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PRJEB1986: zebrafish developmental stages transcriptome

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Results for stat1a+stat2-1_stat1b

Z-value: 1.70

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Transcription factors associated with stat1a+stat2-1_stat1b

Gene Symbol Gene ID Gene Info
stat1a
ENSDARG00000006266 signal transducer and activator of transcription 1a
stat2-1
ENSDARG00000031647 signal transducer and activator of transcription 2
stat1b
ENSDARG00000076182 signal transducer and activator of transcription 1b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
stat1adr11_v1_chr22_+_12798569_127985690.953.4e-10Click!
stat2dr11_v1_chr6_-_39158953_391589530.662.0e-03Click!
stat1bdr11_v1_chr9_+_41218967_412189740.598.2e-03Click!

Activity profile of stat1a+stat2-1_stat1b motif

Sorted Z-values of stat1a+stat2-1_stat1b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_61205711 12.69 ENSDART00000055062
pvalb1
parvalbumin 1
chr12_-_3252263 8.28 ENSDART00000170632
gngt2b
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2b
chr16_-_36834505 8.00 ENSDART00000141275
ENSDART00000139588
ENSDART00000041993
pnp4b
purine nucleoside phosphorylase 4b
chr5_-_30620625 7.60 ENSDART00000098273
tcnl
transcobalamin like
chr7_+_73295890 7.44 ENSDART00000174331
ENSDART00000174250
CABZ01083442.1

chr20_+_10166297 6.98 ENSDART00000141877
kcnk10a
potassium channel, subfamily K, member 10a
chr6_+_41503854 6.74 ENSDART00000136538
ENSDART00000140108
ENSDART00000084861
cish
cytokine inducible SH2-containing protein
chr17_-_6730247 6.59 ENSDART00000031091
vsnl1b
visinin-like 1b
chr21_+_39100289 6.19 ENSDART00000075958
slc13a2
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
chr13_+_52061034 5.92 ENSDART00000170383
CABZ01089777.1

chr10_-_11385155 5.60 ENSDART00000064214
plac8.1
placenta-specific 8, tandem duplicate 1
chr18_+_49411417 5.47 ENSDART00000028944
LRFN3
zmp:0000001073
chr16_-_52879741 5.27 ENSDART00000166470
TPPP
tubulin polymerization promoting protein
chr24_+_5208171 5.17 ENSDART00000155926
ENSDART00000154464
si:ch73-206p6.1
si:ch73-206p6.1
chr9_-_23922011 5.16 ENSDART00000145734
col6a3
collagen, type VI, alpha 3
chr9_-_6372535 5.07 ENSDART00000149189
ecrg4a
esophageal cancer related gene 4a
chr9_-_9282519 4.70 ENSDART00000146821
si:ch211-214p13.3
si:ch211-214p13.3
chr23_+_44611864 4.67 ENSDART00000145905
ENSDART00000132361
eno3
enolase 3, (beta, muscle)
chr21_+_45626136 4.48 ENSDART00000158742
irf1b
interferon regulatory factor 1b
chr18_+_7264961 4.43 ENSDART00000188461
CABZ01015105.1

chr24_+_42948 4.27 ENSDART00000122785
tmx3b
thioredoxin related transmembrane protein 3b
chr2_-_38125657 4.12 ENSDART00000143433
cbln12
cerebellin 12
chr3_+_25154078 4.08 ENSDART00000156973
si:ch211-256m1.8
si:ch211-256m1.8
chr14_+_6159162 4.01 ENSDART00000128638
bscl2l
Bernardinelli-Seip congenital lipodystrophy 2, like
chr22_+_7480465 3.94 ENSDART00000034545
CELA1 (1 of many)
zgc:92745
chr18_-_16801033 3.91 ENSDART00000100100
admb
adrenomedullin b
chr2_-_42091926 3.78 ENSDART00000142663
si:dkey-97a13.12
si:dkey-97a13.12
chr19_+_48176745 3.70 ENSDART00000164963
prdm1b
PR domain containing 1b, with ZNF domain
chr1_+_44053641 3.69 ENSDART00000124873
si:ch73-109d9.4
si:ch73-109d9.4
chr20_+_13969414 3.65 ENSDART00000049864
rd3
retinal degeneration 3
chr5_+_23118470 3.39 ENSDART00000149893
nexmifa
neurite extension and migration factor a
chr4_-_5291256 3.35 ENSDART00000150864
SNAP91 (1 of many)
si:ch211-214j24.9
chr13_+_1535511 3.34 ENSDART00000159454
CABZ01044277.1

chr24_+_24923166 3.25 ENSDART00000065288
pcyt1ba
phosphate cytidylyltransferase 1, choline, beta a
chr13_-_37631092 3.23 ENSDART00000108855
si:dkey-188i13.7
si:dkey-188i13.7
chr12_-_4683325 3.22 ENSDART00000152771
si:ch211-255p10.3
si:ch211-255p10.3
chr11_-_762721 3.03 ENSDART00000166465
syn2b
synapsin IIb
chr7_-_71837213 3.02 ENSDART00000168645
ENSDART00000160512
cacnb2a
calcium channel, voltage-dependent, beta 2a
chr23_+_20408227 3.01 ENSDART00000134727
si:rp71-17i16.4
si:rp71-17i16.4
chr4_-_18436899 2.99 ENSDART00000141671
socs2
suppressor of cytokine signaling 2
chr15_+_16521785 2.96 ENSDART00000062191
galnt17
polypeptide N-acetylgalactosaminyltransferase 17
chr7_+_30787903 2.92 ENSDART00000174000
apba2b
amyloid beta (A4) precursor protein-binding, family A, member 2b
chr25_-_8160030 2.88 ENSDART00000067159
tph1a
tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) a
chr22_+_5851122 2.77 ENSDART00000082044
zmp:0000001161
zmp:0000001161
chr9_-_23922778 2.72 ENSDART00000135769
col6a3
collagen, type VI, alpha 3
chr23_+_45229198 2.69 ENSDART00000172445
ttc39b
tetratricopeptide repeat domain 39B
chr17_-_45040813 2.66 ENSDART00000075514
entpd5a
ectonucleoside triphosphate diphosphohydrolase 5a
chr18_+_10820430 2.60 ENSDART00000161990
mical3a
microtubule associated monooxygenase, calponin and LIM domain containing 3a
chr15_-_29598444 2.59 ENSDART00000154847
si:ch211-207n23.2
si:ch211-207n23.2
chr18_+_17660402 2.59 ENSDART00000143475
cpne2
copine II
chr15_-_29598679 2.58 ENSDART00000155153
si:ch211-207n23.2
si:ch211-207n23.2
chr11_+_43401592 2.58 ENSDART00000112468
vipb
vasoactive intestinal peptide b
chr2_+_38556195 2.56 ENSDART00000138769
cdh24b
cadherin 24, type 2b
chr3_-_44059902 2.53 ENSDART00000158485
ENSDART00000159088
ENSDART00000165628
il4r.1
interleukin 4 receptor, tandem duplicate 1
chr3_+_26813058 2.52 ENSDART00000055537
socs1a
suppressor of cytokine signaling 1a
chr9_-_32813177 2.51 ENSDART00000012694
mxc
myxovirus (influenza virus) resistance C
chr16_-_17188294 2.44 ENSDART00000165883
opn9
opsin 9
chr20_-_25551676 2.40 ENSDART00000063081
cyp2ad3
cytochrome P450, family 2, subfamily AD, polypeptide 3
chr14_-_2206476 2.39 ENSDART00000081870
pcdh2ab6
protocadherin 2 alpha b 6
chr12_-_3133483 2.38 ENSDART00000015092
col1a1b
collagen, type I, alpha 1b
chr8_-_42677086 2.32 ENSDART00000191173
si:ch73-138n13.1
si:ch73-138n13.1
chr10_-_4375190 2.31 ENSDART00000016102
CABZ01073795.1

chr16_-_36099492 2.29 ENSDART00000180905
CU499336.2

chr12_+_22607761 2.25 ENSDART00000153112
si:dkey-219e21.2
si:dkey-219e21.2
chr23_-_39636195 2.21 ENSDART00000144439
vwa1
von Willebrand factor A domain containing 1
chr1_-_53407087 2.21 ENSDART00000157910
elmod2
ELMO/CED-12 domain containing 2
chr9_+_51265283 2.20 ENSDART00000137426
gcgb
glucagon b
chr8_-_5155545 2.13 ENSDART00000056885
DPYSL2 (1 of many)
dihydropyrimidinase like 2
chr2_+_7295515 2.10 ENSDART00000152987
si:dkeyp-106c3.1
si:dkeyp-106c3.1
chr16_-_22251414 2.08 ENSDART00000158500
ENSDART00000179998
atp8b2
ATPase phospholipid transporting 8B2
chr15_-_2903475 2.07 ENSDART00000043226
guca1c
guanylate cyclase activator 1C
chr8_-_14052349 2.06 ENSDART00000135811
atp2b3a
ATPase plasma membrane Ca2+ transporting 3a
chr24_-_5932982 2.05 ENSDART00000138412
ENSDART00000135124
ENSDART00000007373
acbd5a
acyl-CoA binding domain containing 5a
chr16_+_45746549 2.01 ENSDART00000190403
paqr6
progestin and adipoQ receptor family member VI
chr11_-_17964525 1.99 ENSDART00000018948
cishb
cytokine inducible SH2-containing protein b
chr7_-_52842605 1.98 ENSDART00000083002
map1aa
microtubule-associated protein 1Aa
chr24_+_15897717 1.95 ENSDART00000105956
neto1l
neuropilin (NRP) and tolloid (TLL)-like 1, like
chr5_-_18897482 1.95 ENSDART00000010101
ENSDART00000099434
aacs
acetoacetyl-CoA synthetase
chr5_+_68112194 1.95 ENSDART00000162468
CABZ01083937.1

chr1_+_37391716 1.91 ENSDART00000191986
sparcl1
SPARC-like 1
chr21_+_26720803 1.89 ENSDART00000053797
slc3a2b
solute carrier family 3 (amino acid transporter heavy chain), member 2b
chr10_+_22134606 1.88 ENSDART00000155228
si:dkey-4c2.11
si:dkey-4c2.11
chr3_+_54047342 1.87 ENSDART00000178486
olfm2a
olfactomedin 2a
chr7_+_58686860 1.86 ENSDART00000052332
penkb
proenkephalin b
chr25_-_20258508 1.85 ENSDART00000133860
ENSDART00000006840
ENSDART00000173434
dnm1l
dynamin 1-like
chr16_-_45398408 1.84 ENSDART00000004052
rgl2
ral guanine nucleotide dissociation stimulator-like 2
chr11_-_4220167 1.82 ENSDART00000185406
si:ch211-236d3.4
si:ch211-236d3.4
chr20_-_39273987 1.81 ENSDART00000127173
clu
clusterin
chr21_+_1568044 1.80 ENSDART00000193570
ENSDART00000151601
rab27b
RAB27B, member RAS oncogene family
chr14_+_6429399 1.79 ENSDART00000149783
ENSDART00000148461
abca1b
ATP-binding cassette, sub-family A (ABC1), member 1B
chr11_+_13224281 1.78 ENSDART00000102557
ENSDART00000178706
abcb11b
ATP-binding cassette, sub-family B (MDR/TAP), member 11b
chr17_-_2834764 1.78 ENSDART00000024027
bdkrb1
bradykinin receptor B1
chr1_-_2334254 1.76 ENSDART00000144500
si:ch211-235f1.3
si:ch211-235f1.3
chr25_-_17395315 1.74 ENSDART00000064596
cyp2x8
cytochrome P450, family 2, subfamily X, polypeptide 8
chr19_+_17385561 1.74 ENSDART00000141397
ENSDART00000143913
ENSDART00000133626
rpl15
ribosomal protein L15
chr7_-_38634845 1.73 ENSDART00000173861
c1qtnf4
C1q and TNF related 4
chr23_-_8373676 1.72 ENSDART00000105135
ENSDART00000158531
oprl1
opiate receptor-like 1
chr20_+_6493648 1.71 ENSDART00000099846
mep1b
meprin A, beta
chr8_+_52503340 1.70 ENSDART00000168838
si:ch1073-392o20.1
si:ch1073-392o20.1
chr20_+_29586529 1.70 ENSDART00000178617
adam17b
ADAM metallopeptidase domain 17b
chr12_-_26587231 1.70 ENSDART00000153168
slc16a5a
solute carrier family 16 (monocarboxylate transporter), member 5a
chr16_-_27749172 1.66 ENSDART00000145198
steap4
STEAP family member 4
chr18_+_6479963 1.65 ENSDART00000092752
ENSDART00000136333
wash1
WAS protein family homolog 1
chr16_+_32059785 1.62 ENSDART00000134459
si:dkey-40m6.8
si:dkey-40m6.8
chr6_+_22068589 1.61 ENSDART00000151205
aldh1l1
aldehyde dehydrogenase 1 family, member L1
chr16_+_5774977 1.60 ENSDART00000134202
ccka
cholecystokinin a
chr15_-_31067589 1.59 ENSDART00000060157
lgals9l3
lectin, galactoside-binding, soluble, 9 (galectin 9)-like 3
chr24_-_38113208 1.57 ENSDART00000079003
crp
c-reactive protein, pentraxin-related
chr25_+_6186823 1.56 ENSDART00000153526
oaz2a
ornithine decarboxylase antizyme 2a
chr5_-_33886495 1.55 ENSDART00000159058
dab2ipb
DAB2 interacting protein b
chr5_+_1911814 1.53 ENSDART00000172233
si:ch73-55i23.1
si:ch73-55i23.1
chr6_+_2195625 1.53 ENSDART00000155659
acvr1bb
activin A receptor type 1Bb
chr14_+_8328645 1.53 ENSDART00000127494
nrg2b
neuregulin 2b
chr14_+_6159356 1.52 ENSDART00000157730
bscl2l
Bernardinelli-Seip congenital lipodystrophy 2, like
chr8_-_34065573 1.52 ENSDART00000186946
pbx3b
pre-B-cell leukemia homeobox 3b
chr1_+_41454210 1.52 ENSDART00000148251
si:ch211-89o9.4
si:ch211-89o9.4
chr19_-_31042570 1.52 ENSDART00000144337
ENSDART00000136213
ENSDART00000133101
ENSDART00000190949
bzw2
basic leucine zipper and W2 domains 2
chr17_+_27064158 1.51 ENSDART00000184864
ENSDART00000178734
ENSDART00000129273
rps6ka1
ribosomal protein S6 kinase a, polypeptide 1
chr5_+_36768674 1.51 ENSDART00000146854
mark4a
MAP/microtubule affinity-regulating kinase 4a
chr9_-_54304684 1.49 ENSDART00000109512
il13
interleukin 13
chr13_+_24552254 1.48 ENSDART00000147907
lgalslb
lectin, galactoside-binding-like b
chr8_+_36948256 1.48 ENSDART00000140410
iqsec2b
IQ motif and Sec7 domain 2b
chr19_-_20114149 1.46 ENSDART00000052620
npy
neuropeptide Y
chr11_+_13223625 1.45 ENSDART00000161275
abcb11b
ATP-binding cassette, sub-family B (MDR/TAP), member 11b
chr24_-_22702017 1.43 ENSDART00000179403
ctnnd2a
catenin (cadherin-associated protein), delta 2a
chr3_+_24511959 1.42 ENSDART00000133898
dnal4a
dynein, axonemal, light chain 4a
chr21_+_15870752 1.42 ENSDART00000122015
fam169ab
family with sequence similarity 169, member Ab
chr9_+_6079528 1.41 ENSDART00000142167
st6gal2a
ST6 beta-galactosamide alpha-2,6-sialyltranferase 2a
chr10_+_17776981 1.40 ENSDART00000141693
ccl19b
chemokine (C-C motif) ligand 19b
chr23_-_1571682 1.39 ENSDART00000013635
fbxo30b
F-box protein 30b
chr6_+_6491013 1.36 ENSDART00000140827
bcl11ab
B cell CLL/lymphoma 11Ab
chr2_+_55199721 1.36 ENSDART00000016143
zmp:0000000521
zmp:0000000521
chr21_-_30545121 1.36 ENSDART00000019199
rab39ba
RAB39B, member RAS oncogene family a
chr24_-_11905911 1.35 ENSDART00000033621
tm9sf1
transmembrane 9 superfamily member 1
chr9_+_29585943 1.34 ENSDART00000185989
ENSDART00000115290
mcf2lb
mcf.2 cell line derived transforming sequence-like b
chr1_-_21599219 1.32 ENSDART00000148327
adamtsl7
ADAMTS-like 7
chr18_-_6460102 1.31 ENSDART00000137037
iqsec3b
IQ motif and Sec7 domain 3b
chr13_-_11644806 1.30 ENSDART00000169953
dctn1b
dynactin 1b
chr11_+_43401201 1.29 ENSDART00000190128
vipb
vasoactive intestinal peptide b
chr4_+_19534833 1.29 ENSDART00000140028
lrrc4.1
leucine rich repeat containing 4.1
chr4_+_76575585 1.27 ENSDART00000131588
ms4a17a.11
membrane-spanning 4-domains, subfamily A, member 17A.11
chr4_+_359970 1.26 ENSDART00000139832
tmem181
transmembrane protein 181
chr3_-_49110710 1.26 ENSDART00000160404
trim35-12
tripartite motif containing 35-12
chr18_-_46135927 1.25 ENSDART00000134537
ENSDART00000191481
SPTBN4
si:ch73-262h23.4
chr15_-_30832897 1.25 ENSDART00000152330
msi2b
musashi RNA-binding protein 2b
chr4_-_9810999 1.24 ENSDART00000146858
si:dkeyp-27e10.3
si:dkeyp-27e10.3
chr21_-_22676323 1.23 ENSDART00000167392
gig2h
grass carp reovirus (GCRV)-induced gene 2h
chr12_-_46112892 1.22 ENSDART00000187128
ENSDART00000114268
zgc:153932
zgc:153932
chr24_+_22056386 1.22 ENSDART00000132390
ankrd33ba
ankyrin repeat domain 33ba
chr13_-_37608441 1.21 ENSDART00000140230
zgc:123068
zgc:123068
chr1_-_6085750 1.20 ENSDART00000138891
si:ch1073-345a8.1
si:ch1073-345a8.1
chr9_-_18877597 1.19 ENSDART00000099446
kctd4
potassium channel tetramerization domain containing 4
chr19_+_41701660 1.19 ENSDART00000033362
gatad2b
GATA zinc finger domain containing 2B
chr8_+_53452681 1.19 ENSDART00000166705
cacna1db
calcium channel, voltage-dependent, L type, alpha 1D subunit, b
chr19_-_17385548 1.18 ENSDART00000162383
nkiras1
NFKB inhibitor interacting Ras-like 1
chr13_+_33117528 1.17 ENSDART00000085719
si:ch211-10a23.2
si:ch211-10a23.2
chr7_+_39706004 1.17 ENSDART00000161856
ccl36.1
chemokine (C-C motif) ligand 36, duplicate 1
chr3_+_19621034 1.17 ENSDART00000025358
itgb3a
integrin beta 3a
chr20_+_34933183 1.17 ENSDART00000062738
snap25a
synaptosomal-associated protein, 25a
chr5_-_40190949 1.16 ENSDART00000175588
wdfy3
WD repeat and FYVE domain containing 3
chr1_-_46343999 1.15 ENSDART00000145117
ENSDART00000193233
atp11a
ATPase phospholipid transporting 11A
chr13_-_2112008 1.15 ENSDART00000110814
fam83b
family with sequence similarity 83, member B
chr18_+_13792490 1.12 ENSDART00000136754
cdh13
cadherin 13, H-cadherin (heart)
chr20_-_25412181 1.12 ENSDART00000062780
itsn2a
intersectin 2a
chr22_+_20427170 1.12 ENSDART00000136744
foxq2
forkhead box Q2
chr9_+_6934491 1.10 ENSDART00000114323
mfsd9
major facilitator superfamily domain containing 9
chr7_-_36358303 1.10 ENSDART00000130028
fto
fat mass and obesity associated
chr24_+_13635387 1.10 ENSDART00000105997
trpa1b
transient receptor potential cation channel, subfamily A, member 1b
chr19_-_35596207 1.10 ENSDART00000136811
col8a2
collagen, type VIII, alpha 2
chr13_+_40019001 1.09 ENSDART00000158820
golga7bb
golgin A7 family, member Bb
chr11_-_27962757 1.09 ENSDART00000147386
ece1
endothelin converting enzyme 1
chr9_-_5045378 1.08 ENSDART00000149268
nr4a2a
nuclear receptor subfamily 4, group A, member 2a
chr19_-_6631900 1.07 ENSDART00000144571
pvrl2l
poliovirus receptor-related 2 like
chr10_+_21722892 1.07 ENSDART00000162855
pcdh1g13
protocadherin 1 gamma 13
chr14_+_16345003 1.06 ENSDART00000003040
ENSDART00000165193
itln3
intelectin 3
chr19_-_26235219 1.05 ENSDART00000104008
dtnbp1b
dystrobrevin binding protein 1b
chr23_+_10469955 1.04 ENSDART00000140557
tns2a
tensin 2a
chr5_-_42883761 1.03 ENSDART00000167374
BX323596.2

chr7_-_36358735 1.03 ENSDART00000188392
fto
fat mass and obesity associated
chr15_-_568645 1.02 ENSDART00000156744
cbln18
cerebellin 18
chr5_+_20148671 1.02 ENSDART00000143205
svopa
SV2 related protein a
chr4_+_76637548 1.02 ENSDART00000133799
ms4a17a.9
membrane-spanning 4-domains, subfamily A, member 17A.9
chr8_-_31701157 0.99 ENSDART00000141799
fbxo4
F-box protein 4
chr13_+_24750078 0.99 ENSDART00000021053
col17a1b
collagen, type XVII, alpha 1b
chr14_+_33329420 0.98 ENSDART00000171090
ENSDART00000164062
sowahd
sosondowah ankyrin repeat domain family d
chr4_+_76735113 0.98 ENSDART00000075602
ms4a17a.6
membrane-spanning 4-domains, subfamily A, member 17A.6
chr7_-_2175181 0.97 ENSDART00000174011
si:cabz01007812.1
si:cabz01007812.1
chr7_+_30867008 0.97 ENSDART00000193106
apba2b
amyloid beta (A4) precursor protein-binding, family A, member 2b
chr7_-_20241346 0.97 ENSDART00000173619
ENSDART00000127699
si:ch73-335l21.4
si:ch73-335l21.4
chr17_-_26604946 0.97 ENSDART00000087062
fam149b1
family with sequence similarity 149, member B1
chr3_-_13461361 0.97 ENSDART00000080807
fbxw9
F-box and WD repeat domain containing 9
chr9_-_12443726 0.95 ENSDART00000102434
ehhadh
enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
chr14_-_2202652 0.94 ENSDART00000171316
si:dkey-262j3.7
si:dkey-262j3.7
chr6_+_18321627 0.94 ENSDART00000183107
ENSDART00000189715
card14
caspase recruitment domain family, member 14
chr1_-_46981134 0.94 ENSDART00000130607
pknox1.2
pbx/knotted 1 homeobox 1.2
chr5_+_25952340 0.93 ENSDART00000147188
trpm3
transient receptor potential cation channel, subfamily M, member 3
chr11_-_18800299 0.92 ENSDART00000156276
pfkfb2b
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2b
chr6_+_9870192 0.91 ENSDART00000150894
MPP4 (1 of many)
si:ch211-222n4.6
chr13_-_40238813 0.90 ENSDART00000044963
loxl4
lysyl oxidase-like 4
chr18_+_3332999 0.90 ENSDART00000160857
gdpd4a
glycerophosphodiester phosphodiesterase domain containing 4a

Network of associatons between targets according to the STRING database.

First level regulatory network of stat1a+stat2-1_stat1b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 12.6 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
1.7 5.1 GO:0070314 G1 to G0 transition(GO:0070314)
1.1 4.3 GO:0018171 peptidyl-cysteine oxidation(GO:0018171)
1.0 3.9 GO:0043084 copulation(GO:0007620) regulation of epinephrine secretion(GO:0014060) positive regulation of epinephrine secretion(GO:0032812) positive regulation of catecholamine secretion(GO:0033605) penile erection(GO:0043084) epinephrine transport(GO:0048241) epinephrine secretion(GO:0048242) regulation of penile erection(GO:0060405) positive regulation of penile erection(GO:0060406) prolactin secretion(GO:0070459)
0.8 3.4 GO:0010812 negative regulation of cell-substrate adhesion(GO:0010812) negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.8 3.2 GO:0032782 canalicular bile acid transport(GO:0015722) bile acid secretion(GO:0032782)
0.8 5.5 GO:0034389 lipid particle organization(GO:0034389)
0.7 2.1 GO:0042245 RNA repair(GO:0042245)
0.6 2.5 GO:0002532 production of molecular mediator involved in inflammatory response(GO:0002532)
0.6 4.7 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889)
0.5 1.6 GO:0009256 10-formyltetrahydrofolate metabolic process(GO:0009256) 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
0.5 2.9 GO:0042427 serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.4 1.7 GO:0015677 copper ion import(GO:0015677)
0.4 4.5 GO:0050688 regulation of defense response to virus(GO:0050688)
0.4 1.9 GO:1903146 regulation of mitophagy(GO:1903146)
0.4 1.5 GO:0045938 positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.4 2.8 GO:0043330 response to exogenous dsRNA(GO:0043330)
0.3 2.0 GO:0030242 pexophagy(GO:0030242)
0.3 1.4 GO:2000171 negative regulation of dendrite development(GO:2000171)
0.3 1.6 GO:0032689 negative regulation of interferon-gamma production(GO:0032689) CD4-positive, alpha-beta T cell proliferation(GO:0035739) regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000561) negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
0.3 0.9 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.3 4.1 GO:0016540 protein autoprocessing(GO:0016540)
0.3 0.9 GO:0097052 L-kynurenine metabolic process(GO:0097052) L-kynurenine catabolic process(GO:0097053)
0.3 0.9 GO:0001562 response to protozoan(GO:0001562) defense response to protozoan(GO:0042832)
0.3 0.8 GO:0006678 glucosylceramide metabolic process(GO:0006678)
0.3 7.0 GO:0030322 stabilization of membrane potential(GO:0030322)
0.3 2.7 GO:0072506 phosphate ion homeostasis(GO:0055062) trivalent inorganic anion homeostasis(GO:0072506)
0.3 1.1 GO:0060155 secretory granule organization(GO:0033363) platelet dense granule organization(GO:0060155)
0.3 0.8 GO:1905072 cardiac jelly development(GO:1905072)
0.2 1.4 GO:2000576 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.2 0.7 GO:0070278 extracellular matrix constituent secretion(GO:0070278)
0.2 0.7 GO:0002468 dendritic cell antigen processing and presentation(GO:0002468)
0.2 0.9 GO:1904353 positive regulation of telomere maintenance(GO:0032206) regulation of telomere capping(GO:1904353) positive regulation of telomere capping(GO:1904355)
0.2 0.6 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631) regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.2 2.0 GO:0032024 positive regulation of insulin secretion(GO:0032024)
0.2 1.5 GO:0038026 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948) reelin-mediated signaling pathway(GO:0038026)
0.2 3.2 GO:0006825 copper ion transport(GO:0006825)
0.2 0.6 GO:0046415 urate catabolic process(GO:0019628) urate metabolic process(GO:0046415)
0.2 1.8 GO:0033700 phospholipid efflux(GO:0033700)
0.2 1.9 GO:0060142 regulation of syncytium formation by plasma membrane fusion(GO:0060142)
0.2 5.8 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.2 5.2 GO:0017121 phospholipid scrambling(GO:0017121)
0.1 1.1 GO:1902262 apoptotic process involved in patterning of blood vessels(GO:1902262)
0.1 0.6 GO:0034653 vitamin catabolic process(GO:0009111) diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653) fat-soluble vitamin catabolic process(GO:0042363)
0.1 1.1 GO:0071376 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.1 0.7 GO:0005513 detection of calcium ion(GO:0005513)
0.1 0.6 GO:0036498 IRE1-mediated unfolded protein response(GO:0036498)
0.1 0.4 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.1 1.0 GO:0006842 tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746)
0.1 2.1 GO:0040023 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.1 3.1 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 0.4 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 2.0 GO:0048168 regulation of neuronal synaptic plasticity(GO:0048168)
0.1 1.2 GO:0070527 platelet aggregation(GO:0070527)
0.1 1.2 GO:0021988 olfactory bulb development(GO:0021772) olfactory lobe development(GO:0021988)
0.1 0.2 GO:0097676 histone H3-K4 trimethylation(GO:0080182) histone H3-K36 dimethylation(GO:0097676)
0.1 2.0 GO:0031114 regulation of microtubule depolymerization(GO:0031114)
0.1 3.0 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.1 6.7 GO:0008045 motor neuron axon guidance(GO:0008045)
0.1 0.8 GO:0034340 response to type I interferon(GO:0034340) type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.1 1.1 GO:0016486 peptide hormone processing(GO:0016486)
0.1 0.5 GO:0030194 positive regulation of blood coagulation(GO:0030194) positive regulation of coagulation(GO:0050820) positive regulation of hemostasis(GO:1900048)
0.1 0.5 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.1 1.0 GO:0008053 mitochondrial fusion(GO:0008053)
0.1 0.3 GO:0060092 regulation of synaptic transmission, glycinergic(GO:0060092)
0.1 0.6 GO:0001541 ovarian follicle development(GO:0001541) ovulation cycle process(GO:0022602) ovulation cycle(GO:0042698)
0.1 1.6 GO:0006595 polyamine metabolic process(GO:0006595)
0.1 2.7 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.1 3.0 GO:0003009 skeletal muscle contraction(GO:0003009)
0.1 1.5 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.1 2.8 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 0.9 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.1 1.7 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.1 0.9 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 1.8 GO:0071222 cellular response to molecule of bacterial origin(GO:0071219) cellular response to lipopolysaccharide(GO:0071222)
0.1 1.7 GO:0045332 phospholipid translocation(GO:0045332)
0.0 1.4 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.0 1.8 GO:0032402 melanosome transport(GO:0032402) pigment granule transport(GO:0051904)
0.0 2.6 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 0.8 GO:0015914 phospholipid transport(GO:0015914)
0.0 1.2 GO:0045879 negative regulation of smoothened signaling pathway(GO:0045879)
0.0 1.4 GO:0032482 Rab protein signal transduction(GO:0032482)
0.0 1.7 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 0.8 GO:1990035 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.0 4.7 GO:0007269 neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643)
0.0 0.7 GO:0018216 peptidyl-arginine methylation(GO:0018216)
0.0 0.0 GO:0030889 negative regulation of B cell proliferation(GO:0030889) negative regulation of B cell activation(GO:0050869)
0.0 0.4 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.0 0.1 GO:0061355 Wnt protein secretion(GO:0061355)
0.0 1.6 GO:0051262 protein tetramerization(GO:0051262)
0.0 0.6 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.0 3.6 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 1.5 GO:0032924 activin receptor signaling pathway(GO:0032924)
0.0 1.6 GO:0017144 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.0 2.6 GO:0030042 actin filament depolymerization(GO:0030042)
0.0 5.8 GO:0006814 sodium ion transport(GO:0006814)
0.0 0.2 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.0 0.6 GO:0071456 cellular response to hypoxia(GO:0071456)
0.0 1.9 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 1.1 GO:0038127 epidermal growth factor receptor signaling pathway(GO:0007173) ERBB signaling pathway(GO:0038127)
0.0 1.8 GO:0051017 actin filament bundle assembly(GO:0051017)
0.0 4.9 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.5 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.5 GO:0032438 melanosome organization(GO:0032438)
0.0 0.9 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.0 0.1 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.1 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520) monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.0 0.2 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 2.2 GO:0042594 response to starvation(GO:0042594)
0.0 0.5 GO:0055064 chloride ion homeostasis(GO:0055064)
0.0 2.6 GO:0008654 phospholipid biosynthetic process(GO:0008654)
0.0 1.1 GO:0007602 phototransduction(GO:0007602)
0.0 0.7 GO:0010921 regulation of phosphatase activity(GO:0010921)
0.0 0.9 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.3 GO:0018158 protein oxidation(GO:0018158)
0.0 0.3 GO:0098962 regulation of postsynaptic neurotransmitter receptor activity(GO:0098962)
0.0 1.0 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.0 1.2 GO:0006469 negative regulation of protein kinase activity(GO:0006469)
0.0 0.2 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.0 0.8 GO:0048821 erythrocyte development(GO:0048821)
0.0 0.1 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.0 0.8 GO:1901214 regulation of neuron death(GO:1901214)
0.0 1.0 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.5 GO:0010107 potassium ion import(GO:0010107) potassium ion import across plasma membrane(GO:1990573)
0.0 0.4 GO:0003094 glomerular filtration(GO:0003094)
0.0 0.0 GO:0071678 olfactory bulb axon guidance(GO:0071678)
0.0 0.1 GO:0002551 mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0 0.2 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.3 GO:0048264 determination of ventral identity(GO:0048264)
0.0 0.2 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.2 GO:0003373 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) postsynaptic neurotransmitter receptor internalization(GO:0098884)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 0.6 GO:0030055 cell-substrate junction(GO:0030055)
0.6 4.7 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.5 8.3 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.3 14.9 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.2 0.7 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) anchored component of the cytoplasmic side of the plasma membrane(GO:0098753)
0.2 1.2 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.2 0.6 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.2 1.8 GO:0042583 chromaffin granule(GO:0042583)
0.1 2.7 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.1 1.5 GO:0048179 activin receptor complex(GO:0048179)
0.1 9.8 GO:0005581 collagen trimer(GO:0005581)
0.1 0.5 GO:0071203 WASH complex(GO:0071203)
0.1 3.9 GO:0043204 perikaryon(GO:0043204)
0.1 0.7 GO:0016586 RSC complex(GO:0016586)
0.1 6.2 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 3.3 GO:0005758 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.1 1.8 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 0.4 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1 4.2 GO:0016342 catenin complex(GO:0016342)
0.1 1.1 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.1 3.0 GO:0005861 troponin complex(GO:0005861)
0.1 4.8 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 1.2 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 2.3 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 0.7 GO:0016580 Sin3 complex(GO:0016580)
0.1 1.1 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1 1.9 GO:0044306 axon terminus(GO:0043679) neuron projection terminus(GO:0044306)
0.1 7.6 GO:0016324 apical plasma membrane(GO:0016324)
0.1 0.7 GO:0005922 connexon complex(GO:0005922)
0.0 1.3 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.6 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 0.4 GO:0070449 elongin complex(GO:0070449)
0.0 0.9 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 1.2 GO:0005844 polysome(GO:0005844)
0.0 0.9 GO:0019814 immunoglobulin complex(GO:0019814)
0.0 1.1 GO:0042734 presynaptic membrane(GO:0042734)
0.0 3.9 GO:0008021 synaptic vesicle(GO:0008021)
0.0 0.5 GO:0005865 striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
0.0 4.1 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 6.9 GO:0005912 adherens junction(GO:0005912)
0.0 2.0 GO:0043025 neuronal cell body(GO:0043025)
0.0 0.2 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 1.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.3 GO:0030128 clathrin coat of endocytic vesicle(GO:0030128) clathrin-coated endocytic vesicle membrane(GO:0030669)
0.0 0.2 GO:0030897 HOPS complex(GO:0030897)
0.0 1.4 GO:0030286 dynein complex(GO:0030286)
0.0 0.6 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.1 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.4 GO:0016282 eukaryotic 43S preinitiation complex(GO:0016282)
0.0 1.7 GO:0055037 recycling endosome(GO:0055037)
0.0 0.8 GO:0098978 glutamatergic synapse(GO:0098978)
0.0 0.8 GO:0042383 sarcolemma(GO:0042383)
0.0 0.3 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.7 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 0.2 GO:0031306 intrinsic component of mitochondrial outer membrane(GO:0031306)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 8.0 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.8 4.1 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.8 3.2 GO:0015432 canalicular bile acid transmembrane transporter activity(GO:0015126) bile acid-exporting ATPase activity(GO:0015432)
0.7 3.3 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.6 3.2 GO:0016531 copper chaperone activity(GO:0016531)
0.6 4.3 GO:0016972 thiol oxidase activity(GO:0016972)
0.6 4.7 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.6 2.9 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.5 1.6 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.5 2.1 GO:0035516 oxidative DNA demethylase activity(GO:0035516) DNA-N1-methyladenine dioxygenase activity(GO:0043734) RNA N6-methyladenosine dioxygenase activity(GO:1990931)
0.5 14.9 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.4 2.2 GO:0031769 glucagon receptor binding(GO:0031769)
0.4 5.2 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.4 1.7 GO:0052851 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.4 8.3 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.4 1.6 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.4 1.2 GO:0070051 fibrinogen binding(GO:0070051)
0.4 1.8 GO:0090556 phospholipid-translocating ATPase activity(GO:0004012) phosphatidylcholine-translocating ATPase activity(GO:0090554) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.3 0.9 GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.3 1.9 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427) calcium-dependent protein kinase regulator activity(GO:0010858)
0.3 1.5 GO:0031843 neuropeptide Y receptor binding(GO:0031841) type 2 neuropeptide Y receptor binding(GO:0031843)
0.3 7.0 GO:0022841 leak channel activity(GO:0022840) potassium ion leak channel activity(GO:0022841) narrow pore channel activity(GO:0022842)
0.3 2.1 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.3 1.5 GO:0016361 activin receptor activity, type I(GO:0016361)
0.3 1.0 GO:0017153 sodium:dicarboxylate symporter activity(GO:0017153)
0.2 1.9 GO:0031628 opioid receptor binding(GO:0031628)
0.2 1.7 GO:0004985 opioid receptor activity(GO:0004985)
0.2 3.9 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.2 1.4 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.2 3.9 GO:0001540 beta-amyloid binding(GO:0001540)
0.2 0.5 GO:0031716 calcitonin receptor binding(GO:0031716)
0.2 2.7 GO:0004382 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.1 0.6 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.1 4.2 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 1.5 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.1 1.7 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 0.7 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.1 1.5 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.1 0.5 GO:0101006 inorganic diphosphatase activity(GO:0004427) protein histidine phosphatase activity(GO:0101006)
0.1 0.9 GO:0015168 glycerol transmembrane transporter activity(GO:0015168)
0.1 2.8 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 1.1 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 0.7 GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.1 0.9 GO:0050700 CARD domain binding(GO:0050700)
0.1 2.7 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 0.7 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.1 0.7 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1 0.6 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.1 3.7 GO:0042826 histone deacetylase binding(GO:0042826)
0.1 0.6 GO:0001972 retinoic acid binding(GO:0001972)
0.1 2.0 GO:0016878 acid-thiol ligase activity(GO:0016878)
0.1 0.8 GO:0008422 beta-glucosidase activity(GO:0008422)
0.1 0.6 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.1 0.9 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 0.3 GO:0004968 gonadotropin-releasing hormone receptor activity(GO:0004968)
0.1 1.5 GO:0050321 tau-protein kinase activity(GO:0050321)
0.1 1.8 GO:0051787 misfolded protein binding(GO:0051787)
0.1 0.9 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.1 2.7 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.1 0.5 GO:0015057 thrombin receptor activity(GO:0015057)
0.1 1.4 GO:0070492 oligosaccharide binding(GO:0070492)
0.1 0.2 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.1 0.8 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.1 1.7 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.1 1.6 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 7.4 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 0.5 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 1.9 GO:0005518 collagen binding(GO:0005518)
0.1 0.3 GO:0050254 rhodopsin kinase activity(GO:0050254)
0.1 1.6 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.1 0.2 GO:0033857 inositol heptakisphosphate kinase activity(GO:0000829) diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.1 5.0 GO:0045296 cadherin binding(GO:0045296)
0.0 4.8 GO:0005179 hormone activity(GO:0005179)
0.0 0.1 GO:0003913 DNA photolyase activity(GO:0003913)
0.0 4.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.4 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 2.6 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 6.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.7 GO:0008009 chemokine activity(GO:0008009) chemokine receptor binding(GO:0042379)
0.0 0.3 GO:0048019 receptor antagonist activity(GO:0048019)
0.0 0.7 GO:0030552 cAMP binding(GO:0030552)
0.0 0.7 GO:0035497 cAMP response element binding(GO:0035497)
0.0 1.3 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.4 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.0 1.6 GO:0015485 cholesterol binding(GO:0015485)
0.0 1.2 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.3 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
0.0 0.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 4.1 GO:0000287 magnesium ion binding(GO:0000287)
0.0 1.6 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.0 2.5 GO:0019838 growth factor binding(GO:0019838)
0.0 1.1 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 1.1 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.9 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.0 1.8 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.4 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.0 0.3 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 0.3 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.0 15.9 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.6 GO:0005178 integrin binding(GO:0005178)
0.0 0.3 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.1 GO:1903924 estradiol binding(GO:1903924)
0.0 6.9 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 1.9 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 0.3 GO:0070411 I-SMAD binding(GO:0070411)
0.0 3.1 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.8 GO:0004497 monooxygenase activity(GO:0004497)
0.0 0.2 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.4 GO:0046332 SMAD binding(GO:0046332)
0.0 0.0 GO:0070738 protein-glycine ligase activity(GO:0070735) tubulin-glycine ligase activity(GO:0070738)
0.0 1.6 GO:0008083 growth factor activity(GO:0008083)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 6.7 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.2 1.5 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.2 8.3 NABA COLLAGENS Genes encoding collagen proteins
0.1 2.1 PID CONE PATHWAY Visual signal transduction: Cones
0.1 1.5 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 0.3 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 3.0 PID IL2 1PATHWAY IL2-mediated signaling events
0.0 0.3 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.6 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.0 1.9 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 0.6 PID RHOA PATHWAY RhoA signaling pathway
0.0 2.0 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.2 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 0.4 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 0.8 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.3 PID TXA2PATHWAY Thromboxane A2 receptor signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 9.7 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.4 7.2 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.3 0.9 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.2 4.7 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.2 7.9 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.2 1.8 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 1.5 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS Genes involved in CREB phosphorylation through the activation of Ras
0.1 1.3 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 4.8 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 1.1 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.6 REACTOME APOPTOTIC EXECUTION PHASE Genes involved in Apoptotic execution phase
0.0 0.7 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.7 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 1.7 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.0 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.6 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 0.8 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.2 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.3 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.4 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.3 REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.0 1.0 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 1.7 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.4 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription