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PRJEB1986: zebrafish developmental stages transcriptome

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Results for zic4+zic6

Z-value: 1.10

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Transcription factors associated with zic4+zic6

Gene Symbol Gene ID Gene Info
zic4
ENSDARG00000031307 zic family member 4
zic6
ENSDARG00000071496 zic family member 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
zic6dr11_v1_chr14_+_32022272_320222720.977.5e-12Click!
zic4dr11_v1_chr24_+_4977862_49778620.923.3e-08Click!

Activity profile of zic4+zic6 motif

Sorted Z-values of zic4+zic6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr23_+_31933583 5.45 ENSDART00000145639
si:dkey-126g1.9
si:dkey-126g1.9
chr8_+_15269423 5.01 ENSDART00000020386
gclm
glutamate-cysteine ligase, modifier subunit
chr1_-_59571758 4.11 ENSDART00000193546
ENSDART00000167087
wfikkn1
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
chr21_-_21465111 4.06 ENSDART00000141487
nectin3b
nectin cell adhesion molecule 3b
chr13_-_39947335 3.51 ENSDART00000056996
sfrp5
secreted frizzled-related protein 5
chr17_-_4245311 2.74 ENSDART00000055379
gdf3
growth differentiation factor 3
chr18_+_1615 2.59 ENSDART00000082450
homer2
homer scaffolding protein 2
chr21_-_37973819 2.41 ENSDART00000133405
ripply1
ripply transcriptional repressor 1
chr20_-_9980318 2.25 ENSDART00000080664
ACTC1
zgc:86709
chr23_+_44374041 2.11 ENSDART00000136056
ephb4b
eph receptor B4b
chr24_-_34680956 2.04 ENSDART00000171009
ctnna1
catenin (cadherin-associated protein), alpha 1
chr21_-_217589 2.00 ENSDART00000185017
CZQB01146713.1

chr2_-_42628028 1.88 ENSDART00000179866
myo10
myosin X
chr18_-_20458412 1.85 ENSDART00000012241
kif23
kinesin family member 23
chr19_+_35799384 1.84 ENSDART00000076023
angpt2b
angiopoietin 2b
chr12_+_20627164 1.83 ENSDART00000190179
stx4
syntaxin 4
chr12_+_20627505 1.82 ENSDART00000074384
stx4
syntaxin 4
chr17_+_34215886 1.76 ENSDART00000186775
mpp5a
membrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5)
chr8_+_39570615 1.64 ENSDART00000142557
lzts1
leucine zipper, putative tumor suppressor 1
chr6_-_59942335 1.57 ENSDART00000168416
fbxl3b
F-box and leucine-rich repeat protein 3b
chr17_-_4245902 1.54 ENSDART00000151851
gdf3
growth differentiation factor 3
chr12_-_4243268 1.51 ENSDART00000131275
zgc:92313
zgc:92313
chr2_+_15128418 1.46 ENSDART00000141921
arhgap29b
Rho GTPase activating protein 29b
chr14_-_29859067 1.46 ENSDART00000136380
sorbs2b
sorbin and SH3 domain containing 2b
chr25_-_27729046 1.45 ENSDART00000131437
zgc:153935
zgc:153935
chr19_-_17996336 1.44 ENSDART00000186143
ENSDART00000080751
ints8
integrator complex subunit 8
chr17_+_132555 1.42 ENSDART00000158159
zgc:77287
zgc:77287
chr18_-_46354269 1.40 ENSDART00000010813
foxa3
forkhead box A3
chr3_-_40162843 1.37 ENSDART00000129664
ENSDART00000025285
drg2
developmentally regulated GTP binding protein 2
chr20_-_28768109 1.37 ENSDART00000114611
ENSDART00000182443
sipa1l1
signal-induced proliferation-associated 1 like 1
chr16_-_7228276 1.31 ENSDART00000149030
nt5c3a
5'-nucleotidase, cytosolic IIIA
chr25_+_2776511 1.29 ENSDART00000115280
neo1b
neogenin 1b
chr5_+_45007962 1.27 ENSDART00000010786
dmrt2a
doublesex and mab-3 related transcription factor 2a
chr8_+_54284961 1.21 ENSDART00000122692
plxnd1
plexin D1
chr4_+_64562090 1.19 ENSDART00000188810
si:ch211-223a21.3
si:ch211-223a21.3
chr12_-_26851726 1.19 ENSDART00000047724
zeb1b
zinc finger E-box binding homeobox 1b
chr19_-_27550768 1.15 ENSDART00000142313
si:dkeyp-46h3.8
si:dkeyp-46h3.8
chr21_+_5926777 1.13 ENSDART00000121769
rexo4
REX4 homolog, 3'-5' exonuclease
chr11_-_21586157 1.07 ENSDART00000190095
srgap2
SLIT-ROBO Rho GTPase activating protein 2
chr21_-_32289356 1.05 ENSDART00000183050
clk4b
CDC-like kinase 4b
chr5_+_69697800 0.99 ENSDART00000178736
ENSDART00000162519
znf1005
zinc finger protein 1005
chr14_-_21097574 0.99 ENSDART00000186803
rnf20
ring finger protein 20, E3 ubiquitin protein ligase
chr1_+_40613297 0.99 ENSDART00000040798
ENSDART00000168067
ENSDART00000130490
naa15b
N(alpha)-acetyltransferase 15, NatA auxiliary subunit b
chr1_-_34450784 0.98 ENSDART00000140515
lmo7b
LIM domain 7b
chr20_+_26916639 0.95 ENSDART00000077787
serpinb1l2
serpin peptidase inhibitor, clade B (ovalbumin), member 1, like 2
chr10_-_4961923 0.95 ENSDART00000050177
ENSDART00000146066
snx30
sorting nexin family member 30
chr1_-_17711636 0.94 ENSDART00000148322
ENSDART00000122670
ufsp2
ufm1-specific peptidase 2
chr13_-_36534380 0.94 ENSDART00000177857
ENSDART00000181046
ENSDART00000187243
srsf5a
serine/arginine-rich splicing factor 5a
chr25_-_1124851 0.91 ENSDART00000067558
spg11
spastic paraplegia 11
chr5_+_20693724 0.89 ENSDART00000141368
si:ch211-240b21.2
si:ch211-240b21.2
chr1_-_17711361 0.89 ENSDART00000078848
ufsp2
ufm1-specific peptidase 2
chr3_-_19899914 0.86 ENSDART00000134969
rnd2
Rho family GTPase 2
chr24_-_21172122 0.85 ENSDART00000154259
atp6v1ab
ATPase H+ transporting V1 subunit Ab
chr6_+_23026714 0.84 ENSDART00000124948
srp68
signal recognition particle 68
chr5_-_15948833 0.83 ENSDART00000051649
ENSDART00000124467
xbp1
X-box binding protein 1
chr15_+_36941490 0.82 ENSDART00000172664
kirrel3l
kirre like nephrin family adhesion molecule 3, like
chr19_+_40122160 0.81 ENSDART00000143966
si:ch211-173p18.3
si:ch211-173p18.3
chr2_+_15128027 0.79 ENSDART00000016071
arhgap29b
Rho GTPase activating protein 29b
chr18_+_49225552 0.78 ENSDART00000135026
si:ch211-136a13.1
si:ch211-136a13.1
chr14_+_40852497 0.78 ENSDART00000128588
ENSDART00000166065
taf7
TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr17_+_28670132 0.78 ENSDART00000076344
ENSDART00000164981
ENSDART00000182851
hectd1
HECT domain containing 1
chr18_-_50947868 0.76 ENSDART00000174276
st7
suppression of tumorigenicity 7
chr19_-_81851 0.74 ENSDART00000172319
hnrnpr
heterogeneous nuclear ribonucleoprotein R
chr11_-_20956309 0.71 ENSDART00000188659
CABZ01008739.1

chr1_-_34450622 0.70 ENSDART00000083736
lmo7b
LIM domain 7b
chr20_-_14781904 0.66 ENSDART00000187200
ENSDART00000179912
ENSDART00000160481
ENSDART00000026969
suco
SUN domain containing ossification factor
chr21_-_14664445 0.65 ENSDART00000124223
ehmt1b
euchromatic histone-lysine N-methyltransferase 1b
chr20_-_28642061 0.64 ENSDART00000135513
rgs6
regulator of G protein signaling 6
chr11_-_6070192 0.64 ENSDART00000162776
babam1
BRISC and BRCA1 A complex member 1
chr23_+_9353552 0.62 ENSDART00000163298
BX511246.1

chr19_-_17996162 0.62 ENSDART00000150928
ENSDART00000104491
ints8
integrator complex subunit 8
chr8_+_12925385 0.61 ENSDART00000085377
KIF2A
zgc:103670
chr11_+_31558006 0.61 ENSDART00000024296
egln1b
egl-9 family hypoxia-inducible factor 1b
chr11_+_34921492 0.60 ENSDART00000128070
gnai2a
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2a
chr8_-_1266181 0.58 ENSDART00000148654
ENSDART00000149924
cdc14b
cell division cycle 14B
chr14_+_790166 0.58 ENSDART00000123912
adra2da
adrenergic, alpha-2D-, receptor a
chr5_+_37744625 0.57 ENSDART00000014031
dpf2
D4, zinc and double PHD fingers family 2
chr1_+_49652967 0.56 ENSDART00000191296
tsga10
testis specific, 10
chr9_+_23124252 0.54 ENSDART00000192377
BX936418.1

chr9_-_37748513 0.53 ENSDART00000188967
ENSDART00000187886
sema5ba
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5Ba
chr5_-_61588998 0.49 ENSDART00000050912
pex12
peroxisomal biogenesis factor 12
chr18_+_31117136 0.48 ENSDART00000138403
tcf25
transcription factor 25 (basic helix-loop-helix)
chr16_-_46567344 0.45 ENSDART00000127721
si:dkey-152b24.7
si:dkey-152b24.7
chr17_-_23895026 0.42 ENSDART00000122108
pdzd8
PDZ domain containing 8
chr11_-_2504750 0.40 ENSDART00000173149
dgkab
diacylglycerol kinase, alpha b
chr23_-_18982499 0.39 ENSDART00000012507
bcl2l1
bcl2-like 1
chr12_-_41619257 0.35 ENSDART00000162967
dpysl4
dihydropyrimidinase-like 4
chr23_+_7471072 0.33 ENSDART00000135551
si:ch211-200e2.1
si:ch211-200e2.1
chr3_-_25814097 0.30 ENSDART00000169706
ntn1b
netrin 1b
chr25_-_3087556 0.29 ENSDART00000193249
best1
bestrophin 1
chr16_-_55028740 0.29 ENSDART00000156368
ENSDART00000161704
zgc:114181
zgc:114181
chr11_-_44999858 0.26 ENSDART00000167759
ENSDART00000126845
ldb1b
LIM-domain binding 1b
chr9_-_32191620 0.26 ENSDART00000139426
pimr143
Pim proto-oncogene, serine/threonine kinase, related 143
chr15_-_33495048 0.24 ENSDART00000159882
stard13b
StAR-related lipid transfer (START) domain containing 13b
chr8_+_7033049 0.23 ENSDART00000064172
ENSDART00000134440
gpd1a
glycerol-3-phosphate dehydrogenase 1a
chr1_-_58601636 0.22 ENSDART00000141143
si:ch73-236c18.8
si:ch73-236c18.8
chr16_-_37964325 0.21 ENSDART00000148801
mrap2a
melanocortin 2 receptor accessory protein 2a
chr8_-_7851590 0.20 ENSDART00000160692
zgc:113363
zgc:113363
chr12_-_2800809 0.18 ENSDART00000152682
ENSDART00000083784
ubtd1b
ubiquitin domain containing 1b
chr3_+_24094581 0.17 ENSDART00000138270
ENSDART00000131509
copz2
coatomer protein complex, subunit zeta 2
chr11_-_22605981 0.17 ENSDART00000186923
myog
myogenin
chr12_-_4206869 0.17 ENSDART00000106572
si:dkey-32n7.9
si:dkey-32n7.9
chr4_-_10958074 0.16 ENSDART00000150478
si:ch211-161n3.4
si:ch211-161n3.4
chr5_+_31811662 0.16 ENSDART00000023463
uap1l1
UDP-N-acetylglucosamine pyrophosphorylase 1, like 1
chr6_-_426041 0.15 ENSDART00000162789
fam83fb
family with sequence similarity 83, member Fb
chr8_+_40210398 0.14 ENSDART00000167612
rnf34a
ring finger protein 34a
chr5_+_30596822 0.13 ENSDART00000188375
hinfp
histone H4 transcription factor
chr19_+_42983613 0.13 ENSDART00000033724
fabp3
fatty acid binding protein 3, muscle and heart
chr8_-_4618653 0.13 ENSDART00000025535
sept5a
septin 5a
chr23_+_24705424 0.13 ENSDART00000104029
c1qtnf12
C1q and TNF related 12
chr25_-_18730697 0.12 ENSDART00000182475
si:dkeyp-93a5.2
si:dkeyp-93a5.2
chr2_-_58919975 0.12 ENSDART00000114286
sugp1
SURP and G patch domain containing 1
chr10_+_40737540 0.11 ENSDART00000125577
taar19a
trace amine associated receptor 19a
chr6_-_7438584 0.11 ENSDART00000053776
fkbp11
FK506 binding protein 11
chr3_-_19561058 0.11 ENSDART00000079323
zgc:163079
zgc:163079
chr17_+_1499238 0.11 ENSDART00000187561
LO018430.1

chr2_+_36004381 0.06 ENSDART00000098706
lamc2
laminin, gamma 2
chr15_-_38202630 0.04 ENSDART00000183772
rhoga
ras homolog family member Ga
chr23_-_29824146 0.04 ENSDART00000020616
zgc:194189
zgc:194189
chr2_-_14987282 0.03 ENSDART00000143057
hccsa.2
holocytochrome c synthase a, tandem duplicate 2

Network of associatons between targets according to the STRING database.

First level regulatory network of zic4+zic6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.0 GO:0006750 glutathione biosynthetic process(GO:0006750)
1.2 3.5 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
0.9 4.3 GO:1900145 nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145)
0.7 2.2 GO:0048785 hatching gland development(GO:0048785)
0.5 1.8 GO:0048014 Tie signaling pathway(GO:0048014)
0.4 1.8 GO:0016332 establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
0.3 2.6 GO:0021553 olfactory nerve development(GO:0021553) olfactory nerve morphogenesis(GO:0021627) olfactory nerve formation(GO:0021628)
0.3 1.8 GO:0040016 embryonic cleavage(GO:0040016)
0.2 1.2 GO:0070587 regulation of cell-cell adhesion involved in gastrulation(GO:0070587)
0.2 1.1 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.2 1.1 GO:2001223 negative regulation of neuron migration(GO:2001223)
0.2 2.4 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
0.1 1.0 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.1 4.1 GO:0007286 spermatid development(GO:0007286)
0.1 0.6 GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway(GO:0071881)
0.1 3.7 GO:0099500 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.1 0.3 GO:0021960 anterior commissure morphogenesis(GO:0021960)
0.1 3.0 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
0.1 0.4 GO:0051659 maintenance of mitochondrion location(GO:0051659)
0.1 0.6 GO:0072425 signal transduction involved in DNA integrity checkpoint(GO:0072401) signal transduction involved in DNA damage checkpoint(GO:0072422) signal transduction involved in G2 DNA damage checkpoint(GO:0072425)
0.1 2.1 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.1 1.6 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.1 0.7 GO:0046850 regulation of bone remodeling(GO:0046850)
0.1 0.8 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.1 0.2 GO:0046168 NADH oxidation(GO:0006116) glycerol-3-phosphate catabolic process(GO:0046168)
0.1 0.6 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.1 1.2 GO:1902287 semaphorin-plexin signaling pathway involved in neuron projection guidance(GO:1902285) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)
0.1 0.6 GO:0035588 adenosine receptor signaling pathway(GO:0001973) purinergic receptor signaling pathway(GO:0035587) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.1 0.5 GO:0050975 sensory perception of touch(GO:0050975)
0.0 0.8 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 5.6 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.0 1.5 GO:0006513 protein monoubiquitination(GO:0006513)
0.0 1.3 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 1.0 GO:0007520 myoblast fusion(GO:0007520)
0.0 0.9 GO:0001966 thigmotaxis(GO:0001966)
0.0 1.9 GO:0099515 vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.0 1.3 GO:0007548 sex differentiation(GO:0007548)
0.0 0.1 GO:0046324 regulation of glucose import(GO:0046324)
0.0 0.2 GO:0046070 dGTP catabolic process(GO:0006203) purine nucleoside triphosphate catabolic process(GO:0009146) purine deoxyribonucleoside triphosphate catabolic process(GO:0009217) dGTP metabolic process(GO:0046070)
0.0 0.2 GO:0034394 protein localization to cell surface(GO:0034394)
0.0 2.0 GO:0001894 tissue homeostasis(GO:0001894)
0.0 2.1 GO:0070121 Kupffer's vesicle development(GO:0070121)
0.0 0.4 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208)
0.0 0.8 GO:0070534 protein K63-linked ubiquitination(GO:0070534)
0.0 2.3 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.4 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 1.4 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 0.3 GO:0019471 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471)
0.0 0.2 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0 1.8 GO:0001947 heart looping(GO:0001947)
0.0 0.9 GO:1902600 hydrogen ion transmembrane transport(GO:1902600)
0.0 0.9 GO:0030865 cortical cytoskeleton organization(GO:0030865)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0031415 NatA complex(GO:0031415)
0.2 0.5 GO:1990415 Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429)
0.2 3.7 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.1 0.8 GO:0048500 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.1 2.0 GO:0030057 desmosome(GO:0030057)
0.1 0.4 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.1 2.1 GO:0032039 integrator complex(GO:0032039)
0.1 1.8 GO:0001917 photoreceptor inner segment(GO:0001917)
0.1 0.6 GO:0070552 BRISC complex(GO:0070552)
0.1 1.2 GO:0002116 semaphorin receptor complex(GO:0002116)
0.1 0.9 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 1.1 GO:0044327 dendritic spine head(GO:0044327) phagocytic vesicle(GO:0045335)
0.0 1.8 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.2 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0 0.8 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 4.1 GO:0043296 apical junction complex(GO:0043296)
0.0 0.6 GO:0071565 nBAF complex(GO:0071565)
0.0 1.6 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.9 GO:0016459 myosin complex(GO:0016459)
0.0 0.2 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.9 GO:0044309 dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.0 1.5 GO:0005925 focal adhesion(GO:0005925)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.1 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.2 0.8 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.2 0.5 GO:0008022 protein C-terminus binding(GO:0008022)
0.1 3.5 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 0.6 GO:0004938 alpha2-adrenergic receptor activity(GO:0004938)
0.1 2.1 GO:0005003 ephrin receptor activity(GO:0005003)
0.1 0.9 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 1.0 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.1 1.3 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.1 0.2 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.1 1.8 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.1 3.7 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 0.2 GO:0031781 type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.0 1.1 GO:0031267 small GTPase binding(GO:0031267)
0.0 0.7 GO:0002039 p53 binding(GO:0002039)
0.0 2.0 GO:0008013 beta-catenin binding(GO:0008013)
0.0 1.2 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.8 GO:0016251 obsolete general RNA polymerase II transcription factor activity(GO:0016251)
0.0 0.3 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.2 GO:0016793 dGTPase activity(GO:0008832) triphosphoric monoester hydrolase activity(GO:0016793)
0.0 4.5 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 1.9 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 1.8 GO:0016790 thiolester hydrolase activity(GO:0016790)
0.0 0.2 GO:0003977 UDP-N-acetylglucosamine diphosphorylase activity(GO:0003977)
0.0 0.4 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.3 GO:0016805 dipeptidase activity(GO:0016805)
0.0 5.0 GO:0016874 ligase activity(GO:0016874)
0.0 0.6 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 1.1 GO:0008408 3'-5' exonuclease activity(GO:0008408)
0.0 0.4 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 1.8 GO:0003777 microtubule motor activity(GO:0003777)
0.0 2.6 GO:0008083 growth factor activity(GO:0008083)
0.0 0.9 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.3 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 4.5 GO:0005096 GTPase activator activity(GO:0005096)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.7 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.1 2.0 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.1 1.9 PID NETRIN PATHWAY Netrin-mediated signaling events
0.1 11.9 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.1 2.2 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 1.8 PID AURORA B PATHWAY Aurora B signaling
0.0 0.4 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.2 PID PLK1 PATHWAY PLK1 signaling events
0.0 1.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 5.0 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.2 3.7 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 2.5 REACTOME KINESINS Genes involved in Kinesins
0.1 1.6 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.1 0.8 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 2.0 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 1.4 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.1 1.2 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 0.4 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.1 1.9 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.4 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 1.1 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor