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PRJEB1986: zebrafish developmental stages transcriptome

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Results for tfap4

Z-value: 1.08

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Transcription factors associated with tfap4

Gene Symbol Gene ID Gene Info
ENSDARG00000103923 transcription factor AP-4 (activating enhancer binding protein 4)

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tfap4dr11_v1_chr3_-_12227359_122273590.087.5e-01Click!

Activity profile of tfap4 motif

Sorted Z-values of tfap4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_8360918 4.50 ENSDART00000004716
acid phosphatase 5a, tartrate resistant
chr20_-_29499363 3.08 ENSDART00000152889
ENSDART00000153252
ENSDART00000170972
ENSDART00000166420
ENSDART00000163079
ribonucleotide reductase M2 polypeptide
chr20_-_26420939 3.02 ENSDART00000110883
A kinase (PRKA) anchor protein 12b
chr20_-_26421112 3.00 ENSDART00000183767
ENSDART00000182330
A kinase (PRKA) anchor protein 12b
chr19_-_47571456 2.87 ENSDART00000158071
ENSDART00000165841
ribonucleotide reductase M2 polypeptide
chr3_-_21094437 2.85 ENSDART00000153739
ENSDART00000109790
nemo-like kinase, type 1
chr17_-_14836320 2.67 ENSDART00000157051
nidogen 2a (osteonidogen)
chr11_-_25384213 2.66 ENSDART00000103650
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Bb
chr7_+_39402864 2.55 ENSDART00000025852
troponin I type 2b (skeletal, fast), tandem duplicate 1
chr8_-_11229523 2.46 ENSDART00000002164
unc-45 myosin chaperone B
chr6_-_43092175 2.42 ENSDART00000084389
leucine rich repeat neuronal 1
chr12_+_6002715 2.40 ENSDART00000114961
si:ch211-131k2.3
chr14_-_32744464 2.31 ENSDART00000075617
SRY (sex determining region Y)-box 3
chr5_+_50879545 2.23 ENSDART00000128402
nucleolar protein 6 (RNA-associated)
chr3_-_19368435 2.12 ENSDART00000132987
sphingosine-1-phosphate receptor 5a
chr10_-_35257458 2.12 ENSDART00000143890
ENSDART00000139107
ENSDART00000082445
proline rich 11
chr2_-_21335131 2.05 ENSDART00000057022
kelch-like family member 40a
chr5_-_37341044 2.02 ENSDART00000084675
WD repeat domain 44
chr10_+_7593185 1.93 ENSDART00000162617
ENSDART00000162590
ENSDART00000171744
protein phosphatase 2, catalytic subunit, beta isozyme
chr23_-_27647769 1.86 ENSDART00000059974
wingless-type MMTV integration site family, member 10b
chr3_-_29962345 1.83 ENSDART00000136819
branched chain amino-acid transaminase 2, mitochondrial
chr2_+_11685742 1.81 ENSDART00000138562
growth regulation by estrogen in breast cancer-like
chr8_-_17184482 1.80 ENSDART00000025803
polymerase (DNA directed), alpha 2
chr13_+_43400443 1.79 ENSDART00000084321
dishevelled-binding antagonist of beta-catenin 2
chr3_+_34159192 1.77 ENSDART00000151119
coactivator-associated arginine methyltransferase 1
chr24_+_20575259 1.71 ENSDART00000010488
kelch-like family member 40b
chr6_+_59991076 1.70 ENSDART00000163575

chr5_+_25762271 1.69 ENSDART00000181323
transmembrane protein 2
chr9_-_27717006 1.67 ENSDART00000146860
general transcription factor IIE, polypeptide 1, alpha
chr23_-_19831739 1.66 ENSDART00000125066
HAUS augmin-like complex, subunit 7
chr2_-_17114852 1.65 ENSDART00000006549
PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae)
chr19_+_48102560 1.64 ENSDART00000164464
UTP18 small subunit (SSU) processome component
chr2_+_45081489 1.63 ENSDART00000123966
cholinergic receptor, nicotinic, gamma
chr11_+_37768298 1.62 ENSDART00000166886
SRY (sex determining region Y)-box 13
chr11_+_45448212 1.61 ENSDART00000173341
son of sevenless homolog 1 (Drosophila)
chr18_+_40381102 1.61 ENSDART00000136588
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D, like
chr3_-_29968015 1.58 ENSDART00000077119
ENSDART00000139310
branched chain amino-acid transaminase 2, mitochondrial
chr18_+_619619 1.57 ENSDART00000159846
protogenin homolog a (Gallus gallus)
chr9_+_21306902 1.57 ENSDART00000138554
ENSDART00000004108
exportin 4
chr24_+_39638555 1.57 ENSDART00000078313
LUC7-like (S. cerevisiae)
chr17_+_23975762 1.55 ENSDART00000155941
exportin 1 (CRM1 homolog, yeast) b
chr13_+_22295905 1.55 ENSDART00000180133
ENSDART00000181125
ubiquitin specific peptidase 54a
chr16_+_42772678 1.54 ENSDART00000155575
si:ch211-135n15.2
chr3_-_26978793 1.54 ENSDART00000155396
nucleotide binding protein 1 (MinD homolog, E. coli)
chr11_+_13642157 1.50 ENSDART00000060251
WD repeat domain 18
chr4_+_5832311 1.48 ENSDART00000121743
ENSDART00000158233
ENSDART00000165187
si:ch73-352p4.5
chr16_-_21903083 1.48 ENSDART00000165849
SET domain, bifurcated 1b
chr2_+_20866898 1.48 ENSDART00000150086
odr-4 GPCR localization factor homolog
chr2_-_23768818 1.46 ENSDART00000148685
ENSDART00000191167
xin actin binding repeat containing 1
chr22_+_21618121 1.44 ENSDART00000133939
transducin like enhancer of split 2a
chr14_-_22113600 1.43 ENSDART00000113752
si:dkey-6i22.5
chr1_+_49686408 1.42 ENSDART00000140824
si:ch211-149l1.2
chr13_+_40770628 1.41 ENSDART00000085846
NK1 transcription factor related 2-like,a
chr25_-_31423493 1.40 ENSDART00000027661
myogenic differentiation 1
chr25_+_19541019 1.39 ENSDART00000141056
ENSDART00000027740
neural precursor cell expressed, developmentally down-regulated 1
chr14_+_22113331 1.39 ENSDART00000109759
thioredoxin-related transmembrane protein 2a
chr11_-_22372072 1.39 ENSDART00000065996
transmembrane protein 183A
chr9_+_30633184 1.38 ENSDART00000191310
TBC1 domain family, member 4
chr22_-_26595027 1.35 ENSDART00000184162

chr7_+_66634167 1.34 ENSDART00000027616
eukaryotic translation initiation factor 4, gamma 2a
chr15_-_5624361 1.34 ENSDART00000176446
ENSDART00000114410
WD repeat domain 62
chr1_-_53277660 1.32 ENSDART00000014232
zinc finger protein 330
chr1_-_53277187 1.31 ENSDART00000131520
zinc finger protein 330
chr11_-_10456387 1.30 ENSDART00000011087
ENSDART00000081827
epithelial cell transforming 2
chr13_+_10024349 1.28 ENSDART00000138228
S1 RNA binding domain 1
chr15_+_7176182 1.27 ENSDART00000101578
hairy-related 8.2
chr18_-_44316920 1.27 ENSDART00000098599
si:ch211-151h10.2
chr7_+_41265618 1.26 ENSDART00000173688
scribbled planar cell polarity protein
chr18_-_19819812 1.26 ENSDART00000060344
alpha and gamma adaptin binding protein
chr5_-_1218801 1.22 ENSDART00000184398

chr21_+_5080789 1.22 ENSDART00000024199
ATP synthase F1 subunit alpha
chr14_+_38656776 1.21 ENSDART00000186197
ENSDART00000185861
ENSDART00000020625
F-box protein 38
chr3_+_29640837 1.21 ENSDART00000132298
eukaryotic translation initiation factor 3, subunit D
chr11_+_3246059 1.21 ENSDART00000161529
timeless circadian clock
chr25_-_36492779 1.20 ENSDART00000042271
iroquois homeobox 3b
chr3_+_39663987 1.20 ENSDART00000184614
ENSDART00000184573
ENSDART00000183127
epsin 2
chr19_-_10214264 1.20 ENSDART00000053300
ENSDART00000148225
zinc finger protein 865
chr22_-_18241390 1.19 ENSDART00000083879
transmembrane protein 161A
chr8_-_15211164 1.18 ENSDART00000110550
BCAR3, NSP family adaptor protein
chr20_+_30378803 1.18 ENSDART00000148242
ENSDART00000169140
ENSDART00000062441
ribonuclease H1
chr17_+_23964132 1.16 ENSDART00000154823
exportin 1 (CRM1 homolog, yeast) b
chr20_-_42439896 1.16 ENSDART00000061049
vestigial-like family member 2a
chr1_-_53277413 1.16 ENSDART00000150579
zinc finger protein 330
chr12_-_33579873 1.15 ENSDART00000184661
tudor and KH domain containing
chr20_+_25904199 1.14 ENSDART00000016864
solute carrier family 35, member F6
chr5_-_11809404 1.14 ENSDART00000132564
neurofibromin 2a (merlin)
chr11_-_21528056 1.14 ENSDART00000181626
SLIT-ROBO Rho GTPase activating protein 2
chr3_-_29977495 1.14 ENSDART00000077111
hydroxysteroid (17-beta) dehydrogenase 14
chr23_+_44461493 1.13 ENSDART00000149854
si:ch1073-228j22.1
chr2_+_23790748 1.12 ENSDART00000041877
cysteine-serine-rich nuclear protein 1a
chr20_+_28364742 1.12 ENSDART00000103355
ras homolog family member V
chr3_+_29640996 1.10 ENSDART00000011052
eukaryotic translation initiation factor 3, subunit D
chr19_+_4968947 1.10 ENSDART00000003634
ENSDART00000134808
StAR-related lipid transfer (START) domain containing 3
chr17_+_23968214 1.09 ENSDART00000183053
exportin 1 (CRM1 homolog, yeast) b
chr2_+_32016516 1.08 ENSDART00000135040
MYC proto-oncogene, bHLH transcription factor b
chr21_-_21515466 1.08 ENSDART00000147593
nectin cell adhesion molecule 3b
chr3_-_35865040 1.07 ENSDART00000102952
SUZ12 polycomb repressive complex 2a subunit
chr21_-_45882643 1.06 ENSDART00000168703
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)
chr10_+_31809226 1.06 ENSDART00000087898
forkhead box O1 b
chr23_+_16935494 1.06 ENSDART00000143120
si:dkey-147f3.4
chr22_-_24984733 1.06 ENSDART00000142147
ENSDART00000187284
dynein, axonemal, light chain 4b
chr2_-_15040345 1.06 ENSDART00000109657
si:dkey-10f21.4
chr3_+_17910569 1.05 ENSDART00000080946
tetratricopeptide repeat domain 25
chr11_-_11792766 1.05 ENSDART00000011657
cell division cycle 6 homolog (S. cerevisiae)
chr8_-_50981175 1.05 ENSDART00000004065
zgc:91909
chr2_+_36620011 1.04 ENSDART00000177428
p21 protein (Cdc42/Rac)-activated kinase 2a
chr2_-_39015130 1.04 ENSDART00000044331
coatomer protein complex, subunit beta 2
chr8_+_23382568 1.04 ENSDART00000129167
microtubule-associated protein, RP/EB family, member 1a
chr11_+_6136220 1.04 ENSDART00000082223
Tax1 (human T-cell leukemia virus type I) binding protein 3
chr11_-_3533356 1.03 ENSDART00000161972
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 19 (DBP5 homolog, yeast)
chr11_+_30744266 1.03 ENSDART00000132491
ENSDART00000103273
WD repeat domain 83 opposite strand
chr4_+_18707174 1.03 ENSDART00000142343
wingless-type MMTV integration site family, member 7Ba
chr19_+_29808699 1.03 ENSDART00000051799
ENSDART00000164205
histone deacetylase 1
chr8_+_52701811 1.02 ENSDART00000179692
BCL2 like 16
chr15_-_39969988 1.02 ENSDART00000146054
ribosomal protein S5
chr20_+_20484827 1.01 ENSDART00000048110
SIX homeobox 4b
chr21_+_28747069 1.01 ENSDART00000014058
zgc:100829
chr5_-_65121747 1.01 ENSDART00000165556
torsin family 2, member A
chr20_+_43691208 1.01 ENSDART00000152976
ENSDART00000045185
lin-9 DREAM MuvB core complex component
chr21_+_30351256 1.01 ENSDART00000078341
forkhead box I3a
chr6_+_32046202 1.00 ENSDART00000156552
si:dkey-148h10.5
chr6_+_16031189 0.99 ENSDART00000015333
gastrulation brain homeobox 2
chr6_-_10728057 0.99 ENSDART00000002247
Sp3b transcription factor
chr8_+_29749017 0.99 ENSDART00000185144
mitogen-activated protein kinase 4
chr15_+_40188076 0.99 ENSDART00000063779
EF-hand domain family, member D1
chr12_+_33894665 0.99 ENSDART00000004769
major facilitator superfamily domain containing 13A
chr11_-_14789918 0.98 ENSDART00000179670
small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
chr6_-_10728921 0.98 ENSDART00000151484
Sp3b transcription factor
chr19_-_42503143 0.97 ENSDART00000007642
zgc:110239
chr6_-_33924883 0.96 ENSDART00000132762
ENSDART00000148142
ENSDART00000142213
aldo-keto reductase family 1, member A1b (aldehyde reductase)
chr5_-_41531629 0.96 ENSDART00000051082
aldo-keto reductase family 1, member A1a (aldehyde reductase)
chr19_-_2318391 0.95 ENSDART00000012791
sp8 transcription factor a
chr13_+_21826096 0.94 ENSDART00000056432
zinc finger, SWIM-type containing 8
chr7_+_38809241 0.94 ENSDART00000190979
harbinger transposase derived 1
chr2_-_20866758 0.93 ENSDART00000165374
translocated promoter region a, nuclear basket protein
chr1_+_49352900 0.93 ENSDART00000008468
muscle segment homeobox 1b
chr5_+_15819651 0.92 ENSDART00000081230
ENSDART00000186969
ENSDART00000134206
heat shock protein b8
chr11_-_18705303 0.92 ENSDART00000059732
inhibitor of DNA binding 1
chr2_-_17115256 0.91 ENSDART00000190488
PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae)
chr23_+_37815645 0.91 ENSDART00000011627
iroquois homeobox 7
chr6_+_33076839 0.91 ENSDART00000073755
ENSDART00000122242
protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)
chr5_+_45007962 0.91 ENSDART00000010786
doublesex and mab-3 related transcription factor 2a
chr2_+_4208323 0.89 ENSDART00000167906
GATA binding protein 6
chr23_+_35714574 0.89 ENSDART00000164616
tubulin, alpha 1c
chr5_+_65970235 0.88 ENSDART00000166432
solute carrier family 2 (facilitated glucose transporter), member 8
chr7_-_28565230 0.88 ENSDART00000028887
TMEM9 domain family, member B
chr6_-_37460178 0.88 ENSDART00000153500
si:dkey-66a8.7
chr7_-_26049282 0.88 ENSDART00000136389
ENSDART00000101124
ribonuclease, RNase K a
chr10_+_35257651 0.88 ENSDART00000028940
serine/threonine/tyrosine interacting-like 1
chr20_-_36887516 0.88 ENSDART00000076313
taxilin beta a
chr15_-_16177603 0.87 ENSDART00000156352
si:ch211-259g3.4
chr5_+_31779911 0.87 ENSDART00000098163
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25b
chr17_-_45386546 0.87 ENSDART00000182647
transmembrane protein 206
chr5_+_34622320 0.87 ENSDART00000141338
ectodermal-neural cortex 1
chr24_-_9300160 0.87 ENSDART00000152378
TGFB-induced factor homeobox 1
chr9_+_41821613 0.87 ENSDART00000097295
collagen type XVIII alpha 1 chain a
chr17_+_8799451 0.87 ENSDART00000189814
ENSDART00000191577
tonsoku-like, DNA repair protein
chr2_+_24700922 0.86 ENSDART00000170467
phosphoinositide-3-kinase, regulatory subunit 2 (beta)
chr20_-_36887176 0.86 ENSDART00000143515
ENSDART00000146994
taxilin beta a
chr22_-_22231720 0.86 ENSDART00000160165
adaptor-related protein complex 3, delta 1 subunit
chr6_-_33925381 0.85 ENSDART00000137268
ENSDART00000145019
ENSDART00000141822
aldo-keto reductase family 1, member A1b (aldehyde reductase)
chr7_-_23745984 0.85 ENSDART00000048050
zgc:92429
chr2_-_11027258 0.85 ENSDART00000081072
ENSDART00000193824
ENSDART00000187036
ENSDART00000097741
single stranded DNA binding protein 3a
chr9_-_53666031 0.84 ENSDART00000126314
protocadherin 8
chr4_+_8016457 0.84 ENSDART00000014036
optineurin
chr23_-_21215520 0.84 ENSDART00000143206
multiple EGF-like-domains 6a
chr19_+_10661520 0.84 ENSDART00000091813
ENSDART00000165653
argonaute RISC catalytic component 3b
chr9_+_3519191 0.83 ENSDART00000008606
methyltransferase like 8
chr21_+_19334198 0.82 ENSDART00000147372
helicase, POLQ like
chr19_+_29808471 0.82 ENSDART00000186428
histone deacetylase 1
chr14_-_32016615 0.82 ENSDART00000105761
zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)
chr11_+_13423776 0.81 ENSDART00000102553
homer scaffolding protein 3b
chr17_-_45386823 0.80 ENSDART00000156002
transmembrane protein 206
chr22_+_465269 0.80 ENSDART00000145767
cadherin, EGF LAG seven-pass G-type receptor 2
chr17_+_8799661 0.80 ENSDART00000105326
tonsoku-like, DNA repair protein
chr15_+_29088426 0.79 ENSDART00000187290
si:ch211-137a8.4
chr19_-_27336092 0.77 ENSDART00000176885
general transcription factor IIH, polypeptide 4
chr1_-_39895859 0.77 ENSDART00000135791
ENSDART00000035739
transmembrane protein 134
chr12_+_4920451 0.77 ENSDART00000171525
ENSDART00000159986
pleckstrin homology domain containing, family M (with RUN domain) member 1
chr20_+_54280549 0.76 ENSDART00000151048
ARP10 actin related protein 10 homolog
chr16_+_46684855 0.76 ENSDART00000058325
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
chr18_-_7448047 0.76 ENSDART00000193213
ENSDART00000131940
ENSDART00000186944
ENSDART00000052803
si:dkey-30c15.10
chr4_-_78026285 0.76 ENSDART00000168273
chaperonin containing TCP1 subunit 2
chr3_-_40836081 0.75 ENSDART00000143135
WD repeat domain, phosphoinositide interacting 2
chr12_+_27127139 0.75 ENSDART00000025966
homeobox B6b
chr8_+_25145464 0.75 ENSDART00000136505
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
chr25_+_17871089 0.75 ENSDART00000133725
BTB (POZ) domain containing 10a
chr15_+_24676905 0.75 ENSDART00000078014
ENSDART00000143137
polymerase (DNA-directed), delta interacting protein 2
chr10_-_8294965 0.74 ENSDART00000167380
phospholipid phosphatase 1a
chr15_+_9861973 0.74 ENSDART00000170945
si:dkey-13m3.2
chr5_+_30392148 0.74 ENSDART00000086765
serine/threonine kinase 36 (fused homolog, Drosophila)
chr25_+_19666621 0.73 ENSDART00000112746
zgc:171459
chr5_-_68333081 0.72 ENSDART00000168786
linker histone H1M
chr7_+_44715224 0.72 ENSDART00000184630
si:dkey-56m19.5
chr8_-_14609284 0.72 ENSDART00000146175
centrosomal protein 350
chr7_-_24364536 0.72 ENSDART00000064789
thioredoxin
chr14_+_46342882 0.71 ENSDART00000193707
ENSDART00000060577
transmembrane protein 33
chr5_+_2002804 0.71 ENSDART00000064088
vitamin K epoxide reductase complex, subunit 1-like 1
chr23_-_21215311 0.71 ENSDART00000112424
multiple EGF-like-domains 6a
chr19_+_14454306 0.70 ENSDART00000161965
zinc finger, DHHC-type containing 18b

Network of associatons between targets according to the STRING database.

First level regulatory network of tfap4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.3 GO:0032060 bleb assembly(GO:0032060) slow muscle cell migration(GO:1904969)
1.3 3.8 GO:0098528 skeletal muscle fiber differentiation(GO:0098528)
0.9 3.4 GO:0009098 leucine biosynthetic process(GO:0009098)
0.8 2.3 GO:0002191 cap-dependent translational initiation(GO:0002191)
0.7 2.2 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.6 1.7 GO:0001112 DNA-templated transcriptional open complex formation(GO:0001112) transcriptional open complex formation at RNA polymerase II promoter(GO:0001113) protein-DNA complex remodeling(GO:0001120)
0.5 6.0 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.5 1.4 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.4 1.8 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.4 3.8 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.4 4.5 GO:0045453 bone resorption(GO:0045453)
0.4 1.1 GO:0071896 protein localization to adherens junction(GO:0071896)
0.4 1.8 GO:0006011 UDP-glucose metabolic process(GO:0006011)
0.4 2.1 GO:1902946 protein localization to early endosome(GO:1902946)
0.3 1.0 GO:2000008 regulation of protein localization to cell surface(GO:2000008) negative regulation of protein localization to cell surface(GO:2000009)
0.3 1.4 GO:0070987 error-free translesion synthesis(GO:0070987)
0.3 1.0 GO:1903646 regulation of protein folding(GO:1903332) positive regulation of protein folding(GO:1903334) regulation of chaperone-mediated protein folding(GO:1903644) positive regulation of chaperone-mediated protein folding(GO:1903646)
0.3 2.4 GO:0021628 olfactory nerve development(GO:0021553) olfactory nerve morphogenesis(GO:0021627) olfactory nerve formation(GO:0021628)
0.3 1.8 GO:1900108 negative regulation of nodal signaling pathway(GO:1900108)
0.3 1.8 GO:0033687 osteoblast proliferation(GO:0033687)
0.3 1.0 GO:0009957 epidermal cell fate specification(GO:0009957)
0.2 1.2 GO:0043111 replication fork arrest(GO:0043111)
0.2 0.7 GO:0042373 vitamin K metabolic process(GO:0042373)
0.2 1.2 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.2 0.7 GO:0043416 regulation of skeletal muscle tissue regeneration(GO:0043416)
0.2 1.1 GO:2001223 negative regulation of neuron migration(GO:2001223)
0.2 0.9 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway(GO:2001244)
0.2 2.6 GO:0000002 mitochondrial genome maintenance(GO:0000002)
0.2 0.8 GO:0090161 Golgi ribbon formation(GO:0090161)
0.2 0.6 GO:1903373 regulation of endoplasmic reticulum tubular network organization(GO:1903371) positive regulation of endoplasmic reticulum tubular network organization(GO:1903373)
0.2 0.7 GO:0060307 regulation of membrane repolarization(GO:0060306) regulation of ventricular cardiac muscle cell membrane repolarization(GO:0060307) regulation of cardiac muscle cell membrane repolarization(GO:0099623) ventricular cardiac muscle cell membrane repolarization(GO:0099625)
0.2 0.9 GO:0001773 myeloid dendritic cell activation(GO:0001773) myeloid dendritic cell differentiation(GO:0043011)
0.2 1.1 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.2 2.1 GO:0044837 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
0.2 1.7 GO:0072091 regulation of stem cell proliferation(GO:0072091)
0.2 1.0 GO:0031055 chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.2 0.7 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.2 2.4 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.2 0.6 GO:1900136 regulation of cytokine activity(GO:0060300) regulation of receptor binding(GO:1900120) regulation of chemokine activity(GO:1900136)
0.2 1.4 GO:0071539 protein localization to centrosome(GO:0071539)
0.2 0.8 GO:0032289 central nervous system myelin formation(GO:0032289)
0.2 1.2 GO:0035777 pronephric distal tubule development(GO:0035777)
0.1 1.5 GO:0071479 cellular response to ionizing radiation(GO:0071479)
0.1 1.6 GO:0006611 protein export from nucleus(GO:0006611)
0.1 0.6 GO:0035553 oxidative single-stranded RNA demethylation(GO:0035553)
0.1 0.7 GO:1990592 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.1 0.9 GO:1901673 regulation of mitotic spindle assembly(GO:1901673)
0.1 1.1 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.1 0.7 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.1 0.5 GO:0021742 abducens nucleus development(GO:0021742)
0.1 0.9 GO:0016266 O-glycan processing(GO:0016266)
0.1 0.4 GO:0070126 mitochondrial translational termination(GO:0070126)
0.1 1.1 GO:0097345 mitochondrial outer membrane permeabilization(GO:0097345)
0.1 1.5 GO:0090329 regulation of DNA-dependent DNA replication(GO:0090329)
0.1 1.0 GO:0021871 forebrain regionalization(GO:0021871)
0.1 0.6 GO:0010456 cell proliferation in dorsal spinal cord(GO:0010456)
0.1 0.4 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.1 1.4 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.1 0.3 GO:0015808 L-alanine transport(GO:0015808) proline transport(GO:0015824)
0.1 1.5 GO:0090308 methylation-dependent chromatin silencing(GO:0006346) positive regulation of chromatin silencing(GO:0031937) regulation of methylation-dependent chromatin silencing(GO:0090308) positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.1 2.6 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.1 0.6 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
0.1 0.5 GO:0043476 pigment accumulation(GO:0043476)
0.1 0.7 GO:0035881 amacrine cell differentiation(GO:0035881)
0.1 0.9 GO:0099514 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.1 1.7 GO:0031297 replication fork processing(GO:0031297)
0.1 0.6 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.1 3.2 GO:0043049 otic placode formation(GO:0043049)
0.1 0.4 GO:0010828 positive regulation of glucose transport(GO:0010828)
0.1 0.5 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.1 0.3 GO:0036228 protein targeting to nuclear inner membrane(GO:0036228) protein localization to nuclear envelope(GO:0090435)
0.1 1.4 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.1 0.9 GO:0072498 embryonic skeletal joint development(GO:0072498)
0.1 0.7 GO:0018904 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.1 0.8 GO:0021754 facial nucleus development(GO:0021754)
0.1 0.7 GO:1901339 regulation of store-operated calcium channel activity(GO:1901339)
0.1 0.5 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.1 0.3 GO:0044650 virion attachment to host cell(GO:0019062) adhesion of symbiont to host(GO:0044406) adhesion of symbiont to host cell(GO:0044650)
0.1 2.9 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.1 1.6 GO:0007271 synaptic transmission, cholinergic(GO:0007271)
0.1 0.5 GO:0006620 posttranslational protein targeting to membrane(GO:0006620) posttranslational protein targeting to membrane, translocation(GO:0031204)
0.1 0.5 GO:0044783 G1 DNA damage checkpoint(GO:0044783)
0.1 0.2 GO:1903060 N-terminal protein palmitoylation(GO:0006500) negative regulation of lipoprotein metabolic process(GO:0050748) regulation of N-terminal protein palmitoylation(GO:0060254) negative regulation of N-terminal protein palmitoylation(GO:0060262) negative regulation of protein lipidation(GO:1903060)
0.1 0.7 GO:0006465 signal peptide processing(GO:0006465)
0.1 1.0 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.1 0.4 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.1 0.5 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.1 0.5 GO:0046487 glyoxylate metabolic process(GO:0046487)
0.1 0.3 GO:0002762 negative regulation of myeloid leukocyte differentiation(GO:0002762)
0.1 1.5 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.1 1.8 GO:0006270 DNA replication initiation(GO:0006270)
0.1 0.2 GO:0009972 cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
0.1 0.3 GO:0072103 renal system vasculature morphogenesis(GO:0061438) kidney vasculature morphogenesis(GO:0061439) glomerulus vasculature morphogenesis(GO:0072103) glomerular capillary formation(GO:0072104)
0.1 0.7 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.1 0.5 GO:0033278 cell proliferation in midbrain(GO:0033278)
0.1 0.9 GO:0043550 regulation of lipid kinase activity(GO:0043550) regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.1 0.2 GO:0045724 positive regulation of cilium assembly(GO:0045724)
0.1 0.5 GO:0007020 microtubule nucleation(GO:0007020)
0.1 0.3 GO:0090646 mitochondrial tRNA processing(GO:0090646)
0.1 2.5 GO:0007050 cell cycle arrest(GO:0007050)
0.1 1.0 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.1 0.3 GO:0006004 fucose metabolic process(GO:0006004)
0.1 2.1 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.1 0.2 GO:0045922 negative regulation of fatty acid metabolic process(GO:0045922)
0.1 1.2 GO:0033138 positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.1 1.2 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 0.1 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.1 0.5 GO:0046627 negative regulation of insulin receptor signaling pathway(GO:0046627) negative regulation of cellular response to insulin stimulus(GO:1900077)
0.0 1.5 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.5 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.4 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.0 2.5 GO:0003009 skeletal muscle contraction(GO:0003009)
0.0 0.3 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 1.2 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.2 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.0 0.2 GO:0032530 regulation of microvillus organization(GO:0032530) regulation of microvillus assembly(GO:0032534)
0.0 0.5 GO:0003139 secondary heart field specification(GO:0003139)
0.0 0.4 GO:0003422 growth plate cartilage morphogenesis(GO:0003422) chondrocyte intercalation involved in growth plate cartilage morphogenesis(GO:0003428)
0.0 1.6 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.6 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.5 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 0.2 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
0.0 0.9 GO:1902667 regulation of axon guidance(GO:1902667)
0.0 0.7 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.5 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 0.4 GO:0021702 cerebellar granular layer development(GO:0021681) cerebellar granular layer morphogenesis(GO:0021683) cerebellar granular layer formation(GO:0021684) cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702) cerebellar granule cell differentiation(GO:0021707)
0.0 2.6 GO:0051225 spindle assembly(GO:0051225)
0.0 1.5 GO:0061386 closure of optic fissure(GO:0061386)
0.0 0.7 GO:0034453 microtubule anchoring(GO:0034453)
0.0 0.4 GO:1904263 positive regulation of TORC1 signaling(GO:1904263)
0.0 1.1 GO:0007286 spermatid development(GO:0007286)
0.0 1.9 GO:0030917 midbrain-hindbrain boundary development(GO:0030917)
0.0 3.9 GO:0050768 negative regulation of neurogenesis(GO:0050768)
0.0 0.3 GO:0035188 hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.0 0.3 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.2 GO:1901841 regulation of high voltage-gated calcium channel activity(GO:1901841) negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.0 0.1 GO:0046168 NADH oxidation(GO:0006116) glycerol-3-phosphate catabolic process(GO:0046168)
0.0 0.1 GO:0035988 chondrocyte proliferation(GO:0035988)
0.0 0.3 GO:0031268 pseudopodium organization(GO:0031268) pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.0 0.1 GO:0033212 iron assimilation(GO:0033212)
0.0 0.4 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.0 0.5 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 2.0 GO:0090090 negative regulation of canonical Wnt signaling pathway(GO:0090090)
0.0 0.3 GO:0044804 nucleophagy(GO:0044804)
0.0 0.8 GO:0060972 left/right pattern formation(GO:0060972)
0.0 0.4 GO:0032264 IMP salvage(GO:0032264)
0.0 0.9 GO:0007548 sex differentiation(GO:0007548)
0.0 0.4 GO:0035269 protein O-linked mannosylation(GO:0035269) ER-associated misfolded protein catabolic process(GO:0071712)
0.0 0.4 GO:0060285 cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285)
0.0 0.2 GO:0090497 skin morphogenesis(GO:0043589) mesenchymal cell migration(GO:0090497)
0.0 0.5 GO:0031167 rRNA methylation(GO:0031167)
0.0 0.2 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 0.1 GO:1900028 wound healing, spreading of epidermal cells(GO:0035313) negative regulation of ruffle assembly(GO:1900028)
0.0 0.2 GO:0045646 regulation of erythrocyte differentiation(GO:0045646)
0.0 0.4 GO:0048936 peripheral nervous system neuron axonogenesis(GO:0048936)
0.0 0.3 GO:0044154 histone H3-K14 acetylation(GO:0044154)
0.0 0.2 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.0 0.4 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 0.2 GO:0006777 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.0 0.9 GO:0034620 cellular response to unfolded protein(GO:0034620)
0.0 1.5 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 0.5 GO:0014029 neural crest formation(GO:0014029)
0.0 0.3 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.0 0.5 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.0 1.0 GO:0060389 pathway-restricted SMAD protein phosphorylation(GO:0060389)
0.0 0.3 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 1.1 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.7 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.1 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 0.1 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.0 0.7 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.2 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.3 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.0 0.1 GO:0031063 regulation of histone deacetylation(GO:0031063)
0.0 1.3 GO:0007498 mesoderm development(GO:0007498)
0.0 0.0 GO:0001954 positive regulation of cell-matrix adhesion(GO:0001954)
0.0 0.4 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)
0.0 0.7 GO:0035082 axoneme assembly(GO:0035082)
0.0 2.6 GO:0045165 cell fate commitment(GO:0045165)
0.0 0.4 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.4 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 0.1 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.0 0.2 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.0 0.6 GO:0034111 negative regulation of homotypic cell-cell adhesion(GO:0034111) negative regulation of T cell activation(GO:0050868) negative regulation of leukocyte cell-cell adhesion(GO:1903038)
0.0 0.4 GO:0003351 epithelial cilium movement(GO:0003351)
0.0 0.6 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 1.5 GO:0021782 glial cell development(GO:0021782)
0.0 1.5 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.3 GO:0008272 sulfate transport(GO:0008272)
0.0 0.3 GO:0032924 activin receptor signaling pathway(GO:0032924)
0.0 0.8 GO:0007030 Golgi organization(GO:0007030)
0.0 0.1 GO:1902624 positive regulation of neutrophil migration(GO:1902624)
0.0 1.2 GO:0048703 embryonic viscerocranium morphogenesis(GO:0048703)
0.0 0.1 GO:0071910 determination of liver left/right asymmetry(GO:0071910)
0.0 0.7 GO:0001755 neural crest cell migration(GO:0001755)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.2 GO:0034456 CURI complex(GO:0032545) UTP-C complex(GO:0034456)
0.4 1.8 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.4 1.4 GO:0000818 nuclear MIS12/MIND complex(GO:0000818)
0.3 1.7 GO:0005673 transcription factor TFIIE complex(GO:0005673)
0.3 1.0 GO:0072380 TRC complex(GO:0072380)
0.2 1.2 GO:0031298 replication fork protection complex(GO:0031298)
0.2 1.7 GO:0005662 DNA replication factor A complex(GO:0005662)
0.2 1.6 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.2 0.7 GO:0005828 kinetochore microtubule(GO:0005828)
0.2 0.7 GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.2 6.2 GO:0031672 A band(GO:0031672)
0.2 0.6 GO:0098826 endoplasmic reticulum tubular network membrane(GO:0098826)
0.2 0.6 GO:0033268 node of Ranvier(GO:0033268)
0.2 1.7 GO:0070652 HAUS complex(GO:0070652)
0.2 1.4 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.2 1.2 GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.2 0.7 GO:0005787 signal peptidase complex(GO:0005787)
0.1 1.1 GO:0044232 organelle membrane contact site(GO:0044232)
0.1 1.6 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 0.6 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.1 0.8 GO:0000439 core TFIIH complex(GO:0000439)
0.1 0.7 GO:0071986 Ragulator complex(GO:0071986)
0.1 0.8 GO:0005826 actomyosin contractile ring(GO:0005826)
0.1 2.3 GO:0016282 eukaryotic 43S preinitiation complex(GO:0016282)
0.1 0.8 GO:0031332 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.1 1.2 GO:0030126 COPI vesicle coat(GO:0030126)
0.1 0.7 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 1.2 GO:0030669 clathrin coat of endocytic vesicle(GO:0030128) clathrin-coated endocytic vesicle membrane(GO:0030669)
0.1 0.3 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.1 1.8 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 0.3 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.1 0.6 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.1 0.5 GO:0030897 HOPS complex(GO:0030897)
0.1 1.1 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 0.5 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.1 0.2 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.1 0.4 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.1 0.3 GO:0044611 nuclear pore inner ring(GO:0044611)
0.1 2.6 GO:0005657 replication fork(GO:0005657)
0.1 1.6 GO:0005685 U1 snRNP(GO:0005685)
0.1 0.6 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024) nuclear cyclin-dependent protein kinase holoenzyme complex(GO:0019908)
0.1 0.9 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.1 0.8 GO:0002102 podosome(GO:0002102)
0.1 2.5 GO:0005861 troponin complex(GO:0005861)
0.1 1.1 GO:0044327 dendritic spine head(GO:0044327)
0.0 0.8 GO:0005869 dynactin complex(GO:0005869)
0.0 0.4 GO:0032797 SMN complex(GO:0032797)
0.0 0.2 GO:0070743 interleukin-12 complex(GO:0043514) interleukin-23 complex(GO:0070743)
0.0 0.4 GO:0005682 U5 snRNP(GO:0005682)
0.0 2.5 GO:0005643 nuclear pore(GO:0005643)
0.0 0.1 GO:1990745 EARP complex(GO:1990745)
0.0 0.2 GO:0033557 Slx1-Slx4 complex(GO:0033557)
0.0 0.9 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 0.6 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.0 0.2 GO:0019008 molybdopterin synthase complex(GO:0019008)
0.0 0.1 GO:1990072 TRAPPIII protein complex(GO:1990072)
0.0 0.3 GO:0000153 cytoplasmic ubiquitin ligase complex(GO:0000153)
0.0 1.0 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.6 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 5.7 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 1.6 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 3.6 GO:0016324 apical plasma membrane(GO:0016324)
0.0 2.7 GO:0005604 basement membrane(GO:0005604)
0.0 1.0 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 3.9 GO:0032993 protein-DNA complex(GO:0032993)
0.0 1.9 GO:0005814 centriole(GO:0005814)
0.0 0.5 GO:1990391 DNA repair complex(GO:1990391)
0.0 0.1 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0 1.7 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.3 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0 1.2 GO:0030286 dynein complex(GO:0030286)
0.0 0.3 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.4 GO:0045180 basal cortex(GO:0045180)
0.0 0.4 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.4 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.3 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.4 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.3 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.8 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 4.2 GO:0005730 nucleolus(GO:0005730)
0.0 0.3 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.5 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 1.0 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.8 GO:0030173 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.0 0.8 GO:0005581 collagen trimer(GO:0005581)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.4 GO:0052656 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.9 6.0 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.8 2.3 GO:0098808 mRNA cap binding(GO:0098808)
0.6 4.5 GO:0003993 acid phosphatase activity(GO:0003993)
0.6 2.8 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.5 5.4 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.5 2.6 GO:0043139 5'-3' DNA helicase activity(GO:0043139)
0.4 1.3 GO:0000810 diacylglycerol diphosphate phosphatase activity(GO:0000810)
0.4 1.8 GO:0003983 UTP:glucose-1-phosphate uridylyltransferase activity(GO:0003983) UTP-monosaccharide-1-phosphate uridylyltransferase activity(GO:0051748)
0.4 5.3 GO:0051879 Hsp90 protein binding(GO:0051879)
0.4 1.8 GO:0008469 histone-arginine N-methyltransferase activity(GO:0008469)
0.3 1.2 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.3 2.1 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.2 0.7 GO:0071568 UFM1 transferase activity(GO:0071568)
0.2 0.6 GO:0031701 angiotensin receptor binding(GO:0031701)
0.2 0.8 GO:0016427 tRNA (cytosine) methyltransferase activity(GO:0016427)
0.2 1.4 GO:0070888 E-box binding(GO:0070888)
0.2 6.6 GO:0051018 protein kinase A binding(GO:0051018)
0.2 1.2 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.2 1.5 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.2 0.7 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.2 0.6 GO:0035575 histone demethylase activity (H4-K20 specific)(GO:0035575)
0.2 0.6 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.1 0.6 GO:1990931 RNA N6-methyladenosine dioxygenase activity(GO:1990931)
0.1 0.6 GO:0008430 selenium binding(GO:0008430)
0.1 3.8 GO:0004707 MAP kinase activity(GO:0004707)
0.1 0.5 GO:0070412 R-SMAD binding(GO:0070412)
0.1 0.3 GO:0004394 heparan sulfate 2-O-sulfotransferase activity(GO:0004394)
0.1 0.3 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 0.5 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.1 0.3 GO:0070513 death domain binding(GO:0070513)
0.1 0.3 GO:0019777 Atg12 transferase activity(GO:0019777)
0.1 0.8 GO:0035198 miRNA binding(GO:0035198)
0.1 1.7 GO:0051011 microtubule minus-end binding(GO:0051011)
0.1 0.7 GO:0043515 kinetochore binding(GO:0043515)
0.1 0.3 GO:0004649 poly(ADP-ribose) glycohydrolase activity(GO:0004649)
0.1 0.5 GO:0008312 7S RNA binding(GO:0008312)
0.1 0.3 GO:0052905 tRNA (guanine(9)-N(1))-methyltransferase activity(GO:0052905)
0.1 1.4 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 0.3 GO:0015180 L-alanine transmembrane transporter activity(GO:0015180) L-proline transmembrane transporter activity(GO:0015193) alanine transmembrane transporter activity(GO:0022858)
0.1 1.6 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 0.6 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1 0.5 GO:0004630 phospholipase D activity(GO:0004630)
0.1 0.7 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1 0.5 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 0.6 GO:0030332 cyclin binding(GO:0030332)
0.1 0.9 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 0.4 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.1 0.2 GO:0000829 inositol heptakisphosphate kinase activity(GO:0000829) diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.1 0.2 GO:0030366 molybdopterin synthase activity(GO:0030366)
0.1 0.5 GO:0004985 opioid receptor activity(GO:0004985)
0.1 0.7 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.1 2.0 GO:0015036 disulfide oxidoreductase activity(GO:0015036)
0.0 0.3 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.2 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.0 1.1 GO:0031267 small GTPase binding(GO:0031267)
0.0 0.2 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0 0.3 GO:0032051 clathrin light chain binding(GO:0032051)
0.0 0.3 GO:0016361 activin receptor activity, type I(GO:0016361)
0.0 0.8 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.2 GO:0019972 interleukin-12 binding(GO:0019972) interleukin-12 alpha subunit binding(GO:0042164)
0.0 1.2 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.5 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 1.1 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.4 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 0.4 GO:0005158 insulin receptor binding(GO:0005158)
0.0 0.5 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 1.4 GO:0005109 frizzled binding(GO:0005109)
0.0 1.4 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 0.4 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.2 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.0 0.6 GO:0015923 mannosidase activity(GO:0015923)
0.0 0.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.2 GO:0030504 inorganic diphosphate transmembrane transporter activity(GO:0030504)
0.0 0.2 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.7 GO:0048038 quinone binding(GO:0048038)
0.0 0.5 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 3.0 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.1 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0 1.1 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 0.2 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.7 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.1 GO:0015086 cadmium ion transmembrane transporter activity(GO:0015086)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.6 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.4 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 0.5 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 1.4 GO:0019843 rRNA binding(GO:0019843)
0.0 0.5 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.6 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.7 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 0.1 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.0 0.3 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 1.4 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 3.0 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.4 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 1.1 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.8 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 2.8 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 0.5 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.3 GO:0010484 H3 histone acetyltransferase activity(GO:0010484) histone acetyltransferase activity (H3-K23 specific)(GO:0043994)
0.0 0.9 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.5 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.2 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.7 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 0.3 GO:0008417 fucosyltransferase activity(GO:0008417)
0.0 1.1 GO:0017124 SH3 domain binding(GO:0017124)
0.0 1.3 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 3.0 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 0.9 GO:0008013 beta-catenin binding(GO:0008013)
0.0 1.3 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.4 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 1.2 GO:0003724 RNA helicase activity(GO:0003724)
0.0 0.1 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.0 0.9 GO:0004521 endoribonuclease activity(GO:0004521)
0.0 0.5 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.2 GO:0050700 CARD domain binding(GO:0050700)
0.0 1.9 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 0.1 GO:0004419 hydroxymethylglutaryl-CoA lyase activity(GO:0004419)
0.0 0.7 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.9 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.3 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.0 0.4 GO:0042923 neuropeptide binding(GO:0042923)
0.0 0.1 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.3 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.2 GO:0002039 p53 binding(GO:0002039)
0.0 0.8 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 2.0 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.4 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 1.9 GO:0042393 histone binding(GO:0042393)
0.0 18.4 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0 3.4 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.9 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.1 1.6 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.1 6.6 PID E2F PATHWAY E2F transcription factor network
0.1 1.2 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.1 0.8 PID S1P S1P4 PATHWAY S1P4 pathway
0.1 0.9 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.1 1.4 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.1 1.8 ST GA13 PATHWAY G alpha 13 Pathway
0.1 1.8 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 2.6 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.7 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 1.7 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.5 PID IL3 PATHWAY IL3-mediated signaling events
0.0 1.7 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.7 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 0.7 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.0 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.7 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.0 0.6 PID SHP2 PATHWAY SHP2 signaling
0.0 0.4 PID FAS PATHWAY FAS (CD95) signaling pathway
0.0 0.3 PID ATM PATHWAY ATM pathway
0.0 0.6 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.5 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 2.0 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 6.7 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.3 3.7 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.2 1.6 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.2 3.4 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 1.4 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.1 1.6 REACTOME SOS MEDIATED SIGNALLING Genes involved in SOS-mediated signalling
0.1 2.7 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 1.2 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.1 0.6 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.1 1.6 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.1 0.9 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 1.1 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.1 0.6 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 3.3 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 0.6 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 0.7 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.1 0.9 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 0.5 REACTOME FGFR1 LIGAND BINDING AND ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.1 0.8 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.1 2.4 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 1.4 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.3 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.0 0.5 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.4 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 1.7 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 1.4 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.4 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
0.0 1.1 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 1.9 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.9 REACTOME HEPARAN SULFATE HEPARIN HS GAG METABOLISM Genes involved in Heparan sulfate/heparin (HS-GAG) metabolism
0.0 0.6 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.4 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.5 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.7 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.7 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.5 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.3 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.6 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA