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PRJNA195909:zebrafish embryo and larva development

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Results for atf4a+atf4b

Z-value: 0.68

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Transcription factors associated with atf4a+atf4b

Gene Symbol Gene ID Gene Info
atf4b
ENSDARG00000038141 activating transcription factor 4b
atf4a
ENSDARG00000111939 activating transcription factor 4a
atf4b
ENSDARG00000114163 activating transcription factor 4b
atf4b
ENSDARG00000114542 activating transcription factor 4b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
atf4adr11_v1_chr6_+_269204_269204-0.925.3e-04Click!
atf4bdr11_v1_chr3_+_24197934_24197934-0.901.0e-03Click!

Activity profile of atf4a+atf4b motif

Sorted Z-values of atf4a+atf4b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr23_-_18030399 1.21 ENSDART00000136967
pm20d1.1
peptidase M20 domain containing 1, tandem duplicate 1
chr8_+_42917515 1.14 ENSDART00000021715
slc23a2
solute carrier family 23 (ascorbic acid transporter), member 2
chr7_+_38090515 1.12 ENSDART00000131387
cebpg
CCAAT/enhancer binding protein (C/EBP), gamma
chr6_+_28428329 0.99 ENSDART00000188056
lpp
LIM domain containing preferred translocation partner in lipoma
chr12_+_30789611 0.97 ENSDART00000181501
aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr12_+_30788912 0.95 ENSDART00000160422
aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr14_-_7306983 0.88 ENSDART00000158914
si:ch211-51f19.1
si:ch211-51f19.1
chr20_+_28266892 0.83 ENSDART00000103330
chac1
ChaC, cation transport regulator homolog 1 (E. coli)
chr18_-_21047007 0.81 ENSDART00000162702
igf1ra
insulin-like growth factor 1a receptor
chr12_+_17154655 0.81 ENSDART00000028003
ankrd22
ankyrin repeat domain 22
chr24_-_26854032 0.79 ENSDART00000087991
fndc3bb
fibronectin type III domain containing 3Bb
chr6_+_37754763 0.76 ENSDART00000110770
herc2
HECT and RLD domain containing E3 ubiquitin protein ligase 2
chr11_+_45287541 0.76 ENSDART00000165321
ENSDART00000173116
pycr1b
pyrroline-5-carboxylate reductase 1b
chr13_-_20540790 0.74 ENSDART00000131467
si:ch1073-126c3.2
si:ch1073-126c3.2
chr8_+_7778770 0.74 ENSDART00000171325
tfe3a
transcription factor binding to IGHM enhancer 3a
chr13_-_25408387 0.73 ENSDART00000002741
itprip
inositol 1,4,5-trisphosphate receptor interacting protein
chr19_-_8812891 0.73 ENSDART00000151134
ENSDART00000025385
ENSDART00000180291
cers2a
ceramide synthase 2a
chr3_+_15394428 0.71 ENSDART00000133168
atxn2l
ataxin 2-like
chr16_-_42770064 0.65 ENSDART00000112879
slc4a7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr20_+_37794633 0.63 ENSDART00000022060
atf3
activating transcription factor 3
chr3_+_25907266 0.62 ENSDART00000170324
ENSDART00000192633
tom1
target of myb1 membrane trafficking protein
chr5_+_57658898 0.62 ENSDART00000074268
ENSDART00000124568
zgc:153929
zgc:153929
chr12_-_35386910 0.61 ENSDART00000153453
camk2g1
calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1
chr20_-_32007209 0.61 ENSDART00000021575
adgb
androglobin
chr14_-_30945515 0.59 ENSDART00000161540
si:zfos-80g12.1
si:zfos-80g12.1
chr15_-_24960730 0.59 ENSDART00000109990
ENSDART00000186706
abhd15a
abhydrolase domain containing 15a
chr24_-_38644937 0.59 ENSDART00000170194
slc6a16b
solute carrier family 6, member 16b
chr23_+_32101361 0.59 ENSDART00000138849
zgc:56699
zgc:56699
chr12_-_32066469 0.58 ENSDART00000140685
ENSDART00000062185
rab40b
RAB40B, member RAS oncogene family
chr19_+_43341424 0.58 ENSDART00000134815
sesn2
sestrin 2
chr15_+_45994123 0.57 ENSDART00000124704
lrfn1
leucine rich repeat and fibronectin type III domain containing 1
chr5_-_69523816 0.56 ENSDART00000112692
si:ch211-157p22.10
si:ch211-157p22.10
chr19_+_43341115 0.54 ENSDART00000145846
ENSDART00000102384
sesn2
sestrin 2
chr17_-_42799104 0.52 ENSDART00000154755
prkd3
protein kinase D3
chr3_+_33440615 0.51 ENSDART00000146005
gtpbp1
GTP binding protein 1
chr18_+_17600570 0.50 ENSDART00000175258
ENSDART00000151850
ENSDART00000151934
herpud1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr15_-_7337148 0.49 ENSDART00000182568
SLC7A1 (1 of many)
high affinity cationic amino acid transporter 1
chr1_+_37312580 0.49 ENSDART00000171340
fam193a
family with sequence similarity 193, member A
chr12_-_48374728 0.49 ENSDART00000153403
ENSDART00000188117
dnajb12b
DnaJ (Hsp40) homolog, subfamily B, member 12b
chr18_+_17493859 0.46 ENSDART00000090754
si:dkey-102f14.5
si:dkey-102f14.5
chr22_+_38276024 0.43 ENSDART00000143792
rcor3
REST corepressor 3
chr15_-_23908779 0.42 ENSDART00000088808
usp32
ubiquitin specific peptidase 32
chr14_-_26465729 0.42 ENSDART00000143454
syvn1
synovial apoptosis inhibitor 1, synoviolin
chr2_+_16597011 0.42 ENSDART00000160641
ENSDART00000125413
xrn1
5'-3' exoribonuclease 1
chr12_+_46960579 0.42 ENSDART00000149032
oat
ornithine aminotransferase
chr25_-_21894706 0.41 ENSDART00000189158
fbxo31
F-box protein 31
chr15_-_23908605 0.41 ENSDART00000185578
usp32
ubiquitin specific peptidase 32
chr10_-_8672820 0.39 ENSDART00000080763
si:dkey-27b3.2
si:dkey-27b3.2
chr5_-_35200590 0.38 ENSDART00000051271
fcho2
FCH domain only 2
chr23_-_26228077 0.38 ENSDART00000162423
BX927204.1

chr25_-_21894317 0.38 ENSDART00000089642
fbxo31
F-box protein 31
chr22_+_25931782 0.37 ENSDART00000157842
dnaja3b
DnaJ (Hsp40) homolog, subfamily A, member 3B
chr24_+_32525146 0.37 ENSDART00000132417
ENSDART00000110185
yme1l1a
YME1-like 1a
chr20_-_20611063 0.36 ENSDART00000063492
ppm1ab
protein phosphatase, Mg2+/Mn2+ dependent, 1Ab
chr20_+_21583639 0.35 ENSDART00000131069
esr2a
estrogen receptor 2a
chr21_+_30721733 0.34 ENSDART00000040443
zgc:110224
zgc:110224
chr7_-_32981559 0.34 ENSDART00000175614
pkp3b
plakophilin 3b
chr20_-_38746889 0.34 ENSDART00000140275
trim54
tripartite motif containing 54
chr12_-_17602958 0.34 ENSDART00000134690
ENSDART00000028090
eif2ak1
eukaryotic translation initiation factor 2-alpha kinase 1
chr21_-_36571804 0.33 ENSDART00000138129
wwc1
WW and C2 domain containing 1
chr14_-_23801389 0.32 ENSDART00000054264
nr3c1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr6_+_49551614 0.31 ENSDART00000022581
rab22a
RAB22A, member RAS oncogene family
chr12_+_17603528 0.31 ENSDART00000111565
pms2
PMS1 homolog 2, mismatch repair system component
chr21_-_36948 0.31 ENSDART00000181230
JMY
junction mediating and regulatory protein, p53 cofactor
chr14_+_7892021 0.31 ENSDART00000161307
ube2d2
ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)
chr16_+_10429770 0.31 ENSDART00000173132
vars
valyl-tRNA synthetase
chr8_-_31384607 0.30 ENSDART00000164134
ENSDART00000024872
creb3l3l
cAMP responsive element binding protein 3-like 3 like
chr24_-_39771667 0.30 ENSDART00000181867
GFOD1
si:ch211-276f18.2
chr16_-_31351419 0.30 ENSDART00000178298
ENSDART00000018091
mroh1
maestro heat-like repeat family member 1
chr18_-_2727764 0.29 ENSDART00000160841
ARHGEF17
si:ch211-248g20.5
chr6_-_9707599 0.29 ENSDART00000039280
fzd7b
frizzled class receptor 7b
chr3_-_30153242 0.28 ENSDART00000077089
nucb1
nucleobindin 1
chr2_+_35240764 0.27 ENSDART00000015827
tnr
tenascin R (restrictin, janusin)
chr2_-_28671139 0.27 ENSDART00000165272
ENSDART00000164657
dhcr7
7-dehydrocholesterol reductase
chr23_-_26227805 0.27 ENSDART00000158082
BX927204.1

chr14_-_47882706 0.26 ENSDART00000188772
rapgef2
Rap guanine nucleotide exchange factor (GEF) 2
chr19_+_30884960 0.26 ENSDART00000140603
ENSDART00000183224
ENSDART00000135484
ENSDART00000139599
yars
tyrosyl-tRNA synthetase
chr20_+_28803977 0.25 ENSDART00000153351
ENSDART00000038149
fntb
farnesyltransferase, CAAX box, beta
chr3_-_30152836 0.25 ENSDART00000165920
nucb1
nucleobindin 1
chr7_+_39664055 0.25 ENSDART00000146171
zgc:158564
zgc:158564
chr20_-_14680897 0.24 ENSDART00000063857
ENSDART00000161314
scrn2
secernin 2
chr13_-_25548733 0.24 ENSDART00000168099
ENSDART00000135788
ENSDART00000077655
mcmbp
minichromosome maintenance complex binding protein
chr9_+_24088062 0.23 ENSDART00000126198
lrrfip1a
leucine rich repeat (in FLII) interacting protein 1a
chr3_+_32868092 0.21 ENSDART00000137668
zgc:162613
zgc:162613
chr25_-_6389713 0.20 ENSDART00000083539
sin3aa
SIN3 transcription regulator family member Aa
chr16_+_4839078 0.20 ENSDART00000150111
ibtk
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr3_+_19216567 0.20 ENSDART00000134433
il12rb2l
interleukin 12 receptor, beta 2a, like
chr21_-_11646878 0.19 ENSDART00000162426
ENSDART00000135937
ENSDART00000131448
ENSDART00000148097
ENSDART00000133443
cast
calpastatin
chr4_+_16784553 0.19 ENSDART00000134054
si:dkey-13i19.8
si:dkey-13i19.8
chr7_-_30272871 0.19 ENSDART00000099586
zgc:162945
zgc:162945
chr12_-_13205572 0.19 ENSDART00000152670
pelo
pelota mRNA surveillance and ribosome rescue factor
chr19_-_3876877 0.19 ENSDART00000163711
thrap3b
thyroid hormone receptor associated protein 3b
chr16_-_36093776 0.18 ENSDART00000159134
OSCP1
organic solute carrier partner 1
chr13_+_21600946 0.18 ENSDART00000144045
sh2d4ba
SH2 domain containing 4Ba
chr6_-_58975010 0.18 ENSDART00000144911
ENSDART00000144514
mars
methionyl-tRNA synthetase
chr12_+_34953038 0.18 ENSDART00000187022
ENSDART00000123988
ENSDART00000027034
qki2
QKI, KH domain containing, RNA binding 2
chr25_-_25550938 0.17 ENSDART00000150412
ENSDART00000103622
irf7
interferon regulatory factor 7
chr18_+_2228737 0.17 ENSDART00000165301
rab27a
RAB27A, member RAS oncogene family
chr3_-_15889508 0.17 ENSDART00000148363
cramp1
cramped chromatin regulator homolog 1
chr16_+_27442549 0.16 ENSDART00000015688
invs
inversin
chr13_-_25774183 0.16 ENSDART00000046981
pdlim1
PDZ and LIM domain 1 (elfin)
chr15_+_20543770 0.16 ENSDART00000092357
sgsm2
small G protein signaling modulator 2
chr15_+_24737599 0.15 ENSDART00000078024
crk
v-crk avian sarcoma virus CT10 oncogene homolog
chr4_-_17642168 0.15 ENSDART00000007030
klhl42
kelch-like family, member 42
chr7_-_16034324 0.15 ENSDART00000002498
ENSDART00000162962
elp4
elongator acetyltransferase complex subunit 4
chr16_-_13818061 0.15 ENSDART00000132982
ENSDART00000144856
leng9
leukocyte receptor cluster (LRC) member 9
chr19_+_30885258 0.15 ENSDART00000143394
yars
tyrosyl-tRNA synthetase
chr17_-_50220228 0.14 ENSDART00000058707
jdp2a
Jun dimerization protein 2a
chr16_+_4838808 0.14 ENSDART00000179363
ibtk
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr20_-_20610812 0.13 ENSDART00000181870
ppm1ab
protein phosphatase, Mg2+/Mn2+ dependent, 1Ab
chr13_+_21601149 0.12 ENSDART00000179369
sh2d4ba
SH2 domain containing 4Ba
chr19_+_30884706 0.12 ENSDART00000052126
yars
tyrosyl-tRNA synthetase
chr16_-_20006270 0.12 ENSDART00000079155
hdac9b
histone deacetylase 9b
chr15_-_31409013 0.12 ENSDART00000140456
or111-9
odorant receptor, family D, subfamily 111, member 9
chr13_-_9300299 0.12 ENSDART00000144142
HTRA2 (1 of many)
si:dkey-33c12.12
chr18_-_18667416 0.11 ENSDART00000100401
ENSDART00000136544
aars
alanyl-tRNA synthetase
chr3_+_1107102 0.10 ENSDART00000092690
srebf2
sterol regulatory element binding transcription factor 2
chr23_+_43718115 0.10 ENSDART00000149266
ENSDART00000149503
anapc10
anaphase promoting complex subunit 10
chr25_+_26923193 0.09 ENSDART00000187364
grm8b
glutamate receptor, metabotropic 8b
chr2_-_32486080 0.09 ENSDART00000110821
ttc19
tetratricopeptide repeat domain 19
chr18_-_17399291 0.09 ENSDART00000192075
ENSDART00000060949
ENSDART00000188506
zfpm1
zinc finger protein, FOG family member 1
chr24_-_37484123 0.09 ENSDART00000111623
cluap1
clusterin associated protein 1
chr15_-_25392589 0.09 ENSDART00000124205
si:dkey-54n8.4
si:dkey-54n8.4
chr18_+_26719787 0.09 ENSDART00000141672
alpk3a
alpha-kinase 3a
chr7_+_49862837 0.08 ENSDART00000174315
slc1a2a
solute carrier family 1 (glial high affinity glutamate transporter), member 2a
chr3_-_43835055 0.07 ENSDART00000165592
rmi2
RecQ mediated genome instability 2
chr6_+_48862 0.06 ENSDART00000082954
mbd5
methyl-CpG binding domain protein 5
chr7_-_31830936 0.06 ENSDART00000052514
ENSDART00000129720
cars
cysteinyl-tRNA synthetase
chr8_+_54202554 0.06 ENSDART00000020569
creld1b
cysteine-rich with EGF-like domains 1b
chr23_-_36441693 0.06 ENSDART00000024354
csad
cysteine sulfinic acid decarboxylase
chr16_+_25245857 0.05 ENSDART00000155220
klhl38b
kelch-like family member 38b
chr9_+_747612 0.05 ENSDART00000181004
insig2
insulin induced gene 2
chr6_+_41255485 0.05 ENSDART00000042683
ENSDART00000186013
cadpsb
Ca2+-dependent activator protein for secretion b
chr16_+_40024883 0.04 ENSDART00000110100
hint3
histidine triad nucleotide binding protein 3
chr12_+_6065661 0.04 ENSDART00000142418
sgms1
sphingomyelin synthase 1
chr12_+_13205955 0.04 ENSDART00000092906
ppp1cab
protein phosphatase 1, catalytic subunit, alpha isozyme b
chr2_+_1001560 0.04 ENSDART00000134656
cacna1eb
calcium channel, voltage-dependent, R type, alpha 1E subunit b
chr15_-_2754056 0.04 ENSDART00000129380
ppp5c
protein phosphatase 5, catalytic subunit
chr3_-_40284744 0.04 ENSDART00000018626
pdap1b
pdgfa associated protein 1b
chr8_-_46386024 0.03 ENSDART00000136602
ENSDART00000060919
ENSDART00000137472
qars
glutaminyl-tRNA synthetase
chr6_+_23809501 0.03 ENSDART00000168701
glulb
glutamate-ammonia ligase (glutamine synthase) b
chr12_-_46959990 0.03 ENSDART00000084557
lhpp
phospholysine phosphohistidine inorganic pyrophosphate phosphatase
chr25_+_28893615 0.02 ENSDART00000156994
ENSDART00000075151
amn1
antagonist of mitotic exit network 1 homolog (S. cerevisiae)
chr9_-_46415847 0.02 ENSDART00000009790
cx43.4
connexin 43.4
chr16_+_33143503 0.02 ENSDART00000058471
ENSDART00000179385
rhbdl2
rhomboid, veinlet-like 2 (Drosophila)
chr23_-_29394505 0.02 ENSDART00000017728
pgd
phosphogluconate dehydrogenase
chr8_-_11170114 0.02 ENSDART00000133532
si:ch211-204d2.4
si:ch211-204d2.4
chr3_+_25191467 0.02 ENSDART00000156956
ENSDART00000154799
il2rb
interleukin 2 receptor, beta
chr2_-_20890429 0.02 ENSDART00000149989
pdca
phosducin a
chr21_-_43949208 0.02 ENSDART00000150983
camk2a
calcium/calmodulin-dependent protein kinase II alpha
chr8_-_25729542 0.01 ENSDART00000078149
ENSDART00000085779
foxp3a
forkhead box P3a
chr18_+_27926839 0.01 ENSDART00000191835
hipk3b
homeodomain interacting protein kinase 3b
chr14_-_38809561 0.01 ENSDART00000159159
sil1
SIL1 nucleotide exchange factor
chr1_-_11519934 0.00 ENSDART00000162060
sdk1b
sidekick cell adhesion molecule 1b
chr23_+_35504824 0.00 ENSDART00000082647
ENSDART00000159218
acp1
acid phosphatase 1
chr25_-_6049339 0.00 ENSDART00000075184
snx1a
sorting nexin 1a

Network of associatons between targets according to the STRING database.

First level regulatory network of atf4a+atf4b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0019852 L-ascorbic acid transport(GO:0015882) L-ascorbic acid metabolic process(GO:0019852)
0.3 3.1 GO:0006561 proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
0.3 1.2 GO:2000275 regulation of oxidative phosphorylation uncoupler activity(GO:2000275)
0.2 1.7 GO:0043201 response to leucine(GO:0043201) cellular response to leucine(GO:0071233) regulation of response to reactive oxygen species(GO:1901031)
0.2 0.5 GO:1903069 regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903069)
0.2 0.8 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)
0.1 0.7 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.1 0.8 GO:0006751 glutathione catabolic process(GO:0006751)
0.1 0.5 GO:0089700 protein kinase D signaling(GO:0089700)
0.1 0.3 GO:0071387 cellular response to cortisol stimulus(GO:0071387)
0.1 0.3 GO:0000012 single strand break repair(GO:0000012)
0.1 0.3 GO:0018343 protein farnesylation(GO:0018343)
0.1 0.2 GO:1901533 negative regulation of hematopoietic progenitor cell differentiation(GO:1901533)
0.1 0.7 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.1 0.8 GO:0048009 insulin-like growth factor receptor signaling pathway(GO:0048009)
0.0 0.3 GO:0032475 otolith formation(GO:0032475)
0.0 0.2 GO:0072003 kidney rudiment formation(GO:0072003) pronephros formation(GO:0072116)
0.0 0.4 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.0 0.3 GO:0030520 intracellular estrogen receptor signaling pathway(GO:0030520) cellular response to estradiol stimulus(GO:0071392)
0.0 0.5 GO:0016075 rRNA catabolic process(GO:0016075)
0.0 1.0 GO:0060030 dorsal convergence(GO:0060030)
0.0 0.7 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.2 GO:0097340 inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341)
0.0 0.5 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.0 0.5 GO:0071218 response to misfolded protein(GO:0051788) cellular response to misfolded protein(GO:0071218)
0.0 0.5 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 0.1 GO:0030219 megakaryocyte differentiation(GO:0030219)
0.0 0.1 GO:0031063 regulation of histone deacetylation(GO:0031063)
0.0 0.0 GO:0036315 response to sterol(GO:0036314) cellular response to sterol(GO:0036315) SREBP-SCAP complex retention in endoplasmic reticulum(GO:0036316) regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.0 0.6 GO:0072114 pronephros morphogenesis(GO:0072114)
0.0 0.1 GO:0097033 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0 0.8 GO:0016575 histone deacetylation(GO:0016575)
0.0 0.1 GO:0043570 maintenance of DNA repeat elements(GO:0043570)
0.0 0.4 GO:0009408 response to heat(GO:0009408)
0.0 0.3 GO:0006298 mismatch repair(GO:0006298)
0.0 0.4 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.8 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 0.3 GO:0042446 hormone biosynthetic process(GO:0042446)
0.0 0.1 GO:0010885 regulation of cholesterol storage(GO:0010885)
0.0 0.3 GO:0045879 negative regulation of smoothened signaling pathway(GO:0045879)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.7 GO:0061700 GATOR2 complex(GO:0061700)
0.2 0.8 GO:0005899 insulin receptor complex(GO:0005899)
0.1 0.4 GO:0000836 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.1 0.3 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.0 0.7 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.3 GO:0032300 mismatch repair complex(GO:0032300)
0.0 0.1 GO:0044316 cone cell pedicle(GO:0044316)
0.0 1.2 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.1 GO:0010369 chromocenter(GO:0010369)
0.0 0.7 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.3 GO:0030057 desmosome(GO:0030057)
0.0 0.2 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.0 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.2 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.2 GO:0042555 MCM complex(GO:0042555)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.9 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.2 1.7 GO:0070728 leucine binding(GO:0070728)
0.2 0.8 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.2 0.8 GO:0005009 insulin-activated receptor activity(GO:0005009) insulin receptor substrate binding(GO:0043560)
0.2 0.8 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.1 1.2 GO:0004046 aminoacylase activity(GO:0004046)
0.1 0.4 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.1 0.6 GO:0034338 short-chain carboxylesterase activity(GO:0034338)
0.1 0.8 GO:0030332 cyclin binding(GO:0030332)
0.1 0.3 GO:0004660 protein farnesyltransferase activity(GO:0004660)
0.1 0.3 GO:1903924 estradiol binding(GO:1903924)
0.0 0.7 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.2 GO:0070004 cysteine-type exopeptidase activity(GO:0070004)
0.0 0.7 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.4 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.0 0.5 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 0.2 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.0 0.6 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.5 GO:0004697 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.0 0.3 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.3 GO:0030983 mismatched DNA binding(GO:0030983)
0.0 0.1 GO:0001642 group III metabotropic glutamate receptor activity(GO:0001642)
0.0 0.6 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.3 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.2 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 1.0 PID AP1 PATHWAY AP-1 transcription factor network
0.0 0.7 PID CMYB PATHWAY C-MYB transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.9 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.3 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.4 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0 0.8 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 1.1 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.3 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.2 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.0 0.2 REACTOME ARMS MEDIATED ACTIVATION Genes involved in ARMS-mediated activation
0.0 0.3 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.3 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis