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PRJNA195909:zebrafish embryo and larva development

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Results for glis3

Z-value: 0.56

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Transcription factors associated with glis3

Gene Symbol Gene ID Gene Info
glis3
ENSDARG00000069726 GLIS family zinc finger 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
glis3dr11_v1_chr10_-_690072_6901700.713.4e-02Click!

Activity profile of glis3 motif

Sorted Z-values of glis3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_30704075 1.51 ENSDART00000134098
efemp2a
EGF containing fibulin extracellular matrix protein 2a
chr15_-_41245962 1.11 ENSDART00000155359
smco4
single-pass membrane protein with coiled-coil domains 4
chr5_+_45000597 0.77 ENSDART00000051146
dmrt3a
doublesex and mab-3 related transcription factor 3a
chr14_-_34044369 0.69 ENSDART00000149396
ENSDART00000123607
ENSDART00000190746
cyfip2
cytoplasmic FMR1 interacting protein 2
chr18_-_41375120 0.69 ENSDART00000098673
ptx3a
pentraxin 3, long a
chr8_-_15182232 0.68 ENSDART00000138855
bcar3
BCAR3, NSP family adaptor protein
chr5_+_67662430 0.56 ENSDART00000137700
ENSDART00000142586
si:dkey-70b23.2
si:dkey-70b23.2
chr8_+_46641314 0.55 ENSDART00000113803
her3
hairy-related 3
chr25_+_7461624 0.53 ENSDART00000170569
syt12
synaptotagmin XII
chr22_-_3261879 0.47 ENSDART00000159643
gpr35.1
G protein-coupled receptor 35, tandem duplicate 1
chr17_+_8925232 0.44 ENSDART00000036668
psmc1a
proteasome 26S subunit, ATPase 1a
chr20_-_18915376 0.44 ENSDART00000063725
xkr6b
XK, Kell blood group complex subunit-related family, member 6b
chr13_-_638485 0.33 ENSDART00000066080
ENSDART00000128969
slit1a
slit homolog 1a (Drosophila)
chr17_+_23578316 0.32 ENSDART00000149281
slc16a12a
solute carrier family 16, member 12a
chr20_-_9963713 0.31 ENSDART00000104234
gjd2b
gap junction protein delta 2b
chr21_+_20949976 0.26 ENSDART00000135342
htr1ab
5-hydroxytryptamine (serotonin) receptor 1A b
chr3_-_25106878 0.25 ENSDART00000142503
rbx1
ring-box 1, E3 ubiquitin protein ligase
chr21_+_20950161 0.20 ENSDART00000079698
htr1ab
5-hydroxytryptamine (serotonin) receptor 1A b
chr10_+_29260096 0.20 ENSDART00000088973
sytl2a
synaptotagmin-like 2a
chr24_-_38574631 0.17 ENSDART00000154539
slc17a7b
solute carrier family 17 (vesicular glutamate transporter), member 7b
chr18_+_33100606 0.04 ENSDART00000003907
si:ch211-229c8.13
si:ch211-229c8.13

Network of associatons between targets according to the STRING database.

First level regulatory network of glis3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 0.8 GO:0046661 male sex differentiation(GO:0046661)
0.0 0.7 GO:0001964 startle response(GO:0001964)
0.0 0.4 GO:0070782 phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.0 0.7 GO:0033138 positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.0 0.5 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.0 0.2 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.0 0.5 GO:0060291 long-term synaptic potentiation(GO:0060291)
0.0 0.3 GO:0045773 positive regulation of axon extension(GO:0045773)
0.0 0.5 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 GO:0031209 SCAR complex(GO:0031209)
0.0 0.4 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.3 GO:0005922 connexon complex(GO:0005922)
0.0 0.2 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.1 0.3 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.0 0.7 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.3 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.5 GO:0051378 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 0.7 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.2 GO:0005326 neurotransmitter transporter activity(GO:0005326)
0.0 0.2 GO:0097602 cullin family protein binding(GO:0097602)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.7 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.2 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling