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PRJNA195909:zebrafish embryo and larva development

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Results for gmeb2

Z-value: 0.72

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Transcription factors associated with gmeb2

Gene Symbol Gene ID Gene Info
gmeb2
ENSDARG00000093240 si_ch73-302a13.2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GMEB2dr11_v1_chr23_-_41824460_418244600.915.8e-04Click!

Activity profile of gmeb2 motif

Sorted Z-values of gmeb2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_29910547 1.53 ENSDART00000151501
RUNDC1
si:dkey-151m15.5
chr17_-_51818659 1.22 ENSDART00000111389
ENSDART00000157244
exd2
exonuclease 3'-5' domain containing 2
chr24_+_34069675 1.21 ENSDART00000143995
si:ch211-190p8.2
si:ch211-190p8.2
chr1_-_49521407 1.20 ENSDART00000189845
ENSDART00000143474
zp3c
zona pellucida glycoprotein 3c
chr15_-_20412286 1.13 ENSDART00000008589
chp2
calcineurin-like EF-hand protein 2
chr17_-_36860988 1.06 ENSDART00000154981
senp6b
SUMO1/sentrin specific peptidase 6b
chr2_-_17114852 1.05 ENSDART00000006549
pif1
PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae)
chr2_-_17115256 1.04 ENSDART00000190488
pif1
PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae)
chr13_+_40501455 0.99 ENSDART00000114985
hpse2
heparanase 2
chr18_-_20674121 0.96 ENSDART00000005145
asz1
ankyrin repeat, SAM and basic leucine zipper domain containing 1
chr15_+_5116179 0.92 ENSDART00000101937
pgm2l1
phosphoglucomutase 2-like 1
chr13_+_42309688 0.91 ENSDART00000158367
ide
insulin-degrading enzyme
chr17_-_25831569 0.83 ENSDART00000148743
hhat
hedgehog acyltransferase
chr21_+_18405585 0.83 ENSDART00000139318
si:dkey-1d7.3
si:dkey-1d7.3
chr8_-_38022298 0.79 ENSDART00000067809
rab11fip1a
RAB11 family interacting protein 1 (class I) a
chr3_-_46410387 0.78 ENSDART00000156822
cdip1
cell death-inducing p53 target 1
chr7_-_37895771 0.77 ENSDART00000084282
papd5
PAP associated domain containing 5
chr19_+_19241372 0.76 ENSDART00000184392
ENSDART00000165008
ptpn23b
protein tyrosine phosphatase, non-receptor type 23, b
chr11_+_11120532 0.75 ENSDART00000026135
ENSDART00000189872
ly75
lymphocyte antigen 75
chr7_+_13824150 0.71 ENSDART00000035067
abhd2a
abhydrolase domain containing 2a
chr20_-_44576949 0.68 ENSDART00000148639
ubxn2a
UBX domain protein 2A
chr24_+_37484661 0.66 ENSDART00000165125
ENSDART00000109221
wdr90
WD repeat domain 90
chr21_+_1647990 0.65 ENSDART00000148540
fech
ferrochelatase
chr3_+_53156813 0.65 ENSDART00000114343
brd4
bromodomain containing 4
chr2_-_21170517 0.64 ENSDART00000135417
bmi1b
bmi1 polycomb ring finger oncogene 1b
chr3_+_32789605 0.63 ENSDART00000171895
tbc1d10b
TBC1 domain family, member 10b
chr10_+_16501699 0.61 ENSDART00000121864
slc27a6
solute carrier family 27 (fatty acid transporter), member 6
chr20_-_31743553 0.60 ENSDART00000087405
sash1a
SAM and SH3 domain containing 1a
chr7_+_13382852 0.59 ENSDART00000166318
dagla
diacylglycerol lipase, alpha
chr1_+_23274710 0.59 ENSDART00000036448
lias
lipoic acid synthetase
chr4_+_9011825 0.59 ENSDART00000058007
samm50l
sorting and assembly machinery component 50 homolog, like
chr10_+_6884123 0.58 ENSDART00000149095
ENSDART00000148772
ENSDART00000149334
ddx4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
chr21_-_33995710 0.56 ENSDART00000100508
ENSDART00000179622
ebf1b
early B cell factor 1b
chr8_+_30112655 0.56 ENSDART00000099027
fancc
Fanconi anemia, complementation group C
chr12_+_17603528 0.56 ENSDART00000111565
pms2
PMS1 homolog 2, mismatch repair system component
chr17_-_12058171 0.55 ENSDART00000105236
smyd3
SET and MYND domain containing 3
chr19_+_46259619 0.54 ENSDART00000158032
grinaa
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1a (glutamate binding)
chr3_+_22335030 0.54 ENSDART00000055676
zgc:103564
zgc:103564
chr5_-_69944084 0.53 ENSDART00000188557
ENSDART00000127782
ugt2a4
UDP glucuronosyltransferase 2 family, polypeptide A4
chr21_+_6397463 0.53 ENSDART00000136539
si:ch211-225g23.1
si:ch211-225g23.1
chr22_-_817479 0.52 ENSDART00000123487
zgc:153675
zgc:153675
chr5_-_13076779 0.52 ENSDART00000192826
ypel1
yippee-like 1
chr14_-_22495604 0.52 ENSDART00000137167
si:ch211-107m4.1
si:ch211-107m4.1
chr5_-_54395488 0.51 ENSDART00000160781
zmynd19
zinc finger, MYND-type containing 19
chr19_-_432083 0.51 ENSDART00000165371
dus3l
dihydrouridine synthase 3-like (S. cerevisiae)
chr13_-_36680531 0.51 ENSDART00000085298
l2hgdh
L-2-hydroxyglutarate dehydrogenase
chr3_-_11089062 0.50 ENSDART00000168938
mif4gdb
MIF4G domain containing b
chr20_+_25486021 0.49 ENSDART00000063052
hook1
hook microtubule-tethering protein 1
chr2_-_54387550 0.49 ENSDART00000097388
napgb
N-ethylmaleimide-sensitive factor attachment protein, gamma b
chr6_-_60079551 0.48 ENSDART00000154753
pmepa1
prostate transmembrane protein, androgen induced 1
chr18_-_14879135 0.48 ENSDART00000099701
selenoo1
selenoprotein O1
chr10_-_16868211 0.48 ENSDART00000171755
stoml2
stomatin (EPB72)-like 2
chr23_+_17522867 0.48 ENSDART00000002714
slc17a9b
solute carrier family 17 (vesicular nucleotide transporter), member 9b
chr4_+_9011448 0.47 ENSDART00000192357
samm50l
sorting and assembly machinery component 50 homolog, like
chr23_-_35790235 0.47 ENSDART00000142369
ENSDART00000141141
ENSDART00000011004
mfsd5
major facilitator superfamily domain containing 5
chr20_-_32405440 0.46 ENSDART00000062978
ENSDART00000153411
afg1lb
AFG1 like ATPase b
chr11_-_18799827 0.45 ENSDART00000185438
ENSDART00000189116
ENSDART00000180504
pfkfb2b
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2b
chr23_-_33738570 0.45 ENSDART00000131680
si:ch211-210c8.7
si:ch211-210c8.7
chr9_-_4598883 0.44 ENSDART00000171927
galnt13
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13
chr12_+_11650146 0.44 ENSDART00000150191
waplb
WAPL cohesin release factor b
chr7_+_69528850 0.44 ENSDART00000109507
RAP1GDS1
Rap1 GTPase-GDP dissociation stimulator 1
chr23_-_33558161 0.43 ENSDART00000018301
itga5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr6_-_24053404 0.42 ENSDART00000168511
si:dkey-44g17.6
si:dkey-44g17.6
chr8_-_5267442 0.42 ENSDART00000155816
ppp2r2aa
protein phosphatase 2, regulatory subunit B, alpha a
chr20_-_37933237 0.42 ENSDART00000142567
ENSDART00000036371
ENSDART00000061445
angel2
angel homolog 2 (Drosophila)
chr12_+_28956374 0.41 ENSDART00000033878
znf668
zinc finger protein 668
chr10_+_43088270 0.41 ENSDART00000191221
xrcc4
X-ray repair complementing defective repair in Chinese hamster cells 4
chr5_-_51198430 0.41 ENSDART00000132503
ENSDART00000097473
ENSDART00000165870
snapc4
small nuclear RNA activating complex, polypeptide 4
chr10_+_29137482 0.41 ENSDART00000178280
picalma
phosphatidylinositol binding clathrin assembly protein a
chr8_-_32354677 0.41 ENSDART00000138268
ENSDART00000133245
ENSDART00000179677
ENSDART00000174450
ipo11
importin 11
chr10_-_41352502 0.41 ENSDART00000052971
ENSDART00000128156
rab11fip1b
RAB11 family interacting protein 1 (class I) b
chr5_+_57210237 0.40 ENSDART00000167660
pja2
praja ring finger ubiquitin ligase 2
chr23_+_2703044 0.39 ENSDART00000182512
ENSDART00000105286
ncoa6
nuclear receptor coactivator 6
chr7_+_52761841 0.39 ENSDART00000111444
ppip5k1a
diphosphoinositol pentakisphosphate kinase 1a
chr5_+_26138313 0.39 ENSDART00000010041
dhfr
dihydrofolate reductase
chr10_+_29138021 0.39 ENSDART00000025227
ENSDART00000123033
ENSDART00000034242
picalma
phosphatidylinositol binding clathrin assembly protein a
chr22_-_547748 0.38 ENSDART00000037455
ENSDART00000140101
ccnd3
cyclin D3
chr21_-_44772738 0.38 ENSDART00000026178
kif4
kinesin family member 4
chr10_-_21941443 0.38 ENSDART00000174954
FO744833.1

chr12_-_9132682 0.38 ENSDART00000066471
adam8b
ADAM metallopeptidase domain 8b
chr8_-_19467011 0.37 ENSDART00000162010
zgc:92140
zgc:92140
chr14_+_10625112 0.37 ENSDART00000143377
ENSDART00000136480
nup62l
nucleoporin 62 like
chr18_+_5917625 0.36 ENSDART00000169100
glg1b
golgi glycoprotein 1b
chr23_-_33738945 0.36 ENSDART00000136386
si:ch211-210c8.7
si:ch211-210c8.7
chr15_-_11683529 0.36 ENSDART00000161445
fkrp
fukutin related protein
chr25_+_21098675 0.35 ENSDART00000079012
rad52
RAD52 homolog, DNA repair protein
chr13_+_36680564 0.35 ENSDART00000136030
ENSDART00000006923
atp5s
ATP synthase, H+ transporting, mitochondrial F0 complex subunit s
chr3_-_13146631 0.35 ENSDART00000172460
prkar1b
protein kinase, cAMP-dependent, regulatory, type I, beta
chr8_-_1219815 0.35 ENSDART00000016800
ENSDART00000149969
znf367
zinc finger protein 367
chr20_+_25486206 0.35 ENSDART00000172076
hook1
hook microtubule-tethering protein 1
chr14_+_8947282 0.35 ENSDART00000047993
rps6kal
ribosomal protein S6 kinase a, like
chr14_-_8890437 0.34 ENSDART00000167242
ATG2A
si:ch73-45o6.2
chr9_+_25840720 0.34 ENSDART00000024572
gtdc1
glycosyltransferase-like domain containing 1
chr25_+_36045072 0.34 ENSDART00000126326
rpgrip1l
RPGRIP1-like
chr7_+_51795667 0.33 ENSDART00000174201
ENSDART00000073839
slc38a7
solute carrier family 38, member 7
chr13_+_30035253 0.33 ENSDART00000181303
ENSDART00000057525
ENSDART00000136622
dnajb12a
DnaJ (Hsp40) homolog, subfamily B, member 12a
chr7_+_55292959 0.33 ENSDART00000147539
ENSDART00000073555
ctu2
cytosolic thiouridylase subunit 2 homolog (S. pombe)
chr19_-_20163197 0.32 ENSDART00000148179
ENSDART00000151646
fam221a
family with sequence similarity 221, member A
chr13_+_2442841 0.32 ENSDART00000114456
ENSDART00000137124
ENSDART00000193737
ENSDART00000189722
ENSDART00000187485
arfgef3
ARFGEF family member 3
chr17_-_6076266 0.32 ENSDART00000171084
ephx2
epoxide hydrolase 2, cytoplasmic
chr2_+_38055529 0.32 ENSDART00000145642
si:rp71-1g18.1
si:rp71-1g18.1
chr12_+_33460794 0.32 ENSDART00000007053
ENSDART00000142716
narf
nuclear prelamin A recognition factor
chr1_+_52662203 0.31 ENSDART00000141530
osbp
oxysterol binding protein
chr20_-_31743817 0.31 ENSDART00000137679
sash1a
SAM and SH3 domain containing 1a
chr16_+_40131473 0.30 ENSDART00000155421
ENSDART00000134732
ENSDART00000138699
cenpw
si:ch211-195p4.4
centromere protein W
si:ch211-195p4.4
chr25_+_21098990 0.30 ENSDART00000017488
rad52
RAD52 homolog, DNA repair protein
chr6_-_37745508 0.30 ENSDART00000078316
nipa2
non imprinted in Prader-Willi/Angelman syndrome 2 (human)
chr9_+_12948511 0.29 ENSDART00000135797
si:dkey-230p4.1
si:dkey-230p4.1
chr3_+_46764278 0.29 ENSDART00000136051
ENSDART00000164930
prkcsh
protein kinase C substrate 80K-H
chr7_-_38570878 0.29 ENSDART00000139187
ENSDART00000134570
ENSDART00000041055
celf1
cugbp, Elav-like family member 1
chr17_-_31611692 0.29 ENSDART00000141480
si:dkey-170l10.1
si:dkey-170l10.1
chr1_+_26105141 0.29 ENSDART00000102379
ENSDART00000127154
toporsa
topoisomerase I binding, arginine/serine-rich a
chr8_+_47897734 0.29 ENSDART00000140266
mfn2
mitofusin 2
chr3_+_32933663 0.29 ENSDART00000112742
nbr1b
neighbor of brca1 gene 1b
chr5_-_24245218 0.29 ENSDART00000042481
phf23a
PHD finger protein 23a
chr3_-_13147310 0.29 ENSDART00000160840
prkar1b
protein kinase, cAMP-dependent, regulatory, type I, beta
chr8_+_13064750 0.28 ENSDART00000039878
sap30bp
SAP30 binding protein
chr24_+_5208171 0.28 ENSDART00000155926
ENSDART00000154464
si:ch73-206p6.1
si:ch73-206p6.1
chr12_-_27588299 0.28 ENSDART00000178023
ENSDART00000066282
dhx8
DEAH (Asp-Glu-Ala-His) box polypeptide 8
chr25_-_21066136 0.27 ENSDART00000109520
fbxl14a
F-box and leucine-rich repeat protein 14a
chr17_-_6076084 0.26 ENSDART00000058890
ephx2
epoxide hydrolase 2, cytoplasmic
chr3_-_30186296 0.26 ENSDART00000134395
ENSDART00000077057
ENSDART00000017422
tbc1d17
TBC1 domain family, member 17
chr7_+_66634167 0.25 ENSDART00000027616
eif4g2a
eukaryotic translation initiation factor 4, gamma 2a
chr2_+_10821127 0.25 ENSDART00000145770
ENSDART00000174629
ENSDART00000081094
glmna
glomulin, FKBP associated protein a
chr2_+_10821579 0.23 ENSDART00000179694
glmna
glomulin, FKBP associated protein a
chr1_-_31516091 0.23 ENSDART00000139828
ENSDART00000146567
cenpk
centromere protein K
chr1_+_49415281 0.23 ENSDART00000015007
taf5
TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr16_-_47427016 0.23 ENSDART00000074575
sept7b
septin 7b
chr13_+_21676235 0.23 ENSDART00000137804
ENSDART00000134950
ENSDART00000129653
mtg1
mitochondrial ribosome-associated GTPase 1
chr17_-_37195163 0.23 ENSDART00000108514
asxl2
additional sex combs like transcriptional regulator 2
chr15_+_32798333 0.23 ENSDART00000162370
ENSDART00000166525
spartb
spartin b
chr12_+_20552190 0.23 ENSDART00000113224
gna13a
guanine nucleotide binding protein (G protein), alpha 13a
chr7_-_39751540 0.23 ENSDART00000016803
grpel1
GrpE-like 1, mitochondrial
chr18_+_49248389 0.22 ENSDART00000059285
ENSDART00000142004
ENSDART00000132751
yif1b
Yip1 interacting factor homolog B (S. cerevisiae)
chr6_-_39903393 0.22 ENSDART00000085945
tsfm
Ts translation elongation factor, mitochondrial
chr23_-_4975452 0.22 ENSDART00000105241
ENSDART00000169978
ngfa
nerve growth factor a (beta polypeptide)
chr2_-_3403020 0.22 ENSDART00000092741
snap47
synaptosomal-associated protein, 47
chr25_-_17494364 0.22 ENSDART00000154134
lrrc29
leucine rich repeat containing 29
chr24_-_7826489 0.21 ENSDART00000112777
si:dkey-197c15.6
si:dkey-197c15.6
chr8_+_20455134 0.21 ENSDART00000079618
rexo1
REX1, RNA exonuclease 1 homolog
chr17_-_43399896 0.21 ENSDART00000156033
ENSDART00000156418
itpk1b
inositol-tetrakisphosphate 1-kinase b
chr25_-_2723682 0.21 ENSDART00000113382
adpgk
ADP-dependent glucokinase
chr20_+_38837238 0.20 ENSDART00000061334
ift172
intraflagellar transport 172
chr22_-_22301672 0.20 ENSDART00000111711
chaf1a
chromatin assembly factor 1, subunit A (p150)
chr2_+_54387710 0.19 ENSDART00000127124
rab12
RAB12, member RAS oncogene family
chr3_+_46764022 0.19 ENSDART00000023814
prkcsh
protein kinase C substrate 80K-H
chr14_-_21932403 0.19 ENSDART00000054420
rad9a
RAD9 checkpoint clamp component A
chr4_+_23126558 0.19 ENSDART00000162859
mdm2
MDM2 oncogene, E3 ubiquitin protein ligase
chr2_-_32826108 0.18 ENSDART00000098834
prpf4ba
pre-mRNA processing factor 4Ba
chr25_-_6389713 0.18 ENSDART00000083539
sin3aa
SIN3 transcription regulator family member Aa
chr2_+_52049239 0.18 ENSDART00000036813
ccdc94
coiled-coil domain containing 94
chr6_-_40455109 0.18 ENSDART00000103878
vhl
von Hippel-Lindau tumor suppressor
chr15_-_23692359 0.18 ENSDART00000141618
ercc2
excision repair cross-complementation group 2
chr22_-_22301929 0.18 ENSDART00000142027
chaf1a
chromatin assembly factor 1, subunit A (p150)
chr15_-_43284021 0.18 ENSDART00000041677
serpine2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr3_-_8765165 0.17 ENSDART00000191131
CABZ01058333.1

chr5_-_67365006 0.17 ENSDART00000136116
unga
uracil DNA glycosylase a
chr5_-_6567464 0.16 ENSDART00000184985
tnks1bp1
tankyrase 1 binding protein 1
chr2_+_32826235 0.16 ENSDART00000143127
si:dkey-154p10.3
si:dkey-154p10.3
chr2_-_32486080 0.16 ENSDART00000110821
ttc19
tetratricopeptide repeat domain 19
chr19_-_35155722 0.16 ENSDART00000151924
macf1a
microtubule-actin crosslinking factor 1a
chr16_-_33817828 0.16 ENSDART00000188395
rspo1
R-spondin 1
chr9_+_19529951 0.15 ENSDART00000125416
pknox1.1
pbx/knotted 1 homeobox 1.1
chr13_+_36923052 0.15 ENSDART00000026313
tmx1
thioredoxin-related transmembrane protein 1
chr9_-_7655243 0.15 ENSDART00000102706
dnajb2
DnaJ (Hsp40) homolog, subfamily B, member 2
chr17_-_49407091 0.15 ENSDART00000021950
mthfd1b
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b
chr2_+_2168547 0.14 ENSDART00000029347
higd1a
HIG1 hypoxia inducible domain family, member 1A
chr10_+_28428222 0.14 ENSDART00000135003
si:ch211-222e20.4
si:ch211-222e20.4
chr11_+_29770966 0.13 ENSDART00000088624
ENSDART00000124471
rpgrb
retinitis pigmentosa GTPase regulator b
chr5_-_29238889 0.13 ENSDART00000143098
si:dkey-61l1.4
si:dkey-61l1.4
chr21_-_11856143 0.13 ENSDART00000151204
ube2r2
ubiquitin-conjugating enzyme E2R 2
chr6_+_9163007 0.13 ENSDART00000183054
ENSDART00000157552
zgc:112023
zgc:112023
chr25_-_28668776 0.13 ENSDART00000126490
fnbp4
formin binding protein 4
chr3_+_46763745 0.12 ENSDART00000185437
prkcsh
protein kinase C substrate 80K-H
chr9_+_24920677 0.12 ENSDART00000037025
slc39a10
solute carrier family 39 (zinc transporter), member 10
chr5_-_23596339 0.12 ENSDART00000024815
fam76b
family with sequence similarity 76, member B
chr6_-_51541488 0.12 ENSDART00000156336
si:dkey-6e2.2
si:dkey-6e2.2
chr22_+_8800432 0.11 ENSDART00000139940
si:dkey-182g1.6
si:dkey-182g1.6
chr8_+_23390844 0.11 ENSDART00000184556
si:dkey-16n15.6
si:dkey-16n15.6
chr2_+_56012016 0.10 ENSDART00000146160
ENSDART00000188702
loxl5b
lysyl oxidase-like 5b
chr13_-_293250 0.10 ENSDART00000138581
chs1
chitin synthase 1
chr20_-_9199721 0.10 ENSDART00000064140
ylpm1
YLP motif containing 1
chr8_-_4760723 0.10 ENSDART00000064201
cdc45
CDC45 cell division cycle 45 homolog (S. cerevisiae)
chr13_+_24584401 0.10 ENSDART00000057599
fuom
fucose mutarotase
chr8_+_53311965 0.09 ENSDART00000130104
gnb1a
guanine nucleotide binding protein (G protein), beta polypeptide 1a
chr10_-_15910974 0.09 ENSDART00000148169
pip5k1ba
phosphatidylinositol-4-phosphate 5-kinase, type I, beta a
chr21_-_11855828 0.09 ENSDART00000081666
ube2r2
ubiquitin-conjugating enzyme E2R 2
chr12_+_3571770 0.09 ENSDART00000164707
ENSDART00000189819
coa3a
cytochrome C oxidase assembly factor 3a
chr3_+_59880317 0.09 ENSDART00000166922
ENSDART00000108647
alyref
Aly/REF export factor
chr6_-_10728057 0.09 ENSDART00000002247
sp3b
Sp3b transcription factor
chr11_+_24298432 0.08 ENSDART00000138487
si:dkey-76p14.2
si:dkey-76p14.2
chr11_-_41132296 0.08 ENSDART00000162944
dnajc11b
DnaJ (Hsp40) homolog, subfamily C, member 11b
chr22_+_24214665 0.07 ENSDART00000163980
ENSDART00000167996
glrx2
glutaredoxin 2
chr13_+_3938526 0.07 ENSDART00000012759
yipf3
Yip1 domain family, member 3
chr6_-_17849786 0.07 ENSDART00000172709
rptor
regulatory associated protein of MTOR, complex 1
chr18_+_31410652 0.07 ENSDART00000098504
def8
differentially expressed in FDCP 8 homolog (mouse)
chr23_+_20640484 0.06 ENSDART00000054691
uba1
ubiquitin-like modifier activating enzyme 1
chr7_+_41313568 0.06 ENSDART00000016660
zgc:165532
zgc:165532
chr12_+_45238292 0.06 ENSDART00000057983
mrpl38
mitochondrial ribosomal protein L38
chr22_-_11493236 0.05 ENSDART00000002691
tspan7b
tetraspanin 7b

Network of associatons between targets according to the STRING database.

First level regulatory network of gmeb2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0045040 outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.3 1.1 GO:0090230 regulation of centromere complex assembly(GO:0090230) regulation of kinetochore assembly(GO:0090234)
0.2 0.7 GO:0045002 double-strand break repair via single-strand annealing(GO:0045002)
0.2 0.6 GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407)
0.2 2.1 GO:0000002 mitochondrial genome maintenance(GO:0000002)
0.1 0.6 GO:0098920 endocannabinoid signaling pathway(GO:0071926) retrograde trans-synaptic signaling by lipid(GO:0098920) retrograde trans-synaptic signaling by endocannabinoid(GO:0098921)
0.1 0.4 GO:0060623 regulation of chromosome condensation(GO:0060623)
0.1 0.7 GO:0051792 medium-chain fatty acid biosynthetic process(GO:0051792)
0.1 0.4 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 0.4 GO:0006266 DNA ligation(GO:0006266) DNA ligation involved in DNA repair(GO:0051103)
0.1 0.4 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.1 0.3 GO:0000390 spliceosomal complex disassembly(GO:0000390)
0.1 0.6 GO:0009249 protein lipoylation(GO:0009249)
0.1 0.9 GO:0050435 beta-amyloid metabolic process(GO:0050435)
0.1 0.2 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.1 0.3 GO:0061031 endodermal digestive tract morphogenesis(GO:0061031) pancreas morphogenesis(GO:0061113)
0.1 0.4 GO:0090245 axis elongation involved in somitogenesis(GO:0090245)
0.1 0.4 GO:0060049 regulation of protein glycosylation(GO:0060049)
0.1 1.2 GO:0007339 binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.1 0.2 GO:0032957 inositol trisphosphate metabolic process(GO:0032957)
0.1 0.3 GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:0006978) DNA damage response, signal transduction resulting in transcription(GO:0042772)
0.1 0.5 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.1 1.0 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.1 0.2 GO:0043576 respiratory gaseous exchange(GO:0007585) regulation of respiratory gaseous exchange(GO:0043576)
0.1 0.2 GO:0031584 activation of phospholipase D activity(GO:0031584) negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.1 0.8 GO:0098927 early endosome to late endosome transport(GO:0045022) vesicle-mediated transport between endosomal compartments(GO:0098927)
0.1 0.3 GO:0032447 tRNA wobble position uridine thiolation(GO:0002143) protein urmylation(GO:0032447)
0.1 0.4 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.1 1.0 GO:0034587 piRNA metabolic process(GO:0034587)
0.0 0.5 GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902108)
0.0 0.6 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.0 0.5 GO:0051382 kinetochore assembly(GO:0051382)
0.0 0.5 GO:0046548 retinal rod cell development(GO:0046548)
0.0 0.4 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.0 0.3 GO:0048660 regulation of smooth muscle cell proliferation(GO:0048660) negative regulation of smooth muscle cell proliferation(GO:0048662)
0.0 0.3 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
0.0 0.1 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.0 0.7 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.0 0.4 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.2 GO:0097510 base-excision repair, AP site formation via deaminated base removal(GO:0097510)
0.0 0.2 GO:1904036 negative regulation of epithelial cell apoptotic process(GO:1904036)
0.0 0.1 GO:0070131 regulation of mitochondrial translation(GO:0070129) positive regulation of mitochondrial translation(GO:0070131)
0.0 0.4 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.2 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0 0.6 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.8 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.0 0.2 GO:0060832 oocyte animal/vegetal axis specification(GO:0060832)
0.0 0.6 GO:0008406 gonad development(GO:0008406)
0.0 0.7 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.4 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.0 0.1 GO:0097250 mitochondrial respiratory chain supercomplex assembly(GO:0097250)
0.0 0.2 GO:0000019 regulation of mitotic recombination(GO:0000019)
0.0 0.6 GO:0006298 mismatch repair(GO:0006298)
0.0 0.6 GO:0060841 venous blood vessel development(GO:0060841)
0.0 0.1 GO:0031061 negative regulation of histone methylation(GO:0031061)
0.0 0.1 GO:1901073 chitin biosynthetic process(GO:0006031) glucosamine-containing compound biosynthetic process(GO:1901073)
0.0 0.5 GO:0006446 regulation of translational initiation(GO:0006446)
0.0 0.6 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 0.2 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 0.3 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.2 GO:0071479 cellular response to ionizing radiation(GO:0071479)
0.0 0.6 GO:0015908 fatty acid transport(GO:0015908)
0.0 1.6 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.8 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.4 GO:0035622 intrahepatic bile duct development(GO:0035622)
0.0 0.3 GO:0051788 response to misfolded protein(GO:0051788) cellular response to misfolded protein(GO:0071218)
0.0 0.3 GO:0006513 protein monoubiquitination(GO:0006513)
0.0 0.6 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.0 0.1 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.0 0.1 GO:0051561 positive regulation of mitochondrial calcium ion concentration(GO:0051561)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0097524 sperm plasma membrane(GO:0097524)
0.2 0.6 GO:0017177 glucosidase II complex(GO:0017177)
0.2 0.9 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 0.8 GO:0070695 FHF complex(GO:0070695)
0.1 0.4 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.1 1.1 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.1 0.4 GO:0071065 alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065)
0.1 1.0 GO:0071546 pi-body(GO:0071546)
0.1 0.4 GO:0033186 CAF-1 complex(GO:0033186)
0.1 0.2 GO:0000941 condensed nuclear chromosome inner kinetochore(GO:0000941)
0.1 0.8 GO:0098894 presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) extrinsic component of presynaptic membrane(GO:0098888) extrinsic component of presynaptic endocytic zone(GO:0098894)
0.1 0.6 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 0.2 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.1 0.6 GO:0032300 mismatch repair complex(GO:0032300)
0.1 0.6 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.2 GO:0030896 checkpoint clamp complex(GO:0030896)
0.0 0.4 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.0 0.2 GO:0032019 mitochondrial cloud(GO:0032019)
0.0 2.1 GO:0005657 replication fork(GO:0005657)
0.0 0.2 GO:0035517 PR-DUB complex(GO:0035517)
0.0 0.9 GO:0045495 pole plasm(GO:0045495)
0.0 0.2 GO:0030891 VCB complex(GO:0030891)
0.0 0.6 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.2 GO:0031526 brush border membrane(GO:0031526)
0.0 0.4 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.0 0.3 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.3 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.2 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.3 GO:0031306 intrinsic component of mitochondrial outer membrane(GO:0031306)
0.0 0.2 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.1 GO:0031261 DNA replication preinitiation complex(GO:0031261)
0.0 0.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.1 GO:0030428 cell septum(GO:0030428)
0.0 0.3 GO:0034399 nuclear periphery(GO:0034399)
0.0 0.3 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.2 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 1.2 GO:0000786 nucleosome(GO:0000786)
0.0 0.2 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.2 GO:0031083 BLOC-1 complex(GO:0031083)
0.0 0.3 GO:0000407 pre-autophagosomal structure(GO:0000407)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.1 GO:0043139 5'-3' DNA helicase activity(GO:0043139)
0.2 0.6 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.2 0.5 GO:0055105 ubiquitin-protein transferase inhibitor activity(GO:0055105)
0.1 1.1 GO:0070137 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.1 0.7 GO:0008126 acetylesterase activity(GO:0008126)
0.1 0.3 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.1 0.4 GO:0000829 inositol heptakisphosphate kinase activity(GO:0000829) diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.1 0.5 GO:0070412 R-SMAD binding(GO:0070412)
0.1 0.6 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.1 0.6 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 0.5 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.1 0.3 GO:0005521 lamin binding(GO:0005521)
0.1 0.2 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.1 1.2 GO:0032190 acrosin binding(GO:0032190)
0.1 0.9 GO:0016783 sulfurtransferase activity(GO:0016783)
0.1 0.2 GO:0052726 inositol tetrakisphosphate 1-kinase activity(GO:0047325) inositol-1,3,4-trisphosphate 6-kinase activity(GO:0052725) inositol-1,3,4-trisphosphate 5-kinase activity(GO:0052726)
0.1 0.2 GO:0043739 G/U mismatch-specific uracil-DNA glycosylase activity(GO:0043739)
0.1 0.8 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 0.5 GO:0008494 translation activator activity(GO:0008494)
0.1 0.6 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 0.6 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.6 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.0 0.2 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.1 GO:0042806 fucose binding(GO:0042806)
0.0 0.4 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.0 0.6 GO:0030983 mismatched DNA binding(GO:0030983)
0.0 1.8 GO:0008408 3'-5' exonuclease activity(GO:0008408)
0.0 0.3 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.5 GO:0070566 adenylyltransferase activity(GO:0070566)
0.0 0.6 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.3 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.2 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.3 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 0.1 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.0 0.8 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.0 0.4 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.4 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.1 GO:0005483 soluble NSF attachment protein activity(GO:0005483)
0.0 0.4 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.0 0.2 GO:0005165 nerve growth factor receptor binding(GO:0005163) neurotrophin receptor binding(GO:0005165)
0.0 0.4 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 0.3 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.1 GO:0004362 glutathione-disulfide reductase activity(GO:0004362)
0.0 0.8 GO:0016409 palmitoyltransferase activity(GO:0016409)
0.0 0.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.1 GO:0004100 chitin synthase activity(GO:0004100)
0.0 0.3 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.4 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.9 GO:0003724 RNA helicase activity(GO:0003724)
0.0 1.0 GO:0043130 ubiquitin binding(GO:0043130)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.4 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 2.3 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.6 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.6 PID ATM PATHWAY ATM pathway
0.0 0.6 PID BARD1 PATHWAY BARD1 signaling events
0.0 0.2 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.6 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.6 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.0 0.4 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.7 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.4 PID RAC1 REG PATHWAY Regulation of RAC1 activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.1 0.6 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.1 0.4 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.7 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.6 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.6 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 0.7 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.5 REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS Genes involved in TGF-beta receptor signaling activates SMADs
0.0 0.6 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.6 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.4 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.2 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.3 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.4 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.0 0.2 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.5 REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle
0.0 0.4 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.3 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.2 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.2 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA