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PRJNA195909:zebrafish embryo and larva development

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Results for egr1

Z-value: 0.98

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Transcription factors associated with egr1

Gene Symbol Gene ID Gene Info
egr1
ENSDARG00000037421 early growth response 1
egr1
ENSDARG00000115563 early growth response 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
egr1dr11_v1_chr14_-_21336385_21336385-0.674.7e-02Click!

Activity profile of egr1 motif

Sorted Z-values of egr1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_+_15155684 2.88 ENSDART00000167966
zgc:158852
zgc:158852
chr10_-_34002185 2.77 ENSDART00000046599
zar1l
zygote arrest 1-like
chr19_-_6193448 2.38 ENSDART00000151405
erf
Ets2 repressor factor
chr15_-_17099560 2.14 ENSDART00000101724
mos
v-mos Moloney murine sarcoma viral oncogene homolog
chr3_-_49504023 2.09 ENSDART00000168108
prkacaa
protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a
chr19_-_6193067 2.04 ENSDART00000092656
ENSDART00000140347
erf
Ets2 repressor factor
chr17_+_46387086 1.68 ENSDART00000157079
si:dkey-206p8.1
si:dkey-206p8.1
chr10_-_32851847 1.64 ENSDART00000134255
trim37
tripartite motif containing 37
chr9_+_45227028 1.63 ENSDART00000185579
adarb1b
adenosine deaminase, RNA-specific, B1b
chr22_+_34784075 1.55 ENSDART00000167538
lcor
ligand dependent nuclear receptor corepressor
chr17_-_2584423 1.35 ENSDART00000013506
zp3.2
zona pellucida glycoprotein 3, tandem duplicate 2
chr19_-_2115040 1.31 ENSDART00000020497
snx13
sorting nexin 13
chr21_+_19368720 1.30 ENSDART00000187759
ENSDART00000185829
ENSDART00000158471
ENSDART00000168728
btc
betacellulin, epidermal growth factor family member
chr18_+_15106518 1.29 ENSDART00000168639
cry1ab
cryptochrome circadian clock 1ab
chr7_-_20611039 1.25 ENSDART00000170422
si:dkey-19b23.8
si:dkey-19b23.8
chr23_-_22072460 1.24 ENSDART00000132343
phc2a
polyhomeotic homolog 2a (Drosophila)
chr9_-_54001502 1.21 ENSDART00000085253
mid1
midline 1
chr24_+_26379441 1.20 ENSDART00000137786
si:ch211-230g15.5
si:ch211-230g15.5
chr4_-_277081 1.20 ENSDART00000166174
si:ch73-252i11.1
si:ch73-252i11.1
chr2_-_24603325 1.17 ENSDART00000113356
crtc1a
CREB regulated transcription coactivator 1a
chr20_+_27712714 1.16 ENSDART00000008306
zbtb1
zinc finger and BTB domain containing 1
chr25_+_34889061 1.15 ENSDART00000136226
spire2
spire-type actin nucleation factor 2
chr23_-_22072716 1.12 ENSDART00000054362
phc2a
polyhomeotic homolog 2a (Drosophila)
chr2_+_35880600 1.12 ENSDART00000004277
lamc1
laminin, gamma 1
chr11_+_2855430 1.10 ENSDART00000172837
kif21b
kinesin family member 21B
chr1_-_17693273 1.09 ENSDART00000146258
cfap97
cilia and flagella associated protein 97
chr7_+_46019780 1.09 ENSDART00000163991
ccne1
cyclin E1
chr16_+_13965923 1.09 ENSDART00000103857
zgc:162509
zgc:162509
chr15_-_14038227 1.07 ENSDART00000139068
zgc:114130
zgc:114130
chr2_+_50062165 1.06 ENSDART00000097939
ENSDART00000138214
zcchc2
zinc finger, CCHC domain containing 2
chr5_+_37720777 1.05 ENSDART00000076083
cdc42ep2
CDC42 effector protein (Rho GTPase binding) 2
chr1_-_8917902 1.05 ENSDART00000137900
grin2ab
glutamate receptor, ionotropic, N-methyl D-aspartate 2A, b
chr9_-_41401564 1.05 ENSDART00000059628
nab1b
NGFI-A binding protein 1b (EGR1 binding protein 1)
chr13_-_21739142 0.98 ENSDART00000078460
si:dkey-191g9.5
si:dkey-191g9.5
chr2_+_38924975 0.98 ENSDART00000109219
rem2
RAS (RAD and GEM)-like GTP binding 2
chr18_+_3169579 0.96 ENSDART00000164724
ENSDART00000186340
ENSDART00000181247
ENSDART00000168056
pak1
p21 protein (Cdc42/Rac)-activated kinase 1
chr12_+_47448558 0.95 ENSDART00000185689
ENSDART00000105328
fmn2b
formin 2b
chr23_-_31060350 0.94 ENSDART00000145598
ENSDART00000191491
si:ch211-197l9.5
si:ch211-197l9.5
chr23_+_35426404 0.93 ENSDART00000164658
si:ch211-225h24.2
si:ch211-225h24.2
chr8_+_28724692 0.92 ENSDART00000140115
ccser1
coiled-coil serine-rich protein 1
chr7_+_20563305 0.89 ENSDART00000169661
si:dkey-19b23.10
si:dkey-19b23.10
chr12_-_48943467 0.88 ENSDART00000191829
CABZ01092907.1

chr21_+_3941758 0.88 ENSDART00000181345
setx
senataxin
chr25_-_36370292 0.87 ENSDART00000152766
CR354435.1
Histone H2B 1/2
chr8_+_2642384 0.86 ENSDART00000143242
naif1
nuclear apoptosis inducing factor 1
chr21_-_43398457 0.86 ENSDART00000166530
ccni2
cyclin I family, member 2
chr17_+_34206167 0.84 ENSDART00000136167
mpp5a
membrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5)
chr23_+_45822935 0.83 ENSDART00000161892
vdra
vitamin D receptor a
chr1_+_58977262 0.83 ENSDART00000168832
eri2
ERI1 exoribonuclease family member 2
chr20_+_39250673 0.83 ENSDART00000153003
reps1
RALBP1 associated Eps domain containing 1
chr17_-_25831569 0.83 ENSDART00000148743
hhat
hedgehog acyltransferase
chr16_-_13965518 0.81 ENSDART00000138304
si:dkey-85k15.4
si:dkey-85k15.4
chr18_-_50845804 0.80 ENSDART00000158517
PDPR
si:cabz01113374.3
chr25_+_34888886 0.79 ENSDART00000035245
spire2
spire-type actin nucleation factor 2
chr10_-_14920989 0.79 ENSDART00000184617
smad2
SMAD family member 2
chr11_-_37880492 0.78 ENSDART00000102868
etnk2
ethanolamine kinase 2
chr21_-_41369539 0.78 ENSDART00000187546
cpeb4b
cytoplasmic polyadenylation element binding protein 4b
chr14_-_4044545 0.78 ENSDART00000169527
snx25
sorting nexin 25
chr5_-_67241633 0.77 ENSDART00000114783
clip1a
CAP-GLY domain containing linker protein 1a
chr14_+_17397534 0.76 ENSDART00000180162
ENSDART00000129838
rnf212
ring finger protein 212
chr22_-_16275236 0.75 ENSDART00000149051
cdc14ab
cell division cycle 14Ab
chr3_+_16722014 0.74 ENSDART00000008711
gys1
glycogen synthase 1 (muscle)
chr2_+_23062085 0.74 ENSDART00000153745
csnk1g2a
casein kinase 1, gamma 2a
chr24_+_19542323 0.73 ENSDART00000140379
ENSDART00000142830
sulf1
sulfatase 1
chr2_+_38271392 0.73 ENSDART00000042100
homeza
homeobox and leucine zipper encoding a
chr19_-_25427255 0.72 ENSDART00000036854
glcci1a
glucocorticoid induced 1a
chr21_-_43398122 0.72 ENSDART00000050533
ccni2
cyclin I family, member 2
chr6_-_7776612 0.72 ENSDART00000190269
myh9a
myosin, heavy chain 9a, non-muscle
chr7_+_9326234 0.72 ENSDART00000104536
chsy1
chondroitin sulfate synthase 1
chr16_+_19029297 0.71 ENSDART00000115263
ENSDART00000114954
rapgef5b
Rap guanine nucleotide exchange factor (GEF) 5b
chr5_+_66170479 0.70 ENSDART00000172117
gldc
glycine dehydrogenase (decarboxylating)
chr13_-_49666615 0.69 ENSDART00000148083
tomm20a
translocase of outer mitochondrial membrane 20
chr20_-_22778394 0.68 ENSDART00000152645
fip1l1a
FIP1 like 1a (S. cerevisiae)
chr13_+_50778187 0.67 ENSDART00000159597
dntt
deoxynucleotidyltransferase, terminal
chr17_+_584369 0.64 ENSDART00000165143
C14orf28
chromosome 14 open reading frame 28
chr12_-_37449396 0.64 ENSDART00000152951
cdc42ep4b
CDC42 effector protein (Rho GTPase binding) 4b
chr11_+_1565806 0.64 ENSDART00000137479
mybl2b
v-myb avian myeloblastosis viral oncogene homolog-like 2b
chr9_+_51784922 0.63 ENSDART00000125850
cd302
CD302 molecule
chr2_+_105748 0.63 ENSDART00000169601
CABZ01098670.1

chr20_+_27087539 0.62 ENSDART00000062094
tmem251
transmembrane protein 251
chr1_-_29761086 0.62 ENSDART00000136760
alg11
asparagine-linked glycosylation 11 (alpha-1,2-mannosyltransferase)
chr7_-_24995631 0.61 ENSDART00000173955
ENSDART00000173791
rcor2
REST corepressor 2
chr20_+_28803642 0.61 ENSDART00000188526
fntb
farnesyltransferase, CAAX box, beta
chr11_-_2594045 0.60 ENSDART00000114079
nab2
NGFI-A binding protein 2 (EGR1 binding protein 2)
chr22_+_10713713 0.60 ENSDART00000122349
hiat1b
hippocampus abundant transcript 1b
chr3_+_51684963 0.59 ENSDART00000091180
ENSDART00000183711
ENSDART00000159493
baiap2a
BAI1-associated protein 2a
chr11_+_45461419 0.59 ENSDART00000173424
sos1
son of sevenless homolog 1 (Drosophila)
chr7_+_31051603 0.59 ENSDART00000108721
tjp1a
tight junction protein 1a
chr21_-_41369370 0.58 ENSDART00000159290
cpeb4b
cytoplasmic polyadenylation element binding protein 4b
chr25_+_29688671 0.58 ENSDART00000073478
brd1b
bromodomain containing 1b
chr13_-_36761379 0.57 ENSDART00000131534
ENSDART00000029824
map4k5
mitogen-activated protein kinase kinase kinase kinase 5
chr20_-_46808870 0.56 ENSDART00000190911
esrrgb
estrogen-related receptor gamma b
chr18_+_18612388 0.55 ENSDART00000186455
st3gal2
ST3 beta-galactoside alpha-2,3-sialyltransferase 2
chr12_+_48511605 0.55 ENSDART00000168389
arhgap44
Rho GTPase activating protein 44
chr3_+_1211242 0.54 ENSDART00000171287
ENSDART00000165769
poldip3
polymerase (DNA-directed), delta interacting protein 3
chr23_+_44665230 0.52 ENSDART00000144958
camta2
calmodulin binding transcription activator 2
chr22_-_193234 0.52 ENSDART00000131067
fbxo42
F-box protein 42
chr7_+_28724919 0.52 ENSDART00000011324
ccdc102a
coiled-coil domain containing 102A
chr23_-_16980213 0.52 ENSDART00000046889
dnmt3bb.3
DNA (cytosine-5-)-methyltransferase beta, duplicate b.3
chr9_-_105135 0.51 ENSDART00000180126
FQ377903.3

chr17_+_15983247 0.50 ENSDART00000154275
clmn
calmin
chr16_-_26132122 0.49 ENSDART00000157787
lipeb
lipase, hormone-sensitive b
chr7_-_46019756 0.49 ENSDART00000162583
zgc:162297
zgc:162297
chr23_-_31645760 0.48 ENSDART00000035031
sgk1
serum/glucocorticoid regulated kinase 1
chr25_-_32888115 0.47 ENSDART00000087586
c2cd4a
C2 calcium dependent domain containing 4A
chr3_-_32180796 0.47 ENSDART00000133191
ENSDART00000055308
pih1d1
PIH1 domain containing 1
chr23_-_32100106 0.46 ENSDART00000044658
letmd1
LETM1 domain containing 1
chr22_-_3564563 0.46 ENSDART00000145114
ptprsa
protein tyrosine phosphatase, receptor type, s, a
chr13_-_479129 0.46 ENSDART00000159803
ENSDART00000082127
heatr5b
HEAT repeat containing 5B
chr7_+_31051213 0.45 ENSDART00000148347
tjp1a
tight junction protein 1a
chr4_-_5018705 0.45 ENSDART00000154025
strip2
striatin interacting protein 2
chr20_+_32523576 0.44 ENSDART00000147319
scml4
Scm polycomb group protein like 4
chr12_+_41510492 0.44 ENSDART00000170976
ENSDART00000176164
kif5bb
kinesin family member 5B, b
chr12_+_34273240 0.44 ENSDART00000037904
socs3b
suppressor of cytokine signaling 3b
chr3_-_42016693 0.44 ENSDART00000184741
ttyh3a
tweety family member 3a
chr25_+_36315127 0.42 ENSDART00000191984
zgc:165555
zgc:165555
chr24_-_42072886 0.42 ENSDART00000171389
CABZ01095370.1

chr3_+_1107102 0.42 ENSDART00000092690
srebf2
sterol regulatory element binding transcription factor 2
chr20_+_28803977 0.42 ENSDART00000153351
ENSDART00000038149
fntb
farnesyltransferase, CAAX box, beta
chr4_+_77948517 0.40 ENSDART00000149305
pacsin2
protein kinase C and casein kinase substrate in neurons 2
chr6_+_2271559 0.40 ENSDART00000165223
pbx1b
pre-B-cell leukemia homeobox 1b
chr7_-_52498175 0.38 ENSDART00000129769
cgnl1
cingulin-like 1
chr20_+_46699021 0.38 ENSDART00000167398
ENSDART00000029894
wdr26b
WD repeat domain 26b
chr11_-_42418374 0.37 ENSDART00000160704
slmapa
sarcolemma associated protein a
chr2_+_23701613 0.36 ENSDART00000047073
oxsr1a
oxidative stress responsive 1a
chr21_+_27513859 0.36 ENSDART00000065420
pacs1a
phosphofurin acidic cluster sorting protein 1a
chr21_+_103194 0.36 ENSDART00000162755
zer1
zyg-11 related, cell cycle regulator
chr5_+_72377851 0.36 ENSDART00000160479
lman2la
lectin, mannose-binding 2-like a
chr1_+_49435017 0.36 ENSDART00000124833
pdcd11
programmed cell death 11
chr3_-_5228137 0.36 ENSDART00000137105
myh9b
myosin, heavy chain 9b, non-muscle
chr7_+_5968225 0.35 ENSDART00000083397
zgc:165555
zgc:165555
chr2_+_20793982 0.35 ENSDART00000014785
prg4a
proteoglycan 4a
chr1_+_59146298 0.35 ENSDART00000191885
ENSDART00000152747
gpr108
G protein-coupled receptor 108
chr19_+_935565 0.34 ENSDART00000113368
RNF5
ring finger protein 5
chr1_-_10473630 0.33 ENSDART00000040116
tnrc5
trinucleotide repeat containing 5
chr4_-_5019113 0.33 ENSDART00000189321
ENSDART00000081990
strip2
striatin interacting protein 2
chr20_+_38458084 0.33 ENSDART00000020153
ENSDART00000135912
coq8a
coenzyme Q8A
chr10_+_11282883 0.32 ENSDART00000135355
si:ch211-126i22.5
si:ch211-126i22.5
chr1_+_12295142 0.32 ENSDART00000158595
gne
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
chr11_+_45436703 0.32 ENSDART00000168295
ENSDART00000173293
sos1
son of sevenless homolog 1 (Drosophila)
chr17_+_15983557 0.32 ENSDART00000190806
clmn
calmin
chr25_-_6389713 0.31 ENSDART00000083539
sin3aa
SIN3 transcription regulator family member Aa
chr23_-_270847 0.31 ENSDART00000191867
anks1aa
ankyrin repeat and sterile alpha motif domain containing 1Aa
chr10_+_8554929 0.31 ENSDART00000190849
tbc1d10ab
TBC1 domain family, member 10Ab
chr14_-_7245971 0.30 ENSDART00000108796
stox2b
storkhead box 2b
chr6_+_42338309 0.30 ENSDART00000015277
gpx1b
glutathione peroxidase 1b
chr7_-_66126628 0.30 ENSDART00000184492
btbd10b
BTB (POZ) domain containing 10b
chr19_+_2619444 0.29 ENSDART00000169483
fam126a
family with sequence similarity 126, member A
chr10_-_35030673 0.29 ENSDART00000135338
supt20
SPT20 homolog, SAGA complex component
chr1_+_176583 0.29 ENSDART00000168760
ENSDART00000160425
LAMP1
lysosomal associated membrane protein 1
chr12_-_850457 0.29 ENSDART00000022688
tob1b
transducer of ERBB2, 1b
chr5_-_2689753 0.28 ENSDART00000172699
gng10
guanine nucleotide binding protein (G protein), gamma 10
chr2_-_44344321 0.28 ENSDART00000084174
lig1
ligase I, DNA, ATP-dependent
chr15_+_17406920 0.27 ENSDART00000081059
rps6kb1b
ribosomal protein S6 kinase b, polypeptide 1b
chr7_+_41340520 0.26 ENSDART00000005127
garem
GRB2 associated, regulator of MAPK1
chr25_-_36310561 0.26 ENSDART00000181152
zgc:165555
zgc:165555
chr14_+_164556 0.25 ENSDART00000185606
WDR1
WD repeat domain 1
chr21_+_26620867 0.25 ENSDART00000176008
esrra
estrogen-related receptor alpha
chr19_-_81477 0.25 ENSDART00000159815
hnrnpr
heterogeneous nuclear ribonucleoprotein R
chr21_-_24865217 0.25 ENSDART00000101136
igsf9bb
immunoglobulin superfamily, member 9Bb
chr5_-_21524251 0.24 ENSDART00000176793
ENSDART00000040184
tenm1
teneurin transmembrane protein 1
chr17_+_8323348 0.24 ENSDART00000169900
cdc42bpaa
CDC42 binding protein kinase alpha (DMPK-like) a
chr2_+_16710889 0.23 ENSDART00000017852
ubxn7
UBX domain protein 7
chr6_-_25181012 0.23 ENSDART00000161585
lrrc8db
leucine rich repeat containing 8 VRAC subunit Db
chr2_-_54639964 0.23 ENSDART00000100103
acss2l
acyl-CoA synthetase short chain family member 2 like
chr8_+_20438884 0.22 ENSDART00000016422
ENSDART00000133794
mknk2b
MAP kinase interacting serine/threonine kinase 2b
chr11_+_25296366 0.22 ENSDART00000065949
top1l
DNA topoisomerase I, like
chr21_-_33126697 0.22 ENSDART00000189293
ENSDART00000084559
CU019662.1

chr14_+_48960078 0.21 ENSDART00000165514
mif
macrophage migration inhibitory factor
chr6_+_14301214 0.21 ENSDART00000129491
tmem182b
transmembrane protein 182b
chr7_-_26603743 0.20 ENSDART00000099003
plscr3b
phospholipid scramblase 3b
chr19_+_2602903 0.19 ENSDART00000033132
fam126a
family with sequence similarity 126, member A
chr1_-_52505279 0.19 ENSDART00000052907
acy3.1
aspartoacylase (aminocyclase) 3, tandem duplicate 1
chr6_-_13498745 0.19 ENSDART00000027684
ENSDART00000189438
mylkb
myosin light chain kinase b
chr2_-_50272077 0.19 ENSDART00000127623
cul1a
cullin 1a
chr17_+_20639180 0.19 ENSDART00000063624
npy4r
neuropeptide Y receptor Y4
chr22_+_1751640 0.19 ENSDART00000162093
znf1169
zinc finger protein 1169
chr25_-_13050959 0.19 ENSDART00000169041
ccl35.1
chemokine (C-C motif) ligand 35, duplicate 1
chr7_-_12596727 0.19 ENSDART00000186413
adamtsl3
ADAMTS-like 3
chr11_+_45461853 0.19 ENSDART00000173409
sos1
son of sevenless homolog 1 (Drosophila)
chr11_-_31146808 0.18 ENSDART00000172781
si:cabz01069582.1
si:cabz01069582.1
chr1_-_7917062 0.18 ENSDART00000177068
mmd2b
monocyte to macrophage differentiation-associated 2b
chr24_+_32472155 0.18 ENSDART00000098859
neurod6a
neuronal differentiation 6a
chr17_-_14726824 0.18 ENSDART00000162947
si:ch73-305o9.3
si:ch73-305o9.3
chr22_+_15979430 0.18 ENSDART00000189703
ENSDART00000192674
rc3h1a
ring finger and CCCH-type domains 1a
chr2_+_59046036 0.17 ENSDART00000158860
stk11
serine/threonine kinase 11
chr8_-_15292197 0.17 ENSDART00000140867
spata6
spermatogenesis associated 6
chr6_-_57408576 0.17 ENSDART00000163930
znfx1
zinc finger, NFX1-type containing 1
chr25_-_7999756 0.17 ENSDART00000159908
camk1db
calcium/calmodulin-dependent protein kinase 1Db
chr20_-_26624042 0.17 ENSDART00000077962
exoc2
exocyst complex component 2
chr22_-_6499055 0.17 ENSDART00000142235
ENSDART00000183588
si:dkey-19a16.7
si:dkey-19a16.7
chr14_-_15155384 0.16 ENSDART00000172666
uvssa
UV-stimulated scaffold protein A
chr17_+_53435279 0.16 ENSDART00000126630
cx52.9
connexin 52.9
chr19_+_7154500 0.15 ENSDART00000035967
ENSDART00000160894
brd2a
bromodomain containing 2a
chr19_-_3303995 0.14 ENSDART00000105150
si:ch211-133n4.9
si:ch211-133n4.9
chr22_-_10605045 0.14 ENSDART00000184812
bap1
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
chr6_+_34511886 0.14 ENSDART00000179450
lrp8
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
chr5_+_65492183 0.14 ENSDART00000162804
si:dkey-21e5.1
si:dkey-21e5.1
chr16_-_8520474 0.13 ENSDART00000137365
grb10b
growth factor receptor-bound protein 10b
chr6_+_13206516 0.13 ENSDART00000036927
ndufs1
NADH dehydrogenase (ubiquinone) Fe-S protein 1

Network of associatons between targets according to the STRING database.

First level regulatory network of egr1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:1902102 meiotic cell cycle phase transition(GO:0044771) metaphase/anaphase transition of meiotic cell cycle(GO:0044785) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994) regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902102) negative regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902103) regulation of meiotic chromosome separation(GO:1905132) negative regulation of meiotic chromosome separation(GO:1905133)
0.6 1.7 GO:0090004 positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.4 1.1 GO:0010657 negative regulation of muscle cell apoptotic process(GO:0010656) muscle cell apoptotic process(GO:0010657) striated muscle cell apoptotic process(GO:0010658) regulation of muscle cell apoptotic process(GO:0010660) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664)
0.3 1.0 GO:0018343 protein farnesylation(GO:0018343)
0.2 1.9 GO:0040038 meiotic cytokinesis(GO:0033206) polar body extrusion after meiotic divisions(GO:0040038)
0.2 1.6 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.2 2.1 GO:0071331 cellular response to carbohydrate stimulus(GO:0071322) cellular response to monosaccharide stimulus(GO:0071326) cellular response to hexose stimulus(GO:0071331) cellular response to glucose stimulus(GO:0071333)
0.2 0.8 GO:0016332 establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
0.2 0.7 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.2 1.7 GO:0031269 pseudopodium organization(GO:0031268) pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.2 1.2 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.2 0.8 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.2 1.0 GO:0003232 bulbus arteriosus development(GO:0003232)
0.1 1.3 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) positive regulation of receptor activity(GO:2000273)
0.1 0.7 GO:0072103 renal system vasculature morphogenesis(GO:0061438) kidney vasculature morphogenesis(GO:0061439) glomerulus vasculature morphogenesis(GO:0072103) glomerular capillary formation(GO:0072104)
0.1 1.6 GO:0006382 adenosine to inosine editing(GO:0006382)
0.1 0.8 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.1 0.8 GO:0031116 positive regulation of microtubule polymerization(GO:0031116)
0.1 0.9 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.1 0.7 GO:0060876 semicircular canal formation(GO:0060876)
0.1 1.0 GO:0036060 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.1 0.3 GO:1901187 regulation of ephrin receptor signaling pathway(GO:1901187)
0.1 1.1 GO:0050962 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.1 0.7 GO:2000290 smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021910) regulation of myotome development(GO:2000290)
0.1 0.6 GO:0032475 otolith formation(GO:0032475)
0.1 1.4 GO:0035803 binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.1 0.7 GO:0098789 mRNA cleavage involved in mRNA processing(GO:0098787) pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.1 0.8 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.1 0.5 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.1 0.6 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.1 0.4 GO:0070650 actin filament bundle distribution(GO:0070650)
0.1 0.3 GO:0006266 DNA ligation(GO:0006266) DNA ligation involved in DNA repair(GO:0051103)
0.1 0.7 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.1 0.9 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.1 0.8 GO:0055117 regulation of cardiac muscle contraction(GO:0055117)
0.0 0.3 GO:0010269 response to selenium ion(GO:0010269)
0.0 2.2 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 0.4 GO:0010885 regulation of cholesterol storage(GO:0010885)
0.0 0.6 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.0 0.6 GO:0044154 histone H3-K14 acetylation(GO:0044154)
0.0 0.4 GO:0044857 membrane raft assembly(GO:0001765) membrane raft organization(GO:0031579) plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) caveola assembly(GO:0070836)
0.0 1.0 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.0 0.2 GO:0006083 acetate metabolic process(GO:0006083) acetyl-CoA biosynthetic process from acetate(GO:0019427)
0.0 0.1 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520) monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.0 0.7 GO:0060079 excitatory postsynaptic potential(GO:0060079)
0.0 0.1 GO:0015824 proline transport(GO:0015824)
0.0 0.5 GO:0021988 olfactory bulb development(GO:0021772) olfactory lobe development(GO:0021988)
0.0 0.8 GO:1903845 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.0 1.8 GO:0016575 histone deacetylation(GO:0016575)
0.0 0.5 GO:0019433 triglyceride catabolic process(GO:0019433)
0.0 0.1 GO:0071276 cellular response to cadmium ion(GO:0071276)
0.0 0.8 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.7 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)
0.0 0.2 GO:0031048 chromatin silencing by small RNA(GO:0031048)
0.0 0.2 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.0 0.7 GO:0072310 glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.0 0.1 GO:0046627 negative regulation of insulin receptor signaling pathway(GO:0046627) negative regulation of cellular response to insulin stimulus(GO:1900077)
0.0 0.1 GO:1903358 regulation of Golgi organization(GO:1903358)
0.0 0.2 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.0 0.1 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.0 0.3 GO:0006047 UDP-N-acetylglucosamine metabolic process(GO:0006047)
0.0 0.7 GO:0009250 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0 0.8 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.2 GO:0006265 DNA topological change(GO:0006265)
0.0 7.3 GO:0045892 negative regulation of transcription, DNA-templated(GO:0045892)
0.0 1.0 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.9 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.4 GO:0060349 bone morphogenesis(GO:0060349)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0097134 cyclin E1-CDK2 complex(GO:0097134)
0.3 1.0 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.2 1.6 GO:0016234 inclusion body(GO:0016234)
0.2 0.7 GO:0005960 glycine cleavage complex(GO:0005960)
0.2 2.1 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 3.6 GO:0035102 PRC1 complex(GO:0035102)
0.1 0.8 GO:1902636 kinociliary basal body(GO:1902636)
0.1 0.5 GO:0097255 R2TP complex(GO:0097255)
0.1 1.1 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 0.7 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.7 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.7 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.8 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.8 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.2 GO:0097224 sperm connecting piece(GO:0097224)
0.0 0.6 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.8 GO:0000795 synaptonemal complex(GO:0000795)
0.0 0.8 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.3 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.4 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 1.1 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 1.5 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.9 GO:0044853 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.0 0.1 GO:0035517 PR-DUB complex(GO:0035517)
0.0 2.1 GO:0000786 nucleosome(GO:0000786)
0.0 0.3 GO:0000124 SAGA complex(GO:0000124)
0.0 0.1 GO:0090443 FAR/SIN/STRIPAK complex(GO:0090443)
0.0 0.3 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.0 2.0 GO:0016459 myosin complex(GO:0016459)
0.0 1.5 GO:0005795 Golgi stack(GO:0005795)
0.0 1.1 GO:0005871 kinesin complex(GO:0005871)
0.0 1.7 GO:0098791 Golgi subcompartment(GO:0098791)
0.0 0.4 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 4.4 GO:0001130 bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding(GO:0001130) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217)
0.4 1.7 GO:0071253 connexin binding(GO:0071253)
0.4 2.1 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.3 0.9 GO:0001160 transcription termination site sequence-specific DNA binding(GO:0001147) transcription termination site DNA binding(GO:0001160)
0.3 0.8 GO:0005499 vitamin D binding(GO:0005499)
0.3 1.0 GO:0004660 protein farnesyltransferase activity(GO:0004660)
0.2 0.6 GO:0004377 GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity(GO:0004377)
0.2 0.7 GO:0004373 glycogen (starch) synthase activity(GO:0004373)
0.2 1.2 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 1.6 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.1 1.4 GO:0035804 structural constituent of egg coat(GO:0035804)
0.1 0.3 GO:0008761 UDP-N-acetylglucosamine 2-epimerase activity(GO:0008761) N-acylmannosamine kinase activity(GO:0009384)
0.1 0.6 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.1 0.3 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.1 0.7 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.1 0.6 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1 0.7 GO:0016594 glycine binding(GO:0016594)
0.1 0.5 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.1 0.2 GO:0032027 myosin light chain binding(GO:0032027)
0.1 1.3 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 1.1 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 1.6 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.4 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.0 0.7 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.6 GO:0010484 H3 histone acetyltransferase activity(GO:0010484) histone acetyltransferase activity (H3-K23 specific)(GO:0043994)
0.0 0.8 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.7 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.5 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.6 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.8 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.2 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 2.2 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.8 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.7 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.4 GO:0005537 mannose binding(GO:0005537)
0.0 0.8 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 0.2 GO:0035613 RNA stem-loop binding(GO:0035613)
0.0 1.2 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.3 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.8 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 4.0 GO:0042393 histone binding(GO:0042393)
0.0 0.2 GO:0004046 aminoacylase activity(GO:0004046)
0.0 0.2 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.0 0.2 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.7 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 2.1 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.3 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.1 GO:0039706 co-receptor binding(GO:0039706)
0.0 0.2 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.0 0.3 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.2 GO:0031726 CCR1 chemokine receptor binding(GO:0031726) CCR4 chemokine receptor binding(GO:0031729)
0.0 0.3 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.4 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.4 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.8 GO:0016409 palmitoyltransferase activity(GO:0016409)
0.0 3.1 GO:0003774 motor activity(GO:0003774)
0.0 0.5 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 2.3 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 1.6 GO:0008134 transcription factor binding(GO:0008134)
0.0 0.1 GO:0005158 insulin receptor binding(GO:0005158)
0.0 0.2 GO:0004983 neuropeptide Y receptor activity(GO:0004983)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 ST G ALPHA S PATHWAY G alpha s Pathway
0.1 1.3 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 3.2 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.1 1.1 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 1.0 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.1 1.1 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 0.8 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.8 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.7 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 0.7 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 1.0 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 0.4 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 1.4 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.6 PID TNF PATHWAY TNF receptor signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.4 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.1 1.0 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.1 0.8 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.1 0.8 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 0.6 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 0.8 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.1 0.7 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 1.1 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 0.3 REACTOME EARLY PHASE OF HIV LIFE CYCLE Genes involved in Early Phase of HIV Life Cycle
0.0 0.6 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 1.1 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.0 0.3 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.2 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 0.7 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism