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PRJNA195909:zebrafish embryo and larva development

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Results for e2f2_e2f5

Z-value: 3.30

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Transcription factors associated with e2f2_e2f5

Gene Symbol Gene ID Gene Info
e2f2
ENSDARG00000079233 si_ch211-160f23.5
e2f5
ENSDARG00000038812 E2F transcription factor 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
e2f5dr11_v1_chr2_-_31686353_316864030.882.0e-03Click!
E2F2dr11_v1_chr17_-_27266053_272660530.373.3e-01Click!

Activity profile of e2f2_e2f5 motif

Sorted Z-values of e2f2_e2f5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_11792766 7.18 ENSDART00000011657
cdc6
cell division cycle 6 homolog (S. cerevisiae)
chr9_-_2892250 5.30 ENSDART00000140695
cdca7a
cell division cycle associated 7a
chr3_-_54607166 5.29 ENSDART00000021977
dnmt1
DNA (cytosine-5-)-methyltransferase 1
chr1_-_8553165 5.03 ENSDART00000135197
ENSDART00000054981
zgc:112980
zgc:112980
chr20_+_35438300 4.82 ENSDART00000102504
ENSDART00000153249
tdrd6
tudor domain containing 6
chr15_-_17099560 4.61 ENSDART00000101724
mos
v-mos Moloney murine sarcoma viral oncogene homolog
chr10_-_21362071 4.40 ENSDART00000125167
avd
avidin
chr2_+_44512324 4.15 ENSDART00000155017
ENSDART00000156310
ENSDART00000156686
pask
PAS domain containing serine/threonine kinase
chr7_+_55518519 3.84 ENSDART00000098476
ENSDART00000149915
cdt1
chromatin licensing and DNA replication factor 1
chr9_+_22780901 3.79 ENSDART00000110992
ENSDART00000143972
rif1
replication timing regulatory factor 1
chr13_-_13030851 3.69 ENSDART00000009499
nsd2
nuclear receptor binding SET domain protein 2
chr22_-_4439311 3.66 ENSDART00000169317
uhrf1
ubiquitin-like with PHD and ring finger domains 1
chr2_-_29923630 3.52 ENSDART00000158844
ENSDART00000031130
paxip1
PAX interacting (with transcription-activation domain) protein 1
chr2_-_29923403 3.51 ENSDART00000144672
paxip1
PAX interacting (with transcription-activation domain) protein 1
chr22_-_38274188 3.44 ENSDART00000139420
ENSDART00000015117
elavl2
ELAV like neuron-specific RNA binding protein 2
chr3_+_26244353 3.39 ENSDART00000103733
atad5a
ATPase family, AAA domain containing 5a
chr6_+_33931740 3.32 ENSDART00000130492
ENSDART00000151213
orc1
origin recognition complex, subunit 1
chr7_+_41812636 3.19 ENSDART00000174333
orc6
origin recognition complex, subunit 6
chr9_-_2892045 3.18 ENSDART00000137201
cdca7a
cell division cycle associated 7a
chr7_+_41812817 2.94 ENSDART00000174165
orc6
origin recognition complex, subunit 6
chr25_+_35375848 2.84 ENSDART00000155721
ano3
anoctamin 3
chr7_-_6464225 2.80 ENSDART00000130760
hist1h2a4
histone cluster 1 H2A family member 4
chr19_-_2822372 2.79 ENSDART00000109130
ENSDART00000122385
recql4
RecQ helicase-like 4
chr5_-_54395488 2.78 ENSDART00000160781
zmynd19
zinc finger, MYND-type containing 19
chr5_-_12743196 2.74 ENSDART00000188976
ENSDART00000137705
lztr1
leucine-zipper-like transcription regulator 1
chr19_-_20403845 2.72 ENSDART00000151265
ENSDART00000147911
ENSDART00000151356
dazl
deleted in azoospermia-like
chr2_+_38055529 2.68 ENSDART00000145642
si:rp71-1g18.1
si:rp71-1g18.1
chr19_-_47571797 2.67 ENSDART00000166180
ENSDART00000168134
rrm2
ribonucleotide reductase M2 polypeptide
chr7_+_41812190 2.66 ENSDART00000113732
ENSDART00000174137
orc6
origin recognition complex, subunit 6
chr5_+_34549845 2.63 ENSDART00000139317
aif1l
allograft inflammatory factor 1-like
chr3_-_26244256 2.55 ENSDART00000103741
ppp4ca
protein phosphatase 4, catalytic subunit a
chr1_-_8917902 2.53 ENSDART00000137900
grin2ab
glutamate receptor, ionotropic, N-methyl D-aspartate 2A, b
chr3_+_22335030 2.49 ENSDART00000055676
zgc:103564
zgc:103564
chr7_-_69185124 2.45 ENSDART00000182217
ENSDART00000191359
usp10
ubiquitin specific peptidase 10
chr7_-_6362460 2.44 ENSDART00000129239
hist1h2a4
histone cluster 1 H2A family member 4
chr11_+_25583950 2.44 ENSDART00000111961
ccdc120
coiled-coil domain containing 120
chr21_+_22558187 2.41 ENSDART00000167599
chek1
checkpoint kinase 1
chr15_+_44184367 2.33 ENSDART00000162918
ENSDART00000110060
zgc:165514
zgc:165514
chr5_-_4923473 2.32 ENSDART00000134585
zbtb43
zinc finger and BTB domain containing 43
chr5_+_34549365 2.26 ENSDART00000009500
aif1l
allograft inflammatory factor 1-like
chr19_-_10214264 2.19 ENSDART00000053300
ENSDART00000148225
znf865
zinc finger protein 865
chr24_+_23840821 2.19 ENSDART00000128595
ENSDART00000127188
pola1
polymerase (DNA directed), alpha 1
chr8_+_36503797 2.16 ENSDART00000184785
slc7a4
solute carrier family 7, member 4
chr5_+_69950882 2.14 ENSDART00000097359
dnajc25
DnaJ (Hsp40) homolog, subfamily C , member 25
chr11_+_18216404 2.11 ENSDART00000086437
tmcc1b
transmembrane and coiled-coil domain family 1b
chr17_+_4325693 2.10 ENSDART00000154264
mcm8
minichromosome maintenance 8 homologous recombination repair factor
chr1_+_19538299 2.10 ENSDART00000109416
smc2
structural maintenance of chromosomes 2
chr7_+_18176162 2.09 ENSDART00000109171
rce1a
Ras converting CAAX endopeptidase 1a
chr24_-_41657005 2.09 ENSDART00000159109
CABZ01044099.1

chr18_+_15271993 2.07 ENSDART00000099777
si:dkey-103i16.6
si:dkey-103i16.6
chr7_-_37895771 2.06 ENSDART00000084282
papd5
PAP associated domain containing 5
chr7_+_34236238 2.05 ENSDART00000052474
tipin
timeless interacting protein
chr2_-_57941037 2.05 ENSDART00000131420
si:dkeyp-68b7.5
si:dkeyp-68b7.5
chr25_+_30196039 1.98 ENSDART00000005299
hsd17b12a
hydroxysteroid (17-beta) dehydrogenase 12a
chr22_-_10591876 1.97 ENSDART00000105846
si:dkey-42i9.8
si:dkey-42i9.8
chr18_+_14329231 1.96 ENSDART00000151641
zgc:173742
zgc:173742
chr6_-_34838397 1.95 ENSDART00000060169
ENSDART00000169605
mier1a
mesoderm induction early response 1a, transcriptional regulator
chr8_-_1219815 1.92 ENSDART00000016800
ENSDART00000149969
znf367
zinc finger protein 367
chr12_+_17927871 1.92 ENSDART00000172062
trrap
transformation/transcription domain-associated protein
chr8_+_30112655 1.89 ENSDART00000099027
fancc
Fanconi anemia, complementation group C
chr21_+_45386033 1.86 ENSDART00000151773
jade2
jade family PHD finger 2
chr13_+_9612395 1.82 ENSDART00000136689
ENSDART00000138362
slf2
SMC5-SMC6 complex localization factor 2
chr9_+_55455801 1.79 ENSDART00000144757
ENSDART00000186543
mxra5b
matrix-remodelling associated 5b
chr19_-_29294457 1.79 ENSDART00000130815
ENSDART00000103437
e2f3
E2F transcription factor 3
chr19_+_48060464 1.78 ENSDART00000123163
zgc:85936
zgc:85936
chr5_-_33255759 1.78 ENSDART00000085531
prkaa1
protein kinase, AMP-activated, alpha 1 catalytic subunit
chr20_-_9199721 1.77 ENSDART00000064140
ylpm1
YLP motif containing 1
chr3_+_53116172 1.77 ENSDART00000115117
brd4
bromodomain containing 4
chr25_-_35047838 1.76 ENSDART00000155060
CU302436.3

chr17_+_8799451 1.73 ENSDART00000189814
ENSDART00000191577
tonsl
tonsoku-like, DNA repair protein
chr3_-_35865040 1.73 ENSDART00000102952
suz12a
SUZ12 polycomb repressive complex 2a subunit
chr18_-_12858016 1.71 ENSDART00000130343
parp12a
poly (ADP-ribose) polymerase family, member 12a
chr14_+_80685 1.71 ENSDART00000188443
stag3
stromal antigen 3
chr13_+_8255106 1.68 ENSDART00000080465
hells
helicase, lymphoid specific
chr17_+_26828027 1.67 ENSDART00000042060
jade1
jade family PHD finger 1
chr2_-_53500424 1.67 ENSDART00000037557
admp
anti-dorsalizing morphogenic protein
chr4_-_77561679 1.63 ENSDART00000180809
AL935186.9

chr13_-_14929236 1.60 ENSDART00000020576
cdc25b
cell division cycle 25B
chr7_+_71586485 1.60 ENSDART00000165582
smchd1
structural maintenance of chromosomes flexible hinge domain containing 1
chr21_-_233282 1.58 ENSDART00000157684
bxdc2
brix domain containing 2
chr5_-_22969424 1.58 ENSDART00000143869
ENSDART00000172549
si:dkey-237j10.2
si:dkey-237j10.2
chr8_-_4760723 1.57 ENSDART00000064201
cdc45
CDC45 cell division cycle 45 homolog (S. cerevisiae)
chr13_+_5013572 1.57 ENSDART00000162425
psap
prosaposin
chr25_-_34740627 1.56 ENSDART00000137665
frs2b
fibroblast growth factor receptor substrate 2b
chr14_-_31814149 1.55 ENSDART00000173393
arhgef6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr14_-_49859747 1.55 ENSDART00000169456
ENSDART00000164967
nfkb1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr20_+_39344889 1.55 ENSDART00000009164
esco2
establishment of sister chromatid cohesion N-acetyltransferase 2
chr25_+_29688671 1.52 ENSDART00000073478
brd1b
bromodomain containing 1b
chr2_+_37836821 1.51 ENSDART00000143203
parp2
poly (ADP-ribose) polymerase 2
chr2_-_38363017 1.50 ENSDART00000088026
prmt5
protein arginine methyltransferase 5
chr13_-_35908275 1.48 ENSDART00000013961
mycla
MYCL proto-oncogene, bHLH transcription factor a
chr25_+_36333993 1.48 ENSDART00000184379
CR354435.2

chr16_+_28270037 1.47 ENSDART00000059035
mindy3
MINDY lysine 48 deubiquitinase 3
chr15_+_44201056 1.47 ENSDART00000162433
ENSDART00000148336
CU655961.4

chr17_+_8799661 1.46 ENSDART00000105326
tonsl
tonsoku-like, DNA repair protein
chr8_+_20415824 1.46 ENSDART00000009081
ENSDART00000145444
mob3a
MOB kinase activator 3A
chr13_+_20524921 1.46 ENSDART00000081385
ccdc172
coiled-coil domain containing 172
chr1_-_59216197 1.45 ENSDART00000062426
lpar2b
lysophosphatidic acid receptor 2b
chr20_-_29499363 1.45 ENSDART00000152889
ENSDART00000153252
ENSDART00000170972
ENSDART00000166420
ENSDART00000163079
rrm2
ribonucleotide reductase M2 polypeptide
chr7_-_73845736 1.43 ENSDART00000193414
zgc:173552
zgc:173552
chr3_-_15679107 1.43 ENSDART00000080441
zgc:66443
zgc:66443
chr3_+_37112693 1.43 ENSDART00000055228
ENSDART00000144278
ENSDART00000138079
psmc3ip
PSMC3 interacting protein
chr2_+_8779164 1.43 ENSDART00000134308
zzz3
zinc finger, ZZ-type containing 3
chr19_-_20403318 1.41 ENSDART00000136826
dazl
deleted in azoospermia-like
chr5_+_58679071 1.38 ENSDART00000019561
zgc:171734
zgc:171734
chr21_-_19915757 1.37 ENSDART00000164317
eri1
exoribonuclease 1
chr17_-_26537928 1.34 ENSDART00000155692
ENSDART00000122366
ccser2a
coiled-coil serine-rich protein 2a
chr22_-_5822147 1.33 ENSDART00000011076
cers5
ceramide synthase 5
chr18_+_41560822 1.30 ENSDART00000158503
baz1b
bromodomain adjacent to zinc finger domain, 1B
chr19_-_2582858 1.28 ENSDART00000113829
cdca7b
cell division cycle associated 7b
chr7_+_24814866 1.28 ENSDART00000173581
si:ch211-226l4.6
si:ch211-226l4.6
chr20_-_44576949 1.27 ENSDART00000148639
ubxn2a
UBX domain protein 2A
chr25_-_35144620 1.26 ENSDART00000185669
hist1h2a2
histone cluster 1 H2A family member 2
chr25_-_13403726 1.25 ENSDART00000056723
gins3
GINS complex subunit 3
chr18_+_41561285 1.25 ENSDART00000169621
baz1b
bromodomain adjacent to zinc finger domain, 1B
chr13_+_33462232 1.25 ENSDART00000177841
zgc:136302
zgc:136302
chr10_+_21434649 1.25 ENSDART00000193938
ENSDART00000064558
etf1b
eukaryotic translation termination factor 1b
chr13_+_31402067 1.25 ENSDART00000019202
tdrd9
tudor domain containing 9
chr16_+_11188810 1.23 ENSDART00000186011
cicb
capicua transcriptional repressor b
chr8_-_24791060 1.23 ENSDART00000111617
rbm15
RNA binding motif protein 15
chr20_+_41801913 1.23 ENSDART00000139805
mcm9
minichromosome maintenance 9 homologous recombination repair factor
chr12_+_9183626 1.22 ENSDART00000020192
tubgcp2
tubulin, gamma complex associated protein 2
chr13_-_35907768 1.21 ENSDART00000147522
mycla
MYCL proto-oncogene, bHLH transcription factor a
chr14_-_35400671 1.20 ENSDART00000129676
lsm11
LSM11, U7 small nuclear RNA associated
chr24_-_37338739 1.20 ENSDART00000146844
tsr3
TSR3, 20S rRNA accumulation, homolog (S. cerevisiae)
chr4_-_15003854 1.18 ENSDART00000134701
ENSDART00000002401
klhdc10
kelch domain containing 10
chr2_-_44777592 1.18 ENSDART00000113351
ENSDART00000169310
ncapd2
non-SMC condensin I complex, subunit D2
chr10_-_20588787 1.18 ENSDART00000138045
ENSDART00000181885
ENSDART00000091115
nsd3
nuclear receptor binding SET domain protein 3
chr25_-_35095129 1.15 ENSDART00000099866
ENSDART00000099868
kif15
kinesin family member 15
chr21_-_19916021 1.14 ENSDART00000065671
eri1
exoribonuclease 1
chr17_-_33707589 1.14 ENSDART00000124788
si:dkey-84k17.2
si:dkey-84k17.2
chr20_-_38827623 1.14 ENSDART00000153310
cad
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
chr7_+_71535045 1.14 ENSDART00000047069
tyms
thymidylate synthetase
chr3_-_34528306 1.13 ENSDART00000023039
sept9a
septin 9a
chr20_-_29498178 1.13 ENSDART00000152986
ENSDART00000027851
ENSDART00000152954
rrm2
ribonucleotide reductase M2 polypeptide
chr14_-_30918662 1.13 ENSDART00000176631
si:ch211-126c2.4
si:ch211-126c2.4
chr5_+_20453874 1.12 ENSDART00000124545
ENSDART00000008402
sart3
squamous cell carcinoma antigen recognized by T cells 3
chr16_-_43335914 1.12 ENSDART00000111963
atad2
ATPase family, AAA domain containing 2
chr2_-_44344321 1.11 ENSDART00000084174
lig1
ligase I, DNA, ATP-dependent
chr25_-_35140746 1.10 ENSDART00000129969
si:ch211-113a14.19
si:ch211-113a14.19
chr23_-_45339439 1.09 ENSDART00000148726
ccdc171
coiled-coil domain containing 171
chr4_+_18441988 1.09 ENSDART00000040827
ncaph2
non-SMC condensin II complex, subunit H2
chr7_+_19851422 1.09 ENSDART00000142970
ENSDART00000190027
mus81
MUS81 structure-specific endonuclease subunit
chr23_-_17003533 1.09 ENSDART00000080545
dnmt3bb.2
DNA (cytosine-5-)-methyltransferase 3 beta, duplicate b.2
chr14_-_31715373 1.08 ENSDART00000127303
ENSDART00000173274
ENSDART00000173435
ENSDART00000172876
ENSDART00000173036
map7d3
MAP7 domain containing 3
chr24_-_11908115 1.08 ENSDART00000184329
tm9sf1
transmembrane 9 superfamily member 1
chr25_-_32363341 1.07 ENSDART00000153892
ENSDART00000114385
cep152
centrosomal protein 152
chr16_+_41015781 1.07 ENSDART00000124543
dek
DEK proto-oncogene
chr5_+_12743640 1.06 ENSDART00000081411
pole
polymerase (DNA directed), epsilon
chr17_-_22573311 1.06 ENSDART00000141523
ENSDART00000140022
ENSDART00000079390
ENSDART00000188644
exo1
exonuclease 1
chr20_-_33487729 1.06 ENSDART00000061843
smek1
SMEK homolog 1, suppressor of mek1 (Dictyostelium)
chr17_+_18810904 1.05 ENSDART00000130899
si:dkey-288a3.2
si:dkey-288a3.2
chr21_-_30032706 1.05 ENSDART00000156721
pwwp2a
PWWP domain containing 2A
chr2_-_48375342 1.04 ENSDART00000148788
per2
period circadian clock 2
chr2_+_11119315 1.04 ENSDART00000055737
tyw3
tRNA-yW synthesizing protein 3 homolog (S. cerevisiae)
chr12_-_33817114 1.04 ENSDART00000161265
twnk
twinkle mtDNA helicase
chr4_+_69888328 1.04 ENSDART00000170163
si:ch211-145h19.5
si:ch211-145h19.5
chr6_+_50451337 1.04 ENSDART00000155051
mych
myelocytomatosis oncogene homolog
chr20_+_38201644 1.03 ENSDART00000022694
ehd3
EH-domain containing 3
chr18_-_20532339 1.03 ENSDART00000060291
ighmbp2
immunoglobulin mu binding protein 2
chr5_-_20491198 0.99 ENSDART00000183051
ENSDART00000144232
ficd
FIC domain containing
chr7_+_5956937 0.99 ENSDART00000170763
hist1h2a4
histone cluster 1 H2A family member 4
chr19_-_20777351 0.99 ENSDART00000019206
ngly1
N-glycanase 1
chr25_-_35145920 0.99 ENSDART00000157137
si:dkey-261m9.19
si:dkey-261m9.19
chr19_-_47571456 0.99 ENSDART00000158071
ENSDART00000165841
rrm2
ribonucleotide reductase M2 polypeptide
chr1_+_27690 0.98 ENSDART00000162928
eed
embryonic ectoderm development
chr7_+_5908077 0.96 ENSDART00000173404
hist1h2a4
histone cluster 1 H2A family member 4
chr21_-_30031396 0.95 ENSDART00000157167
pwwp2a
PWWP domain containing 2A
chr21_+_233271 0.95 ENSDART00000171440
dtwd2
DTW domain containing 2
chr7_+_24023653 0.95 ENSDART00000141165
tinf2
TERF1 (TRF1)-interacting nuclear factor 2
chr15_-_1584137 0.94 ENSDART00000056772
trim59
tripartite motif containing 59
chr2_+_21000334 0.93 ENSDART00000062563
ENSDART00000147809
rreb1b
ras responsive element binding protein 1b
chr7_+_67748939 0.93 ENSDART00000162978
dhx38
DEAH (Asp-Glu-Ala-His) box polypeptide 38
chr7_-_60351876 0.93 ENSDART00000098563
plcb3
phospholipase C, beta 3 (phosphatidylinositol-specific)
chr21_-_13055195 0.93 ENSDART00000133517
myorg
myogenesis regulating glycosidase (putative)
chr18_-_46183462 0.92 ENSDART00000021192
kcnk6
potassium channel, subfamily K, member 6
chr10_+_9595575 0.92 ENSDART00000091780
ENSDART00000184287
rc3h2
ring finger and CCCH-type domains 2
chr12_-_6880694 0.90 ENSDART00000171846
pcdh15b
protocadherin-related 15b
chr15_-_7337148 0.90 ENSDART00000182568
SLC7A1 (1 of many)
high affinity cationic amino acid transporter 1
chr7_-_40657831 0.90 ENSDART00000084153
nom1
nucleolar protein with MIF4G domain 1
chr5_+_51248784 0.90 ENSDART00000159571
ENSDART00000189513
ENSDART00000092285
msh3
mutS homolog 3 (E. coli)
chr9_+_29431763 0.90 ENSDART00000186095
ENSDART00000182640
uggt2
UDP-glucose glycoprotein glucosyltransferase 2
chr8_-_25761544 0.89 ENSDART00000078152
suv39h1b
suppressor of variegation 3-9 homolog 1b
chr8_+_36509885 0.89 ENSDART00000109530
slc7a4
solute carrier family 7, member 4
chr24_+_17345521 0.88 ENSDART00000024722
ENSDART00000154250
ezh2
enhancer of zeste 2 polycomb repressive complex 2 subunit
chr1_+_26677406 0.88 ENSDART00000183427
ENSDART00000180366
ENSDART00000181997
si:dkey-25o16.4
si:dkey-25o16.4
chr20_+_44582318 0.88 ENSDART00000149000
ENSDART00000149775
ENSDART00000085416
atad2b
ATPase family, AAA domain containing 2B
chr7_-_7797654 0.87 ENSDART00000084503
ENSDART00000192779
ENSDART00000173079
trmt10b
tRNA methyltransferase 10B
chr19_-_4840688 0.87 ENSDART00000193855
fbxl20
F-box and leucine-rich repeat protein 20
chr7_-_73854476 0.86 ENSDART00000186481
zgc:173552
zgc:173552
chr15_-_4124099 0.86 ENSDART00000185583
rnf168
ring finger protein 168
chr21_-_40562705 0.85 ENSDART00000158289
ENSDART00000171997
taok1b
TAO kinase 1b
chr25_-_35112466 0.85 ENSDART00000183481
CU302436.4

chr5_+_27488975 0.85 ENSDART00000123635
sfrp1a
secreted frizzled-related protein 1a
chr6_-_33931696 0.84 ENSDART00000057290
prpf38a
pre-mRNA processing factor 38A
chr13_+_46803979 0.84 ENSDART00000159260
CU695232.1

chr23_+_45339684 0.84 ENSDART00000149410
ENSDART00000102441
psip1b
PC4 and SFRS1 interacting protein 1b
chr4_-_5831522 0.83 ENSDART00000008898
foxm1
forkhead box M1
chr9_+_22466218 0.82 ENSDART00000131214
dgkg
diacylglycerol kinase, gamma
chr1_+_9199031 0.82 ENSDART00000092058
ENSDART00000182771
chtf18
CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)

Network of associatons between targets according to the STRING database.

First level regulatory network of e2f2_e2f5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.6 GO:1901993 meiotic cell cycle phase transition(GO:0044771) metaphase/anaphase transition of meiotic cell cycle(GO:0044785) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994) regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902102) negative regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902103) regulation of meiotic chromosome separation(GO:1905132) negative regulation of meiotic chromosome separation(GO:1905133)
1.3 10.5 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
1.3 6.4 GO:0032776 DNA methylation on cytosine(GO:0032776)
1.2 3.7 GO:0097676 histone H3-K36 dimethylation(GO:0097676)
0.9 0.9 GO:0043111 replication fork arrest(GO:0043111)
0.8 5.9 GO:0000076 DNA replication checkpoint(GO:0000076)
0.8 3.2 GO:0006272 leading strand elongation(GO:0006272)
0.7 2.1 GO:0080120 CAAX-box protein processing(GO:0071586) CAAX-box protein maturation(GO:0080120)
0.7 4.1 GO:0060149 negative regulation of posttranscriptional gene silencing(GO:0060149) negative regulation of gene silencing by miRNA(GO:0060965) negative regulation of gene silencing by RNA(GO:0060967)
0.7 7.4 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.6 1.9 GO:1903003 positive regulation of protein deubiquitination(GO:1903003)
0.6 5.3 GO:0044030 regulation of DNA methylation(GO:0044030)
0.6 1.8 GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407)
0.6 2.3 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.6 1.7 GO:0060063 Spemann organizer formation at the embryonic shield(GO:0060063)
0.5 1.6 GO:0035751 regulation of lysosomal lumen pH(GO:0035751)
0.5 4.2 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.5 1.6 GO:0034421 post-translational protein acetylation(GO:0034421)
0.5 2.5 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.5 1.5 GO:0034969 histone arginine methylation(GO:0034969)
0.4 2.2 GO:0045448 regulation of mitotic cell cycle, embryonic(GO:0009794) mitotic cell cycle, embryonic(GO:0045448)
0.4 4.8 GO:0030719 P granule organization(GO:0030719)
0.4 3.0 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.4 3.5 GO:0043982 histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.4 1.1 GO:0021563 glossopharyngeal nerve development(GO:0021563)
0.3 1.6 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.3 2.2 GO:0033567 DNA replication, Okazaki fragment processing(GO:0033567)
0.3 0.9 GO:0070734 histone H3-K27 methylation(GO:0070734)
0.3 2.8 GO:0061588 calcium activated phospholipid scrambling(GO:0061588)
0.2 1.2 GO:0002184 cytoplasmic translational termination(GO:0002184)
0.2 1.2 GO:0043046 DNA methylation involved in gamete generation(GO:0043046)
0.2 4.9 GO:0097178 ruffle assembly(GO:0097178)
0.2 0.7 GO:0016446 somatic diversification of immune receptors via somatic mutation(GO:0002566) pyrimidine dimer repair(GO:0006290) somatic hypermutation of immunoglobulin genes(GO:0016446)
0.2 8.5 GO:0048538 thymus development(GO:0048538)
0.2 1.1 GO:0098535 de novo centriole assembly(GO:0098535)
0.2 2.5 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.2 0.6 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.2 1.2 GO:0000455 enzyme-directed rRNA pseudouridine synthesis(GO:0000455)
0.2 1.4 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.2 3.3 GO:0032508 DNA geometric change(GO:0032392) DNA duplex unwinding(GO:0032508)
0.2 0.8 GO:0060339 negative regulation of type I interferon-mediated signaling pathway(GO:0060339)
0.2 1.1 GO:0031573 intra-S DNA damage checkpoint(GO:0031573)
0.2 3.6 GO:0031297 replication fork processing(GO:0031297)
0.2 1.6 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.2 0.9 GO:0090646 mitochondrial tRNA processing(GO:0090646)
0.2 1.0 GO:0042753 positive regulation of circadian rhythm(GO:0042753)
0.2 10.5 GO:0000723 telomere maintenance(GO:0000723) telomere organization(GO:0032200)
0.2 1.3 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.2 0.8 GO:0060019 radial glial cell differentiation(GO:0060019)
0.1 0.6 GO:0044210 'de novo' CTP biosynthetic process(GO:0044210)
0.1 1.0 GO:0006264 mitochondrial DNA replication(GO:0006264)
0.1 3.0 GO:0060969 negative regulation of gene silencing(GO:0060969)
0.1 0.7 GO:0000012 single strand break repair(GO:0000012)
0.1 0.6 GO:0071169 establishment of protein localization to chromosome(GO:0070199) establishment of protein localization to chromatin(GO:0071169)
0.1 0.6 GO:0070272 proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.1 1.1 GO:0051673 membrane disruption in other organism(GO:0051673)
0.1 2.5 GO:0060079 excitatory postsynaptic potential(GO:0060079)
0.1 0.8 GO:0040016 embryonic cleavage(GO:0040016)
0.1 0.9 GO:0045190 B cell activation involved in immune response(GO:0002312) isotype switching(GO:0045190)
0.1 1.5 GO:0044154 histone H3-K14 acetylation(GO:0044154)
0.1 2.1 GO:0030261 chromosome condensation(GO:0030261)
0.1 0.6 GO:0060049 regulation of protein glycosylation(GO:0060049)
0.1 2.0 GO:0006265 DNA topological change(GO:0006265)
0.1 0.6 GO:0030219 megakaryocyte differentiation(GO:0030219)
0.1 0.2 GO:0007100 mitotic centrosome separation(GO:0007100) centrosome separation(GO:0051299)
0.1 2.5 GO:0006270 DNA replication initiation(GO:0006270)
0.1 1.0 GO:0006517 protein deglycosylation(GO:0006517)
0.1 2.6 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.1 0.7 GO:0072386 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.1 0.7 GO:2000725 regulation of cardiocyte differentiation(GO:1905207) regulation of cardiac muscle cell differentiation(GO:2000725)
0.1 0.6 GO:0033278 cell proliferation in midbrain(GO:0033278)
0.1 0.8 GO:0006167 AMP biosynthetic process(GO:0006167)
0.1 1.6 GO:0006298 mismatch repair(GO:0006298)
0.1 1.9 GO:0035675 neuromast hair cell development(GO:0035675)
0.1 3.6 GO:0007062 sister chromatid cohesion(GO:0007062)
0.1 1.9 GO:0036297 interstrand cross-link repair(GO:0036297)
0.1 0.9 GO:0050962 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.1 1.4 GO:0043967 histone H4 acetylation(GO:0043967)
0.1 1.3 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.1 0.1 GO:0042148 strand invasion(GO:0042148)
0.1 3.0 GO:0006342 chromatin silencing(GO:0006342)
0.1 0.2 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.1 0.7 GO:0002154 thyroid hormone mediated signaling pathway(GO:0002154)
0.1 0.4 GO:0048260 positive regulation of receptor-mediated endocytosis(GO:0048260) protein localization to early endosome(GO:1902946)
0.1 1.6 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.1 0.5 GO:0021634 optic nerve formation(GO:0021634)
0.1 1.4 GO:0007020 microtubule nucleation(GO:0007020)
0.1 1.5 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.1 0.4 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.1 0.9 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.1 0.8 GO:0071156 regulation of cell cycle arrest(GO:0071156)
0.1 0.7 GO:0019985 translesion synthesis(GO:0019985)
0.1 1.5 GO:2000779 regulation of double-strand break repair(GO:2000779)
0.1 1.4 GO:0016925 protein sumoylation(GO:0016925)
0.1 0.4 GO:0030643 microglia differentiation(GO:0014004) cellular anion homeostasis(GO:0030002) cellular monovalent inorganic anion homeostasis(GO:0030320) cellular phosphate ion homeostasis(GO:0030643) cellular divalent inorganic anion homeostasis(GO:0072501) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.1 0.9 GO:0043114 regulation of vascular permeability(GO:0043114)
0.1 1.4 GO:0007131 reciprocal meiotic recombination(GO:0007131)
0.0 0.5 GO:0070836 membrane raft assembly(GO:0001765) plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) caveola assembly(GO:0070836)
0.0 0.2 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.0 0.3 GO:0006004 fucose metabolic process(GO:0006004)
0.0 9.7 GO:0006281 DNA repair(GO:0006281)
0.0 0.5 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.0 1.0 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.0 1.2 GO:0060319 primitive erythrocyte differentiation(GO:0060319)
0.0 0.5 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.0 0.1 GO:0030299 intestinal cholesterol absorption(GO:0030299)
0.0 0.6 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.0 0.4 GO:0071941 nitrogen cycle metabolic process(GO:0071941)
0.0 2.3 GO:0035567 non-canonical Wnt signaling pathway(GO:0035567)
0.0 0.7 GO:0021554 optic nerve development(GO:0021554)
0.0 0.9 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.8 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 1.9 GO:0016575 histone deacetylation(GO:0016575)
0.0 0.9 GO:0097194 execution phase of apoptosis(GO:0097194)
0.0 1.7 GO:0070304 positive regulation of stress-activated MAPK cascade(GO:0032874) positive regulation of stress-activated protein kinase signaling cascade(GO:0070304)
0.0 2.4 GO:0006334 nucleosome assembly(GO:0006334)
0.0 1.0 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.3 GO:0042144 vacuole fusion, non-autophagic(GO:0042144)
0.0 3.0 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.6 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)
0.0 0.8 GO:0060972 left/right pattern formation(GO:0060972)
0.0 0.1 GO:0098908 regulation of neuronal action potential(GO:0098908)
0.0 0.2 GO:0031060 regulation of histone methylation(GO:0031060)
0.0 0.7 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.0 0.3 GO:1902624 positive regulation of neutrophil migration(GO:1902624)
0.0 0.7 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.0 0.3 GO:0019885 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0 0.2 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 0.2 GO:0006704 glucocorticoid biosynthetic process(GO:0006704) cortisol metabolic process(GO:0034650)
0.0 1.8 GO:0051090 regulation of sequence-specific DNA binding transcription factor activity(GO:0051090)
0.0 0.9 GO:0034968 histone lysine methylation(GO:0034968)
0.0 0.1 GO:0019464 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.0 0.2 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.0 2.2 GO:0006338 chromatin remodeling(GO:0006338)
0.0 1.0 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.2 GO:0072576 liver morphogenesis(GO:0072576)
0.0 0.5 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 0.2 GO:0015800 acidic amino acid transport(GO:0015800) aspartate transport(GO:0015810) L-glutamate transport(GO:0015813) malate-aspartate shuttle(GO:0043490)
0.0 0.8 GO:0007006 mitochondrial membrane organization(GO:0007006)
0.0 1.1 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 1.6 GO:0019216 regulation of lipid metabolic process(GO:0019216)
0.0 0.3 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.0 0.9 GO:0043488 regulation of mRNA stability(GO:0043488)
0.0 0.5 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.0 0.1 GO:0070084 protein initiator methionine removal(GO:0070084)
0.0 0.7 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.0 0.2 GO:0000272 polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.0 0.3 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.4 GO:0007093 mitotic cell cycle checkpoint(GO:0007093)
0.0 1.1 GO:0061640 cytoskeleton-dependent cytokinesis(GO:0061640)
0.0 0.2 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
0.0 0.8 GO:0006119 oxidative phosphorylation(GO:0006119)
0.0 0.5 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 0.2 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.0 0.4 GO:0016441 posttranscriptional gene silencing(GO:0016441) posttranscriptional gene silencing by RNA(GO:0035194)
0.0 1.0 GO:0008033 tRNA processing(GO:0008033)
0.0 1.7 GO:0032259 methylation(GO:0032259)
0.0 1.3 GO:0006413 translational initiation(GO:0006413)
0.0 0.8 GO:0008203 cholesterol metabolic process(GO:0008203)
0.0 0.5 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 0.7 GO:0031929 TOR signaling(GO:0031929)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.8 GO:0033391 chromatoid body(GO:0033391)
1.0 12.3 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.6 1.9 GO:0098536 deuterosome(GO:0098536)
0.6 4.3 GO:0005662 DNA replication factor A complex(GO:0005662)
0.5 2.4 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.4 2.5 GO:0031261 DNA replication preinitiation complex(GO:0031261)
0.4 2.0 GO:0031298 replication fork protection complex(GO:0031298)
0.4 1.2 GO:0008275 gamma-tubulin small complex(GO:0008275)
0.3 1.1 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.3 3.7 GO:0000792 heterochromatin(GO:0000792)
0.2 1.2 GO:0018444 translation release factor complex(GO:0018444)
0.2 0.7 GO:0032301 MutSalpha complex(GO:0032301)
0.2 0.8 GO:0045293 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.2 1.1 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.2 1.9 GO:0000124 SAGA complex(GO:0000124)
0.2 2.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.2 1.8 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.2 1.4 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.2 0.8 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.1 0.6 GO:0097268 cytoophidium(GO:0097268)
0.1 0.7 GO:1990131 EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.1 1.1 GO:0000796 condensin complex(GO:0000796)
0.1 4.7 GO:0000781 chromosome, telomeric region(GO:0000781)
0.1 0.9 GO:0032300 mismatch repair complex(GO:0032300)
0.1 0.5 GO:0031510 SUMO activating enzyme complex(GO:0031510)
0.1 0.6 GO:0030870 Mre11 complex(GO:0030870)
0.1 0.3 GO:0033186 CAF-1 complex(GO:0033186)
0.1 1.4 GO:0034361 very-low-density lipoprotein particle(GO:0034361)
0.1 1.4 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 4.6 GO:0032587 ruffle membrane(GO:0032587)
0.1 0.4 GO:0030896 checkpoint clamp complex(GO:0030896)
0.1 0.8 GO:0071005 U2-type precatalytic spliceosome(GO:0071005)
0.1 2.2 GO:0008278 cohesin complex(GO:0008278)
0.1 2.1 GO:0035102 PRC1 complex(GO:0035102)
0.1 1.5 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.1 0.7 GO:0035101 FACT complex(GO:0035101)
0.1 7.9 GO:0044815 DNA packaging complex(GO:0044815)
0.1 0.2 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.1 1.1 GO:0015030 Cajal body(GO:0015030)
0.1 1.4 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 0.3 GO:0005879 axonemal microtubule(GO:0005879)
0.1 4.1 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.1 1.7 GO:0043186 P granule(GO:0043186)
0.1 0.3 GO:0033263 CORVET complex(GO:0033263)
0.0 0.2 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.0 1.0 GO:0060170 ciliary membrane(GO:0060170)
0.0 0.6 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.9 GO:0032420 stereocilium(GO:0032420)
0.0 0.9 GO:0035861 site of double-strand break(GO:0035861)
0.0 10.4 GO:0005730 nucleolus(GO:0005730)
0.0 1.1 GO:0005940 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 0.1 GO:0005960 glycine cleavage complex(GO:0005960)
0.0 0.2 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.3 GO:0043596 nuclear replication fork(GO:0043596)
0.0 0.9 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 1.0 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.9 GO:0016605 PML body(GO:0016605)
0.0 0.2 GO:0031931 TORC1 complex(GO:0031931)
0.0 1.2 GO:0000779 condensed chromosome, centromeric region(GO:0000779)
0.0 1.0 GO:0000775 chromosome, centromeric region(GO:0000775)
0.0 0.2 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.1 GO:1990130 Iml1 complex(GO:1990130)
0.0 1.8 GO:0030027 lamellipodium(GO:0030027)
0.0 5.2 GO:0005694 chromosome(GO:0005694)
0.0 0.5 GO:0016514 SWI/SNF complex(GO:0016514)
0.0 0.9 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.7 GO:0030532 small nuclear ribonucleoprotein complex(GO:0030532)
0.0 0.6 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.2 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.1 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.6 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.8 GO:0070182 DNA polymerase binding(GO:0070182)
0.9 6.2 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.9 4.4 GO:0009374 biotin binding(GO:0009374)
0.5 1.5 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.5 6.4 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.5 4.1 GO:0008494 translation activator activity(GO:0008494)
0.4 1.2 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.4 10.1 GO:0003688 DNA replication origin binding(GO:0003688)
0.4 1.6 GO:0032135 DNA insertion or deletion binding(GO:0032135)
0.4 1.1 GO:0016743 carboxyl- or carbamoyltransferase activity(GO:0016743)
0.4 1.1 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.4 2.5 GO:0035173 histone kinase activity(GO:0035173)
0.4 1.8 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.4 1.4 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
0.4 1.1 GO:0045145 single-stranded DNA 5'-3' exodeoxyribonuclease activity(GO:0045145)
0.3 2.8 GO:0009378 four-way junction helicase activity(GO:0009378)
0.3 4.9 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.3 0.8 GO:0071077 coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)
0.3 0.8 GO:0001734 mRNA (N6-adenosine)-methyltransferase activity(GO:0001734)
0.3 1.1 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.3 2.8 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.2 1.5 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.2 0.9 GO:0052905 tRNA (guanine(9)-N(1))-methyltransferase activity(GO:0052905)
0.2 2.1 GO:0048256 flap endonuclease activity(GO:0048256)
0.2 2.5 GO:1990404 protein ADP-ribosylase activity(GO:1990404)
0.2 1.0 GO:0043139 5'-3' DNA helicase activity(GO:0043139)
0.2 0.8 GO:0017116 single-stranded DNA-dependent ATP-dependent DNA helicase activity(GO:0017116) single-stranded DNA-dependent ATPase activity(GO:0043142)
0.2 0.9 GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980)
0.2 1.3 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.2 1.1 GO:0017070 U6 snRNA binding(GO:0017070)
0.2 0.9 GO:0035613 RNA stem-loop binding(GO:0035613)
0.2 2.0 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.1 0.6 GO:0003883 CTP synthase activity(GO:0003883)
0.1 0.4 GO:0032574 5'-3' RNA helicase activity(GO:0032574)
0.1 2.1 GO:0070403 NAD+ binding(GO:0070403)
0.1 0.4 GO:0015562 inositol hexakisphosphate binding(GO:0000822) efflux transmembrane transporter activity(GO:0015562)
0.1 1.8 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 1.0 GO:0001222 transcription corepressor binding(GO:0001222)
0.1 0.4 GO:0047777 (3S)-citramalyl-CoA lyase activity(GO:0047777)
0.1 2.5 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.1 0.5 GO:0019948 SUMO activating enzyme activity(GO:0019948)
0.1 1.2 GO:1904047 S-adenosyl-L-methionine binding(GO:1904047)
0.1 1.5 GO:0043994 H3 histone acetyltransferase activity(GO:0010484) histone acetyltransferase activity (H3-K23 specific)(GO:0043994)
0.1 1.4 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 0.9 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.1 0.5 GO:0008432 JUN kinase binding(GO:0008432)
0.1 0.3 GO:0042806 fucose binding(GO:0042806)
0.1 1.7 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 1.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 1.3 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.1 0.6 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.1 0.2 GO:0000150 recombinase activity(GO:0000150)
0.1 2.5 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.1 1.2 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 1.9 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 0.2 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.1 2.9 GO:0042054 histone methyltransferase activity(GO:0042054)
0.1 0.4 GO:0050699 WW domain binding(GO:0050699)
0.1 13.5 GO:0042393 histone binding(GO:0042393)
0.1 0.7 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 0.8 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 2.3 GO:0003684 damaged DNA binding(GO:0003684)
0.1 0.8 GO:0061665 SUMO ligase activity(GO:0061665)
0.1 0.4 GO:0098809 nitrite reductase activity(GO:0098809)
0.1 1.4 GO:0000339 RNA cap binding(GO:0000339)
0.1 1.0 GO:0070566 adenylyltransferase activity(GO:0070566)
0.1 0.5 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.0 1.2 GO:0017069 snRNA binding(GO:0017069)
0.0 0.2 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.0 0.8 GO:0031386 protein tag(GO:0031386)
0.0 0.8 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.5 GO:0005042 netrin receptor activity(GO:0005042)
0.0 0.4 GO:0004067 asparaginase activity(GO:0004067)
0.0 0.5 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.5 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 1.0 GO:0004812 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.0 0.6 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 0.2 GO:0008184 phosphorylase activity(GO:0004645) glycogen phosphorylase activity(GO:0008184)
0.0 0.3 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.0 1.6 GO:0008094 DNA-dependent ATPase activity(GO:0008094)
0.0 0.1 GO:0061656 SUMO conjugating enzyme activity(GO:0061656)
0.0 0.9 GO:0022842 leak channel activity(GO:0022840) potassium ion leak channel activity(GO:0022841) narrow pore channel activity(GO:0022842)
0.0 0.8 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.6 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.9 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 1.0 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.0 0.3 GO:0004977 melanocortin receptor activity(GO:0004977)
0.0 0.8 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 4.5 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 2.2 GO:0003724 RNA helicase activity(GO:0003724)
0.0 2.6 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.4 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 2.4 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.3 GO:0016405 CoA-ligase activity(GO:0016405)
0.0 0.9 GO:0004629 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.0 2.0 GO:0043130 ubiquitin binding(GO:0043130)
0.0 1.0 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 1.0 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 5.5 GO:0003682 chromatin binding(GO:0003682)
0.0 0.4 GO:0008408 3'-5' exonuclease activity(GO:0008408)
0.0 2.3 GO:0004519 endonuclease activity(GO:0004519)
0.0 4.5 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 0.2 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.0 0.3 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 1.6 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.3 GO:0031682 G-protein gamma-subunit binding(GO:0031682)
0.0 1.4 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.0 0.2 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.0 0.8 GO:0016879 ligase activity, forming carbon-nitrogen bonds(GO:0016879)
0.0 0.9 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.9 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 1.6 GO:0008168 methyltransferase activity(GO:0008168)
0.0 1.0 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 0.7 GO:0019903 protein phosphatase binding(GO:0019903)
0.0 4.0 GO:0051015 actin filament binding(GO:0051015)
0.0 3.3 GO:0003712 transcription factor activity, transcription factor binding(GO:0000989) transcription cofactor activity(GO:0003712)
0.0 9.5 GO:0004674 protein serine/threonine kinase activity(GO:0004674)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 4.4 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2 10.3 PID ATR PATHWAY ATR signaling pathway
0.2 6.2 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.1 5.5 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.1 3.2 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.1 2.5 PID BARD1 PATHWAY BARD1 signaling events
0.1 1.0 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.1 1.8 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.1 3.1 PID TELOMERASE PATHWAY Regulation of Telomerase
0.1 0.9 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.1 1.4 PID REELIN PATHWAY Reelin signaling pathway
0.1 0.6 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 1.9 PID MYC PATHWAY C-MYC pathway
0.1 2.3 PID AURORA B PATHWAY Aurora B signaling
0.1 2.9 PID E2F PATHWAY E2F transcription factor network
0.1 0.8 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.1 1.8 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.1 1.6 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 1.7 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.4 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.4 PID FAS PATHWAY FAS (CD95) signaling pathway
0.0 1.1 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.0 0.7 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 0.2 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.0 0.9 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.4 PID P53 REGULATION PATHWAY p53 pathway
0.0 0.6 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 0.4 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 23.6 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.7 15.0 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.3 1.8 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.3 2.8 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.2 2.2 REACTOME EARLY PHASE OF HIV LIFE CYCLE Genes involved in Early Phase of HIV Life Cycle
0.2 1.6 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.2 1.2 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.2 0.9 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 1.1 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.1 0.7 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.1 1.9 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.1 1.6 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 1.2 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.1 0.9 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 0.9 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.1 2.7 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.1 0.9 REACTOME E2F MEDIATED REGULATION OF DNA REPLICATION Genes involved in E2F mediated regulation of DNA replication
0.1 0.5 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 1.1 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.1 1.2 REACTOME KINESINS Genes involved in Kinesins
0.1 1.5 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.1 0.9 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 0.8 REACTOME DOUBLE STRAND BREAK REPAIR Genes involved in Double-Strand Break Repair
0.0 1.3 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.6 REACTOME SPHINGOLIPID METABOLISM Genes involved in Sphingolipid metabolism
0.0 1.1 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.0 1.0 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.8 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 1.6 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.0 0.4 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.6 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.7 REACTOME ELONGATION ARREST AND RECOVERY Genes involved in Elongation arrest and recovery
0.0 0.8 REACTOME TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER Genes involved in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
0.0 0.2 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.7 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.7 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.2 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.2 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway