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PRJNA195909:zebrafish embryo and larva development

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Results for ebf3a-2+ebf3b

Z-value: 1.19

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Transcription factors associated with ebf3a-2+ebf3b

Gene Symbol Gene ID Gene Info
ENSDARG00000091287 EBF transcription factor 3b
ENSDARG00000100244 EBF transcription factor 3a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ebf3adr11_v1_chr12_+_42436328_424363280.924.0e-04Click!
ebf3bdr11_v1_chr17_-_20229812_202298120.265.0e-01Click!

Activity profile of ebf3a-2+ebf3b motif

Sorted Z-values of ebf3a-2+ebf3b motif

Promoter Log-likelihood Transcript Gene Gene Info
chr23_-_21471022 5.51 ENSDART00000104206
hairy-related 4, tandem duplicate 2
chr23_+_21455152 2.82 ENSDART00000158511
ENSDART00000161321
ENSDART00000160731
ENSDART00000137573
hairy-related 4, tandem duplicate 2
chr25_+_31323978 2.81 ENSDART00000067030
lymphocyte-specific protein 1
chr9_-_7673856 2.40 ENSDART00000102715
tubulin, alpha 8 like 3
chr11_+_41981959 2.33 ENSDART00000055707
hairy and enhancer of split-related 15, tandem duplicate 1
chr7_-_52558495 2.27 ENSDART00000138263
ENSDART00000009938
ENSDART00000174292
ENSDART00000174218
ENSDART00000174335
transcription factor 12
chr21_+_5129513 2.13 ENSDART00000102572
thrombospondin 4b
chr22_+_11775269 2.08 ENSDART00000140272
keratin 96
chr22_+_11756040 1.92 ENSDART00000105808
keratin 97
chr22_-_23253481 1.89 ENSDART00000054807
LIM homeobox 9
chr13_-_31452516 1.82 ENSDART00000193268
reticulon 1a
chr13_-_16226312 1.81 ENSDART00000163952
zgc:110045
chr20_+_34933183 1.72 ENSDART00000062738
synaptosomal-associated protein, 25a
chr23_+_21459263 1.66 ENSDART00000104209
hairy-related 4, tandem duplicate 3
chr15_+_1372343 1.60 ENSDART00000152285
schwannomin interacting protein 1
chr24_-_23942722 1.56 ENSDART00000080810
aristaless related homeobox a
chr23_+_35672542 1.55 ENSDART00000046268
premelanosome protein b
chr11_-_27501027 1.50 ENSDART00000065889
wingless-type MMTV integration site family, member 7Aa
chr8_-_1051438 1.47 ENSDART00000067093
ENSDART00000170737
SET and MYND domain containing 1b
chr15_-_24869826 1.44 ENSDART00000127047
tumor suppressor candidate 5a
chr19_+_19756425 1.41 ENSDART00000167606
homeobox A3a
chr17_-_21441464 1.39 ENSDART00000031490
ventral anterior homeobox 1
chr19_+_19786117 1.36 ENSDART00000167757
ENSDART00000163546
homeobox A1a
chr25_+_21324588 1.36 ENSDART00000151842
leucine rich repeat neuronal 3a
chr6_+_54711306 1.36 ENSDART00000074605
plakophilin 1b
chr8_+_31821396 1.32 ENSDART00000077053
phosphatidylinositol-specific phospholipase C, X domain containing 3
chr13_+_502230 1.32 ENSDART00000013007
delta(4)-desaturase, sphingolipid 1
chr1_-_35924495 1.27 ENSDART00000184424
SMAD family member 1
chr6_-_49673476 1.22 ENSDART00000112226
adenomatosis polyposis coli down-regulated 1-like
chr13_-_31622195 1.20 ENSDART00000057432
SIX homeobox 1a
chr3_-_25813426 1.16 ENSDART00000039482
netrin 1b
chr19_+_10979983 1.12 ENSDART00000142975
si:ch1073-70f20.1
chr1_-_21409877 1.11 ENSDART00000102782
glutamate receptor, ionotropic, AMPA 2a
chr17_+_38566717 1.10 ENSDART00000145147
spectrin, beta, erythrocytic
chr24_+_4977862 1.07 ENSDART00000114537
zic family member 4
chr19_-_8880688 1.07 ENSDART00000039629
cugbp, Elav-like family member 3a
chr23_-_5683147 1.06 ENSDART00000102766
ENSDART00000067351
troponin T type 2a (cardiac)
chr22_-_23253252 1.06 ENSDART00000175556
LIM homeobox 9
chr21_-_37194839 1.04 ENSDART00000175126
fibroblast growth factor receptor 4
chr20_-_53321499 1.02 ENSDART00000179894
ENSDART00000127427
ENSDART00000084952
WAS protein family, member 1
chr5_+_23634665 1.02 ENSDART00000125161
connexin 39.9
chr20_+_6590220 1.02 ENSDART00000136567
tensin 3, tandem duplicate 2
chr24_+_4978055 1.01 ENSDART00000045813
zic family member 4
chr17_+_17955063 1.00 ENSDART00000104999
coiled-coil domain containing 85C, a
chr21_+_21374277 0.96 ENSDART00000079431
reticulon 2b
chr6_+_45932276 0.93 ENSDART00000103491
retinol binding protein 7b, cellular
chr16_-_35952789 0.92 ENSDART00000180118
eva-1 homolog Ba (C. elegans)
chr21_-_37194365 0.90 ENSDART00000100286
fibroblast growth factor receptor 4
chr10_+_158590 0.89 ENSDART00000081982
potassium voltage-gated channel subfamily J member 15
chr9_-_31278048 0.89 ENSDART00000022204
zic family member 5 (odd-paired homolog, Drosophila)
chr15_+_59417 0.88 ENSDART00000187260
AXL receptor tyrosine kinase
chr9_-_98982 0.86 ENSDART00000147882
LIM and senescent cell antigen-like domains 2
chr3_-_28665291 0.82 ENSDART00000151670
F-box and leucine-rich repeat protein 16
chr23_+_19814371 0.78 ENSDART00000182897
emerin (Emery-Dreifuss muscular dystrophy)
chr24_+_3972260 0.78 ENSDART00000131753
phosphofructokinase, platelet a
chr7_-_18554603 0.78 ENSDART00000108938
Myb/SANT-like DNA-binding domain containing 1
chr23_+_20931030 0.77 ENSDART00000167014
paired box 7b
chr21_-_37194669 0.77 ENSDART00000192748
fibroblast growth factor receptor 4
chr16_-_32013913 0.76 ENSDART00000030282
ENSDART00000138701
glutathione S-transferase kappa 1
chr10_-_5016997 0.75 ENSDART00000101414
heterogeneous nuclear ribonucleoprotein D
chr12_+_31673588 0.73 ENSDART00000152971
dynamin binding protein
chr10_-_27199135 0.70 ENSDART00000189511
ENSDART00000180314
autism susceptibility candidate 2a
chr4_+_8638622 0.69 ENSDART00000186829
wingless-type MMTV integration site family, member 5b
chr16_-_36834505 0.68 ENSDART00000141275
ENSDART00000139588
ENSDART00000041993
purine nucleoside phosphorylase 4b
chr6_+_7250824 0.68 ENSDART00000177226
DAZ interacting zinc finger protein 1
chr11_-_31039533 0.66 ENSDART00000127355
immediate early response 2b
chr7_+_54617060 0.65 ENSDART00000158898
fibroblast growth factor 4
chr25_-_24074500 0.64 ENSDART00000040410
tyrosine hydroxylase
chr13_+_17702853 0.64 ENSDART00000145438
si:dkey-27m7.4
chr15_+_37559570 0.62 ENSDART00000085522
heat shock protein, alpha-crystallin-related, b6
chr17_+_53425730 0.61 ENSDART00000127617
fatty acid binding protein 10b, liver basic
chr6_+_58406014 0.61 ENSDART00000044241
potassium voltage-gated channel, KQT-like subfamily, member 2b
chr14_-_2196267 0.60 ENSDART00000161674
ENSDART00000125674
protocadherin 2 alpha b 8
protocadherin 2 alpha b 9
chr16_+_20198064 0.59 ENSDART00000006037
collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
chr3_-_3496738 0.58 ENSDART00000186849

chr17_-_22324727 0.54 ENSDART00000160341

chr5_-_62801724 0.54 ENSDART00000144469
adenosine A2b receptor
chr20_+_2039518 0.53 ENSDART00000043157

chr18_+_6054816 0.53 ENSDART00000113668
si:ch73-386h18.1
chr3_+_50310684 0.52 ENSDART00000112152
growth arrest-specific 7a
chr13_+_17702522 0.52 ENSDART00000057913
si:dkey-27m7.4
chr4_-_9008846 0.51 ENSDART00000164632
ENSDART00000091876
signal peptide, CUB domain, EGF-like 1
chr7_+_66822229 0.50 ENSDART00000112109
lymphatic vessel endothelial hyaluronic receptor 1a
chr19_+_1370504 0.47 ENSDART00000158946
diacylglycerol O-acyltransferase 1a
chr2_-_32551178 0.47 ENSDART00000145603
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3a
chr23_+_16948049 0.45 ENSDART00000139449
si:dkey-147f3.4
chr25_-_20523927 0.45 ENSDART00000114448
si:ch211-269c21.2
chr24_-_13364311 0.44 ENSDART00000183808
si:dkey-192j17.1
chr7_-_33949246 0.43 ENSDART00000173513
protein inhibitor of activated STAT, 1a
chr2_-_32457919 0.43 ENSDART00000132792
ENSDART00000041319
solute carrier family 4 (anion exchanger), member 2a
chr8_-_15182232 0.42 ENSDART00000138855
BCAR3, NSP family adaptor protein
chr5_-_62801879 0.41 ENSDART00000191749
adenosine A2b receptor
chr8_+_30671060 0.39 ENSDART00000193749
adenosine A2a receptor a
chr5_+_38900249 0.35 ENSDART00000097856
Fraser extracellular matrix complex subunit 1
chr6_+_55277419 0.35 ENSDART00000083670

chr13_+_3954715 0.35 ENSDART00000182477
ENSDART00000192142
ENSDART00000190962
leucine rich repeat containing 73
chr13_-_40316367 0.34 ENSDART00000009343
pyridine nucleotide-disulphide oxidoreductase domain 2
chr8_+_26293673 0.34 ENSDART00000144977
monoglyceride lipase
chr6_-_8399486 0.34 ENSDART00000189496
prostaglandin E receptor 1a (subtype EP1)
chr6_+_2951645 0.34 ENSDART00000183181
ENSDART00000181271
protein tyrosine phosphatase, receptor type, f, a
chr24_-_29777413 0.32 ENSDART00000087724
wu:fj05g07
chr8_-_3716734 0.32 ENSDART00000172966
BICD family like cargo adaptor 1
chr18_+_40471826 0.32 ENSDART00000098806
UDP glucuronosyltransferase 5 family, polypeptide C3
chr15_+_16521785 0.31 ENSDART00000062191
polypeptide N-acetylgalactosaminyltransferase 17
chr22_-_23545307 0.29 ENSDART00000166915
crumbs family member 1, photoreceptor morphogenesis associated
chr7_-_52334840 0.29 ENSDART00000174173

chr18_-_21640389 0.28 ENSDART00000100857
solute carrier family 38, member 8a
chr24_-_27400017 0.27 ENSDART00000145829
chemokine (C-C motif) ligand 34b, duplicate 1
chr13_+_29193649 0.26 ENSDART00000045951
unc-5 netrin receptor B
chr6_-_40697585 0.25 ENSDART00000113196
si:ch211-157b11.14
chr13_-_17723417 0.25 ENSDART00000183834
voltage-dependent anion channel 2
chr25_+_35706493 0.23 ENSDART00000176741
kinesin family member 21A
chr12_+_34763795 0.23 ENSDART00000153097
solute carrier family 38, member 10
chr24_+_1294176 0.23 ENSDART00000106637
si:ch73-134f24.1
chr2_-_30987538 0.22 ENSDART00000148157
elastin microfibril interfacer 2a
chr18_-_7112882 0.22 ENSDART00000176292
si:dkey-88e18.8
chr23_-_36418059 0.21 ENSDART00000135232
zinc finger protein 740b
chr18_-_47103131 0.21 ENSDART00000188553

chr2_-_37465517 0.21 ENSDART00000139983
si:dkey-57k2.6
chr6_+_40794015 0.21 ENSDART00000144479
GATA binding protein 2b
chr17_-_33407843 0.20 ENSDART00000129416

chr21_-_24632778 0.20 ENSDART00000132533
ENSDART00000058370
Rho GTPase activating protein 32b
chr23_-_39784368 0.20 ENSDART00000110282
si:ch211-286f9.2
chr23_-_5032587 0.19 ENSDART00000163903
potassium voltage-gated channel, shaker-related subfamily, member 2b
chr4_-_28958601 0.19 ENSDART00000111294
zgc:174315
chr12_-_46176115 0.17 ENSDART00000152848
si:ch211-226h7.8
chr1_-_191971 0.17 ENSDART00000164091
ENSDART00000159237
growth hormone regulated TBC protein 1a
chr18_+_9382847 0.16 ENSDART00000061886
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Ab
chr2_-_144393 0.16 ENSDART00000156008
adenylate cyclase 1b
chr1_+_56873359 0.14 ENSDART00000152713
si:ch211-152f2.2
chr21_-_38853737 0.14 ENSDART00000184100
toll-like receptor 22
chr9_+_23714406 0.13 ENSDART00000189445
glycophorin C (Gerbich blood group)
chr23_-_1144425 0.13 ENSDART00000098271
proteasome subunit beta11b
chr23_-_16692312 0.13 ENSDART00000046784
FK506 binding protein 1Ab
chr15_+_35718354 0.13 ENSDART00000110003
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2a
chr17_+_45602640 0.13 ENSDART00000153822
si:ch211-202f3.4
chr11_+_6159595 0.12 ENSDART00000178367
solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
chr8_+_48858132 0.10 ENSDART00000124737
ENSDART00000079644
tumor protein p73
chr6_+_51779863 0.10 ENSDART00000108534
transmembrane protein 74B
chr16_-_30927764 0.09 ENSDART00000156804
solute carrier family 45, member 4
chr4_+_5193198 0.08 ENSDART00000067388
fibroblast growth factor 23
chr9_-_33081781 0.08 ENSDART00000165748
zgc:172053
chr25_+_21716263 0.07 ENSDART00000148920
zinc finger protein 277
chr4_-_9579299 0.07 ENSDART00000183079
ENSDART00000192968
ENSDART00000091809
SH3 and multiple ankyrin repeat domains 3b
chr20_-_25669813 0.07 ENSDART00000153118
si:dkeyp-117h8.2
chr17_+_25955003 0.07 ENSDART00000156029
glutamate receptor, ionotropic, delta 1a
chr14_+_22129096 0.06 ENSDART00000132514
cyclin G1
chr2_+_5371492 0.06 ENSDART00000139762
si:ch1073-184j22.1
chr7_+_38811800 0.05 ENSDART00000052322
zgc:110699
chr25_+_9003230 0.05 ENSDART00000180330
ENSDART00000142917
recombination activating gene 1
chr9_-_33063083 0.05 ENSDART00000048550
si:ch211-125e6.5
chr10_+_8656417 0.04 ENSDART00000123131
phorbol-12-myristate-13-acetate-induced protein 1
chr4_+_18782840 0.04 ENSDART00000146450
solute carrier family 26 (anion exchanger), member 4
chr2_-_55317035 0.04 ENSDART00000169382
ENSDART00000097874
tropomyosin 4b
chr16_-_47483142 0.04 ENSDART00000147072
collagen triple helix repeat containing 1b
chr25_-_21716326 0.02 ENSDART00000152011
si:dkey-81e3.1
chr4_-_30712588 0.02 ENSDART00000142393
si:dkey-16p19.5
chr6_+_102506 0.02 ENSDART00000172678
low density lipoprotein receptor b
chr22_-_18387059 0.01 ENSDART00000007769
testis-specific serine kinase 6
chr12_-_28548789 0.00 ENSDART00000153062
si:ch73-180n10.1

Network of associatons between targets according to the STRING database.

First level regulatory network of ebf3a-2+ebf3b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.0 GO:0097377 interneuron axon guidance(GO:0097376) spinal cord interneuron axon guidance(GO:0097377) dorsal spinal cord interneuron axon guidance(GO:0097378)
0.9 2.7 GO:1904251 regulation of bile acid biosynthetic process(GO:0070857) regulation of bile acid metabolic process(GO:1904251)
0.4 2.1 GO:0021534 cell proliferation in hindbrain(GO:0021534)
0.4 9.2 GO:0048936 peripheral nervous system neuron axonogenesis(GO:0048936)
0.4 1.6 GO:0003322 pancreatic A cell development(GO:0003322)
0.4 1.2 GO:0021960 anterior commissure morphogenesis(GO:0021960)
0.4 2.1 GO:0035989 tendon development(GO:0035989)
0.3 1.2 GO:0014856 skeletal muscle cell proliferation(GO:0014856) regulation of skeletal muscle cell proliferation(GO:0014857)
0.3 1.6 GO:0035332 positive regulation of hippo signaling(GO:0035332)
0.3 1.1 GO:0003228 atrial cardiac muscle tissue development(GO:0003228)
0.2 0.6 GO:0042416 dopamine biosynthetic process from tyrosine(GO:0006585) dopamine biosynthetic process(GO:0042416)
0.2 1.4 GO:0060017 parathyroid gland development(GO:0060017)
0.2 1.4 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.2 1.4 GO:0090259 regulation of retinal ganglion cell axon guidance(GO:0090259)
0.2 0.8 GO:0050938 regulation of xanthophore differentiation(GO:0050938)
0.1 0.7 GO:0008591 regulation of Wnt signaling pathway, calcium modulating pathway(GO:0008591) positive regulation of convergent extension involved in gastrulation(GO:1904105)
0.1 1.5 GO:0030240 skeletal muscle thin filament assembly(GO:0030240)
0.1 0.9 GO:0033278 cell proliferation in midbrain(GO:0033278)
0.1 1.3 GO:0001973 adenosine receptor signaling pathway(GO:0001973) purinergic receptor signaling pathway(GO:0035587) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.1 0.9 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 0.3 GO:0055107 Golgi to secretory granule transport(GO:0055107)
0.1 1.5 GO:0032438 melanosome organization(GO:0032438)
0.1 0.8 GO:0061620 glucose catabolic process(GO:0006007) NADH regeneration(GO:0006735) glycolytic process through fructose-6-phosphate(GO:0061615) glycolytic process through glucose-6-phosphate(GO:0061620) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.1 1.1 GO:0048899 anterior lateral line development(GO:0048899)
0.1 1.0 GO:0051127 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.1 1.1 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.1 1.7 GO:0016082 synaptic vesicle priming(GO:0016082)
0.1 0.7 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 0.5 GO:0031498 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0 0.3 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.0 0.7 GO:0021884 forebrain neuron development(GO:0021884)
0.0 0.2 GO:0048755 branching morphogenesis of a nerve(GO:0048755)
0.0 3.4 GO:0021782 glial cell development(GO:0021782)
0.0 0.3 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 0.4 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.0 0.8 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.4 GO:0033138 positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.0 0.4 GO:0015701 bicarbonate transport(GO:0015701)
0.0 1.1 GO:0051693 actin filament capping(GO:0051693)
0.0 1.3 GO:0060395 SMAD protein signal transduction(GO:0060395)
0.0 0.2 GO:0006570 tyrosine metabolic process(GO:0006570)
0.0 0.5 GO:0019432 triglyceride biosynthetic process(GO:0019432)
0.0 0.4 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.8 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.2 GO:0016199 axon midline choice point recognition(GO:0016199)
0.0 0.2 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 2.3 GO:0007219 Notch signaling pathway(GO:0007219)
0.0 0.3 GO:0014823 response to activity(GO:0014823)
0.0 0.7 GO:0051781 positive regulation of cell division(GO:0051781)
0.0 0.1 GO:0097107 postsynaptic density assembly(GO:0097107) modulation of excitatory postsynaptic potential(GO:0098815) positive regulation of excitatory postsynaptic potential(GO:2000463)
0.0 0.3 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.1 GO:0030643 cellular anion homeostasis(GO:0030002) cellular monovalent inorganic anion homeostasis(GO:0030320) cellular phosphate ion homeostasis(GO:0030643) cellular divalent inorganic anion homeostasis(GO:0072501) cellular trivalent inorganic anion homeostasis(GO:0072502)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.7 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.2 1.1 GO:0008091 spectrin(GO:0008091)
0.1 1.4 GO:0030057 desmosome(GO:0030057)
0.1 0.8 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.1 1.5 GO:0031430 M band(GO:0031430)
0.1 0.5 GO:0043194 axon initial segment(GO:0043194)
0.1 1.0 GO:0031209 SCAR complex(GO:0031209)
0.1 1.3 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 5.2 GO:0005882 intermediate filament(GO:0005882)
0.0 1.5 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.5 GO:0071564 npBAF complex(GO:0071564)
0.0 0.2 GO:0001650 fibrillar center(GO:0001650)
0.0 1.1 GO:0005861 troponin complex(GO:0005861)
0.0 1.1 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 1.0 GO:0016529 sarcoplasm(GO:0016528) sarcoplasmic reticulum(GO:0016529)
0.0 0.2 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.6 GO:0043204 perikaryon(GO:0043204)
0.0 1.0 GO:0005604 basement membrane(GO:0005604)
0.0 0.2 GO:0046930 pore complex(GO:0046930)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.7 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.2 1.3 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.1 1.0 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 1.1 GO:0031013 troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.1 0.7 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.1 1.1 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 0.6 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.1 0.8 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.1 1.5 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1 1.3 GO:0070411 I-SMAD binding(GO:0070411)
0.1 3.5 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 0.3 GO:0004960 thromboxane receptor activity(GO:0004960)
0.1 2.2 GO:0005109 frizzled binding(GO:0005109)
0.0 0.2 GO:0015288 porin activity(GO:0015288)
0.0 0.5 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
0.0 1.7 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.3 GO:0034452 dynactin binding(GO:0034452)
0.0 1.2 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.6 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.4 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.7 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 12.2 GO:0046983 protein dimerization activity(GO:0046983)
0.0 0.4 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.0 0.7 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.2 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.1 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.0 1.0 GO:0045296 cadherin binding(GO:0045296)
0.0 1.5 GO:0008083 growth factor activity(GO:0008083)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.5 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 1.1 PID ALK2 PATHWAY ALK2 signaling events
0.1 3.4 PID FGF PATHWAY FGF signaling pathway
0.1 0.9 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.0 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.9 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 0.9 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.3 PID NETRIN PATHWAY Netrin-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.4 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.1 1.3 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 1.1 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 0.9 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.1 2.3 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 0.6 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 1.3 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.9 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.3 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.3 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.1 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.8 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0 0.4 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels