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PRJNA195909:zebrafish embryo and larva development

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Results for dmbx1a+dmbx1b

Z-value: 0.61

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Transcription factors associated with dmbx1a+dmbx1b

Gene Symbol Gene ID Gene Info
dmbx1b
ENSDARG00000002510 diencephalon/mesencephalon homeobox 1b
dmbx1a
ENSDARG00000009922 diencephalon/mesencephalon homeobox 1a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
dmbx1bdr11_v1_chr6_-_3573716_3573716-0.363.5e-01Click!
dmbx1adr11_v1_chr2_-_10192459_10192487-0.176.6e-01Click!

Activity profile of dmbx1a+dmbx1b motif

Sorted Z-values of dmbx1a+dmbx1b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_56577906 0.93 ENSDART00000184023
hp
haptoglobin
chr4_-_16628801 0.46 ENSDART00000040708
ENSDART00000064009
caprin2
caprin family member 2
chr18_+_20567542 0.45 ENSDART00000182585
bida
BH3 interacting domain death agonist
chr1_-_12126535 0.40 ENSDART00000164817
ENSDART00000015251
mttp
microsomal triglyceride transfer protein
chr23_-_3759692 0.38 ENSDART00000028885
hmga1a
high mobility group AT-hook 1a
chr12_+_33894396 0.38 ENSDART00000130853
ENSDART00000152988
mfsd13a
major facilitator superfamily domain containing 13A
chr23_-_3759345 0.37 ENSDART00000132205
ENSDART00000137707
ENSDART00000189382
hmga1a
high mobility group AT-hook 1a
chr13_-_31938512 0.35 ENSDART00000026726
ENSDART00000182666
diexf
digestive organ expansion factor homolog
chr3_+_23092762 0.32 ENSDART00000142884
ENSDART00000024136
gngt2a
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2a
chr20_-_42534504 0.28 ENSDART00000132310
rfx6
regulatory factor X, 6
chr23_-_545942 0.27 ENSDART00000105316
samhd1
SAM domain and HD domain 1
chr19_-_30811161 0.27 ENSDART00000103524
myclb
MYCL proto-oncogene, bHLH transcription factor b
chr18_-_10713414 0.26 ENSDART00000034817
rbm28
RNA binding motif protein 28
chr15_-_6976851 0.25 ENSDART00000158474
ENSDART00000168943
ENSDART00000169944
si:ch73-311h14.2
si:ch73-311h14.2
chr5_-_22602979 0.25 ENSDART00000146287
nono
non-POU domain containing, octamer-binding
chr3_-_41995321 0.25 ENSDART00000192277
ttyh3a
tweety family member 3a
chr12_+_33894665 0.25 ENSDART00000004769
mfsd13a
major facilitator superfamily domain containing 13A
chr14_-_46238186 0.25 ENSDART00000173245
si:ch211-113d11.6
si:ch211-113d11.6
chr18_-_10713230 0.24 ENSDART00000183646
rbm28
RNA binding motif protein 28
chr19_+_2631565 0.23 ENSDART00000171487
fam126a
family with sequence similarity 126, member A
chr16_-_46578523 0.23 ENSDART00000131061
si:dkey-152b24.6
si:dkey-152b24.6
chr5_-_22602780 0.23 ENSDART00000011699
nono
non-POU domain containing, octamer-binding
chr12_+_17042754 0.22 ENSDART00000066439
ch25h
cholesterol 25-hydroxylase
chr2_-_9744081 0.22 ENSDART00000097732
dvl3a
dishevelled segment polarity protein 3a
chr25_-_35121946 0.22 ENSDART00000137502
si:ch73-36p18.1
si:ch73-36p18.1
chr19_+_24324967 0.21 ENSDART00000090081
sema4ab
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Ab
chr4_+_8680767 0.21 ENSDART00000182726
adipor2
adiponectin receptor 2
chr16_+_16265850 0.21 ENSDART00000181265
setd2
SET domain containing 2
chr15_-_7337148 0.21 ENSDART00000182568
SLC7A1 (1 of many)
high affinity cationic amino acid transporter 1
chr4_-_59152337 0.20 ENSDART00000156770
znf1149
zinc finger protein 1149
chr1_-_9130136 0.20 ENSDART00000113013
palb2
partner and localizer of BRCA2
chr5_-_69180227 0.20 ENSDART00000154816
zgc:171967
zgc:171967
chr2_+_44972720 0.20 ENSDART00000075146
alg3
asparagine-linked glycosylation 3 (alpha-1,3-mannosyltransferase)
chr11_+_29671661 0.20 ENSDART00000024318
ENSDART00000165024
rnf207a
ring finger protein 207a
chr5_-_25733745 0.19 ENSDART00000051566
zgc:101016
zgc:101016
chr4_-_76488581 0.19 ENSDART00000174291
ftr51
finTRIM family, member 51
chr7_-_21905851 0.19 ENSDART00000111066
ENSDART00000020288
epoa
erythropoietin a
chr8_+_46327350 0.18 ENSDART00000145618
si:dkey-75a21.2
si:dkey-75a21.2
chr10_-_7988396 0.18 ENSDART00000141445
ENSDART00000024282
ewsr1a
EWS RNA-binding protein 1a
chr9_+_48123224 0.17 ENSDART00000141610
klhl23
kelch-like family member 23
chr19_+_3140313 0.17 ENSDART00000125504
zgc:86598
zgc:86598
chr10_+_6013076 0.16 ENSDART00000167613
ENSDART00000159216
hmgcs1
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chr17_+_10593398 0.16 ENSDART00000168897
ENSDART00000193989
ENSDART00000191664
ENSDART00000167188
mapkbp1
mitogen-activated protein kinase binding protein 1
chr23_-_1065435 0.15 ENSDART00000138150
si:ch1073-272j17.3
si:ch1073-272j17.3
chr4_+_55593843 0.15 ENSDART00000163356
znf1078
zinc finger protein 1078
chr5_-_5243079 0.14 ENSDART00000130576
ENSDART00000164377
mvb12ba
multivesicular body subunit 12Ba
chr13_+_1015749 0.14 ENSDART00000190982
prokr1b
prokineticin receptor 1b
chr2_+_243778 0.13 ENSDART00000182262
CABZ01085887.1

chr23_-_27050083 0.13 ENSDART00000142324
ENSDART00000133249
ENSDART00000138751
ENSDART00000128718
zgc:66440
zgc:66440
chr5_-_69180587 0.12 ENSDART00000156681
ENSDART00000160753
zgc:171967
zgc:171967
chr4_-_4256300 0.12 ENSDART00000103319
ENSDART00000150279
cd9b
CD9 molecule b
chr4_-_42039794 0.12 ENSDART00000110313
si:dkeyp-85d8.5
si:dkeyp-85d8.5
chr18_+_50525109 0.12 ENSDART00000098390
ubl7b
ubiquitin-like 7b (bone marrow stromal cell-derived)
chr4_+_47385355 0.12 ENSDART00000163413
znf1122
zinc finger protein 1122
chr7_+_65121743 0.12 ENSDART00000108471
ipo7
importin 7
chr23_-_29553430 0.12 ENSDART00000157773
ENSDART00000126384
ube4b
ubiquitination factor E4B, UFD2 homolog (S. cerevisiae)
chr13_-_14269626 0.12 ENSDART00000079176
gfra4a
GDNF family receptor alpha 4a
chr2_-_38363017 0.12 ENSDART00000088026
prmt5
protein arginine methyltransferase 5
chr12_+_33460794 0.12 ENSDART00000007053
ENSDART00000142716
narf
nuclear prelamin A recognition factor
chr4_-_50722304 0.11 ENSDART00000150480
znf1110
zinc finger protein 1110
chr16_-_21692024 0.11 ENSDART00000123597
si:ch211-154o6.2
si:ch211-154o6.2
chr17_-_21617618 0.11 ENSDART00000109031
gpr26
G protein-coupled receptor 26
chr23_+_16815353 0.11 ENSDART00000142789
ENSDART00000143424
zgc:100832
zgc:100832
chr25_+_36411624 0.10 ENSDART00000124347
ankrd27
ankyrin repeat domain 27 (VPS9 domain)
chr20_-_21672970 0.10 ENSDART00000133286
si:ch211-207i1.2
si:ch211-207i1.2
chr8_+_54263946 0.10 ENSDART00000193119
TMCC1 (1 of many)
transmembrane and coiled-coil domain family 1
chr16_+_37876779 0.10 ENSDART00000140148
si:ch211-198c19.1
si:ch211-198c19.1
chr17_-_8656155 0.09 ENSDART00000148990
ctbp2a
C-terminal binding protein 2a
chr10_+_21899753 0.09 ENSDART00000080155
hrh2b
histamine receptor H2b
chr23_-_29553691 0.09 ENSDART00000053804
ube4b
ubiquitination factor E4B, UFD2 homolog (S. cerevisiae)
chr4_+_33012407 0.09 ENSDART00000151873
si:dkey-26h11.2
si:dkey-26h11.2
chr4_+_31450683 0.08 ENSDART00000169303
znf996
zinc finger protein 996
chr15_-_41734639 0.08 ENSDART00000154230
ENSDART00000167443
ftr90
finTRIM family, member 90
chr4_-_56083825 0.08 ENSDART00000157710
znf986
zinc finger protein 986
chr6_-_39653972 0.08 ENSDART00000155859
larp4ab
La ribonucleoprotein domain family, member 4Ab
chr4_+_36906436 0.08 ENSDART00000136773
BX537137.1

chr13_-_35892243 0.08 ENSDART00000002750
ENSDART00000122810
ENSDART00000162399
tacc3
transforming, acidic coiled-coil containing protein 3
chr13_-_36581875 0.08 ENSDART00000113204
lgals3a
lectin, galactoside binding soluble 3a
chr5_-_8817841 0.07 ENSDART00000170921
fgf10b
fibroblast growth factor 10b
chr1_+_35949269 0.07 ENSDART00000180628
BX276105.3

chr18_+_21951551 0.07 ENSDART00000146261
ranbp10
RAN binding protein 10
chr20_-_33515890 0.07 ENSDART00000159987
si:dkey-65b13.13
si:dkey-65b13.13
chr23_+_16814968 0.07 ENSDART00000161299
zgc:100832
zgc:100832
chr9_+_21990095 0.06 ENSDART00000146829
ENSDART00000133515
ENSDART00000193582
si:dkey-57a22.13
si:dkey-57a22.13
chr7_-_54320088 0.06 ENSDART00000172396
fadd
Fas (tnfrsf6)-associated via death domain
chr18_+_33172634 0.06 ENSDART00000151519
si:ch73-125k17.2
si:ch73-125k17.2
chr8_+_14381272 0.06 ENSDART00000057642
acbd6
acyl-CoA binding domain containing 6
chr4_-_18455480 0.06 ENSDART00000150221
sco2
SCO2 cytochrome c oxidase assembly protein
chr11_+_27973055 0.05 ENSDART00000135135
alpl
alkaline phosphatase, liver/bone/kidney
chr20_+_12830448 0.05 ENSDART00000164754
BX547930.4

chr10_-_18468385 0.05 ENSDART00000183302
si:dkey-28o19.1
si:dkey-28o19.1
chr13_-_35892051 0.04 ENSDART00000145884
tacc3
transforming, acidic coiled-coil containing protein 3
chr7_+_19904136 0.04 ENSDART00000173452
si:ch211-285j22.3
si:ch211-285j22.3
chr25_-_32381642 0.04 ENSDART00000133872
ENSDART00000006124
cops2
COP9 signalosome subunit 2
chr18_-_21950751 0.04 ENSDART00000043452
tsnaxip1
translin-associated factor X interacting protein 1
chr22_+_2709467 0.04 ENSDART00000141416
znf1171
zinc finger protein 1171
chr4_+_73876128 0.04 ENSDART00000174225
CABZ01069022.1

chr7_-_35409027 0.04 ENSDART00000128334
lpcat2
lysophosphatidylcholine acyltransferase 2
chr3_-_21402279 0.03 ENSDART00000164513
CT573446.1

chr23_-_26652273 0.03 ENSDART00000112124
ENSDART00000111029
hspg2
heparan sulfate proteoglycan 2
chr4_-_49133107 0.03 ENSDART00000150806
znf1146
zinc finger protein 1146
chr14_-_3944017 0.03 ENSDART00000055817
si:ch73-49o8.1
si:ch73-49o8.1
chr25_+_11456696 0.03 ENSDART00000171408
AGBL1
si:ch73-141f14.1
chr21_+_44773237 0.02 ENSDART00000084780
rnf121
ring finger protein 121
chr14_+_2487672 0.02 ENSDART00000170629
ENSDART00000123063
fgf18a
fibroblast growth factor 18a
chr5_+_25733774 0.02 ENSDART00000137088
ENSDART00000098467
abhd17b
abhydrolase domain containing 17B
chr5_-_8817458 0.02 ENSDART00000191098
fgf10b
fibroblast growth factor 10b
chr12_+_292452 0.02 ENSDART00000189944
CABZ01058222.1

chr22_+_13886821 0.02 ENSDART00000130585
ENSDART00000105711
sh3bp4a
SH3-domain binding protein 4a
chr7_+_19903924 0.02 ENSDART00000159112
si:ch211-285j22.3
si:ch211-285j22.3
chr20_-_31308805 0.02 ENSDART00000147045
hpcal1
hippocalcin-like 1
chr23_+_45512825 0.02 ENSDART00000064846
prelid1b
PRELI domain containing 1b
chr3_-_15139293 0.02 ENSDART00000161213
ENSDART00000146053
fam173a
family with sequence similarity 173, member A
chr12_-_13081229 0.02 ENSDART00000152510
ENSDART00000126866
ccser2b
coiled-coil serine-rich protein 2b
chr18_+_5172848 0.02 ENSDART00000190642
CABZ01080599.1

chr4_+_40383229 0.01 ENSDART00000126906
ENSDART00000191198
si:ch211-218h8.1
si:ch211-218h8.1
chr4_-_76488854 0.01 ENSDART00000132323
ftr51
finTRIM family, member 51
chr25_+_19041329 0.01 ENSDART00000153467
lrtm2b
leucine-rich repeats and transmembrane domains 2b
chr21_+_21709204 0.01 ENSDART00000137478
or125-1
odorant receptor, family E, subfamily 125, member 1
chr3_+_34919810 0.01 ENSDART00000055264
ca10b
carbonic anhydrase Xb
chr1_+_52560549 0.01 ENSDART00000167514
abca1a
ATP-binding cassette, sub-family A (ABC1), member 1A
chr22_+_6740039 0.00 ENSDART00000144122
CT583625.2

chr18_+_15182965 0.00 ENSDART00000137018
si:ch73-62b13.1
si:ch73-62b13.1
chr18_-_5103931 0.00 ENSDART00000188091
pdcd10a
programmed cell death 10a

Network of associatons between targets according to the STRING database.

First level regulatory network of dmbx1a+dmbx1b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:2000055 positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000055)
0.1 0.5 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway(GO:2001244)
0.1 0.3 GO:0035773 insulin secretion involved in cellular response to glucose stimulus(GO:0035773) regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.1 0.3 GO:0016446 somatic diversification of immune receptors via somatic mutation(GO:0002566) somatic hypermutation of immunoglobulin genes(GO:0016446)
0.1 0.2 GO:1902767 farnesyl diphosphate biosynthetic process, mevalonate pathway(GO:0010142) isoprenoid biosynthetic process via mevalonate(GO:1902767)
0.1 0.4 GO:0001579 medium-chain fatty acid transport(GO:0001579)
0.0 0.2 GO:0061181 regulation of chondrocyte development(GO:0061181)
0.0 0.2 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.0 0.1 GO:0044803 virion assembly(GO:0019068) virus maturation(GO:0019075) multi-organism membrane organization(GO:0044803) viral budding(GO:0046755) multi-organism organelle organization(GO:1902590) multi-organism membrane budding(GO:1902592)
0.0 0.2 GO:0097198 histone H3-K36 trimethylation(GO:0097198)
0.0 0.2 GO:0090178 establishment of planar polarity of embryonic epithelium(GO:0042249) establishment of planar polarity involved in neural tube closure(GO:0090177) regulation of establishment of planar polarity involved in neural tube closure(GO:0090178) planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.0 0.1 GO:0034969 histone arginine methylation(GO:0034969)
0.0 0.2 GO:0048823 nucleate erythrocyte development(GO:0048823)
0.0 0.1 GO:0061033 lung growth(GO:0060437) secretion by lung epithelial cell involved in lung growth(GO:0061033)
0.0 0.1 GO:0036462 TRAIL-activated apoptotic signaling pathway(GO:0036462)
0.0 0.1 GO:0072677 eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.0 0.1 GO:0070073 clustering of voltage-gated calcium channels(GO:0070073)
0.0 0.1 GO:0030431 sleep(GO:0030431)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.0 0.2 GO:0005956 protein kinase CK2 complex(GO:0005956)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:1904121 phosphatidylethanolamine transporter activity(GO:1904121)
0.1 0.2 GO:0005128 erythropoietin receptor binding(GO:0005128)
0.1 0.2 GO:0004421 hydroxymethylglutaryl-CoA synthase activity(GO:0004421)
0.0 0.2 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.0 0.3 GO:0008832 dGTPase activity(GO:0008832) triphosphoric monoester hydrolase activity(GO:0016793)
0.0 0.1 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.0 0.2 GO:0000254 C-4 methylsterol oxidase activity(GO:0000254)
0.0 0.2 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.1 GO:0005521 lamin binding(GO:0005521)
0.0 0.3 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.0 0.3 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.1 GO:0019865 IgE binding(GO:0019863) immunoglobulin binding(GO:0019865)
0.0 0.2 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 0.2 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 0.1 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID CIRCADIAN PATHWAY Circadian rhythm pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.2 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS Genes involved in Synthesis of bile acids and bile salts
0.0 0.2 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway