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PRJNA195909:zebrafish embryo and larva development

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Results for foxo4

Z-value: 1.91

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Transcription factors associated with foxo4

Gene Symbol Gene ID Gene Info
foxo4
ENSDARG00000055792 forkhead box O4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
foxo4dr11_v1_chr14_+_30910114_309101140.472.0e-01Click!

Activity profile of foxo4 motif

Sorted Z-values of foxo4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr13_-_33207367 4.03 ENSDART00000146138
ENSDART00000109667
ENSDART00000182741
trip11
thyroid hormone receptor interactor 11
chr14_+_15155684 3.97 ENSDART00000167966
zgc:158852
zgc:158852
chr15_+_19990068 3.71 ENSDART00000154033
ENSDART00000054428
zgc:112083
zgc:112083
chr5_-_33236637 3.68 ENSDART00000085512
ENSDART00000144694
kank1b
KN motif and ankyrin repeat domains 1b
chr22_-_28777557 3.04 ENSDART00000135214
ENSDART00000131761
ENSDART00000005112
si:dkeyp-34c12.1
si:dkeyp-34c12.1
chr10_+_33744098 2.87 ENSDART00000147775
rxfp2a
relaxin/insulin-like family peptide receptor 2a
chr16_+_31511739 2.80 ENSDART00000049420
ndrg1b
N-myc downstream regulated 1b
chr22_+_38276024 2.79 ENSDART00000143792
rcor3
REST corepressor 3
chr6_+_38626926 2.72 ENSDART00000190339
atp10a
ATPase phospholipid transporting 10A
chr8_+_37749263 2.61 ENSDART00000108556
ENSDART00000147942
npm2a
nucleophosmin/nucleoplasmin, 2a
chr21_+_20386865 2.58 ENSDART00000144366
si:dkey-30k6.5
si:dkey-30k6.5
chr20_-_52928541 2.57 ENSDART00000162812
fdft1
farnesyl-diphosphate farnesyltransferase 1
chr7_+_46019780 2.53 ENSDART00000163991
ccne1
cyclin E1
chr14_+_35424539 2.45 ENSDART00000171809
ENSDART00000162185
sytl4
synaptotagmin-like 4
chr11_+_11120532 2.41 ENSDART00000026135
ENSDART00000189872
ly75
lymphocyte antigen 75
chr2_-_26720854 2.39 ENSDART00000148110
si:dkey-181m9.8
si:dkey-181m9.8
chr23_-_1571682 2.33 ENSDART00000013635
fbxo30b
F-box protein 30b
chr17_+_14965570 2.32 ENSDART00000066604
gpr137c
G protein-coupled receptor 137c
chr19_+_31585341 2.29 ENSDART00000052185
gmnn
geminin, DNA replication inhibitor
chr1_-_9277986 2.28 ENSDART00000146065
ENSDART00000114876
ENSDART00000132812
ubn1
ubinuclein 1
chr17_+_44030692 2.26 ENSDART00000049503
peli2
pellino E3 ubiquitin protein ligase family member 2
chr16_-_13613475 2.25 ENSDART00000139102
dbpb
D site albumin promoter binding protein b
chr10_+_32050906 2.24 ENSDART00000137373
si:ch211-266i6.3
si:ch211-266i6.3
chr17_+_33158350 2.22 ENSDART00000104476
snx9a
sorting nexin 9a
chr19_-_868187 2.22 ENSDART00000186626
eomesa
eomesodermin homolog a
chr3_-_15679107 2.17 ENSDART00000080441
zgc:66443
zgc:66443
chr2_-_4787566 2.16 ENSDART00000160663
ENSDART00000157808
tnk2b
tyrosine kinase, non-receptor, 2b
chr8_+_16990120 2.12 ENSDART00000018934
pde4d
phosphodiesterase 4D, cAMP-specific
chr17_-_7218481 2.10 ENSDART00000181967
SAMD5
sterile alpha motif domain containing 5
chr7_+_24528866 2.08 ENSDART00000180552
si:dkeyp-75h12.2
si:dkeyp-75h12.2
chr16_-_26820634 2.02 ENSDART00000111156
pdp1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr16_-_41714988 1.97 ENSDART00000138798
cep85
centrosomal protein 85
chr1_+_53321878 1.95 ENSDART00000143909
tbc1d9
TBC1 domain family, member 9 (with GRAM domain)
chr14_+_41406321 1.95 ENSDART00000111480
bcorl1
BCL6 corepressor-like 1
chr5_+_44846434 1.95 ENSDART00000145299
ENSDART00000136521
kank1a
KN motif and ankyrin repeat domains 1a
chr8_+_7778770 1.94 ENSDART00000171325
tfe3a
transcription factor binding to IGHM enhancer 3a
chr12_-_28537615 1.92 ENSDART00000067762
MYO1D
si:ch211-94l19.4
chr2_+_11205795 1.91 ENSDART00000019078
lhx8a
LIM homeobox 8a
chr5_+_3891485 1.90 ENSDART00000129329
ENSDART00000091711
rpain
RPA interacting protein
chr22_-_28777374 1.84 ENSDART00000188206
si:dkeyp-34c12.1
si:dkeyp-34c12.1
chr23_+_13533885 1.84 ENSDART00000144386
uckl1b
uridine-cytidine kinase 1-like 1b
chr11_+_2710530 1.82 ENSDART00000132768
ENSDART00000030921
ENSDART00000040147
mapk14b
mitogen-activated protein kinase 14b
chr6_-_39700965 1.82 ENSDART00000156645
espl1
extra spindle pole bodies like 1, separase
chr4_-_1720648 1.78 ENSDART00000103484
gas2l3
growth arrest-specific 2 like 3
chr19_-_3821678 1.76 ENSDART00000169639
si:dkey-206d17.12
si:dkey-206d17.12
chr15_-_37589600 1.76 ENSDART00000154641
proser3
proline and serine rich 3
chr10_-_38243579 1.73 ENSDART00000150159
usp25
ubiquitin specific peptidase 25
chr6_-_13022166 1.71 ENSDART00000157139
tmbim1a
transmembrane BAX inhibitor motif containing 1a
chr9_-_12659140 1.69 ENSDART00000058565
pttg1ipb
PTTG1 interacting protein b
chr21_-_13661631 1.68 ENSDART00000184408
pnpla7a
patatin-like phospholipase domain containing 7a
chr7_+_33372680 1.68 ENSDART00000193436
ENSDART00000099988
glceb
glucuronic acid epimerase b
chr5_+_22579975 1.67 ENSDART00000080877
tnfsf10l4
tumor necrosis factor (ligand) superfamily, member 10 like 4
chr5_-_18897482 1.66 ENSDART00000010101
ENSDART00000099434
aacs
acetoacetyl-CoA synthetase
chr13_-_25842074 1.64 ENSDART00000015154
papolg
poly(A) polymerase gamma
chr21_-_41588129 1.64 ENSDART00000164125
crebrf
creb3 regulatory factor
chr21_+_19547806 1.63 ENSDART00000159707
ENSDART00000184869
ENSDART00000181321
ENSDART00000058487
ENSDART00000058485
rai14
retinoic acid induced 14
chr5_-_65121747 1.63 ENSDART00000165556
tor2a
torsin family 2, member A
chr9_+_2343096 1.61 ENSDART00000062292
ENSDART00000191722
ENSDART00000135180
atf2
activating transcription factor 2
chr4_+_11723852 1.61 ENSDART00000028820
mkln1
muskelin 1, intracellular mediator containing kelch motifs
chr17_-_2690083 1.59 ENSDART00000135374
ptpn21
protein tyrosine phosphatase, non-receptor type 21
chr22_-_18240968 1.59 ENSDART00000027605
tmem161a
transmembrane protein 161A
chr21_-_13662237 1.58 ENSDART00000091647
ENSDART00000151547
pnpla7a
patatin-like phospholipase domain containing 7a
chr9_+_24088062 1.57 ENSDART00000126198
lrrfip1a
leucine rich repeat (in FLII) interacting protein 1a
chr15_+_25681044 1.57 ENSDART00000077853
hic1
hypermethylated in cancer 1
chr2_-_24603325 1.55 ENSDART00000113356
crtc1a
CREB regulated transcription coactivator 1a
chr1_-_8917902 1.55 ENSDART00000137900
grin2ab
glutamate receptor, ionotropic, N-methyl D-aspartate 2A, b
chr14_-_32824380 1.55 ENSDART00000172791
ENSDART00000105745
inppl1b
inositol polyphosphate phosphatase-like 1b
chr3_+_19685873 1.55 ENSDART00000006490
tlk2
tousled-like kinase 2
chr5_+_22836364 1.54 ENSDART00000131885
si:ch211-26b3.2
si:ch211-26b3.2
chr5_+_37504309 1.53 ENSDART00000165465
si:ch1073-224n8.1
si:ch1073-224n8.1
chr23_+_44236281 1.53 ENSDART00000149842
MEPCE
si:ch1073-157b13.1
chr20_-_21806059 1.53 ENSDART00000145807
ENSDART00000152768
ENSDART00000152145
si:ch211-207i1.2
si:ch211-207i1.2
chr25_+_7494181 1.52 ENSDART00000165005
cat
catalase
chr24_+_21192431 1.51 ENSDART00000152027
usf3
upstream transcription factor family member 3
chr18_+_1703984 1.51 ENSDART00000114010
slitrk3a
SLIT and NTRK-like family, member 3a
chr21_-_43398122 1.50 ENSDART00000050533
ccni2
cyclin I family, member 2
chr11_-_34577034 1.50 ENSDART00000133302
ENSDART00000184367
pfkfb4a
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4a
chr15_+_22867174 1.50 ENSDART00000035812
grik4
glutamate receptor, ionotropic, kainate 4
chr3_-_26191960 1.49 ENSDART00000113843
ypel3
yippee-like 3
chr14_-_32876280 1.48 ENSDART00000173168
si:rp71-46j2.7
si:rp71-46j2.7
chr10_-_6588793 1.47 ENSDART00000163788
chd1
chromodomain helicase DNA binding protein 1
chr3_+_32411343 1.47 ENSDART00000186287
ENSDART00000141793
rras
RAS related
chr12_+_18916285 1.47 ENSDART00000127536
cbx7b
chromobox homolog 7b
chr8_+_8643901 1.46 ENSDART00000142076
ENSDART00000075624
usp11
ubiquitin specific peptidase 11
chr5_-_66749535 1.46 ENSDART00000132183
kat5b
K(lysine) acetyltransferase 5b
chr2_+_1988036 1.45 ENSDART00000155956
ssx2ipa
synovial sarcoma, X breakpoint 2 interacting protein a
chr16_-_13612650 1.45 ENSDART00000080372
dbpb
D site albumin promoter binding protein b
chr17_+_24111392 1.45 ENSDART00000180123
ENSDART00000182787
ENSDART00000189752
ENSDART00000184940
ENSDART00000185363
ENSDART00000064067
ehbp1
EH domain binding protein 1
chr18_-_20466061 1.43 ENSDART00000060311
paqr5a
progestin and adipoQ receptor family member Va
chr3_-_60711127 1.43 ENSDART00000184119
ubald2
UBA-like domain containing 2
chr7_-_51749683 1.42 ENSDART00000083190
hdac8
histone deacetylase 8
chr9_+_37366973 1.41 ENSDART00000016370
dirc2
disrupted in renal carcinoma 2
chr20_+_53368611 1.41 ENSDART00000060432
cdc40
cell division cycle 40 homolog (S. cerevisiae)
chr17_-_9962578 1.40 ENSDART00000021942
eapp
e2f-associated phosphoprotein
chr11_-_25257045 1.37 ENSDART00000130477
snai1a
snail family zinc finger 1a
chr1_-_23308225 1.37 ENSDART00000137567
ENSDART00000008201
smim14
small integral membrane protein 14
chr1_+_51191049 1.36 ENSDART00000132244
ENSDART00000014970
ENSDART00000132141
btbd3a
BTB (POZ) domain containing 3a
chr3_-_36419641 1.36 ENSDART00000173545
cog1
component of oligomeric golgi complex 1
chr7_-_46019756 1.36 ENSDART00000162583
zgc:162297
zgc:162297
chr8_-_51599036 1.35 ENSDART00000175779
ENSDART00000134614
ENSDART00000098263
kctd9a
potassium channel tetramerization domain containing 9a
chr3_-_33113879 1.35 ENSDART00000044677
rarab
retinoic acid receptor, alpha b
chr6_-_9565526 1.33 ENSDART00000151470
map3k2
mitogen-activated protein kinase kinase kinase 2
chr5_-_4931266 1.32 ENSDART00000067600
zbtb43
zinc finger and BTB domain containing 43
chr15_-_28587147 1.32 ENSDART00000156049
ssh2a
slingshot protein phosphatase 2a
chr13_-_5257303 1.32 ENSDART00000110610
si:dkey-78p8.1
si:dkey-78p8.1
chr10_+_33754967 1.31 ENSDART00000153442
rxfp2a
relaxin/insulin-like family peptide receptor 2a
chr9_+_2041535 1.31 ENSDART00000093187
lnpa
limb and neural patterns a
chr5_-_20678300 1.30 ENSDART00000088639
wscd2
WSC domain containing 2
chr20_-_9428021 1.30 ENSDART00000025330
rdh14b
retinol dehydrogenase 14b
chr24_-_21343982 1.29 ENSDART00000012653
spice1
spindle and centriole associated protein 1
chr3_-_60142530 1.28 ENSDART00000153247
si:ch211-120g10.1
si:ch211-120g10.1
chr15_+_39977461 1.28 ENSDART00000063786
cab39
calcium binding protein 39
chr24_-_19718077 1.28 ENSDART00000109107
ENSDART00000056082
csrnp1b
cysteine-serine-rich nuclear protein 1b
chr21_+_17051478 1.28 ENSDART00000047201
ENSDART00000161650
ENSDART00000167298
atp2a2a
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2a
chr12_-_22509069 1.27 ENSDART00000179755
ENSDART00000109707
neurl4
neuralized E3 ubiquitin protein ligase 4
chr16_-_49646625 1.27 ENSDART00000101629
efhb
EF-hand domain family, member B
chr20_-_31497300 1.27 ENSDART00000046841
sash1a
SAM and SH3 domain containing 1a
chr12_-_9498060 1.25 ENSDART00000160622
si:ch211-207i20.2
si:ch211-207i20.2
chr3_-_25369557 1.25 ENSDART00000055491
smurf2
SMAD specific E3 ubiquitin protein ligase 2
chr9_+_17971935 1.24 ENSDART00000149736
akap11
A kinase (PRKA) anchor protein 11
chr10_-_35186310 1.24 ENSDART00000127805
pom121
POM121 transmembrane nucleoporin
chr7_-_37555208 1.24 ENSDART00000148905
ENSDART00000150229
cylda
cylindromatosis (turban tumor syndrome), a
chr8_+_17869225 1.23 ENSDART00000080079
slc44a5b
solute carrier family 44, member 5b
chr20_+_1385674 1.22 ENSDART00000145981
mmachc
methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
chr5_+_55934129 1.22 ENSDART00000050969
tmem150ab
transmembrane protein 150Ab
chr16_-_54971277 1.21 ENSDART00000113358
wdtc1
WD and tetratricopeptide repeats 1
chr19_-_5103141 1.21 ENSDART00000150952
tpi1a
triosephosphate isomerase 1a
chr19_-_5103313 1.20 ENSDART00000037007
tpi1a
triosephosphate isomerase 1a
chr22_-_5171362 1.20 ENSDART00000124889
tnfaip8l1
tumor necrosis factor, alpha-induced protein 8-like 1
chr22_-_29689981 1.20 ENSDART00000009223
pdcd4b
programmed cell death 4b
chr24_+_14240196 1.19 ENSDART00000124740
ncoa2
nuclear receptor coactivator 2
chr22_-_3449282 1.19 ENSDART00000136798
ptprsa
protein tyrosine phosphatase, receptor type, s, a
chr19_+_22074468 1.18 ENSDART00000136294
ENSDART00000090476
atp9b
ATPase phospholipid transporting 9B
chr5_-_68058168 1.18 ENSDART00000177026
rnf167
ring finger protein 167
chr18_+_41561285 1.18 ENSDART00000169621
baz1b
bromodomain adjacent to zinc finger domain, 1B
chr8_+_26034623 1.18 ENSDART00000004521
ENSDART00000142555
arih2
ariadne homolog 2 (Drosophila)
chr20_-_45062514 1.17 ENSDART00000183529
ENSDART00000182955
klhl29
kelch-like family member 29
chr15_-_28587490 1.17 ENSDART00000186196
ssh2a
slingshot protein phosphatase 2a
chr11_-_26701611 1.17 ENSDART00000083010
acad9
acyl-CoA dehydrogenase family, member 9
chr11_-_36001495 1.17 ENSDART00000190330
itpr1b
inositol 1,4,5-trisphosphate receptor, type 1b
chr5_+_42259002 1.16 ENSDART00000083778
eral1
Era-like 12S mitochondrial rRNA chaperone 1
chr11_-_25257595 1.16 ENSDART00000123567
snai1a
snail family zinc finger 1a
chr7_-_40630698 1.15 ENSDART00000134547
ube3c
ubiquitin protein ligase E3C
chr15_+_34069746 1.15 ENSDART00000163513
arl4aa
ADP-ribosylation factor-like 4aa
chr19_-_7272921 1.15 ENSDART00000102075
ENSDART00000132887
ENSDART00000130234
ENSDART00000193535
ENSDART00000136528
rxrba
retinoid x receptor, beta a
chr19_+_40115977 1.14 ENSDART00000139802
si:ch211-173p18.3
si:ch211-173p18.3
chr1_+_45839927 1.14 ENSDART00000148086
ENSDART00000180413
ENSDART00000048191
ENSDART00000179047
map2k7
mitogen-activated protein kinase kinase 7
chr16_+_40954481 1.14 ENSDART00000058587
gbp
glycogen synthase kinase binding protein
chr9_+_41459759 1.13 ENSDART00000132501
ENSDART00000100265
nemp2
nuclear envelope integral membrane protein 2
chr12_+_23812530 1.12 ENSDART00000066331
svila
supervillin a
chr18_-_21047580 1.12 ENSDART00000010189
igf1ra
insulin-like growth factor 1a receptor
chr25_-_13408760 1.11 ENSDART00000154445
gins3
GINS complex subunit 3
chr5_+_44944778 1.11 ENSDART00000130428
ENSDART00000044361
ENSDART00000128825
ENSDART00000124637
ENSDART00000126066
ENSDART00000177635
dmrt1
doublesex and mab-3 related transcription factor 1
chr16_-_15988320 1.11 ENSDART00000160883
CABZ01060453.1

chr13_+_12761707 1.10 ENSDART00000015127
zgc:100846
zgc:100846
chr3_+_35498119 1.09 ENSDART00000178963
tnrc6a
trinucleotide repeat containing 6a
chr3_+_10152092 1.09 ENSDART00000066053
cbx2
chromobox homolog 2 (Drosophila Pc class)
chr17_+_25856671 1.08 ENSDART00000064817
wapla
WAPL cohesin release factor a
chr5_+_1965296 1.07 ENSDART00000156224
dhx33
DEAH (Asp-Glu-Ala-His) box polypeptide 33
chr16_+_5612547 1.07 ENSDART00000140226
ENSDART00000189352
CYTH2
si:dkey-283b15.4
chr8_+_12951155 1.07 ENSDART00000081601
cept1a
choline/ethanolamine phosphotransferase 1a
chr19_+_4892281 1.06 ENSDART00000150969
cdk12
cyclin-dependent kinase 12
chr12_+_27704015 1.06 ENSDART00000153256
cacna1g
calcium channel, voltage-dependent, T type, alpha 1G subunit
chr5_+_36611128 1.06 ENSDART00000097684
nova1
neuro-oncological ventral antigen 1
chr23_+_31942040 1.06 ENSDART00000088607
nemp1
nuclear envelope integral membrane protein 1
chr15_+_46386261 1.04 ENSDART00000191793
igsf11
immunoglobulin superfamily member 11
chr21_-_9782502 1.04 ENSDART00000158836
arhgap24
Rho GTPase activating protein 24
chr25_+_34938317 1.03 ENSDART00000042678
vps4a
vacuolar protein sorting 4a homolog A (S. cerevisiae)
chr6_+_18367388 1.03 ENSDART00000163394
dgke
diacylglycerol kinase, epsilon
chr2_-_26603958 1.03 ENSDART00000143085
yipf1
Yip1 domain family, member 1
chr10_-_33343244 1.03 ENSDART00000164191
c2cd2
C2 calcium-dependent domain containing 2
chr4_+_8376362 1.02 ENSDART00000138653
ENSDART00000132647
erc1b
ELKS/RAB6-interacting/CAST family member 1b
chr5_+_44846280 1.02 ENSDART00000084370
kank1a
KN motif and ankyrin repeat domains 1a
chr18_+_20226843 1.02 ENSDART00000100632
tle3a
transducin-like enhancer of split 3a
chr14_-_33177935 1.02 ENSDART00000180583
ENSDART00000078856
dlg3
discs, large homolog 3 (Drosophila)
chr6_-_8244474 1.02 ENSDART00000151358
rgl3a
ral guanine nucleotide dissociation stimulator-like 3a
chr10_-_41156348 1.01 ENSDART00000058622
aak1b
AP2 associated kinase 1b
chr5_+_52625975 1.00 ENSDART00000170341
ENSDART00000168317
apba1a
amyloid beta (A4) precursor protein-binding, family A, member 1a
chr2_+_16696052 1.00 ENSDART00000022356
ENSDART00000164329
ppp1r7
protein phosphatase 1, regulatory (inhibitor) subunit 7
chr8_-_1267247 0.99 ENSDART00000150064
cdc14b
cell division cycle 14B
chr23_-_27589754 0.99 ENSDART00000138381
ENSDART00000133721
si:ch211-156j22.4
si:ch211-156j22.4
chr24_-_5932982 0.99 ENSDART00000138412
ENSDART00000135124
ENSDART00000007373
acbd5a
acyl-CoA binding domain containing 5a
chr6_-_32834385 0.99 ENSDART00000129803
zc3h3
zinc finger CCCH-type containing 3
chr3_-_26787430 0.98 ENSDART00000087047
rab40c
RAB40c, member RAS oncogene family
chr13_-_13030851 0.98 ENSDART00000009499
nsd2
nuclear receptor binding SET domain protein 2
chr23_+_21978584 0.98 ENSDART00000145172
eif4g3b
eukaryotic translation initiation factor 4 gamma, 3b
chr20_+_23742574 0.97 ENSDART00000050559
sh3rf1
SH3 domain containing ring finger 1
chr25_+_22017182 0.97 ENSDART00000156517
si:dkey-217l24.1
si:dkey-217l24.1
chr10_+_573667 0.97 ENSDART00000110384
smad4a
SMAD family member 4a
chr10_-_28519505 0.96 ENSDART00000137964
bbx
bobby sox homolog (Drosophila)
chr15_+_46313082 0.96 ENSDART00000153830
si:ch1073-190k2.1
si:ch1073-190k2.1
chr6_-_40922971 0.96 ENSDART00000155363
sfi1
SFI1 centrin binding protein
chr10_-_38243851 0.96 ENSDART00000166108
usp25
ubiquitin specific peptidase 25
chr5_-_40190949 0.96 ENSDART00000175588
wdfy3
WD repeat and FYVE domain containing 3
chr20_+_22799857 0.94 ENSDART00000058527
scfd2
sec1 family domain containing 2
chr21_-_22435957 0.94 ENSDART00000137959
il7r
interleukin 7 receptor
chr7_-_51749895 0.93 ENSDART00000175523
ENSDART00000189639
hdac8
histone deacetylase 8
chr22_-_29689485 0.92 ENSDART00000182173
pdcd4b
programmed cell death 4b
chr10_-_8197049 0.92 ENSDART00000129467
dhx29
DEAH (Asp-Glu-Ala-His) box polypeptide 29
chr7_+_40205394 0.91 ENSDART00000173742
ENSDART00000148390
ncapg2
non-SMC condensin II complex, subunit G2

Network of associatons between targets according to the STRING database.

First level regulatory network of foxo4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.2 GO:0060571 invagination involved in gastrulation with mouth forming second(GO:0055109) morphogenesis of an epithelial fold(GO:0060571)
0.6 2.4 GO:0046166 methylglyoxal biosynthetic process(GO:0019242) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.5 2.0 GO:1904182 regulation of pyruvate dehydrogenase activity(GO:1904182) positive regulation of pyruvate dehydrogenase activity(GO:1904184)
0.5 1.0 GO:0036037 CD8-positive, alpha-beta T cell activation(GO:0036037)
0.5 3.2 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
0.5 2.3 GO:0008592 regulation of Toll signaling pathway(GO:0008592)
0.4 1.8 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.4 1.3 GO:1903373 regulation of endoplasmic reticulum tubular network organization(GO:1903371) positive regulation of endoplasmic reticulum tubular network organization(GO:1903373)
0.4 1.1 GO:0030238 male sex determination(GO:0030238)
0.4 1.1 GO:0060623 regulation of chromosome condensation(GO:0060623)
0.3 1.0 GO:0097676 histone H3-K36 dimethylation(GO:0097676)
0.3 4.2 GO:0045762 activation of adenylate cyclase activity(GO:0007190) positive regulation of cAMP metabolic process(GO:0030816) positive regulation of cAMP biosynthetic process(GO:0030819) positive regulation of adenylate cyclase activity(GO:0045762)
0.3 2.6 GO:0045338 farnesyl diphosphate metabolic process(GO:0045338)
0.3 2.1 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.3 1.2 GO:0045922 negative regulation of fatty acid metabolic process(GO:0045922)
0.3 0.9 GO:0018008 N-terminal protein myristoylation(GO:0006499) N-terminal peptidyl-glycine N-myristoylation(GO:0018008) protein myristoylation(GO:0018377)
0.3 2.4 GO:0070933 histone H4 deacetylation(GO:0070933)
0.3 1.3 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.3 1.8 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.3 1.8 GO:0021534 cell proliferation in hindbrain(GO:0021534)
0.2 0.7 GO:0071896 protein localization to adherens junction(GO:0071896)
0.2 1.8 GO:0044211 CTP salvage(GO:0044211)
0.2 0.9 GO:1990167 protein K27-linked deubiquitination(GO:1990167)
0.2 0.7 GO:0050428 sulfate assimilation(GO:0000103) purine ribonucleoside bisphosphate metabolic process(GO:0034035) purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428)
0.2 0.7 GO:0043455 regulation of secondary metabolic process(GO:0043455)
0.2 1.2 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.2 1.2 GO:1990108 protein linear deubiquitination(GO:1990108)
0.2 0.8 GO:0061031 endodermal digestive tract morphogenesis(GO:0061031) pancreas morphogenesis(GO:0061113)
0.2 0.8 GO:1900181 regulation of protein import into nucleus(GO:0042306) negative regulation of protein import into nucleus(GO:0042308) negative regulation of nucleocytoplasmic transport(GO:0046823) negative regulation of protein localization to nucleus(GO:1900181) regulation of protein import(GO:1904589) negative regulation of protein import(GO:1904590)
0.2 1.5 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.2 1.3 GO:0045943 positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.2 0.8 GO:0006116 NADH oxidation(GO:0006116) glycerol-3-phosphate catabolic process(GO:0046168)
0.2 0.8 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.2 0.6 GO:0090069 regulation of ribosome biogenesis(GO:0090069)
0.2 0.5 GO:0010935 macrophage cytokine production(GO:0010934) regulation of macrophage cytokine production(GO:0010935) positive regulation of macrophage cytokine production(GO:0060907) negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
0.2 0.9 GO:0010591 regulation of lamellipodium assembly(GO:0010591)
0.2 1.0 GO:1900028 wound healing, spreading of epidermal cells(GO:0035313) negative regulation of ruffle assembly(GO:1900028)
0.2 0.7 GO:0044210 'de novo' CTP biosynthetic process(GO:0044210)
0.2 2.4 GO:0046599 regulation of centriole replication(GO:0046599)
0.2 0.5 GO:0032957 inositol trisphosphate metabolic process(GO:0032957)
0.2 1.7 GO:0032024 positive regulation of insulin secretion(GO:0032024)
0.2 1.0 GO:0030242 pexophagy(GO:0030242)
0.2 0.7 GO:0019532 oxalate transport(GO:0019532)
0.2 1.1 GO:1902975 cell cycle DNA replication initiation(GO:1902292) nuclear cell cycle DNA replication initiation(GO:1902315) mitotic DNA replication initiation(GO:1902975)
0.2 1.1 GO:0036268 swimming(GO:0036268)
0.2 0.8 GO:1901842 regulation of high voltage-gated calcium channel activity(GO:1901841) negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.1 1.9 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.1 1.5 GO:0045199 maintenance of apical/basal cell polarity(GO:0035090) maintenance of epithelial cell apical/basal polarity(GO:0045199)
0.1 0.9 GO:0042753 positive regulation of circadian rhythm(GO:0042753)
0.1 1.7 GO:0030202 heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.1 1.4 GO:1904263 positive regulation of TORC1 signaling(GO:1904263)
0.1 0.7 GO:0051972 regulation of telomerase activity(GO:0051972)
0.1 1.2 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.1 1.4 GO:0003139 secondary heart field specification(GO:0003139)
0.1 2.5 GO:0008078 mesodermal cell migration(GO:0008078)
0.1 4.4 GO:0045332 phospholipid translocation(GO:0045332)
0.1 0.8 GO:0060251 regulation of glial cell proliferation(GO:0060251)
0.1 1.5 GO:0048009 insulin-like growth factor receptor signaling pathway(GO:0048009)
0.1 10.4 GO:0032272 negative regulation of actin filament polymerization(GO:0030837) negative regulation of protein polymerization(GO:0032272)
0.1 1.0 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.1 2.3 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.1 0.4 GO:0009098 leucine biosynthetic process(GO:0009098)
0.1 1.0 GO:0061056 sclerotome development(GO:0061056)
0.1 0.4 GO:1900136 regulation of cytokine activity(GO:0060300) regulation of receptor binding(GO:1900120) regulation of chemokine activity(GO:1900136)
0.1 1.3 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 1.0 GO:0006032 chitin catabolic process(GO:0006032)
0.1 0.9 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.1 0.5 GO:0006004 fucose metabolic process(GO:0006004)
0.1 0.8 GO:0043981 histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.1 1.1 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.1 0.4 GO:0061010 gall bladder development(GO:0061010)
0.1 1.2 GO:0099560 synaptic membrane adhesion(GO:0099560)
0.1 1.5 GO:0046688 response to copper ion(GO:0046688)
0.1 2.1 GO:0003171 atrioventricular valve development(GO:0003171)
0.1 1.6 GO:0006198 cAMP catabolic process(GO:0006198)
0.1 1.9 GO:0021884 forebrain neuron development(GO:0021884)
0.1 1.4 GO:0060079 excitatory postsynaptic potential(GO:0060079)
0.1 0.3 GO:0071926 endocannabinoid signaling pathway(GO:0071926) retrograde trans-synaptic signaling by lipid(GO:0098920) retrograde trans-synaptic signaling by endocannabinoid(GO:0098921)
0.1 1.1 GO:0015858 nucleoside transport(GO:0015858) nucleoside transmembrane transport(GO:1901642)
0.1 0.7 GO:0051295 establishment of meiotic spindle localization(GO:0051295)
0.1 4.8 GO:0044744 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) single-organism nuclear import(GO:1902593)
0.1 0.9 GO:2000781 positive regulation of double-strand break repair(GO:2000781)
0.1 2.0 GO:0051307 meiotic chromosome separation(GO:0051307)
0.1 1.2 GO:0006767 water-soluble vitamin metabolic process(GO:0006767)
0.1 0.2 GO:0018211 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.1 0.7 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.1 0.8 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.1 0.6 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.1 1.1 GO:0045974 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.1 1.5 GO:0007257 activation of JUN kinase activity(GO:0007257) positive regulation of JUN kinase activity(GO:0043507)
0.1 1.0 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.1 3.5 GO:0016575 histone deacetylation(GO:0016575)
0.1 1.0 GO:0097324 melanocyte migration(GO:0097324)
0.1 3.3 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.1 0.8 GO:0051865 protein autoubiquitination(GO:0051865)
0.1 2.3 GO:0017015 regulation of transforming growth factor beta receptor signaling pathway(GO:0017015) regulation of cellular response to transforming growth factor beta stimulus(GO:1903844)
0.1 1.5 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.1 0.5 GO:0006449 regulation of translational termination(GO:0006449)
0.1 0.2 GO:0032206 positive regulation of telomere maintenance(GO:0032206) regulation of telomere capping(GO:1904353) positive regulation of telomere capping(GO:1904355)
0.1 1.6 GO:0006378 mRNA polyadenylation(GO:0006378) RNA polyadenylation(GO:0043631)
0.1 1.6 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.1 0.8 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.1 0.6 GO:0070307 lens fiber cell development(GO:0070307) lens fiber cell morphogenesis(GO:0070309)
0.1 3.0 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.1 0.9 GO:0022011 myelination in peripheral nervous system(GO:0022011)
0.1 0.2 GO:0036315 response to sterol(GO:0036314) cellular response to sterol(GO:0036315) SREBP-SCAP complex retention in endoplasmic reticulum(GO:0036316) regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.1 0.2 GO:0006530 asparagine catabolic process(GO:0006530) asparagine catabolic process via L-aspartate(GO:0033345)
0.1 1.2 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 1.6 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0 4.0 GO:0007030 Golgi organization(GO:0007030)
0.0 0.8 GO:0070193 synaptonemal complex assembly(GO:0007130) synaptonemal complex organization(GO:0070193)
0.0 0.3 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 1.4 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 1.0 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 2.0 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.0 2.4 GO:0000281 mitotic cytokinesis(GO:0000281)
0.0 1.1 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.0 0.5 GO:0045842 positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of chromosome segregation(GO:0051984) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101)
0.0 1.9 GO:0006986 response to unfolded protein(GO:0006986)
0.0 0.3 GO:0090398 cellular senescence(GO:0090398)
0.0 1.1 GO:0032526 response to retinoic acid(GO:0032526)
0.0 2.0 GO:0030901 midbrain development(GO:0030901)
0.0 1.2 GO:0051209 release of sequestered calcium ion into cytosol(GO:0051209)
0.0 0.8 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.0 1.5 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 1.0 GO:0043966 histone H3 acetylation(GO:0043966)
0.0 1.2 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)
0.0 1.6 GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage(GO:0008630)
0.0 0.8 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.0 1.0 GO:0048264 determination of ventral identity(GO:0048264)
0.0 1.0 GO:0061245 establishment or maintenance of apical/basal cell polarity(GO:0035088) establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197) establishment or maintenance of bipolar cell polarity(GO:0061245)
0.0 0.3 GO:0048790 maintenance of presynaptic active zone structure(GO:0048790) maintenance of synapse structure(GO:0099558)
0.0 0.7 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 1.6 GO:0001837 epithelial to mesenchymal transition(GO:0001837)
0.0 1.2 GO:0030851 granulocyte differentiation(GO:0030851)
0.0 1.4 GO:0071599 otic vesicle development(GO:0071599)
0.0 0.1 GO:1990918 double-strand break repair involved in meiotic recombination(GO:1990918)
0.0 0.9 GO:0030261 chromosome condensation(GO:0030261)
0.0 1.4 GO:0048477 oogenesis(GO:0048477)
0.0 0.6 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.2 GO:1902624 positive regulation of neutrophil migration(GO:1902624)
0.0 0.1 GO:0006046 N-acetylglucosamine catabolic process(GO:0006046)
0.0 0.7 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.3 GO:0060971 embryonic heart tube left/right pattern formation(GO:0060971)
0.0 0.3 GO:0051382 kinetochore assembly(GO:0051382)
0.0 0.7 GO:0009648 photoperiodism(GO:0009648)
0.0 0.5 GO:0010821 regulation of mitochondrion organization(GO:0010821)
0.0 0.3 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
0.0 3.0 GO:0006338 chromatin remodeling(GO:0006338)
0.0 3.1 GO:0009953 dorsal/ventral pattern formation(GO:0009953)
0.0 0.8 GO:0045732 positive regulation of protein catabolic process(GO:0045732)
0.0 0.2 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.0 2.3 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.1 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.0 0.3 GO:0032264 IMP salvage(GO:0032264)
0.0 0.2 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 1.9 GO:0006413 translational initiation(GO:0006413)
0.0 0.4 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 0.3 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 1.5 GO:0035249 synaptic transmission, glutamatergic(GO:0035249)
0.0 0.5 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 0.4 GO:1902850 mitotic spindle assembly(GO:0090307) microtubule cytoskeleton organization involved in mitosis(GO:1902850)
0.0 0.6 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 0.6 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.0 0.5 GO:0048821 erythrocyte development(GO:0048821)
0.0 0.6 GO:0016573 histone acetylation(GO:0016573)
0.0 1.2 GO:0021782 glial cell development(GO:0021782)
0.0 0.2 GO:0007032 endosome organization(GO:0007032)
0.0 0.7 GO:0001510 RNA methylation(GO:0001510)
0.0 1.3 GO:0000209 protein polyubiquitination(GO:0000209)
0.0 0.0 GO:0016554 cytidine to uridine editing(GO:0016554)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.5 GO:0097134 cyclin E1-CDK2 complex(GO:0097134)
0.4 1.3 GO:0098826 endoplasmic reticulum tubular network membrane(GO:0098826)
0.4 1.5 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.3 2.4 GO:0071797 LUBAC complex(GO:0071797)
0.2 1.1 GO:0005899 insulin receptor complex(GO:0005899)
0.2 0.7 GO:0097268 cytoophidium(GO:0097268)
0.2 0.6 GO:0017177 glucosidase II complex(GO:0017177)
0.2 0.5 GO:0031213 RSF complex(GO:0031213)
0.1 0.8 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1 0.8 GO:0000801 central element(GO:0000801)
0.1 0.4 GO:0005828 kinetochore microtubule(GO:0005828)
0.1 1.1 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024) nuclear cyclin-dependent protein kinase holoenzyme complex(GO:0019908)
0.1 0.9 GO:0000796 condensin complex(GO:0000796)
0.1 0.6 GO:0000811 GINS complex(GO:0000811)
0.1 2.6 GO:0035102 PRC1 complex(GO:0035102)
0.1 1.3 GO:0017119 Golgi transport complex(GO:0017119)
0.1 1.9 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 0.4 GO:1990513 CLOCK-BMAL transcription complex(GO:1990513)
0.1 1.5 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 1.5 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.1 5.9 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 0.7 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 1.6 GO:0032039 integrator complex(GO:0032039)
0.1 1.1 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 3.2 GO:0031941 filamentous actin(GO:0031941)
0.1 0.5 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 0.6 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 0.6 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.1 0.4 GO:0033557 Slx1-Slx4 complex(GO:0033557)
0.1 0.2 GO:0035301 Hedgehog signaling complex(GO:0035301)
0.1 2.4 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 1.2 GO:0030667 secretory granule membrane(GO:0030667)
0.1 0.2 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 1.3 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 1.0 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 1.4 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.4 GO:0032783 ELL-EAF complex(GO:0032783)
0.0 0.3 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 2.8 GO:0072686 mitotic spindle(GO:0072686)
0.0 0.2 GO:0098574 cytoplasmic side of lysosomal membrane(GO:0098574)
0.0 1.3 GO:0043596 nuclear replication fork(GO:0043596)
0.0 0.4 GO:0071782 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.0 1.0 GO:0048788 cytoskeleton of presynaptic active zone(GO:0048788)
0.0 0.7 GO:0000782 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783) nuclear chromosome, telomeric region(GO:0000784)
0.0 0.1 GO:0010369 chromocenter(GO:0010369)
0.0 0.6 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 3.2 GO:0036464 cytoplasmic ribonucleoprotein granule(GO:0036464)
0.0 1.3 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 3.5 GO:0016607 nuclear speck(GO:0016607)
0.0 0.6 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 0.6 GO:0005844 polysome(GO:0005844)
0.0 0.8 GO:0045495 pole plasm(GO:0045495)
0.0 3.2 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 0.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 3.6 GO:0005819 spindle(GO:0005819)
0.0 0.4 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 1.3 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.3 GO:1990246 uniplex complex(GO:1990246)
0.0 5.9 GO:0005730 nucleolus(GO:0005730)
0.0 0.1 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 1.0 GO:0031902 late endosome membrane(GO:0031902)
0.0 0.5 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.8 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.0 0.4 GO:0043195 terminal bouton(GO:0043195)
0.0 1.1 GO:0034704 voltage-gated calcium channel complex(GO:0005891) calcium channel complex(GO:0034704)
0.0 0.9 GO:0031901 early endosome membrane(GO:0031901)
0.0 1.0 GO:0098878 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0 0.2 GO:0042555 MCM complex(GO:0042555)
0.0 1.2 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 1.6 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 0.9 GO:0005884 actin filament(GO:0005884)
0.0 1.9 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 2.4 GO:0005912 adherens junction(GO:0005912)
0.0 1.9 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 1.2 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 1.0 GO:0000793 condensed chromosome(GO:0000793)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.6 2.5 GO:0051059 NF-kappaB binding(GO:0051059)
0.6 2.4 GO:0008929 triose-phosphate isomerase activity(GO:0004807) methylglyoxal synthase activity(GO:0008929)
0.5 2.0 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.4 1.7 GO:0047464 heparosan-N-sulfate-glucuronate 5-epimerase activity(GO:0047464)
0.4 1.6 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.4 1.2 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.4 1.5 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.3 2.1 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.3 0.9 GO:0004379 glycylpeptide N-tetradecanoyltransferase activity(GO:0004379)
0.2 1.7 GO:0035173 histone kinase activity(GO:0035173)
0.2 1.8 GO:0004849 uridine kinase activity(GO:0004849)
0.2 1.1 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.2 0.7 GO:0004779 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.2 1.1 GO:0005009 insulin-activated receptor activity(GO:0005009) insulin receptor substrate binding(GO:0043560)
0.2 0.7 GO:0016436 rRNA (uridine) methyltransferase activity(GO:0016436)
0.2 1.1 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142) ethanolaminephosphotransferase activity(GO:0004307)
0.2 1.8 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.2 0.8 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.2 1.1 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.2 0.7 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.2 0.7 GO:0003883 CTP synthase activity(GO:0003883)
0.2 0.5 GO:0052725 inositol tetrakisphosphate 1-kinase activity(GO:0047325) inositol-1,3,4-trisphosphate 6-kinase activity(GO:0052725) inositol-1,3,4-trisphosphate 5-kinase activity(GO:0052726)
0.2 2.4 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.2 0.5 GO:0045145 single-stranded DNA 5'-3' exodeoxyribonuclease activity(GO:0045145)
0.2 0.7 GO:0034416 bisphosphoglycerate phosphatase activity(GO:0034416)
0.2 0.8 GO:0070004 cysteine-type exopeptidase activity(GO:0070004)
0.2 1.2 GO:0031419 cobalamin binding(GO:0031419)
0.2 1.1 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.1 1.5 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.1 1.2 GO:0001222 transcription corepressor binding(GO:0001222)
0.1 0.4 GO:0031701 angiotensin receptor binding(GO:0031701)
0.1 1.2 GO:0004096 catalase activity(GO:0004096)
0.1 2.0 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.1 1.1 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 0.8 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.1 1.8 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 2.7 GO:0031267 small GTPase binding(GO:0031267)
0.1 0.4 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.1 1.0 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.1 2.7 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 1.1 GO:0030332 cyclin binding(GO:0030332)
0.1 1.2 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.1 1.2 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.1 1.3 GO:0004331 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.1 1.0 GO:0004568 chitinase activity(GO:0004568)
0.1 1.6 GO:0035497 cAMP response element binding(GO:0035497)
0.1 2.6 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.1 3.0 GO:0035064 methylated histone binding(GO:0035064)
0.1 1.3 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 2.7 GO:0004707 MAP kinase activity(GO:0004707)
0.1 0.8 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.1 2.5 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 0.5 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.1 3.3 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 1.6 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 1.7 GO:0016878 acid-thiol ligase activity(GO:0016878)
0.1 1.0 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.1 1.2 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 0.4 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 1.0 GO:0098882 structural constituent of presynaptic active zone(GO:0098882)
0.1 1.1 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.1 0.7 GO:0061665 SUMO ligase activity(GO:0061665)
0.1 1.2 GO:0050321 tau-protein kinase activity(GO:0050321)
0.1 1.7 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 1.0 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.3 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.0 0.9 GO:0003785 actin monomer binding(GO:0003785)
0.0 1.5 GO:0019003 GDP binding(GO:0019003)
0.0 1.6 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 1.0 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.4 GO:0043515 kinetochore binding(GO:0043515)
0.0 1.0 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.2 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.0 0.3 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.0 0.4 GO:0031994 insulin-like growth factor I binding(GO:0031994) insulin-like growth factor II binding(GO:0031995)
0.0 1.0 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 3.1 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.7 GO:0019104 DNA N-glycosylase activity(GO:0019104)
0.0 0.5 GO:0008417 fucosyltransferase activity(GO:0008417)
0.0 0.9 GO:0004312 fatty acid synthase activity(GO:0004312)
0.0 2.1 GO:0017124 SH3 domain binding(GO:0017124)
0.0 2.8 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 1.3 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 2.7 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.8 GO:0016876 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.0 4.6 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.8 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.6 GO:0016251 obsolete general RNA polymerase II transcription factor activity(GO:0016251)
0.0 1.4 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.4 GO:0043994 H3 histone acetyltransferase activity(GO:0010484) histone acetyltransferase activity (H3-K23 specific)(GO:0043994)
0.0 1.8 GO:0004521 endoribonuclease activity(GO:0004521)
0.0 0.2 GO:0008142 oxysterol binding(GO:0008142)
0.0 5.9 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 0.5 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.6 GO:0019213 deacetylase activity(GO:0019213)
0.0 0.3 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 3.9 GO:0042393 histone binding(GO:0042393)
0.0 8.9 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 0.1 GO:0003958 NADPH-hemoprotein reductase activity(GO:0003958)
0.0 2.7 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 3.1 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 0.6 GO:1990782 receptor tyrosine kinase binding(GO:0030971) protein tyrosine kinase binding(GO:1990782)
0.0 0.1 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 0.5 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 4.2 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.0 1.1 GO:0015370 solute:sodium symporter activity(GO:0015370)
0.0 2.3 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 3.0 GO:0004386 helicase activity(GO:0004386)
0.0 2.6 GO:0000287 magnesium ion binding(GO:0000287)
0.0 0.2 GO:0031682 G-protein gamma-subunit binding(GO:0031682)
0.0 0.7 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.0 1.2 GO:0019905 syntaxin binding(GO:0019905)
0.0 0.9 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 1.0 GO:0005496 steroid binding(GO:0005496)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.7 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.2 2.5 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 1.1 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.1 1.8 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 1.6 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 3.6 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.1 1.3 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 1.1 PID ARF 3PATHWAY Arf1 pathway
0.0 0.9 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.7 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 1.0 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 2.2 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 1.2 PID BMP PATHWAY BMP receptor signaling
0.0 0.5 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.5 PID IL1 PATHWAY IL1-mediated signaling events
0.0 0.3 PID AURORA A PATHWAY Aurora A signaling
0.0 0.6 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.8 PID FOXO PATHWAY FoxO family signaling
0.0 0.5 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.8 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.5 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.7 PID LKB1 PATHWAY LKB1 signaling events
0.0 1.0 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.0 0.3 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.8 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.7 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.4 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.4 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 0.2 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.5 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.2 2.3 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.2 0.6 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.2 2.5 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.2 0.8 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.2 2.0 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.2 1.5 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.2 1.6 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 3.3 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 2.3 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.1 2.5 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 1.2 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.1 1.8 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 2.2 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 1.2 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 0.6 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.1 0.9 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 1.1 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.1 0.9 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 1.1 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 4.0 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.1 0.7 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.1 2.2 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 0.4 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 1.0 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.1 1.0 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.1 0.4 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 0.9 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 1.3 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.7 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.6 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 2.6 REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm
0.0 0.5 REACTOME PRE NOTCH EXPRESSION AND PROCESSING Genes involved in Pre-NOTCH Expression and Processing
0.0 1.5 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.8 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.8 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.8 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.5 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.7 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.5 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.3 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.0 0.4 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.8 REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle
0.0 0.5 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.7 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.1 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.1 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.2 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions