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PRJEB1986: zebrafish developmental stages transcriptome

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Results for tfap2b

Z-value: 0.83

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Transcription factors associated with tfap2b

Gene Symbol Gene ID Gene Info
tfap2b
ENSDARG00000012667 transcription factor AP-2 beta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tfap2bdr11_v1_chr20_-_47704973_47704973-0.311.9e-01Click!

Activity profile of tfap2b motif

Sorted Z-values of tfap2b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_68563862 3.48 ENSDART00000182970
BX548011.2

chr15_-_20710 2.11 ENSDART00000161218
cyp2y3
cytochrome P450, family 2, subfamily Y, polypeptide 3
chr4_-_77563411 2.02 ENSDART00000186841
AL935186.8

chr4_-_77551860 1.99 ENSDART00000188176
AL935186.6

chr12_+_35119762 1.78 ENSDART00000085774
si:ch73-127m5.1
si:ch73-127m5.1
chr10_-_43964028 1.56 ENSDART00000009134
ENSDART00000133450
sept5b
septin 5b
chr14_-_51039702 1.38 ENSDART00000178932
cltb
clathrin, light chain B
chr24_+_37723362 1.35 ENSDART00000136836
rab11fip3
RAB11 family interacting protein 3 (class II)
chr22_-_17953529 1.33 ENSDART00000135716
ncanb
neurocan b
chr12_-_7807298 1.24 ENSDART00000191355
ank3b
ankyrin 3b
chr10_+_5135842 1.17 ENSDART00000132627
ENSDART00000162434
zgc:113274
zgc:113274
chr15_-_32131 1.09 ENSDART00000099074
ENSDART00000164323
CYP2C9
si:zfos-411a11.2
chr9_+_33783061 1.08 ENSDART00000190193
BX572627.1

chr12_-_21834611 1.07 ENSDART00000179553
thrab
thyroid hormone receptor alpha b
chr15_+_28318005 1.01 ENSDART00000175860
myo1cb
myosin Ic, paralog b
chr23_-_27701361 1.00 ENSDART00000186688
ENSDART00000183985
dnajc22
DnaJ (Hsp40) homolog, subfamily C, member 22
chr25_+_8063455 0.97 ENSDART00000073919
kcnc1b
potassium voltage-gated channel, Shaw-related subfamily, member 1b
chr23_-_1017605 0.93 ENSDART00000138290
cdh26.1
cadherin 26, tandem duplicate 1
chr2_-_34555945 0.91 ENSDART00000056671
brinp2
bone morphogenetic protein/retinoic acid inducible neural-specific 2
chr25_-_20870900 0.91 ENSDART00000171288
magi2b
membrane associated guanylate kinase, WW and PDZ domain containing 2b
chr7_+_1442059 0.90 ENSDART00000173391
si:cabz01090193.1
si:cabz01090193.1
chr19_+_41080240 0.89 ENSDART00000087295
ppp1r9a
protein phosphatase 1, regulatory subunit 9A
chr3_+_16455749 0.86 ENSDART00000090767
kcnj12b
potassium inwardly-rectifying channel, subfamily J, member 12b
chr19_+_25497541 0.77 ENSDART00000144300
col28a1a
collagen, type XXVIII, alpha 1a
chr6_+_7322587 0.76 ENSDART00000065500
abcc4
ATP-binding cassette, sub-family C (CFTR/MRP), member 4
chr18_+_9323211 0.75 ENSDART00000166114
sema3ab
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Ab
chr23_-_1017428 0.75 ENSDART00000110588
ENSDART00000183158
cdh26.1
cadherin 26, tandem duplicate 1
chr2_-_42415902 0.74 ENSDART00000142489
slco5a1b
solute carrier organic anion transporter family member 5A1b
chr18_+_40364732 0.72 ENSDART00000123661
ENSDART00000130847
sema6dl
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D, like
chr16_-_20435475 0.67 ENSDART00000139776
chn2
chimerin 2
chr20_-_47188966 0.64 ENSDART00000152965
si:dkeyp-104f11.9
si:dkeyp-104f11.9
chr24_-_38374744 0.64 ENSDART00000007208
lrrc4bb
leucine rich repeat containing 4Bb
chr2_+_39108339 0.61 ENSDART00000085675
clstn2
calsyntenin 2
chr2_-_31800521 0.60 ENSDART00000112763
retreg1
reticulophagy regulator 1
chr25_+_16945348 0.58 ENSDART00000016591
fgf6a
fibroblast growth factor 6a
chr7_+_19482084 0.58 ENSDART00000173873
si:ch211-212k18.7
si:ch211-212k18.7
chr8_-_47818282 0.57 ENSDART00000137149
kank3
KN motif and ankyrin repeat domains 3
chr11_-_35975026 0.55 ENSDART00000186219
itpr1b
inositol 1,4,5-trisphosphate receptor, type 1b
chr20_-_3160687 0.54 ENSDART00000131697
si:ch73-212j7.3
si:ch73-212j7.3
chr23_+_39461989 0.54 ENSDART00000184761
mical1
microtubule associated monooxygenase, calponin and LIM domain containing 1
chr7_-_38570878 0.52 ENSDART00000139187
ENSDART00000134570
ENSDART00000041055
celf1
cugbp, Elav-like family member 1
chr8_+_29963024 0.52 ENSDART00000149372
ptch1
patched 1
chr25_+_22017182 0.50 ENSDART00000156517
si:dkey-217l24.1
si:dkey-217l24.1
chr16_-_49846359 0.49 ENSDART00000184246
znf385d
zinc finger protein 385D
chr13_+_16521898 0.48 ENSDART00000122557
kcnma1a
potassium large conductance calcium-activated channel, subfamily M, alpha member 1a
chr24_+_42074143 0.47 ENSDART00000170514
top1mt
DNA topoisomerase I mitochondrial
chr6_+_38381957 0.46 ENSDART00000087300
gabrb3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr7_+_1521834 0.46 ENSDART00000174007
si:cabz01102082.1
si:cabz01102082.1
chr9_-_48864942 0.44 ENSDART00000113855
ENSDART00000189064
nostrin
nitric oxide synthase trafficking
chr25_+_21180695 0.44 ENSDART00000012923
erc1a
ELKS/RAB6-interacting/CAST family member 1a
chr4_+_37992753 0.42 ENSDART00000193890
CR759843.2

chr8_+_29962635 0.41 ENSDART00000007640
ptch1
patched 1
chr1_+_58990121 0.40 ENSDART00000171654
CABZ01083166.1

chr2_+_9918935 0.40 ENSDART00000140434
acbd5b
acyl-CoA binding domain containing 5b
chr5_+_7393346 0.39 ENSDART00000164238
si:ch73-72b7.1
si:ch73-72b7.1
chr9_+_44721808 0.38 ENSDART00000190578
nckap1
NCK-associated protein 1
chr10_+_6383270 0.37 ENSDART00000170548
zgc:114200
zgc:114200
chr21_-_27362938 0.36 ENSDART00000131297
rin1a
Ras and Rab interactor 1a
chr2_+_9918678 0.36 ENSDART00000081253
acbd5b
acyl-CoA binding domain containing 5b
chr21_+_21205667 0.36 ENSDART00000058311
rictorb
RPTOR independent companion of MTOR, complex 2b
chr7_-_38570299 0.34 ENSDART00000143815
celf1
cugbp, Elav-like family member 1
chr8_-_37056622 0.31 ENSDART00000111513
si:ch211-218o21.4
si:ch211-218o21.4
chr6_-_2171818 0.29 ENSDART00000181082
ENSDART00000187556
PXMP4
wu:fe02h09
chr6_-_19035749 0.27 ENSDART00000187714
sept9b
septin 9b
chr7_+_529522 0.27 ENSDART00000190811
nrxn2b
neurexin 2b
chr12_-_32013125 0.27 ENSDART00000153355
grin2cb
glutamate receptor, ionotropic, N-methyl D-aspartate 2Cb
chr11_-_37120954 0.27 ENSDART00000172074
NINJ1
si:ch1073-278o19.1
chr21_+_26748141 0.26 ENSDART00000169025
pcxa
pyruvate carboxylase a
chr16_-_21620947 0.25 ENSDART00000115011
ENSDART00000183125
ENSDART00000188856
ENSDART00000189460
ddr1
discoidin domain receptor tyrosine kinase 1
chr25_+_31264155 0.24 ENSDART00000012256
tnni2a.3
troponin I type 2a (skeletal, fast), tandem duplicate 3
chr17_-_29771639 0.24 ENSDART00000086201
ush2a
Usher syndrome 2A (autosomal recessive, mild)
chr10_-_5135788 0.23 ENSDART00000108587
ENSDART00000138537
sec31a
SEC31 homolog A, COPII coat complex component
chr25_+_23489979 0.22 ENSDART00000158200
CU024870.1

chr4_-_60790123 0.22 ENSDART00000137702
si:dkey-254e13.6
si:dkey-254e13.6
chr4_+_54439143 0.21 ENSDART00000170168
si:ch211-133h13.1
si:ch211-133h13.1
chr2_-_30324297 0.20 ENSDART00000099078
jph1b
junctophilin 1b
chr7_+_48667081 0.20 ENSDART00000083473
trpm5
transient receptor potential cation channel, subfamily M, member 5
chr15_-_45246911 0.17 ENSDART00000189557
ENSDART00000185291
CABZ01072607.1

chr1_+_32528097 0.14 ENSDART00000128317
nlgn4a
neuroligin 4a
chr17_-_26868169 0.13 ENSDART00000157204
si:dkey-221l4.10
si:dkey-221l4.10
chr6_+_9867426 0.13 ENSDART00000151749
MPP4 (1 of many)
si:ch211-222n4.6
chr25_+_6471401 0.10 ENSDART00000132927
snx33
sorting nexin 33
chr12_+_24562667 0.09 ENSDART00000056256
nrxn1a
neurexin 1a
chr14_+_11103718 0.09 ENSDART00000161311
nexmifb
neurite extension and migration factor b
chr4_+_58667348 0.08 ENSDART00000186596
ENSDART00000180673
CR388148.2

chr17_-_26867725 0.04 ENSDART00000153590
si:dkey-221l4.10
si:dkey-221l4.10
chr3_-_506241 0.02 ENSDART00000150141
si:dkey-12f6.5
si:dkey-12f6.5
chr10_-_14536399 0.01 ENSDART00000186501
hdhd2
haloacid dehalogenase-like hydrolase domain containing 2
chr6_-_7082108 0.00 ENSDART00000081760
ihhb
Indian hedgehog homolog b

Network of associatons between targets according to the STRING database.

First level regulatory network of tfap2b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0071470 cellular response to osmotic stress(GO:0071470)
0.2 0.9 GO:0061113 endodermal digestive tract morphogenesis(GO:0061031) pancreas morphogenesis(GO:0061113)
0.2 0.5 GO:0019417 sulfur oxidation(GO:0019417)
0.1 0.8 GO:0048755 branching morphogenesis of a nerve(GO:0048755)
0.1 1.1 GO:0002154 thyroid hormone mediated signaling pathway(GO:0002154)
0.1 0.9 GO:0048635 negative regulation of muscle organ development(GO:0048635)
0.1 0.9 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.1 0.4 GO:0072012 renal system vasculature development(GO:0061437) kidney vasculature development(GO:0061440) glomerulus vasculature development(GO:0072012)
0.1 0.6 GO:0061709 reticulophagy(GO:0061709)
0.1 0.7 GO:0010996 response to auditory stimulus(GO:0010996)
0.0 1.4 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.4 GO:0007220 Notch receptor processing(GO:0007220)
0.0 2.1 GO:0042737 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.0 0.4 GO:0048790 maintenance of presynaptic active zone structure(GO:0048790) maintenance of synapse structure(GO:0099558)
0.0 0.8 GO:0098754 detoxification(GO:0098754)
0.0 0.4 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.0 1.8 GO:0031638 zymogen activation(GO:0031638)
0.0 0.4 GO:0038203 TORC2 signaling(GO:0038203)
0.0 0.3 GO:0046958 nonassociative learning(GO:0046958) habituation(GO:0046959)
0.0 1.4 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.5 GO:0006265 DNA topological change(GO:0006265)
0.0 0.1 GO:0010812 negative regulation of cell-substrate adhesion(GO:0010812) negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.0 1.0 GO:0099515 vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.0 0.2 GO:0050909 sensory perception of taste(GO:0050909)
0.0 0.5 GO:0051209 release of sequestered calcium ion into cytosol(GO:0051209)
0.0 0.2 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.3 GO:0060079 excitatory postsynaptic potential(GO:0060079)
0.0 0.7 GO:0043113 receptor clustering(GO:0043113)
0.0 1.3 GO:0061640 cytoskeleton-dependent cytokinesis(GO:0061640)
0.0 0.7 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.0 0.2 GO:0031641 regulation of myelination(GO:0031641)
0.0 0.9 GO:1990573 potassium ion import across plasma membrane(GO:1990573)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 GO:0030132 trans-Golgi network transport vesicle membrane(GO:0012510) clathrin coat of trans-Golgi network vesicle(GO:0030130) clathrin coat of coated pit(GO:0030132)
0.1 0.4 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 2.1 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 0.2 GO:0043220 compact myelin(GO:0043218) Schmidt-Lanterman incisure(GO:0043220)
0.1 1.0 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 1.8 GO:0031105 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 0.4 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 0.2 GO:0030314 junctional membrane complex(GO:0030314)
0.0 1.7 GO:0016342 catenin complex(GO:0016342)
0.0 0.5 GO:0030667 secretory granule membrane(GO:0030667)
0.0 1.0 GO:0005902 microvillus(GO:0005902)
0.0 0.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.4 GO:0048788 cytoskeleton of presynaptic active zone(GO:0048788) presynaptic cytoskeleton(GO:0099569)
0.0 0.4 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.5 GO:1902711 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 0.2 GO:0030127 COPII vesicle coat(GO:0030127)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.2 0.9 GO:0097108 hedgehog family protein binding(GO:0097108)
0.2 0.9 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697) type II activin receptor binding(GO:0070699)
0.1 0.5 GO:0033149 FFAT motif binding(GO:0033149)
0.1 1.4 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 0.3 GO:0004736 pyruvate carboxylase activity(GO:0004736)
0.1 1.4 GO:0031267 small GTPase binding(GO:0031267)
0.1 1.4 GO:0015379 cation:chloride symporter activity(GO:0015377) potassium:chloride symporter activity(GO:0015379)
0.1 0.8 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.5 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.4 GO:0005042 netrin receptor activity(GO:0005042)
0.0 2.1 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.0 0.5 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.3 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062) collagen receptor activity(GO:0038064)
0.0 1.8 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.4 GO:0098882 structural constituent of presynaptic active zone(GO:0098882)
0.0 0.9 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 1.0 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.6 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 1.0 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 1.7 GO:0045296 cadherin binding(GO:0045296)
0.0 0.7 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.2 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.0 0.5 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 0.3 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 2.2 GO:0060090 binding, bridging(GO:0060090)
0.0 0.4 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.4 GO:0005540 hyaluronic acid binding(GO:0005540)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.1 1.4 PID ARF 3PATHWAY Arf1 pathway
0.0 0.9 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.7 PID RAC1 REG PATHWAY Regulation of RAC1 activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.4 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.0 0.5 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.8 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.9 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.2 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC