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PRJNA195909:zebrafish embryo and larva development

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Results for foxo3b+foxo6a+foxo6b

Z-value: 1.37

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Transcription factors associated with foxo3b+foxo6a+foxo6b

Gene Symbol Gene ID Gene Info
foxo6b
ENSDARG00000024619 forkhead box O6 b
foxo3b
ENSDARG00000042904 forkhead box O3b
foxo6a
ENSDARG00000100486 forkhead box O6 a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
foxo6bdr11_v1_chr19_+_15571290_15571290-0.844.7e-03Click!
foxo3bdr11_v1_chr20_-_32332736_32332736-0.761.7e-02Click!
foxo6adr11_v1_chr16_-_7362806_7362806-0.442.3e-01Click!

Activity profile of foxo3b+foxo6a+foxo6b motif

Sorted Z-values of foxo3b+foxo6a+foxo6b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr22_+_25753972 2.20 ENSDART00000188417
AL929192.2

chr23_+_28322986 2.14 ENSDART00000134710
birc5b
baculoviral IAP repeat containing 5b
chr15_+_38299385 2.01 ENSDART00000142403
si:dkey-24p1.6
si:dkey-24p1.6
chr15_+_38299563 1.87 ENSDART00000099375
si:dkey-24p1.6
si:dkey-24p1.6
chr5_-_17876709 1.78 ENSDART00000141978
si:dkey-112e17.1
si:dkey-112e17.1
chr4_-_12781182 1.76 ENSDART00000058020
helb
helicase (DNA) B
chr6_-_41138854 1.52 ENSDART00000128723
ENSDART00000151055
ENSDART00000132484
slc6a22.1
solute carrier family 6 member 22, tandem duplicate 1
chr10_-_25570647 1.46 ENSDART00000134215
grik1a
glutamate receptor, ionotropic, kainate 1a
chr7_+_69449814 1.46 ENSDART00000109644
ctdnep1b
CTD nuclear envelope phosphatase 1b
chr21_-_17037907 1.35 ENSDART00000101263
ube2g1b
ubiquitin-conjugating enzyme E2G 1b (UBC7 homolog, yeast)
chr5_-_62940851 1.18 ENSDART00000137052
specc1
sperm antigen with calponin homology and coiled-coil domains 1
chr5_+_29652513 1.17 ENSDART00000035400
tsc1a
TSC complex subunit 1a
chr16_-_44878245 1.12 ENSDART00000154391
ENSDART00000154925
ENSDART00000154697
arhgap33
Rho GTPase activating protein 33
chr12_-_48188928 1.11 ENSDART00000184384
pald1a
phosphatase domain containing, paladin 1a
chr5_-_25733745 1.11 ENSDART00000051566
zgc:101016
zgc:101016
chr22_-_10440688 1.10 ENSDART00000111962
nol8
nucleolar protein 8
chr25_-_36261836 1.10 ENSDART00000179411
dus2
dihydrouridine synthase 2
chr1_-_45616242 1.09 ENSDART00000150066
atf7ip
activating transcription factor 7 interacting protein
chr24_+_5829265 1.09 ENSDART00000155242
si:ch211-157j23.5
si:ch211-157j23.5
chr5_-_12031174 1.08 ENSDART00000159896
castor1
cytosolic arginine sensor for mTORC1 subunit 1
chr22_-_5958066 1.07 ENSDART00000145821
si:rp71-36a1.3
si:rp71-36a1.3
chr11_-_7147540 1.06 ENSDART00000143942
bmp7a
bone morphogenetic protein 7a
chr19_-_7441686 1.05 ENSDART00000168194
gabpb2a
GA binding protein transcription factor, beta subunit 2a
chr6_-_57476465 1.04 ENSDART00000128065
ddx27
DEAD (Asp-Glu-Ala-Asp) box polypeptide 27
chr7_+_40094081 1.04 ENSDART00000186054
si:ch73-174h16.4
si:ch73-174h16.4
chr5_-_68795063 1.04 ENSDART00000016307
her1
hairy-related 1
chr2_-_37478418 1.04 ENSDART00000146103
dapk3
death-associated protein kinase 3
chr1_-_45616470 1.03 ENSDART00000150165
atf7ip
activating transcription factor 7 interacting protein
chr14_-_6402769 1.02 ENSDART00000121552
slc44a1b
solute carrier family 44 (choline transporter), member 1b
chr2_-_56757069 1.02 ENSDART00000164461
hmha1a
histocompatibility (minor) HA-1 a
chr25_-_8160030 1.02 ENSDART00000067159
tph1a
tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) a
chr2_-_43850897 1.01 ENSDART00000005449
zeb1a
zinc finger E-box binding homeobox 1a
chr20_-_24165509 1.01 ENSDART00000124919
map3k7
mitogen-activated protein kinase kinase kinase 7
chr11_+_14343445 1.00 ENSDART00000171347
ENSDART00000170547
si:ch211-262i1.6
si:ch211-262i1.6
chr7_-_20241346 0.99 ENSDART00000173619
ENSDART00000127699
si:ch73-335l21.4
si:ch73-335l21.4
chr21_-_3606539 0.98 ENSDART00000062418
dym
dymeclin
chr16_+_26747766 0.97 ENSDART00000183257
rad54b
RAD54 homolog B (S. cerevisiae)
chr5_+_56119975 0.95 ENSDART00000083137
mrm1
mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
chr7_-_32021853 0.92 ENSDART00000134521
kif18a
kinesin family member 18A
chr8_-_53044300 0.91 ENSDART00000191653
nr6a1a
nuclear receptor subfamily 6, group A, member 1a
chr21_-_28640316 0.91 ENSDART00000128237
nrg2a
neuregulin 2a
chr5_+_29652198 0.91 ENSDART00000184083
tsc1a
TSC complex subunit 1a
chr10_-_7472323 0.88 ENSDART00000163702
ENSDART00000167054
ENSDART00000167706
nrg1
neuregulin 1
chr7_+_30240791 0.88 ENSDART00000109243
sema4bb
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Bb
chr23_-_36670369 0.87 ENSDART00000006881
zbtb39
zinc finger and BTB domain containing 39
chr24_-_25030173 0.86 ENSDART00000126395
ENSDART00000019350
nup58
nucleoporin 58
chr25_+_4855549 0.86 ENSDART00000163839
ap4e1
adaptor-related protein complex 4, epsilon 1 subunit
chr17_+_24111392 0.86 ENSDART00000180123
ENSDART00000182787
ENSDART00000189752
ENSDART00000184940
ENSDART00000185363
ENSDART00000064067
ehbp1
EH domain binding protein 1
chr2_-_38080075 0.85 ENSDART00000056544
tox4a
TOX high mobility group box family member 4 a
chr9_+_27720428 0.85 ENSDART00000112415
lcmt2
leucine carboxyl methyltransferase 2
chr24_+_32411753 0.85 ENSDART00000058530
neurod6a
neuronal differentiation 6a
chr12_+_18970790 0.84 ENSDART00000153279
ENSDART00000153235
ENSDART00000078494
l3mbtl2
l(3)mbt-like 2 (Drosophila)
chr21_+_17301790 0.84 ENSDART00000145057
tsc1b
TSC complex subunit 1b
chr1_+_10018466 0.83 ENSDART00000113551
trim2b
tripartite motif containing 2b
chr6_-_18531760 0.80 ENSDART00000167167
utp6
UTP6, small subunit (SSU) processome component, homolog (yeast)
chr19_-_7441948 0.80 ENSDART00000003544
gabpb2a
GA binding protein transcription factor, beta subunit 2a
chr17_-_10059557 0.78 ENSDART00000092209
ENSDART00000161243
baz1a
bromodomain adjacent to zinc finger domain, 1A
chr16_+_53519048 0.78 ENSDART00000124691
smpd5
sphingomyelin phosphodiesterase 5
chr13_-_13030851 0.77 ENSDART00000009499
nsd2
nuclear receptor binding SET domain protein 2
chr9_+_426392 0.75 ENSDART00000172515
bzw1b
basic leucine zipper and W2 domains 1b
chr14_+_45350008 0.74 ENSDART00000025749
ttc9c
tetratricopeptide repeat domain 9C
chr20_+_41801913 0.74 ENSDART00000139805
mcm9
minichromosome maintenance 9 homologous recombination repair factor
chr7_+_32021669 0.73 ENSDART00000173976
mettl15
methyltransferase like 15
chr8_-_52091696 0.71 ENSDART00000108923
vps13a
vacuolar protein sorting 13 homolog A (S. cerevisiae)
chr16_-_29405009 0.69 ENSDART00000149289
tlr18
toll-like receptor 18
chr2_+_22409249 0.69 ENSDART00000182915
zgc:56628
zgc:56628
chr17_-_5610514 0.68 ENSDART00000004043
enpp4
ectonucleotide pyrophosphatase/phosphodiesterase 4
chr15_-_33304133 0.68 ENSDART00000186092
nbeab
neurobeachin b
chr5_-_323712 0.67 ENSDART00000188793
HOOK3
hook microtubule tethering protein 3
chr17_+_51746830 0.66 ENSDART00000184230
odc1
ornithine decarboxylase 1
chr5_+_28433215 0.66 ENSDART00000165072
ENSDART00000168005
nsmfb
NMDA receptor synaptonuclear signaling and neuronal migration factor b
chr14_-_45551572 0.66 ENSDART00000111410
ganab
glucosidase, alpha; neutral AB
chr5_-_26118855 0.66 ENSDART00000009028
ela3l
elastase 3 like
chr9_-_12574473 0.65 ENSDART00000191372
ENSDART00000193667
igf2bp2a
insulin-like growth factor 2 mRNA binding protein 2a
chr5_-_30145939 0.64 ENSDART00000086795
zbtb44
zinc finger and BTB domain containing 44
chr20_-_33583779 0.64 ENSDART00000097823
rock2b
rho-associated, coiled-coil containing protein kinase 2b
chr7_+_26006819 0.64 ENSDART00000112908
pelp1
proline, glutamate and leucine rich protein 1
chr21_-_13123176 0.64 ENSDART00000144866
ENSDART00000024616
fam219aa
family with sequence similarity 219, member Aa
chr9_-_27410597 0.63 ENSDART00000135652
ENSDART00000042297
kdelc1
KDEL (Lys-Asp-Glu-Leu) containing 1
chr22_+_18319666 0.63 ENSDART00000033103
gatad2ab
GATA zinc finger domain containing 2Ab
chr18_-_44527124 0.62 ENSDART00000189471
aplp2
amyloid beta (A4) precursor-like protein 2
chr20_+_25911342 0.62 ENSDART00000146004
ttbk2b
tau tubulin kinase 2b
chr11_-_23697217 0.61 ENSDART00000124810
pik3c2b
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
chr8_-_16464453 0.60 ENSDART00000098691
rnf11b
ring finger protein 11b
chr11_-_14924138 0.59 ENSDART00000168348
si:dkey-6d5.1
si:dkey-6d5.1
chr11_-_21404044 0.58 ENSDART00000080116
ikbke
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr25_-_35127617 0.58 ENSDART00000125128
hist1h2a4
histone cluster 1 H2A family member 4
chr17_+_28670132 0.58 ENSDART00000076344
ENSDART00000164981
ENSDART00000182851
hectd1
HECT domain containing 1
chr7_+_32021982 0.57 ENSDART00000173848
mettl15
methyltransferase like 15
chr25_+_28158352 0.57 ENSDART00000151854
cadps2
Ca++-dependent secretion activator 2
chr9_-_3149896 0.56 ENSDART00000020861
pdk1
pyruvate dehydrogenase kinase, isozyme 1
chr5_+_25733774 0.56 ENSDART00000137088
ENSDART00000098467
abhd17b
abhydrolase domain containing 17B
chr8_+_18010978 0.55 ENSDART00000039887
ENSDART00000144532
ssbp3b
single stranded DNA binding protein 3b
chr18_+_21113216 0.53 ENSDART00000060191
kmt5b
lysine methyltransferase 5B
chr22_+_7480465 0.53 ENSDART00000034545
CELA1 (1 of many)
zgc:92745
chr3_-_48716422 0.52 ENSDART00000164979
si:ch211-114m9.1
si:ch211-114m9.1
chr14_-_10617127 0.52 ENSDART00000154299
si:dkey-92i17.2
si:dkey-92i17.2
chr12_+_17603528 0.51 ENSDART00000111565
pms2
PMS1 homolog 2, mismatch repair system component
chr19_-_19599372 0.51 ENSDART00000160002
ENSDART00000171664
tax1bp1a
Tax1 (human T-cell leukemia virus type I) binding protein 1a
chr5_+_1933131 0.50 ENSDART00000061693
si:ch73-55i23.1
si:ch73-55i23.1
chr24_+_19414561 0.50 ENSDART00000193157
sulf1
sulfatase 1
chr15_-_8177919 0.49 ENSDART00000101463
bach1a
BTB and CNC homology 1, basic leucine zipper transcription factor 1 a
chr9_+_24088062 0.48 ENSDART00000126198
lrrfip1a
leucine rich repeat (in FLII) interacting protein 1a
chr12_+_11352630 0.48 ENSDART00000129495
si:rp71-19m20.1
si:rp71-19m20.1
chr18_+_41527877 0.46 ENSDART00000146972
selenot1b
selenoprotein T, 1b
chr13_+_48358467 0.45 ENSDART00000171080
ENSDART00000162531
msh6
mutS homolog 6 (E. coli)
chr8_-_36125849 0.45 ENSDART00000159581
CT583723.1

chr6_+_18531932 0.45 ENSDART00000165271
suz12b
SUZ12 polycomb repressive complex 2b subunit
chr22_+_18319230 0.45 ENSDART00000184747
ENSDART00000184649
gatad2ab
GATA zinc finger domain containing 2Ab
chr20_+_33994580 0.44 ENSDART00000061729
si:dkey-97o5.1
si:dkey-97o5.1
chr3_+_52684556 0.43 ENSDART00000139037
pgls
6-phosphogluconolactonase
chr19_+_19600297 0.43 ENSDART00000160134
ENSDART00000183493
hibadha
3-hydroxyisobutyrate dehydrogenase a
chr3_+_60828813 0.42 ENSDART00000128260
CABZ01087514.1

chr16_-_31351419 0.42 ENSDART00000178298
ENSDART00000018091
mroh1
maestro heat-like repeat family member 1
chr23_+_36308428 0.42 ENSDART00000134607
hnrnpa1b
heterogeneous nuclear ribonucleoprotein A1b
chr19_-_30447611 0.41 ENSDART00000073705
ENSDART00000048977
ENSDART00000191237
abcf1
ATP-binding cassette, sub-family F (GCN20), member 1
chr16_+_46410520 0.41 ENSDART00000131072
rpz2
rapunzel 2
chr22_+_2524615 0.41 ENSDART00000134277
znf1003
zinc finger protein 1003
chr20_+_22067337 0.41 ENSDART00000152636
clocka
clock circadian regulator a
chr16_+_29586004 0.40 ENSDART00000149520
mcl1b
MCL1, BCL2 family apoptosis regulator b
chr16_-_25400257 0.39 ENSDART00000040756
zgc:136493
zgc:136493
chr6_+_55819038 0.39 ENSDART00000108786
si:ch211-81n22.1
si:ch211-81n22.1
chr11_+_41560792 0.39 ENSDART00000127292
kcnab2a
potassium voltage-gated channel, shaker-related subfamily, beta member 2 a
chr3_+_9588705 0.38 ENSDART00000172543
ENSDART00000104875
trap1
TNF receptor-associated protein 1
chr13_-_25842074 0.37 ENSDART00000015154
papolg
poly(A) polymerase gamma
chr18_+_48953963 0.36 ENSDART00000158104
SHKBP1
SH3KBP1 binding protein 1
chr2_-_7131657 0.36 ENSDART00000175565
ENSDART00000092116
extl2
exostosin-like glycosyltransferase 2
chr17_-_50472864 0.36 ENSDART00000161066
ENSDART00000156963
si:ch211-235i11.3
si:ch211-235i11.3
chr7_-_50764714 0.35 ENSDART00000110283
iqgap1
IQ motif containing GTPase activating protein 1
chr8_-_18010735 0.35 ENSDART00000125014
acot11b
acyl-CoA thioesterase 11b
chr8_-_8426504 0.35 ENSDART00000191686
ENSDART00000181523
cdk16
cyclin-dependent kinase 16
chr20_-_7069612 0.34 ENSDART00000040793
sirt5
sirtuin 5
chr18_-_44526940 0.33 ENSDART00000077125
aplp2
amyloid beta (A4) precursor-like protein 2
chr4_-_77377596 0.32 ENSDART00000186068
slco1e1
solute carrier organic anion transporter family, member 1E1
chr10_-_57270 0.31 ENSDART00000058411
hlcs
holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
chr19_-_13286722 0.30 ENSDART00000168296
ENSDART00000158330
zfpm2b
zinc finger protein, FOG family member 2b
chr22_+_7462997 0.30 ENSDART00000106082
zgc:112368
zgc:112368
chr24_+_9612410 0.30 ENSDART00000142460
ENSDART00000110629
nphp3
nephronophthisis 3
chr11_-_22303678 0.29 ENSDART00000159527
ENSDART00000159681
tfeb
transcription factor EB
chr14_+_23158021 0.29 ENSDART00000084664
enox2
ecto-NOX disulfide-thiol exchanger 2
chr14_-_4682114 0.28 ENSDART00000014454
gabra4
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4
chr5_-_51998708 0.28 ENSDART00000097194
serinc5
serine incorporator 5
chr1_+_19708508 0.28 ENSDART00000054581
ENSDART00000131206
march1
membrane-associated ring finger (C3HC4) 1
chr23_-_12158685 0.27 ENSDART00000135035
fam217b
family with sequence similarity 217, member B
chr7_-_19966406 0.27 ENSDART00000010932
snx15
sorting nexin 15
chr16_-_21692024 0.27 ENSDART00000123597
si:ch211-154o6.2
si:ch211-154o6.2
chr24_+_19415124 0.26 ENSDART00000186931
sulf1
sulfatase 1
chr22_+_2533514 0.26 ENSDART00000147967
si:ch73-92e7.4
si:ch73-92e7.4
chr22_-_17499513 0.26 ENSDART00000105460
si:ch211-197g15.6
si:ch211-197g15.6
chr17_-_50454957 0.25 ENSDART00000171616
ENSDART00000075195
si:ch211-235i11.7
si:ch211-235i11.7
chr17_-_50436199 0.24 ENSDART00000156494
si:ch211-235i11.6
si:ch211-235i11.6
chr22_-_21676364 0.23 ENSDART00000183668
tle2b
transducin like enhancer of split 2b
chr1_-_11616142 0.23 ENSDART00000131668
si:dkey-26i13.5
si:dkey-26i13.5
chr2_+_23130389 0.23 ENSDART00000142834
si:dkey-218h11.6
si:dkey-218h11.6
chr12_+_28799988 0.22 ENSDART00000022724
pnpo
pyridoxamine 5'-phosphate oxidase
chr12_+_46582168 0.21 ENSDART00000189402
ush1gb
Usher syndrome 1Gb (autosomal recessive)
chr14_-_46238186 0.21 ENSDART00000173245
si:ch211-113d11.6
si:ch211-113d11.6
chr1_+_8314826 0.21 ENSDART00000160440
cacna1hb
calcium channel, voltage-dependent, T type, alpha 1H subunit b
chr22_+_10440991 0.19 ENSDART00000064805
cenpp
centromere protein P
chr7_-_21928826 0.19 ENSDART00000088043
si:dkey-85k7.11
si:dkey-85k7.11
chr15_-_19334448 0.18 ENSDART00000062576
thyn1
thymocyte nuclear protein 1
chr2_-_38125657 0.17 ENSDART00000143433
cbln12
cerebellin 12
chr6_+_10077756 0.17 ENSDART00000150982
htr2ab
5-hydroxytryptamine (serotonin) receptor 2A, genome duplicate b
chr4_+_20536120 0.17 ENSDART00000125685
zmp:0000000650
zmp:0000000650
chr23_+_4777612 0.16 ENSDART00000135933
vgll4a
vestigial-like family member 4a
chr24_+_14451404 0.16 ENSDART00000123674
ENSDART00000066720
prdm14
PR domain containing 14
chr7_+_4971938 0.16 ENSDART00000172889
ENSDART00000145389
si:dkey-81n2.2
si:dkey-81n2.2
chr13_-_31377299 0.15 ENSDART00000026692
ubtd1a
ubiquitin domain containing 1a
chr6_-_51386656 0.15 ENSDART00000154732
ENSDART00000177990
ENSDART00000184928
ENSDART00000180197
ptprt
protein tyrosine phosphatase, receptor type, t
chr15_-_8191992 0.15 ENSDART00000155381
ENSDART00000190714
bach1a
BTB and CNC homology 1, basic leucine zipper transcription factor 1 a
chr1_-_11606903 0.14 ENSDART00000136093
si:dkey-26i13.6
si:dkey-26i13.6
chr18_-_3103827 0.13 ENSDART00000165048
aamdc
adipogenesis associated, Mth938 domain containing
chr8_+_47897734 0.13 ENSDART00000140266
mfn2
mitofusin 2
chr21_-_37973081 0.13 ENSDART00000136569
ripply1
ripply transcriptional repressor 1
chr15_+_2534740 0.12 ENSDART00000138469
cux1b
cut-like homeobox 1b
chr2_+_44571200 0.12 ENSDART00000098132
klhl24a
kelch-like family member 24a
chr1_+_6646529 0.12 ENSDART00000144641
ENSDART00000103701
ENSDART00000138919
ube2f
ubiquitin-conjugating enzyme E2F (putative)
chr3_+_52078798 0.12 ENSDART00000156882
si:dkey-88e12.3
si:dkey-88e12.3
chr24_+_32472155 0.11 ENSDART00000098859
neurod6a
neuronal differentiation 6a
chr1_+_42874410 0.11 ENSDART00000153506
ctnna2
catenin (cadherin-associated protein), alpha 2
chr23_-_912817 0.11 ENSDART00000192851
rhoac
ras homolog gene family, member Ac
chr1_-_11616295 0.10 ENSDART00000188891
si:dkey-26i13.5
si:dkey-26i13.5
chr15_-_31357634 0.10 ENSDART00000127485
or111-2
odorant receptor, family D, subfamily 111, member 2
chr1_-_11607062 0.09 ENSDART00000158253
si:dkey-26i13.6
si:dkey-26i13.6
chr22_-_34995333 0.09 ENSDART00000110900
kcnip2
Kv channel interacting protein 2
chr3_-_31078348 0.08 ENSDART00000055360
elob
elongin B
chr25_-_35153985 0.08 ENSDART00000154851
zgc:153405
zgc:153405
chr20_+_45853154 0.08 ENSDART00000181109
AL929237.4

chr6_+_3864040 0.08 ENSDART00000013743
gorasp2
golgi reassembly stacking protein 2
chr10_-_36244864 0.07 ENSDART00000123748
or109-1
odorant receptor, family D, subfamily 109, member 1
chr21_+_5580948 0.06 ENSDART00000160373
ly6m7
lymphocyte antigen 6 family member M7
chr4_+_38547203 0.06 ENSDART00000171349
si:ch211-209n20.1
si:ch211-209n20.1
chr19_+_3840955 0.06 ENSDART00000172305
lsm10
LSM10, U7 small nuclear RNA associated
chr7_+_61906903 0.06 ENSDART00000108540
tdrd7b
tudor domain containing 7 b
chr2_-_24907741 0.05 ENSDART00000155013
si:dkey-149i17.11
si:dkey-149i17.11
chr22_-_23590069 0.05 ENSDART00000172067
f13b
coagulation factor XIII, B polypeptide
chr15_-_46736432 0.04 ENSDART00000124567
ilkap
integrin-linked kinase-associated serine/threonine phosphatase
chr20_+_13956106 0.03 ENSDART00000152826
si:dkey-249p7.4
si:dkey-249p7.4
chr15_+_22014029 0.02 ENSDART00000079504
ankk1
ankyrin repeat and kinase domain containing 1
chr2_+_10134345 0.02 ENSDART00000100725
ahsg2
alpha-2-HS-glycoprotein 2

Network of associatons between targets according to the STRING database.

First level regulatory network of foxo3b+foxo6a+foxo6b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:0000212 meiotic spindle organization(GO:0000212)
0.4 1.8 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.3 0.9 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171) Schwann cell migration(GO:0036135) cardiac neuron differentiation(GO:0060945) cardiac neuron development(GO:0060959)
0.3 1.5 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866) positive regulation of triglyceride biosynthetic process(GO:0010867)
0.3 0.9 GO:0031590 wybutosine metabolic process(GO:0031590) wybutosine biosynthetic process(GO:0031591)
0.3 0.8 GO:0097676 histone H3-K36 dimethylation(GO:0097676)
0.2 0.9 GO:0003222 ventricular trabecula myocardium morphogenesis(GO:0003222)
0.2 2.9 GO:0046627 negative regulation of insulin receptor signaling pathway(GO:0046627) negative regulation of cellular response to insulin stimulus(GO:1900077)
0.2 1.0 GO:0070587 regulation of cell-cell adhesion involved in gastrulation(GO:0070587)
0.2 0.5 GO:0034773 histone H4-K20 methylation(GO:0034770) histone H4-K20 trimethylation(GO:0034773) regulation of isotype switching(GO:0045191) positive regulation of isotype switching(GO:0045830)
0.2 1.0 GO:0042427 serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.2 2.1 GO:0090308 methylation-dependent chromatin silencing(GO:0006346) positive regulation of chromatin silencing(GO:0031937) regulation of methylation-dependent chromatin silencing(GO:0090308) positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.2 0.5 GO:0006290 somatic diversification of immune receptors via somatic mutation(GO:0002566) pyrimidine dimer repair(GO:0006290) somatic hypermutation of immunoglobulin genes(GO:0016446)
0.1 0.5 GO:0099563 modification of synaptic structure(GO:0099563)
0.1 1.3 GO:0070475 rRNA base methylation(GO:0070475)
0.1 0.7 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.1 0.8 GO:2000290 smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021910) regulation of myotome development(GO:2000290)
0.1 0.9 GO:0042664 locus ceruleus development(GO:0021703) negative regulation of endodermal cell fate specification(GO:0042664)
0.1 1.2 GO:0060325 face morphogenesis(GO:0060325)
0.1 0.8 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.1 0.7 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
0.1 0.2 GO:0042823 water-soluble vitamin biosynthetic process(GO:0042364) pyridoxal phosphate metabolic process(GO:0042822) pyridoxal phosphate biosynthetic process(GO:0042823)
0.1 1.1 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.1 0.3 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.1 0.7 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.1 0.3 GO:0007624 ultradian rhythm(GO:0007624)
0.0 0.6 GO:1990504 dense core granule exocytosis(GO:1990504)
0.0 0.4 GO:0098900 regulation of action potential(GO:0098900)
0.0 1.2 GO:0001757 somite specification(GO:0001757)
0.0 0.6 GO:0098734 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.0 0.2 GO:0034969 histone arginine methylation(GO:0034969)
0.0 0.3 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.4 GO:0006098 pentose-phosphate shunt(GO:0006098)
0.0 0.1 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.0 0.2 GO:0031055 chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0 0.6 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0 0.6 GO:1901888 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287) regulation of cell junction assembly(GO:1901888)
0.0 0.2 GO:0006574 valine catabolic process(GO:0006574)
0.0 0.1 GO:0051823 regulation of synapse structural plasticity(GO:0051823)
0.0 0.4 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.0 0.7 GO:0032474 otolith morphogenesis(GO:0032474)
0.0 0.8 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 0.2 GO:0050957 equilibrioception(GO:0050957)
0.0 0.5 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.0 0.5 GO:0006298 mismatch repair(GO:0006298)
0.0 1.0 GO:0007131 reciprocal meiotic recombination(GO:0007131)
0.0 0.3 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
0.0 0.6 GO:0051028 mRNA transport(GO:0051028)
0.0 0.7 GO:0032392 DNA geometric change(GO:0032392) DNA duplex unwinding(GO:0032508)
0.0 0.1 GO:0048660 regulation of smooth muscle cell proliferation(GO:0048660) negative regulation of smooth muscle cell proliferation(GO:0048662)
0.0 1.0 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.0 0.1 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.0 0.5 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 0.6 GO:0070534 protein K63-linked ubiquitination(GO:0070534)
0.0 0.3 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.0 0.9 GO:1902668 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.0 0.6 GO:0010906 regulation of glucose metabolic process(GO:0010906)
0.0 1.5 GO:0035249 synaptic transmission, glutamatergic(GO:0035249)
0.0 1.1 GO:0006400 tRNA modification(GO:0006400)
0.0 2.0 GO:0000209 protein polyubiquitination(GO:0000209)
0.0 0.9 GO:0030917 midbrain-hindbrain boundary development(GO:0030917)
0.0 0.2 GO:0071679 commissural neuron axon guidance(GO:0071679)
0.0 0.4 GO:0006378 mRNA polyadenylation(GO:0006378) RNA polyadenylation(GO:0043631)
0.0 1.1 GO:0034504 protein localization to nucleus(GO:0034504)
0.0 0.2 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.0 0.7 GO:0002224 toll-like receptor signaling pathway(GO:0002224)
0.0 0.3 GO:0051932 synaptic transmission, GABAergic(GO:0051932)
0.0 0.9 GO:0006913 nucleocytoplasmic transport(GO:0006913) nuclear transport(GO:0051169)
0.0 0.3 GO:0042181 ketone biosynthetic process(GO:0042181)
0.0 1.1 GO:0007030 Golgi organization(GO:0007030)
0.0 0.4 GO:0009648 photoperiodism(GO:0009648)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.9 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.3 1.5 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.2 0.9 GO:0061673 mitotic spindle astral microtubule(GO:0061673)
0.2 0.9 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.2 0.5 GO:0032301 MutSalpha complex(GO:0032301)
0.1 1.1 GO:0061700 GATOR2 complex(GO:0061700)
0.1 0.8 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.1 0.4 GO:1990513 CLOCK-BMAL transcription complex(GO:1990513)
0.1 0.5 GO:0032300 mismatch repair complex(GO:0032300)
0.1 1.1 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 2.1 GO:0005876 spindle microtubule(GO:0005876)
0.0 2.0 GO:0031941 filamentous actin(GO:0031941)
0.0 0.7 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.7 GO:0042555 MCM complex(GO:0042555)
0.0 0.5 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.4 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.9 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.0 0.8 GO:0005758 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.0 0.6 GO:0035869 ciliary transition zone(GO:0035869)
0.0 0.9 GO:0005643 nuclear pore(GO:0005643)
0.0 0.1 GO:0030891 VCB complex(GO:0030891)
0.0 0.6 GO:0098978 glutamatergic synapse(GO:0098978)
0.0 3.9 GO:0005730 nucleolus(GO:0005730)
0.0 0.6 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0016434 rRNA (cytosine) methyltransferase activity(GO:0016434)
0.4 1.1 GO:0034618 arginine binding(GO:0034618)
0.2 1.0 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.2 1.1 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.2 0.5 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.2 2.1 GO:0043028 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)
0.2 1.0 GO:0015616 DNA translocase activity(GO:0015616)
0.2 1.8 GO:0043142 single-stranded DNA-dependent ATP-dependent DNA helicase activity(GO:0017116) single-stranded DNA-dependent ATPase activity(GO:0043142)
0.2 0.5 GO:0032405 guanine/thymine mispair binding(GO:0032137) single base insertion or deletion binding(GO:0032138) single thymine insertion binding(GO:0032143) oxidized DNA binding(GO:0032356) oxidized purine DNA binding(GO:0032357) mismatch repair complex binding(GO:0032404) MutLalpha complex binding(GO:0032405)
0.1 0.4 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.1 1.5 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.1 0.3 GO:0000035 acyl binding(GO:0000035)
0.1 0.9 GO:0070700 BMP receptor binding(GO:0070700)
0.1 0.4 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.1 0.3 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.1 0.6 GO:0072518 Rho-dependent protein serine/threonine kinase activity(GO:0072518)
0.1 0.9 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.1 0.7 GO:0004586 ornithine decarboxylase activity(GO:0004586)
0.1 0.6 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.1 0.4 GO:0070888 E-box binding(GO:0070888)
0.1 0.8 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 1.7 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.1 0.5 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.1 0.4 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.0 0.8 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 0.5 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.7 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.0 0.8 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 1.0 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.2 GO:0008442 3-hydroxyisobutyrate dehydrogenase activity(GO:0008442)
0.0 0.9 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.2 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.7 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.8 GO:0030515 snoRNA binding(GO:0030515)
0.0 0.5 GO:0030983 mismatched DNA binding(GO:0030983)
0.0 0.6 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.2 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.0 0.9 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.6 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 1.4 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 1.8 GO:0008173 RNA methyltransferase activity(GO:0008173)
0.0 0.8 GO:0035064 methylated histone binding(GO:0035064)
0.0 1.4 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.4 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.0 0.1 GO:0061650 ubiquitin-like protein conjugating enzyme activity(GO:0061650)
0.0 0.9 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 1.0 GO:0003724 RNA helicase activity(GO:0003724)
0.0 1.1 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 0.9 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.4 PID NECTIN PATHWAY Nectin adhesion pathway
0.0 0.6 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.0 0.6 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.7 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.1 0.9 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 1.0 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.1 0.6 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.0 0.6 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.7 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.9 REACTOME KINESINS Genes involved in Kinesins
0.0 0.7 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.4 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.6 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.3 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.9 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis