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PRJNA195909:zebrafish embryo and larva development

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Results for bhlha15_bhlhe23+si:ch211-196c10.13_bhlhe22

Z-value: 1.91

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Transcription factors associated with bhlha15_bhlhe23+si:ch211-196c10.13_bhlhe22

Gene Symbol Gene ID Gene Info
bhlha15
ENSDARG00000045166 basic helix-loop-helix family, member a15
bhlhe23
ENSDARG00000037588 basic helix-loop-helix family, member e23
si_ch211-196c10.13
ENSDARG00000096756 si_ch211-196c10.13
bhlhe22
ENSDARG00000058039 basic helix-loop-helix family, member e22

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
bhlhe22dr11_v1_chr24_+_24461341_244613410.979.2e-06Click!
bhlhe23dr11_v1_chr23_-_17657348_176573480.863.1e-03Click!
si:ch211-196c10.13dr11_v1_chr8_+_23142946_231429460.511.6e-01Click!
bhlha15dr11_v1_chr12_+_17754859_17754859-0.196.2e-01Click!

Activity profile of bhlha15_bhlhe23+si:ch211-196c10.13_bhlhe22 motif

Sorted Z-values of bhlha15_bhlhe23+si:ch211-196c10.13_bhlhe22 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_36693859 5.68 ENSDART00000019259
dlb
deltaB
chr3_+_40809011 4.97 ENSDART00000033713
arpc1b
actin related protein 2/3 complex, subunit 1B
chr17_+_33453689 4.91 ENSDART00000156894
rin3
Ras and Rab interactor 3
chr19_-_21766461 4.59 ENSDART00000104279
znf516
zinc finger protein 516
chr3_+_28953274 4.53 ENSDART00000133528
ENSDART00000103602
lgals2a
lectin, galactoside-binding, soluble, 2a
chr20_+_34326874 4.37 ENSDART00000061659
ivns1abpa
influenza virus NS1A binding protein a
chr17_-_42218652 3.98 ENSDART00000081396
ENSDART00000190007
nkx2.2a
NK2 homeobox 2a
chr19_-_15855427 3.79 ENSDART00000133059
cited4a
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4a
chr10_+_22012389 3.66 ENSDART00000035188
kcnip1b
Kv channel interacting protein 1 b
chr23_-_21453614 3.65 ENSDART00000079274
her4.1
hairy-related 4, tandem duplicate 1
chr23_+_23658474 3.54 ENSDART00000162838
agrn
agrin
chr23_+_21544227 3.07 ENSDART00000140253
arhgef10lb
Rho guanine nucleotide exchange factor (GEF) 10-like b
chr7_-_15413019 3.03 ENSDART00000172147
si:ch211-106j24.1
si:ch211-106j24.1
chr15_+_36457888 2.97 ENSDART00000155100
si:dkey-262k9.2
si:dkey-262k9.2
chr13_+_31285660 2.67 ENSDART00000148352
gdf10a
growth differentiation factor 10a
chr3_+_47322494 2.57 ENSDART00000102202
ppap2d
phosphatidic acid phosphatase type 2D
chr2_-_27775236 2.56 ENSDART00000187983
XKR4
zgc:123035
chr13_-_24311628 2.46 ENSDART00000004420
rab4a
RAB4a, member RAS oncogene family
chr21_+_11468642 2.45 ENSDART00000041869
grin1a
glutamate receptor, ionotropic, N-methyl D-aspartate 1a
chr6_+_54142311 2.44 ENSDART00000154115
hmga1b
high mobility group AT-hook 1b
chr3_-_61205711 2.21 ENSDART00000055062
pvalb1
parvalbumin 1
chr4_+_15968483 2.14 ENSDART00000101575
si:dkey-117n7.5
si:dkey-117n7.5
chr7_-_15413188 2.08 ENSDART00000185980
si:ch211-106j24.1
si:ch211-106j24.1
chr20_-_22476255 2.07 ENSDART00000103510
pdgfra
platelet-derived growth factor receptor, alpha polypeptide
chr17_-_20558961 2.06 ENSDART00000155993
sh3pxd2ab
SH3 and PX domains 2Ab
chr16_-_45225520 2.05 ENSDART00000158855
fxyd1
FXYD domain containing ion transport regulator 1 (phospholemman)
chr3_+_31621774 1.98 ENSDART00000076636
fzd2
frizzled class receptor 2
chr13_-_34781984 1.95 ENSDART00000172138
ism1
isthmin 1
chr1_-_43712120 1.74 ENSDART00000074600
SLC9B2
si:dkey-162b23.4
chr4_-_16354292 1.60 ENSDART00000139919
lum
lumican
chr12_+_24562667 1.54 ENSDART00000056256
nrxn1a
neurexin 1a
chr10_-_31440500 1.48 ENSDART00000024778
robo3
roundabout, axon guidance receptor, homolog 3 (Drosophila)
chr2_-_27774783 1.46 ENSDART00000161864
XKR4
zgc:123035
chr19_+_1184878 1.38 ENSDART00000163539
scrt1a
scratch family zinc finger 1a
chr18_-_14836862 1.26 ENSDART00000124843
mtss1la
metastasis suppressor 1-like a
chr13_-_31441042 1.24 ENSDART00000076571
rtn1a
reticulon 1a
chr4_+_12617108 1.22 ENSDART00000134362
ENSDART00000112860
lmo3
LIM domain only 3
chr3_-_30685401 1.21 ENSDART00000151097
si:ch211-51c14.1
si:ch211-51c14.1
chr1_-_16507812 1.20 ENSDART00000169081
mtmr7b
myotubularin related protein 7b
chr12_-_14922955 1.19 ENSDART00000002078
neurod2
neurogenic differentiation 2
chr2_-_55861351 1.16 ENSDART00000059003
rx2
retinal homeobox gene 2
chr4_-_8882572 1.13 ENSDART00000190060
mpped1
metallophosphoesterase domain containing 1
chr14_-_12071679 1.07 ENSDART00000165581
tmsb1
thymosin beta 1
chr11_+_2202987 1.00 ENSDART00000190008
ENSDART00000173139
hoxc6b
homeobox C6b
chr22_+_11857356 0.99 ENSDART00000179540
mras
muscle RAS oncogene homolog
chr14_-_12071447 0.97 ENSDART00000166116
tmsb1
thymosin beta 1
chr9_-_42989297 0.87 ENSDART00000126871
ttn.2
titin, tandem duplicate 2
chr13_+_28821841 0.83 ENSDART00000179900
CU639469.1

chr17_-_10838434 0.77 ENSDART00000064597
lgals3b
lectin, galactoside binding soluble 3b
chr4_+_14360372 0.76 ENSDART00000007103
nuak1a
NUAK family, SNF1-like kinase, 1a
chr19_+_19786117 0.75 ENSDART00000167757
ENSDART00000163546
hoxa1a
homeobox A1a
chr24_+_2801765 0.75 ENSDART00000172385
LYRM4
si:ch211-152c8.4
chr6_-_10964083 0.74 ENSDART00000181583
notum2
notum pectinacetylesterase 2
chr3_-_26109322 0.73 ENSDART00000113780
zgc:162612
zgc:162612
chr20_+_6773790 0.73 ENSDART00000169966
igfbp3
insulin-like growth factor binding protein 3
chr15_-_14884332 0.71 ENSDART00000165237
si:ch211-24o8.4
si:ch211-24o8.4
chr23_-_4019699 0.69 ENSDART00000159780
slc9a8
solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
chr13_+_31286076 0.69 ENSDART00000142725
gdf10a
growth differentiation factor 10a
chr7_-_50395059 0.69 ENSDART00000191150
vps33b
vacuolar protein sorting 33B
chr14_-_4556896 0.65 ENSDART00000044678
ENSDART00000192863
GABRA2
gamma-aminobutyric acid type A receptor alpha2 subunit
chr11_+_3989403 0.62 ENSDART00000082379
spcs1
signal peptidase complex subunit 1
chr6_-_10963887 0.62 ENSDART00000151102
notum2
notum pectinacetylesterase 2
chr18_+_48428126 0.62 ENSDART00000137978
fli1a
Fli-1 proto-oncogene, ETS transcription factor a
chr4_+_5796761 0.61 ENSDART00000164854
si:ch73-352p4.8
si:ch73-352p4.8
chr14_-_15956657 0.61 ENSDART00000169197
flt4
fms-related tyrosine kinase 4
chr8_-_3773374 0.61 ENSDART00000115036
bicdl1
BICD family like cargo adaptor 1
chr24_+_13925066 0.58 ENSDART00000134221
ENSDART00000012253
ENSDART00000081595
ENSDART00000136443
eya1
EYA transcriptional coactivator and phosphatase 1
chr18_+_50687702 0.57 ENSDART00000159877
p2ry1
purinergic receptor P2Y1
chr5_-_24127310 0.57 ENSDART00000182700
ENSDART00000154313
capga
capping protein (actin filament), gelsolin-like a
chr15_-_14486534 0.57 ENSDART00000179368
numbl
numb homolog (Drosophila)-like
chr3_+_50310684 0.56 ENSDART00000112152
gas7a
growth arrest-specific 7a
chr15_+_15856178 0.54 ENSDART00000080338
dusp14
dual specificity phosphatase 14
chr13_+_674351 0.51 ENSDART00000111328
cutc
cutC copper transporter homolog (E. coli)
chr7_-_50395395 0.50 ENSDART00000065868
vps33b
vacuolar protein sorting 33B
chr12_-_3753131 0.50 ENSDART00000129668
fam57bb
family with sequence similarity 57, member Bb
chr20_+_39283849 0.50 ENSDART00000002481
ENSDART00000146683
scara3
scavenger receptor class A, member 3
chr22_-_23067859 0.49 ENSDART00000137873
ptprc
protein tyrosine phosphatase, receptor type, C
chr22_-_18116635 0.48 ENSDART00000005724
ncanb
neurocan b
chr24_+_14527935 0.48 ENSDART00000134846
si:dkeyp-73g8.5
si:dkeyp-73g8.5
chr9_+_29994439 0.47 ENSDART00000012447
tmem30c
transmembrane protein 30C
chr2_+_33383227 0.45 ENSDART00000183068
slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr12_-_35095414 0.43 ENSDART00000153229
si:dkey-21e13.3
si:dkey-21e13.3
chr19_+_32822269 0.42 ENSDART00000052097
ENSDART00000052096
ENSDART00000188012
rida
reactive intermediate imine deaminase A homolog
chr22_-_24248420 0.42 ENSDART00000165433
rgs2
regulator of G protein signaling 2
chr14_+_25817246 0.41 ENSDART00000136733
glra1
glycine receptor, alpha 1
chr21_-_40174647 0.40 ENSDART00000183738
ENSDART00000076840
ENSDART00000145109
slco2b1
solute carrier organic anion transporter family, member 2B1
chr20_+_43379029 0.40 ENSDART00000142486
ENSDART00000186486
unc93a
unc-93 homolog A
chr19_-_10771558 0.39 ENSDART00000085165
slc9a3.2
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3, tandem duplicate 2
chr1_-_16394814 0.38 ENSDART00000013024
fgf20a
fibroblast growth factor 20a
chr14_-_15956921 0.38 ENSDART00000190500
flt4
fms-related tyrosine kinase 4
chr19_+_31904836 0.38 ENSDART00000162297
ENSDART00000088340
ENSDART00000151280
ENSDART00000151218
tpd52
tumor protein D52
chr20_-_8365244 0.36 ENSDART00000167102
dab1a
Dab, reelin signal transducer, homolog 1a (Drosophila)
chr14_-_46117345 0.34 ENSDART00000172166
NDUFC1
si:ch211-235e9.6
chr7_+_11390462 0.32 ENSDART00000114383
tlnrd1
talin rod domain containing 1
chr14_+_36521553 0.30 ENSDART00000136233
TENM3
si:dkey-237h12.3
chr2_-_32551178 0.29 ENSDART00000145603
smarcd3a
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3a
chr4_+_20318127 0.29 ENSDART00000028856
ENSDART00000132909
cacna1c
calcium channel, voltage-dependent, L type, alpha 1C subunit
chr1_+_5275811 0.27 ENSDART00000189676
spry2
sprouty RTK signaling antagonist 2
chr14_+_25816874 0.26 ENSDART00000005499
glra1
glycine receptor, alpha 1
chr22_-_188102 0.25 ENSDART00000125391
ENSDART00000170463
CABZ01052268.1

chr19_-_7540821 0.25 ENSDART00000143958
lix1l
limb and CNS expressed 1 like
chr24_-_21913426 0.22 ENSDART00000081178
c1qtnf9
C1q and TNF related 9
chr1_-_10847753 0.22 ENSDART00000141052
dmd
dystrophin
chr11_+_6684968 0.21 ENSDART00000139454
pde4cb
phosphodiesterase 4C, cAMP-specific b
chr2_+_7075220 0.20 ENSDART00000022963
cdc14aa
cell division cycle 14Aa
chr16_+_13424534 0.20 ENSDART00000114944
zgc:101640
zgc:101640
chr20_+_18994059 0.20 ENSDART00000152380
tdh
L-threonine dehydrogenase
chr13_-_17723417 0.19 ENSDART00000183834
vdac2
voltage-dependent anion channel 2
chr20_-_456998 0.19 ENSDART00000149973
frk
fyn-related Src family tyrosine kinase
chr3_-_52674089 0.19 ENSDART00000154260
ENSDART00000125455
si:dkey-210j14.4
si:dkey-210j14.4
chr19_-_22568203 0.17 ENSDART00000182888
pleca
plectin a
chr6_+_14980761 0.16 ENSDART00000087782
mrps9
mitochondrial ribosomal protein S9
chr11_-_16152400 0.13 ENSDART00000123665
arpc4l
actin related protein 2/3 complex, subunit 4, like
chr6_-_36182115 0.12 ENSDART00000154639
brinp3a.2
bone morphogenetic protein/retinoic acid inducible neural-specific 3a, tandem duplicate 2
chr17_+_12658411 0.11 ENSDART00000139918
gpn1
GPN-loop GTPase 1
chr5_-_25066780 0.11 ENSDART00000002118
ENSDART00000182575
pnpla7b
patatin-like phospholipase domain containing 7b
chr19_-_17864213 0.10 ENSDART00000151043
ints8
integrator complex subunit 8
chr2_-_5074812 0.09 ENSDART00000163728
dlg1l
discs, large (Drosophila) homolog 1, like
chr23_+_26491931 0.08 ENSDART00000190124
ENSDART00000132905
si:ch73-206d17.1
si:ch73-206d17.1
chr10_+_22536693 0.08 ENSDART00000185037
ENSDART00000146040
efnb3a
ephrin-B3a
chr17_+_28882977 0.07 ENSDART00000153937
prkd1
protein kinase D1
chr1_+_47486104 0.07 ENSDART00000114746
lrrc58a
leucine rich repeat containing 58a
chr14_-_30897177 0.06 ENSDART00000087918
slc7a3b
solute carrier family 7 (cationic amino acid transporter, y+ system), member 3b
chr1_+_42874410 0.06 ENSDART00000153506
ctnna2
catenin (cadherin-associated protein), alpha 2
chr7_-_18508815 0.06 ENSDART00000173539
rgs12a
regulator of G protein signaling 12a
chr3_-_24909245 0.06 ENSDART00000178321
SHISA8
shisa family member 8
chr10_-_23358357 0.04 ENSDART00000135475
cadm2a
cell adhesion molecule 2a
chr13_-_41908583 0.04 ENSDART00000136515
ipmka
inositol polyphosphate multikinase a
chr11_-_16152105 0.04 ENSDART00000081062
arpc4l
actin related protein 2/3 complex, subunit 4, like
chr20_-_33462961 0.03 ENSDART00000135927
si:dkey-65b13.1
si:dkey-65b13.1
chr1_-_17711636 0.03 ENSDART00000148322
ENSDART00000122670
ufsp2
ufm1-specific peptidase 2
chr21_-_25601648 0.02 ENSDART00000042578
efemp2b
EGF containing fibulin extracellular matrix protein 2b
chr6_+_46668717 0.02 ENSDART00000064853
oxtrl
oxytocin receptor like
chr10_+_24445698 0.01 ENSDART00000146370
slc7a1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr13_+_30421472 0.01 ENSDART00000143569
zmiz1a
zinc finger, MIZ-type containing 1a
chr20_+_18702624 0.01 ENSDART00000185605
ENSDART00000019476
ENSDART00000152533
eif5
eukaryotic translation initiation factor 5
chr19_-_7406933 0.01 ENSDART00000151137
oxr1b
oxidation resistance 1b
chr12_+_15487834 0.01 ENSDART00000181138
arhgap23b
Rho GTPase activating protein 23b
chr3_-_57779801 0.01 ENSDART00000074285
syngr2a
synaptogyrin 2a
chr8_+_27555314 0.01 ENSDART00000135568
ENSDART00000016696
rhocb
ras homolog family member Cb
chr15_+_14145346 0.00 ENSDART00000047531
clca5.2
chloride channel accessory 5, tandem duplicate 2
chr15_-_4314042 0.00 ENSDART00000173311
ENSDART00000170562
ECE2
si:ch211-117a13.2

Network of associatons between targets according to the STRING database.

First level regulatory network of bhlha15_bhlhe23+si:ch211-196c10.13_bhlhe22

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 4.0 GO:0021530 spinal cord oligodendrocyte cell fate specification(GO:0021530)
1.2 3.5 GO:1902571 regulation of serine-type peptidase activity(GO:1902571)
0.7 2.0 GO:0061341 non-canonical Wnt signaling pathway involved in heart development(GO:0061341)
0.4 2.1 GO:0003261 cardiac muscle progenitor cell migration to the midline involved in heart field formation(GO:0003261)
0.3 1.4 GO:1990697 protein depalmitoleylation(GO:1990697)
0.3 4.5 GO:0090303 positive regulation of wound healing(GO:0090303)
0.3 1.2 GO:0060074 synapse maturation(GO:0060074)
0.2 5.0 GO:0002574 thrombocyte differentiation(GO:0002574)
0.2 3.1 GO:0071501 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.2 0.7 GO:0071361 cellular response to ethanol(GO:0071361)
0.2 2.0 GO:0042989 sequestering of actin monomers(GO:0042989)
0.2 1.0 GO:0060836 lymphatic endothelial cell differentiation(GO:0060836)
0.2 5.1 GO:0043171 peptide catabolic process(GO:0043171)
0.2 6.2 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.2 3.6 GO:0048936 peripheral nervous system neuron axonogenesis(GO:0048936)
0.2 0.8 GO:0072677 eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.2 0.6 GO:0055107 Golgi to secretory granule transport(GO:0055107)
0.1 2.4 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.1 1.9 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.1 0.5 GO:0060092 regulation of synaptic transmission, glycinergic(GO:0060092)
0.1 1.5 GO:0016199 axon midline choice point recognition(GO:0016199)
0.1 0.4 GO:0090299 regulation of neural crest formation(GO:0090299)
0.1 0.6 GO:0090075 relaxation of muscle(GO:0090075)
0.1 2.5 GO:0032482 Rab protein signal transduction(GO:0032482)
0.1 2.1 GO:0006801 superoxide metabolic process(GO:0006801)
0.1 3.4 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.1 0.7 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.1 0.6 GO:1901099 histone dephosphorylation(GO:0016576) negative regulation of signal transduction in absence of ligand(GO:1901099) regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001239) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.1 1.3 GO:0097178 ruffle assembly(GO:0097178)
0.1 0.3 GO:0014896 muscle hypertrophy(GO:0014896)
0.1 1.2 GO:0097320 membrane tubulation(GO:0097320)
0.1 0.9 GO:0048769 sarcomerogenesis(GO:0048769)
0.1 0.5 GO:0055070 copper ion homeostasis(GO:0055070)
0.0 0.4 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.0 0.4 GO:0097477 spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477)
0.0 3.8 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.0 1.2 GO:0035622 intrahepatic bile duct development(GO:0035622)
0.0 1.6 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.4 GO:0046850 regulation of bone remodeling(GO:0046850)
0.0 0.3 GO:0006337 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0 1.2 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.0 0.4 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 0.3 GO:0070373 negative regulation of ERK1 and ERK2 cascade(GO:0070373)
0.0 0.8 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.2 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.0 0.2 GO:0007525 somatic muscle development(GO:0007525)
0.0 0.6 GO:0051014 actin filament severing(GO:0051014)
0.0 0.4 GO:0030183 B cell differentiation(GO:0030183)
0.0 0.1 GO:0051823 regulation of synapse structural plasticity(GO:0051823)
0.0 0.7 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.1 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.1 GO:1901490 protein kinase D signaling(GO:0089700) regulation of lymphangiogenesis(GO:1901490)
0.0 0.2 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 0.2 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.1 GO:0006567 threonine metabolic process(GO:0006566) threonine catabolic process(GO:0006567)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.0 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.2 2.5 GO:0032593 insulin-responsive compartment(GO:0032593)
0.2 1.2 GO:0033263 CORVET complex(GO:0033263)
0.2 2.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 0.8 GO:0001772 immunological synapse(GO:0001772)
0.0 0.4 GO:0031526 brush border membrane(GO:0031526)
0.0 0.2 GO:1902636 kinociliary basal body(GO:1902636)
0.0 0.3 GO:0071564 npBAF complex(GO:0071564)
0.0 0.7 GO:0043204 perikaryon(GO:0043204)
0.0 0.2 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.9 GO:0005814 centriole(GO:0005814)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 5.3 GO:0016936 galactoside binding(GO:0016936)
0.5 2.1 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017) platelet-derived growth factor binding(GO:0048407)
0.3 1.4 GO:1990699 palmitoleyl hydrolase activity(GO:1990699)
0.2 2.1 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.2 5.7 GO:0005112 Notch binding(GO:0005112)
0.2 3.5 GO:0043236 laminin binding(GO:0043236)
0.2 5.1 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 2.0 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 2.4 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.1 2.0 GO:0003785 actin monomer binding(GO:0003785)
0.1 2.6 GO:0042577 lipid phosphatase activity(GO:0042577)
0.1 1.0 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.1 0.6 GO:0034452 dynactin binding(GO:0034452)
0.1 0.7 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.1 0.7 GO:0031995 insulin-like growth factor I binding(GO:0031994) insulin-like growth factor II binding(GO:0031995)
0.1 1.2 GO:0004438 phosphatidylinositol-3-phosphatase activity(GO:0004438)
0.0 1.5 GO:0098632 protein binding involved in cell adhesion(GO:0098631) protein binding involved in cell-cell adhesion(GO:0098632)
0.0 0.2 GO:0015288 porin activity(GO:0015288)
0.0 0.6 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 1.0 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.4 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 0.5 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 0.5 GO:0033549 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.0 1.0 GO:0019003 GDP binding(GO:0019003)
0.0 3.1 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 2.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.1 GO:0008743 L-threonine 3-dehydrogenase activity(GO:0008743)
0.0 3.4 GO:0005125 cytokine activity(GO:0005125)
0.0 0.4 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 5.0 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.0 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.0 0.6 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.7 GO:0015179 L-amino acid transmembrane transporter activity(GO:0015179)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.1 5.0 PID RAC1 PATHWAY RAC1 signaling pathway
0.1 2.0 PID WNT SIGNALING PATHWAY Wnt signaling network
0.1 3.5 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.1 1.6 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 2.1 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 0.9 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.0 0.7 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.5 SIG BCR SIGNALING PATHWAY Members of the BCR signaling pathway
0.0 0.3 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.0 0.1 PID IGF1 PATHWAY IGF1 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.5 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 1.6 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 1.0 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 0.7 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 0.5 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.4 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 0.6 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.9 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 2.0 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.5 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.9 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.3 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling