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PRJEB1986: zebrafish developmental stages transcriptome

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Results for tp53

Z-value: 0.73

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Transcription factors associated with tp53

Gene Symbol Gene ID Gene Info
tp53
ENSDARG00000035559 tumor protein p53
tp53
ENSDARG00000115148 tumor protein p53

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tp53dr11_v1_chr5_+_24086227_240862270.871.5e-06Click!

Activity profile of tp53 motif

Sorted Z-values of tp53 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr20_-_27225876 2.19 ENSDART00000149204
ENSDART00000149732
si:dkey-85n7.7
si:dkey-85n7.7
chr4_+_23127284 2.12 ENSDART00000122675
mdm2
MDM2 oncogene, E3 ubiquitin protein ligase
chr4_+_23127104 2.06 ENSDART00000139543
mdm2
MDM2 oncogene, E3 ubiquitin protein ligase
chr24_+_22485710 2.05 ENSDART00000146058
si:dkey-40h20.1
si:dkey-40h20.1
chr25_-_7520937 2.00 ENSDART00000170050
cdkn1cb
cyclin-dependent kinase inhibitor 1Cb
chr14_+_22132896 1.86 ENSDART00000138274
ccng1
cyclin G1
chr4_+_23126558 1.79 ENSDART00000162859
mdm2
MDM2 oncogene, E3 ubiquitin protein ligase
chr5_+_24089334 1.75 ENSDART00000183748
tp53
tumor protein p53
chr7_+_26049818 1.70 ENSDART00000173611
si:dkey-6n21.12
si:dkey-6n21.12
chr17_+_25849332 1.62 ENSDART00000191994
acss1
acyl-CoA synthetase short chain family member 1
chr10_+_38512270 1.58 ENSDART00000109752
serpinh1a
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1a
chr21_-_19919020 1.55 ENSDART00000147396
ppp1r3b
protein phosphatase 1, regulatory subunit 3B
chr3_+_23692462 1.43 ENSDART00000145934
hoxb7a
homeobox B7a
chr4_+_25607743 1.40 ENSDART00000028297
acot14
acyl-CoA thioesterase 14
chr9_+_29671553 1.39 ENSDART00000015377
rnaseh2b
ribonuclease H2, subunit B
chr22_+_2598998 1.38 ENSDART00000176665
CU570894.1

chr12_+_27537357 1.38 ENSDART00000136212
etv4
ets variant 4
chr23_+_4483083 1.38 ENSDART00000092389
nup210
nucleoporin 210
chr19_-_27462720 1.37 ENSDART00000135901
si:ch73-25f10.6
si:ch73-25f10.6
chr23_+_23232136 1.35 ENSDART00000126479
ENSDART00000187764
plekhn1
pleckstrin homology domain containing, family N member 1
chr3_+_16229911 1.33 ENSDART00000121728
rpl19
ribosomal protein L19
chr23_-_33775145 1.29 ENSDART00000132147
ENSDART00000027959
ENSDART00000160116
racgap1
Rac GTPase activating protein 1
chr8_+_15277874 1.29 ENSDART00000146965
dnttip2
deoxynucleotidyltransferase, terminal, interacting protein 2
chr8_+_28593707 1.28 ENSDART00000097213
tcf15
transcription factor 15
chr7_+_38809241 1.19 ENSDART00000190979
harbi1
harbinger transposase derived 1
chr15_+_29113616 1.15 ENSDART00000190015
ENSDART00000191099
capns1b
calpain, small subunit 1 b
chr12_-_5505205 1.13 ENSDART00000092319
abi3b
ABI family, member 3b
chr25_+_19095231 1.10 ENSDART00000154066
isg20
interferon stimulated exonuclease gene
chr6_-_7109063 1.10 ENSDART00000148548
nhej1
nonhomologous end-joining factor 1
chr25_+_36292465 1.09 ENSDART00000152649
bmb
brambleberry
chr18_-_16924221 1.08 ENSDART00000122102
wee1
WEE1 G2 checkpoint kinase
chr5_+_29831235 1.08 ENSDART00000109660
f11r.1
F11 receptor, tandem duplicate 1
chr12_-_33789006 1.05 ENSDART00000034550
llgl2
lethal giant larvae homolog 2 (Drosophila)
chr7_-_26049282 1.04 ENSDART00000136389
ENSDART00000101124
rnaseka
ribonuclease, RNase K a
chr7_-_17816921 1.01 ENSDART00000149821
ecsit
ECSIT signalling integrator
chr11_+_25328199 0.98 ENSDART00000141478
ENSDART00000112209
fam83d
family with sequence similarity 83, member D
chr3_-_49815223 0.98 ENSDART00000181208
gcgra
glucagon receptor a
chr16_-_40459104 0.97 ENSDART00000032389
plekhf2
pleckstrin homology domain containing, family F (with FYVE domain) member 2
chr14_+_14027427 0.97 ENSDART00000183204
rraga
Ras-related GTP binding A
chr15_+_35043007 0.94 ENSDART00000086954
sesn3
sestrin 3
chr4_-_8779141 0.93 ENSDART00000182314
ENSDART00000172376
ttll12
tubulin tyrosine ligase-like family, member 12
chr8_+_23639124 0.93 ENSDART00000083108
nt5dc2
5'-nucleotidase domain containing 2
chr19_+_3215466 0.93 ENSDART00000181288
zgc:86598
zgc:86598
chr12_+_6098713 0.92 ENSDART00000139054
sgms1
sphingomyelin synthase 1
chr23_-_5783421 0.91 ENSDART00000131521
ENSDART00000019455
csrp1a
cysteine and glycine-rich protein 1a
chr16_-_34195002 0.89 ENSDART00000054026
rcc1
regulator of chromosome condensation 1
chr16_+_38201840 0.87 ENSDART00000044971
myo1eb
myosin IE, b
chr8_-_17926620 0.87 ENSDART00000187864
lhx8b
LIM homeobox 8b
chr8_-_17926814 0.82 ENSDART00000147344
lhx8b
LIM homeobox 8b
chr18_+_14619544 0.82 ENSDART00000010821
utp4
UTP4, small subunit processome component
chr12_-_33789218 0.79 ENSDART00000193258
llgl2
lethal giant larvae homolog 2 (Drosophila)
chr6_+_43450221 0.79 ENSDART00000075521
zgc:113054
zgc:113054
chr3_+_24595922 0.79 ENSDART00000169405
si:dkey-68o6.5
si:dkey-68o6.5
chr3_-_36602069 0.79 ENSDART00000165414
rrn3
RRN3 homolog, RNA polymerase I transcription factor
chr1_-_18592068 0.78 ENSDART00000082063
fam114a1
family with sequence similarity 114, member A1
chr4_-_16833518 0.76 ENSDART00000179867
ldhba
lactate dehydrogenase Ba
chr16_+_20496691 0.76 ENSDART00000182737
ENSDART00000078984
cpvl
carboxypeptidase, vitellogenic-like
chr8_-_4694458 0.75 ENSDART00000019828
zgc:63587
zgc:63587
chr20_-_23171430 0.73 ENSDART00000109234
spata18
spermatogenesis associated 18
chr8_-_13362757 0.72 ENSDART00000188608
ccdc124
coiled-coil domain containing 124
chr2_-_37837472 0.71 ENSDART00000165347
mettl17
methyltransferase like 17
chr13_-_25774183 0.71 ENSDART00000046981
pdlim1
PDZ and LIM domain 1 (elfin)
chr9_+_41474623 0.71 ENSDART00000137187
nemp2
nuclear envelope integral membrane protein 2
chr24_-_15159658 0.71 ENSDART00000142473
rttn
rotatin
chr2_+_37837249 0.71 ENSDART00000113337
parp2
poly (ADP-ribose) polymerase 2
chr22_+_1947494 0.69 ENSDART00000159121
si:dkey-15h8.15
si:dkey-15h8.15
chr3_+_30922947 0.69 ENSDART00000184060
cldni
claudin i
chr21_-_41065369 0.68 ENSDART00000143749
larsb
leucyl-tRNA synthetase b
chr23_-_5759242 0.68 ENSDART00000055087
phlda3
pleckstrin homology-like domain, family A, member 3
chr5_+_27898226 0.67 ENSDART00000098604
ENSDART00000180251
adam28
ADAM metallopeptidase domain 28
chr7_-_20464133 0.66 ENSDART00000078192
cnpy4
canopy4
chr16_-_48400639 0.66 ENSDART00000159372
eif3ha
eukaryotic translation initiation factor 3, subunit H, a
chr9_+_55075526 0.65 ENSDART00000139555
ENSDART00000133864
gpr143
G protein-coupled receptor 143
chr15_-_29387446 0.64 ENSDART00000145976
ENSDART00000035096
serpinh1b
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1b
chr6_+_49095646 0.63 ENSDART00000103385
slc25a55a
solute carrier family 25, member 55a
chr5_-_69804433 0.62 ENSDART00000028954
rilpl2
Rab interacting lysosomal protein-like 2
chr3_+_35812040 0.61 ENSDART00000075903
ENSDART00000147712
crlf3
cytokine receptor-like factor 3
chr21_+_5932140 0.61 ENSDART00000193767
rexo4
REX4 homolog, 3'-5' exonuclease
chr17_-_22137199 0.59 ENSDART00000089689
mrps5
mitochondrial ribosomal protein S5
chr13_+_28705143 0.59 ENSDART00000183338
ldb1a
LIM domain binding 1a
chr15_-_25093680 0.59 ENSDART00000062695
exo5
exonuclease 5
chr3_+_22345497 0.59 ENSDART00000191274
ENSDART00000129697
ENSDART00000193100
ifnphi3
interferon phi 3
chr17_-_10838434 0.58 ENSDART00000064597
lgals3b
lectin, galactoside binding soluble 3b
chr3_-_31078348 0.58 ENSDART00000055360
elob
elongin B
chr10_+_8629275 0.58 ENSDART00000129643
aplnrb
apelin receptor b
chr8_-_48770603 0.57 ENSDART00000159712
pimr184
Pim proto-oncogene, serine/threonine kinase, related 184
chr15_-_18067220 0.57 ENSDART00000113142
phldb1b
pleckstrin homology-like domain, family B, member 1b
chr7_+_22688781 0.54 ENSDART00000173509
ugt5g1
UDP glucuronosyltransferase 5 family, polypeptide G1
chr18_+_35861930 0.54 ENSDART00000185223
ppp1r13l
protein phosphatase 1, regulatory subunit 13 like
chr15_+_44053244 0.54 ENSDART00000059550
lrrc51
leucine rich repeat containing 51
chr6_-_43283122 0.53 ENSDART00000186022
frmd4ba
FERM domain containing 4Ba
chr4_+_13931578 0.53 ENSDART00000142466
pphln1
periphilin 1
chr16_-_32006737 0.51 ENSDART00000184813
ENSDART00000179827
gstk4
glutathione S-transferase kappa 4
chr15_-_25094026 0.51 ENSDART00000129154
exo5
exonuclease 5
chr5_+_27404946 0.51 ENSDART00000121886
ENSDART00000005025
hdr
hematopoietic death receptor
chr6_-_18960105 0.50 ENSDART00000185278
ENSDART00000162968
sept9b
septin 9b
chr12_+_29236274 0.50 ENSDART00000006505
mxtx2
mix-type homeobox gene 2
chr16_-_30931468 0.50 ENSDART00000187838
slc45a4
solute carrier family 45, member 4
chr10_-_4980150 0.49 ENSDART00000093228
mat2al
methionine adenosyltransferase II, alpha-like
chr23_+_11285662 0.48 ENSDART00000111028
chl1a
cell adhesion molecule L1-like a
chr3_-_47294365 0.48 ENSDART00000191039
tnfsf18
TNF superfamily member 18
chr2_-_51316187 0.47 ENSDART00000163362
ENSDART00000166871
ENSDART00000160262
pigrl3.5
polymeric immunoglobulin receptor-like 3.5
chr11_+_42641404 0.47 ENSDART00000172641
ENSDART00000169938
il17rd
interleukin 17 receptor D
chr23_-_1017428 0.46 ENSDART00000110588
ENSDART00000183158
cdh26.1
cadherin 26, tandem duplicate 1
chr5_+_57924611 0.44 ENSDART00000050949
btg4
B-cell translocation gene 4
chr8_+_7322465 0.44 ENSDART00000192380
ssuh2rs1
ssu-2 homolog, related sequence 1
chr16_-_9423735 0.44 ENSDART00000185645
ccr8.1
chemokine (C-C motif) receptor 8.1
chr19_-_25114701 0.44 ENSDART00000149035
ptp4a3
protein tyrosine phosphatase type IVA, member 3
chr23_-_1017605 0.43 ENSDART00000138290
cdh26.1
cadherin 26, tandem duplicate 1
chr2_-_27900518 0.43 ENSDART00000109561
ENSDART00000077720
zgc:163121
zgc:163121
chr15_+_17343319 0.43 ENSDART00000018461
vmp1
vacuole membrane protein 1
chr7_+_48805534 0.42 ENSDART00000145375
ENSDART00000148744
cpt1aa
carnitine palmitoyltransferase 1Aa (liver)
chr15_-_23761580 0.42 ENSDART00000137918
bbc3
BCL2 binding component 3
chr4_+_34417403 0.41 ENSDART00000186032
ENSDART00000167909
si:ch211-246b8.2
si:ch211-246b8.2
chr20_+_42537768 0.41 ENSDART00000134066
ENSDART00000153434
si:dkeyp-93d12.1
si:dkeyp-93d12.1
chr11_+_2434262 0.39 ENSDART00000166445
csnk2a4
casein kinase 2, alpha 4 polypeptide
chr16_-_42175617 0.39 ENSDART00000084715
alkbh8
alkB homolog 8, tRNA methyltransferase
chr14_+_29941266 0.37 ENSDART00000112757
fam149a
family with sequence similarity 149 member A
chr7_+_54260004 0.37 ENSDART00000171909
pacsin3
protein kinase C and casein kinase substrate in neurons 3
chr16_+_34111919 0.37 ENSDART00000134037
ENSDART00000006061
ENSDART00000140552
tcea3
transcription elongation factor A (SII), 3
chr25_-_27735290 0.37 ENSDART00000140663
zgc:153935
zgc:153935
chr20_-_23656516 0.37 ENSDART00000149735
cbr4
carbonyl reductase 4
chr12_+_48784731 0.35 ENSDART00000158348
zmiz1b
zinc finger, MIZ-type containing 1b
chr25_-_36292346 0.35 ENSDART00000073399
faap24
Fanconi anemia core complex associated protein 24
chr19_+_41551543 0.35 ENSDART00000112364
si:ch211-57n23.4
si:ch211-57n23.4
chr7_-_8438657 0.34 ENSDART00000173054
si:dkeyp-32g11.8
si:dkeyp-32g11.8
chr4_-_13931508 0.34 ENSDART00000067174
zcrb1
zinc finger CCHC-type and RNA binding motif 1
chr13_+_1726953 0.33 ENSDART00000103004
zmp:0000000760
zmp:0000000760
chr25_-_17910714 0.32 ENSDART00000191586
arntl1a
aryl hydrocarbon receptor nuclear translocator-like 1a
chr19_-_27570333 0.32 ENSDART00000146562
ENSDART00000179060
si:dkeyp-46h3.5
si:dkeyp-46h3.8
si:dkeyp-46h3.5
si:dkeyp-46h3.8
chr5_+_59449762 0.32 ENSDART00000150230
clip2
CAP-GLY domain containing linker protein 2
chr19_-_3381422 0.31 ENSDART00000105146
edn1
endothelin 1
chr11_+_10975481 0.31 ENSDART00000160488
itgb6
integrin, beta 6
chr15_+_28175638 0.30 ENSDART00000037119
slc46a1
solute carrier family 46 (folate transporter), member 1
chr5_-_37959874 0.29 ENSDART00000031719
mpzl2b
myelin protein zero-like 2b
chr4_-_13931293 0.28 ENSDART00000067172
zcrb1
zinc finger CCHC-type and RNA binding motif 1
chr16_-_33806390 0.27 ENSDART00000160671
rspo1
R-spondin 1
chr6_+_59913147 0.27 ENSDART00000156543
aamp
angio-associated, migratory cell protein
chr15_-_43238220 0.27 ENSDART00000027019
wdfy1
WD repeat and FYVE domain containing 1
chr3_+_26064091 0.27 ENSDART00000143697
si:dkeyp-69e1.8
si:dkeyp-69e1.8
chr22_+_24770744 0.27 ENSDART00000142882
si:rp71-23d18.4
si:rp71-23d18.4
chr10_+_36029537 0.27 ENSDART00000165386
hmgb1a
high mobility group box 1a
chr11_+_14295011 0.26 ENSDART00000060226
si:ch211-262i1.4
si:ch211-262i1.4
chr4_+_13931733 0.26 ENSDART00000141742
ENSDART00000067175
pphln1
periphilin 1
chr17_-_8268406 0.26 ENSDART00000149873
ENSDART00000064668
ENSDART00000148403
ahi1
Abelson helper integration site 1
chr3_-_50147160 0.25 ENSDART00000191341
btr02
bloodthirsty-related gene family, member 2
chr12_+_19320657 0.24 ENSDART00000100075
ENSDART00000066389
tmem184ba
transmembrane protein 184ba
chr17_-_23412705 0.23 ENSDART00000126995
si:ch211-149k12.3
si:ch211-149k12.3
chr1_+_57371447 0.22 ENSDART00000152229
ENSDART00000181077
si:dkey-27j5.3
si:dkey-27j5.3
chr1_+_45969240 0.22 ENSDART00000042086
arhgef7b
Rho guanine nucleotide exchange factor (GEF) 7b
chr23_-_15090782 0.22 ENSDART00000133624
si:ch211-218g4.2
si:ch211-218g4.2
chr23_+_20863145 0.21 ENSDART00000129992
pax7b
paired box 7b
chr5_-_29570141 0.21 ENSDART00000043259
entpd2a.2
ectonucleoside triphosphate diphosphohydrolase 2a, tandem duplicate 2
chr16_+_35595312 0.20 ENSDART00000170438
si:ch211-1i11.3
si:ch211-1i11.3
chr3_-_50277959 0.20 ENSDART00000082773
ENSDART00000139524
arl16
ADP-ribosylation factor-like 16
chr17_-_27200025 0.20 ENSDART00000192699
asap3
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
chr12_+_22576404 0.20 ENSDART00000172053
capgb
capping protein (actin filament), gelsolin-like b
chr1_-_29758947 0.19 ENSDART00000049514
ENSDART00000183571
ENSDART00000140345
alg11
asparagine-linked glycosylation 11 (alpha-1,2-mannosyltransferase)
chr24_-_30862168 0.19 ENSDART00000168540
ptbp2a
polypyrimidine tract binding protein 2a
chr1_-_9134045 0.18 ENSDART00000142132
palb2
partner and localizer of BRCA2
chr19_+_25154066 0.18 ENSDART00000163220
si:ch211-239d6.2
si:ch211-239d6.2
chr25_-_1124851 0.18 ENSDART00000067558
spg11
spastic paraplegia 11
chr14_+_28438947 0.17 ENSDART00000006489
acsl4a
acyl-CoA synthetase long chain family member 4a
chr18_-_22717565 0.17 ENSDART00000142185
ENSDART00000059945
si:ch73-113g13.1
si:ch73-113g13.1
chr1_-_11596829 0.17 ENSDART00000140725
si:dkey-26i13.7
si:dkey-26i13.7
chr11_+_10975012 0.17 ENSDART00000192872
itgb6
integrin, beta 6
chr21_-_18648861 0.16 ENSDART00000112113
si:dkey-112m2.1
si:dkey-112m2.1
chr16_+_53387085 0.16 ENSDART00000154223
ENSDART00000101404
kif13a
kinesin family member 13A
chr22_+_9793923 0.16 ENSDART00000063323
si:dkey-102c8.2
si:dkey-102c8.2
chr18_+_33340868 0.15 ENSDART00000099139
v2rh14
vomeronasal 2 receptor, h14
chr23_-_31512496 0.15 ENSDART00000158755
ENSDART00000143425
eya4
EYA transcriptional coactivator and phosphatase 4
chr9_-_3958533 0.15 ENSDART00000129091
ubr3
ubiquitin protein ligase E3 component n-recognin 3
chr21_+_32332616 0.15 ENSDART00000154105
si:ch211-247j9.1
si:ch211-247j9.1
chr3_+_3992590 0.15 ENSDART00000180211
ENSDART00000054840
BX005421.2

chr4_-_40589466 0.14 ENSDART00000133295
ENSDART00000124872
si:dkey-207m2.4
si:dkey-207m2.4
chr7_+_4583139 0.14 ENSDART00000143777
si:dkey-83f18.4
si:dkey-83f18.4
chr23_-_31428763 0.13 ENSDART00000053545
zgc:153284
zgc:153284
chr1_+_27070760 0.13 ENSDART00000186790
bnc2
basonuclin 2
chr3_-_22359119 0.13 ENSDART00000168184
ifnphi2
interferon phi 2
chr11_+_6281647 0.13 ENSDART00000002459
ctns
cystinosin, lysosomal cystine transporter
chr19_+_43780970 0.12 ENSDART00000063870
rpl11
ribosomal protein L11
chr19_+_44009473 0.12 ENSDART00000151004
nkd3
naked cuticle homolog 3
chr22_+_9854088 0.12 ENSDART00000122678
BX539307.1

chr10_+_8554929 0.12 ENSDART00000190849
tbc1d10ab
TBC1 domain family, member 10Ab
chr6_+_13046720 0.12 ENSDART00000165896
casp8
caspase 8, apoptosis-related cysteine peptidase
chr9_+_50110763 0.11 ENSDART00000162990
cobll1b
cordon-bleu WH2 repeat protein-like 1b
chr10_+_40722256 0.11 ENSDART00000099154
taar19q
trace amine associated receptor 19q
chr22_+_14836040 0.11 ENSDART00000180951
gtpbp1l
GTP binding protein 1, like
chr6_-_42983843 0.11 ENSDART00000130666
tnfrsf18
tumor necrosis factor receptor superfamily, member 18
chr17_+_31585585 0.11 ENSDART00000154933
si:dkey-13p1.4
si:dkey-13p1.4
chr3_-_11040575 0.10 ENSDART00000159802
CR382337.2

chr4_-_70050522 0.10 ENSDART00000100252
si:ch211-171l17.14
si:ch211-171l17.14
chr17_-_40879108 0.10 ENSDART00000010362
supt7l
SPT7-like STAGA complex gamma subunit
chr4_+_25630555 0.10 ENSDART00000133425
acot15
acyl-CoA thioesterase 15
chr18_-_31916845 0.10 ENSDART00000165908
olfcs2
olfactory receptor C family, s2
chr10_-_27566481 0.09 ENSDART00000078920
auts2a
autism susceptibility candidate 2a
chr19_+_34274504 0.09 ENSDART00000132046
si:ch211-9n13.3
si:ch211-9n13.3
chr19_-_25149034 0.09 ENSDART00000148432
ENSDART00000175266
ptp4a3
protein tyrosine phosphatase type IVA, member 3
chr17_+_40879331 0.08 ENSDART00000046003
slc4a1ap
solute carrier family 4 (anion exchanger), member 1, adaptor protein
chr12_-_16380961 0.07 ENSDART00000086984
hectd2
HECT domain containing 2

Network of associatons between targets according to the STRING database.

First level regulatory network of tp53

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 6.0 GO:1904036 negative regulation of epithelial cell apoptotic process(GO:1904036)
0.6 1.7 GO:0010525 regulation of transposition, RNA-mediated(GO:0010525) negative regulation of transposition, RNA-mediated(GO:0010526) transposition, RNA-mediated(GO:0032197) positive regulation of neuron apoptotic process(GO:0043525) positive regulation of neuron death(GO:1901216)
0.5 1.6 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.4 1.8 GO:0008594 photoreceptor cell morphogenesis(GO:0008594) negative regulation of epithelial to mesenchymal transition(GO:0010719)
0.3 1.3 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.3 1.0 GO:2000425 regulation of apoptotic cell clearance(GO:2000425)
0.3 2.0 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.3 1.7 GO:0035332 positive regulation of hippo signaling(GO:0035332)
0.3 1.6 GO:0019427 acetate metabolic process(GO:0006083) acetyl-CoA biosynthetic process from acetate(GO:0019427)
0.2 1.1 GO:0000741 karyogamy(GO:0000741) pronuclear fusion(GO:0007344)
0.2 1.2 GO:0090280 positive regulation of calcium ion import(GO:0090280)
0.2 0.8 GO:0097355 protein localization to heterochromatin(GO:0097355)
0.1 1.0 GO:0061635 regulation of protein complex stability(GO:0061635)
0.1 0.9 GO:0043201 response to leucine(GO:0043201) cellular response to leucine(GO:0071233) regulation of response to reactive oxygen species(GO:1901031)
0.1 0.9 GO:1901673 regulation of mitotic spindle assembly(GO:1901673)
0.1 0.5 GO:0036462 TRAIL-activated apoptotic signaling pathway(GO:0036462)
0.1 0.6 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.1 0.7 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.1 0.9 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.1 0.8 GO:0006361 transcription initiation from RNA polymerase I promoter(GO:0006361)
0.1 0.7 GO:0050848 regulation of calcium-mediated signaling(GO:0050848)
0.1 1.4 GO:0035108 limb morphogenesis(GO:0035108)
0.1 0.4 GO:0090199 regulation of release of cytochrome c from mitochondria(GO:0090199) positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.1 1.1 GO:0050892 intestinal absorption(GO:0050892)
0.1 0.2 GO:0071896 protein localization to adherens junction(GO:0071896)
0.1 1.8 GO:0021884 forebrain neuron development(GO:0021884)
0.1 0.5 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.1 2.5 GO:0030199 collagen fibril organization(GO:0030199)
0.1 0.6 GO:0015800 acidic amino acid transport(GO:0015800) aspartate transport(GO:0015810) L-glutamate transport(GO:0015813) malate-aspartate shuttle(GO:0043490)
0.1 0.7 GO:0051898 negative regulation of protein kinase B signaling(GO:0051898)
0.1 0.3 GO:0014826 regulation of systemic arterial blood pressure by endothelin(GO:0003100) vein smooth muscle contraction(GO:0014826) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.1 1.0 GO:0051310 metaphase plate congression(GO:0051310)
0.1 0.4 GO:0051290 protein heterotetramerization(GO:0051290)
0.0 1.4 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 0.2 GO:0050938 regulation of xanthophore differentiation(GO:0050938)
0.0 0.4 GO:0031998 regulation of fatty acid beta-oxidation(GO:0031998)
0.0 1.1 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)
0.0 0.5 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.0 0.4 GO:0042953 lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
0.0 0.1 GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism(GO:0043903)
0.0 1.5 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 0.3 GO:0044458 motile cilium assembly(GO:0044458)
0.0 0.6 GO:0003382 epithelial cell morphogenesis(GO:0003382)
0.0 0.2 GO:0071405 response to methanol(GO:0033986) cellular response to methanol(GO:0071405)
0.0 0.5 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.0 0.4 GO:0014028 notochord formation(GO:0014028)
0.0 0.5 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.2 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0 0.2 GO:1900744 regulation of p38MAPK cascade(GO:1900744)
0.0 1.0 GO:0003094 glomerular filtration(GO:0003094)
0.0 1.0 GO:0010906 regulation of glucose metabolic process(GO:0010906)
0.0 0.8 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 2.5 GO:0061640 cytoskeleton-dependent cytokinesis(GO:0061640)
0.0 0.1 GO:1900028 wound healing, spreading of epidermal cells(GO:0035313) negative regulation of ruffle assembly(GO:1900028)
0.0 0.7 GO:0001732 formation of cytoplasmic translation initiation complex(GO:0001732)
0.0 1.3 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.0 0.4 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.2 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0 1.0 GO:0031102 neuron projection regeneration(GO:0031102)
0.0 1.1 GO:0007093 mitotic cell cycle checkpoint(GO:0007093)
0.0 0.2 GO:0016576 histone dephosphorylation(GO:0016576) negative regulation of signal transduction in absence of ligand(GO:1901099) regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001239) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.0 0.4 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.0 1.6 GO:0035383 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.0 0.5 GO:0033627 cell adhesion mediated by integrin(GO:0033627)
0.0 0.7 GO:0061726 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.0 0.7 GO:0043297 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.0 0.2 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 1.0 GO:0090305 nucleic acid phosphodiester bond hydrolysis(GO:0090305)
0.0 0.2 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.0 0.5 GO:0001706 endoderm formation(GO:0001706)
0.0 0.5 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.4 GO:0042476 odontogenesis(GO:0042476)
0.0 0.6 GO:0006368 transcription elongation from RNA polymerase II promoter(GO:0006368)
0.0 1.4 GO:0006401 RNA catabolic process(GO:0006401)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.2 1.1 GO:0032807 DNA ligase IV complex(GO:0032807)
0.2 1.0 GO:1990131 EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.2 0.5 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.1 0.9 GO:0061700 GATOR2 complex(GO:0061700)
0.1 1.3 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.1 0.6 GO:0030891 VCB complex(GO:0030891)
0.1 1.6 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 1.0 GO:0097431 mitotic spindle pole(GO:0097431)
0.1 0.6 GO:0001772 immunological synapse(GO:0001772)
0.1 0.7 GO:0042788 polysomal ribosome(GO:0042788)
0.1 0.7 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 1.8 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 1.3 GO:0032156 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 1.5 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.4 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.8 GO:0030686 90S preribosome(GO:0030686)
0.0 0.6 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.6 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.6 GO:0045180 basal cortex(GO:0045180)
0.0 1.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.3 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 1.4 GO:0005643 nuclear pore(GO:0005643)
0.0 0.7 GO:0030496 midbody(GO:0030496)
0.0 6.5 GO:0005730 nucleolus(GO:0005730)
0.0 2.3 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 1.5 GO:0030027 lamellipodium(GO:0030027)
0.0 0.9 GO:0016342 catenin complex(GO:0016342)
0.0 1.6 GO:0030018 Z disc(GO:0030018)
0.0 0.4 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 0.9 GO:0005902 microvillus(GO:0005902)
0.0 0.7 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 1.0 GO:0031901 early endosome membrane(GO:0031901)
0.0 1.3 GO:0036064 ciliary basal body(GO:0036064)
0.0 0.1 GO:0030914 STAGA complex(GO:0030914)
0.0 0.9 GO:0031228 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.0 0.3 GO:0035371 microtubule plus-end(GO:0035371)
0.0 1.2 GO:0005741 mitochondrial outer membrane(GO:0005741)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:1901612 cardiolipin binding(GO:1901612)
0.4 1.1 GO:0045145 single-stranded DNA 5'-3' exodeoxyribonuclease activity(GO:0045145)
0.3 1.6 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.3 2.0 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.2 0.7 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.2 0.7 GO:0072545 tyrosine binding(GO:0072545)
0.2 1.0 GO:0016519 gastric inhibitory peptide receptor activity(GO:0016519)
0.2 0.8 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.2 0.9 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.2 0.8 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.1 0.9 GO:0070728 leucine binding(GO:0070728)
0.1 0.4 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.1 0.1 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.1 0.5 GO:0004478 methionine adenosyltransferase activity(GO:0004478)
0.1 0.6 GO:0019865 IgE binding(GO:0019863) immunoglobulin binding(GO:0019865)
0.1 0.6 GO:0060182 apelin receptor activity(GO:0060182)
0.1 0.8 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 1.8 GO:0045159 myosin II binding(GO:0045159)
0.1 1.6 GO:2001069 glycogen binding(GO:2001069)
0.1 0.6 GO:0030274 LIM domain binding(GO:0030274)
0.1 1.7 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 0.2 GO:0004377 GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity(GO:0004377)
0.1 0.3 GO:0031708 endothelin B receptor binding(GO:0031708)
0.1 0.4 GO:0016416 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.1 1.6 GO:0042805 actinin binding(GO:0042805)
0.1 0.3 GO:0005542 folic acid binding(GO:0005542)
0.1 2.2 GO:0005518 collagen binding(GO:0005518)
0.1 1.4 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.1 1.2 GO:0048038 quinone binding(GO:0048038)
0.1 0.6 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.0 0.5 GO:1990404 protein ADP-ribosylase activity(GO:1990404)
0.0 0.5 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 0.7 GO:0070122 isopeptidase activity(GO:0070122)
0.0 5.8 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 1.1 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 1.5 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.5 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.1 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.0 0.6 GO:0008408 3'-5' exonuclease activity(GO:0008408)
0.0 0.4 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 1.1 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.9 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 1.0 GO:0004521 endoribonuclease activity(GO:0004521)
0.0 0.2 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.0 0.5 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.3 GO:0008301 DNA binding, bending(GO:0008301)
0.0 1.1 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 1.2 GO:0004518 nuclease activity(GO:0004518)
0.0 0.2 GO:0045134 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.0 0.4 GO:0019956 chemokine binding(GO:0019956) C-C chemokine binding(GO:0019957)
0.0 2.0 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.6 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.4 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 7.7 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1 1.1 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 1.6 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 2.5 PID P53 REGULATION PATHWAY p53 pathway
0.0 1.1 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.5 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.8 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 0.7 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 1.3 PID AURORA B PATHWAY Aurora B signaling
0.0 1.4 PID LKB1 PATHWAY LKB1 signaling events
0.0 1.1 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.5 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.9 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 0.1 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 1.0 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.7 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.5 PID FGF PATHWAY FGF signaling pathway
0.0 0.3 PID WNT SIGNALING PATHWAY Wnt signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 6.0 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.3 1.6 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.2 2.2 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.1 1.1 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 1.3 REACTOME KINESINS Genes involved in Kinesins
0.0 1.1 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 1.4 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0 0.8 REACTOME RNA POL I TRANSCRIPTION INITIATION Genes involved in RNA Polymerase I Transcription Initiation
0.0 0.6 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.3 REACTOME IRON UPTAKE AND TRANSPORT Genes involved in Iron uptake and transport
0.0 0.1 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.9 REACTOME LATE PHASE OF HIV LIFE CYCLE Genes involved in Late Phase of HIV Life Cycle
0.0 1.4 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.2 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway