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PRJNA195909:zebrafish embryo and larva development

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Results for e2f4

Z-value: 1.43

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Transcription factors associated with e2f4

Gene Symbol Gene ID Gene Info
e2f4
ENSDARG00000101578 E2F transcription factor 4
e2f4
ENSDARG00000109320 E2F transcription factor 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
e2f4dr11_v1_chr25_+_17405201_174052010.752.0e-02Click!

Activity profile of e2f4 motif

Sorted Z-values of e2f4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_+_6884123 3.09 ENSDART00000149095
ENSDART00000148772
ENSDART00000149334
ddx4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
chr7_+_24814866 2.88 ENSDART00000173581
si:ch211-226l4.6
si:ch211-226l4.6
chr20_+_35445462 2.72 ENSDART00000124497
tdrd6
tudor domain containing 6
chr25_+_35155676 2.09 ENSDART00000114598
zgc:112234
zgc:112234
chr3_-_7897563 1.99 ENSDART00000185232
ubn2b
ubinuclein 2b
chr3_-_7897305 1.99 ENSDART00000169757
ubn2b
ubinuclein 2b
chr5_+_20453874 1.90 ENSDART00000124545
ENSDART00000008402
sart3
squamous cell carcinoma antigen recognized by T cells 3
chr25_-_36370292 1.84 ENSDART00000152766
CR354435.1
Histone H2B 1/2
chr7_+_5960491 1.82 ENSDART00000145370
zgc:112234
zgc:112234
chr23_-_19831739 1.73 ENSDART00000125066
haus7
HAUS augmin-like complex, subunit 7
chr20_-_29498178 1.66 ENSDART00000152986
ENSDART00000027851
ENSDART00000152954
rrm2
ribonucleotide reductase M2 polypeptide
chr11_+_31680513 1.54 ENSDART00000139900
ENSDART00000040305
diaph3
diaphanous-related formin 3
chr23_-_45568816 1.54 ENSDART00000076086
cyp17a2
cytochrome P450, family 17, subfamily A, polypeptide 2
chr15_-_23936276 1.52 ENSDART00000137569
appbp2
amyloid beta precursor protein (cytoplasmic tail) binding protein 2
chr7_-_6429031 1.46 ENSDART00000173413
zgc:112234
zgc:112234
chr7_-_50633285 1.42 ENSDART00000174018
crtc3
CREB regulated transcription coactivator 3
chr7_-_73854476 1.37 ENSDART00000186481
zgc:173552
zgc:173552
chr10_+_6010570 1.36 ENSDART00000190025
ENSDART00000163680
hmgcs1
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chr7_+_24881680 1.27 ENSDART00000058843
krcp
kelch repeat-containing protein
chr20_-_28433990 1.24 ENSDART00000182824
ENSDART00000193381
wdr21
WD repeat domain 21
chr7_-_6459481 1.24 ENSDART00000173158
zgc:112234
zgc:112234
chr17_-_11368662 1.21 ENSDART00000159061
ENSDART00000188694
ENSDART00000190932
si:ch211-185a18.2
si:ch211-185a18.2
chr20_+_33994580 1.14 ENSDART00000061729
si:dkey-97o5.1
si:dkey-97o5.1
chr20_-_28433616 1.13 ENSDART00000169289
wdr21
WD repeat domain 21
chr17_-_15189397 1.05 ENSDART00000133710
ENSDART00000110507
wdhd1
WD repeat and HMG-box DNA binding protein 1
chr20_-_53949798 1.04 ENSDART00000153435
ppp2r5cb
protein phosphatase 2, regulatory subunit B', gamma b
chr17_+_21514777 1.02 ENSDART00000154633
chst15
carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
chr25_-_35124576 1.01 ENSDART00000128017
zgc:171759
zgc:171759
chr11_+_24348425 0.96 ENSDART00000089747
nfs1
NFS1 cysteine desulfurase
chr7_-_6415991 0.93 ENSDART00000173349
CU457819.3
Histone H3.2
chr16_-_32128345 0.91 ENSDART00000102100
ENSDART00000137699
cnot3a
CCR4-NOT transcription complex, subunit 3a
chr8_+_8947623 0.90 ENSDART00000131215
slc35a2
solute carrier family 35 (UDP-galactose transporter), member 2
chr11_-_45152702 0.87 ENSDART00000168066
afmid
arylformamidase
chr5_+_39099380 0.86 ENSDART00000166657
bmp2k
BMP2 inducible kinase
chr25_-_35109536 0.83 ENSDART00000185229
CU302436.5

chr1_-_20970266 0.82 ENSDART00000088545
klhl2
kelch-like family member 2
chr13_+_15933168 0.82 ENSDART00000131390
fignl1
fidgetin-like 1
chr7_-_6345507 0.80 ENSDART00000173032
CU457819.4
Histone H3.2
chr25_+_35067318 0.79 ENSDART00000186828
CU302436.1

chr14_-_6402769 0.79 ENSDART00000121552
slc44a1b
solute carrier family 44 (choline transporter), member 1b
chr13_-_45942000 0.79 ENSDART00000158534
ENSDART00000171822
ENSDART00000166442
si:ch211-62a1.4
si:ch211-62a1.4
chr7_+_20393386 0.78 ENSDART00000173471
si:dkey-33c9.6
si:dkey-33c9.6
chr19_-_47570672 0.78 ENSDART00000112155
rrm2
ribonucleotide reductase M2 polypeptide
chr21_+_30721733 0.76 ENSDART00000040443
zgc:110224
zgc:110224
chr19_-_48391415 0.72 ENSDART00000170726
ENSDART00000169577
si:ch73-359m17.2
si:ch73-359m17.2
chr10_-_38456382 0.71 ENSDART00000182129
gdpd5a
glycerophosphodiester phosphodiesterase domain containing 5a
chr25_+_35058088 0.68 ENSDART00000156838
zgc:112234
zgc:112234
chr25_+_35062353 0.65 ENSDART00000089844
zgc:113983
zgc:113983
chr18_+_39327010 0.63 ENSDART00000012164
tmod2
tropomodulin 2
chr2_-_57378748 0.61 ENSDART00000149235
tcf3a
transcription factor 3a
chr12_+_47446158 0.58 ENSDART00000152857
fmn2b
formin 2b
chr2_+_37836821 0.56 ENSDART00000143203
parp2
poly (ADP-ribose) polymerase 2
chr10_-_37487612 0.54 ENSDART00000167964
ENSDART00000171326
si:dkey-65j4.2
si:dkey-65j4.2
chr14_+_94603 0.53 ENSDART00000162480
mcm7
minichromosome maintenance complex component 7
chr16_+_35595312 0.53 ENSDART00000170438
si:ch211-1i11.3
si:ch211-1i11.3
chr13_-_22907260 0.51 ENSDART00000143097
rufy2
RUN and FYVE domain containing 2
chr13_+_48359573 0.49 ENSDART00000161959
ENSDART00000165311
msh6
mutS homolog 6 (E. coli)
chr22_-_26274177 0.46 ENSDART00000060978
wdr83
WD repeat domain containing 83
chr24_+_41690545 0.44 ENSDART00000160069
lama1
laminin, alpha 1
chr23_+_20518504 0.41 ENSDART00000114246
adnpb
activity-dependent neuroprotector homeobox b
chr3_-_16227683 0.40 ENSDART00000111707
cacnb1
calcium channel, voltage-dependent, beta 1 subunit
chr24_+_17345521 0.38 ENSDART00000024722
ENSDART00000154250
ezh2
enhancer of zeste 2 polycomb repressive complex 2 subunit
chr3_+_22059066 0.31 ENSDART00000155739
kansl1b
KAT8 regulatory NSL complex subunit 1b
chr3_+_29641181 0.26 ENSDART00000151517
eif3d
eukaryotic translation initiation factor 3, subunit D
chr7_+_34453185 0.24 ENSDART00000173875
ENSDART00000173921
ENSDART00000173995
si:cabz01009626.1
si:cabz01009626.1
chr22_-_21676364 0.21 ENSDART00000183668
tle2b
transducin like enhancer of split 2b
chr20_-_33462961 0.14 ENSDART00000135927
si:dkey-65b13.1
si:dkey-65b13.1
chr18_+_17020967 0.11 ENSDART00000189168
chtf8
CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
chr6_-_425378 0.09 ENSDART00000192190
fam83fb
family with sequence similarity 83, member Fb
chr17_-_50020672 0.07 ENSDART00000188942
filip1a
filamin A interacting protein 1a

Network of associatons between targets according to the STRING database.

First level regulatory network of e2f4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:1903003 positive regulation of protein deubiquitination(GO:1903003)
0.5 1.4 GO:1902767 farnesyl diphosphate biosynthetic process, mevalonate pathway(GO:0010142) isoprenoid biosynthetic process via mevalonate(GO:1902767)
0.2 2.7 GO:0030719 P granule organization(GO:0030719)
0.2 2.4 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.2 1.5 GO:0008207 C21-steroid hormone metabolic process(GO:0008207)
0.2 1.4 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.2 3.1 GO:0051445 regulation of meiotic cell cycle(GO:0051445)
0.2 0.5 GO:0006290 somatic diversification of immune receptors via somatic mutation(GO:0002566) pyrimidine dimer repair(GO:0006290) somatic hypermutation of immunoglobulin genes(GO:0016446)
0.2 0.8 GO:0000012 single strand break repair(GO:0000012)
0.1 0.9 GO:0019441 tryptophan catabolic process to kynurenine(GO:0019441)
0.1 0.9 GO:2000036 regulation of stem cell population maintenance(GO:2000036)
0.1 0.3 GO:0002191 cap-dependent translational initiation(GO:0002191)
0.1 0.7 GO:0035188 hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.1 0.4 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.1 0.6 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.1 0.4 GO:0070734 histone H3-K27 methylation(GO:0070734)
0.1 0.9 GO:0090481 pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.1 0.9 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.0 1.0 GO:0031952 regulation of protein autophosphorylation(GO:0031952)
0.0 1.0 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.6 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.0 1.2 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.0 2.7 GO:0006119 oxidative phosphorylation(GO:0006119)
0.0 0.5 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 1.0 GO:0019319 hexose biosynthetic process(GO:0019319)
0.0 1.7 GO:0007098 centrosome cycle(GO:0007098)
0.0 0.4 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.8 GO:0031122 cytoplasmic microtubule organization(GO:0031122)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.7 GO:0033391 chromatoid body(GO:0033391)
0.2 1.7 GO:0070652 HAUS complex(GO:0070652)
0.2 0.5 GO:0032301 MutSalpha complex(GO:0032301)
0.1 1.9 GO:0015030 Cajal body(GO:0015030)
0.1 3.1 GO:0043186 P granule(GO:0043186)
0.1 0.9 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 1.0 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 1.1 GO:0043596 nuclear replication fork(GO:0043596)
0.0 3.0 GO:0000786 nucleosome(GO:0000786)
0.0 0.4 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.3 GO:0044545 NSL complex(GO:0044545)
0.0 1.2 GO:0005814 centriole(GO:0005814)
0.0 0.9 GO:0031228 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.0 0.3 GO:0016282 eukaryotic 43S preinitiation complex(GO:0016282)
0.0 0.6 GO:0005865 striated muscle thin filament(GO:0005865) myofilament(GO:0036379)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0004421 hydroxymethylglutaryl-CoA synthase activity(GO:0004421)
0.3 2.4 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.3 0.9 GO:0004061 arylformamidase activity(GO:0004061)
0.2 1.9 GO:0017070 U6 snRNA binding(GO:0017070)
0.2 1.4 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.2 0.5 GO:0032143 guanine/thymine mispair binding(GO:0032137) single base insertion or deletion binding(GO:0032138) single thymine insertion binding(GO:0032143) oxidized DNA binding(GO:0032356) oxidized purine DNA binding(GO:0032357) mismatch repair complex binding(GO:0032404) MutLalpha complex binding(GO:0032405)
0.1 2.9 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.9 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.1 0.3 GO:0098808 mRNA cap binding(GO:0098808)
0.1 1.5 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.1 1.7 GO:0051011 microtubule minus-end binding(GO:0051011)
0.1 0.8 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 1.0 GO:0016783 sulfurtransferase activity(GO:0016783)
0.1 0.9 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.1 1.0 GO:0019211 phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542)
0.0 0.6 GO:1990404 protein ADP-ribosylase activity(GO:1990404)
0.0 0.3 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 3.1 GO:0003724 RNA helicase activity(GO:0003724)
0.0 0.6 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.5 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.8 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.1 GO:0043140 ATP-dependent 3'-5' DNA helicase activity(GO:0043140) single-stranded DNA-dependent ATP-dependent 3'-5' DNA helicase activity(GO:1990518)
0.0 3.0 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 0.4 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 1.0 GO:0008146 sulfotransferase activity(GO:0008146)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 2.4 PID E2F PATHWAY E2F transcription factor network
0.0 1.4 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.5 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 1.5 PID CDC42 PATHWAY CDC42 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.4 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 1.0 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 0.9 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.1 1.4 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.0 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.3 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.4 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions