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PRJEB1986: zebrafish developmental stages transcriptome

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Results for tbx20

Z-value: 1.01

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Transcription factors associated with tbx20

Gene Symbol Gene ID Gene Info
tbx20
ENSDARG00000005150 T-box transcription factor 20

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tbx20dr11_v1_chr16_-_42523744_425237440.633.9e-03Click!

Activity profile of tbx20 motif

Sorted Z-values of tbx20 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr13_-_293250 8.48 ENSDART00000138581
chs1
chitin synthase 1
chr5_+_32228538 3.34 ENSDART00000077471
myhc4
myosin heavy chain 4
chr25_+_37285737 3.19 ENSDART00000126879
tmed6
transmembrane p24 trafficking protein 6
chr24_+_42948 3.19 ENSDART00000122785
tmx3b
thioredoxin related transmembrane protein 3b
chr15_+_43799258 3.07 ENSDART00000122238
tyr
tyrosinase
chr21_+_5494561 2.64 ENSDART00000169728
ly6m3
lymphocyte antigen 6 family member M3
chr12_+_49100365 2.19 ENSDART00000171905
CABZ01075125.1

chr8_-_11112058 2.11 ENSDART00000042755
ampd1
adenosine monophosphate deaminase 1 (isoform M)
chr12_+_1286642 1.70 ENSDART00000157467
pemt
phosphatidylethanolamine N-methyltransferase
chr25_+_37130450 1.64 ENSDART00000183358
si:ch1073-174d20.1
si:ch1073-174d20.1
chr18_+_10929661 1.59 ENSDART00000061838
ENSDART00000113146
ttc38
tetratricopeptide repeat domain 38
chr21_-_2273244 1.53 ENSDART00000171417
si:ch73-299h12.3
si:ch73-299h12.3
chr5_-_36549024 1.52 ENSDART00000097671
zgc:158432
zgc:158432
chr11_-_26832685 1.47 ENSDART00000153519
iqsec1b
IQ motif and Sec7 domain 1b
chr23_-_29668286 1.45 ENSDART00000129248
clstn1
calsyntenin 1
chr8_-_42677086 1.42 ENSDART00000191173
si:ch73-138n13.1
si:ch73-138n13.1
chr6_-_18751696 1.41 ENSDART00000171537
tnrc6c2
trinucleotide repeat containing 6C2
chr7_+_39389273 1.38 ENSDART00000191298
tnni2b.2
troponin I type 2b (skeletal, fast), tandem duplicate 2
chr25_-_35107791 1.37 ENSDART00000192819
zgc:165555
zgc:165555
chr5_+_9382301 1.36 ENSDART00000124017
ugt2a7
UDP glucuronosyltransferase 2 family, polypeptide A7
chr2_-_57076687 1.35 ENSDART00000161523
slc25a42
solute carrier family 25, member 42
chr1_-_59360114 1.33 ENSDART00000160445
CABZ01052573.1

chr20_-_116999 1.33 ENSDART00000149581
ypel5
yippee-like 5
chr13_+_18276187 1.32 ENSDART00000141009
tet1
tet methylcytosine dioxygenase 1
chr19_+_177455 1.32 ENSDART00000111580
tmem65
transmembrane protein 65
chr12_+_3848109 1.29 ENSDART00000144067
ENSDART00000192042
cabp5a
calcium binding protein 5a
chr8_+_50983551 1.23 ENSDART00000142061
si:dkey-32e23.4
si:dkey-32e23.4
chr1_-_46326156 1.20 ENSDART00000040284
atp11a
ATPase phospholipid transporting 11A
chr24_-_41220538 1.20 ENSDART00000150207
acvr2ba
activin A receptor type 2Ba
chr20_-_31808779 1.19 ENSDART00000133788
stxbp5a
syntaxin binding protein 5a (tomosyn)
chr8_+_68864 1.14 ENSDART00000164574
prr16
proline rich 16
chr9_-_32912638 1.13 ENSDART00000110582
fam160a2
family with sequence similarity 160, member A2
chr18_-_51015718 1.11 ENSDART00000190698
LO018598.1

chr20_+_826459 1.10 ENSDART00000104740
nt5e
5'-nucleotidase, ecto (CD73)
chr23_-_45049044 1.09 ENSDART00000067630
SH3GL2 (1 of many)
SH3 domain containing GRB2 like 2, endophilin A1
chr6_-_49537646 1.03 ENSDART00000180438
FO704848.1

chr3_+_25857008 1.03 ENSDART00000154899
ENSDART00000193762
zgc:171844
zgc:171844
chr21_-_36948 1.03 ENSDART00000181230
JMY
junction mediating and regulatory protein, p53 cofactor
chr6_+_40587551 1.01 ENSDART00000155554
frs3
fibroblast growth factor receptor substrate 3
chr4_-_50207986 0.93 ENSDART00000150388
si:ch211-197e7.3
si:ch211-197e7.3
chr20_+_42246948 0.84 ENSDART00000061135
gopc
golgi-associated PDZ and coiled-coil motif containing
chr3_-_33417826 0.83 ENSDART00000084284
abi3a
ABI family, member 3a
chr21_+_1119046 0.79 ENSDART00000184678
CABZ01088049.1

chr22_-_37796998 0.79 ENSDART00000124742
ENSDART00000191232
acap2
ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
chr2_-_31301929 0.76 ENSDART00000191992
ENSDART00000190723
adcyap1b
adenylate cyclase activating polypeptide 1b
chr5_-_49012569 0.72 ENSDART00000184690
si:dkey-172m14.2
si:dkey-172m14.2
chr12_+_763051 0.69 ENSDART00000152579
abcc3
ATP-binding cassette, sub-family C (CFTR/MRP), member 3
chr8_+_36416285 0.64 ENSDART00000158400
si:busm1-194e12.8
si:busm1-194e12.8
chr21_-_12749501 0.63 ENSDART00000179724
LO018011.1

chr3_+_17314997 0.63 ENSDART00000139763
stat5a
signal transducer and activator of transcription 5a
chr7_-_69853453 0.62 ENSDART00000049928
myoz2a
myozenin 2a
chr12_-_48127985 0.57 ENSDART00000193805
npffr1
neuropeptide FF receptor 1
chr2_+_15776156 0.56 ENSDART00000190795
vav3b
vav 3 guanine nucleotide exchange factor b
chr24_+_41940299 0.55 ENSDART00000022349
epb41l3a
erythrocyte membrane protein band 4.1-like 3a
chr12_+_15290800 0.55 ENSDART00000145656
med1
mediator complex subunit 1
chr22_+_978867 0.53 ENSDART00000148981
def6b
differentially expressed in FDCP 6b homolog (mouse)
chr11_+_45299447 0.50 ENSDART00000172999
mafgb
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Gb
chr17_+_1496107 0.50 ENSDART00000187804
LO018430.1

chr25_+_19170500 0.39 ENSDART00000182572
BX294110.2

chr22_-_35385810 0.38 ENSDART00000111824
HTR3C
5-hydroxytryptamine receptor 3C
chr9_-_53537989 0.37 ENSDART00000114022
slitrk5b
SLIT and NTRK-like family, member 5b
chr11_-_44622240 0.35 ENSDART00000172258
ENSDART00000173340
tbce
tubulin folding cofactor E
chr13_-_10620652 0.34 ENSDART00000135000
ENSDART00000191587
si:ch73-54n14.2
camkmt
si:ch73-54n14.2
calmodulin-lysine N-methyltransferase
chr2_+_43469241 0.33 ENSDART00000142078
ENSDART00000098265
nrp1b
neuropilin 1b
chr1_-_462165 0.33 ENSDART00000152799
si:ch73-244f7.3
si:ch73-244f7.3
chr7_-_5070794 0.31 ENSDART00000097877
ltb4r2a
leukotriene B4 receptor 2a
chr3_-_47036951 0.28 ENSDART00000186971
CR392045.1

chr17_-_15600455 0.26 ENSDART00000110272
ENSDART00000156911
si:ch211-266g18.9
si:ch211-266g18.9
chr15_-_30714130 0.23 ENSDART00000156914
ENSDART00000154714
msi2b
musashi RNA-binding protein 2b
chr15_-_47479119 0.19 ENSDART00000164957
inppl1a
inositol polyphosphate phosphatase-like 1a
chr2_+_15776408 0.18 ENSDART00000176628
vav3b
vav 3 guanine nucleotide exchange factor b
chr16_-_563732 0.17 ENSDART00000183394
irx2a
iroquois homeobox 2a
chr4_+_35138928 0.14 ENSDART00000167934
ENSDART00000192116
ENSDART00000183689
si:dkey-279j5.1
si:dkey-279j5.1
chr15_-_30867594 0.13 ENSDART00000154448
nf1a
neurofibromin 1a
chr10_+_42589707 0.13 ENSDART00000075269
fgfr1b
fibroblast growth factor receptor 1b
chr13_-_31812394 0.12 ENSDART00000124445
sertad4
SERTA domain containing 4
chr25_-_7686201 0.11 ENSDART00000157267
ENSDART00000155094
si:ch211-286c4.6
si:ch211-286c4.6
chr4_-_75812937 0.10 ENSDART00000125096
si:ch211-203c5.3
si:ch211-203c5.3
chr14_-_33858214 0.09 ENSDART00000112268
ocrl
oculocerebrorenal syndrome of Lowe
chr13_-_48431766 0.07 ENSDART00000159688
ENSDART00000171765
fbxo11a
F-box protein 11a
chr23_-_27479558 0.06 ENSDART00000013563
atf7a
activating transcription factor 7a
chr3_+_52475058 0.04 ENSDART00000035867
si:ch211-241f5.3
si:ch211-241f5.3
chr6_+_7555614 0.01 ENSDART00000187590
myh10
myosin, heavy chain 10, non-muscle
chr20_+_2674992 0.01 ENSDART00000132917
slc35a1
solute carrier family 35 (CMP-sialic acid transporter), member A1

Network of associatons between targets according to the STRING database.

First level regulatory network of tbx20

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 8.5 GO:0006031 chitin biosynthetic process(GO:0006031) glucosamine-containing compound biosynthetic process(GO:1901073)
1.0 3.1 GO:0006585 dopamine biosynthetic process from tyrosine(GO:0006585) dopamine biosynthetic process(GO:0042416)
0.8 3.2 GO:0018171 peptidyl-cysteine oxidation(GO:0018171)
0.4 1.3 GO:1903779 regulation of cardiac conduction(GO:1903779)
0.4 1.4 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.3 0.8 GO:2000008 regulation of protein localization to cell surface(GO:2000008) negative regulation of protein localization to cell surface(GO:2000009)
0.3 1.3 GO:0032656 interleukin-13 production(GO:0032616) regulation of interleukin-13 production(GO:0032656)
0.2 1.2 GO:1903146 regulation of mitophagy(GO:1903146)
0.2 1.7 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.2 1.1 GO:0009128 purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.2 0.5 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.2 2.1 GO:0032264 IMP salvage(GO:0032264)
0.1 0.6 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504)
0.1 0.6 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.1 1.4 GO:0060213 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213) regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151) positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900153)
0.1 0.5 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.1 0.6 GO:1904861 excitatory synapse assembly(GO:1904861)
0.0 0.3 GO:0035767 endothelial cell chemotaxis(GO:0035767)
0.0 3.2 GO:0007030 Golgi organization(GO:0007030)
0.0 1.2 GO:0045332 phospholipid translocation(GO:0045332)
0.0 1.5 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.3 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 1.2 GO:0050708 regulation of protein secretion(GO:0050708)
0.0 1.3 GO:0007006 mitochondrial membrane organization(GO:0007006)
0.0 0.2 GO:1902623 negative regulation of leukocyte chemotaxis(GO:0002689) negative regulation of granulocyte chemotaxis(GO:0071623) negative regulation of neutrophil chemotaxis(GO:0090024) negative regulation of neutrophil migration(GO:1902623)
0.0 0.1 GO:0060251 regulation of glial cell proliferation(GO:0060251)
0.0 1.4 GO:0003009 skeletal muscle contraction(GO:0003009)
0.0 1.2 GO:0032924 activin receptor signaling pathway(GO:0032924)
0.0 0.1 GO:0071871 response to monoamine(GO:0071867) response to catecholamine(GO:0071869) response to epinephrine(GO:0071871)
0.0 0.3 GO:0018023 peptidyl-lysine trimethylation(GO:0018023)
0.0 0.2 GO:0021988 olfactory bulb development(GO:0021772) olfactory lobe development(GO:0021988)
0.0 1.4 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.8 GO:0032880 regulation of protein localization(GO:0032880)
0.0 0.2 GO:0039014 pronephric nephron tubule epithelial cell differentiation(GO:0035778) cell differentiation involved in pronephros development(GO:0039014)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 8.5 GO:0030428 cell septum(GO:0030428)
0.3 3.1 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1 1.2 GO:0048179 activin receptor complex(GO:0048179)
0.1 0.6 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 3.2 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 1.4 GO:0005861 troponin complex(GO:0005861)
0.0 0.8 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 3.4 GO:0016459 myosin complex(GO:0016459)
0.0 1.0 GO:0030175 filopodium(GO:0030175)
0.0 0.8 GO:0043204 perikaryon(GO:0043204)
0.0 1.4 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 1.1 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.2 GO:0031201 SNARE complex(GO:0031201)
0.0 1.4 GO:0000786 nucleosome(GO:0000786)
0.0 1.2 GO:0055037 recycling endosome(GO:0055037)
0.0 0.1 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 4.9 GO:0009986 cell surface(GO:0009986)
0.0 5.6 GO:0031966 mitochondrial membrane(GO:0031966)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 8.5 GO:0004100 chitin synthase activity(GO:0004100)
1.0 3.1 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.5 3.2 GO:0016972 thiol oxidase activity(GO:0016972)
0.4 1.3 GO:0015228 coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)
0.2 2.1 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.2 0.8 GO:0016521 pituitary adenylate cyclase activating polypeptide activity(GO:0016521)
0.2 1.3 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.1 0.5 GO:0042809 vitamin D receptor binding(GO:0042809)
0.1 1.2 GO:0017002 activin-activated receptor activity(GO:0017002)
0.1 1.2 GO:0045159 myosin II binding(GO:0045159)
0.1 0.6 GO:0051373 telethonin binding(GO:0031433) FATZ binding(GO:0051373)
0.1 1.1 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.3 GO:0004974 leukotriene receptor activity(GO:0004974)
0.0 0.3 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 1.4 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 2.4 GO:0008170 N-methyltransferase activity(GO:0008170)
0.0 0.8 GO:0044325 ion channel binding(GO:0044325)
0.0 0.8 GO:0017124 SH3 domain binding(GO:0017124)
0.0 3.4 GO:0003774 motor activity(GO:0003774)
0.0 0.1 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.8 PID ARF6 PATHWAY Arf6 signaling events
0.0 0.5 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.1 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.0 PID SHP2 PATHWAY SHP2 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.2 2.1 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.1 0.7 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.1 1.7 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.1 0.6 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 1.0 REACTOME FRS2 MEDIATED CASCADE Genes involved in FRS2-mediated cascade
0.0 0.5 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 1.2 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.4 REACTOME ION CHANNEL TRANSPORT Genes involved in Ion channel transport