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PRJNA195909:zebrafish embryo and larva development
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Results for gmeb2
Z-value: 0.72
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Transcription factors associated with gmeb2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GMEB2 | dr11_v1_chr23_-_41824460_41824460 | 0.91 | 5.8e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_29910547 Show fit | 1.53 |
ENSDART00000151501
|
si:dkey-151m15.5 |
|
| chr17_-_51818659 Show fit | 1.22 |
ENSDART00000111389
ENSDART00000157244 |
exonuclease 3'-5' domain containing 2 |
|
| chr24_+_34069675 Show fit | 1.21 |
ENSDART00000143995
|
si:ch211-190p8.2 |
|
| chr1_-_49521407 Show fit | 1.20 |
ENSDART00000189845
ENSDART00000143474 |
zona pellucida glycoprotein 3c |
|
| chr15_-_20412286 Show fit | 1.13 |
ENSDART00000008589
|
calcineurin-like EF-hand protein 2 |
|
| chr17_-_36860988 Show fit | 1.06 |
ENSDART00000154981
|
SUMO1/sentrin specific peptidase 6b |
|
| chr2_-_17114852 Show fit | 1.05 |
ENSDART00000006549
|
PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae) |
|
| chr2_-_17115256 Show fit | 1.04 |
ENSDART00000190488
|
PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae) |
|
| chr13_+_40501455 Show fit | 0.99 |
ENSDART00000114985
|
heparanase 2 |
|
| chr18_-_20674121 Show fit | 0.96 |
ENSDART00000005145
|
ankyrin repeat, SAM and basic leucine zipper domain containing 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of gmeb2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.1 | GO:0000002 | mitochondrial genome maintenance(GO:0000002) |
| 0.0 | 1.6 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.1 | 1.2 | GO:0007339 | binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344) |
| 0.4 | 1.1 | GO:0045040 | outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040) |
| 0.3 | 1.1 | GO:0090230 | regulation of centromere complex assembly(GO:0090230) regulation of kinetochore assembly(GO:0090234) |
| 0.1 | 1.0 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
| 0.1 | 1.0 | GO:0034587 | piRNA metabolic process(GO:0034587) |
| 0.1 | 0.9 | GO:0050435 | beta-amyloid metabolic process(GO:0050435) |
| 0.1 | 0.8 | GO:0098927 | early endosome to late endosome transport(GO:0045022) vesicle-mediated transport between endosomal compartments(GO:0098927) |
| 0.0 | 0.8 | GO:0016185 | synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | GO:0005657 | replication fork(GO:0005657) |
| 0.0 | 1.2 | GO:0000786 | nucleosome(GO:0000786) |
| 0.1 | 1.1 | GO:0001401 | mitochondrial sorting and assembly machinery complex(GO:0001401) |
| 0.1 | 1.0 | GO:0071546 | pi-body(GO:0071546) |
| 0.2 | 0.9 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.0 | 0.9 | GO:0045495 | pole plasm(GO:0045495) |
| 0.1 | 0.8 | GO:0070695 | FHF complex(GO:0070695) |
| 0.1 | 0.8 | GO:0098894 | presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) extrinsic component of presynaptic membrane(GO:0098888) extrinsic component of presynaptic endocytic zone(GO:0098894) |
| 0.2 | 0.7 | GO:0097524 | sperm plasma membrane(GO:0097524) |
| 0.2 | 0.6 | GO:0017177 | glucosidase II complex(GO:0017177) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 2.1 | GO:0043139 | 5'-3' DNA helicase activity(GO:0043139) |
| 0.0 | 1.8 | GO:0008408 | 3'-5' exonuclease activity(GO:0008408) |
| 0.1 | 1.2 | GO:0032190 | acrosin binding(GO:0032190) |
| 0.1 | 1.1 | GO:0070137 | ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139) |
| 0.0 | 1.0 | GO:0043130 | ubiquitin binding(GO:0043130) |
| 0.1 | 0.9 | GO:0016783 | sulfurtransferase activity(GO:0016783) |
| 0.0 | 0.9 | GO:0003724 | RNA helicase activity(GO:0003724) |
| 0.1 | 0.8 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.0 | 0.8 | GO:0051959 | dynein light intermediate chain binding(GO:0051959) |
| 0.0 | 0.8 | GO:0016409 | palmitoyltransferase activity(GO:0016409) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.3 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 0.9 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 0.7 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 0.6 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 0.6 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 0.6 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.0 | 0.6 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.0 | 0.6 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.0 | 0.4 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.0 | 0.4 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.0 | 0.7 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.1 | 0.6 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.0 | 0.6 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.0 | 0.6 | REACTOME FANCONI ANEMIA PATHWAY | Genes involved in Fanconi Anemia pathway |
| 0.0 | 0.6 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.0 | 0.6 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.0 | 0.5 | REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS | Genes involved in TGF-beta receptor signaling activates SMADs |
| 0.0 | 0.5 | REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE | Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle |
| 0.1 | 0.4 | REACTOME INTEGRATION OF PROVIRUS | Genes involved in Integration of provirus |