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PRJNA195909:zebrafish embryo and larva development

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Results for fosb+fosl2+si:ch211-153j24.3

Z-value: 0.86

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Transcription factors associated with fosb+fosl2+si:ch211-153j24.3

Gene Symbol Gene ID Gene Info
fosl2
ENSDARG00000040623 fos-like antigen 2
fosb
ENSDARG00000055751 FBJ murine osteosarcoma viral oncogene homolog B
si_ch211-153j24.3
ENSDARG00000068428 si_ch211-153j24.3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
si:ch211-153j24.3dr11_v1_chr20_+_46560258_465602580.481.9e-01Click!
fosbdr11_v1_chr18_+_36770166_367701660.215.9e-01Click!
fosl2dr11_v1_chr17_+_41302660_413026600.127.7e-01Click!

Activity profile of fosb+fosl2+si:ch211-153j24.3 motif

Sorted Z-values of fosb+fosl2+si:ch211-153j24.3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_24681292 1.64 ENSDART00000089601
olfml3b
olfactomedin-like 3b
chr9_-_11560110 1.50 ENSDART00000176941
cryba2b
crystallin, beta A2b
chr3_-_61185746 1.48 ENSDART00000028219
pvalb4
parvalbumin 4
chr13_+_24280380 1.37 ENSDART00000184115
acta1b
actin, alpha 1b, skeletal muscle
chr6_-_13783604 1.30 ENSDART00000149536
ENSDART00000041269
ENSDART00000150102
cryba2a
crystallin, beta A2a
chr9_-_11560427 1.27 ENSDART00000127942
ENSDART00000061442
cryba2b
crystallin, beta A2b
chr22_-_26595027 1.05 ENSDART00000184162
CABZ01072309.1

chr2_+_48288461 0.96 ENSDART00000141495
hes6
hes family bHLH transcription factor 6
chr16_+_23403602 0.93 ENSDART00000159848
s100w
S100 calcium binding protein W
chr7_-_8417315 0.85 ENSDART00000173046
jac1
jacalin 1
chr20_-_26532167 0.85 ENSDART00000061914
mthfd1l
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like
chr6_+_29791164 0.84 ENSDART00000017424
ptmaa
prothymosin, alpha a
chr16_-_21785261 0.84 ENSDART00000078858
si:ch73-86n18.1
si:ch73-86n18.1
chr11_-_18253111 0.82 ENSDART00000125984
mustn1b
musculoskeletal, embryonic nuclear protein 1b
chr25_+_13191391 0.81 ENSDART00000109937
si:ch211-147m6.2
si:ch211-147m6.2
chr7_+_8543317 0.81 ENSDART00000114998
jac8
jacalin 8
chr7_-_8490886 0.81 ENSDART00000159012
jac6
jacalin 6
chr21_-_44512893 0.78 ENSDART00000166853
zgc:136410
zgc:136410
chr23_+_35714574 0.78 ENSDART00000164616
tuba1c
tubulin, alpha 1c
chr7_-_8504355 0.75 ENSDART00000173067
loc564660
hypothetical protein LOC564660
chr21_+_22845317 0.74 ENSDART00000065555
birc2
baculoviral IAP repeat containing 2
chr19_-_103289 0.73 ENSDART00000143118
adgrb1b
adhesion G protein-coupled receptor B1b
chr5_-_25582721 0.72 ENSDART00000123986
anxa1a
annexin A1a
chr3_+_24197934 0.71 ENSDART00000055609
atf4b
activating transcription factor 4b
chr19_+_7567763 0.71 ENSDART00000140411
s100a11
S100 calcium binding protein A11
chr18_-_5595546 0.70 ENSDART00000191825
cyp1a
cytochrome P450, family 1, subfamily A
chr21_-_30545121 0.70 ENSDART00000019199
rab39ba
RAB39B, member RAS oncogene family a
chr18_+_46382484 0.70 ENSDART00000024202
ENSDART00000142790
daw1
dynein assembly factor with WDR repeat domains 1
chr16_+_42829735 0.69 ENSDART00000014956
polr3glb
polymerase (RNA) III (DNA directed) polypeptide G like b
chr11_+_13630107 0.68 ENSDART00000172220
si:ch211-1a19.3
si:ch211-1a19.3
chr12_-_212843 0.68 ENSDART00000083574
CABZ01102039.1

chr13_+_50368668 0.67 ENSDART00000127610
dnajc12
DnaJ (Hsp40) homolog, subfamily C, member 12
chr13_+_23988442 0.67 ENSDART00000010918
agt
angiotensinogen
chr19_+_5072918 0.67 ENSDART00000037126
eno2
enolase 2
chr20_+_26880668 0.67 ENSDART00000077769
serpinb1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr22_-_15593824 0.66 ENSDART00000123125
tpm4a
tropomyosin 4a
chr20_-_26531850 0.66 ENSDART00000183317
ENSDART00000131994
mthfd1l
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like
chr2_+_30379650 0.65 ENSDART00000129542
crispld1b
cysteine-rich secretory protein LCCL domain containing 1b
chr1_-_22861348 0.62 ENSDART00000139412
SMIM18
si:dkey-92j12.6
chr7_-_8602864 0.61 ENSDART00000173291
jac2
jacalin 2
chr7_-_8438657 0.61 ENSDART00000173054
si:dkeyp-32g11.8
si:dkeyp-32g11.8
chr2_+_26179096 0.60 ENSDART00000024662
plppr3a
phospholipid phosphatase related 3a
chr7_+_25033924 0.58 ENSDART00000170873
sb:cb1058
sb:cb1058
chr1_-_40914752 0.57 ENSDART00000113087
hmx1
H6 family homeobox 1
chr16_+_42830152 0.57 ENSDART00000159730
polr3glb
polymerase (RNA) III (DNA directed) polypeptide G like b
chr2_-_50298337 0.57 ENSDART00000155125
cntnap2b
contactin associated protein like 2b
chr23_-_39636195 0.56 ENSDART00000144439
vwa1
von Willebrand factor A domain containing 1
chr9_+_22080122 0.56 ENSDART00000065956
ENSDART00000136014
crygm2e
crystallin, gamma M2e
chr25_+_21832938 0.56 ENSDART00000148299
ckmt1
creatine kinase, mitochondrial 1
chr12_+_25945560 0.55 ENSDART00000109799
mmrn2b
multimerin 2b
chr10_+_4987766 0.55 ENSDART00000121959
si:ch73-234b20.5
si:ch73-234b20.5
chr7_-_8577190 0.54 ENSDART00000173174
jac3
jacalin 3
chr25_-_22187397 0.53 ENSDART00000123211
ENSDART00000139110
pkp3a
plakophilin 3a
chr25_-_173165 0.53 ENSDART00000193594
CABZ01114053.1

chr25_+_13191615 0.51 ENSDART00000168849
si:ch211-147m6.2
si:ch211-147m6.2
chr5_-_66028714 0.50 ENSDART00000022625
ENSDART00000164228
nrarpb
NOTCH regulated ankyrin repeat protein b
chr11_+_26609110 0.49 ENSDART00000042322
map1lc3a
microtubule-associated protein 1 light chain 3 alpha
chr6_-_24143923 0.48 ENSDART00000157948
si:ch73-389b16.1
si:ch73-389b16.1
chr11_+_13629528 0.48 ENSDART00000186509
si:ch211-1a19.3
si:ch211-1a19.3
chr16_+_20915319 0.48 ENSDART00000079383
hoxa9b
homeobox A9b
chr14_-_11456724 0.46 ENSDART00000110424
si:ch211-153b23.4
si:ch211-153b23.4
chr25_-_18249751 0.46 ENSDART00000153950
si:dkey-106n21.1
si:dkey-106n21.1
chr7_+_23875269 0.46 ENSDART00000101406
rab39bb
RAB39B, member RAS oncogene family b
chr6_+_56147812 0.44 ENSDART00000150219
tfap2c
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
chr16_+_23960744 0.44 ENSDART00000058965
apoeb
apolipoprotein Eb
chr4_-_6809323 0.43 ENSDART00000099467
ifrd1
interferon-related developmental regulator 1
chr12_+_2399130 0.43 ENSDART00000075179
vstm4b
V-set and transmembrane domain containing 4b
chr9_-_710896 0.42 ENSDART00000180478
ndufb3
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3
chr1_+_14253118 0.42 ENSDART00000161996
cxcl8a
chemokine (C-X-C motif) ligand 8a
chr1_-_33380340 0.40 ENSDART00000181515
cd99
CD99 molecule
chr20_-_42972599 0.40 ENSDART00000100751
pomcb
proopiomelanocortin b
chr14_+_33882973 0.40 ENSDART00000019396
clic2
chloride intracellular channel 2
chr9_-_9992697 0.39 ENSDART00000123415
ugt1ab
UDP glucuronosyltransferase 1 family a, b
chr11_+_21050326 0.39 ENSDART00000065984
zgc:113307
zgc:113307
chr2_-_985417 0.39 ENSDART00000140540
si:ch211-241e1.3
si:ch211-241e1.3
chr2_+_42236118 0.38 ENSDART00000114162
ENSDART00000141199
ftr02
finTRIM family, member 2
chr7_-_8515550 0.38 ENSDART00000111896
jac9
jacalin 9
chr4_+_77735212 0.38 ENSDART00000160716
si:dkey-238k10.1
si:dkey-238k10.1
chr25_+_21324588 0.36 ENSDART00000151842
lrrn3a
leucine rich repeat neuronal 3a
chr10_-_27566481 0.36 ENSDART00000078920
auts2a
autism susceptibility candidate 2a
chr7_+_20298333 0.36 ENSDART00000023089
ENSDART00000131019
acadvl
acyl-CoA dehydrogenase very long chain
chr19_-_7420867 0.36 ENSDART00000081741
rab25a
RAB25, member RAS oncogene family a
chr18_-_15771551 0.35 ENSDART00000130931
ENSDART00000154079
si:ch211-219a15.3
si:ch211-219a15.3
chr10_+_31222656 0.35 ENSDART00000140988
ENSDART00000143387
tmem218
transmembrane protein 218
chr1_-_59411901 0.35 ENSDART00000167015
si:ch211-188p14.4
si:ch211-188p14.4
chr20_+_19066596 0.34 ENSDART00000130271
sox7
SRY (sex determining region Y)-box 7
chr23_-_29376859 0.34 ENSDART00000146411
sst6
somatostatin 6
chr9_-_34915351 0.33 ENSDART00000100728
ENSDART00000139608
upf3a
UPF3A, regulator of nonsense mediated mRNA decay
chr1_-_52498146 0.33 ENSDART00000122217
acy3.2
aspartoacylase (aminocyclase) 3, tandem duplicate 2
chr8_+_31119548 0.33 ENSDART00000136578
syn1
synapsin I
chr4_+_16715267 0.32 ENSDART00000143849
pkp2
plakophilin 2
chr17_-_28707898 0.32 ENSDART00000135752
ENSDART00000061853
ap4s1
adaptor-related protein complex 4, sigma 1 subunit
chr19_+_22216778 0.32 ENSDART00000052521
nfatc1
nuclear factor of activated T cells 1
chr16_+_9762261 0.32 ENSDART00000020654
psmd4b
proteasome 26S subunit, non-ATPase 4b
chr7_+_53541173 0.32 ENSDART00000159449
gramd2aa
GRAM domain containing 2Aa
chr23_+_9067131 0.32 ENSDART00000144533
ccm2l
cerebral cavernous malformation 2-like
chr5_-_9073433 0.31 ENSDART00000099891
atp5meb
ATP synthase membrane subunit eb
chr22_+_16497670 0.31 ENSDART00000014330
ier5
immediate early response 5
chr24_-_36826504 0.31 ENSDART00000112694
fam171a2b
family with sequence similarity 171, member A2b
chr22_-_5006801 0.30 ENSDART00000106166
rx1
retinal homeobox gene 1
chr8_-_20291922 0.30 ENSDART00000148304
myo1f
myosin IF
chr20_-_25626198 0.30 ENSDART00000126716
paics
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr5_+_38276582 0.30 ENSDART00000158532
gnb2
guanine nucleotide binding protein (G protein), beta polypeptide 2
chr5_-_66028371 0.30 ENSDART00000183012
nrarpb
NOTCH regulated ankyrin repeat protein b
chr1_+_41588170 0.29 ENSDART00000139175
si:dkey-56e3.2
si:dkey-56e3.2
chr17_-_2945592 0.29 ENSDART00000174899
C14orf132
chromosome 14 open reading frame 132
chr14_+_49382180 0.29 ENSDART00000158329
tnip1
TNFAIP3 interacting protein 1
chr4_-_76488854 0.29 ENSDART00000132323
ftr51
finTRIM family, member 51
chr25_-_22191733 0.28 ENSDART00000067478
pkp3a
plakophilin 3a
chr20_+_19066858 0.28 ENSDART00000192086
sox7
SRY (sex determining region Y)-box 7
chr2_-_17827983 0.28 ENSDART00000166518
ptprfb
protein tyrosine phosphatase, receptor type, f, b
chr19_-_33212023 0.27 ENSDART00000189209
trib1
tribbles pseudokinase 1
chr13_-_37122217 0.27 ENSDART00000133242
syne2b
spectrin repeat containing, nuclear envelope 2b
chr1_+_59073436 0.27 ENSDART00000161642
MFAP4 (1 of many)
si:zfos-2330d3.3
chr18_+_14477740 0.27 ENSDART00000146472
kcng4a
potassium voltage-gated channel, subfamily G, member 4a
chr10_-_13239367 0.26 ENSDART00000001253
si:busm1-57f23.1
si:busm1-57f23.1
chr23_-_30045661 0.26 ENSDART00000122239
ENSDART00000103480
ccdc187
coiled-coil domain containing 187
chr2_-_17828279 0.26 ENSDART00000083314
ptprfb
protein tyrosine phosphatase, receptor type, f, b
chr7_+_36041509 0.26 ENSDART00000162850
irx3a
iroquois homeobox 3a
chr7_+_60551133 0.25 ENSDART00000148038
lrfn4b
leucine rich repeat and fibronectin type III domain containing 4b
chr25_+_8955530 0.25 ENSDART00000156444
si:ch211-256a21.4
si:ch211-256a21.4
chr11_+_77526 0.25 ENSDART00000193521
CABZ01072242.1

chr23_+_3731375 0.25 ENSDART00000141782
smim29
small integral membrane protein 29
chr8_+_44358443 0.25 ENSDART00000189130
ENSDART00000189212
CU914776.2

chr13_+_49175947 0.25 ENSDART00000056927
egln1a
egl-9 family hypoxia-inducible factor 1a
chr17_-_20711735 0.24 ENSDART00000150056
ank3b
ankyrin 3b
chr5_+_15819651 0.24 ENSDART00000081230
ENSDART00000186969
ENSDART00000134206
hspb8
heat shock protein b8
chr7_-_52963493 0.24 ENSDART00000052029
cart3
cocaine- and amphetamine-regulated transcript 3
chr24_-_6078222 0.23 ENSDART00000146830
apbb1ip
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr10_+_26747755 0.23 ENSDART00000100329
f9b
coagulation factor IXb
chr1_+_2190714 0.23 ENSDART00000132126
mbnl2
muscleblind-like splicing regulator 2
chr9_+_41024973 0.23 ENSDART00000014660
ENSDART00000144467
ormdl1
ORMDL sphingolipid biosynthesis regulator 1
chr1_+_45323142 0.23 ENSDART00000132210
emp1
epithelial membrane protein 1
chr21_+_5636008 0.23 ENSDART00000158385
shroom3
shroom family member 3
chr5_+_38200807 0.23 ENSDART00000100769
hsd20b2
hydroxysteroid (20-beta) dehydrogenase 2
chr1_-_47771742 0.22 ENSDART00000101079
neurl1aa
neuralized E3 ubiquitin protein ligase 1Aa
chr11_+_24251141 0.22 ENSDART00000182684
pnp4a
purine nucleoside phosphorylase 4a
chr13_+_18533005 0.22 ENSDART00000136024
ftr14l
finTRIM family, member 14-like
chr3_-_48259289 0.22 ENSDART00000160717
znf750
zinc finger protein 750
chr4_-_13902188 0.22 ENSDART00000032805
gxylt1b
glucoside xylosyltransferase 1b
chr10_+_31222433 0.22 ENSDART00000185080
tmem218
transmembrane protein 218
chr4_-_19742300 0.21 ENSDART00000066964
ENSDART00000100952
hgfa
hepatocyte growth factor a
chr19_-_32641725 0.21 ENSDART00000165006
ENSDART00000188185
hpca
hippocalcin
chr8_+_20950401 0.21 ENSDART00000136484
ENSDART00000131329
ENSDART00000144451
ENSDART00000144929
si:dkeyp-82a1.1
si:dkeyp-82a1.1
chr13_-_15982707 0.21 ENSDART00000186911
ENSDART00000181072
ikzf1
IKAROS family zinc finger 1 (Ikaros)
chr19_-_31402429 0.21 ENSDART00000137292
tmem106bb
transmembrane protein 106Bb
chr17_-_26868169 0.21 ENSDART00000157204
si:dkey-221l4.10
si:dkey-221l4.10
chr9_-_27805801 0.21 ENSDART00000140608
ENSDART00000114542
si:rp71-45g20.10
si:rp71-45g20.10
chr16_-_28878080 0.21 ENSDART00000149501
si:dkey-239n17.4
si:dkey-239n17.4
chr1_+_8601935 0.20 ENSDART00000152367
si:ch211-160d14.6
si:ch211-160d14.6
chr5_-_43959972 0.20 ENSDART00000180517
si:ch211-204c21.1
si:ch211-204c21.1
chr10_+_25947946 0.20 ENSDART00000064393
ufm1
ubiquitin-fold modifier 1
chr11_+_11267829 0.20 ENSDART00000026814
ENSDART00000173346
ENSDART00000151926
ptp4a1
protein tyrosine phosphatase type IVA, member 1
chr3_+_24986145 0.20 ENSDART00000055428
cbx7a
chromobox homolog 7a
chr3_-_32859335 0.20 ENSDART00000158916
si:dkey-16l2.20
si:dkey-16l2.20
chr14_-_46117345 0.20 ENSDART00000172166
NDUFC1
si:ch211-235e9.6
chr3_-_38918697 0.20 ENSDART00000145630
si:dkey-106c17.2
si:dkey-106c17.2
chr15_-_37733238 0.20 ENSDART00000115178
si:dkey-42l23.7
si:dkey-42l23.7
chr12_-_19250854 0.20 ENSDART00000152844
cdc42ep1a
CDC42 effector protein (Rho GTPase binding) 1a
chr24_+_41940299 0.19 ENSDART00000022349
epb41l3a
erythrocyte membrane protein band 4.1-like 3a
chr2_+_7849890 0.19 ENSDART00000114241
si:ch211-38m6.6
si:ch211-38m6.6
chr25_-_3549321 0.18 ENSDART00000181214
ENSDART00000160600
hdhd5
haloacid dehalogenase like hydrolase domain containing 5
chr22_+_25049563 0.18 ENSDART00000078173
dzank1
double zinc ribbon and ankyrin repeat domains 1
chr15_-_31177324 0.18 ENSDART00000008854
wsb1
WD repeat and SOCS box containing 1
chr19_+_21919856 0.18 ENSDART00000187306
ENSDART00000138544
galr1a
galanin receptor 1a
chr9_+_38372216 0.18 ENSDART00000141895
plcd4b
phospholipase C, delta 4b
chr21_-_30415524 0.18 ENSDART00000101036
grpel2
GrpE-like 2, mitochondrial
chr9_-_21838045 0.18 ENSDART00000147471
acod1
aconitate decarboxylase 1
chr18_+_5137241 0.18 ENSDART00000159601
serpini1
serpin peptidase inhibitor, clade I (neuroserpin), member 1
chr23_-_437467 0.18 ENSDART00000192106
tspan2b
tetraspanin 2b
chr12_-_49154934 0.17 ENSDART00000153363
hmx3b
H6 family homeobox 3b
chr1_-_22735924 0.17 ENSDART00000134831
prom1b
prominin 1 b
chr1_-_52497834 0.17 ENSDART00000136469
ENSDART00000004233
acy3.2
aspartoacylase (aminocyclase) 3, tandem duplicate 2
chr16_+_49005321 0.17 ENSDART00000160919
CABZ01068499.1

chr10_+_1638876 0.17 ENSDART00000184484
ENSDART00000060946
ENSDART00000181251
sgsm1b
small G protein signaling modulator 1b
chr9_+_7030016 0.17 ENSDART00000148047
ENSDART00000148181
inpp4aa
inositol polyphosphate-4-phosphatase type I Aa
chr8_+_28695914 0.16 ENSDART00000033386
ocstamp
osteoclast stimulatory transmembrane protein
chr1_+_31113951 0.16 ENSDART00000129362
eef1a1b
eukaryotic translation elongation factor 1 alpha 1b
chr11_+_11267493 0.16 ENSDART00000148425
ptp4a1
protein tyrosine phosphatase type IVA, member 1
chr8_+_43053519 0.16 ENSDART00000147178
prnpa
prion protein a
chr4_-_77506362 0.16 ENSDART00000174387
ENSDART00000181181
CABZ01087415.1

chr25_+_13498188 0.15 ENSDART00000015710
snrkb
SNF related kinase b
chr8_+_4333914 0.15 ENSDART00000137528
myl2b
myosin, light chain 2b, regulatory, cardiac, slow
chr1_-_59139599 0.15 ENSDART00000152233
si:ch1073-110a20.3
si:ch1073-110a20.3
chr4_-_69189894 0.15 ENSDART00000169596
si:ch211-209j12.1
si:ch211-209j12.1
chr23_+_40460333 0.15 ENSDART00000184658
soga3b
SOGA family member 3b
chr20_+_7084154 0.15 ENSDART00000136448
ftr85
finTRIM family, member 85
chr17_+_21452258 0.15 ENSDART00000157098
pla2g4f.1
phospholipase A2, group IVF, tandem duplicate 1
chr18_+_31410652 0.15 ENSDART00000098504
def8
differentially expressed in FDCP 8 homolog (mouse)
chr12_+_33151246 0.15 ENSDART00000162681
rbfox3a
RNA binding fox-1 homolog 3a
chr5_+_9037650 0.15 ENSDART00000158226
si:ch211-155m12.1
si:ch211-155m12.1
chr14_+_36869273 0.15 ENSDART00000111674
F2RL3
si:ch211-132p1.2
chr5_+_40224938 0.14 ENSDART00000142897
si:dkey-193c22.2
si:dkey-193c22.2
chr1_-_40227166 0.14 ENSDART00000146680
si:ch211-113e8.3
si:ch211-113e8.3
chr17_+_15413412 0.14 ENSDART00000149871
cx40.8
connexin 40.8
chr23_-_28294763 0.14 ENSDART00000139537
znf385a
zinc finger protein 385A
chr8_-_38105053 0.14 ENSDART00000131546
adgra2
adhesion G protein-coupled receptor A2
chr2_-_21847935 0.14 ENSDART00000003940
rab2a
RAB2A, member RAS oncogene family
chr10_-_4316015 0.14 ENSDART00000109916
ENSDART00000180867
grin3a
glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
chr12_-_45669050 0.14 ENSDART00000124455
fbxl15
F-box and leucine-rich repeat protein 15

Network of associatons between targets according to the STRING database.

First level regulatory network of fosb+fosl2+si:ch211-153j24.3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0060546 negative regulation of necroptotic process(GO:0060546) negative regulation of necrotic cell death(GO:0060547)
0.2 0.7 GO:0090387 phagosome maturation involved in apoptotic cell clearance(GO:0090386) phagolysosome assembly involved in apoptotic cell clearance(GO:0090387)
0.2 0.8 GO:0035988 chondrocyte proliferation(GO:0035988)
0.1 0.4 GO:0034382 chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830) intermediate-density lipoprotein particle clearance(GO:0071831)
0.1 0.4 GO:0002432 granuloma formation(GO:0002432) chronic inflammatory response(GO:0002544) regulation of granuloma formation(GO:0002631) regulation of chronic inflammatory response(GO:0002676)
0.1 0.7 GO:0046638 neutrophil apoptotic process(GO:0001781) regulation of T-helper 1 type immune response(GO:0002825) positive regulation of T-helper 1 type immune response(GO:0002827) negative regulation of type 2 immune response(GO:0002829) inflammatory cell apoptotic process(GO:0006925) regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of phospholipase A2 activity(GO:0032429) interleukin-2 production(GO:0032623) regulation of interleukin-2 production(GO:0032663) positive regulation of interleukin-2 production(GO:0032743) myeloid cell apoptotic process(GO:0033028) regulation of neutrophil apoptotic process(GO:0033029) positive regulation of neutrophil apoptotic process(GO:0033031) regulation of myeloid cell apoptotic process(GO:0033032) positive regulation of myeloid cell apoptotic process(GO:0033034) T-helper 1 type immune response(GO:0042088) positive regulation of CD4-positive, alpha-beta T cell differentiation(GO:0043372) T-helper 1 cell differentiation(GO:0045063) positive regulation of T-helper cell differentiation(GO:0045624) regulation of T-helper 1 cell differentiation(GO:0045625) positive regulation of T-helper 1 cell differentiation(GO:0045627) regulation of T-helper 2 cell differentiation(GO:0045628) negative regulation of T-helper 2 cell differentiation(GO:0045629) positive regulation of fatty acid biosynthetic process(GO:0045723) positive regulation of alpha-beta T cell differentiation(GO:0046638) neutrophil clearance(GO:0097350) negative regulation of phospholipase A2 activity(GO:1900138) positive regulation of CD4-positive, alpha-beta T cell activation(GO:2000516) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.1 0.6 GO:0099612 protein localization to juxtaparanode region of axon(GO:0071205) protein localization to axon(GO:0099612)
0.1 1.5 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.1 0.5 GO:0070254 mucus secretion(GO:0070254)
0.1 0.7 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889)
0.1 0.1 GO:0022009 central nervous system vasculogenesis(GO:0022009)
0.1 0.8 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.1 0.5 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.1 0.2 GO:1900060 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) negative regulation of ceramide biosynthetic process(GO:1900060) regulation of membrane lipid metabolic process(GO:1905038) regulation of ceramide biosynthetic process(GO:2000303)
0.0 0.5 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.0 0.5 GO:0006450 regulation of translational fidelity(GO:0006450)
0.0 0.3 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.0 0.3 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 0.6 GO:0006603 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.0 0.7 GO:0046549 retinal cone cell development(GO:0046549)
0.0 1.3 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.0 0.2 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0 0.2 GO:2000391 neutrophil extravasation(GO:0072672) regulation of neutrophil extravasation(GO:2000389) positive regulation of neutrophil extravasation(GO:2000391)
0.0 0.7 GO:0001990 regulation of systemic arterial blood pressure by hormone(GO:0001990)
0.0 0.7 GO:0060285 cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285)
0.0 0.4 GO:0014034 neural crest cell fate commitment(GO:0014034) neural crest cell fate specification(GO:0014036)
0.0 1.0 GO:0032482 Rab protein signal transduction(GO:0032482)
0.0 4.3 GO:0002088 lens development in camera-type eye(GO:0002088)
0.0 0.1 GO:0019418 sulfide oxidation(GO:0019418) sulfide oxidation, using sulfide:quinone oxidoreductase(GO:0070221)
0.0 0.3 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.0 0.2 GO:0008343 adult feeding behavior(GO:0008343)
0.0 0.1 GO:0001778 plasma membrane repair(GO:0001778) monocyte activation(GO:0042117)
0.0 0.1 GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway(GO:0071881)
0.0 0.5 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0 0.2 GO:1903426 regulation of reactive oxygen species biosynthetic process(GO:1903426)
0.0 0.1 GO:0016038 absorption of visible light(GO:0016038)
0.0 0.7 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.0 0.3 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.0 0.2 GO:1904861 excitatory synapse assembly(GO:1904861)
0.0 0.3 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.1 GO:0006864 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
0.0 0.4 GO:0010257 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.2 GO:0031269 pseudopodium organization(GO:0031268) pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.0 1.4 GO:0014904 myotube cell development(GO:0014904) skeletal muscle fiber development(GO:0048741)
0.0 0.1 GO:1902093 positive regulation of sperm motility(GO:1902093)
0.0 0.1 GO:0001774 microglial cell activation(GO:0001774)
0.0 0.3 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.4 GO:0021884 forebrain neuron development(GO:0021884)
0.0 0.2 GO:0060217 hemangioblast cell differentiation(GO:0060217)
0.0 0.3 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.0 0.2 GO:0031641 regulation of myelination(GO:0031641)
0.0 0.2 GO:0015858 nucleoside transport(GO:0015858) nucleoside transmembrane transport(GO:1901642)
0.0 0.6 GO:0060840 artery development(GO:0060840)
0.0 0.3 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.0 0.3 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.2 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471)
0.0 0.2 GO:0032418 lysosome localization(GO:0032418)
0.0 0.3 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 0.2 GO:0033077 T cell differentiation in thymus(GO:0033077) thymocyte aggregation(GO:0071594)
0.0 0.3 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 0.2 GO:0051350 negative regulation of adenylate cyclase activity(GO:0007194) negative regulation of cyclic nucleotide metabolic process(GO:0030800) negative regulation of cyclic nucleotide biosynthetic process(GO:0030803) negative regulation of nucleotide biosynthetic process(GO:0030809) negative regulation of cAMP metabolic process(GO:0030815) negative regulation of cAMP biosynthetic process(GO:0030818) negative regulation of cyclase activity(GO:0031280) negative regulation of lyase activity(GO:0051350) negative regulation of purine nucleotide biosynthetic process(GO:1900372)
0.0 0.1 GO:0006543 glutamate biosynthetic process(GO:0006537) glutamine catabolic process(GO:0006543)
0.0 0.0 GO:0071918 urea transmembrane transport(GO:0071918)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.1 0.2 GO:0043218 compact myelin(GO:0043218) Schmidt-Lanterman incisure(GO:0043220)
0.1 1.4 GO:0005869 dynactin complex(GO:0005869)
0.1 0.7 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 0.6 GO:0033010 paranodal junction(GO:0033010)
0.1 1.3 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 0.2 GO:0035339 SPOTS complex(GO:0035339)
0.1 0.7 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.0 0.7 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.2 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.0 0.3 GO:0044232 organelle membrane contact site(GO:0044232)
0.0 0.7 GO:0030057 desmosome(GO:0030057)
0.0 0.1 GO:1990909 Wnt signalosome(GO:1990909)
0.0 0.3 GO:0014704 intercalated disc(GO:0014704)
0.0 0.4 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.2 GO:0071914 prominosome(GO:0071914)
0.0 0.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.7 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.1 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.1 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.0 0.1 GO:0032426 stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142) stereocilium tip(GO:0032426)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.1 0.4 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.1 1.0 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316)
0.1 0.7 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.1 0.4 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.1 0.7 GO:0070330 aromatase activity(GO:0070330)
0.1 0.4 GO:0005153 interleukin-8 receptor binding(GO:0005153)
0.1 0.3 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.1 0.7 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 0.3 GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity(GO:0004639)
0.1 1.6 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 4.6 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 0.7 GO:0043028 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)
0.1 0.3 GO:0019215 intermediate filament binding(GO:0019215)
0.0 0.5 GO:0004046 aminoacylase activity(GO:0004046)
0.0 0.5 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 0.6 GO:0004111 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.0 0.3 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0 0.1 GO:0070224 sulfide:quinone oxidoreductase activity(GO:0070224)
0.0 0.2 GO:0035252 UDP-xylosyltransferase activity(GO:0035252)
0.0 0.2 GO:0004966 galanin receptor activity(GO:0004966)
0.0 0.1 GO:0005502 11-cis retinal binding(GO:0005502)
0.0 0.1 GO:0008397 sterol 12-alpha-hydroxylase activity(GO:0008397)
0.0 0.2 GO:0008504 monoamine transmembrane transporter activity(GO:0008504)
0.0 0.2 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.0 0.1 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.6 GO:0042577 lipid phosphatase activity(GO:0042577)
0.0 0.1 GO:0004938 alpha2-adrenergic receptor activity(GO:0004938)
0.0 0.1 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.0 0.1 GO:0051185 coenzyme transporter activity(GO:0051185)
0.0 0.1 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
0.0 0.3 GO:0031682 G-protein gamma-subunit binding(GO:0031682)
0.0 0.2 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.1 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 0.1 GO:0003958 NADPH-hemoprotein reductase activity(GO:0003958)
0.0 0.3 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.9 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.6 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.1 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 0.1 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.0 1.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.3 GO:0004875 complement receptor activity(GO:0004875)
0.0 0.2 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.5 GO:0000049 tRNA binding(GO:0000049)
0.0 0.3 GO:0042162 telomeric DNA binding(GO:0042162)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 1.0 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.3 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.8 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.1 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 0.2 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.4 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.8 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.7 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.7 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.1 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 0.4 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.4 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 0.3 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.1 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0 0.1 REACTOME ADP SIGNALLING THROUGH P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.0 0.1 REACTOME OPSINS Genes involved in Opsins
0.0 0.2 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 0.6 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport