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PRJNA195909:zebrafish embryo and larva development

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Results for gbx2

Z-value: 1.04

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Transcription factors associated with gbx2

Gene Symbol Gene ID Gene Info
gbx2
ENSDARG00000002933 gastrulation brain homeobox 2
gbx2
ENSDARG00000116377 gastrulation brain homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
gbx2dr11_v1_chr6_+_16031189_16031189-0.674.7e-02Click!

Activity profile of gbx2 motif

Sorted Z-values of gbx2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_6452444 3.33 ENSDART00000137879
ENSDART00000134957
ENSDART00000004483
larp6b
La ribonucleoprotein domain family, member 6b
chr1_-_18811517 2.82 ENSDART00000142026
si:dkey-167i21.2
si:dkey-167i21.2
chr2_+_41926707 2.13 ENSDART00000023208
zgc:110183
zgc:110183
chr19_-_10330778 1.69 ENSDART00000081465
ENSDART00000136653
ENSDART00000171232
ccdc106b
coiled-coil domain containing 106b
chr7_+_46019780 1.68 ENSDART00000163991
ccne1
cyclin E1
chr23_+_42254960 1.66 ENSDART00000102980
zcchc11
zinc finger, CCHC domain containing 11
chr7_-_51727760 1.58 ENSDART00000174180
hdac8
histone deacetylase 8
chr7_+_59677273 1.54 ENSDART00000039535
ENSDART00000132044
trmt44
tRNA methyltransferase 44 homolog
chr8_+_23826985 1.52 ENSDART00000187430
mapk14a
mitogen-activated protein kinase 14a
chr20_-_49889111 1.41 ENSDART00000058858
kif13bb
kinesin family member 13Bb
chr5_-_20123002 1.35 ENSDART00000026516
pxmp2
peroxisomal membrane protein 2
chr14_+_35464994 1.31 ENSDART00000115307
si:ch211-203d1.3
si:ch211-203d1.3
chr10_-_14929630 1.31 ENSDART00000121892
ENSDART00000044756
ENSDART00000128579
ENSDART00000147653
smad2
SMAD family member 2
chr17_+_24318753 1.26 ENSDART00000064083
otx1
orthodenticle homeobox 1
chr12_-_35386910 1.24 ENSDART00000153453
camk2g1
calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1
chr22_-_9861531 1.18 ENSDART00000193197
si:dkey-253d23.2
si:dkey-253d23.2
chr15_-_16177603 1.14 ENSDART00000156352
si:ch211-259g3.4
si:ch211-259g3.4
chr2_-_26720854 1.09 ENSDART00000148110
si:dkey-181m9.8
si:dkey-181m9.8
chr24_-_20359350 1.02 ENSDART00000109223
dlec1
deleted in lung and esophageal cancer 1
chr15_+_34934568 0.96 ENSDART00000165210
zgc:66024
zgc:66024
chr7_+_20260172 0.96 ENSDART00000012450
dvl2
dishevelled segment polarity protein 2
chr12_+_5977777 0.93 ENSDART00000152302
si:ch211-131k2.2
si:ch211-131k2.2
chr1_+_18811679 0.93 ENSDART00000078610
slc25a51a
solute carrier family 25, member 51a
chr9_-_3934963 0.92 ENSDART00000062336
ubr3
ubiquitin protein ligase E3 component n-recognin 3
chr11_+_2855430 0.91 ENSDART00000172837
kif21b
kinesin family member 21B
chr24_+_33802528 0.90 ENSDART00000136040
ENSDART00000147499
ENSDART00000182322
atg9b
autophagy related 9B
chr7_-_46019756 0.88 ENSDART00000162583
zgc:162297
zgc:162297
chr7_-_33684632 0.86 ENSDART00000130553
tle3b
transducin-like enhancer of split 3b
chr11_-_29768054 0.86 ENSDART00000079117
plekha3
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3
chr24_-_26995164 0.85 ENSDART00000142864
stag1b
stromal antigen 1b
chr22_+_24157807 0.85 ENSDART00000159165
b3galt2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr18_+_26895994 0.83 ENSDART00000098347
ch25hl1.2
cholesterol 25-hydroxylase like 1, tandem duplicate 2
chr12_+_22560067 0.82 ENSDART00000172066
polr2a
polymerase (RNA) II (DNA directed) polypeptide A
chr5_-_25733745 0.82 ENSDART00000051566
zgc:101016
zgc:101016
chr12_-_20665164 0.77 ENSDART00000105352
gip
gastric inhibitory polypeptide
chr18_+_16750080 0.74 ENSDART00000136320
rnf141
ring finger protein 141
chr11_-_12158412 0.73 ENSDART00000147670
npepps
aminopeptidase puromycin sensitive
chr17_+_1496107 0.73 ENSDART00000187804
LO018430.1

chr22_+_2512154 0.72 ENSDART00000097363
zgc:173726
zgc:173726
chr20_-_7069612 0.72 ENSDART00000040793
sirt5
sirtuin 5
chr19_-_25149034 0.71 ENSDART00000148432
ENSDART00000175266
ptp4a3
protein tyrosine phosphatase type IVA, member 3
chr15_-_10341048 0.69 ENSDART00000171013
tenm4
teneurin transmembrane protein 4
chr19_-_20430892 0.69 ENSDART00000111409
tbc1d5
TBC1 domain family, member 5
chr24_-_33801668 0.69 ENSDART00000079202
abcb8
ATP-binding cassette, sub-family B (MDR/TAP), member 8
chr11_+_31323746 0.68 ENSDART00000180220
ENSDART00000189937
sipa1l2
signal-induced proliferation-associated 1 like 2
chr8_+_18010568 0.61 ENSDART00000121984
ssbp3b
single stranded DNA binding protein 3b
chr6_-_42369186 0.61 ENSDART00000039868
usp4
ubiquitin specific peptidase 4 (proto-oncogene)
chr24_-_32582378 0.57 ENSDART00000066590
rdh12l
retinol dehydrogenase 12, like
chr18_+_7639401 0.56 ENSDART00000092416
rabl2
RAB, member of RAS oncogene family-like 2
chr4_-_5019113 0.55 ENSDART00000189321
ENSDART00000081990
strip2
striatin interacting protein 2
chr20_-_18382708 0.52 ENSDART00000170864
ENSDART00000166762
ENSDART00000191333
vipas39
VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog
chr8_+_21229718 0.51 ENSDART00000100222
cry1ba
cryptochrome circadian clock 1ba
chr19_-_25149598 0.49 ENSDART00000162917
ptp4a3
protein tyrosine phosphatase type IVA, member 3
chr4_-_5018705 0.46 ENSDART00000154025
strip2
striatin interacting protein 2
chr18_-_16937008 0.45 ENSDART00000100117
ENSDART00000022640
ENSDART00000136541
znf143b
zinc finger protein 143b
chr20_-_7128612 0.44 ENSDART00000146755
ENSDART00000036871
si:ch211-121a2.4
si:ch211-121a2.4
chr24_-_32582880 0.44 ENSDART00000186307
rdh12l
retinol dehydrogenase 12, like
chr5_-_23843636 0.43 ENSDART00000193280
GBGT1 (1 of many)
si:ch211-135f11.5
chr18_+_17537344 0.42 ENSDART00000025782
nup93
nucleoporin 93
chr16_-_36093776 0.40 ENSDART00000159134
OSCP1
organic solute carrier partner 1
chr15_-_45110011 0.37 ENSDART00000182047
ENSDART00000188662
CABZ01072607.1

chr8_+_20140321 0.37 ENSDART00000012120
acsbg2
acyl-CoA synthetase bubblegum family member 2
chr14_-_33351103 0.37 ENSDART00000010019
upf3b
UPF3B, regulator of nonsense mediated mRNA decay
chr2_+_35240485 0.36 ENSDART00000179804
tnr
tenascin R (restrictin, janusin)
chr17_+_10593398 0.35 ENSDART00000168897
ENSDART00000193989
ENSDART00000191664
ENSDART00000167188
mapkbp1
mitogen-activated protein kinase binding protein 1
chr16_-_26855936 0.35 ENSDART00000167320
ENSDART00000078119
ino80c
INO80 complex subunit C
chr8_+_23105117 0.34 ENSDART00000025171
ythdf1
YTH N(6)-methyladenosine RNA binding protein 1
chr18_+_8833251 0.34 ENSDART00000143519
impdh1a
IMP (inosine 5'-monophosphate) dehydrogenase 1a
chr23_+_4253957 0.26 ENSDART00000008761
arl6ip5b
ADP-ribosylation factor-like 6 interacting protein 5b
chr6_+_3717613 0.24 ENSDART00000184330
ssb
Sjogren syndrome antigen B (autoantigen La)
chr18_+_15644559 0.23 ENSDART00000061794
nr1h4
nuclear receptor subfamily 1, group H, member 4
chr23_-_35066816 0.20 ENSDART00000168731
ENSDART00000163731
BX294434.1

chr19_-_27336092 0.20 ENSDART00000176885
gtf2h4
general transcription factor IIH, polypeptide 4
chr12_-_20665865 0.19 ENSDART00000183922
gip
gastric inhibitory polypeptide
chr11_+_24340166 0.18 ENSDART00000188719
rbm39a
RNA binding motif protein 39a
chr7_+_53755054 0.18 ENSDART00000181629
neo1a
neogenin 1a
chr10_-_32920690 0.17 ENSDART00000136245
cux1a
cut-like homeobox 1a
chr11_+_16216909 0.17 ENSDART00000081035
ENSDART00000147190
slc25a26
solute carrier family 25 (S-adenosylmethionine carrier), member 26
chr9_+_23003208 0.17 ENSDART00000021060
eaf2
ELL associated factor 2
chr9_-_30555725 0.15 ENSDART00000079222
chaf1b
chromatin assembly factor 1, subunit B
chr24_-_16904234 0.13 ENSDART00000192879
mtrr
5-methyltetrahydrofolate-homocysteine methyltransferase reductase
chr22_+_980290 0.13 ENSDART00000065377
def6b
differentially expressed in FDCP 6b homolog (mouse)
chr8_-_18010097 0.12 ENSDART00000122730
ENSDART00000133666
acot11b
acyl-CoA thioesterase 11b
chr6_-_39218609 0.11 ENSDART00000133305
os9
osteosarcoma amplified 9, endoplasmic reticulum lectin
chr23_+_44349252 0.10 ENSDART00000097644
ephb4b
eph receptor B4b
chr8_-_25729542 0.10 ENSDART00000078149
ENSDART00000085779
foxp3a
forkhead box P3a
chr15_-_5524271 0.09 ENSDART00000130297
atg16l2
ATG16 autophagy related 16-like 2 (S. cerevisiae)
chr18_+_31057143 0.08 ENSDART00000164585
mvda
mevalonate (diphospho) decarboxylase a
chr13_-_330004 0.07 ENSDART00000093149
ddx21
DEAD (Asp-Glu-Ala-Asp) box helicase 21
chr5_-_69923241 0.05 ENSDART00000187389
fktn
fukutin
chr21_-_40348790 0.05 ENSDART00000178123
CR847523.1

chr3_-_10739625 0.02 ENSDART00000156144
zgc:112965
zgc:112965
chr10_-_39052264 0.02 ENSDART00000144036
igsf5a
immunoglobulin superfamily, member 5a
chr22_+_2417105 0.00 ENSDART00000106415
zgc:113220
zgc:113220

Network of associatons between targets according to the STRING database.

First level regulatory network of gbx2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.2 1.5 GO:0040016 embryonic cleavage(GO:0040016) positive regulation of myoblast fusion(GO:1901741)
0.2 1.4 GO:0072386 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.2 1.6 GO:0070933 histone H4 deacetylation(GO:0070933)
0.2 0.9 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.2 0.9 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.1 0.7 GO:0032289 central nervous system myelin formation(GO:0032289)
0.1 1.0 GO:0090179 establishment of planar polarity of embryonic epithelium(GO:0042249) establishment of planar polarity involved in neural tube closure(GO:0090177) regulation of establishment of planar polarity involved in neural tube closure(GO:0090178) planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.1 0.9 GO:0035627 ceramide transport(GO:0035627)
0.1 1.0 GO:0042304 regulation of fatty acid biosynthetic process(GO:0042304)
0.1 0.9 GO:0044805 late nucleophagy(GO:0044805)
0.1 0.4 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.1 1.3 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.1 0.8 GO:0030311 poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.0 1.5 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.6 GO:0034122 negative regulation of toll-like receptor signaling pathway(GO:0034122)
0.0 0.7 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 0.3 GO:0046037 GMP biosynthetic process(GO:0006177) GMP metabolic process(GO:0046037)
0.0 1.7 GO:1904029 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 1.2 GO:0072114 pronephros morphogenesis(GO:0072114)
0.0 0.3 GO:0061157 RNA destabilization(GO:0050779) mRNA destabilization(GO:0061157)
0.0 0.7 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.7 GO:0042181 ketone biosynthetic process(GO:0042181)
0.0 0.1 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.0 0.9 GO:0016126 sterol biosynthetic process(GO:0016126)
0.0 0.1 GO:0044034 viral genome replication(GO:0019079) negative stranded viral RNA replication(GO:0039689) viral RNA genome replication(GO:0039694) RNA replication(GO:0039703) multi-organism biosynthetic process(GO:0044034)
0.0 0.4 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.0 0.8 GO:0007062 sister chromatid cohesion(GO:0007062)
0.0 0.2 GO:0050728 negative regulation of inflammatory response(GO:0050728)
0.0 1.3 GO:0030837 negative regulation of actin filament polymerization(GO:0030837) negative regulation of protein polymerization(GO:0032272)
0.0 0.2 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.0 0.4 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 0.2 GO:0014812 muscle cell migration(GO:0014812)
0.0 0.9 GO:0090090 negative regulation of canonical Wnt signaling pathway(GO:0090090)
0.0 0.1 GO:0060049 regulation of protein glycosylation(GO:0060049)
0.0 1.4 GO:0090630 activation of GTPase activity(GO:0090630)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:0097134 cyclin E1-CDK2 complex(GO:0097134)
0.1 1.1 GO:0071797 LUBAC complex(GO:0071797)
0.1 0.7 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 1.3 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.1 GO:0033186 CAF-1 complex(GO:0033186)
0.0 0.8 GO:0008278 cohesin complex(GO:0008278)
0.0 0.9 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 0.2 GO:0000439 core TFIIH complex(GO:0000439)
0.0 0.3 GO:0033202 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 0.2 GO:0032783 ELL-EAF complex(GO:0032783)
0.0 1.6 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.4 GO:0034399 nuclear periphery(GO:0034399)
0.0 1.6 GO:0005871 kinesin complex(GO:0005871)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.3 0.9 GO:0031834 neurokinin receptor binding(GO:0031834) substance P receptor binding(GO:0031835)
0.2 0.7 GO:0000035 acyl binding(GO:0000035)
0.2 1.0 GO:0031769 glucagon receptor binding(GO:0031769)
0.2 0.9 GO:1902387 ceramide transporter activity(GO:0035620) ceramide 1-phosphate binding(GO:1902387) ceramide 1-phosphate transporter activity(GO:1902388)
0.1 0.8 GO:0000254 C-4 methylsterol oxidase activity(GO:0000254)
0.1 1.6 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1 1.3 GO:0070411 I-SMAD binding(GO:0070411)
0.1 0.8 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.1 0.3 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.1 0.3 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.0 1.5 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.2 GO:0032052 bile acid binding(GO:0032052)
0.0 0.1 GO:0030586 [methionine synthase] reductase activity(GO:0030586)
0.0 0.8 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.0 0.4 GO:0016405 CoA-ligase activity(GO:0016405)
0.0 0.2 GO:0051185 coenzyme transporter activity(GO:0051185)
0.0 0.2 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 1.7 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 1.2 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 1.0 GO:0005109 frizzled binding(GO:0005109)
0.0 0.7 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.9 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 0.1 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.0 1.3 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 1.6 GO:0003777 microtubule motor activity(GO:0003777)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 1.3 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 1.2 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 2.3 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 1.0 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 0.2 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.1 1.0 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1 1.7 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 0.7 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 1.0 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 1.6 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.2 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 0.8 REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm
0.0 0.2 REACTOME FORMATION OF THE HIV1 EARLY ELONGATION COMPLEX Genes involved in Formation of the HIV-1 Early Elongation Complex