Project

PRJEB1986: zebrafish developmental stages transcriptome

Navigation
Downloads

Results for tp73

Z-value: 0.75

Motif logo

logo of

Transcription factors associated with tp73

Gene Symbol Gene ID Gene Info
tp73
ENSDARG00000017953 tumor protein p73

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tp73dr11_v1_chr8_+_48858132_48858149-0.446.0e-02Click!

Activity profile of tp73 motif

Sorted Z-values of tp73 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_14333441 3.32 ENSDART00000171969
ptbp1b
polypyrimidine tract binding protein 1b
chr4_+_25680480 2.77 ENSDART00000100737
acot17
acyl-CoA thioesterase 17
chr2_+_44528255 1.99 ENSDART00000193834
pask
PAS domain containing serine/threonine kinase
chr4_+_23127104 1.83 ENSDART00000139543
mdm2
MDM2 oncogene, E3 ubiquitin protein ligase
chr9_-_52598343 1.69 ENSDART00000167922
xrcc5
X-ray repair complementing defective repair in Chinese hamster cells 5
chr5_+_40837539 1.61 ENSDART00000188279
si:dkey-3h3.3
si:dkey-3h3.3
chr2_+_37837249 1.61 ENSDART00000113337
parp2
poly (ADP-ribose) polymerase 2
chr4_+_23127284 1.50 ENSDART00000122675
mdm2
MDM2 oncogene, E3 ubiquitin protein ligase
chr3_+_31680592 1.47 ENSDART00000172456
mylk5
myosin, light chain kinase 5
chr7_+_41314862 1.41 ENSDART00000185198
zgc:165532
zgc:165532
chr11_+_24994705 1.40 ENSDART00000129211
zgc:92107
zgc:92107
chr2_-_37837472 1.40 ENSDART00000165347
mettl17
methyltransferase like 17
chr15_-_4485828 1.33 ENSDART00000062868
tfdp2
transcription factor Dp-2
chr4_+_23126558 1.32 ENSDART00000162859
mdm2
MDM2 oncogene, E3 ubiquitin protein ligase
chr14_+_22132896 1.32 ENSDART00000138274
ccng1
cyclin G1
chr3_+_16229911 1.30 ENSDART00000121728
rpl19
ribosomal protein L19
chr13_-_36418921 1.26 ENSDART00000135804
dcaf5
ddb1 and cul4 associated factor 5
chr23_-_20345473 1.23 ENSDART00000140935
si:rp71-17i16.6
si:rp71-17i16.6
chr25_+_36292465 1.16 ENSDART00000152649
bmb
brambleberry
chr11_+_7528599 0.87 ENSDART00000171813
adgrl2a
adhesion G protein-coupled receptor L2a
chr12_-_3077395 0.83 ENSDART00000002867
ENSDART00000126315
rfng
RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr18_+_45676788 0.79 ENSDART00000109948
ENSDART00000179864
qser1
glutamine and serine rich 1
chr7_-_73848458 0.78 ENSDART00000041385
zgc:163061
zgc:163061
chr2_-_48539673 0.77 ENSDART00000168202
CR391991.4

chr5_+_27898226 0.77 ENSDART00000098604
ENSDART00000180251
adam28
ADAM metallopeptidase domain 28
chr11_+_30303785 0.75 ENSDART00000185610
ENSDART00000126815
ugt1b5
UDP glucuronosyltransferase 1 family, polypeptide B5
chr19_-_7525588 0.74 ENSDART00000092256
mrpl9
mitochondrial ribosomal protein L9
chr7_-_22941472 0.72 ENSDART00000190334
tnfsf10l
TNF superfamily member 10, like
chr6_-_2154137 0.70 ENSDART00000162656
tgm5l
transglutaminase 5, like
chr18_+_20567542 0.70 ENSDART00000182585
bida
BH3 interacting domain death agonist
chr7_-_16596938 0.70 ENSDART00000134548
e2f8
E2F transcription factor 8
chr14_-_16328331 0.66 ENSDART00000111262
pcdh12
protocadherin 12
chr7_-_16597130 0.65 ENSDART00000144118
e2f8
E2F transcription factor 8
chr7_+_19495905 0.64 ENSDART00000125584
ENSDART00000173774
si:ch211-212k18.8
si:ch211-212k18.8
chr17_-_22324727 0.63 ENSDART00000160341
CU104709.1

chr22_-_9860792 0.63 ENSDART00000155908
si:dkey-253d23.2
si:dkey-253d23.2
chr11_+_16137302 0.63 ENSDART00000164892
pimr204
Pim proto-oncogene, serine/threonine kinase, related 204
chr15_-_29387446 0.62 ENSDART00000145976
ENSDART00000035096
serpinh1b
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1b
chr17_+_49091661 0.61 ENSDART00000177166
ENSDART00000177390
ENSDART00000190114
tiam2a
T cell lymphoma invasion and metastasis 2a
chr9_-_3671911 0.58 ENSDART00000102900
sp5a
Sp5 transcription factor a
chr23_+_42254960 0.58 ENSDART00000102980
zcchc11
zinc finger, CCHC domain containing 11
chr1_+_54773877 0.57 ENSDART00000129831
nlrc6
NLR family CARD domain containing 6
chr13_-_4707018 0.56 ENSDART00000128422
oit3
oncoprotein induced transcript 3
chr11_+_12175162 0.56 ENSDART00000125446
si:ch211-156l18.7
si:ch211-156l18.7
chr3_+_8825382 0.55 ENSDART00000158893
si:dkeyp-30d6.2
si:dkeyp-30d6.2
chr20_-_30376433 0.53 ENSDART00000190737
rps7
ribosomal protein S7
chr23_+_39346930 0.52 ENSDART00000102843
src
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr2_+_10771787 0.52 ENSDART00000187782
gfi1aa
growth factor independent 1A transcription repressor a
chr16_-_19568795 0.51 ENSDART00000185141
abcb5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr20_+_4157815 0.51 ENSDART00000113132
gnpat
glyceronephosphate O-acyltransferase
chr16_+_39196727 0.50 ENSDART00000017017
zdhhc3a
zinc finger, DHHC-type containing 3a
chr2_+_23352302 0.47 ENSDART00000187760
rnf2
ring finger protein 2
chr15_-_35960250 0.46 ENSDART00000186765
col4a4
collagen, type IV, alpha 4
chr1_-_53714885 0.41 ENSDART00000026409
cct4
chaperonin containing TCP1, subunit 4 (delta)
chr12_+_26608883 0.41 ENSDART00000153094
si:dkey-148d16.5
si:dkey-148d16.5
chr4_+_25693463 0.40 ENSDART00000132864
acot18
acyl-CoA thioesterase 18
chr23_+_39346774 0.40 ENSDART00000190985
src
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr11_+_24348425 0.40 ENSDART00000089747
nfs1
NFS1 cysteine desulfurase
chr13_+_33368140 0.40 ENSDART00000033848
brf1a
BRF1, RNA polymerase III transcription initiation factor a
chr2_-_7185460 0.38 ENSDART00000092078
rc3h1b
ring finger and CCCH-type domains 1b
chr4_+_25706037 0.36 ENSDART00000141133
lamb1b
laminin, beta 1b
chr25_-_3745393 0.34 ENSDART00000037973
morc2
MORC family CW-type zinc finger 2
chr3_+_52545400 0.33 ENSDART00000184183
slc27a1a
solute carrier family 27 (fatty acid transporter), member 1a
chr23_+_9258531 0.33 ENSDART00000138745
acss2
acyl-CoA synthetase short chain family member 2
chr22_-_31788170 0.29 ENSDART00000170925
pimr207
Pim proto-oncogene, serine/threonine kinase, related 207
chr18_-_38270077 0.29 ENSDART00000185546
caprin1b
cell cycle associated protein 1b
chr5_+_6854498 0.29 ENSDART00000148663
elac1
elaC ribonuclease Z 1
chr22_+_15979430 0.27 ENSDART00000189703
ENSDART00000192674
rc3h1a
ring finger and CCCH-type domains 1a
chr13_-_50546634 0.24 ENSDART00000192127
CU570781.2

chr9_+_33788389 0.23 ENSDART00000144623
kdm6a
lysine (K)-specific demethylase 6A
chr22_+_12477996 0.22 ENSDART00000177704
CR847870.3

chr7_+_19495379 0.22 ENSDART00000180514
si:ch211-212k18.8
si:ch211-212k18.8
chr3_+_62219158 0.22 ENSDART00000162354
BX470259.5

chr1_+_57371447 0.21 ENSDART00000152229
ENSDART00000181077
si:dkey-27j5.3
si:dkey-27j5.3
chr18_+_32916351 0.21 ENSDART00000170387
ENSDART00000161553
olfcg2
olfactory receptor C family, g2
chr3_-_39488639 0.20 ENSDART00000161644
zgc:100868
zgc:100868
chr2_+_36691771 0.20 ENSDART00000131978
ptx3b
pentraxin 3, long b
chr11_-_8208464 0.19 ENSDART00000161283
pimr203
Pim proto-oncogene, serine/threonine kinase, related 203
chr5_-_48307804 0.18 ENSDART00000182831
ENSDART00000186920
ENSDART00000183585
mef2cb
myocyte enhancer factor 2cb
chr10_+_36029537 0.18 ENSDART00000165386
hmgb1a
high mobility group box 1a
chr11_-_8271374 0.16 ENSDART00000168253
pimr202
Pim proto-oncogene, serine/threonine kinase, related 202
chr10_-_40479911 0.15 ENSDART00000136741
taar20d1
trace amine associated receptor 20d1
chr22_+_30331414 0.15 ENSDART00000133482
BX649448.3

chr6_+_48154954 0.12 ENSDART00000019706
phc2b
polyhomeotic homolog 2b (Drosophila)
chr16_-_21489514 0.12 ENSDART00000149525
ENSDART00000148517
ENSDART00000146914
ENSDART00000186493
ENSDART00000193081
ENSDART00000186017
mpp6a
membrane protein, palmitoylated 6a (MAGUK p55 subfamily member 6)
chr3_+_24577021 0.12 ENSDART00000158449
sp100.3
SP110 nuclear body protein, tandem duplicate 3
chr6_+_13046720 0.11 ENSDART00000165896
casp8
caspase 8, apoptosis-related cysteine peptidase
chr7_+_34487833 0.10 ENSDART00000173854
cln6a
CLN6, transmembrane ER protein a
chr1_+_55600504 0.10 ENSDART00000123946
umod
uromodulin
chr3_-_39488482 0.09 ENSDART00000135192
zgc:100868
zgc:100868
chr6_-_40885496 0.08 ENSDART00000189857
sirt4
sirtuin 4
chr6_-_43769332 0.08 ENSDART00000128174
foxp1b
forkhead box P1b
chr8_+_30747940 0.07 ENSDART00000098975
p2rx4b
purinergic receptor P2X, ligand-gated ion channel, 4b
chr8_+_52515188 0.07 ENSDART00000163668
si:ch1073-392o20.2
si:ch1073-392o20.2
chr21_-_27338639 0.05 ENSDART00000130632
hif1al2
hypoxia-inducible factor 1, alpha subunit, like 2
chr1_-_56363108 0.03 ENSDART00000021878
gcgrb
glucagon receptor b
chr12_+_22576404 0.03 ENSDART00000172053
capgb
capping protein (actin filament), gelsolin-like b
chr11_-_21363834 0.02 ENSDART00000080051
RASSF5
si:dkey-85p17.3
chr4_+_71018579 0.02 ENSDART00000186727
si:dkeyp-80d11.10
si:dkeyp-80d11.10
chr11_+_24298432 0.01 ENSDART00000138487
si:dkey-76p14.2
si:dkey-76p14.2
chr4_+_76304911 0.01 ENSDART00000172734
ENSDART00000161850
si:ch73-389k6.1
si:ch73-389k6.1

Network of associatons between targets according to the STRING database.

First level regulatory network of tp73

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 4.6 GO:1904036 negative regulation of epithelial cell apoptotic process(GO:1904036)
0.3 1.4 GO:0033301 cell cycle comprising mitosis without cytokinesis(GO:0033301)
0.3 1.7 GO:0010332 response to gamma radiation(GO:0010332) cellular response to gamma radiation(GO:0071480)
0.3 0.9 GO:0050847 progesterone receptor signaling pathway(GO:0050847)
0.2 2.0 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.2 1.4 GO:0051561 positive regulation of mitochondrial calcium ion concentration(GO:0051561)
0.2 1.2 GO:0007344 karyogamy(GO:0000741) pronuclear fusion(GO:0007344)
0.2 0.7 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway(GO:2001244)
0.2 0.5 GO:0046689 response to mercury ion(GO:0046689) detoxification of mercury ion(GO:0050787)
0.2 0.5 GO:1901503 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) cellular lipid biosynthetic process(GO:0097384) ether biosynthetic process(GO:1901503)
0.1 1.6 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.1 0.7 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway(GO:2001238)
0.1 0.8 GO:0035283 central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.1 0.3 GO:0042779 tRNA 3'-trailer cleavage(GO:0042779)
0.1 0.3 GO:0071072 heat generation(GO:0031649) regulation of heat generation(GO:0031650) positive regulation of heat generation(GO:0031652) regulation of phospholipid biosynthetic process(GO:0071071) negative regulation of phospholipid biosynthetic process(GO:0071072)
0.1 0.3 GO:0006083 acetate metabolic process(GO:0006083) acetyl-CoA biosynthetic process from acetate(GO:0019427)
0.1 0.5 GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902254)
0.0 0.1 GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism(GO:0043903)
0.0 3.2 GO:0035383 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.0 0.7 GO:0018149 peptide cross-linking(GO:0018149)
0.0 1.1 GO:0030199 collagen fibril organization(GO:0030199)
0.0 1.3 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 0.2 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.0 3.3 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 0.4 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.4 GO:0070897 DNA-templated transcriptional preinitiation complex assembly(GO:0070897)
0.0 0.5 GO:0060319 primitive erythrocyte differentiation(GO:0060319)
0.0 0.5 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.4 GO:0070831 basement membrane assembly(GO:0070831)
0.0 0.6 GO:0042129 regulation of T cell proliferation(GO:0042129)
0.0 0.2 GO:0009409 response to cold(GO:0009409)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0032040 small-subunit processome(GO:0032040)
0.1 0.4 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.0 1.3 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.4 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 1.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 1.4 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.6 GO:0035102 PRC1 complex(GO:0035102)
0.0 1.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 6.3 GO:0005730 nucleolus(GO:0005730)
0.0 0.4 GO:0005605 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.0 1.2 GO:0031965 nuclear membrane(GO:0031965)
0.0 0.2 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.5 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.4 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 1.4 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.2 1.4 GO:0001130 bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding(GO:0001130) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217)
0.1 1.6 GO:1990404 protein ADP-ribosylase activity(GO:1990404)
0.1 3.2 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.1 1.5 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.1 0.3 GO:0042781 3'-tRNA processing endoribonuclease activity(GO:0042781)
0.1 0.6 GO:0035613 RNA stem-loop binding(GO:0035613)
0.1 0.5 GO:0019107 myristoyltransferase activity(GO:0019107)
0.1 0.3 GO:0050218 propionate-CoA ligase activity(GO:0050218)
0.1 0.4 GO:0000995 transcription factor activity, core RNA polymerase III binding(GO:0000995)
0.1 1.7 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 0.3 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.5 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.0 0.7 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.4 GO:0016783 sulfurtransferase activity(GO:0016783)
0.0 4.6 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.2 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.0 0.7 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 1.3 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.6 GO:0005518 collagen binding(GO:0005518)
0.0 2.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.7 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.9 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 1.4 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.2 GO:0008301 DNA binding, bending(GO:0008301)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.6 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 0.9 ST STAT3 PATHWAY STAT3 Pathway
0.1 1.7 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.8 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 1.6 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 1.3 PID P53 REGULATION PATHWAY p53 pathway
0.0 0.3 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 1.3 PID E2F PATHWAY E2F transcription factor network
0.0 0.5 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 0.1 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.6 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.3 1.7 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.1 0.9 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 0.3 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.8 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.5 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.5 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.4 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 1.8 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.1 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.5 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions