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PRJNA195909:zebrafish embryo and larva development

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Results for grhl1

Z-value: 2.36

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Transcription factors associated with grhl1

Gene Symbol Gene ID Gene Info
grhl1
ENSDARG00000061391 grainyhead-like transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
grhl1dr11_v1_chr17_-_32413147_324131470.881.8e-03Click!

Activity profile of grhl1 motif

Sorted Z-values of grhl1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_22657566 8.02 ENSDART00000141048
ponzr5
plac8 onzin related protein 5
chr3_-_29977495 5.98 ENSDART00000077111
hsd17b14
hydroxysteroid (17-beta) dehydrogenase 14
chr22_+_22021936 5.56 ENSDART00000149586
gna15.1
guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 1
chr11_+_6116503 5.21 ENSDART00000176170
nr2f6b
nuclear receptor subfamily 2, group F, member 6b
chr13_+_18533005 5.00 ENSDART00000136024
ftr14l
finTRIM family, member 14-like
chr6_+_23057311 4.98 ENSDART00000026448
evpla
envoplakin a
chr8_-_24252933 4.93 ENSDART00000057624
zgc:110353
zgc:110353
chr16_+_7154753 4.32 ENSDART00000163281
ENSDART00000168274
bmper
BMP binding endothelial regulator
chr15_+_42560354 4.15 ENSDART00000059484
CLDN8 (1 of many)
zgc:110333
chr22_+_25672155 4.05 ENSDART00000087769
si:ch211-250e5.2
si:ch211-250e5.2
chr1_-_52498146 3.82 ENSDART00000122217
acy3.2
aspartoacylase (aminocyclase) 3, tandem duplicate 2
chr24_+_38671054 3.48 ENSDART00000154214
si:ch73-70c5.1
si:ch73-70c5.1
chr8_-_13541514 3.42 ENSDART00000063834
zgc:86586
zgc:86586
chr16_+_23431189 3.20 ENSDART00000004679
icn
ictacalcin
chr9_-_30264415 3.10 ENSDART00000060150
mid1ip1a
MID1 interacting protein 1a
chr16_-_31976269 2.98 ENSDART00000139664
styk1
serine/threonine/tyrosine kinase 1
chr4_-_12725513 2.77 ENSDART00000132286
mgst1.2
microsomal glutathione S-transferase 1.2
chr1_-_52497834 2.74 ENSDART00000136469
ENSDART00000004233
acy3.2
aspartoacylase (aminocyclase) 3, tandem duplicate 2
chr3_+_34140507 2.66 ENSDART00000131802
si:dkey-204f11.64
si:dkey-204f11.64
chr21_+_25625026 2.63 ENSDART00000134678
ovol1b
ovo-like zinc finger 1b
chr10_-_22127942 2.62 ENSDART00000133374
ponzr2
plac8 onzin related protein 2
chr12_+_30705769 2.50 ENSDART00000186448
ENSDART00000066259
kcnk1a
potassium channel, subfamily K, member 1a
chr5_-_57686487 2.48 ENSDART00000074264
crfb12
cytokine receptor family member B12
chr3_-_18755651 2.44 ENSDART00000145277
zgc:113333
zgc:113333
chr16_-_9675982 2.43 ENSDART00000113724
mal2
mal, T cell differentiation protein 2 (gene/pseudogene)
chr10_+_4924388 2.34 ENSDART00000108595
slc46a2
solute carrier family 46 member 2
chr3_-_16537441 2.33 ENSDART00000080749
ENSDART00000133824
eps8l1
eps8-like1
chr4_+_4232562 2.29 ENSDART00000177529
smkr1
small lysine rich protein 1
chr17_+_22102791 2.29 ENSDART00000047772
mal
mal, T cell differentiation protein
chr12_+_30706158 2.23 ENSDART00000133869
kcnk1a
potassium channel, subfamily K, member 1a
chr3_-_18756076 2.21 ENSDART00000055766
zgc:113333
zgc:113333
chr23_-_33986762 2.18 ENSDART00000144609
tmed4
transmembrane p24 trafficking protein 4
chr1_+_49352900 2.17 ENSDART00000008468
msx1b
muscle segment homeobox 1b
chr4_+_71401321 2.17 ENSDART00000158076
si:ch211-76m11.7
si:ch211-76m11.7
chr6_+_30668098 2.16 ENSDART00000112294
ttc22
tetratricopeptide repeat domain 22
chr2_+_35854242 2.11 ENSDART00000134918
dhx9
DEAH (Asp-Glu-Ala-His) box helicase 9
chr5_-_29570141 2.07 ENSDART00000043259
entpd2a.2
ectonucleoside triphosphate diphosphohydrolase 2a, tandem duplicate 2
chr19_-_41472228 2.06 ENSDART00000113388
dlx5a
distal-less homeobox 5a
chr2_-_58201173 2.03 ENSDART00000166282
pnp5b
purine nucleoside phosphorylase 5b
chr15_-_5901514 1.79 ENSDART00000155252
si:ch73-281n10.2
si:ch73-281n10.2
chr12_+_30360579 1.79 ENSDART00000152900
si:ch211-225b10.3
si:ch211-225b10.3
chr11_-_45140227 1.77 ENSDART00000184062
cant1b
calcium activated nucleotidase 1b
chr2_-_17827983 1.76 ENSDART00000166518
ptprfb
protein tyrosine phosphatase, receptor type, f, b
chr21_+_5801105 1.73 ENSDART00000151225
ENSDART00000184487
ccng2
cyclin G2
chr23_-_22650668 1.70 ENSDART00000132733
ca6
carbonic anhydrase VI
chr13_+_42544009 1.70 ENSDART00000145409
si:dkey-221j11.3
si:dkey-221j11.3
chr12_+_31673588 1.66 ENSDART00000152971
dnmbp
dynamin binding protein
chr15_+_22014029 1.64 ENSDART00000079504
ankk1
ankyrin repeat and kinase domain containing 1
chr23_-_22650992 1.59 ENSDART00000079007
ca6
carbonic anhydrase VI
chr8_-_13029297 1.56 ENSDART00000144305
dennd2da
DENN/MADD domain containing 2Da
chr7_-_56606752 1.52 ENSDART00000138714
sult5a1
sulfotransferase family 5A, member 1
chr8_+_8459192 1.41 ENSDART00000140942
ENSDART00000014939
comta
catechol-O-methyltransferase a
chr11_-_17964525 1.40 ENSDART00000018948
cishb
cytokine inducible SH2-containing protein b
chr2_+_5521671 1.39 ENSDART00000099647
ENSDART00000138443
crfb16
cytokine receptor family member B16
chr12_+_4036409 1.32 ENSDART00000106650
zgc:123217
zgc:123217
chr9_-_40014339 1.29 ENSDART00000166918
IKZF2
si:zfos-1425h8.1
chr3_+_37196258 1.26 ENSDART00000187944
ENSDART00000185896
fmnl1a
formin-like 1a
chr9_-_14108896 1.16 ENSDART00000135209
prkag3b
protein kinase, AMP-activated, gamma 3b non-catalytic subunit
chr5_-_37900350 1.14 ENSDART00000084839
ENSDART00000084841
ENSDART00000133437
tmprss13b
transmembrane protease, serine 13b
chr21_-_13668358 1.05 ENSDART00000180323
pnpla7a
patatin-like phospholipase domain containing 7a
chr15_+_5901970 1.02 ENSDART00000114134
wrb
tryptophan rich basic protein
chr24_-_8887825 0.99 ENSDART00000066781
elovl2
ELOVL fatty acid elongase 2
chr16_+_17715243 0.99 ENSDART00000149437
ENSDART00000149596
si:dkey-87o1.2
si:dkey-87o1.2
chr19_-_32500373 0.99 ENSDART00000052104
fuca1.1
alpha-L-fucosidase 1, tandem duplicate 1
chr8_+_3405612 0.96 ENSDART00000163437
zgc:112433
zgc:112433
chr14_-_32258759 0.93 ENSDART00000052949
fgf13a
fibroblast growth factor 13a
chr15_-_12360409 0.90 ENSDART00000164596
tmprss13a
transmembrane protease, serine 13a
chr5_-_28029558 0.74 ENSDART00000078649
abcb9
ATP-binding cassette, sub-family B (MDR/TAP), member 9
chr24_+_42074143 0.65 ENSDART00000170514
top1mt
DNA topoisomerase I mitochondrial
chr14_+_46216703 0.64 ENSDART00000136045
ENSDART00000142317
mgst2
microsomal glutathione S-transferase 2
chr15_+_29276508 0.63 ENSDART00000170537
ENSDART00000126559
rap1gap2a
RAP1 GTPase activating protein 2a
chr10_+_19525839 0.59 ENSDART00000162912
ENSDART00000158512
vsig8a
V-set and immunoglobulin domain containing 8a
chr14_+_4276394 0.47 ENSDART00000038301
gnpda2
glucosamine-6-phosphate deaminase 2
chr1_-_47161996 0.39 ENSDART00000053153
mhc1zba
major histocompatibility complex class I ZBA
chr20_-_29420713 0.33 ENSDART00000147464
ryr3
ryanodine receptor 3
chr22_-_13649588 0.32 ENSDART00000131877
si:ch211-279g13.1
si:ch211-279g13.1
chr21_+_11244068 0.26 ENSDART00000163432
arid6
AT-rich interaction domain 6
chr16_-_20294236 0.25 ENSDART00000059623
plekha8
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8
chr15_+_41919484 0.23 ENSDART00000099821
ENSDART00000146246
nlrp16
NACHT, LRR and PYD domains-containing protein 16
chr4_-_26413391 0.21 ENSDART00000145955
b4galnt3a
beta-1,4-N-acetyl-galactosaminyl transferase 3a
chr4_+_76722754 0.17 ENSDART00000153867
ms4a17a.3
membrane-spanning 4-domains, subfamily A, member 17A.3
chr7_-_24193051 0.15 ENSDART00000169737
ENSDART00000171085
si:ch211-216p19.6
si:ch211-216p19.6
chr16_-_10837245 0.13 ENSDART00000036891
rabac1
Rab acceptor 1 (prenylated)
chr13_-_37210369 0.13 ENSDART00000140744
si:dkeyp-77c8.4
si:dkeyp-77c8.4
chr5_-_6567464 0.10 ENSDART00000184985
tnks1bp1
tankyrase 1 binding protein 1
chr15_+_41901970 0.09 ENSDART00000152724
si:ch211-191a16.5
si:ch211-191a16.5
chr3_+_32832042 0.09 ENSDART00000132679
ENSDART00000035759
cd2bp2
CD2 (cytoplasmic tail) binding protein 2
chr7_+_19835569 0.02 ENSDART00000149812
ovol1a
ovo-like zinc finger 1a

Network of associatons between targets according to the STRING database.

First level regulatory network of grhl1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.4 GO:0045056 transcytosis(GO:0045056)
0.3 2.1 GO:0033986 response to methanol(GO:0033986) cellular response to methanol(GO:0071405)
0.3 5.6 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.3 2.1 GO:0021628 olfactory nerve development(GO:0021553) olfactory nerve morphogenesis(GO:0021627) olfactory nerve formation(GO:0021628)
0.2 1.4 GO:0042424 catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
0.2 1.8 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.2 6.5 GO:0043049 otic placode formation(GO:0043049)
0.2 4.7 GO:0030322 stabilization of membrane potential(GO:0030322)
0.2 1.0 GO:0006004 fucose metabolic process(GO:0006004)
0.2 0.5 GO:0006043 glucosamine metabolic process(GO:0006041) glucosamine catabolic process(GO:0006043)
0.1 0.6 GO:0006691 leukotriene metabolic process(GO:0006691) leukotriene biosynthetic process(GO:0019370)
0.1 5.0 GO:0045103 intermediate filament-based process(GO:0045103) intermediate filament cytoskeleton organization(GO:0045104)
0.1 0.7 GO:0019885 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.1 0.9 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.1 3.3 GO:0036269 swimming behavior(GO:0036269)
0.1 3.1 GO:0046890 regulation of lipid biosynthetic process(GO:0046890)
0.1 1.5 GO:0051923 sulfation(GO:0051923)
0.0 1.0 GO:0034625 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 1.8 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.7 GO:0006265 DNA topological change(GO:0006265)
0.0 0.2 GO:0035627 intracellular lipid transport(GO:0032365) ceramide transport(GO:0035627)
0.0 1.7 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 1.2 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 2.5 GO:0007596 blood coagulation(GO:0007596)
0.0 2.7 GO:0009913 epidermal cell differentiation(GO:0009913)
0.0 2.2 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 1.3 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 1.4 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 2.1 GO:0050684 regulation of mRNA processing(GO:0050684)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.7 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.1 0.7 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.1 5.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 4.7 GO:0043204 perikaryon(GO:0043204)
0.1 1.2 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 1.8 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.1 2.2 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1 6.6 GO:0016324 apical plasma membrane(GO:0016324)
0.0 0.3 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 5.0 GO:0005882 intermediate filament(GO:0005882)
0.0 1.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 2.4 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 1.4 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 1.9 GO:0005795 Golgi stack(GO:0005795)
0.0 0.9 GO:0030426 growth cone(GO:0030426)
0.0 4.3 GO:0031012 extracellular matrix(GO:0031012)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 5.0 GO:0019215 intermediate filament binding(GO:0019215)
0.7 5.6 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.6 6.6 GO:0004046 aminoacylase activity(GO:0004046)
0.5 4.7 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.5 1.4 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.3 1.0 GO:0015928 alpha-L-fucosidase activity(GO:0004560) fucosidase activity(GO:0015928)
0.3 4.7 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.2 0.7 GO:0046978 TAP1 binding(GO:0046978)
0.2 2.0 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.2 0.7 GO:0033149 FFAT motif binding(GO:0033149)
0.2 2.4 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.2 0.6 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.2 0.5 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
0.1 3.8 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
0.1 2.7 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 3.3 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 3.2 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 4.3 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 2.8 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 2.1 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.1 1.8 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 0.3 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763)
0.0 0.2 GO:0035620 ceramide transporter activity(GO:0035620) ceramide 1-phosphate binding(GO:1902387) ceramide 1-phosphate transporter activity(GO:1902388)
0.0 1.0 GO:0102337 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.2 GO:0033842 N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity(GO:0033842)
0.0 1.4 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 1.2 GO:0016208 AMP binding(GO:0016208)
0.0 5.2 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879)
0.0 0.9 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 3.9 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 1.7 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 1.5 GO:0008146 sulfotransferase activity(GO:0008146)
0.0 1.1 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 1.8 GO:0008201 heparin binding(GO:0008201)
0.0 2.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.7 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 4.3 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.3 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 1.0 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.6 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 2.2 REACTOME MRNA SPLICING Genes involved in mRNA Splicing