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PRJNA195909:zebrafish embryo and larva development
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Results for fosaa+fosab+fosl1a
Z-value: 3.25
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Transcription factors associated with fosaa+fosab+fosl1a
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| fosab | dr11_v1_chr20_-_46554440_46554440 | -0.78 | 1.3e-02 | Click! |
| fosaa | dr11_v1_chr17_-_50234004_50234004 | -0.77 | 1.6e-02 | Click! |
| fosl1a | dr11_v1_chr14_-_30747686_30747686 | -0.71 | 3.1e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_60886984 Show fit | 14.25 |
ENSDART00000170974
|
phosphatidylinositol transfer protein, cytoplasmic 1 |
|
| chr1_-_33647138 Show fit | 5.40 |
ENSDART00000142111
ENSDART00000015547 |
claudin g |
|
| chr23_-_893547 Show fit | 5.26 |
ENSDART00000136805
|
RNA binding motif protein 10 |
|
| chr19_+_14109348 Show fit | 5.22 |
ENSDART00000159015
|
zgc:175136 |
|
| chr11_+_29537756 Show fit | 5.00 |
ENSDART00000103388
|
wu:fi42e03 |
|
| chr9_+_29548195 Show fit | 4.74 |
ENSDART00000176057
|
ring finger protein 17 |
|
| chr13_-_4848889 Show fit | 4.24 |
ENSDART00000165259
|
mitochondrial calcium uniporter |
|
| chr24_+_10027902 Show fit | 4.19 |
ENSDART00000175961
ENSDART00000172773 |
si:ch211-146l10.8 |
|
| chr24_-_10006158 Show fit | 3.91 |
ENSDART00000106244
|
zgc:171750 |
|
| chr9_+_29548630 Show fit | 3.89 |
ENSDART00000132295
|
ring finger protein 17 |
Network of associatons between targets according to the STRING database.
First level regulatory network of fosaa+fosab+fosl1a
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 10.1 | GO:0009648 | photoperiodism(GO:0009648) |
| 0.1 | 7.7 | GO:0031122 | cytoplasmic microtubule organization(GO:0031122) |
| 0.2 | 7.6 | GO:0032007 | negative regulation of TOR signaling(GO:0032007) |
| 0.5 | 6.9 | GO:0060236 | regulation of mitotic spindle organization(GO:0060236) |
| 0.1 | 6.8 | GO:0016579 | protein deubiquitination(GO:0016579) |
| 0.8 | 6.1 | GO:0051673 | membrane disruption in other organism(GO:0051673) |
| 0.2 | 6.1 | GO:0031100 | organ regeneration(GO:0031100) |
| 0.0 | 6.0 | GO:0043484 | regulation of RNA splicing(GO:0043484) |
| 0.7 | 5.7 | GO:0045835 | negative regulation of meiotic nuclear division(GO:0045835) |
| 0.3 | 5.5 | GO:0007032 | endosome organization(GO:0007032) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.5 | GO:0005813 | centrosome(GO:0005813) |
| 0.2 | 18.4 | GO:0000786 | nucleosome(GO:0000786) |
| 0.2 | 8.8 | GO:0005657 | replication fork(GO:0005657) |
| 0.0 | 7.4 | GO:0005730 | nucleolus(GO:0005730) |
| 0.0 | 6.7 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.1 | 6.0 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.1 | 5.9 | GO:0000922 | spindle pole(GO:0000922) |
| 1.6 | 4.7 | GO:0097125 | cyclin B1-CDK1 complex(GO:0097125) |
| 0.1 | 4.5 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.0 | 4.4 | GO:0005923 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.2 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 0.1 | 17.0 | GO:0042802 | identical protein binding(GO:0042802) |
| 0.1 | 6.4 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005) |
| 0.1 | 6.2 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.1 | 5.6 | GO:0051959 | dynein light intermediate chain binding(GO:0051959) |
| 0.6 | 5.5 | GO:0035925 | AU-rich element binding(GO:0017091) mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.0 | 5.5 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 0.0 | 5.3 | GO:0019901 | protein kinase binding(GO:0019901) |
| 1.0 | 5.0 | GO:0043139 | 5'-3' DNA helicase activity(GO:0043139) |
| 0.1 | 4.6 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 24.8 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.4 | 13.6 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.1 | 6.6 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.2 | 5.7 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 5.3 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.2 | 4.2 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.1 | 3.4 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 3.3 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.2 | 2.6 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.1 | 2.4 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 10.6 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.3 | 6.9 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.3 | 6.1 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 6.1 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 5.9 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.1 | 5.5 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 3.9 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.3 | 3.8 | REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |
| 0.1 | 3.7 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.2 | 3.6 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |