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PRJNA195909:zebrafish embryo and larva development

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Results for gli2a+gli3

Z-value: 1.11

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Transcription factors associated with gli2a+gli3

Gene Symbol Gene ID Gene Info
gli2a
ENSDARG00000025641 GLI family zinc finger 2a
gli3
ENSDARG00000052131 GLI family zinc finger 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
gli3dr11_v1_chr24_-_11821505_118215050.723.0e-02Click!
gli2adr11_v1_chr9_+_37152564_371525640.373.3e-01Click!

Activity profile of gli2a+gli3 motif

Sorted Z-values of gli2a+gli3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_55131289 3.49 ENSDART00000111585
AL935210.1

chr3_+_55114097 2.70 ENSDART00000121686
hbbe1.1
hemoglobin beta embryonic-1.1
chr23_+_20422661 2.57 ENSDART00000144047
ENSDART00000104336
tnnc2
troponin C type 2 (fast)
chr3_+_55122662 2.29 ENSDART00000128380
hbbe1.2
hemoglobin beta embryonic-1.2
chr1_-_19845378 2.23 ENSDART00000139314
ENSDART00000132958
ENSDART00000147502
grhprb
glyoxylate reductase/hydroxypyruvate reductase b
chr7_-_8374950 2.17 ENSDART00000057101
aep1
aerolysin-like protein
chr10_-_22854758 1.92 ENSDART00000079449
and3
actinodin3
chr12_+_27117609 1.33 ENSDART00000076154
hoxb8b
homeobox B8b
chr5_+_51594209 1.23 ENSDART00000164668
ENSDART00000058403
ENSDART00000055857
ckmt2b
creatine kinase, mitochondrial 2b (sarcomeric)
chr25_-_28384954 1.18 ENSDART00000073500
ptprz1a
protein tyrosine phosphatase, receptor-type, Z polypeptide 1a
chr19_-_26235219 1.15 ENSDART00000104008
dtnbp1b
dystrobrevin binding protein 1b
chr12_-_464007 1.14 ENSDART00000106669
dhrs7cb
dehydrogenase/reductase (SDR family) member 7Cb
chr22_+_38173960 1.13 ENSDART00000010537
cp
ceruloplasmin
chr8_-_14484599 1.09 ENSDART00000057644
lhx4
LIM homeobox 4
chr8_+_31119548 1.09 ENSDART00000136578
syn1
synapsin I
chr10_-_8358396 1.08 ENSDART00000059322
csgalnact1a
chondroitin sulfate N-acetylgalactosaminyltransferase 1a
chr13_+_42124566 1.07 ENSDART00000074707
cdc42ep3
CDC42 effector protein (Rho GTPase binding) 3
chr8_+_29962635 1.02 ENSDART00000007640
ptch1
patched 1
chr8_-_47800754 1.01 ENSDART00000115050
ENSDART00000133669
kank3
KN motif and ankyrin repeat domains 3
chr23_+_28582865 1.01 ENSDART00000020296
l1cama
L1 cell adhesion molecule, paralog a
chr22_+_38762693 1.01 ENSDART00000015016
ENSDART00000150187
alpi.1
alkaline phosphatase, intestinal, tandem duplicate 1
chr14_+_25465346 0.96 ENSDART00000173436
si:dkey-280e21.3
si:dkey-280e21.3
chr10_+_18952271 0.93 ENSDART00000146517
dpysl2b
dihydropyrimidinase-like 2b
chr19_+_56351 0.93 ENSDART00000168334
col14a1b
collagen, type XIV, alpha 1b
chr19_-_10243148 0.93 ENSDART00000148073
shisa7b
shisa family member 7
chr11_+_37250839 0.92 ENSDART00000170209
il17rc
interleukin 17 receptor C
chr12_+_24562667 0.84 ENSDART00000056256
nrxn1a
neurexin 1a
chr14_-_215051 0.83 ENSDART00000054822
nkx3.2
NK3 homeobox 2
chr6_-_35106425 0.80 ENSDART00000165139
nos1apa
nitric oxide synthase 1 (neuronal) adaptor protein a
chr18_-_14836600 0.77 ENSDART00000045232
mtss1la
metastasis suppressor 1-like a
chr13_+_3252950 0.77 ENSDART00000020671
prph2b
peripherin 2b (retinal degeneration, slow)
chr7_-_15413019 0.75 ENSDART00000172147
si:ch211-106j24.1
si:ch211-106j24.1
chr12_-_17479078 0.75 ENSDART00000079115
papss2b
3'-phosphoadenosine 5'-phosphosulfate synthase 2b
chr24_+_18299175 0.74 ENSDART00000140994
tpk1
thiamin pyrophosphokinase 1
chr10_-_35542071 0.73 ENSDART00000162139
si:ch211-244c8.4
si:ch211-244c8.4
chr25_-_210730 0.72 ENSDART00000187580
FP236318.1

chr4_+_5132951 0.69 ENSDART00000103279
ccnd2b
cyclin D2, b
chr13_+_3954540 0.68 ENSDART00000092646
lrrc73
leucine rich repeat containing 73
chr2_-_33993533 0.67 ENSDART00000140910
ENSDART00000077304
ptch2
patched 2
chr25_+_7461624 0.66 ENSDART00000170569
syt12
synaptotagmin XII
chr4_-_75175407 0.66 ENSDART00000180125
CABZ01043953.1

chr6_-_35446110 0.65 ENSDART00000058773
rgs16
regulator of G protein signaling 16
chr1_-_470812 0.63 ENSDART00000192527
zgc:92518
zgc:92518
chr20_+_15552657 0.63 ENSDART00000063912
jun
Jun proto-oncogene, AP-1 transcription factor subunit
chr16_-_37964325 0.62 ENSDART00000148801
mrap2a
melanocortin 2 receptor accessory protein 2a
chr1_+_51479128 0.58 ENSDART00000028018
meis1a
Meis homeobox 1 a
chr7_-_15413188 0.58 ENSDART00000185980
si:ch211-106j24.1
si:ch211-106j24.1
chr25_+_30298377 0.57 ENSDART00000153622
C11orf96
chromosome 11 open reading frame 96
chr5_-_43959972 0.56 ENSDART00000180517
si:ch211-204c21.1
si:ch211-204c21.1
chr20_+_26095530 0.56 ENSDART00000139350
syne1a
spectrin repeat containing, nuclear envelope 1a
chr22_-_10487490 0.55 ENSDART00000064798
aspn
asporin (LRR class 1)
chr9_-_1984604 0.53 ENSDART00000082339
hoxd12a
homeobox D12a
chr17_-_42213822 0.52 ENSDART00000187904
ENSDART00000180029
nkx2.2a
NK2 homeobox 2a
chr21_+_22985078 0.52 ENSDART00000156491
lpar6b
lysophosphatidic acid receptor 6b
chr13_-_40726865 0.51 ENSDART00000099847
st3gal7
ST3 beta-galactoside alpha-2,3-sialyltransferase 7
chr13_+_30804367 0.50 ENSDART00000053946
cxcl12a
chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)
chr9_+_6587364 0.50 ENSDART00000122279
fhl2a
four and a half LIM domains 2a
chr20_+_27194833 0.50 ENSDART00000150072
si:dkey-85n7.8
si:dkey-85n7.8
chr7_+_73780936 0.49 ENSDART00000092691
pea15
proliferation and apoptosis adaptor protein 15
chr16_-_38067952 0.47 ENSDART00000114266
plekho1b
pleckstrin homology domain containing, family O member 1b
chr14_+_25464681 0.45 ENSDART00000067500
ENSDART00000187601
si:dkey-280e21.3
si:dkey-280e21.3
chr8_-_52859301 0.45 ENSDART00000162004
nr5a1a
nuclear receptor subfamily 5, group A, member 1a
chr5_-_23179319 0.44 ENSDART00000161883
ENSDART00000136260
si:dkey-114c15.5
si:dkey-114c15.5
chr10_-_1827225 0.43 ENSDART00000058627
epb41l4a
erythrocyte membrane protein band 4.1 like 4A
chr2_+_51783120 0.43 ENSDART00000177559
crygn1
crystallin, gamma N1
chr13_-_30150592 0.43 ENSDART00000143093
sar1ab
secretion associated, Ras related GTPase 1Ab
chr5_+_20693724 0.43 ENSDART00000141368
si:ch211-240b21.2
si:ch211-240b21.2
chr9_+_6587056 0.43 ENSDART00000193421
fhl2a
four and a half LIM domains 2a
chr6_-_49655879 0.42 ENSDART00000191594
apcdd1l
adenomatosis polyposis coli down-regulated 1-like
chr16_-_31644545 0.41 ENSDART00000181634
CR855311.5

chr6_-_10320676 0.41 ENSDART00000151247
scn1lab
sodium channel, voltage-gated, type I like, alpha b
chr5_-_14564878 0.40 ENSDART00000160511
sema4c
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
chr9_-_12736089 0.40 ENSDART00000088042
myo10l3
myosin X-like 3
chr15_-_35252522 0.40 ENSDART00000144153
ENSDART00000059195
mff
mitochondrial fission factor
chr6_+_7123980 0.40 ENSDART00000179738
ENSDART00000151311
si:ch211-237c6.4
si:ch211-237c6.4
chr10_-_24868581 0.39 ENSDART00000193055
CABZ01058107.1

chr16_+_37470717 0.39 ENSDART00000112003
ENSDART00000188431
ENSDART00000192837
adgrb1a
adhesion G protein-coupled receptor B1a
chr8_-_19216657 0.38 ENSDART00000135096
ENSDART00000135869
ENSDART00000145951
si:ch73-222f22.2
si:ch73-222f22.2
si:ch73-222f22.2
si:ch73-222f22.2
chr17_+_30587333 0.38 ENSDART00000156500
nhsl1a
NHS-like 1a
chr1_+_7956030 0.37 ENSDART00000159655
CR855320.1

chr6_+_54358529 0.37 ENSDART00000153704
anks1ab
ankyrin repeat and sterile alpha motif domain containing 1Ab
chr21_+_10739846 0.35 ENSDART00000084011
cplx4a
complexin 4a
chr17_+_15388479 0.32 ENSDART00000052439
si:ch211-266g18.6
si:ch211-266g18.6
chr10_+_26747755 0.32 ENSDART00000100329
f9b
coagulation factor IXb
chr21_-_45073764 0.31 ENSDART00000181390
ENSDART00000063714
rapgef6
Rap guanine nucleotide exchange factor (GEF) 6
chr21_-_5856050 0.31 ENSDART00000115367
CABZ01071020.1

chr20_-_28642061 0.30 ENSDART00000135513
rgs6
regulator of G protein signaling 6
chr20_-_915234 0.30 ENSDART00000164816
cnr1
cannabinoid receptor 1
chr25_-_17403598 0.29 ENSDART00000104216
cyp2x9
cytochrome P450, family 2, subfamily X, polypeptide 9
chr25_+_32473433 0.29 ENSDART00000152326
sqor
sulfide quinone oxidoreductase
chr17_-_51202339 0.28 ENSDART00000167117
si:ch1073-469d17.2
si:ch1073-469d17.2
chr20_-_38610360 0.28 ENSDART00000168783
ENSDART00000164638
slc30a2
solute carrier family 30 (zinc transporter), member 2
chr16_+_20220225 0.27 ENSDART00000182208
colq
collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
chr18_+_22793743 0.27 ENSDART00000150106
gnao1a
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a
chr14_+_43554490 0.27 ENSDART00000060351
adra1bb
adrenoceptor alpha 1Bb
chr3_+_57991074 0.26 ENSDART00000076077
myadml2
myeloid-associated differentiation marker-like 2
chr25_+_32474031 0.25 ENSDART00000152124
sqor
sulfide quinone oxidoreductase
chr15_+_16525126 0.25 ENSDART00000193455
galnt17
polypeptide N-acetylgalactosaminyltransferase 17
chr25_+_245438 0.25 ENSDART00000004689
zgc:92481
zgc:92481
chr11_+_30314885 0.25 ENSDART00000187418
ENSDART00000123244
ugt1b2
UDP glucuronosyltransferase 1 family, polypeptide B2
chr10_-_15048781 0.25 ENSDART00000038401
ENSDART00000155674
si:ch211-95j8.2
si:ch211-95j8.2
chr1_-_17797802 0.24 ENSDART00000041215
sorbs2a
sorbin and SH3 domain containing 2a
chr4_+_4902392 0.23 ENSDART00000133866
ptprz1b
protein tyrosine phosphatase, receptor-type, Z polypeptide 1b
chr14_-_29859067 0.19 ENSDART00000136380
sorbs2b
sorbin and SH3 domain containing 2b
chr18_-_17485419 0.19 ENSDART00000018764
foxl1
forkhead box L1
chr25_+_22730490 0.18 ENSDART00000149455
abcc8
ATP-binding cassette, sub-family C (CFTR/MRP), member 8
chr7_+_34790768 0.18 ENSDART00000075116
si:dkey-148a17.6
si:dkey-148a17.6
chr18_+_9641210 0.17 ENSDART00000182024
pclob
piccolo presynaptic cytomatrix protein b
chr24_-_25184553 0.17 ENSDART00000166917
plcxd2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr4_-_43822179 0.17 ENSDART00000185246
si:dkey-261p22.1
si:dkey-261p22.1
chr12_-_46145635 0.17 ENSDART00000074682
zgc:153932
zgc:153932
chr5_-_58112032 0.17 ENSDART00000016418
drd2b
dopamine receptor D2b
chr24_+_7828613 0.15 ENSDART00000135161
zgc:101569
zgc:101569
chr23_-_27875140 0.15 ENSDART00000143662
ankrd33aa
ankyrin repeat domain 33Aa
chr8_-_49201258 0.15 ENSDART00000114584
ENSDART00000142172
zgc:171501
zgc:171501
chr13_+_12396316 0.14 ENSDART00000143557
atp10d
ATPase phospholipid transporting 10D
chr8_-_40075983 0.14 ENSDART00000141455
ggt1a
gamma-glutamyltransferase 1a
chr24_-_6258869 0.14 ENSDART00000006636
ENSDART00000178667
myo3a
myosin IIIA
chr20_+_10498704 0.13 ENSDART00000192985
zgc:100997
zgc:100997
chr3_+_23692462 0.13 ENSDART00000145934
hoxb7a
homeobox B7a
chr16_-_4836218 0.13 ENSDART00000054077
tpbgb
trophoblast glycoprotein b
chr6_-_8480815 0.13 ENSDART00000162300
rasal3
RAS protein activator like 3
chr10_+_40235959 0.12 ENSDART00000145862
gramd1ba
GRAM domain containing 1Ba
chr21_-_30415524 0.12 ENSDART00000101036
grpel2
GrpE-like 2, mitochondrial
chr5_+_20437124 0.12 ENSDART00000159001
tmem119a
transmembrane protein 119a
chr25_-_27722614 0.12 ENSDART00000190154
zgc:153935
zgc:153935
chr21_-_30935262 0.12 ENSDART00000172390
stim1b
stromal interaction molecule 1b
chr23_+_12072980 0.11 ENSDART00000141646
edn3b
endothelin 3b
chr13_-_45201300 0.10 ENSDART00000074750
ENSDART00000180265
runx3
runt-related transcription factor 3
chr21_+_29227224 0.10 ENSDART00000013641
adra1ba
adrenoceptor alpha 1Ba
chr13_+_31583034 0.10 ENSDART00000111763
six6a
SIX homeobox 6a
chr23_+_21424747 0.10 ENSDART00000135440
ENSDART00000104214
tas1r1
taste receptor, type 1, member 1
chr20_+_40457599 0.09 ENSDART00000017553
serinc1
serine incorporator 1
chr17_+_6563307 0.09 ENSDART00000156454
adgrf3a
adhesion G protein-coupled receptor F3a
chr4_-_17741513 0.09 ENSDART00000141680
mybpc1
myosin binding protein C, slow type
chr21_-_38619305 0.09 ENSDART00000139178
slc25a14
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr4_-_38476901 0.08 ENSDART00000167124
si:ch211-209n20.59
si:ch211-209n20.59
chr3_-_19091024 0.08 ENSDART00000188485
ENSDART00000110554
grin2ca
glutamate receptor, ionotropic, N-methyl D-aspartate 2Ca
chr18_+_33100606 0.08 ENSDART00000003907
si:ch211-229c8.13
si:ch211-229c8.13
chr21_+_27340682 0.06 ENSDART00000011305
dpp3
dipeptidyl-peptidase 3
chr2_-_30784198 0.06 ENSDART00000182523
ENSDART00000147355
rgs20
regulator of G protein signaling 20
chr5_-_25621386 0.06 ENSDART00000051565
cyp1d1
cytochrome P450, family 1, subfamily D, polypeptide 1
chr20_-_25626693 0.06 ENSDART00000132247
paics
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr8_+_28467893 0.06 ENSDART00000189724
slc52a3
solute carrier family 52 (riboflavin transporter), member 3
chr23_+_4414164 0.05 ENSDART00000192762
wnt7ab
wingless-type MMTV integration site family, member 7Ab
chr9_-_11655031 0.05 ENSDART00000044314
itgav
integrin, alpha V
chr7_+_51816321 0.05 ENSDART00000073846
si:ch211-122f10.4
si:ch211-122f10.4
chr22_-_188102 0.05 ENSDART00000125391
ENSDART00000170463
CABZ01052268.1

chr23_+_4414343 0.04 ENSDART00000081821
wnt7ab
wingless-type MMTV integration site family, member 7Ab
chr2_+_48638827 0.03 ENSDART00000163634
CR381673.2

chr18_+_3022188 0.03 ENSDART00000170004
CU570791.1

chr19_-_10631482 0.03 ENSDART00000129264
si:dkey-211g8.9
si:dkey-211g8.9
chr3_+_5083407 0.03 ENSDART00000146883
si:ch73-338o16.4
si:ch73-338o16.4
chr6_-_43817761 0.03 ENSDART00000183945
foxp1b
forkhead box P1b
chr10_-_36726188 0.03 ENSDART00000157262
pimr137
Pim proto-oncogene, serine/threonine kinase, related 137
chr14_+_46020282 0.02 ENSDART00000190087
c1qtnf2
C1q and TNF related 2
chr18_+_9635178 0.02 ENSDART00000183486
pclob
piccolo presynaptic cytomatrix protein b
chr19_+_2546775 0.02 ENSDART00000148527
ENSDART00000097528
sp4
sp4 transcription factor
chr23_-_14057191 0.01 ENSDART00000154908
adcy6a
adenylate cyclase 6a
chr20_-_35052464 0.01 ENSDART00000037195
kif26bb
kinesin family member 26Bb
chr16_-_21047872 0.00 ENSDART00000131582
cbx3b
chromobox homolog 3b
chr16_-_4026265 0.00 ENSDART00000149339
si:ch211-175f12.2
si:ch211-175f12.2
chr23_-_41824460 0.00 ENSDART00000131235
GMEB2
si:ch73-302a13.2
chr18_+_2585298 0.00 ENSDART00000166314
ENSDART00000162043
p2ry2.2
purinergic receptor P2Y2, tandem duplicate 2

Network of associatons between targets according to the STRING database.

First level regulatory network of gli2a+gli3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0060155 secretory granule organization(GO:0033363) platelet dense granule organization(GO:0060155)
0.2 0.7 GO:0034035 sulfate assimilation(GO:0000103) purine ribonucleoside bisphosphate metabolic process(GO:0034035) purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428)
0.2 0.7 GO:0009229 thiamine diphosphate biosynthetic process(GO:0009229)
0.2 1.7 GO:0048635 negative regulation of muscle organ development(GO:0048635)
0.2 0.5 GO:0070221 sulfide oxidation(GO:0019418) sulfide oxidation, using sulfide:quinone oxidoreductase(GO:0070221)
0.2 0.5 GO:0021530 spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.2 0.5 GO:2000471 regulation of hematopoietic stem cell migration(GO:2000471)
0.1 2.6 GO:0014823 response to activity(GO:0014823)
0.1 0.4 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.1 2.7 GO:0015671 oxygen transport(GO:0015671)
0.1 1.1 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.1 1.1 GO:0031268 pseudopodium organization(GO:0031268) pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.1 0.4 GO:0090113 regulation of COPII vesicle coating(GO:0003400) regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis(GO:0090113)
0.1 0.9 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.1 1.2 GO:0006603 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.1 0.5 GO:1901739 regulation of myoblast fusion(GO:1901739)
0.1 0.3 GO:0061088 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.1 1.1 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.1 1.5 GO:0043171 peptide catabolic process(GO:0043171)
0.1 0.6 GO:0097009 energy homeostasis(GO:0097009)
0.1 0.4 GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996) positive regulation of blood pressure by epinephrine-norepinephrine(GO:0003321) positive regulation of heart rate(GO:0010460)
0.1 0.9 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208)
0.0 1.0 GO:0045773 positive regulation of axon extension(GO:0045773)
0.0 0.7 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.0 0.6 GO:0051597 response to methylmercury(GO:0051597)
0.0 0.8 GO:0097178 ruffle assembly(GO:0097178)
0.0 0.9 GO:0006825 copper ion transport(GO:0006825)
0.0 0.1 GO:0033690 positive regulation of osteoblast proliferation(GO:0033690)
0.0 0.3 GO:0038171 cannabinoid signaling pathway(GO:0038171) positive regulation of feeding behavior(GO:2000253)
0.0 0.5 GO:0030325 adrenal gland development(GO:0030325)
0.0 1.4 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.6 GO:0045807 positive regulation of endocytosis(GO:0045807)
0.0 0.7 GO:0060291 long-term synaptic potentiation(GO:0060291)
0.0 0.1 GO:0003100 regulation of systemic arterial blood pressure by endothelin(GO:0003100) vein smooth muscle contraction(GO:0014826) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0 0.2 GO:1904071 presynaptic active zone assembly(GO:1904071)
0.0 0.1 GO:0015729 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) succinate transport(GO:0015744) succinate transmembrane transport(GO:0071422) malate transmembrane transport(GO:0071423)
0.0 2.2 GO:0042742 defense response to bacterium(GO:0042742)
0.0 0.1 GO:0032237 activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 0.7 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.0 0.4 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 1.4 GO:0099643 neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643)
0.0 0.1 GO:0090245 axis elongation involved in somitogenesis(GO:0090245)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.7 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 2.2 GO:0046930 pore complex(GO:0046930)
0.1 1.0 GO:0044295 axonal growth cone(GO:0044295)
0.1 2.6 GO:0005861 troponin complex(GO:0005861)
0.1 0.9 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.6 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.1 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.0 2.1 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 0.5 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 0.4 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.4 GO:0043195 terminal bouton(GO:0043195)
0.0 0.2 GO:0098982 GABA-ergic synapse(GO:0098982)
0.0 1.1 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.4 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 1.0 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.2 GO:0030267 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.7 2.2 GO:0048030 disaccharide binding(GO:0048030)
0.4 1.7 GO:0097108 hedgehog family protein binding(GO:0097108)
0.2 0.7 GO:0004020 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.2 0.7 GO:0030975 thiamine diphosphokinase activity(GO:0004788) thiamine binding(GO:0030975)
0.2 2.7 GO:0031720 haptoglobin binding(GO:0031720)
0.2 1.0 GO:0008046 axon guidance receptor activity(GO:0008046)
0.2 0.5 GO:0070224 sulfide:quinone oxidoreductase activity(GO:0070224)
0.2 0.5 GO:0047291 lactosylceramide alpha-2,3-sialyltransferase activity(GO:0047291)
0.2 0.6 GO:0031782 type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.1 0.8 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.1 1.0 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.1 1.1 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.1 1.2 GO:0004111 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.1 2.6 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 0.9 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.1 0.9 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.1 0.3 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.1 1.1 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 0.3 GO:0051430 mu-type opioid receptor binding(GO:0031852) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0 0.4 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.0 1.4 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.5 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.2 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.0 1.4 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.5 GO:0042056 chemoattractant activity(GO:0042056)
0.0 0.1 GO:0000048 peptidyltransferase activity(GO:0000048) glutathione hydrolase activity(GO:0036374)
0.0 0.1 GO:0031708 endothelin B receptor binding(GO:0031708)
0.0 0.1 GO:0050649 testosterone 6-beta-hydroxylase activity(GO:0050649)
0.0 0.5 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.4 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.1 GO:0015131 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131) malate transmembrane transporter activity(GO:0015140)
0.0 0.4 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.3 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.6 GO:0005518 collagen binding(GO:0005518)
0.0 0.7 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.1 GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity(GO:0004639)
0.0 0.2 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.2 GO:0098882 structural constituent of presynaptic active zone(GO:0098882)
0.0 0.7 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.1 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.1 0.6 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 1.1 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.6 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.3 PID NCADHERIN PATHWAY N-cadherin signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.1 2.7 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 1.4 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.1 0.6 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 1.7 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.7 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.2 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.0 0.1 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)