoreceptor retinoid-binding protein like
chr5_+_45976130 0.17 ENSDART00000175670
sv2c
synaptic vesicle glycoprotein 2C
chr1_+_9557212 0.16 ENSDART00000111131
elfn1b
extracellular leucine-rich repeat and fibronectin type III domain containing 1b
chr2_+_10127762 0.16 ENSDART00000100726
insl5b
insulin-like 5b
chr24_-_28229618 0.16 ENSDART00000145290
bcl2a
BCL2, apoptosis regulator a
chr3_-_34296361 0.16 ENSDART00000181485
ENSDART00000113726
tnrc6c1
trinucleotide repeat containing 6C1
chr11_+_14281100 0.15 ENSDART00000193664
ENSDART00000161597
si:ch211-262i1.3
si:ch211-262i1.3
chr6_-_15639087 0.15 ENSDART00000128940
ENSDART00000183092
mlpha
melanophilin a
chr6_+_102506 0.14 ENSDART00000172678
ldlrb
low density lipoprotein receptor b
chr3_-_45308394 0.13 ENSDART00000155324
pdpk1a
3-phosphoinositide dependent protein kinase 1a
chr1_+_41690402 0.13 ENSDART00000177298
fbxo41
F-box protein 41
chr6_-_19351495 0.13 ENSDART00000164287
grb2a
growth factor receptor-bound protein 2a
chr24_+_40860320 0.12 ENSDART00000161351
gorasp1b
golgi reassembly stacking protein 1b
chr14_-_46117345 0.12 ENSDART00000172166
NDUFC1
si:ch211-235e9.6
chr3_+_12755535 0.11 ENSDART00000161286
cyp2k17
cytochrome P450, family 2, subfamily K, polypeptide17
chr17_-_7436766 0.10 ENSDART00000162002
grm1b
glutamate receptor, metabotropic 1b
chr21_-_1742159 0.10 ENSDART00000151049
onecut2
one cut homeobox 2
chr9_-_30363770 0.10 ENSDART00000147030
sytl5
synaptotagmin-like 5
chr12_-_34459601 0.10 ENSDART00000111717
fscn2b
fascin actin-bundling protein 2b, retinal
chr22_+_344763 0.10 ENSDART00000181934
CU914780.1

chr1_-_30689004 0.08 ENSDART00000018827
dachc
dachshund c
chr18_+_39649825 0.07 ENSDART00000087960
gldn
gliomedin
chr24_+_9590188 0.06 ENSDART00000137092
si:dkey-96n2.1
si:dkey-96n2.1
chr1_-_20826023 0.06 ENSDART00000054472
tll1
tolloid-like 1
chr5_+_37032038 0.05 ENSDART00000045036
nfkbib
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr1_+_12178215 0.05 ENSDART00000090380
stra6l
STRA6-like
chr23_-_20258490 0.05 ENSDART00000147326
lamb2
laminin, beta 2 (laminin S)
chr18_-_27628784 0.05 ENSDART00000180885
BX005470.1

chr4_+_41311345 0.05 ENSDART00000151905
si:dkey-16p19.8
si:dkey-16p19.8
chr22_-_6959769 0.05 ENSDART00000105866
si:ch73-213k20.5
si:ch73-213k20.5
chr3_+_1107102 0.04 ENSDART00000092690
srebf2
sterol regulatory element binding transcription factor 2
chr11_-_3334248 0.04 ENSDART00000154314
ENSDART00000121861
prph
peripherin
chr5_-_15321451 0.04 ENSDART00000139203
txnrd2.1
thioredoxin reductase 2, tandem duplicate 1
chr8_-_26961779 0.03 ENSDART00000099214
slc16a1b
solute carrier family 16 (monocarboxylate transporter), member 1b
chr16_+_30316177 0.03 ENSDART00000109505
tmem79b
transmembrane protein 79b
chr7_-_30932094 0.03 ENSDART00000057677
terb2
telomere repeat binding bouquet formation protein 2
chr9_-_38579758 0.03 ENSDART00000131738
si:dkey-101k6.5
si:dkey-101k6.5
chr24_-_37326236 0.03 ENSDART00000003789
pdpk1b
3-phosphoinositide dependent protein kinase 1b
chr13_+_4409294 0.02 ENSDART00000146437
si:ch211-130h14.4
si:ch211-130h14.4
chr15_+_22333778 0.01 ENSDART00000114937
pde9al
phosphodiesterase 9A like
chr22_-_8931093 0.01 ENSDART00000181813
FO393424.3

chr3_+_14558188 0.01 ENSDART00000143904
epor
erythropoietin receptor
chr18_+_8231138 0.01 ENSDART00000140193
arsa
arylsulfatase A
chr24_-_40860603 0.00 ENSDART00000188032
CU633479.7

Network of associatons between targets according to the STRING database.

First level regulatory network of srebf2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0086091 regulation of heart rate by cardiac conduction(GO:0086091)
0.1 0.3 GO:0052576 carbohydrate localization(GO:0052575) carbohydrate storage(GO:0052576)
0.1 0.3 GO:0010039 response to iron ion(GO:0010039)
0.1 0.4 GO:0032367 intracellular cholesterol transport(GO:0032367)
0.1 0.5 GO:0042311 vasodilation(GO:0042311)
0.0 0.2 GO:0043029 T cell homeostasis(GO:0043029)
0.0 0.2 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.0 0.1 GO:0051876 pigment granule dispersal(GO:0051876)
0.0 0.2 GO:0045445 myoblast differentiation(GO:0045445)
0.0 0.5 GO:0007520 myoblast fusion(GO:0007520)
0.0 0.2 GO:0042698 ovarian follicle development(GO:0001541) ovulation cycle process(GO:0022602) ovulation cycle(GO:0042698)
0.0 0.1 GO:0035124 embryonic caudal fin morphogenesis(GO:0035124)
0.0 0.7 GO:0043297 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.0 0.2 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.0 0.2 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.0 0.1 GO:0071938 vitamin A transport(GO:0071938) vitamin A import(GO:0071939)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 GO:0001518 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.2 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.1 0.4 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
0.1 0.3 GO:0003994 aconitate hydratase activity(GO:0003994)
0.1 0.5 GO:0004082 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619)
0.1 0.7 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.1 0.3 GO:0004645 phosphorylase activity(GO:0004645) glycogen phosphorylase activity(GO:0008184)
0.0 0.2 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.0 0.2 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.0 0.3 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.6 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.1 GO:0099530 G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.0 0.3 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.5 REACTOME GLYCOLYSIS Genes involved in Glycolysis