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PRJNA195909:zebrafish embryo and larva development

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Results for e2f8

Z-value: 1.28

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Transcription factors associated with e2f8

Gene Symbol Gene ID Gene Info
e2f8
ENSDARG00000057323 E2F transcription factor 8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
e2f8dr11_v1_chr7_-_16596938_165969380.932.5e-04Click!

Activity profile of e2f8 motif

Sorted Z-values of e2f8 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr9_+_33220342 2.46 ENSDART00000100893
ENSDART00000113451
si:ch211-125e6.13
si:ch211-125e6.13
chr7_-_55648336 2.08 ENSDART00000147792
ENSDART00000135304
ENSDART00000131923
pabpn1l
poly(A) binding protein, nuclear 1-like (cytoplasmic)
chr7_+_24814866 1.87 ENSDART00000173581
si:ch211-226l4.6
si:ch211-226l4.6
chr8_-_44238526 1.50 ENSDART00000061115
ENSDART00000132473
ENSDART00000138019
ENSDART00000133021
piwil1
piwi-like RNA-mediated gene silencing 1
chr13_+_31402067 1.44 ENSDART00000019202
tdrd9
tudor domain containing 9
chr23_-_29357764 1.42 ENSDART00000156512
si:ch211-129o18.4
si:ch211-129o18.4
chr1_-_18811517 1.38 ENSDART00000142026
si:dkey-167i21.2
si:dkey-167i21.2
chr10_+_6884123 1.35 ENSDART00000149095
ENSDART00000148772
ENSDART00000149334
ddx4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
chr13_+_46941930 1.22 ENSDART00000056962
fbxo5
F-box protein 5
chr7_+_41812636 1.21 ENSDART00000174333
orc6
origin recognition complex, subunit 6
chr8_+_41038141 1.20 ENSDART00000075620
gpat2
glycerol-3-phosphate acyltransferase 2, mitochondrial
chr1_-_24558838 1.17 ENSDART00000102522
gatb
glutamyl-tRNA(Gln) amidotransferase, subunit B
chr6_+_21005725 1.13 ENSDART00000041370
cx44.2
connexin 44.2
chr7_+_41812817 1.12 ENSDART00000174165
orc6
origin recognition complex, subunit 6
chr7_-_39360325 1.12 ENSDART00000098033
ENSDART00000173695
ENSDART00000173466
ENSDART00000173734
ambra1a
autophagy/beclin-1 regulator 1a
chr16_-_9453591 1.11 ENSDART00000126154
prpf3
PRP3 pre-mRNA processing factor 3 homolog (yeast)
chr9_+_34380299 1.09 ENSDART00000131705
lamp1
lysosomal-associated membrane protein 1
chr4_-_7869731 1.09 ENSDART00000067339
mcm10
minichromosome maintenance 10 replication initiation factor
chr1_-_34450622 1.07 ENSDART00000083736
lmo7b
LIM domain 7b
chr7_-_6362460 1.02 ENSDART00000129239
hist1h2a4
histone cluster 1 H2A family member 4
chr19_+_40069524 1.02 ENSDART00000151365
ENSDART00000140926
zmym4
zinc finger, MYM-type 4
chr19_+_42660158 1.00 ENSDART00000018328
fbxl2
F-box and leucine-rich repeat protein 2
chr7_+_41812190 1.00 ENSDART00000113732
ENSDART00000174137
orc6
origin recognition complex, subunit 6
chr14_-_28566238 0.98 ENSDART00000172547
insb
preproinsulin b
chr16_+_33953644 0.98 ENSDART00000164447
ENSDART00000159969
arid1aa
AT rich interactive domain 1Aa (SWI-like)
chr11_-_26576754 0.94 ENSDART00000191733
ENSDART00000002846
st3gal8
ST3 beta-galactoside alpha-2,3-sialyltransferase 8
chr7_-_73854476 0.92 ENSDART00000186481
zgc:173552
zgc:173552
chr7_-_73845736 0.92 ENSDART00000193414
zgc:173552
zgc:173552
chr22_-_4439311 0.91 ENSDART00000169317
uhrf1
ubiquitin-like with PHD and ring finger domains 1
chr20_+_13141408 0.87 ENSDART00000034098
dtl
denticleless E3 ubiquitin protein ligase homolog (Drosophila)
chr22_-_38274188 0.86 ENSDART00000139420
ENSDART00000015117
elavl2
ELAV like neuron-specific RNA binding protein 2
chr21_-_11655010 0.86 ENSDART00000144370
ENSDART00000139814
ENSDART00000139289
cast
calpastatin
chr7_+_5956937 0.85 ENSDART00000170763
hist1h2a4
histone cluster 1 H2A family member 4
chr13_-_14929236 0.84 ENSDART00000020576
cdc25b
cell division cycle 25B
chr14_+_49220026 0.84 ENSDART00000063643
ENSDART00000128744
rmnd5b
required for meiotic nuclear division 5 homolog B
chr3_-_35865040 0.83 ENSDART00000102952
suz12a
SUZ12 polycomb repressive complex 2a subunit
chr11_-_11792766 0.83 ENSDART00000011657
cdc6
cell division cycle 6 homolog (S. cerevisiae)
chr23_-_16981899 0.82 ENSDART00000125472
ENSDART00000142297
ENSDART00000143180
dnmt3bb.3
DNA (cytosine-5-)-methyltransferase beta, duplicate b.3
chr5_-_30382925 0.81 ENSDART00000125381
gig2o
grass carp reovirus (GCRV)-induced gene 2o
chr16_+_31942527 0.80 ENSDART00000188334
ENSDART00000188643
ENSDART00000058496
phc1
polyhomeotic homolog 1
chr19_-_2582858 0.79 ENSDART00000113829
cdca7b
cell division cycle associated 7b
chr14_-_32631519 0.79 ENSDART00000167282
ENSDART00000052938
atp11c
ATPase phospholipid transporting 11C
chr9_+_34232503 0.78 ENSDART00000132836
nxpe3
neurexophilin and PC-esterase domain family, member 3
chr21_-_41818359 0.77 ENSDART00000046076
CU929230.1

chr16_+_53278406 0.77 ENSDART00000010792
ptdss1a
phosphatidylserine synthase 1a
chr1_-_45614318 0.76 ENSDART00000149725
atf7ip
activating transcription factor 7 interacting protein
chr6_-_18531760 0.75 ENSDART00000167167
utp6
UTP6, small subunit (SSU) processome component, homolog (yeast)
chr20_+_53368611 0.74 ENSDART00000060432
cdc40
cell division cycle 40 homolog (S. cerevisiae)
chr22_+_26703026 0.73 ENSDART00000158756
crebbpa
CREB binding protein a
chr7_-_804515 0.73 ENSDART00000159359
rela
v-rel avian reticuloendotheliosis viral oncogene homolog A
chr23_-_33738945 0.72 ENSDART00000136386
si:ch211-210c8.7
si:ch211-210c8.7
chr11_+_24804556 0.71 ENSDART00000082761
ENSDART00000186283
adipor1a
adiponectin receptor 1a
chr6_+_38896158 0.70 ENSDART00000029930
ENSDART00000131347
slc48a1b
solute carrier family 48 (heme transporter), member 1b
chr3_-_53092509 0.70 ENSDART00000062081
lpar2a
lysophosphatidic acid receptor 2a
chr24_-_13349802 0.70 ENSDART00000164729
terf1
telomeric repeat binding factor (NIMA-interacting) 1
chr16_-_39195318 0.69 ENSDART00000058546
ebag9
estrogen receptor binding site associated, antigen, 9
chr25_-_35110695 0.69 ENSDART00000099859
hist1h2a10
histone cluster 1 H2A family member 10
chr13_+_48358467 0.69 ENSDART00000171080
ENSDART00000162531
msh6
mutS homolog 6 (E. coli)
chr5_+_22459087 0.69 ENSDART00000134781
BX546499.1

chr4_-_2380173 0.68 ENSDART00000177727
nap1l1
nucleosome assembly protein 1-like 1
chr14_-_31465905 0.66 ENSDART00000173108
gpc3
glypican 3
chr13_+_2894536 0.64 ENSDART00000183678
CABZ01087629.1

chr16_+_25116827 0.64 ENSDART00000163244
si:ch211-261d7.6
si:ch211-261d7.6
chr23_+_39413163 0.64 ENSDART00000184254
src
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr8_+_8196087 0.64 ENSDART00000026965
plxnb3
plexin B3
chr22_+_18349794 0.63 ENSDART00000186580
gatad2ab
GATA zinc finger domain containing 2Ab
chr4_-_73488406 0.62 ENSDART00000115002
si:ch73-266f23.1
si:ch73-266f23.1
chr25_+_35133404 0.60 ENSDART00000188505
hist1h2a2
histone cluster 1 H2A family member 2
chr5_+_13308139 0.60 ENSDART00000182189
ydjc
YdjC chitooligosaccharide deacetylase homolog
chr9_-_2892045 0.60 ENSDART00000137201
cdca7a
cell division cycle associated 7a
chr7_+_71535045 0.59 ENSDART00000047069
tyms
thymidylate synthetase
chr6_-_33916756 0.59 ENSDART00000137447
ENSDART00000138488
nasp
nuclear autoantigenic sperm protein (histone-binding)
chr24_-_30843250 0.59 ENSDART00000162920
ptbp2a
polypyrimidine tract binding protein 2a
chr21_-_11970199 0.59 ENSDART00000114524
nop56
NOP56 ribonucleoprotein homolog
chr7_+_41421998 0.59 ENSDART00000083967
chpf2
chondroitin polymerizing factor 2
chr9_-_48407408 0.59 ENSDART00000058248
zgc:172182
zgc:172182
chr6_-_8466717 0.58 ENSDART00000151577
ENSDART00000151800
ENSDART00000151227
si:dkey-217d24.6
si:dkey-217d24.6
chr3_+_14571813 0.58 ENSDART00000146728
ENSDART00000171731
znf653
zinc finger protein 653
chr20_-_38827623 0.58 ENSDART00000153310
cad
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
chr25_-_26753196 0.57 ENSDART00000155698
usp3
ubiquitin specific peptidase 3
chr2_+_9755422 0.56 ENSDART00000018524
pcyt1aa
phosphate cytidylyltransferase 1, choline, alpha a
chr13_-_45942000 0.56 ENSDART00000158534
ENSDART00000171822
ENSDART00000166442
si:ch211-62a1.4
si:ch211-62a1.4
chr2_-_53500424 0.56 ENSDART00000037557
admp
anti-dorsalizing morphogenic protein
chr15_-_4596623 0.56 ENSDART00000132227
eif4h
eukaryotic translation initiation factor 4h
chr24_-_13349464 0.55 ENSDART00000134482
ENSDART00000139212
terf1
telomeric repeat binding factor (NIMA-interacting) 1
chr11_-_18017918 0.55 ENSDART00000040171
qrich1
glutamine-rich 1
chr13_-_18011168 0.55 ENSDART00000144813
march8
membrane-associated ring finger (C3HC4) 8
chr22_+_8753092 0.55 ENSDART00000140720
si:dkey-182g1.2
si:dkey-182g1.2
chr14_-_33351103 0.55 ENSDART00000010019
upf3b
UPF3B, regulator of nonsense mediated mRNA decay
chr7_+_26545502 0.54 ENSDART00000140528
tnk1
tyrosine kinase, non-receptor, 1
chr20_-_38525467 0.54 ENSDART00000061417
si:ch211-245h14.1
si:ch211-245h14.1
chr25_-_35102781 0.54 ENSDART00000180881
ENSDART00000153747
si:dkey-108k21.24
si:dkey-108k21.24
chr7_-_6355459 0.54 ENSDART00000172898
CU457819.1

chr5_-_20678300 0.53 ENSDART00000088639
wscd2
WSC domain containing 2
chr7_-_6345507 0.53 ENSDART00000173032
CU457819.4
Histone H3.2
chr3_+_52545400 0.53 ENSDART00000184183
slc27a1a
solute carrier family 27 (fatty acid transporter), member 1a
chr22_+_8753365 0.52 ENSDART00000106086
si:dkey-182g1.2
si:dkey-182g1.2
chr11_-_18107447 0.52 ENSDART00000187376
qrich1
glutamine-rich 1
chr17_+_11372531 0.51 ENSDART00000130975
ENSDART00000149366
timm9
translocase of inner mitochondrial membrane 9 homolog
chr11_-_18017287 0.51 ENSDART00000155443
qrich1
glutamine-rich 1
chr7_+_26545911 0.51 ENSDART00000135313
tnk1
tyrosine kinase, non-receptor, 1
chr23_+_10805188 0.51 ENSDART00000035693
ppp4r2a
protein phosphatase 4, regulatory subunit 2a
chr25_-_35140746 0.49 ENSDART00000129969
si:ch211-113a14.19
si:ch211-113a14.19
chr6_+_21062416 0.49 ENSDART00000141643
si:dkey-91f15.1
si:dkey-91f15.1
chr11_+_45092866 0.48 ENSDART00000163408
si:dkey-93h22.8
si:dkey-93h22.8
chr13_+_48359573 0.47 ENSDART00000161959
ENSDART00000165311
msh6
mutS homolog 6 (E. coli)
chr25_-_35145920 0.46 ENSDART00000157137
si:dkey-261m9.19
si:dkey-261m9.19
chr12_+_17933775 0.46 ENSDART00000186047
ENSDART00000160586
trrap
transformation/transcription domain-associated protein
chr9_-_2892250 0.46 ENSDART00000140695
cdca7a
cell division cycle associated 7a
chr2_+_37424261 0.45 ENSDART00000132427
phc3
polyhomeotic homolog 3 (Drosophila)
chr3_-_26806032 0.44 ENSDART00000143710
pigq
phosphatidylinositol glycan anchor biosynthesis, class Q
chr9_-_49964810 0.44 ENSDART00000167098
scn1a
sodium channel, voltage-gated, type I, alpha
chr1_+_59142783 0.43 ENSDART00000152669
gpr108
G protein-coupled receptor 108
chr5_-_64454459 0.43 ENSDART00000172321
ENSDART00000168030
brd3b
bromodomain containing 3b
chr6_+_50451337 0.43 ENSDART00000155051
mych
myelocytomatosis oncogene homolog
chr2_-_6104035 0.42 ENSDART00000053867
zte38
zebrafish testis-expressed 38
chr16_-_12723738 0.42 ENSDART00000080414
sbk3
SH3 domain binding kinase family, member 3
chr11_+_3005536 0.42 ENSDART00000174539
cpne5b
copine Vb
chr16_-_43011470 0.42 ENSDART00000131898
ENSDART00000142003
ENSDART00000017966
nudt17
nudix (nucleoside diphosphate linked moiety X)-type motif 17
chr13_-_18069421 0.42 ENSDART00000146772
ENSDART00000134477
zfand4
zinc finger, AN1-type domain 4
chr7_-_6415991 0.41 ENSDART00000173349
CU457819.3
Histone H3.2
chr25_-_35109536 0.41 ENSDART00000185229
CU302436.5

chr12_+_21299338 0.41 ENSDART00000074540
ENSDART00000133188
ca10a
carbonic anhydrase Xa
chr3_-_14571514 0.39 ENSDART00000137197
swsap1
SWIM-type zinc finger 7 associated protein 1
chr10_-_37487612 0.39 ENSDART00000167964
ENSDART00000171326
si:dkey-65j4.2
si:dkey-65j4.2
chr11_+_3006124 0.38 ENSDART00000126071
cpne5b
copine Vb
chr24_-_26945390 0.36 ENSDART00000123354
msl2b
male-specific lethal 2 homolog b (Drosophila)
chr3_+_43086548 0.36 ENSDART00000163579
si:dkey-43p13.5
si:dkey-43p13.5
chr22_-_22301672 0.36 ENSDART00000111711
chaf1a
chromatin assembly factor 1, subunit A (p150)
chr6_+_18531932 0.35 ENSDART00000165271
suz12b
SUZ12 polycomb repressive complex 2b subunit
chr19_-_32042105 0.35 ENSDART00000088358
znf704
zinc finger protein 704
chr3_+_52545014 0.35 ENSDART00000018908
slc27a1a
solute carrier family 27 (fatty acid transporter), member 1a
chr5_-_28016805 0.35 ENSDART00000078642
vps37b
vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr20_+_18703454 0.35 ENSDART00000152342
eif5
eukaryotic translation initiation factor 5
chr13_+_26703922 0.34 ENSDART00000020946
fancl
Fanconi anemia, complementation group L
chr16_-_22775480 0.34 ENSDART00000141778
ENSDART00000145585
ENSDART00000125963
ENSDART00000127570
pbxip1b
pre-B-cell leukemia homeobox interacting protein 1b
chr10_+_573667 0.34 ENSDART00000110384
smad4a
SMAD family member 4a
chr18_+_45708744 0.34 ENSDART00000077341
depdc7
DEP domain containing 7
chr15_-_37104165 0.33 ENSDART00000165867
zmp:0000001114
zmp:0000001114
chr4_+_13953537 0.32 ENSDART00000133596
pphln1
periphilin 1
chr13_-_1423008 0.31 ENSDART00000110828
znf451
zinc finger protein 451
chr6_-_28345002 0.31 ENSDART00000158955
si:busm1-105l16.2
si:busm1-105l16.2
chr1_-_46505310 0.30 ENSDART00000178072
si:busm1-105l16.2
si:busm1-105l16.2
chr19_-_30359059 0.29 ENSDART00000103471
khdrbs1b
KH domain containing, RNA binding, signal transduction associated 1b
chr20_+_41859277 0.29 ENSDART00000061141
cep85l
centrosomal protein 85, like
chr7_+_23495986 0.28 ENSDART00000190739
ENSDART00000115299
ENSDART00000101423
ENSDART00000142401
zgc:109889
zgc:109889
chr5_-_37959874 0.28 ENSDART00000031719
mpzl2b
myelin protein zero-like 2b
chr2_-_57378748 0.28 ENSDART00000149235
tcf3a
transcription factor 3a
chr20_+_27093042 0.28 ENSDART00000024595
ubr7
ubiquitin protein ligase E3 component n-recognin 7
chr5_+_66310495 0.27 ENSDART00000114532
malt1
MALT paracaspase 1
chr15_+_23657051 0.27 ENSDART00000078336
klc3
kinesin light chain 3
chr25_+_7532627 0.26 ENSDART00000187660
ptdss2
phosphatidylserine synthase 2
chr20_+_23408970 0.25 ENSDART00000144261
fryl
furry homolog, like
chr1_-_45614481 0.25 ENSDART00000148413
atf7ip
activating transcription factor 7 interacting protein
chr22_-_26274177 0.24 ENSDART00000060978
wdr83
WD repeat domain containing 83
chr21_-_31252131 0.24 ENSDART00000121946
crcp
calcitonin gene-related peptide-receptor component protein
chr16_-_15988320 0.24 ENSDART00000160883
CABZ01060453.1

chr6_-_40899618 0.24 ENSDART00000153949
ENSDART00000021969
zgc:172271
zgc:172271
chr24_-_2829049 0.24 ENSDART00000164913
PPP1R3G
si:ch211-152c8.5
chr19_-_14155781 0.24 ENSDART00000169232
nr0b2b
nuclear receptor subfamily 0, group B, member 2b
chr18_+_27571448 0.23 ENSDART00000147886
cd82b
CD82 molecule b
chr17_-_36529016 0.23 ENSDART00000025019
colec11
collectin sub-family member 11
chr21_+_37090795 0.23 ENSDART00000085786
znf346
zinc finger protein 346
chr7_+_28724919 0.22 ENSDART00000011324
ccdc102a
coiled-coil domain containing 102A
chr3_-_49514874 0.21 ENSDART00000167179
asf1ba
anti-silencing function 1Ba histone chaperone
chr13_+_8255106 0.21 ENSDART00000080465
hells
helicase, lymphoid specific
chr17_-_36529449 0.19 ENSDART00000187252
colec11
collectin sub-family member 11
chr21_-_2360906 0.19 ENSDART00000171645
si:ch73-299h12.9
si:ch73-299h12.9
chr7_+_62320134 0.18 ENSDART00000012089
stim2b
stromal interaction molecule 2b
chr7_+_28960518 0.17 ENSDART00000182903
ENSDART00000188250
ENSDART00000191830
dok4
docking protein 4
chr23_-_10137322 0.16 ENSDART00000142442
plxnb1a
plexin b1a
chr11_-_38554394 0.16 ENSDART00000102858
nucks1a
nuclear casein kinase and cyclin-dependent kinase substrate 1a
chr18_-_35842554 0.15 ENSDART00000088488
opa3
optic atrophy 3
chr11_-_6206520 0.15 ENSDART00000150199
ENSDART00000148246
ENSDART00000019440
pole4
polymerase (DNA-directed), epsilon 4, accessory subunit
chr17_-_47220934 0.15 ENSDART00000158740
alk
ALK receptor tyrosine kinase
chr22_+_25590391 0.15 ENSDART00000178133
aars2
alanyl-tRNA synthetase 2, mitochondrial (putative)
chr8_+_29856013 0.15 ENSDART00000061981
ENSDART00000149610
hsd17b3
hydroxysteroid (17-beta) dehydrogenase 3
chr25_+_31912153 0.14 ENSDART00000153968
apba2a
amyloid beta (A4) precursor protein-binding, family A, member 2a
chr1_+_6243906 0.14 ENSDART00000127329
gtf3c3
general transcription factor IIIC, polypeptide 3
chr1_+_6646529 0.13 ENSDART00000144641
ENSDART00000103701
ENSDART00000138919
ube2f
ubiquitin-conjugating enzyme E2F (putative)
chr1_+_18811679 0.13 ENSDART00000078610
slc25a51a
solute carrier family 25, member 51a
chr1_+_38858399 0.12 ENSDART00000165454
CU915762.1

chr2_+_17055069 0.11 ENSDART00000115078
thpo
thrombopoietin
chr7_+_34453185 0.10 ENSDART00000173875
ENSDART00000173921
ENSDART00000173995
si:cabz01009626.1
si:cabz01009626.1
chr7_+_29509255 0.09 ENSDART00000076172
si:dkey-182o15.5
si:dkey-182o15.5
chr1_-_38170997 0.09 ENSDART00000142811
hmgb2a
high mobility group box 2a
chr10_+_26646104 0.09 ENSDART00000187685
adgrg4b
adhesion G protein-coupled receptor G4b
chr11_-_4302251 0.09 ENSDART00000182554
CT033790.1

chr18_+_33788340 0.08 ENSDART00000136950
si:dkey-145c18.2
si:dkey-145c18.2
chr3_+_8826905 0.08 ENSDART00000167474
ENSDART00000168088
si:dkeyp-30d6.2
si:dkeyp-30d6.2
chr1_-_58505626 0.07 ENSDART00000171304
si:ch73-236c18.8
si:ch73-236c18.8
chr13_+_30421472 0.07 ENSDART00000143569
zmiz1a
zinc finger, MIZ-type containing 1a
chr18_+_33762090 0.07 ENSDART00000147605
si:dkey-145c18.4
si:dkey-145c18.4
chr4_+_74943111 0.07 ENSDART00000004739
nup50
nucleoporin 50
chr7_+_1550966 0.06 ENSDART00000177863
ENSDART00000126840
supt16h
SPT16 homolog, facilitates chromatin remodeling subunit
chr8_-_37461835 0.06 ENSDART00000013446
eif2d
eukaryotic translation initiation factor 2D
chr23_-_44848961 0.05 ENSDART00000136839
wu:fb72h05
wu:fb72h05
chr25_-_35524166 0.04 ENSDART00000156782
slc5a12
solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12
chr8_-_2543327 0.03 ENSDART00000134115
si:ch211-51h9.6
si:ch211-51h9.6
chr2_-_25120197 0.03 ENSDART00000132549
pccb
propionyl CoA carboxylase, beta polypeptide

Network of associatons between targets according to the STRING database.

First level regulatory network of e2f8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0016446 somatic diversification of immune receptors via somatic mutation(GO:0002566) pyrimidine dimer repair(GO:0006290) somatic hypermutation of immunoglobulin genes(GO:0016446)
0.3 2.9 GO:0010529 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.3 1.2 GO:0051444 negative regulation of ligase activity(GO:0051352) negative regulation of ubiquitin-protein transferase activity(GO:0051444) negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.3 1.2 GO:1990511 piRNA biosynthetic process(GO:1990511)
0.2 0.6 GO:0050847 progesterone receptor signaling pathway(GO:0050847)
0.2 0.8 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.2 0.6 GO:0009162 deoxyribonucleoside monophosphate metabolic process(GO:0009162)
0.2 0.6 GO:0021563 glossopharyngeal nerve development(GO:0021563)
0.2 1.9 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.2 0.6 GO:0060063 Spemann organizer formation at the embryonic shield(GO:0060063)
0.2 0.8 GO:0009794 regulation of mitotic cell cycle, embryonic(GO:0009794) mitotic cell cycle, embryonic(GO:0045448)
0.1 0.7 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.1 0.7 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.1 0.4 GO:0019364 pyridine nucleotide catabolic process(GO:0019364) NAD catabolic process(GO:0019677) pyridine-containing compound catabolic process(GO:0072526)
0.1 0.5 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.1 0.9 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.1 0.9 GO:0097341 inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341)
0.1 4.1 GO:0006270 DNA replication initiation(GO:0006270)
0.1 1.1 GO:0044030 regulation of DNA methylation(GO:0044030)
0.1 1.4 GO:0051445 regulation of meiotic cell cycle(GO:0051445)
0.1 0.7 GO:0060976 coronary vasculature development(GO:0060976)
0.1 0.6 GO:0097010 eukaryotic translation initiation factor 4F complex assembly(GO:0097010)
0.1 1.0 GO:0006346 methylation-dependent chromatin silencing(GO:0006346) positive regulation of chromatin silencing(GO:0031937) regulation of methylation-dependent chromatin silencing(GO:0090308) positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.1 0.7 GO:1901678 heme transport(GO:0015886) iron coordination entity transport(GO:1901678)
0.1 0.3 GO:0097355 protein localization to heterochromatin(GO:0097355)
0.1 0.5 GO:0051673 membrane disruption in other organism(GO:0051673)
0.1 1.3 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.0 0.1 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.0 1.2 GO:0043039 amino acid activation(GO:0043038) tRNA aminoacylation(GO:0043039)
0.0 0.2 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0 0.3 GO:1905097 regulation of guanyl-nucleotide exchange factor activity(GO:1905097) regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.0 0.8 GO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance(GO:1902285) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)
0.0 0.4 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.0 0.6 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 0.4 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 1.0 GO:0051092 positive regulation of NF-kappaB transcription factor activity(GO:0051092)
0.0 0.4 GO:0019730 antimicrobial humoral response(GO:0019730)
0.0 1.1 GO:0048538 thymus development(GO:0048538)
0.0 0.2 GO:1901341 activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 0.3 GO:2000142 regulation of transcription initiation from RNA polymerase II promoter(GO:0060260) regulation of DNA-templated transcription, initiation(GO:2000142)
0.0 0.7 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 1.3 GO:0006342 chromatin silencing(GO:0006342)
0.0 0.7 GO:0001878 response to yeast(GO:0001878)
0.0 0.1 GO:0034724 DNA replication-independent nucleosome organization(GO:0034724)
0.0 0.5 GO:0035675 neuromast hair cell development(GO:0035675)
0.0 0.3 GO:2000601 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 0.5 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 1.0 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
0.0 0.5 GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity(GO:0051091)
0.0 1.2 GO:0006119 oxidative phosphorylation(GO:0006119)
0.0 0.5 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 0.4 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 0.8 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 1.0 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.8 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.3 GO:0048264 determination of ventral identity(GO:0048264)
0.0 0.1 GO:0046070 dGTP catabolic process(GO:0006203) purine nucleoside triphosphate catabolic process(GO:0009146) purine deoxyribonucleoside triphosphate catabolic process(GO:0009217) dGTP metabolic process(GO:0046070)
0.0 1.0 GO:0006006 glucose metabolic process(GO:0006006)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0032301 MutSalpha complex(GO:0032301)
0.3 0.9 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.3 3.3 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.2 1.1 GO:0031298 replication fork protection complex(GO:0031298)
0.2 0.5 GO:0030289 protein phosphatase 4 complex(GO:0030289)
0.2 0.8 GO:0034657 GID complex(GO:0034657)
0.1 4.3 GO:0043186 P granule(GO:0043186)
0.1 1.0 GO:0035060 brahma complex(GO:0035060)
0.1 0.7 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.1 0.6 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.1 0.4 GO:0033186 CAF-1 complex(GO:0033186)
0.1 0.4 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 0.9 GO:0000792 heterochromatin(GO:0000792)
0.1 1.3 GO:0000782 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783) nuclear chromosome, telomeric region(GO:0000784)
0.0 1.1 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.0 0.4 GO:0072487 MSL complex(GO:0072487)
0.0 4.0 GO:0000786 nucleosome(GO:0000786)
0.0 0.8 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.1 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.5 GO:0005922 connexon complex(GO:0005922)
0.0 0.5 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.8 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.6 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.3 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.5 GO:0000124 SAGA complex(GO:0000124)
0.0 0.7 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.1 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.7 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 0.3 GO:0031209 SCAR complex(GO:0031209)
0.0 0.3 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.4 GO:1990391 DNA repair complex(GO:1990391)
0.0 1.7 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 1.0 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.2 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0071532 ankyrin repeat binding(GO:0071532)
0.4 1.2 GO:0032356 guanine/thymine mispair binding(GO:0032137) single base insertion or deletion binding(GO:0032138) single thymine insertion binding(GO:0032143) oxidized DNA binding(GO:0032356) oxidized purine DNA binding(GO:0032357) mismatch repair complex binding(GO:0032404) MutLalpha complex binding(GO:0032405)
0.2 0.6 GO:0016743 carboxyl- or carbamoyltransferase activity(GO:0016743)
0.2 1.5 GO:0034584 piRNA binding(GO:0034584)
0.2 1.2 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.1 0.4 GO:0042806 fucose binding(GO:0042806)
0.1 0.9 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1 0.9 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 0.9 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.1 0.6 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.1 1.2 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.1 0.7 GO:0015232 heme transporter activity(GO:0015232)
0.1 0.4 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.1 0.6 GO:0033592 RNA strand annealing activity(GO:0033592) RNA strand-exchange activity(GO:0034057)
0.1 0.4 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.1 0.3 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.1 1.3 GO:0030515 snoRNA binding(GO:0030515)
0.1 1.9 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.6 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.1 0.8 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.7 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.1 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.0 1.0 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.5 GO:0005243 gap junction channel activity(GO:0005243)
0.0 2.8 GO:0003724 RNA helicase activity(GO:0003724)
0.0 0.3 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.8 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.8 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.3 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 1.6 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 1.6 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 4.2 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 0.5 GO:0042287 MHC protein binding(GO:0042287)
0.0 0.3 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.8 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.6 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.6 GO:0019213 deacetylase activity(GO:0019213)
0.0 0.4 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.3 GO:0008143 poly(A) binding(GO:0008143)
0.0 0.1 GO:0016793 dGTPase activity(GO:0008832) triphosphoric monoester hydrolase activity(GO:0016793)
0.0 2.5 GO:0042393 histone binding(GO:0042393)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 0.6 ST STAT3 PATHWAY STAT3 Pathway
0.0 0.7 PID IL23 PATHWAY IL23-mediated signaling events
0.0 1.2 PID PLK1 PATHWAY PLK1 signaling events
0.0 1.0 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.3 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.8 PID ATR PATHWAY ATR signaling pathway
0.0 0.3 PID BARD1 PATHWAY BARD1 signaling events
0.0 1.0 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.3 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.2 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.1 1.8 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 0.7 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.1 0.6 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 0.8 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 1.2 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.7 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.6 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 1.3 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.4 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.6 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.6 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.4 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.4 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.3 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 0.1 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 0.6 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.3 REACTOME KINESINS Genes involved in Kinesins
0.0 0.5 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.6 REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S