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PRJNA195909:zebrafish embryo and larva development
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Results for e4f1+si:dkeyp-79b7.12
Z-value: 1.00
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Transcription factors associated with e4f1+si:dkeyp-79b7.12
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| e4f1 | dr11_v1_chr3_-_18737126_18737126 | 0.78 | 1.3e-02 | Click! |
| si:dkeyp-79b7.12 | dr11_v1_chr22_+_2207502_2207502 | 0.59 | 9.6e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_44801968 Show fit | 2.27 |
ENSDART00000161846
|
microtubule-associated protein 1 light chain 3 gamma |
|
| chr17_+_25187226 Show fit | 1.58 |
ENSDART00000148431
|
CLN8, transmembrane ER and ERGIC protein |
|
| chr20_-_44576949 Show fit | 1.43 |
ENSDART00000148639
|
UBX domain protein 2A |
|
| chr15_+_5116179 Show fit | 1.29 |
ENSDART00000101937
|
phosphoglucomutase 2-like 1 |
|
| chr19_+_42660158 Show fit | 1.28 |
ENSDART00000018328
|
F-box and leucine-rich repeat protein 2 |
|
| chr23_-_32157865 Show fit | 1.24 |
ENSDART00000000876
|
nuclear receptor subfamily 4, group A, member 1 |
|
| chr8_-_410199 Show fit | 1.21 |
ENSDART00000091177
ENSDART00000122979 ENSDART00000151331 ENSDART00000151155 |
tripartite motif containing 36 |
|
| chr8_-_410728 Show fit | 1.14 |
ENSDART00000151255
|
tripartite motif containing 36 |
|
| chr5_-_29531948 Show fit | 1.12 |
ENSDART00000098360
|
arrestin domain containing 1a |
|
| chr5_+_44846434 Show fit | 1.10 |
ENSDART00000145299
ENSDART00000136521 |
KN motif and ankyrin repeat domains 1a |
Network of associatons between targets according to the STRING database.
First level regulatory network of e4f1+si:dkeyp-79b7.12
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.4 | GO:0043562 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
| 0.0 | 1.9 | GO:0032272 | negative regulation of actin filament polymerization(GO:0030837) negative regulation of protein polymerization(GO:0032272) |
| 0.1 | 1.6 | GO:0043928 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928) |
| 0.0 | 1.6 | GO:0055088 | lipid homeostasis(GO:0055088) |
| 0.2 | 1.5 | GO:0071376 | response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376) |
| 0.3 | 1.4 | GO:1990918 | double-strand break repair involved in meiotic recombination(GO:1990918) |
| 0.1 | 1.4 | GO:0031468 | nuclear envelope reassembly(GO:0031468) |
| 0.4 | 1.3 | GO:0045040 | outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040) |
| 0.0 | 1.3 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.0 | 1.0 | GO:0042752 | regulation of circadian rhythm(GO:0042752) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.4 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.0 | 2.2 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.1 | 1.6 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
| 0.2 | 1.3 | GO:0001401 | mitochondrial sorting and assembly machinery complex(GO:0001401) |
| 0.0 | 1.2 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 1.0 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.1 | 0.8 | GO:0000172 | ribonuclease MRP complex(GO:0000172) |
| 0.0 | 0.8 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.1 | 0.6 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 0.0 | 0.6 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.4 | GO:0031625 | ubiquitin protein ligase binding(GO:0031625) |
| 0.2 | 1.6 | GO:0097001 | sphingolipid binding(GO:0046625) ceramide binding(GO:0097001) |
| 0.1 | 1.6 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.1 | 1.5 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.0 | 1.5 | GO:0043130 | ubiquitin binding(GO:0043130) |
| 0.0 | 1.4 | GO:0003678 | DNA helicase activity(GO:0003678) |
| 0.1 | 1.3 | GO:0016868 | intramolecular transferase activity, phosphotransferases(GO:0016868) |
| 0.2 | 1.1 | GO:1990756 | protein binding, bridging involved in substrate recognition for ubiquitination(GO:1990756) |
| 0.0 | 1.0 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.2 | 0.9 | GO:0008432 | JUN kinase binding(GO:0008432) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 1.2 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 0.8 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.0 | 0.6 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.4 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 1.6 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 1.2 | REACTOME PIP3 ACTIVATES AKT SIGNALING | Genes involved in PIP3 activates AKT signaling |
| 0.0 | 0.7 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.0 | 0.7 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.0 | 0.5 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.0 | 0.5 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.0 | 0.4 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.0 | 0.1 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |